IRE2_Hsap -------------FNP--KDVLGRGAGGTFVFRGQFEGR-AVAVKRLLRECFGLVRREVQ
IRE1_Hsap -------------FCP--KDVLGHGAEGTIVYRGMFDNR-DVAVKRILPECFSFADREVQ
ire-1_Dmel -------------FST--NEVLGKGCEGTFVFKGTFEER-FVAVKRLLPECFTFADREVA
IRE2_Mmus -------------FNP--KDVLGRGAGGTFVFRGQFEGR-AVAVKRLLRECFGLVRREVQ
IRE1_Mmus -------------FCP--KDVLGHGAEGTIVYKGMFDNR-DVAVKRILPECFSFADREVQ
ire-1_Cele -------------YSP--SDILGTGCEGTVVYRGTFDGR-EVAVKRVVSEFVKFAHREAD
IRE1_Scer -------------VVS--EKILGYGSSGTVVFQGSFQGR-PVAVKRMLIDFCDIALMEIK
IreA_Ddis -------------IIT--NKILGTGSCGTIVYEGKMEGR-KVAVKRMLSQFVKFADREVS
IrlA_Ddis ------------------NNIIGRGSNGTLVFRGIWNDRIPVAVKQMQKAFNPHISKEIE
IrlB_Ddis -------------FNRNESNILGRGSNGTLVFKGLWSDKIPVAIKQMQKAFNPLINKEVE
IrlB_C2d_Ddis -------------FNRNESNILGRGSNGTLVFKGLWSDKIPVAIKQMQKAFNPLINKEVE
IrlC_Ddis -------------FNRKEENVLGRGSNGTLVFKGIWNNRIPVAIKQMQKMFNPLISKEIE
IrlD_Ddis -------------FSRKDEFIIGRGSNGTLVFKGIWNDRIPVAIKQMHKAFNPLISKEIE
IrlE_Ddis -------------KKE--SNILGRGSNGTLVFKGIWNNRIPVAIKQMQKMFNPLISKEIE
IrlF_Ddis ---------------E--SNILGRGSNGTLVFKGIWSDKIPVAIKQMQKAFNPLINKEVE
IrlF_C2d_Ddis ---------------E--SNILGRGSNGTLVFKGIWSDKIPVAIKQMQKAFNPLINKEVE
10577_Tthe ----------------------------------VNIGR-EIAVKQLLKDNKDLASKEIQ
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin -------------VVS--DTILGFGSHGTVVFQGSLQGR-AVAVKRLLKDFVTLASREVS
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque -------------YDK--NSLLGKGASST-VYKGTFKRE-GVAVKRMKEE-LSD--DDKK
AqueK162_Aque -------------YDK--KSLLGTGASST-VYKGTFKEE-DVAVKRMKEE-LSD--EYKE
AqueK163_Aque -------------YDK--KSLLGKGASST-VHKGTFKEE-AVAVKRMKEE-LSD--EYKD
AqueK164_Aque ------------------------------VYKGQFKGQ-DIAVKKVGKKDVIEDITEIK
AqueK165_Aque -------------FDK--KLLLGKGASST-VHKGTFKEE-DVAVKRMKEE-LSD--EYKE
AqueK166_Aque -------------VCE--DSLLGKGKSST-VRRGTYNGQ-EVAVKRLYEKTLSS--EDIN
AqueK167_Aque -------------YDV--SIKLGQGASSI-VHKGTYEGQ-EVAVKKMKDK-LTD--DAKL
AqueK168_Aque GGGAIEATDGERGSNR--SSIALSDSTQSIYRNGSFDSR-PVAVKRVIQNYFDLADREVA
AqueK169_Aque -------------YFR--NEKLGDGASGTTVYKGQFSGK-DVAVKVGKKTAIRD--LEKK
IRE-2_Smoe --------------------VIGYGSHGTRILEGKLDQR-QVAVKSILSGFYHKASKEIA
IRE-1_Smoe --------------------VIGYGSHGTRILEGKLDQR-QVAVKSILSGFYHKASKEIA
IRE2_Hsap LLQE--SDRHPNVLRYFCTERG--PQFHYIALELCRASLQEYVENPDLD-----------
IRE1_Hsap LLRE--SDEHPNVIRYFCTEKD--RQFQYIAIELCAATLQEYVEQKDFA-----------
ire-1_Dmel LLRE--SDAHENVVRYFCTEQD--RQFRYIAVELCAATLQDYTEGDRSL-----------
IRE2_Mmus LLQE--SDRHPNVLRYFCTEHG--PQFHYIALELCQASLQEYVESPDLD-----------
IRE1_Mmus LLRE--SDEHPNVIRYFCTEKD--RQFQYIAIELCAATLQEYVEQKDFA-----------
ire-1_Cele LLRE--SDTHPHVIRYFCMESD--SQFRYLALELCIASLNDYVEQKEVQ-----------
IRE1_Scer LLTE--SDDHPNVIRYYCSETT--DRFLYIALELCNLNLQDLVESKNVS-----------
