IRE2_Hsap MASAVRGSR-------------------------------------PWPR--L-GLQL--
IRE1_Hsap MPARRLLLL----------------------------------------------LTL--
ire-1_Dmel MRFCVVVCC-------------------------------------V--------LFL--
IRE2_Mmus MARPVQRFQ-------------------------------------LWSP--L-GFLL--
IRE1_Mmus MPARWLLLL----------------------------------------------LAL--
ire-1_Cele MRATFHLFT-------------------------------------F-------IFLL--
IRE1_Scer MRLLRRNML-------------------------------------VL-T----LLVC--
IreA_Ddis MTFSKTRNK-------------------------------------II-F--L-LFLI--
IrlA_Ddis MTKPIFKSK-------------------------------------TK-P--L-GWSK--
IrlB_Ddis MNSLLNNLI---------------------------------------------------
IrlB_C2d_Ddis MNSLLNNLI---------------------------------------------------
IrlC_Ddis MKSNYST---------------------------------------YL-Y--K-MSE--L
IrlD_Ddis MGPKKGKRSHSKNHHHHNNGNNNNNNNSGGGSSSDILYTYSQDTRILL-F--K-VILTQN
IrlE_Ddis MGKKKIDIN----------------------------------TREDL-F--L-SY---Y
IrlF_Ddis MNFNFEQIL---------------------------------------------------
IrlF_C2d_Ddis MNFNFEQIL---------------------------------------------------
10577_Tthe MTDLKVVVS----------------------------------------E--L-KF----
IRE1_Spur MF----------------------------------------------------------
CC1G_06931_Ccin MAFVFFLQF----------------------------------------------LLL--
AqueK159_Aque MLARDQPRD----------------------------------------------FTWL-
AqueK160_Aque MLLVYRFSD-------------------------------------TF--------ESQ-
AqueK161_Aque YD----------------------------------------------------------
AqueK162_Aque PESS--------------------------------------------------------
AqueK163_Aque MSSSQEVVA-------------------------------------SL-SHSLPLFIIE-
AqueK164_Aque MYCQSLII----------------------------------------------------
AqueK165_Aque MVNLSRSLP---------------------------------------------EFLVD-
AqueK166_Aque MTDPDP------------------------------------------------SFSIN-
AqueK167_Aque MLELDSSLT------------------------------------------------IA-
AqueK168_Aque MNSSVPWLL-------------------------------------L--------FSV--
AqueK169_Aque MAQLAVFDG-------------------------------------GR---I----LNI-
IRE-2_Smoe MLKDFKPLF---------------------------------------------------
IRE-1_Smoe MLKDFKPLF---------------------------------------------------
IRE2_Hsap --Q-------F---AALLLGT----------------------L----------------
IRE1_Hsap --L-------L---PGL--GI----------------------F----------------
ire-1_Dmel --L-------A---SGLIASAT---AK-------------S-QQ----------------
IRE2_Mmus --Q-------L---VTL-LGK----------------------L----------------
IRE1_Mmus --L-------L---PPPGPGS----------------------F----------------
ire-1_Cele --L-------F---SSVIC-IS---TP-------------G-FR----------------
IRE1_Scer --V-------F---SSIIS-CS---IP-------------LSSR----------------
IreA_Ddis --I-------I---N-IF-NI----------------------N----------------
IrlA_Ddis --I-------S---S-K-------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ERI-------V---NG----------------------------------GDV-------
IrlD_Ddis EEIICMVIQIA---YGLP-GL----------------------PKISDISRDLGILILKL
IrlE_Ddis K-----------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe -----------------N-NE----------------------K----------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin --I-------V---GAVCWA-E---IV-------------N-VR----------------
AqueK159_Aque --S-------L---LASL------------------------------------------
AqueK160_Aque ------------QRI---------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque --E-------YEKLLAII-NIKLPPNPSQGPSHRFWDLFNA--H----------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque --H-------YMRLMAVV-GVKSGLEPDWSLSRRFLELYST--H----------------
AqueK166_Aque --R-------VILIIY--------------------------------------------
AqueK167_Aque --T-------SPS-----------------------------------------------
AqueK168_Aque --G-------F---FS-----C---LP-------------S-TD----------------
AqueK169_Aque ------------NDL---------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap SP----------------------------------------------------------
IRE1_Hsap GS----------------------------------------------------------
ire-1_Dmel GD-----------------------------------------------------S----
IRE2_Mmus GP----------------------------------------------------------
IRE1_Mmus GR----------------------------------------------------------
ire-1_Cele ND-----------------------------------------------------H----
IRE1_Scer TSRRQIVEDEVASTKKLNFNYGVDKNINSP---------------------IPAPRTT--
IreA_Ddis AY-------------------------------------------------I--------
IrlA_Ddis EV-------------------------------------------------I--------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis SSIFIEQDD---------------------------------------------------
IrlD_Ddis PNRTIRELELFLESKNIYFREDQHINYLNEIPQPTTTTTSPPPPPPPSSIST--------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe QQQ---------------DN-------------------------------Y--------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ST-------------------------------------------------IPAAETAAL
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque AA----------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque AS----------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque SD----------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------QVH-TLRP----
IRE1_Hsap ------------------------------------------------TST-VTLP----
ire-1_Dmel -----------------------------------AEVVSSGEDEKTDCTDLARDE----
IRE2_Mmus ------------------------------------------------QVQ-SVRP----
IRE1_Mmus ------------------------------------------------TST-VTLP----
ire-1_Cele --------------------------------------------E--SIGDDEEKT----
IRE1_Scer --EGLPNMKLSSYPTPNLLNTADNRRANKKGRRAANSISV-PYLENRSLN--ELSL----
IreA_Ddis -------------------------------------------------KDE-NED----
IrlA_Ddis -------------------------------------------------NED-EEEEEGG
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis -------------------------------------------------TTT-TTT----
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe -------------------------------------------------GME-DQHST--
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin IQRTRPA----------------------------PTYATGGILE--PTK--DLEL----
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque --------------------------------------------Q--KGS----------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque --------------------------------------------K--K------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque --------------------------------------------Q--SSSDIALAY----
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ---------------------------------------------------ENLLLVS--
IRE1_Hsap ---------------------------------------------------ETLLFVS--
ire-1_Dmel ---------------------------------------------------EALMVFS--
IRE2_Mmus ---------------------------------------------------ESLLFVS--
IRE1_Mmus ---------------------------------------------------ETLLFVS--
ire-1_Cele ---------------------------------------------------SSTILVS--
IRE1_Scer ---------------------------------------------------SDILIAA--
IreA_Ddis ---------------------------------------------------DLSLLIS--
IrlA_Ddis EEGGEEEEIDNNKNSNNSSSNSNNNNNDNNNNNGEERKVEKEEEKEEINHYRNQFEKD--
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ---------------------------------------------------ATAIEIESS
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ---------------------------------------------------ELS-IAG--
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ---------------------------------------------------LDIVLVA--
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ---------------------------------------------------SLEVAVT--
AqueK164_Aque ---------------------------------------------------------D--
AqueK165_Aque ---------------------------------------------------SPQVAAS--
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ---------------------------------------------------KDLLLFS--
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe --------------------------------------------------------XX--
IRE-1_Smoe --------------------------------------------------------FQ--
IRE2_Hsap ------TLDGSLHALS-KQTG---------------------------------------
IRE1_Hsap ------TLDGSLHAVS-KRTG---------------------------------------
ire-1_Dmel ------TLGGGLTAID-PVTS---------------------------------------
IRE2_Mmus ------TLDGSLHALN-KQTG---------------------------------------
IRE1_Mmus ------TLDGSLHAVS-KRTG---------------------------------------
ire-1_Cele ------TIDGRLRALD-SETG---------------------------------------
IRE1_Scer ------DVEGGLHAVD-RRNG---------------------------------------
IreA_Ddis ------TLDGNIYSFN-YESG---------------------------------------
IrlA_Ddis ------LLDMELKALN-RETIDNILSGL--------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis SGLTSNITDSTEIQLD-STTTDTKTT-STTSTTTNNSSDSNNNNNNNNNNNSNNILNFPF
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------SIDGKFHALS-RSTG---------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------YLYTILNGLEWKELA---------------------------------------
AqueK164_Aque ------QLDERA------------------------------------------------
AqueK165_Aque ------YVDKLLTGLGYEEMG---------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------TLDGKLYAVD-KVTG---------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------XXXXXXXXXX-XXXX---------------------------------------
IRE-1_Smoe ------RTDYSLTCFE-VSTG---------------------------------------
IRE2_Hsap ----------------------DLKW--TLRDDPVIEG----------------------
IRE1_Hsap ----------------------SIKW--TLKEDPVLQV----------------------
ire-1_Dmel ----------------------EIRW--TIADDPPIVA----------------------
IRE2_Mmus ----------------------DLKW--TVKDDPIIQG----------------------
IRE1_Mmus ----------------------SIKW--TLKEDPVLQV----------------------
ire-1_Cele ----------------------EIKW--TLQEEPVLRS----------------------
IRE1_Scer ----------------------HIIW--SIEPENF----------Q--------------
IreA_Ddis ----------------------ELNW--DLKPNGGD----SLYST-SQFD----------
IrlA_Ddis ---------------NSYEIFKEVNF--DFEKLYSI----IISEPPPLFD--------T-
IrlB_Ddis ---------------------IDYEY--DLIKVHHH----IQKN-IFIFP----------
IrlB_C2d_Ddis ---------------------IDYEY--DLIKVHHH----IQKN-IFIFP----------
IrlC_Ddis ----------------VLGEIKNFNY--DLYTKYDSL---VLKD-PQTQN----------
IrlD_Ddis NCQNKSKQKRPISKEESFNKMVQYNF--DLGKIFDE----FTRE-VLLDDLKNDLKIDNI
IrlE_Ddis -------------------EIEKNKF--DLLKIC--------SD-KN-------------
IrlF_Ddis ----------------------EYNF--DFKKLHKN----KLKN-NNLSE----------
IrlF_C2d_Ddis ----------------------EYNF--DFKKLHKN----KLKN-NNLSE----------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ----------------------KILW--SMPAFARAEGSSTLSSLA--------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------ET----------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ----------------------KLKA--FIKNDVKVDV----------------------
AqueK164_Aque --------------------------------A---------------------------
AqueK165_Aque ----------------------EFSVYRYLHTEVDLDS----------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ----------------------DTLW--KLNSKSPIVT----------------------
AqueK169_Aque ------------------------------------N-----------------------
IRE-2_Smoe ----------------------XXXX--XXXXXXXX------------------------
IRE-1_Smoe ----------------------SVKW--TIRFSEVA------------------------
IRE2_Hsap --------------------------PM--------------------------------
IRE1_Hsap --------------------------PT--------------------------------
ire-1_Dmel ---------------EH---------QE--------------------------------
IRE2_Mmus --------------------------PM--------------------------------
IRE1_Mmus --------------------------PT--------------------------------
ire-1_Cele --------------------------PS--------------------------------
IRE1_Scer ----------PLIE-IQE--------PS--------------------------------
IreA_Ddis --------------RKQQQ-STSTSTEI--------------------------------
IrlA_Ddis ------------FFDSVSS-FEIFFTDCLILLCSNFPDGIDTSI----------------
IrlB_Ddis --------------FKKQH-YHSTVLECLINLCSKLKYDENENLN---------------
IrlB_C2d_Ddis --------------FKKQH-YHSTVLECLINLCSKLKYDENENLN---------------
IrlC_Ddis ------------NSPKPPS-LEIFILVNLIALCGRI----NDKFP---------------