IreA_Ddis ILIH--SDEHTNVVRYYAKEED--DEFIYLAISFCQKSLDMYVQQTLSLQISPTDSPSIQ
IrlA_Ddis VLIRLTSNNCSNMIRYIDQEED--QLFVYLGLTLCEESLQDLMESKRYK-----------
IrlB_Ddis ALISLTSKNCSNMIRYIDKEED--KLHVYLGLTLCDGSLQNLVESGKLN-----------
IrlB_C2d_Ddis ALISLTSKNCSNMIRYIDKEED--KLHVYLGLTLCDGSLQNLVESGKLN-----------
IrlC_Ddis VLITLTNKNCYNIVRYIDQEED--ESCVYLGLTLCDGSLQNLVEKGDNNL----------
IrlD_Ddis VLITLTNKNCNNIVRYIDQEED--DMFVYLGLTLCNGSLQNLVEKDLEINLIST------
IrlE_Ddis ILIGLTNK-NLNLVGYIDQEED--ENCVYLGLTLCDGSLQSLYDQSKLN-----------
IrlF_Ddis ALITLTNKNCSNMIRYIDKEED--KHFVYLGLTLCDVSLQYLVENGKLN-----------
IrlF_C2d_Ddis ALITLTNKNCSNMIRYIDKEED--KHFVYLGLTLCDVSLQYLVENGKLN-----------
10577_Tthe MLIK---LQHKNIIKYYYFEET--KDHILLGLEKCVGSISDLIDYANRK-----------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ILQE--SDDHPNVIRYYYQEAH--ANFLYIALELCPASLADIIETPDRE-----------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque -------------------------EYYYLAFQLCLTSLENFIKNEEKR-----------
AqueK161_Aque FLLS---IKHDNIVLVHCIY----------------------FKKLKKV-----------
AqueK162_Aque LLLN---IKHENIVLVLCIY----------------------FKEFKEV-----------
AqueK163_Aque LLKN---IKHENIVLVLCIY----------------------FKEFEKV-----------
AqueK164_Aque LLMK---CRNQNIVEYYHFESD--IEYHYLAFQLCLTSLEKFIIDKKQR-----------
AqueK165_Aque LLLN---IKHKNIVLVLCIESY--QGLDHIVLELCLASFHQYFKEFEKV-----------
AqueK166_Aque LLLT---IQHENIVKILAIEDG--LENQYIVLELCLASLDLFCVNYKKV-----------
AqueK167_Aque LLLD---IKHENIVQLLNIETDEHNEHDYIILELCLASLSKYFKHYETV-----------
AqueK168_Aque LLRE--SDQHPNVIRYFCMEED--PTFRYLALELCSATLHEYVEGQKMS-----------
AqueK169_Aque ILER---CRHENIVEYYHFDSD--IEYNYLAFQLCDISLENFIENEDKR-----------
IRE-2_Smoe ALIEL--DTHPNVVRYYSMEQD--NDFVYIALERCSFNLETFILVHAAGA----------
IRE-1_Smoe ALIEL--DTHPNVVRYYSMEQD--NDFVYIALERCSFNLETFIVVHAAGA----------
IRE2_Hsap ----------------------RG------------------------------------
IRE1_Hsap ----------------------HL------------------------------------
ire-1_Dmel ----------------------EL------------------------------------
IRE2_Mmus ----------------------RW------------------------------------
IRE1_Mmus ----------------------HL------------------------------------
ire-1_Cele ----------------------QN------------------------------------
IRE1_Scer ----------------------DENLK-------------L-------------------
IreA_Ddis SSNNNGNGNNGN-----NNNNNQ-II----------------------------------
IrlA_Ddis ----------------------EFIEK-------------TTTT-NITTTFNNNIIDEN-
IrlB_Ddis ----------------------DFVIS-------------S-------------------
IrlB_C2d_Ddis ----------------------DFVIS-------------S-------------------
IrlC_Ddis -------------------TLTQFLGY-------------DINS-------------SS-
IrlD_Ddis -S-NN--EN-NN-----NNKLKNFIG----------------------------------
IrlE_Ddis ----------------------EFINQ-------------NNNQ-N-----------NN-
IrlF_Ddis ----------------------EFINS-------------S-------------------
IrlF_C2d_Ddis ----------------------EFINS-------------S-------------------
10577_Tthe ----------------------NKKKSEQDLKALYNIKTDF-------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ----------------------AF-RD-------------I-------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ----------------------EAILR---------------------------------
AqueK161_Aque ----------------------MDKFD---------------------------------
AqueK162_Aque ----------------------MNKFN---------------------------------
AqueK163_Aque ----------------------TNKFD---------------------------------
AqueK164_Aque ----------------------EVILQ---------------------------------
AqueK165_Aque ----------------------MNKFN---------------------------------
AqueK166_Aque ----------------------ANRFS---------------------------------
AqueK167_Aque ----------------------SSQFV---------------------------------
AqueK168_Aque ----------------------EF------------------------------------
AqueK169_Aque ----------------------KDLIR---------------------------------
IRE-2_Smoe -------DNRTEVNEFEEKELQEILQQ-------------KLTLWD-----------RSC
IRE-1_Smoe -------DNRTEVNEFEEKELQEILQQ-------------KLTLWD-----------RSC
IRE2_Hsap --GLEPEVVLQQLMSGLAHLHS-LHIVHRDLKPGNILITGPDSQ----------------
IRE1_Hsap --GLEPITLLQQTTSGLAHLHS-LNIVHRDLKPHNILISMPNAH----------------
ire-1_Dmel QNHIDVWQVLSQAASGLSHLHS-LDIVHRDIKPQNVLISLPDAK----------------
IRE2_Mmus --GLEPTTVLQQMMSGLAHLHS-LHIVHRDLKPANILMAGPDSQ----------------
IRE1_Mmus --GLEPITLLHQTTSGLAHLHS-LNIVHRDLKPHNILLSMPNAH----------------
ire-1_Cele -VTIALRDIMKQATDGLAHLHA-SKIVHRDMKPQNVLITMASQR----------------
IRE1_Scer QKEYNPISLLRQIASGVAHLHS-LKIIHRDLKPQNILVSTSSRFTAD-------------
IreA_Ddis -IDNKTKQMILELFKGLEHLHS-LNIVHRDIKPHNVLIDP--------------------
IrlA_Ddis LYEQRILSLFKDVINGINFLHC-QDIVHNDLNPRNILVHK--------------------
IrlB_Ddis --NKSIIELAKDILFGIQFLHS-HDIVHNDLNPRNILTLIGKTSNN--------------
IrlB_C2d_Ddis --NKSIIELAKDILFGIQFLHS-HDIVHNDLNPRNILTLIGKTSNN--------------
IrlC_Ddis KNNSRLLELIKDIVYGIQFLHQ-QGIVHNDLNPRNILIKD--------------------
IrlD_Ddis -SELRLLELIKDIVYGIQFLHQ-QGIVHNDLNPRNILIKD--------------------
IrlE_Ddis NNNNRVLDLIIGMINGVIFLHD-QNIVHNDLNPRNILVKD--------------------
IrlF_Ddis --GKSLNELAKDIINGVQFLHS-HDIVHNDLNPRNILTLSTNKNNNNNNKSNNKIKSNNN
IrlF_C2d_Ddis --GKSLNELAKDIINGVQFLHS-HDIVHNDLNPRNILTLSTNKNNNNNNKSNNKIKSNNN
10577_Tthe FIKSTMKNTFKDCLEGLSYLHS-QGVIHRDIKPENILIHYNK------------------
IRE1_Spur --------------------------VHRDIKPHNVLISQPNQH----------------
CC1G_06931_Ccin AISFDPKRALKQITSGLKHLHA-LKLVHRDIKPQNILITTNKSTG---------------