IrlD_Ddis PIDNISISPTPIISPVFQE-YDLFLMDSFIILCGQL----DNVKL---------------
IrlE_Ddis ------------FSKSNFL-KAVHCLFSLSYFCKIK--DENEEEEGKEEEINDYKVKKST
IrlF_Ddis ---------------NEDD-YATTVIECLIHLCEVIPT--NKIY----------------
IrlF_C2d_Ddis ---------------NEDD-YATTVIECLIHLCEVIPT--NKIY----------------
10577_Tthe ------------------------NQES--------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ----------PLVR-TTHPENDPDDFDD--------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque --------------------------HCTV------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque --------------------------HL--------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap -----------------------------------------YVT-EM-A---FLSDP-AD
IRE1_Hsap -----------------------------------------HVE-EP-A---FLPDP-ND
ire-1_Dmel -----------------------------------------NVQ-VP-H---FLPDP-RD
IRE2_Mmus -----------------------------------------YVT-EM-A---FLSDP-AD
IRE1_Mmus -----------------------------------------HVE-EP-A---FLPDP-ND
ire-1_Cele -----------------------------------------AVKQGF-T---FLPNP-LD
IRE1_Scer -----------------------------------------RLETYE-T---LIIEPFGD
IreA_Ddis -----------------------------------------TKS-SP-S---ILIPT-LD
IrlA_Ddis ---------------------------------TRPNFN-DFYN-HF-KDRGVINK----
IrlB_Ddis ---------------------------------SLDQFKIIFYN-ES-K---FLNKN-LK
IrlB_C2d_Ddis ---------------------------------SLDQFKIIFYN-ES-K---FLNKN-LK
IrlC_Ddis ---------------------------------NLDKFLTH-YK-YATNIFNLLSEN-II
IrlD_Ddis ---------------------------------TLEEFKDY-YK-KY----KLLNQ----
IrlE_Ddis TGNYYRNSEGKLFKKSNEKDQIDDVSIFYKRLPTIQDFKDT-YD-KYEN---CLN-----
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe -----------------------------------------NFE-RY-D---YFLPS-SD
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin -----------------------------------------DT-TPE-T---YIIEP-QS
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque --------------------------------------------------------S-VD
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque -----------------------------------------SSS-SY-L---YLTDP-KD
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap G-----------------------------------------SLY-------ILGTQKQQ
IRE1_Hsap G-----------------------------------------SLY-------TLGSKNNE
ire-1_Dmel G-----------------------------------------SIY-------QLGQ--MG
IRE2_Mmus G-----------------------------------------SLY-------VLGTQKQQ
IRE1_Mmus G-----------------------------------------SLY-------TLGGKNNE
ire-1_Cele G-----------------------------------------SLY-------VL---KNS
IRE1_Scer G-----------------------------------------NIY-------YFNA--HQ
IreA_Ddis G-----------------------------------------SGL-------LFQY-SND
IrlA_Ddis -YIS----RENIHK-ALNDKLMTDYFNS--GIYLGLLDTLDI--AAIRFITIFGKF-LSY
IrlB_Ddis EYLE----ILKNSK-EINKHVICDYFEK--D-NNGSEEKNQNSSIVFNFLNCFKDY-LSM
IrlB_C2d_Ddis EYLE----ILKNSK-EINKHVICDYFEK--D-NNGSEEKNQNSSIVFNFLNCFKDY-LSM
IrlC_Ddis NSIEKFKETLSKDLPSFQLSVIA----------NSSIVKKDN--SIIKFLSCFGSF-MKL
IrlD_Ddis -YIEDFKDNLINDF-LVTVEILA----------SWYIPQKDY--SIVKFINCFGEM-LDS
IrlE_Ddis SVYYIIRKIKLLHL-EYFWEILA----------SCY---GTI--SFIKFFNIFSNE-I-F
IrlF_Ddis -------------------------------------------SGANKFISCFYEF-MNE
IrlF_C2d_Ddis -------------------------------------------SGANKFISCFYEF-MNE
10577_Tthe G-----------------------------------------NFI-------FLAS-DST
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin G-----------------------------------------HIY-------VVNS-EDD
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque --------------------------------------------------------KVTE
AqueK164_Aque DSLY----------------VWAGYQDGLPG-VHDSEEKRKVTSNIQHFTPSSGQW-IT-
AqueK165_Aque --------------------------------------------------------KVNE
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque G-----------------------------------------SLY-------MSGP-QSD
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap G-LM-------KLPFT--------------------------------------------
IRE1_Hsap G-LT-------KLPFT--------------------------------------------
ire-1_Dmel S-LK-------KLPYT--------------------------------------------
IRE2_Mmus G-LM-------KLPFT--------------------------------------------
IRE1_Mmus G-LT-------KLPFT--------------------------------------------
ire-1_Cele S-LK-------KLPFN--------------------------------------------
IRE1_Scer G-LQ-------KLPLS--------------------------------------------
IreA_Ddis R-LH-------QVPFS--------------------------------------------
IrlA_Ddis EVVE-------TISNS-------LFRYRTDKIEF-----------------LSDIIRELL
IrlB_Ddis DIIE-------FIVRGISFQVRSYCNLIKPIEQWKQKTYQQRYQQFKKALHLNNEVYKRI
IrlB_C2d_Ddis DIIE-------FIVRGISFQVRSYCNLIKPIEQWKQKTYQQRYQQFKKALHLNNEVYKRI
IrlC_Ddis ESIE-------YFGSV-------FNSLIGEEDQFSLDLLQ-------VLIDSSNEYKKFL
IrlD_Ddis TIIE-------SFSYI-------FNKTIKKEDDWSISFIQ-------AALGSNEEFKRQV
IrlE_Ddis SPSENGDSVFIMVGKF-------FRRKVRAETHYDLIFLK-------IIL-ANASI-PMI
IrlF_Ddis RFIE-------TLVLE-------FYDLMTTD---NSKVTTGIFDQFFSLIKKSDIIYKSF
IrlF_C2d_Ddis RFIE-------TLVLE-------FYDLMTTD---NSKVTTGIFDQFFSLIKKSDIIYKSF
10577_Tthe P-IK-------IMRDE--------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin S-LQ-------RFPFS--------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque K-VD-------H------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque A-LT-------RVKND--------------------------------------------
AqueK164_Aque ---R-------STTGTPPLGVRS-------------------------------------
AqueK165_Aque K-LE-------KLMKF--------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque G-IK-------RLPLT--------------------------------------------
AqueK169_Aque E-LI-------R------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis LCNEKY----RT----------------LSKSYDLVQKRLQKEEFTFIKVFEDDDPKLF-
IrlB_Ddis VCNGVW----KSEKLDYI-YRYKS------------------DQLSLVGIIESDCSDLFI
IrlB_C2d_Ddis VCNGVW----KSEKLDYI-YRYKS------------------DQLSLVGIIESDCSDLFI
IrlC_Ddis QIL----------EFNQLQKYYD------------------DGHLCLFHSIKFDNLNEFK
IrlD_Ddis MCL----------NDELIQDRYD------------------QSLYSIMHPIKFDNVREFI
IrlE_Ddis LKLGVKDIGRFTEKEDII-VSYY-------------------RNFSIIHSLRFDNVKEFA
IrlF_Ddis Y---EW----DSNILENR-FIFKNNNNNIDGDDDDGNEDDYFGRFSILSILEDDNSHII-
IrlF_C2d_Ddis Y---EW----DSNILENR-FIFKNNNNNIDGDDDDGNEDDYFGRFSILSILEDDNSHII-
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ----------------------------------------------------------IP
IRE1_Hsap ----------------------------------------------------------IP
ire-1_Dmel ----------------------------------------------------------IP
IRE2_Mmus ----------------------------------------------------------IP
IRE1_Mmus ----------------------------------------------------------IP
ire-1_Cele ----------------------------------------------------------IP
IRE1_Scer ----------------------------------------------------------IR
IreA_Ddis ----------------------------------------------------------LQ
IrlA_Ddis SALYQPPDIIKLITEP------------------------EKDSGFWCMIGIFKSKRILD
IrlB_Ddis STLLID------SNSY------------------------EQLENVWRLICNFDSFSIAS
IrlB_C2d_Ddis STLLID------SNSY------------------------EQLENVWRLICNFDSFSIAS
IrlC_Ddis LLFN-D------STWCQQQ----------------QQQQQINPQIFWFILCKYNSSKIAH
IrlD_Ddis LIYSRD------ENY-------------------------FEPQEFWYLICKYDAIAITQ
IrlE_Ddis LVYKTL------KNNYPSKKKKKITLFEENGKINVKTS--KKDLMLFEFVCKFDCVKIFK
IrlF_Ddis SNYFKF-------TNY------------------------ERLEDLWIMICHYQATDIAK
IrlF_C2d_Ddis SNYFKF-------TNY------------------------ERLEDLWIMICHYQATDIAK
10577_Tthe ----------------------------------------------------------ID
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ----------------------------------------------------------MA
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ----------------------------------------------------------LP
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ----------------------------------------------------------RP
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ----------------------------------------------------------IP
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ELV-HASPCRSS-----------------------------DGVFYT------------G
IRE1_Hsap ELV-QASPCRSS-----------------------------DGILYM------------G
ire-1_Dmel QLV-ANAPCRSS-----------------------------DGILYS------------G
IRE2_Mmus ELV-HASPCRSS-----------------------------DGVFYT------------G
IRE1_Mmus ELV-QASPCRSS-----------------------------DGILYM------------G
ire-1_Cele QLV-HASPCKGN-----------------------------DGILYA------------G
IRE1_Scer QLV-STSPLHLKTN----------------IVVNDSGKIVEDEKVYT------------G
IreA_Ddis ELV-NTSPLFLKELEDKSSTSSTSTTSESSK-------DENKVTMFI------------G
IrlA_Ddis YLI-RTEPSKS---------------------------------WFK------------G
IrlB_Ddis KFLIEFFKLDK-----------------------------------VNNKLNFSIHPSSD
IrlB_C2d_Ddis KFLIEFFKLDK-----------------------------------VNNKLNFSIHPSSD
IrlC_Ddis YLL-NDYQI------------------------------------------------NK-
IrlD_Ddis HII-NNNIA------------------------------------------------EED
IrlE_Ddis KYFLPKPQI-------------------------------------INNNDN-----NEM
IrlF_Ddis ALF-NLYY---------------------------------------------------D
IrlF_C2d_Ddis ALF-NLYY---------------------------------------------------D
10577_Tthe QVI-KICPMS-----------------------------GNESKYI-------------A
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ELV-DMSPFTSPG--------------------------DDEKRVFI------------G
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque KRI-I-------------------------------------------------------
AqueK164_Aque ------YC---------------------CT-------SINDQLYYF------------G
AqueK165_Aque AVL-Q-------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ELV-KISPCSSS-----------------------------DGLLYS------------G
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap R-KQDAWFVVDP-----ESGETQM----------------TLTTE---------------
IRE1_Hsap K-KQDIWYVIDL-----LTGEKQQ----------------TLSSAF-----AD-------
ire-1_Dmel K-KSDTWYMVDP-----KTGRREK----------------VMGFGDA---TVD----GKE
IRE2_Mmus R-KQDAWFVVDP-----ESGETQM----------------TLTTE---------------
IRE1_Mmus K-KQDIWYVIDL-----LTGEKQQ----------------TLSSAF-----AD-------
ire-1_Cele S-KKDVWFGIDP-----KTGLKVEYILLNISDKILFLQVETLSSA-----SAD-------
IRE1_Scer S-MRTIMYTINM-----LNGEIIS----------------AFGPGSKNGYFGSQSVDCSP
IreA_Ddis N-KKTSITVVDS-----QTGEIIK----------------SMSKDGL---WLT-------
IrlA_Ddis K-ESDYFFSI--------------------------------------------------
IrlB_Ddis A-NENYKR----------------------------------------------------
IrlB_C2d_Ddis A-NENYKR----------------------------------------------------
IrlC_Ddis ---KS-L-----------------------------------------------------
IrlD_Ddis LSKRS-GKTY--------------------------------------------------
IrlE_Ddis LE-CI-SSGS--------------------------------------------------
IrlF_Ddis S-KEDCISVF--------------------------------------------------
IrlF_C2d_Ddis S-KEDCISVF--------------------------------------------------
10577_Tthe F-TKEKILLVNP-----ENGELEK----------------FEDIEDD---YEN-------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin R-KETSLLLLEL-----ETGRIKA----------------TLNSECP--PYDDRRIDLDE
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ----------DLGD---QLGE---------------------------------------
AqueK164_Aque G-----------------------------------------------------------
AqueK165_Aque ----------VVRELCLCLHD---------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque S-KQDSWIAVDA-----LTGRKLY----------------SFSSHD----GMN-------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap -------G-----PSTPRLYIGR-TQYTVTM---HDPRAP-----ALRWNTTYR-RYSAP
IRE1_Hsap -----SLC-----PSTSLLYLGR-TEYTITM---YDTKTR-----ELRWNATYF-DYAAS
ire-1_Dmel G---EQIGW----ATSRAIYLGR-TQYTVMM---YDSLAKNKD--AKPWNITFY-DYNAV
IRE2_Mmus -------G-----LSTPQLFIGR-TQYTVSM---HDLRTP-----ALRWNTTYR-RYSAP
IRE1_Mmus -----SLC-----PSTSLLYLGR-TEYTITM---YDTKTR-----ELRWNATYF-DYAAS
ire-1_Cele -----RICPAN---QKQTIFLGR-TEYRVSM---FDEKNR-----GKTWNATFN-DYSAH
IRE1_Scer E---EKIKL---QECENMIVIGK-TIFELGI---HSYD--G-----ASYNVTYS-T----
IreA_Ddis ---DEDDCPVNI-IPDEALMFTR-SDYQIIA---LDPKSG-----VEKWNLSVG-EYIPH
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ---Y-----------LNHYIINI-NQKLIKQ---LNIFTK-----RENWALTST-DVNLM
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin LEEPESRG-----SSTTEVFIGR-TDYYISI---YPHRSKGYGTRAPVQNLSFS-VYGPN
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque -------------------VIE--------------------------SIG-----SLH-
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------YQLSR-YRLAVSVLTNRDLISPGVP-----FNEVYE-DI---
AqueK164_Aque -------------------YCGHDYCYHNSI---TQLDTV-----SLQWRELEPTDATRP
AqueK165_Aque ------------------YQVER-YRMVVTLLR-----RTALD-----SNKSFL-ELFMD
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque -----SMCPPNQYGSNKIIHIPS-IEYRVAV---LDSKTK-----QIKVNITYT-QYGTQ
AqueK169_Aque -------------------LLER-YHFNKTL---YDRLG--LR-----LKL-FY-NTLEK
IRE-2_Smoe -----------------------------------------------------------X
IRE-1_Smoe -----------------------------------------------------------N
IRE2_Hsap P----MDGSPGK------YM-SHLASCGMG-LLLTVDPG---SG----------------
IRE1_Hsap L----PEDDVDY------KM-SHFVSNGDG-LVVTVDSE---SG----------------
ire-1_Dmel S--APPELAKEY------EY-IHLTTTTNG-QIVTLDRK---HG----------------
IRE2_Mmus L----LNGSPGK------YM-SHLTSCGMG-LLLTVDPG---SG----------------
IRE1_Mmus L----PEDDVDY------KM-SHFVSNGDG-LVVTVDSE---SG----------------
ire-1_Cele L----LPEVNTW------PF-KHYASSSHG-YILTFDRE---TG----------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis S--T-----KSF------YN-SEISLNFEG-LIEVASLS--QRMYKIYIKKPEKTVVGIS
IrlA_Ddis --------------------------------------------AEMGGKYF--------
IrlB_Ddis ---T-----KTS------TN-SNLSIDLVR-LLEFTTTNFSINVAKLLISKF--------
IrlB_C2d_Ddis ---T-----KTS------TN-SNLSIDLVR-LLEFTTTNFSINVAKLLISKF--------
IrlC_Ddis -----------K------QK-NPLEISPVT-LLEIAFLCFSDKIAIVLFSQ---------
IrlD_Ddis ---N-----SNL------SE-NPLEINPLS-LLEICSANFSHKIASILFQF---------
IrlE_Ddis ---Y-----SGF------DEKSKRKIR--I-FFSICCRQISPKILKCIVDY---------
IrlF_Ddis ---A-----SDD------NN-NKISISILR-ILEITSIEFSLPVLTVIVENT--------
IrlF_C2d_Ddis ---A-----SDD------NN-NKISISILR-ILEITSIEFSLPVLTVIVENT--------
10577_Tthe I-----------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin N--EDNLLQANYRRTSDDAY-IQGFPNGDV-YSFKTKSE---GGRV------------QT
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque L----LKKCG--------------------------------------------------
AqueK164_Aque VMRR-----GHG------GM-ISFEHDGVH-HLLMIGGG-------------------GG
AqueK165_Aque L----TQELG--------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque S--------------------------------YTARQS---QG----------------
AqueK169_Aque I----KKDHG--------------------------------------------------
IRE-2_Smoe X----XX-XXXX------XX-X-XXXXXxSLTLLVSDGK---PS----------------
IRE-1_Smoe L----AE-DIDY------PG-I-AAGNTTSLTVLVSDGK---PS----------------
IRE2_Hsap TVLWTQD-LGVPVMGVYTWHQ-----------DGLRQLPHL-------------------
IRE1_Hsap DVLWIQN-YASPVVAFYVWQR-----------EGLRKVMHI-------------------
ire-1_Dmel KFLWQRD-LSSPVVAAFLLGP-----------DGLLSVPFT-------------------
IRE2_Mmus IVLWTQD-LGVPVTGIYTWHQ-----------DGLHQLPHL-------------------
IRE1_Mmus DVLWIQN-YASPVVAFYVWQG-----------EVLRKVVHI-------------------
ire-1_Cele EMRWEQD-LKQPVVALYLLRD-----------DGLHKLPFE-------------------
IRE1_Scer ---WQQNVLDVPLALQNTFSK-----------DGMCIAPFR-------------------
IreA_Ddis HNYWEHI-LTSSPVSIYAYSS---------KKHILKKLDFHRKVSPYSNSLIPVASTDLM
IrlA_Ddis ----NWT-LL-EPKLIKKEVN---------QKS---------------------------
IrlB_Ddis ------------PTFITSIPS---------RNS---------------------------
IrlB_C2d_Ddis ------------PTFITSIPS---------RNS---------------------------
IrlC_Ddis ------------FNYHELLPK---------KSK---------------------------
IrlD_Ddis ------------YDFKDSMPT---------RFS---------------------------
IrlE_Ddis ------------V------KD---------DIG---------------------------
IrlF_Ddis ------------PNFLNSIPT---------KTS---------------------------
IrlF_C2d_Ddis ------------PNFLNSIPT---------KTS---------------------------
10577_Tthe --YED----------------------------FLYKGLQK-------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin QPLWVQK-FHAPTVAVFDVLR---------GSTPLQPHPHA-------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ---------SYPVAIAF-------------------------------------------
AqueK164_Aque S----KP-AVQLPHYK--YIKKSNGNWRTNEHS----------MYNLSSRK---------
AqueK165_Aque ---------KYPLAVAL-------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque DKVWEKD-FGSPVVGIYSLEK---------S-QVLRSIPFT-------------------
AqueK169_Aque KI---DD-CFIECLASW-------------------------------------------
IRE-2_Smoe K-----------------------------------------------------------
IRE-1_Smoe K-----------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis IPSNFDRTFMFDDYYGQLFIVSPPSNNNN---NNNNNNNNN--NNNNNNNNNNNNNNNNN
IrlA_Ddis -------------LKGVIPPR--ELNSQQRNTQFFRVFNGVTGFNDI-------------
IrlB_Ddis -------------LWGIESRS--SLNPIE---NHFRILNCSFDFNNH-------------
IrlB_C2d_Ddis -------------LWGIESRS--SLNPIE---NHFRILNCSFDFNNH-------------
IrlC_Ddis -------------MKHLIKST--STLINN---NNNNNNNNNNNNNNNNNNNNNNNNNNNN
IrlD_Ddis -------------LRGVFKPT--TTT-TT---TTTTTT-TTTTTIDKDE-KDKENNNNNV
IrlE_Ddis -------------FLDLQNRQ--DI----------------------------------Y
IrlF_Ddis -------------MLGMKFKL--HNNNNN---NNNNNNNNNNNNNNNNNNNNNNNNNNNN
IrlF_C2d_Ddis -------------MLGMKFKL--HNNNNN---NNNNNNNNNNNNNNNNNNNNNNNNNNNN
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque -----------------------WSNP---------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis NNNNKNN-NNNNKNESDKSNLTPLTPYDPSKPNGANNNNNNNN--------------DL-
IrlA_Ddis ------------------------------------------RFVYANP-----------
IrlB_Ddis ----------------------------------------------------------Q-
IrlB_C2d_Ddis ----------------------------------------------------------Q-
IrlC_Ddis NSKNIG-LT----------------------------------------QYTVLEGYFLI
IrlD_Ddis ISQQF---Q----------------------------------------YFRVLDVNCYF
IrlE_Ddis ----IGDSA----------------------------------------PEKVLFLNCFF
IrlF_Ddis NNNNINK-NNNDNGNGKAENIYRLSG-----DCKEKEKYDNNYSRETEIPFKVFDTKFL-
IrlF_C2d_Ddis NNNNINK-NNNDNGNGKAENIYRLSG-----DCKEKEKYDNNYSRETEIPFKVFDTKFL-
10577_Tthe --------NQLTENEDYIFMQD--------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque -----SI-IGQC------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis --LDSNKLKNYDIYLYSSIVILITSI----------------------------------
IrlA_Ddis --SLAQHAIKFIQKVTECGLFLNTDV----------------------------------
IrlB_Ddis --IPIDKQKDYINLFTKNLIHFNTEI----------------------------------
IrlB_C2d_Ddis --IPIDKQKDYINLFTKNLIHFNTEI----------------------------------
IrlC_Ddis NIRTRSRIAPFIEVLTMNGIHLTNDIIHTRIKSMSSDSIFRIFTEQYQQQQQNPLNNNQK
IrlD_Ddis NDVIKKRAPIFIDLMTQSNIYLNTEV----------------------------------
IrlE_Ddis GNHKEQRVIDFFNLLTSKSIIICNTI----------------------------------
IrlF_Ddis --ITTMECSDYIRFFTSSSIIFNTEV----------------------------------
IrlF_C2d_Ddis --ITTMECSDYIRFFTSSSIIFNTEV----------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis --------------------RNV--RDSIP-N----------------------------
IrlB_Ddis --------------------NEI--EDLIL-K----------------------------
IrlB_C2d_Ddis --------------------NEI--EDLIL-K----------------------------
IrlC_Ddis QIQFNENFTRQQKIDFDNCPNEI--DTFI-LDKTQCNLITLSQEFSIKVRAFTFYLSFGE
IrlD_Ddis --------------------GEG--SDEN-VD----------------------------
IrlE_Ddis --------------------KEK--PEL--YD----------------------------
IrlF_Ddis --------------------NQTCYDDLKLIQ----------------------------
IrlF_C2d_Ddis --------------------NQTCYDDLKLIQ----------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------IP----------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis -------------------------------------------SNS-----------FL-
IrlB_Ddis -------------------------------------------ERY-----------HI-
IrlB_C2d_Ddis -------------------------------------------ERY-----------HI-
IrlC_Ddis IFTCSCEDYKREFSCKHMFFILLNYYHVPRNSYLIYQRQFTEIERYSIIMNIDLSKINSR
IrlD_Ddis --------------------------------------------------------THES
IrlE_Ddis -------------------------------------------YR-----YITLSTVDST
IrlF_Ddis -------------------------------------------KRL-----------GF-
IrlF_C2d_Ddis -------------------------------------------KRL-----------GF-
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque -------------------------------------------PTY-----------GF-
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap -------------------------T--LA------------------------------
IRE1_Hsap -------------------------N--VA------------------------------
ire-1_Dmel -------------------------T--VS------------------------------
IRE2_Mmus -------------------------T--LA------------------------------
IRE1_Mmus -------------------------N--VA------------------------------
ire-1_Cele -------------------------V--MG------------------------------
IRE1_Scer -------------------------DKSLL------------------------------
IreA_Ddis -----------IVFIRSK---KNFNL--INV-----NNNNNQNNNQNSNQNNNINNKKT-
IrlA_Ddis ----------------------FRKF--LEV-----NF------FYRYEKDNEVYQ----
IrlB_Ddis -----------SIRS-------------INN-----NNHDDDDYD-DYDDDDDHHSGCNN
IrlB_C2d_Ddis -----------SIRS-------------INN-----NNHDDDDYD-DYDDDDDHHSGCNN
IrlC_Ddis IYGTPNFNTFFKIKSSPSSTTSPFQS--INN-----NNNNNLNN---------------N
IrlD_Ddis IYSFQN-----------------------------------------------------S
IrlE_Ddis FYF-----------SDSH-KGADFGV--YTDEINVIINNDDIDYD-YIGD---------D
IrlF_Ddis -----------LIYSNSNKFTYPFDF--WNN-----NNNNNNNNNNNNNNNNNNNNNNNN
IrlF_C2d_Ddis -----------LIYSNSNKFTYPFDF--WNN-----NNNNNNNNNNNNNNNNNNNNNNNN
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin -------------------------F--VL------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque -----------ITEKI--------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque -------------------------S--IN------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis --------HQ---PTEENSL-----------LYSTSIISRIVEMEVTD------------
IrlB_Ddis NNNNNNDGDH---NEDENSIKEESL-IEFSNYKVDSMISRLLKYNAPS------------
IrlB_C2d_Ddis NNNNNNDGDH---NEDENSIKEESL-IEFSNYKVDSMISRLLKYNAPS------------
IrlC_Ddis NNNNLNNNNNNENENKFKEDGDDEILQNL--NRLNYILLRDFEFGPNDITTKLRETHINL
IrlD_Ddis TEYLAINS---NSIHRLKRSS-------------ISLLSKVLEFND--------------
IrlE_Ddis DNDEEIE---ETKDYGSSSSDIDD-FYNVF-EPKASMIPNILDSCS--------------
IrlF_Ddis NNNNNNNNNN---NNNNNKNDDDEL-EKLVEYRKGSLISLVFSFAGYR------------
IrlF_C2d_Ddis NNNNNNNNNN---NNNNNKNDDDEL-EKLVEYRKGSLISLVFSFAGYR------------
10577_Tthe ---------Q---HQDLKIKQKQSK-IKIVDFQTDQEI----------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ----------RDTLHFLAL--RWGHIRL-P-AS----GPRDTATLFSTLDTQ--------
IRE1_Hsap ----------VETLRYLTF--MSGEVGR---IT----KWKYPFPKETEAKSK--------
ire-1_Dmel ----------DEAYQAILE--ES-KTGN---V----------------NTVK--------
IRE2_Mmus ----------RDTLHFLVL--RWGHIRL-P-AS----SYQDTATQFSSLDTQ--------
IRE1_Mmus ----------VETLRYLTF--MSGEVGR---IT----KWKYPFPKETEAKSK--------
ire-1_Cele ----------KETMENVAK--NIFTVDQWPTVL----GVNAADPQTTSLTNQ--------
IRE1_Scer ----------ASDLDFRIA--RWVSPTF-P-------GI---------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------LLS--------VVLK---NLT----QQGCS----------LARE----
IrlB_Ddis -----------TTII--------ALLS---NLV----CNHMG----------VSQRILIL
IrlB_C2d_Ddis -----------TTII--------ALLS---NLV----CNHMG----------VSQRILIL
IrlC_Ddis FDRLLLIEDNLEALD--------KILK---NFT----QKGCT----------LSRD----
IrlD_Ddis ----------RDTLI--------SLLK---NLT----QGGCT----------LCKD----
IrlE_Ddis ----------LEILK--------AYIQ---NIT----GNGLF---------KISPS----
IrlF_Ddis -----------FFSS--------YIIE---NLT----GTNIG----------NPNYVFDI
IrlF_C2d_Ddis -----------FFSS--------YIIE---NLT----GTNIG----------NPNYVFDI
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ----------LQ-----------------------------PRPRAEDVIPG--------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque -------------IIGVLERSGWGDTRR---LKPFADRSVDFNTRFSKVDLC--------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque -------------TIGVLEKSDWGDTGK---LKPFSLPNFDLNTSYPEVDLC--------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ----------DDTLQGMTA--SR--------AL----AIKNGLYSLTPTDTI--------
AqueK169_Aque -----------------LRKAD-----------GVETP---------TIDTL--------
IRE-2_Smoe ---------------------------------------------RKFQGTK--------
IRE-1_Smoe ---------------------------------------------RTFQGTK--------
IRE2_Hsap ----------LL-------MTLYV-GK--D--ETGF-YVSK-----AL------------
IRE1_Hsap ----------LT-------PTLYV-GK--Y--STSL-YASP-----SM------------
ire-1_Dmel ----------LF-------QSLYV-GE--H--QKGL-YALP-----SL------------
IRE2_Mmus ----------LL-------MTLYV-GK--E--EAGF-YVSK-----AL------------
IRE1_Mmus ----------LT-------PTLYV-GK--Y--STSL-YASP-----SM------------