AqueK159_Aque --------------------------IHRDIKPGNILLVQKSS-----------------
AqueK160_Aque DFVVSKKEILHGAIRGLNHLHNEHNIVHRDVKPSNILIVQRNSG----------------
AqueK161_Aque GLTVVKKNVNQDAVKGLEYLHE-QNIVHRDIKPGNILLVQKSS-----------------
AqueK162_Aque GLTVVKKDVNQDAVRGLEYLHE-QNIVHRDIKPGNILLVQKSP-----------------
AqueK163_Aque GLTVVKKDVNQDAVRGLEYLHE-QSIVHRDIKPGNILLVQKSS-----------------
AqueK164_Aque GFIVNKRDIISDAIRGLNHLHE-KHIVHRDIKPSNILLVQRHSF----------------
AqueK165_Aque GLTVVKKDVNQDAVRGLEYLHE-QNIVHRDIKPGNILLVQKSS-----------------
AqueK166_Aque GFIVVKENIIRDAVKGLEYLHK-RWIVHRDIKPGNILLLQKGS-----------------
AqueK167_Aque GLNVVIREILQDAVKGMEYLHK-RNVVHRDLKPGNILLVQKSSS----------------
AqueK168_Aque --SIDEKHIIAESMSGINHLHS-LGIVHRDLKPQNVLLRTS-SS----------------
AqueK169_Aque DFYVNKKEILFDSIKGLSYLHK-ENIVHRDVKPSNILLVRRNSS----------------
IRE-2_Smoe LPSPLLMRLMRDVLEGLVHLHK-LGYVHRDLKPQNVLILRSG------------------
IRE-1_Smoe LPSPLLMRLMRDVLEGLVHLHK-LGYVHRDLKPQNVLILRSG------------------
:*.*::* *:*
IRE2_Hsap --------GLGRVVLSDFGLCKKLPAGRCSFSL--HSG-IPGTEGWMAPELLQLL-----
IRE1_Hsap --------GKIKAMISDFGLCKKLAVGRHSFSR--RSG-VPGTEGWIAPEMLSED-----
ire-1_Dmel --------GKVRVMISDFGLCKKLNFGKTSFSR--RSG-VTGTDGWIAPEMMRS------
IRE2_Mmus --------GQGRVVISDFGLCKKLPVGRCSFSL--HSG-IPGTEGWMAPELLQL------
IRE1_Mmus --------GRIKAMISDFGLCKKLAVGRHSFSR--RSG-VPGTEGWIAPEMLSED-----
ire-1_Cele --------GEMRAVISDFGLCKRVQPGKNSISRGIASG-LAGTDGWIAPEVLIS------
IRE1_Scer ---QQTGAENLRILISDFGLCKKLDSGQSSFRTNLNN--PSGTSGWRAPELLEESNNLQC
IreA_Ddis ---------NNRVKISDMGLGKLLDNDDQSLTF--TS----DSHGWQPAEYLNGT-----
IrlA_Ddis ----------GNFVISDLGLSKMQVETSYSFTN--N-A-PTGQEGYHPIEVLQE------
IrlB_Ddis -----NNSSNNSFIISDLGLSKMEVESSYSFTS--N-I-PTGQGGYHPFEVLQS------
IrlB_C2d_Ddis -----NNSSNNSFIISDLGLSKMEVESSYSFTS--N-I-PTGQGGYHPFEVLQS------
IrlC_Ddis ----------DRFIISDLGLSKMEVTSSYSFTM--H-A-PTGQEGFHPAEVLLE------
IrlD_Ddis ----------DRFIISDLGLSKMEVTSSYSFTM--H-A-PTGQEGFHPAEVLLE------
IrlE_Ddis ----------NRLIISDLGLSKMNVSSTYNFST--NAI-PTGQDGYHPVEVLLE------
IrlF_Ddis SNNNSNNNSNNSFIISDLGLSKMEVESSYSFTT--N-V-PTGQGGYHPVEVLQS------
IrlF_C2d_Ddis SNNNSNNNSNNSFIISDLGLSKMEVESSYSFTT--N-V-PTGQGGYHPVEVLQS------
10577_Tthe -----------EIKLADFGLSKNISKTNVIFT--N----DIGTWGWRPLEQIDN------
IRE1_Spur --------GKVKAMISDFGLCKKLSAGRMSFSR--RSG-VAGTDGWIAPEMLTGQ-----
CC1G_06931_Ccin -----RGRPTYRMLISDFGLCKKLDVDQTSFLPTMNGGMGAGTVGWRAPEILRGEVKLDD
AqueK159_Aque -------SSEVKAVLADFGISTELNE-REAVTR--Q-R-GRRTDTWMAPELLLDDL----
AqueK160_Aque -------SMQIKAVISDFGIATELEPDRYSQTT--I-G-LKGTLMWLAPELVNKTV----
AqueK161_Aque -------SSEVKAVLADFGISTKLNN-RDAVTT--Q-R-RRGTDTWMGPELLLDDI----
AqueK162_Aque -------LSEVKAVLADFDLSAKLDDDRSSKTT--L-N-KRGTLSWMAPELLVEDG----