ire-1_Cele ----------FF-------PALFV-GE--S--SFGL-YAIE-----AL------------
IRE1_Scer ----------------------IV-G--------LF-DVFN-----DL------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis --AVDERS--LL-------STIHS-DK--YYNSSIV-VLHNYWPIPPKFCDCSTSFISMA
IrlB_Ddis STLIEEIQ--MI-------ESLLV-QN--DSFKTFM-LCESMVSTPNR------------
IrlB_C2d_Ddis STLIEEIQ--MI-------ESLLV-QN--DSFKTFM-LCESMVSTPNR------------
IrlC_Ddis --LVGDRN--LL-------VLVAILDS--TSKEKLS-LLNKYWPLPEK------------
IrlD_Ddis --LIDEKQ--LL-------ITISRPQY--HQSIQIL-HQNGYTIIPKY------------
IrlE_Ddis --LFLAHDVTRL-------VRNPKPKT--ETVVKILEFINTISRLSE-------------
IrlF_Ddis SELMTDFE--II-------RGLLL-SK--Y--FSIL-FKSRKFTVPTL------------
IrlF_C2d_Ddis SELMTDFE--II-------RGLLL-SK--Y--FSIL-FKSRKFTVPTL------------
10577_Tthe -------------------IAIFS-AV--G--FTNM-FQKN-----VI------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ----------LDRSLLRGAKSAYV-GMVEE--TGSL-YAMS-----PS------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque --------------------L---------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ----------LT-------VADYY-GN--M--SDRD-FSSA-----KV------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ----------LT-------VAGYY-GY--M--RDID-FSNA-----KV------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ----------LQ-------SSFFV-GD--H--NGQM-YVMN-----AL------------
AqueK169_Aque ----------IA-------ALREI-GE--N------------------------------
IRE-2_Smoe ----------FT-------PIIVE-PP--Y------------------------------
IRE-1_Smoe ----------FT-------PIIVE-PP--Y------------------------------
IRE2_Hsap ---------VHT---GV-A---LVP-----------------------------------
IRE1_Hsap ---------VHE---GV-A---VVP-----------------------------------
ire-1_Dmel ---------VDK---NT-P---RIS-----------------------------------
IRE2_Mmus ---------VHA---GV-A---LVP-----------------------------------
IRE1_Mmus ---------VHE---GV-A---VVP-----------------------------------
ire-1_Cele ---------VDH---QTIT---YSP-----------------------------------
IRE1_Scer ---------RTN---EN-I---LVP-----------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis NGKLPRTYSGSDGVIPYIFFARNH-LTLGF-----------LLSIH--NNITDTIDINHW
IrlB_Ddis ---------WSKQSIPLVFFAYIGSDI--LNLKERPMFYK-FFDLNP-RLLLSIIP----
IrlB_C2d_Ddis ---------WSKQSIPLVFFAYIGSDI--LNLKERPMFYK-FFDLNP-RLLLSIIP----
IrlC_Ddis ---------TKKFAIPLIFFAIS-EECLK----------M-FIQISP-NLVKSTLNLHDW
IrlD_Ddis -----------QLRDPYIFFAGS-KQILQ----------Y-LLEIHT-NSLSETIDIRHW
IrlE_Ddis ---------LSTNGVPFTFLTNR-FEIVT----------SIIMSLHDERSISNSVEPVQW
IrlF_Ddis ---------TRSTLIPILIFAFISNISYDMNCNIANVYLN-YLLLNR-ELYKGSIS----
IrlF_C2d_Ddis ---------TRSTLIPILIFAFISNISYDMNCNIANVYLN-YLLLNR-ELYKGSIS----
10577_Tthe ---------VHNPLINTFISSEYDNTQ-----------------------------IQ--
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ----------HY---PLVAFG-DAE-----------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ---------YT----SAVH---LK------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ---------YT----SSLH---LK------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ---------TEE---GSMQ---E-------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap --------------------------RGLTLAPADGPTTDEVTLQV------SG------
IRE1_Hsap --------------------------RGSTLPLLEGPQTDGVTIGD------KG------
ire-1_Dmel --------------------------TAPPIKLLDGPTGDQNSNQE------TD------
IRE2_Mmus --------------------------RGLTLAPMDGPTTDEVTLQV------SG------
IRE1_Mmus --------------------------RGSTLPLLEGPQTDGVTIGD------KG------
ire-1_Cele --------------------------KLLGPPLLEGPAPIALTEME------KE------
IRE1_Scer --------------------------HPFNPGDHESISSNKVYLDQ------TS------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ISVAISGGLYYDKEEIFRKYP-----------LLQ------------------KES----
IrlB_Ddis ------VPLI--FKTFLSCSDIIRNNFEDDLIN---------------------------
IrlB_C2d_Ddis ------VPLI--FKTFLSCSDIIRNNFEDDLIN---------------------------
IrlC_Ddis ISILTE-FALI-NETFLDHYPLLSAWY---------------------------------
IrlD_Ddis IQAIMSAGQYSSETEFFQYYPKIQELS---------------------------------
IrlE_Ddis LRALAP-FVSN-DEMKLIIYKV-RTLY-----N---------------------------
IrlF_Ddis ------ISQFGCIVNYLKCQNEIEKQYSGCLKLLEGLY---NH------KKEKSPNEPYR
IrlF_C2d_Ddis ------ISQFGCIVNYLKCQNEIEKQYSGCLKLLEGLY---NH------KKEKSPNEPYR
10577_Tthe ------I---------------------------GGE------------KGIVSFNEGSN
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin --------------------------EGRKGRLIEGSGGSAQSIHDIIRNQKEA------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque --------------------------LPLNVPLIDGPQPQATSLDH--------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap -------------------------------EREGSPSTAVRY-PSGSV------ALPSQ
IRE1_Hsap -------------------------------ECVITPSTDVKF-DPGLKSKNKLNYLRNY
ire-1_Dmel -------------------------------PRTIYINDV---------------LQEHA
IRE2_Mmus -------------------------------EREGSPSTAVRY-PSGSV------ALPSQ
IRE1_Mmus -------------------------------ECVITPSTDLKF-DPGLKGKSKLNYLRNY
ire-1_Cele -------------------------------EYLPPRRPIIRNIPPSITHKT----SDGE
IRE1_Scer -----------------------NLSW-FALSSQNFPSLVESA-PISRY------ASSDR
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ----------------TLQKYPRPVNILEF-----------------QT------L----
IrlB_Ddis ----------------FEDDDSSSVNFFGFTSNFSNSDQ-DYL-SALET------CFENS
IrlB_C2d_Ddis ----------------FEDDDSSSVNFFGFTSNFSNSDQ-DYL-SALET------CFENS
IrlC_Ddis --------------------------------------S-DAR-SVETS------LFRLF
IrlD_Ddis -------------------------------------LR-DKY-SRTLN------ILELQ
IrlE_Ddis ----------------YEPHSN---------------GE-IKY-TELVR------LFDVQ
IrlF_Ddis IDLLFGVINDRLKAPIFINKDKYESLYFVYQEDYQNPS----------------------
IrlF_C2d_Ddis IDLLFGVINDRLKAPIFINKDKYESLYFVYQEDYQNPS----------------------
10577_Tthe FQLIPLQISTKLKNQCLENKQCRERL----------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin -------------------------------DRRIRCED---------------NP-RDR
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque --------------------------------NL--------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque --------------------------------SH--------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ---------------------------------------------PS-------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ----------------------------------------------------YLD-----
IRE-1_Smoe ----------------------------------------------------YLD-----
IRE2_Hsap WLL---------------------------------------------------------
IRE1_Hsap WLL---------------------------------------------------------
ire-1_Dmel GIM---------------------------------------------------------
IRE2_Mmus WLL---------------------------------------------------------
IRE1_Mmus WLL---------------------------------------------------------
ire-1_Cele YLL---------------------------------------------------------
IRE1_Scer WRV------------------SSIFEDETLFKNAIMGVHQIYNNEYDHLYENY------E
IreA_Ddis -----------------------------------------------------------P
IrlA_Ddis --L----------ENNECIEYIARTF--IKEIP-PHEVPTVKHSDLLILFEIS------V
IrlB_Ddis N-V----------FNDQQLKQMARKL--LTFSK-RENQSRIAESELLEELELE------E
IrlB_C2d_Ddis N-V----------FNDQQLKQMARKL--LTFSK-RENQSRIAESELLEELELE------E
IrlC_Ddis TCM----------DKIDCINYLIQTY--LLPIP-TFKN-TLNNFETCYFFETY------F
IrlD_Ddis YIL----------GHIEGIEFLLEKY--LDFTK-PY---HLDNQELLEIFDVT------F
IrlE_Ddis YLLTKGKFSLSQFNGFETSIFLNPKL--LDGTI---------NSNILNSMIIK------D
IrlF_Ddis ----------------DPFRVLPTRS--VDLSKISEGISRMKNDDFLNELEKE------E
IrlF_C2d_Ddis ----------------DPFRVLPTRS--VDLSKISEGISRMKNDDFLNELEKE------E
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ECL---------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque --------------------------------S-VSNKNRIEFTLLLMKRNVISVGDVSK
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque --------------------------------N-VSNMSRVQFTRLLMERGVIEAGDVSK
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque --F---------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe YL----------------------------------------------------------
IRE-1_Smoe YL----------------------------------------------------------
IRE2_Hsap ------IGHHELPPV---------------------LH-----------T-T--MLR--V
IRE1_Hsap ------IGHHETPLS---------------------AS-----------T-K--MLE--R
ire-1_Dmel ------LGHYNMPNEGN--GNL--------QLSPTTAS-----------S-K--VVQ--S
IRE2_Mmus ------IGYHEPPPV---------------------LH-----------T-T--MLR--V
IRE1_Mmus ------IGHHETPLS---------------------AS-----------T-K--MLE--R
ire-1_Cele ------LGYHDRPMM---------------------TM-----------ATI--IPT--R
IRE1_Scer KTNSLDTTHKYPPLM---------------------ID-----------S-S--VDTTDL
IreA_Ddis KKKK--------------------------------------------------------
IrlA_Ddis MKKR--------------------------------------------------------
IrlB_Ddis KRKK--------------------------------------------------------
IrlB_C2d_Ddis KRKK--------------------------------------------------------
IrlC_Ddis L-----------------------------------------------------------
IrlD_Ddis VQKK--------------------------------------------------------
IrlE_Ddis KEKL--------------------------------------------------------
IrlF_Ddis KQKK--------------------------------------------------------
IrlF_C2d_Ddis KQKK--------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------LGMHPLDETDGHESRMRRLLEGPSSISPIPTFRPGQNQWIDHGIEVVPNIE--A
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque IEDK----------------------------------------------------V--R
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque IEDK----------------------------------------------------D--R
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------SGHYPLPED---------------------SR-----------IK---IEQ--L
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe -----VKNHTLPPVS---------------------AP-----------S-N--AIL--A
IRE-1_Smoe -----VKNHTLPPVS---------------------AP-----------S-N--AIL--A
IRE2_Hsap HPTL-GSGTAE----------T--------------------------------------
IRE1_Hsap FPNN-LPKHRE----------N--------------------------------------
ire-1_Dmel LATI-HNYNDG----------Y--------------------------------------
IRE2_Mmus HPIP-GKVSAE----------T--------------------------------------
IRE1_Mmus FPNN-LPKHRE----------N--------------------------------------
ire-1_Cele YPVP-GPHK------------A--------------------------------------
IRE1_Scer HQNNEMNSLKE----------Y--------------------------------------
IreA_Ddis ----------K--KQKNK------------------------------------------
IrlA_Ddis --------------------SI-RSKE-------------SLQAELDLI--EEEKREKKK
IrlB_Ddis ----------QKQQ-EKIKKRL-KREK-------------RLKEKQDLLLIKLEK-----
IrlB_C2d_Ddis ----------QKQQ-EKIKKRL-KREK-------------RLKEKQDLLLIKLEK-----
IrlC_Ddis ------------------------ENS-------------SIKAEQYLL--EQELL----
IrlD_Ddis -----------------D---I-RTEE-------------SLKAEKDLL--EQEEN----
IrlE_Ddis -----------------DLKELFFKEKPLSEAELKEKFEIATKNEKELL--DQLKKEN--
IrlF_Ddis ----------LKTKQKKKIKKL-ENEK-------------KQK----VL-----------
IrlF_C2d_Ddis ----------LKTKQKKKIKKL-ENEK-------------KQK----VL-----------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin PPNN-SQQPAT----------P--------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque YPIF-F---------KEYKKRTE-------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque YPLF-F---------KKYKKRCK-------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque LSEK-WSQEKY----------R--------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe LPSGSNPRNST-------------------------------------------------
IRE-1_Smoe LPSGSNPRNST-------------------------------------------------
IRE2_Hsap ---------------------------------------RPPEN--TQAPAFFLELLSLS
IRE1_Hsap ---------------------------------------VIPAD--SEKK-SFEEVINLV
ire-1_Dmel ---------------------------------------GLLAN--NEKN-AA-------
IRE2_Mmus ---------------------------------------RASED--LHAPPVFFELLNLR
IRE1_Mmus ---------------------------------------VIPAD--SEKR-SFEEVINIV
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ---------------------------------------MSPED--LEAYR---------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis QKDKKKNKSNQNQKNNNNQNNQSNNNKINSPSSNKLTQNVTPPS--SPVN-IITSSSTTS
IrlB_Ddis QKEK--------------------------------------------------------
IrlB_C2d_Ddis QKEK--------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis QQDK--------------------------------------------------------
IrlF_C2d_Ddis QQDK--------------------------------------------------------
10577_Tthe ---------------------------------------IFSVDKFDDKN-YIRDVMTCI
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ---------------------------------------VPPEE--VR------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap RE---------------KL-----------------WDSELHPEEKTPDSYLGLGP----
IRE1_Hsap DQTSENAPTTVSRDVEEKP-----------------AHAPARPEAP-----VDSML----
ire-1_Dmel DIGVQTDPELVEIGIDQRTNGNTINRTKTII-----LQNSNKVQAF-INEWFMEHP----
IRE2_Mmus RE-----------------------------------DPELHPEEKASDSYPGLGS----
IRE1_Mmus GQTSDNTPTTVSQDVEEKL-----------------ARAPAKPEAP-----VDSML----
ire-1_Cele -------------------IGSTIERPPPQL------LGPVEPQKHEDTSFILLLLN---
IRE1_Scer ---KKI-HEQISRELD----------------------------EKNQNSLL-LKF----
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis SSTSSTTSS----TTSST-----IEPKPPTQTLPIKTSSPTKPESQKPSTPDPLIPKSSK
IrlB_Ddis -----------------------------------------QLEEQMKKRE--KKL----
IrlB_C2d_Ddis -----------------------------------------QLEEQMKKRE--KKL----
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------DA----
IrlF_Ddis -----------------------------------------QQEKEKKQNY--QQP----
IrlF_C2d_Ddis -----------------------------------------QQEKEKKQNY--QQP----
10577_Tthe DNLRKGRMMIEVISDSKD-----I------------QNASN-----IPSQAFNFAK----
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin -----------------------------------------------K------T-G---
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque --------------------------------------NLL-------------------
AqueK164_Aque ------------------------NNTRAVLFGG--------------------------
AqueK165_Aque --------------------------------------GP--------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque -------------------IGPTVQNK-----------EPL---QVVDGGH-IDGPG---
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe --------------------------------------NSGRGSFP-----VGWLF----
IRE-1_Smoe --------------------------------------NSGRGSFP-----VGWLF----
IRE2_Hsap ----------------------------------------QDLLA-ASLTAVL-LGGWI-
IRE1_Hsap ----------------------------------------KDMAT-IILSTFL-LIGWV-
ire-1_Dmel ----------------------------------------SGKVH-QILIVIV-LGMIA-
IRE2_Mmus ----------------------------------------QDLLA-ATFTAIL-LGAWV-
IRE1_Mmus ----------------------------------------KDMAT-IILSTFL-LVGWV-
ire-1_Cele -----------------------------------------NHPI-PFYATLVTMFALL-
IRE1_Scer ----------------------------------------GSLVYRIIETGVF-LLLFL-
IreA_Ddis -----------------------NNKNNNDEDDENEIENYNDNQN------DL-I-DEF-
IrlA_Ddis STTKNNNNNNNNNNNNNNNNNNNNNNNNNKENREMALEVINEMEK-IEIEESL-L-STS-
IrlB_Ddis --------------------------------------------------QKL-E-RKR-
IrlB_C2d_Ddis --------------------------------------------------QKL-E-RKR-
IrlC_Ddis --------------------------------------------------------EKKK
IrlD_Ddis --------------------------------------------------------EKKR
IrlE_Ddis --------------------------------------------------EKL-K-KKNK
IrlF_Ddis --------------------------------------------------QDL-Q-QHN-
IrlF_C2d_Ddis --------------------------------------------------QDL-Q-QHN-
10577_Tthe ----------------------------------------DNKIT-IFLLTFL-IILVI-
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ----------------------------------------WEYLG-VTLGLGL-VSLWF-
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ----------------------------------------PDVLG-FSFSLLLVVAGTV-
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ----------------------------------------GALLACLAVVTLV-LKGVL-
IRE-1_Smoe ----------------------------------------GALLACLAVVTLV-LKGVL-
IRE2_Hsap LFVM--R-----QQ-----------QPQVVE-----------------------------
IRE1_Hsap AFII--TYPLSMHQ-----------QQQLQHQQFQKELEK--------------------
ire-1_Dmel LFWY--T----CST-----------MRELQ------------------------------
IRE2_Mmus LYLM--R-----Q-----------------------------------------------
IRE1_Mmus AFII--TYPLSVHQ-----------QRQLQHQQFQKELEK--------------------
ire-1_Cele L-----TVIWQCGR-----------QWD--------------------------------
IRE1_Scer IFCA-------ILQ-----------RFKILP--------P--------------------
IreA_Ddis --IS--TN---SVI-----------QQQ--------------------------------
IrlA_Ddis SLVQ--PQ---QQS-----------QQSQQQQEQQQQQQQ--------------------
IrlB_Ddis LYKK--LQ---DDE-----------KQKLIEKQKQKEKEK--------------------
IrlB_C2d_Ddis LYKK--LQ---DDE-----------KQKLIEKQKQKEKEK--------------------
IrlC_Ddis QKEK---K---KQK-----------QKQSKS-KI--------------------------
IrlD_Ddis LKEK---R---KKE-----------EKEKKKQQN--------------------------
IrlE_Ddis LKKQ---K---NQQ-----------QQQQAKQQAQQQKQQ--------------------
IrlF_Ddis LKIQ--TQ---QQQ-----------QQQQQQQQQQQQQQQ--------------------
IrlF_C2d_Ddis LKIQ--TQ---QQQ-----------QQQQQQQQQQQQQQQ--------------------
10577_Tthe ILIL--KD-ERITSMYKRNSGRSGGKSSSQKQNSQEEADK--------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin LFK-------KF---------------------GQREGFKVPKFIPVPNGDAQIARPLAP
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque -KE----M---N-------------PQHMVTPEQQQDTHL--------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque --------------------------------------TK--------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque VFSSLVASVVAVLV-----------TKS--------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe HF----------GQ------------KEKQKKEKE-------------------------
IRE-1_Smoe HF----------GQ------------KEKQKKEKE-------------------------
IRE2_Hsap -------------------------K--------------QQETPLAPAD----------
IRE1_Hsap -------------------I-QLL-QQQ------------QQQLPFHPPG----------
ire-1_Dmel -------------------------K--------------QSENGSKT------------
IRE2_Mmus ----------------------------------------QQQSPSAPAG----------
IRE1_Mmus -------------------I-QLL-QQQ--------------QLPFHPHG----------
ire-1_Cele ----------------------------------------QQKSTSRMDS----------
IRE1_Scer -------------------L-YVL------------------------------------
IreA_Ddis -----------------------Q-QQ-------------QQQ-----------------
IrlA_Ddis -------------------Q-QQQ-QQQQQQQ-QQQQQQ-QQQQQQ--------------
IrlB_Ddis -------------------E-LSK-QKEKEFELLKQKEI-DEIKQKSIQE----------
IrlB_C2d_Ddis -------------------E-LSK-QKEKEFELLKQKEI-DEIKQKSIQE----------
IrlC_Ddis ------------------------IN--------------------NPLS----------
IrlD_Ddis ------------------------LKQKSLIT--------------NNTT----TTTTTT
IrlE_Ddis -------------------H-QQNIQQNYENQHIEDQRKFNQQTKGRPIS----------
IrlF_Ddis -------------------Q-QQQ-QQQQQQQQQQQSQQ-QQQQQQSPQQ----------
IrlF_C2d_Ddis -------------------Q-QQQ-QQQQQQQQQQQSQQ-QQQQQQSPQQ----------
10577_Tthe -------------------VLEKI-SKEQEEEIKKQNEQ-N-NKQE--------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin IPDTATEPAPAPEPATVQPL-QII-PEQ--------------PAPPAPLPLPLPP-----
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque -------------------Y-TTT-TE--------------LSEST--------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ----------------------VT-AP--------------ATDET--------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ----------------------------------------TQNVPHN-------------
AqueK169_Aque -------------------------------------------AVA--------------
IRE-2_Smoe -------------------------QQQ------------KRKKRRGPK-----------
IRE-1_Smoe -------------------------QQQ------------KRKKRRGPK-----------
IRE2_Hsap ------FA---HISQD-------------------AQSLH--------------------
IRE1_Hsap -----------DTAQD-------------------GELLDTS------------------
ire-1_Dmel ------FA----------------------------------------------------
IRE2_Mmus ------PP---DLSQD-------------------AQGQL--------------------
IRE1_Mmus -----------DLTQD-------------------PEFLDSS------------------
ire-1_Cele ------FE----------------------------------------------------
IRE1_Scer ------------LSKI-------------------GFMPEKE------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------IDEINKNIQQ-------------------NQLKIDEINKKLEIKEIQNFQLPLL
IrlB_C2d_Ddis ------IDEINKNIQQ-------------------NQLKIDEINKKLEIKEIQNFQLPLL
IrlC_Ddis ------SSS--SSS----------------------SSPSTS-----------------N
IrlD_Ddis PIPITVPIP--TQT----------------------QTPTQT-----------------P
IrlE_Ddis ------PSS--IQNQN--------------------LNPTLL-----------------Q
IrlF_Ddis ------QSQ--QQSQQ-------------------SQQKSQQQS---------------Q
IrlF_C2d_Ddis ------QSQ--QQSQQ-------------------SQQKSQQQS---------------Q
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------LE---DPTTDALAGTGEEGDDTDREGDPEPE-----------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------PS----------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis NQQ-------------QQQPPPLQLLKQQQQQPS-----------SS---------LTIQ
IrlB_C2d_Ddis NQQ-------------QQQPPPLQLLKQQQQQPS-----------SS---------LTIQ
IrlC_Ddis TT----------------------------------------------------------
IrlD_Ddis TQTPIPTPIPTTPIPTTPIPIPIQLTPTTPKTPK-----------TPKTPKTPTTPK---
IrlE_Ddis NQ----------------------------------------------------------
IrlF_Ddis QKS-------------QQQSPPQQQ-QQQSQQPQQQSQQQSQQKQK--------------
IrlF_C2d_Ddis QKS-------------QQQSPPQQQ-QQQSQQPQQQSQQQSQQKQK--------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------AETKDD------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ----GPYSE---------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ----GPFSE---------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ----IPIVE---------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis LESITPIL----------------------EPKNDNVVLLKSSIETPIDSVKKIQSIIEI
IrlB_C2d_Ddis LESITPIL----------------------EPKNDNVVLLKSSIETPIDSVKKIQSIIEI
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ----TPITPKTPKNSTLDKQTISTPKTPPPL-----------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis -----------------------------------------------------HQKQQQQ
IrlF_C2d_Ddis -----------------------------------------------------HQKQQQQ
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ----DTASE---------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ----VPVQE---------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ---------------------------------------------------S--SGTSSP
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ---------------------------------------------------S--SGTSSP
ire-1_Cele -----------------------------------------------------------I
IRE1_Scer ---------------------------------------------------S--KSLNCP
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis QLEEENQKKKEMETIDEYEEININKKQINSNMKWGGIGEPSWISVKKDNKKSK-------
IrlB_C2d_Ddis QLEEENQKKKEMETIDEYEEININKKQINSNMKWGGIGEPSWISVKKDNKKSK-------
IrlC_Ddis ------------------------------------------------------ITSTTP
IrlD_Ddis -------------------------------------------------SVNTTPITPSP
IrlE_Ddis ------------------------------------------------------NQTSNP
IrlF_Ddis QKQEKQQQKQE--KQQQKQ-----------------------------------------
IrlF_C2d_Ddis QKQEKQQQKQE--KQQQKQ-----------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin -----------------------------------------------------------T
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ---------------------------------------------------C--TEDSQS
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ---------------------------------------------------R--KAQATS
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque -----------------------------------------------------------P
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ----------------------------------SG----------------AS-RRSQK
IRE1_Hsap STS--------PR----------------ASNH-SL----------------CS-GSSAS
ire-1_Dmel -IA--------QN----------------GSN-----------------------GSTGS
IRE2_Mmus ----------------------------------SR----------------DI-LQDQR
IRE1_Mmus SPS--------PR----------------ASNH-SL----------------HP-SSSAS
ire-1_Cele VNN--------PG----------------ESRS--A----------------QT-SK-QS
IRE1_Scer SSSENVT---KPFDMKSGKQVVFEGAVNDGSLK-SEKDNDDADEDDEKSLDLTTEKKKRK
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis -------------------------------EKQ---Q----------------------
IrlB_Ddis ---STITTSTTPT---T-------------TTPA---KVITSQFKNEQ------------
IrlB_C2d_Ddis ---STITTSTTPT---T-------------TTPA---KVITSQFKNEQ------------
IrlC_Ddis TTTTTTTTTTTPT---T-------------TTTT---TTT-SSP-KQKP-----------
IrlD_Ddis PPQTIATT-ITTT---T-------------TTPK---TTK-TTT-TSK------------
IrlE_Ddis TPNLESTKKATPT---T-------------TTTT---TTN-S-N-TSAI-----------