AqueK163_Aque -------SSEVKAVLADFGLSTKLDDDQFSKTT--V-D-GRGTKAYIPPELLVEDG----
AqueK164_Aque -------TKEIKAVIADFGTATEIDFDEYLKTI--S-R-VRGTLVWLAPELLGDKK----
AqueK165_Aque -------SSEVKAVLADFDLSTKLDDDRSLKTT--L-N-KRGTLSWMAPELLVKDG----
AqueK166_Aque -------SSEVKAVLADFGISTKLTS-RDSKTT--H-R-GRVTDTWMAPELLLDDP----
AqueK167_Aque -------SADVKAVLADFGISVTLIDDLNSLTT--R-T-ARGTDTWKAPELLLDNR----
AqueK168_Aque --------LKVRALISDFGLCRKLPDGRGSFTA--QSG-ILGTEGWIAPEMFQDR-----
AqueK169_Aque -------SMKIKAVISDFGIAAELDPGRISKTT--T-G-LKGTLLWVAPELLNKRR----
IRE-2_Smoe --------TFLSAKISDMGISKRLNDGASGIDK--LTT-GMGSSGWQAPEQIQG------
IRE-1_Smoe --------TFLSAKISDMGISKRLNDGASGIDK--LTT-GMGSSGWQAPEQIQG------
::*:. : * .
IRE2_Hsap ------------------------------------------------P-PDSPTSAVDI
IRE1_Hsap ------------------------------------------------C-KENPTYTVDI
ire-1_Dmel ---------------------------------------------------QRTTTAVDI
IRE2_Mmus ------------------------------------------------P-PDSPTSAVDI
IRE1_Mmus ------------------------------------------------C-KDNPTYTVDI
ire-1_Cele ---------------------------------------------------ASTSYPVDI
IRE1_Scer QVETEHSSSRHTVVSSDSFY-------------------------DPFT-KRRLTRSIDI
IreA_Ddis ---------------------------------------------------NRNTKKVDI
IrlA_Ddis ---------------------------------------------------KRKTKSVDI
IrlB_Ddis ---------------------------------------------------KRMTKSVDI
IrlB_C2d_Ddis ---------------------------------------------------KRMTKSVDI
IrlC_Ddis ---------------------------------------------------KRKTKSVDI
IrlD_Ddis ---------------------------------------------------KRKTKSVDI
IrlE_Ddis ---------------------------------------------------KRKTKSVDV
IrlF_Ddis ---------------------------------------------------KRMTKSVDI
IrlF_C2d_Ddis ---------------------------------------------------KRMTKSVDI
10577_Tthe ---------------------------------------------------QPLTYNTDV
IRE1_Spur ---------------------------------------------------DRTTTAIDI
CC1G_06931_Ccin -LS----------------DDHSMSSRGSVSTINGSSSSSSTSGLSTAK-PTRLTKSVDI
AqueK159_Aque ------------------------------------------------T-DCKFSRESDI
AqueK160_Aque ---------------------------------------------------KKFSKAVDI
AqueK161_Aque ------------------------------------------------K-ACKFSRESDI
AqueK162_Aque ------------------------------------------------L-ELQFSLQSDI
AqueK163_Aque ------------------------------------------------S-KLKFSPQSDI
AqueK164_Aque ---------------------------------------------------PKFSKAIDI
AqueK165_Aque ------------------------------------------------L-ELQFSLQSDI
AqueK166_Aque ------------------------------------------------S-GCKFSRQSDI
AqueK167_Aque ------------------------------------------------K-QRKCGRESDI