IrlF_Ddis ------------------------------EKPQ---Q--KQQL-ENQ------------
IrlF_C2d_Ddis ------------------------------EKPQ---Q--KQQL-ENQ------------
10577_Tthe -------------------------------K----------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin VAT--------PG----------------RKKPRRG----------------KR-GKKKK
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque -------------------------------------------------------HNLTS
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque IEQ--------PS----------------ITV---S----------------H--RTMTA
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque SQS--------PS----------------TST---V----------------S--HPTTA
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque IPT--------PD----------------SSKT-GS----------------HT-SKTHS
AqueK169_Aque -------------------------------------------------------DGIDG
IRE-2_Smoe -----------------------------GDRA--S-------------------QENVS
IRE-1_Smoe -----------------------------GDRA--S-------------------QENVS
IRE2_Hsap RL--Q------------------------SPSK-QA------------------------
IRE1_Hsap KA---------------------------GSSP-SL------------------------
ire-1_Dmel N----------------------------GSNA-NA------------------------
IRE2_Mmus RF--Q------------------------SPSE-PA------------------------
IRE1_Mmus RA---------------------------GTSP-SL------------------------
ire-1_Cele NR---------------------------GSFG-WA------------------------
IRE1_Scer RG--SR-----------------------GGKKGRK------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis --TKKLII-ENNKKQNLINDNNNNNNNNNN------------------------------
IrlB_C2d_Ddis --TKKLII-ENNKKQNLINDNNNNNNNNNN------------------------------
IrlC_Ddis --ITPIKK-EIEKEFEKIELTTPP------------------------------------
IrlD_Ddis --I---------------------------------------------------------
IrlE_Ddis --INEIKNQDLN------------------------------------------------
IrlF_Ddis --IKNLKI-EIKKEEENNKEIKNKKEEVEK------------------------------
IrlF_C2d_Ddis --IKNLKI-EIKKEEENNKEIKNKKEEVEK------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin KDATPIPG-EEGVEGKAPNGPDGPAA---NGTP-NI------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque EK-----------------------------AK-DD------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque AA---------------------------T-SL-ETTQSSGTTVSSYCSSSTDSDPLDAA
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque SA---------------------------T-SP-EA------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque QT---------------------------TDNS-KG------------------------
AqueK169_Aque EM---------------------------QDLK-ST------------------------
IRE-2_Smoe KQ---------------------------VDDA-KV------------------------
IRE-1_Smoe KQ---------------------------VDDT-KV------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque PVMMKVVKFLKPFESQWHLIGVSLELKVDKLVMIDYRNNSSCLATVLNAWKSSPGSVPYT
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap -----------QPLD------------------DPEAEQLTVV-GKISFN--PKDVLGRG
IRE1_Hsap -----------EQDD------------------GDEETSVVIV-GKISFC--PKDVLGHG
ire-1_Dmel -----------EDL-------------------VDLGNGQVRV-GKISFS--TNEVLGKG
IRE2_Mmus -----------QPPH------------------DPEAGQPTVV-GKISFN--PKDVLGRG
IRE1_Mmus -----------EQDD------------------EDEETRMVIV-GKISFC--PKDVLGHG
ire-1_Cele -----------NRK-------------------IEIPEGWMAVGSKLMYS--PSDILGTG
IRE1_Scer -----------SRI-------------------ANIPNFEQSL-K-NLVV--SEKILGYG
IreA_Ddis ------------LINSSNKI-----N-NGSGK-IILDNGNVKI-GKLEII--TNKILGTG
IrlA_Ddis -----------EQQEQQESIQ----LNQTLTP-I--I-PDFQI-GKFKFSRDENNIIGRG
IrlB_Ddis -----------NNNNNNNNN-----NNNKLNN-IIQDEDFVSI-GKFKFNRNESNILGRG
IrlB_C2d_Ddis -----------NNNNNNNNN-----NNNKLNN-IIQDEDFVSI-GKFKFNRNESNILGRG
IrlC_Ddis -----------------PPL-----A-TTKQQ-QINENYDISI-GKFKFNRKEENVLGRG
IrlD_Ddis ----------------------------PTLI-IELNKYDISI-GKFKFSRKDEFIIGRG
IrlE_Ddis -------------------Q-----Q-QNITE-NINEIYDVSI-GKFKFNKKESNILGRG
IrlF_Ddis -----------EKEENNKEI-----KSKSEFI-IVEDEDFVSI-GKFKFNRNESNILGRG
IrlF_C2d_Ddis -----------EKEENNKEI-----KSKSEFI-IVEDEDFVSI-GKFKFNRNESNILGRG
10577_Tthe -----------KNQE-------------------SSEQNANKF-KGLQIN--RNKVLGYG
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin -----------NPPDNNPDATIAPAAPQSPSLVVSSPIIPAAA-GPSLVV--SDTILGFG
AqueK159_Aque ------------------------------------------N-RELEVEAEGS------
AqueK160_Aque -----------AAER------------------QPDRHAIKII-GDI--SYICTEKLGDG
AqueK161_Aque ----------------------------------------------------KNSLLGKG
AqueK162_Aque --------------------------------------LVSIN-ESLSFQYDKKSLLGTG
AqueK163_Aque WRSVIEVLEALGDDG------------------NPESSLASIN-ESLSFQYDKKSLLGKG
AqueK164_Aque ------------------------------------DQ-DNFT-N---------------
AqueK165_Aque -----------TQPS------------------DPESSLVLIN-ESLSFQFDKKLLLGKG
AqueK166_Aque --------------------------------------GLIVN-KSLWYDVCEDSLLGKG
AqueK167_Aque -------------------------------------RIKEVN-P--NFSYDVSIKLGQG
AqueK168_Aque -----------GGA-------------------IEATD-----G-ERGSN--RSSIALSD
AqueK169_Aque -----------EHHF------------------NPGAANEVKI-GAI--TYFRNEKLGDG
IRE-2_Smoe -----------DQPK--------------------KQDADGRI-GSLTI---SKIVIGYG
IRE-1_Smoe -----------DQPK--------------------KQDADGRI-GSLTI---SKIVIGYG
IRE2_Hsap AGGTFVFRGQFEGR--------------------AVAVKRLLRECFGLVRREVQLLQE--
IRE1_Hsap AEGTIVYRGMFDNR--------------------DVAVKRILPECFSFADREVQLLRE--
ire-1_Dmel CEGTFVFKGTFEER--------------------FVAVKRLLPECFTFADREVALLRE--
IRE2_Mmus AGGTFVFRGQFEGR--------------------AVAVKRLLRECFGLVRREVQLLQE--
IRE1_Mmus AEGTIVYKGMFDNR--------------------DVAVKRILPECFSFADREVQLLRE--
ire-1_Cele CEGTVVYRGTFDGR--------------------EVAVKRVVSEFVKFAHREADLLRE--
IRE1_Scer SSGTVVFQGSFQGR--------------------PVAVKRMLIDFCDIALMEIKLLTE--
IreA_Ddis SCGTIVYEGKMEGR--------------------KVAVKRMLSQFVKFADREVSILIH--
IrlA_Ddis SNGTLVFRGIWNDR-------------------IPVAVKQMQKAFNPHISKEIEVLIRLT
IrlB_Ddis SNGTLVFKGLWSDK-------------------IPVAIKQMQKAFNPLINKEVEALISLT
IrlB_C2d_Ddis SNGTLVFKGLWSDK-------------------IPVAIKQMQKAFNPLINKEVEALISLT
IrlC_Ddis SNGTLVFKGIWNNR-------------------IPVAIKQMQKMFNPLISKEIEVLITLT
IrlD_Ddis SNGTLVFKGIWNDR-------------------IPVAIKQMHKAFNPLISKEIEVLITLT
IrlE_Ddis SNGTLVFKGIWNNR-------------------IPVAIKQMQKMFNPLISKEIEILIGLT
IrlF_Ddis SNGTLVFKGIWSDK-------------------IPVAIKQMQKAFNPLINKEVEALITLT
IrlF_C2d_Ddis SNGTLVFKGIWSDK-------------------IPVAIKQMQKAFNPLINKEVEALITLT
10577_Tthe AQGTVIFEGTFQGNIQEQKIVFDLINIVYVNIGREIAVKQLLKDNKDLASKEIQMLIKL-
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin SHGTVVFQGSLQGR--------------------AVAVKRLLKDFVTLASREVSILQE--
AqueK159_Aque ------------------------------------------------------SL-L--
AqueK160_Aque SKGTTVYKGQFSEH--------------------DVAVKVGKKDV--ITGTEIKMLMQ--
AqueK161_Aque ASST-VYKGTFKRE--------------------GVAVKRMKEE---LSDDDKKFL-L--
AqueK162_Aque ASST-VYKGTFKEE--------------------DVAVKRMKEE---LSDEYKELL-L--
AqueK163_Aque ASST-VHKGTFKEE--------------------AVAVKRMKEE---LSDEYKDLL-K--
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ASST-VHKGTFKEE--------------------DVAVKRMKEE---LSDEYKELL-L--
AqueK166_Aque KSST-VRRGTYNGQ--------------------EVAVKRLYEKT--LSSEDINLL-L--
AqueK167_Aque ASSI-VHKGTYEGQ--------------------EVAVKKMKDK---LTDDAKLLL-L--
AqueK168_Aque STQSIYRNGSFDSR--------------------PVAVKRVIQNYFDLADREVALLRE--
AqueK169_Aque ASGTTVYKGQFSGK--------------------DVAVKVGKKTA--IRDLEKKIL-E--
IRE-2_Smoe SHGTRILEGKLDQR--------------------QVAVKSILSGFYHKASKEIAALIE--
IRE-1_Smoe SHGTRILEGKLDQR--------------------QVAVKSILSGFYHKASKEIAALIE--
IRE2_Hsap SDRHPNVLRYFCTERG--PQFHYIALELCRASLQEYVEN----------------PDLD-
IRE1_Hsap SDEHPNVIRYFCTEKD--RQFQYIAIELCAATLQEYVEQ----------------KDFA-
ire-1_Dmel SDAHENVVRYFCTEQD--RQFRYIAVELCAATLQDYTEG----------------DRSL-
IRE2_Mmus SDRHPNVLRYFCTEHG--PQFHYIALELCQASLQEYVES----------------PDLD-
IRE1_Mmus SDEHPNVIRYFCTEKD--RQFQYIAIELCAATLQEYVEQ----------------KDFA-
ire-1_Cele SDTHPHVIRYFCMESD--SQFRYLALELCIASLNDYVEQ----------------KEVQ-
IRE1_Scer SDDHPNVIRYYCSETT--DRFLYIALELCNLNLQDLVES----------------KNVS-
IreA_Ddis SDEHTNVVRYYAKEED--DEFIYLAISFCQKSLDMYVQQ----------------TLSL-
IrlA_Ddis SNNCSNMIRYIDQEED--QLFVYLGLTLCEESLQDLMES----------------KRYK-
IrlB_Ddis SKNCSNMIRYIDKEED--KLHVYLGLTLCDGSLQNLVES----------------GKLN-
IrlB_C2d_Ddis SKNCSNMIRYIDKEED--KLHVYLGLTLCDGSLQNLVES----------------GKLN-
IrlC_Ddis NKNCYNIVRYIDQEED--ESCVYLGLTLCDGSLQNLVEK----------------GDNNL
IrlD_Ddis NKNCNNIVRYIDQEED--DMFVYLGLTLCNGSLQNLVEK----------------DLEIN
IrlE_Ddis NK-NLNLVGYIDQEED--ENCVYLGLTLCDGSLQSLYDQ----------------SKLN-
IrlF_Ddis NKNCSNMIRYIDKEED--KHFVYLGLTLCDVSLQYLVEN----------------GKLN-
IrlF_C2d_Ddis NKNCSNMIRYIDKEED--KHFVYLGLTLCDVSLQYLVEN----------------GKLN-
10577_Tthe --QHKNIIKYYYFEET--KDHILLGLEKCVGSISDLIDY----------------ANRK-
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin SDDHPNVIRYYYQEAH--ANFLYIALELCPASLADIIET----------------PDRE-
AqueK159_Aque HISHTSPCP---------------------------------------------------
AqueK160_Aque FRKHENIVEYYHSESD--VEYYYLAFQLCLTSLENFIKN----------------EEKR-
AqueK161_Aque SIKHDNIVLVHCIY----------------------FKK----------------LKKV-
AqueK162_Aque NIKHENIVLVLCIY----------------------FKE----------------FKEV-
AqueK163_Aque NIKHENIVLVLCIY----------------------FKE----------------FEKV-
AqueK164_Aque ---------------------NIYILEISIST----------------------------
AqueK165_Aque NIKHKNIVLVLCIESY--QGLDHIVLELCLASFHQYFKE----------------FEKV-
AqueK166_Aque TIQHENIVKILAIEDG--LENQYIVLELCLASLDLFCVN----------------YKKV-
AqueK167_Aque DIKHENIVQLLNIETDEHNEHDYIILELCLASLSKYFKH----------------YETV-
AqueK168_Aque SDQHPNVIRYFCMEED--PTFRYLALELCSATLHEYVEG----------------QKMS-
AqueK169_Aque RCRHENIVEYYHFDSD--IEYNYLAFQLCDISLENFIEN----------------EDKR-
IRE-2_Smoe LDTHPNVVRYYSMEQD--NDFVYIALERCSFNLETFILVHAAGADNRTEVNEFEEKELQ-
IRE-1_Smoe LDTHPNVVRYYSMEQD--NDFVYIALERCSFNLETFIVVHAAGADNRTEVNEFEEKELQ-
IRE2_Hsap ----------------R----------------------------------GGLEPEVVL
IRE1_Hsap ----------------H----------------------------------LGLEPITLL
ire-1_Dmel ----------------EL--------------------------------QNHIDVWQVL
IRE2_Mmus ----------------R----------------------------------WGLEPTTVL
IRE1_Mmus ----------------H----------------------------------LGLEPITLL
ire-1_Cele ----------------QN---------------------------------VTIALRDIM
IRE1_Scer ----------------DENL------------------------KL----QKEYNPISLL
IreA_Ddis ----------------QISPTDSPSIQSSNNNGNGNNGNNNNNNQI----IIDNKTKQMI
IrlA_Ddis ----------------EFIEKTT-----------TTNITTTFNNNIIDENLYEQRILSLF
IrlB_Ddis ----------------DFVISS------------------------------NKSIIELA
IrlB_C2d_Ddis ----------------DFVISS------------------------------NKSIIELA
IrlC_Ddis -------------TLTQFLGYDI------------N------SS-----SKNNSRLLELI
IrlD_Ddis LISTSNNENNNNNKLKNFI-------------------------------GSELRLLELI
IrlE_Ddis ----------------EFINQNN-----------NQ------NN-----NNNNNRVLDLI
IrlF_Ddis ----------------EFINSS------------------------------GKSLNELA
IrlF_C2d_Ddis ----------------EFINSS------------------------------GKSLNELA
10577_Tthe ----------------NKKKSEQ-DLK---------ALYNIKTD-F----FIKSTMKNTF
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ----------------AFR-------------------------DI----AISFDPKRAL
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ----------------EAILR-----------------------------DFVVSKKEIL
AqueK161_Aque ----------------MDKFD-----------------------------GLTVVKKNVN
AqueK162_Aque ----------------MNKFN-----------------------------GLTVVKKDVN
AqueK163_Aque ----------------TNKFD-----------------------------GLTVVKKDVN
AqueK164_Aque ----------------------------------------------------------VF
AqueK165_Aque ----------------MNKFN-----------------------------GLTVVKKDVN
AqueK166_Aque ----------------ANRFS-----------------------------GFIVVKENII
AqueK167_Aque ----------------SSQFV-----------------------------GLNVVIREIL
AqueK168_Aque ----------------E----------------------------------FSIDEKHII
AqueK169_Aque ----------------KDLIR-----------------------------DFYVNKKEIL
IRE-2_Smoe ----------------EILQQKL-----------TL-----WDRSC----LPSPLLMRLM
IRE-1_Smoe ----------------EILQQKL-----------TL-----WDRSC----LPSPLLMRLM
IRE2_Hsap QQLMSGLAH-LHS-LHIVHRDLKPGNILITGPDSQG------------------------
IRE1_Hsap QQTTSGLAH-LHS-LNIVHRDLKPHNILISMPNAHG------------------------
ire-1_Dmel SQAASGLSH-LHS-LDIVHRDIKPQNVLISLPDAKG------------------------
IRE2_Mmus QQMMSGLAH-LHS-LHIVHRDLKPANILMAGPDSQG------------------------
IRE1_Mmus HQTTSGLAH-LHS-LNIVHRDLKPHNILLSMPNAHG------------------------
ire-1_Cele KQATDGLAH-LHA-SKIVHRDMKPQNVLITMASQRG------------------------
IRE1_Scer RQIASGVAH-LHS-LKIIHRDLKPQNILVSTSSRFTA----------------DQQTGAE
IreA_Ddis LELFKGLEH-LHS-LNIVHRDIKPHNVLIDP-----------------------------
IrlA_Ddis KDVINGINF-LHC-QDIVHNDLNPRNILVHK-----------------------------
IrlB_Ddis KDILFGIQF-LHS-HDIVHNDLNPRNILTLIGKTSN-------------------NNNSS
IrlB_C2d_Ddis KDILFGIQF-LHS-HDIVHNDLNPRNILTLIGKTSN-------------------NNNSS
IrlC_Ddis KDIVYGIQF-LHQ-QGIVHNDLNPRNILIK------------------------------
IrlD_Ddis KDIVYGIQF-LHQ-QGIVHNDLNPRNILIK------------------------------
IrlE_Ddis IGMINGVIF-LHD-QNIVHNDLNPRNILVK------------------------------
IrlF_Ddis KDIINGVQF-LHS-HDIVHNDLNPRNILTLSTNKNNNNNNKSNNKIKSNNNSNNNSNNNS
IrlF_C2d_Ddis KDIINGVQF-LHS-HDIVHNDLNPRNILTLSTNKNNNNNNKSNNKIKSNNNSNNNSNNNS
10577_Tthe KDCLEGLSY-LHS-QGVIHRDIKPENILIHY-----------------------------
IRE1_Spur ----------------SVHRDIKPHNVLISQPNQHG------------------------
CC1G_06931_Ccin KQITSGLKH-LHA-LKLVHRDIKPQNILITTNKSTG--------------------RGRP
AqueK159_Aque CAKIMATSYPSSS-TRTIHRDIKPGNILLVQKSS------------------------SS
AqueK160_Aque HGAIRGLNH-LHNEHNIVHRDVKPSNILIVQRNSG-----------------------SM
AqueK161_Aque QDAVKGLEY-LHE-QNIVHRDIKPGNILLVQKSS------------------------SS
AqueK162_Aque QDAVRGLEY-LHE-QNIVHRDIKPGNILLVQKSP------------------------LS
AqueK163_Aque QDAVRGLEY-LHE-QSIVHRDIKPGNILLVQKSS------------------------SS
AqueK164_Aque WQCIKKPEA-I-D-QWPVGRNRHAGAIIITG--SDCPML---------------------
AqueK165_Aque QDAVRGLEY-LHE-QNIVHRDIKPGNILLVQKSS------------------------SS
AqueK166_Aque RDAVKGLEY-LHK-RWIVHRDIKPGNILLLQKGS------------------------SS
AqueK167_Aque QDAVKGMEY-LHK-RNVVHRDLKPGNILLVQKSSS-----------------------SA
AqueK168_Aque AESMSGINH-LHS-LGIVHRDLKPQNVLLRTS-SSL------------------------
AqueK169_Aque FDSIKGLSY-LHK-ENIVHRDVKPSNILLVRRNSS-----------------------SM
IRE-2_Smoe RDVLEGLVH-LHK-LGYVHRDLKPQNVLILRSGT--------------------------
IRE-1_Smoe RDVLEGLVH-LHK-LGYVHRDLKPQNVLILRSGT--------------------------
: .: :. ::
IRE2_Hsap LGRVVLSDFGLCKKLPAGRCSFSL--HSG-IPGTEGWMAPELLQL-LPP-----------
IRE1_Hsap KIKAMISDFGLCKKLAVGRHSFSR--RSG-VPGTEGWIAPEMLSE-DCK-----------
ire-1_Dmel KVRVMISDFGLCKKLNFGKTSFSR--RSG-VTGTDGWIAPEMMRS-QRTVRHDFYYYPTL
IRE2_Mmus QGRVVISDFGLCKKLPVGRCSFSL--HSG-IPGTEGWMAPELLQL-P-P-----------
IRE1_Mmus RIKAMISDFGLCKKLAVGRHSFSR--RSG-VPGTEGWIAPEMLSE-DCK-----------
ire-1_Cele EMRAVISDFGLCKRVQPGKNSISRGIASG-LAGTDGWIAPEVLIS-A-------------
IRE1_Scer NLRILISDFGLCKKLDSGQSSFRTNL-NN-PSGTSGWRAPELLEE-SNNLQCQVE-----
IreA_Ddis NNRVKISDMGLGKLLDNDDQSLTF--T----SDSHGWQPAEYLNG-T-------------
IrlA_Ddis -GNFVISDLGLSKMQVETSYSFTN--N-A-PTGQEGYHPIEVLQE---------------
IrlB_Ddis NNSFIISDLGLSKMEVESSYSFTS--N-I-PTGQGGYHPFEVLQS---------------
IrlB_C2d_Ddis NNSFIISDLGLSKMEVESSYSFTS--N-I-PTGQGGYHPFEVLQS---------------
IrlC_Ddis DDRFIISDLGLSKMEVTSSYSFTM--H-A-PTGQEGFHPAEVLLE---------------
IrlD_Ddis DDRFIISDLGLSKMEVTSSYSFTM--H-A-PTGQEGFHPAEVLLE---------------
IrlE_Ddis DNRLIISDLGLSKMNVSSTYNFST--NAI-PTGQDGYHPVEVLLE---------------
IrlF_Ddis NNSFIISDLGLSKMEVESSYSFTT--N-V-PTGQGGYHPVEVLQS---------------
IrlF_C2d_Ddis NNSFIISDLGLSKMEVESSYSFTT--N-V-PTGQGGYHPVEVLQS---------------
10577_Tthe NKEIKLADFGLSKNISKTNVIFTN--D----IGTWGWRPLEQIDN---------------
IRE1_Spur KVKAMISDFGLCKKLSAGRMSFSR--RSG-VAGTDGWIAPEMLTG-Q-------------
CC1G_06931_Ccin TYRMLISDFGLCKKLDVDQTSFLPTMNGGMGAGTVGWRAPEILRG-EVKLDDL-------
AqueK159_Aque EVKAVLADFGISTELNEREAV-TR--Q-R-GRRTDTWMAPELLLD-DLT-----------
AqueK160_Aque QIKAVISDFGIATELEPDRYSQTT--I-G-LKGTLMWLAPELVNK-TV------------
AqueK161_Aque EVKAVLADFGISTKLNNRDAV-TT--Q-R-RRGTDTWMGPELLLD-DIK-----------
AqueK162_Aque EVKAVLADFDLSAKLDDDRSSKTT--L-N-KRGTLSWMAPELLVE-DGL-----------
AqueK163_Aque EVKAVLADFGLSTKLDDDQFSKTT--V-D-GRGTKAYIPPELLVE-DGS-----------
AqueK164_Aque ---VISGGFDKNIDTLDDCWIFN--------ITQHSWIKLDVPHSVS-------------
AqueK165_Aque EVKAVLADFDLSTKLDDDRSLKTT--L-N-KRGTLSWMAPELLVK-DGL-----------
AqueK166_Aque EVKAVLADFGISTKLTSRDSK-TT--H-R-GRVTDTWMAPELLLD-DPS-----------
AqueK167_Aque DVKAVLADFGISVTLIDDLNSLTT--R-T-ARGTDTWKAPELLLD-NRK-----------
AqueK168_Aque KVRALISDFGLCRKLPDGRGSFTA--QSG-ILGTEGWIAPEMFQD-R-------------
AqueK169_Aque KIKAVISDFGIAAELDPGRISKTT--T-G-LKGTLLWVAPELLNK-RRDP----------
IRE-2_Smoe FLSAKISDMGISKRLNDGASGIDK--LTT-GMGSSGWQAPEQIQG-E-------------
IRE-1_Smoe FLSAKISDMGISKRLNDGASGIDK--LTT-GMGSSGWQAPEQIQG-E-------------
..:. : :
IRE2_Hsap ------------------------------------------------------DSPT--
IRE1_Hsap ------------------------------------------------------ENPT--
ire-1_Dmel LLHHHKNFLK---------------------------------------SMSFNYLQT--
IRE2_Mmus ------------------------------------------------------DSPT--
IRE1_Mmus ------------------------------------------------------DNPT--
ire-1_Cele -------------------------------------------------------STS--
IRE1_Scer ----------TEHSSSRHTVVSSDS---------------------FYDP-FTKRRLT--
IreA_Ddis ------------------------------------------------------NRNT--
IrlA_Ddis ------------------------------------------------------KRKT--
IrlB_Ddis ------------------------------------------------------KRMT--
IrlB_C2d_Ddis ------------------------------------------------------KRMT--
IrlC_Ddis ------------------------------------------------------KRKT--
IrlD_Ddis ------------------------------------------------------KRKT--
IrlE_Ddis ------------------------------------------------------KRKT--
IrlF_Ddis ------------------------------------------------------KRMT--
IrlF_C2d_Ddis ------------------------------------------------------KRMT--
10577_Tthe ------------------------------------------------------QPLT--
IRE1_Spur ------------------------------------------------------DRTT--
CC1G_06931_Ccin ---------SD------------DHSMSSRGSVSTINGSSSSSSTSGLST-AKPTRLT--
AqueK159_Aque -----------------------------------------------------DCKFS--
AqueK160_Aque ------------------------------------------------------KKFS--
AqueK161_Aque -----------------------------------------------------ACKFS--
AqueK162_Aque -----------------------------------------------------ELQFS--
AqueK163_Aque -----------------------------------------------------KLKFS--
AqueK164_Aque ------------------------------------------------------KRRSHS
AqueK165_Aque -----------------------------------------------------ELQFS--
AqueK166_Aque -----------------------------------------------------GCKFS--
AqueK167_Aque -----------------------------------------------------QRKCG--
AqueK168_Aque ------------------------------------------------------TRVT--
AqueK169_Aque -----------------------------------------------------RLKYS--
IRE-2_Smoe -------------------------------------------------------RQT--
IRE-1_Smoe -------------------------------------------------------RQT--
IRE2_Hsap SAVDIFSAGCVFYYVLSGGSHPFGD-SLYRQA----NILTG-APCLAH-LEEEV----HD
IRE1_Hsap YTVDIFSAGCVFYYVISEGSHPFGK-SLQRQA----NILLG-ACSLDC-LHPEK----HE
ire-1_Dmel TAVDIFSLGCVYYYVLSGGHHAFGD-NLKRQA----NILSH-EYNLAK-LRPEDDSEDSR
IRE2_Mmus SAVDIFSAGCVFYYVLSGGSHPFGE-SLYRQA----NILSG-DPCLAQ-LQEET----HD
IRE1_Mmus YTVDIFSAGCVFYYVISEGNHPFGK-SLQRQA----NILLG-ACNLDC-FHSDK----HE
ire-1_Cele YPVDIFSLGCIFYYVLTSGTHPFGK-SLHRQA----NIVNG-EYTLNK-LAD-L----DD
IRE1_Scer RSIDIFSMGCVFYYILSKGKHPFGD-KYSRES----NIIRG-IFSLDE-MKCLHDR--SL
IreA_Ddis KKVDIFSLGCVVYYLLT-GAHPFGH-RYNREK----NVLKG-KFDIDQ-IK--------H
IrlA_Ddis KSVDIFSLGCILFYLLTNGQHPFGNNKLLRVA----NIVYD-KPDLEP-LK--------F
IrlB_Ddis KSVDIFSLGCILFYLLTNGQHPFGNDKLFRIV----NIISN-KMNLTP-LN--------S
IrlB_C2d_Ddis KSVDIFSLGCILFYLLTNGQHPFGNDKLFRIV----NIISN-KMNLTP-LN--------S
IrlC_Ddis KSVDIFSMGCILFYLMTGGQHPFGD-KFYRIV----NILTD-KPILEP-LK--------H
IrlD_Ddis KSVDIFSMGCILFYLMTGGQHPFGD-KFFRMA----NILTD-KPILEP-LK--------H
IrlE_Ddis KSVDVFSLGCLIYFIMTNGAHPFGD-KFSRLR----YITKS-KYNLSQ-LS-------NL
IrlF_Ddis KSVDIFSLGCILFYLFTNGQHPFGNDKLFRIY----NIMLN-KVNLEL-LG--------H
IrlF_C2d_Ddis KSVDIFSLGCILFYLFTNGQHPFGNDKLFRIY----NIMLN-KVNLEL-LG--------H
10577_Tthe YNTDVFSLGCVFYYIYTQGGHPFGE-YLRM-----------------------------E
IRE1_Spur TAIDIFSLGCVFYYVLSNGKHPFGD-SLHRQA----NIISG-EYSLDL-LP-------PD
CC1G_06931_Ccin KSVDIFALGCLYYYTLTNGSHPYGD-RFEREV----NILKD-AKSLDL-LERFG----EE
AqueK159_Aque RESDIFSMGCIIYYVLTKGRHPFNK-GHDNDYTVHQNIKNYMICDFQ-----LL----ND
AqueK160_Aque KAVDIFSMGCVMYYVLSDGHHPFGN-DIV---AIIQNFGTH-SYTLDD-ISDEV----KD
AqueK161_Aque RESDIFSMGCVIYFVETGGSHPFDK-GHDDDYTIHQNVKNYDRCDFR-----LL----HG
AqueK162_Aque LQSDIFSMGCVIYFAETDGNHPFDT-GDSRGAAIHLNVKNYNPCDFH-----LL----NG
AqueK163_Aque PQSDIFSMGCVIYFAETDGHHPFDT-GDSRGAAIHQNVKDYNPCDFR-----LL----DG
AqueK164_Aque LSVFIMSPHCV--WIITAGGAVMTET-LVTNP----NIVML-TELVTDSKG--------E
AqueK165_Aque LQSDIFSMGCVIYFAETDGNHPFDT-GDSRGAAIHQNVKNYNPCDFH-----PL----NG
AqueK166_Aque RQSDIFSMGCVTYYLITKGHHPFNR-GHDNVFRIHQNVKNYVTCDFQ-----LL----ND
AqueK167_Aque RESDIFAMGCVIYFAETGGNHPFDT-GDNA--DIDQNVKMYKKCDFS-----LL----DD
AqueK168_Aque CAVDIFAMGCVIYYVLSCGGHPFGP-PLKRQA----NIEAG-DFSLKA-LIG------ED
AqueK169_Aque KAVDVFSMGCVMYYVLSDGRHPFGE-DII---TIVQNFGTH-SYRLDG-ISGKV----ED
IRE-2_Smoe RAVDMFSVGCLLYFCITGGQHPFGG-RLERDM----NIVSG-KMDLFA-V--------DH
IRE-1_Smoe RAVDMFSVGCLLYFCVTGGQHPFGG-RLERDM----NIVSG-KMDLFA-V--------DH
::: *: : : *
IRE2_Hsap KVVARDLVGAMLSPLPQPRPSAPQVLAHPFFWSRAKQL-QF-------FQD-VSDWLEKE
IRE1_Hsap DVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQL-QF-------FQD-VSDRIEKE
ire-1_Dmel IILAEQLISDMIHKDPQSRPPARCIGNHPLFWDEPKML-SF-------LQD-VSDRVEKL
IRE2_Mmus KVVALDLVRAMLSLLPQDRPSAGWVLAHPLFWSRAKEL-QF-------FQD-VSDWLEKE
IRE1_Mmus DVIARELIEKMIAMDPQQRPSAKHVLKHPFFWSLEKQL-QF-------FQD-VSDRIEKE
ire-1_Cele WSLADDLISSMLNVEPLHRLTADAVLNHPFFWTSEKRL-AY-------FSD-VSDRVEKE
IRE1_Scer IAEATDLISQMIDHDPLKRPTAMKVLRHPLFWPKSKKL-EF-------LLK-VSDRLEIE
IreA_Ddis LPDIHQLVHSMIQFEPEKRPDIGECINHPFFWEVHKKL-SF-------LVA-ASDYLEFE
IrlA_Ddis NAPALDLVRLMISQDEKKRPTIDTILNHPLFWSTNEKI-KF-------YES-SLNLLK-D
IrlB_Ddis NQLACTLIKSMISKDESIRPTIQNVLNHPLFWNLEKKI-QF-------IDA-ALNLIK-E
IrlB_C2d_Ddis NQLACTLIKSMISKDESIRPTIQNVLNHPLFWNLEKKI-QF-------IDA-ALNLIK-E
IrlC_Ddis NLVACDLISQMISKNESDRPTIEKILLHPFFWNHEKKV-KF-------IDA-SLNLFK-D
IrlD_Ddis NLVACDLISQMISKNESDRPTTENILLHPFFWNHEKKV-KF-------IDA-SLNLFK-D
IrlE_Ddis NLVATHLIELMISYDESKRPTLSSVLKHPLFWDSLKKI-KF-------LES-SLRLLG-D
IrlF_Ddis NLLACDLIKSMISNDESKRPTIENVLNHPLFWNVEKKI-QF-------IDA-ALNICK-E
IrlF_C2d_Ddis NLLACDLIKSMISNDESKRPTIENVLNHPLFWNVEKKI-QF-------IDA-ALNICK-E
10577_Tthe DETLKDLIQKMIHNDQSKRLTVKECLKHPYFWNTLQKF-SF-------ICE-FSDYIETF
IRE1_Spur DEIAHQLITQMVDPYFDTRPEANAILRHPFFWYPEKQL-AF-------FQD-VSDRIEKE
CC1G_06931_Ccin GTEACDLIEKMLDPEASERPDTTACLLHPFFWDPARRL-NF-------LQD-ASDRFEIM
AqueK159_Aque KPVARALIKNMMKHNKDSRPSASEVLDDPYFKEDDSQD-TIL-----LSPD-K-E-----
AqueK160_Aque RETAKHLIKQMIHKDKDLRISVEEVLNHCYFWSNERQL-DF-------LEA-ASDILEFM
AqueK161_Aque KPKATALIKKTIQLDRASRPSASEVLDDPYFQEDDPQD-TIH-----VPP-QLTEGEEAP
AqueK162_Aque KPKATALILKMIKRDRASRPSASEVLDDPYFKEDDSQD-TIQ-----VLPQ-LTDGEEAP
AqueK163_Aque KPIASALINKMIQHNRASRPSASEVLQDPYFKEDDPQD-TVH-----VPPQ-VTEGEEAP
AqueK164_Aque WTVGDTLDTNGMNNEEYKKKYQQQLQTGRRIWLEEYQK-PR-------KGD-TADIEQTV
AqueK165_Aque KPKATALIFKMITRDRASRPSASEVLDDRYFKEDDPQD-TVQ-----VPQPQLTEGEEAP
AqueK166_Aque KPLARALIKNMIKYNKDSRPCASEVLGDPYFKEDGPQD-IIQ-----VPQD-S-E-----
AqueK167_Aque KPKAKDLIEKMIQLDKYSRPTASVVLQDPYFEEDGHVPCEYKKKSPSTFPD-TSQTNIAP
AqueK168_Aque RYTAEHLVNNMISFNSKLRPTADEVLHHCLFWSKSRQM-SF-------FQD-VSDRIEKE
AqueK169_Aque REPAKDLIVQMIHENKDLSVV--------------------------------SDIYK--
IRE-2_Smoe YPEAIDIISSLLAMDPKDRPTSMQVKLHPFFWPPQQRL-QF-------LIT-ASDRVERE
IRE-1_Smoe YPEAIDIISSLLAMDPKDRPTAMQVKLHPFFWPPQQRL-QF-------LIT-ASDRVERE
: :
IRE2_Hsap SE--QE--------------------------------------PLVR------------
IRE1_Hsap SL--DG--------------------------------------PIVK------------
ire-1_Dmel QF--HA--------------------------------------EPLK------------
IRE2_Mmus PD--QG--------------------------------------PLVS------------
IRE1_Mmus AL--DG--------------------------------------PIVR------------
ire-1_Cele ED--NS--------------------------------------PVVR------------
IRE1_Scer NRDPPS--------------------------------------ALLM------------
IreA_Ddis KPTSP----------------------------------------LNL------------
IrlA_Ddis PNNSQS--------------------------------------KHSKLLNY--------
IrlB_Ddis PSNSSYN------------------------------------SKLTKQL----------
IrlB_C2d_Ddis PSNSSYN------------------------------------SKLTKQL----------
IrlC_Ddis SNGL-FT------------------------------------SKLNKLINYQEINLK--