AqueK168_Aque ---------------------------------------------------TRVTCAVDI
AqueK169_Aque ------------------------------------------------DPRLKYSKAVDV
IRE-2_Smoe ---------------------------------------------------ERQTRAVDM
IRE-1_Smoe ---------------------------------------------------ERQTRAVDM
*:
IRE2_Hsap FSAGCVFYYVLSGGSHPFGD-SLYRQA----NIL---TGAPCLAHLEEEV----HDKVVA
IRE1_Hsap FSAGCVFYYVISEGSHPFGK-SLQRQA----NIL---LGACSLDCLHPEK----HEDVIA
ire-1_Dmel FSLGCVYYYVLSGGHHAFGD-NLKRQA----NIL---SHEYNLAKLRPEDDSEDSRIILA
IRE2_Mmus FSAGCVFYYVLSGGSHPFGE-SLYRQA----NIL---SGDPCLAQLQEET----HDKVVA
IRE1_Mmus FSAGCVFYYVISEGNHPFGK-SLQRQA----NIL---LGACNLDCFHSDK----HEDVIA
ire-1_Cele FSLGCIFYYVLTSGTHPFGK-SLHRQA----NIV---NGEYTLNKLAD-L----DDWSLA
IRE1_Scer FSMGCVFYYILSKGKHPFGD-KYSRES----NII---RGIFSLDEMKCLHD--RSLIAEA
IreA_Ddis FSLGCVVYYLLT-GAHPFGH-RYNREK----NVL---KGKFDIDQIK--------HLPDI
IrlA_Ddis FSLGCILFYLLTNGQHPFGNNKLLRVA----NIV---YDKPDLEPLK--------FNAPA
IrlB_Ddis FSLGCILFYLLTNGQHPFGNDKLFRIV----NII---SNKMNLTPLN--------SNQLA
IrlB_C2d_Ddis FSLGCILFYLLTNGQHPFGNDKLFRIV----NII---SNKMNLTPLN--------SNQLA
IrlC_Ddis FSMGCILFYLMTGGQHPFGD-KFYRIV----NIL---TDKPILEPLK--------HNLVA
IrlD_Ddis FSMGCILFYLMTGGQHPFGD-KFFRMA----NIL---TDKPILEPLK--------HNLVA
IrlE_Ddis FSLGCLIYFIMTNGAHPFGD-KFSRLR----YIT---KSKYNLSQLS-------NLNLVA
IrlF_Ddis FSLGCILFYLFTNGQHPFGNDKLFRIY----NIM---LNKVNLELLG--------HNLLA
IrlF_C2d_Ddis FSLGCILFYLFTNGQHPFGNDKLFRIY----NIM---LNKVNLELLG--------HNLLA
10577_Tthe FSLGCVFYYIYTQGGHPFGE-YLRM-------------------------E-----DETL
IRE1_Spur FSLGCVFYYVLSNGKHPFGD-SLHRQA----NII---SGEYSLDLLP-------PDDEIA
CC1G_06931_Ccin FALGCLYYYTLTNGSHPYGD-RFEREV----NIL---KDAKSLDLLERFGE--E--GTEA
AqueK159_Aque FSMGCIIYYVLTKGRHPFNK-GHDNDYTVHQNIKNYM--ICDFQ----LL----NDKPVA
AqueK160_Aque FSMGCVMYYVLSDGHHPFGN-DIV---AIIQNFG---THSYTLDDISDEV----KDRETA
AqueK161_Aque FSMGCVIYFVETGGSHPFDK-GHDDDYTIHQNVKNYD--RCDFR----LL----HGKPKA
AqueK162_Aque FSMGCVIYFAETDGNHPFDT-GDSRGAAIHLNVKNYN--PCDFH----LL----NGKPKA
AqueK163_Aque FSMGCVIYFAETDGHHPFDT-GDSRGAAIHQNVKDYN--PCDFR----LL----DGKPIA
AqueK164_Aque FSMGCVIYYVLSDGHHPLGD-ESL---DIGIALKSYSTHSFTLDGISDEV----EDKEPA
AqueK165_Aque FSMGCVIYFAETDGNHPFDT-GDSRGAAIHQNVKNYN--PCDFH----PL----NGKPKA
AqueK166_Aque FSMGCVTYYLITKGHHPFNR-GHDNVFRIHQNVKNYV--TCDFQ----LL----NDKPLA
AqueK167_Aque FAMGCVIYFAETGGNHPFDT-GDN--ADIDQNVKMYK--KCDFS----LL----DDKPKA
AqueK168_Aque FAMGCVIYYVLSCGGHPFGP-PLKRQA----NIE---AGDFSLKALIG------EDRYTA
AqueK169_Aque FSMGCVMYYVLSDGRHPFGE-DII---TIVQNFG---THSYRLDGISGKV----EDREPA
IRE-2_Smoe FSVGCLLYFCITGGQHPFGG-RLERDM----NIV---SGKMDLFAVD--------HYPEA
IRE-1_Smoe FSVGCLLYFCVTGGQHPFGG-RLERDM----NIV---SGKMDLFAVD--------HYPEA
*: **: :: : * *. .
IRE2_Hsap RDLVGAMLSPLPQP----------------------RPSAPQVLAHPFF
IRE1_Hsap RELIEKMIAMDPQK----------------------RPSAKHVLKHPFF
ire-1_Dmel EQLISDMIHKDPQS----------------------RPPARCIGNHPLF
IRE2_Mmus LDLVRAMLSLLPQD----------------------RPSAGWVLAHPLF
IRE1_Mmus RELIEKMIAMDPQQ----------------------RPSAKHVLKHPFF
ire-1_Cele DDLISSMLNVEPLH----------------------RLTADAVLNHPFF
IRE1_Scer TDLISQMIDHDPLK----------------------RPTAMKVLRHPLF
IreA_Ddis HQLVHSMIQFEPEK----------------------RPDIGECINHPFF
IrlA_Ddis LDLVRLMISQDEKK----------------------RPTIDTILNHPLF
IrlB_Ddis CTLIKSMISKDESI----------------------RPTIQNVLNHPLF
IrlB_C2d_Ddis CTLIKSMISKDESI----------------------RPTIQNVLNHPLF
IrlC_Ddis CDLISQMISKNESD----------------------RPTIEKILLHPFF
IrlD_Ddis CDLISQMISKNESD----------------------RPTTENILLHPFF
IrlE_Ddis THLIELMISYDESK----------------------RPTLSSVLKHPLF
IrlF_Ddis CDLIKSMISNDESK----------------------RPTIENVLNHPLF
IrlF_C2d_Ddis CDLIKSMISNDESK----------------------RPTIENVLNHPLF
10577_Tthe KDLIQKMIHNDQSK----------------------RLTVKECLKHPYF
IRE1_Spur HQLITQMVDPYFDT----------------------RPEANAILRHPFF
CC1G_06931_Ccin CDLIEKMLDPEASE----------------------RPDTTACLLHPFF
AqueK159_Aque RALIKNMMKHNKDS----------------------RPSASEVLDDPYF
AqueK160_Aque KHLIKQMIHKDKDL----------------------RISVEEVLNHCYF
AqueK161_Aque TALIKKTIQLDRAS----------------------RPSASEVLDDPYF
AqueK162_Aque TALILKMIKRDRAS----------------------RPSASEVLDDPYF
AqueK163_Aque SALINKMIQHNRAS----------------------RPSASEVLQDPYF
AqueK164_Aque KDLIMQMMHENKDL----------------------RIPIGKVLDHCYF
AqueK165_Aque TALIFKMITRDRAS----------------------RPSASEVLDDRYF
AqueK166_Aque RALIKNMIKYNKDS----------------------RPCASEVLGDPYF
AqueK167_Aque KDLIEKMIQLDKYS----------------------RPTASVVLQDPYF
AqueK168_Aque EHLVNNMISFNSKL----------------------RPTADEVLHHCLF
AqueK169_Aque KDLIVQMIHENKDLSVVSDIYKTQTGTKFILNTDHKAGDQQETLQHIYT
IRE-2_Smoe IDIISSLLAMDPKD----------------------RPTSMQVKLHPFF
IRE-1_Smoe IDIISSLLAMDPKD----------------------RPTAMQVKLHPFF
:: : .