IrlD_Ddis SNGL-FT------------------------------------SKLNKLINQFQD-----
IrlE_Ddis HDFK--K------------------------------------FNINKILISCNSNSSSS
IrlF_Ddis SNNSGGG---------------------GGG------------NKFNKSLNYLF------
IrlF_C2d_Ddis SNNSGGG---------------------GGG------------NKFNKSLNYLF------
10577_Tthe DTENKY----------------------------------------SDLI----------
IRE1_Spur PL--DC--------------------------------------PLLV------------
CC1G_06931_Ccin CRDPKD--------------------------------------PLLL------------
AqueK159_Aque ------------------------------------PKQNSLDNLYDKQLYHVMV-----
AqueK160_Aque P--STKD-HMIEH-----------------------------------------------
AqueK161_Aque QGATLQDTSEVQDGASIPP-----------------PEQSVTDTSYGKQLHNSMS-----
AqueK162_Aque QVDTPQDTSEVQDGASILLPEESVS-----------------------------------
AqueK163_Aque QVDTPQDTSEVQDEASILPPEQSVSADGEGHVSIPSPEQSVTDTSYGEQLYAVMS-----
AqueK164_Aque -------------------------------------------QALMK------------
AqueK165_Aque QGATPQDTIEVQDEASILPPEQSVSANGEGHTSIPSPEQSVTDTSYGKQLYDVML-----
AqueK166_Aque ------------------------------------PDQN---KVYGKQLYHAMV-----
AqueK167_Aque IIPTPDGT----NTAVTLTPANPDSS-------------------------NATV-----
AqueK168_Aque TP--QS--------------------------------------AVVQ------------
AqueK169_Aque ----------TQT-----------------------------------------------
IRE-2_Smoe DREASS--------------------------------------AVLT------------
IRE-1_Smoe DREASS--------------------------------------AVLT------------
IRE2_Hsap -----------------------------------------ALEAGGCAVV--RDNWHE-
IRE1_Hsap -----------------------------------------QLERGGRAVV--KMDWRE-
ire-1_Dmel -----------------------------------------SLEKNGRIVV--LDDWNV-
IRE2_Mmus -----------------------------------------ALEAGSYKVV--REDWHK-
IRE1_Mmus -----------------------------------------QLERGGRAVV--KMDWRE-
ire-1_Cele -----------------------------------------RIETDARIVV--CGGWRE-
IRE1_Scer -----------------------------------------KFDAGSDFVIP-SGDWTV-
IreA_Ddis -----------------------------------------EIDSHVDLVTDGSGDWWL-
IrlA_Ddis --------------------------YQ-------------NDNSGGVLFL--SKPWNQ-
IrlB_Ddis ---------------------------N-------------HCDDNDEPFL--NDSWNH-
IrlB_C2d_Ddis ---------------------------N-------------HCDDNDEPFL--NDSWNH-
IrlC_Ddis NNI-DSSSSNNNNNINSNVIN-NNNNNN-------------NGMATNIPFL--SKPWNQ-
IrlD_Ddis --------------------------TD-------------GVNTTSTPFL--SKPWNQ-
IrlE_Ddis NSICNSS---NSSSSSSSSISSS---SC-------------KISSSSCYCV--PLPWNQ-
IrlF_Ddis ------------------VISLS---SD-------------YIEPKSEPFL--KQTWDK-
IrlF_C2d_Ddis ------------------VISLS---SD-------------YIEPKSEPFL--KQTWDK-
10577_Tthe ---------------------------E-------------Q-QAKSLNVLE-GNRWDK-
IRE1_Spur -----------------------------------------ALETGAQNVV--RGDWRN-
CC1G_06931_Ccin -----------------------------------------QLETGALAIV--GNDWHA-
AqueK159_Aque ---------------------NI---SRSLPEFIVDHYMRLMAVVGVKSGI--EPDWSLS
AqueK160_Aque ---------------------------------------------GAADVI--GTNWMN-
AqueK161_Aque ---------------------DM---SHSLPRYIVDQYIRLLTIVGVKCDM--KPDWSLS
AqueK162_Aque -----------------------------------------------------EHASHA-
AqueK163_Aque ---------------------DM---SHSLPGYIVDQYIRLLAIINVKCDM--KPDWLLS
AqueK164_Aque --------------------SL-----E-------------EKEREAQV-------YHQ-
AqueK165_Aque ---------------------NM---SHSLPRYIVDQYIRLLAIINVKCDV--KPDWSLS
AqueK166_Aque ---------------------SI---SHSVPQYIVDNYTRLLAVVGVKSYI--KPDWSLS
AqueK167_Aque ---------------------TI---SDYV------------------------------
AqueK168_Aque -----------------------------------------SLERGANHVI--KGDWRD-
AqueK169_Aque ---------------------------------------------GT-------------
IRE-2_Smoe -----------------------------------------ALEAVAPTAL--GGAWDE-
IRE-1_Smoe -----------------------------------------ALEAVAPTAL--GGAWDE-
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque RRFLELYSTHASKKSPQVAA---------------------SYVDKILTGLGYEEMGEFS
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque KKFLELYSTHTSEKSPQVAA---------------------SYVYKILTGLGYEEMGDFR
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque KKFLELYSTHVSNTSPQVAA---------------------SYVYKILTGLGYEEMDDFS
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque RRFLELYSTHASEKSPQVAA---------------------SYVYKILTGLGYEEMEDFR
AqueK166_Aque KRFLELYSTHASQTSPQVAA---------------------SYVDKILTGLGYEEIKSFK
AqueK167_Aque -----TTSTITAEEAPQASQVDGDEASKPSKHQNEASSITESGLEEFIDGQVVDEIKTDS
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ----------------------------------HISMPLQTDL----------------
IRE1_Hsap ----------------------------------NITVPLQTDL----------------
ire-1_Dmel ----------------------------------HLDPMITDDL----------------
IRE2_Mmus ----------------------------------HISAPLQADL----------------
IRE1_Mmus ----------------------------------NITVPLQTDL----------------
ire-1_Cele ----------------------------------KICDALKEDL----------------
IRE1_Scer ----------------------------------KFDKTFMDNL----------------
IreA_Ddis ----------------------------------KIDQVLIDNI----------------
IrlA_Ddis ----------------------------------IIDPFLIDHV------ENNNNN----
IrlB_Ddis ----------------------------------LIDVTNLL------------------
IrlB_C2d_Ddis ----------------------------------LIDVTNLL------------------
IrlC_Ddis ----------------------------------LIDQTLIEHI------INKQNQLN--
IrlD_Ddis ----------------------------------LIDPTLIEHI------TNKQNQLSGG
IrlE_Ddis ----------------------------------SLDYQLVDSL------SN--------
IrlF_Ddis ----------------------------------LIDINNL-------------------
IrlF_C2d_Ddis ----------------------------------LIDINNL-------------------
10577_Tthe ----------------------------------NVDKSLIQDT----------------
IRE1_Spur ----------------------------------NITEELQTDL----------------
CC1G_06931_Ccin ----------------------------------RLDRLFVENL----------------
AqueK159_Aque VY-------------RY--LHTE----------VDIDSKVNEKL------E---------
AqueK160_Aque ----------------------------------QIDA---T--------D---------
AqueK161_Aque AY-----------------LHTE----------VEIDSKITEEL------E---------
AqueK162_Aque ----------------------------------RIHSILLPEE------S---------
AqueK163_Aque AY-----------------LHTE----------VEIDTKINEEL------E---------
AqueK164_Aque ----------------------------------QLEQKEREEAKKDQKIRRYRHQ----
AqueK165_Aque AY-----------------LHTE----------VEIDTKINEEL------E---------
AqueK166_Aque AY-----------------LRFD----------VDIDSKVTEKL------K---------
AqueK167_Aque DLVYNALNNGVKKSVFLDEIKVATQEKAITFQKLENDIALTKDI------K---------
AqueK168_Aque ----------------------------------HIGEELRQDL----------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ----------------------------------KLDPLLINNL----------------
IRE-1_Smoe ----------------------------------KLDPLLINNL----------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ----NN--------------------------NNNNN-----------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------G-----------------------
IrlD_Ddis SSIGNN--------------------------NNNSL-----------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ----LQEKDREHQVVLQENQEALQQKDRKHQVVLQELQEKDREHQVVLQEKDREHQVVLQ
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ----------------RKFRSYKGTSVRD-------------------LLRA-VRNKKHH
IRE1_Hsap ----------------RKFRTYKGGSVRD-------------------LLRA-MRNKKHH
ire-1_Dmel ----------------RKYRGYMGASVRD-------------------LLRA-LRNKKHH
IRE2_Mmus ----------------KRFRSYKGTSVRD-------------------LLRA-MRNKKHH
IRE1_Mmus ----------------RKFRTYKGGSVRD-------------------LLRA-MRNKKHH
ire-1_Cele ----------------RKFRTYKSFSVRD-------------------LLRA-MRNKKHH
IRE1_Scer ----------------ERYRKYHSSKLMD-------------------LLRA-LRNKYHH
IreA_Ddis ----------------GRYRKYNGKSIRD-------------------LLRV-IRNKFNH
IrlA_Ddis ----KQ------NSKKLAIVAYQYDQVRD-------------------LVRC-IRNSLVH
IrlB_Ddis ----TP------TKGSKITISYQYDKVRD-------------------LIRF-IRNTIAH
IrlB_C2d_Ddis ----TP------TKGSKITISYQYDKVRD-------------------LIRF-IRNTIAH
IrlC_Ddis ----VG------N--NKKVIIYSFDQVKD-------------------LVRC-IRNTIQH
IrlD_Ddis ----TL------S--GKKFYFYDYSQVKD-------------------LVRC-IRNTIQH
IrlE_Ddis -----Q------I--EKKVASYKFDQLHD-------------------LIRF-IRNTLQH
IrlF_Ddis ------------S--IGSTSQYQYDQIKD-------------------LIRF-IRNTIVH
IrlF_C2d_Ddis ------------S--IGSTSQYQYDQIKD-------------------LIRF-IRNTIVH
10577_Tthe ----------------KVFKFYNYGQVKD-------------------LIRL-IRNRKSH
IRE1_Spur ----------------RKFRAYRGHSVRD-------------------LLRA-MRNKKHH
CC1G_06931_Ccin ----------------GKFRKYDGKSVQD-------------------LLRA-LRNKKHH
AqueK159_Aque --------------KIMKFRPAVIQVVRE-LCLCLHDYQVERYRMVVTLLRRTALDSNKS
AqueK160_Aque ---------------I--PGNYDPTLVKD-------------------LLRA-IKAKKHS
AqueK161_Aque --------------KITEFRPAIIKVVRDELGPRLGDYQIDRYRMVLTVLCSITFDSNKS
AqueK162_Aque --------------VSAHA----------------------SHASIPSPGQS-VSADGED
AqueK163_Aque --------------KITEFRPAVIKVIRGELGPRLGDYQIDRYRMVLTVLCITTFDSNKS
AqueK164_Aque EKDREL------RQSQEAVRRYQQQALTD-------------------DHWV-IN-KD--
AqueK165_Aque --------------KITEFRPAVIKVIRDELGPRLGDYQIDRYRMVLTVLCSIAFDSNKS
AqueK166_Aque --------------ELKEFRPAVIQVVYA-LGLCLNSHQVERYRMVVTVLRGTALDANKS
AqueK167_Aque -----DVYAASQFIKAAKFDAYNSTIETD-------------------LVPA-PIPPSAL
AqueK168_Aque ----------------RRFRSYQGTSLRD-------------------LLRA-MRNKKHH
AqueK169_Aque --------------------------------------------------KF-ILNTDHK
IRE-2_Smoe ----------------GRYRQYNYQAVRD-------------------LLRV-IRNKANH
IRE-1_Smoe ----------------GRYRQYNYQAVRD-------------------LLRV-IRNKANH
IRE2_Hsap YRELPVEVRQALG-----------------------------------------------
IRE1_Hsap YRELPAEVRETLG-----------------------------------------------
ire-1_Dmel YHELTPAAQKMLG-----------------------------------------------
IRE2_Mmus YRELPAEVRQTLG-----------------------------------------------
IRE1_Mmus YRELPVEVQETLG-----------------------------------------------
ire-1_Cele YRELPEDVRQSLG-----------------------------------------------
IRE1_Scer FMDLPEDIAELMG-----------------------------------------------
IreA_Ddis YRDLSPEEQTCLG-----------------------------------------------
IrlA_Ddis HKDILRSITQQQN-LPPSSK----------------------------------------
IrlB_Ddis HKEIKRAIIQQFQNQQSRPN----------------------------------------
IrlB_C2d_Ddis HKEIKRAIIQQFQNQQSRPN----------------------------------------
IrlC_Ddis HKEIQRLVRQSPS-SNGDNK----------------------------------------
IrlD_Ddis HKEIQRLISQSPS-SS--NK----------------------------------------
IrlE_Ddis YNQIYRDLKQILP-NS--------------------------------------------
IrlF_Ddis HKDIKRLIQQQQQ-QQKQPT----------------------------------------
IrlF_C2d_Ddis HKDIKRLIQQQQQ-QQKQPT----------------------------------------
10577_Tthe YHELSESSKDIVG-----------------------------------------------
IRE1_Spur FRELPEEVKASLG-----------------------------------------------
CC1G_06931_Ccin YQDLPDNVKRSLG-----------------------------------------------
AqueK159_Aque FLELFMDLTQELG-KYPLAVAITLGVLEKSDWGDTGKLKPFSLPNFDLNTSYPEVDLCLT
AqueK160_Aque AGIVSVSS----------------------------------------------------
AqueK161_Aque FFELFTDLTGNLG-KYPLAVSLTIGVLERSGWGDTKKLKLFSLPNFDINTSYPKIYLCLT
AqueK162_Aque YTSIPSPE-QSLS-ADG-------------------------------------------
AqueK163_Aque FFELFTDLTGNLG-KYPLAVSLTIGVLERSGWGDTKKLKPFLLPNFDLNTSYPKIDLCLT
AqueK164_Aque --EV-TLTKEELG-----------------------------------------------
AqueK165_Aque FFELFADLTGNLG-KYPLAVSLTIGVLERSGWGDTKKLKPFSLPNFDLNTSYPKIDLCLT
AqueK166_Aque FIRLFTDLMEELG-KYPLAVAITVGVLERSDWGDTRKLKPFSLPNFDINTSYPKIDLCLT
AqueK167_Aque FPELSN--IQCVS-ELPDHL----------------------------------------
AqueK168_Aque YRELPETLKESLG-----------------------------------------------
AqueK169_Aque AGDQQET-----------------------------------------------------
IRE-2_Smoe YRELPADVQQILG-----------------------------------------------
IRE-1_Smoe YRELPADVQQILG-----------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque VAGYYGYMRDLDFSNAKVYTSSLHLKSHNVSNMSRVQFTRLLMERGVLEAGDVSKLEDKD
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque VADYYGNMSQRDFSSAKVYTSSLHLNSHNVSNMSRVQFTLLLMERGVIEVGDVSKIEDND
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque VADYYGNMSQRDFSSAKVYTSSLHLNSHNVSNMSRVQFTLLLMERSVIEAGNVSKIEDKV
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque VADYYGNMSQRDFSSAKVYTSSLHLKSHNVSNMSRVQFTRLLMERSVVEAGNVSNIEDTV
AqueK166_Aque VADYYGKMSDIDFSSAKVCTSVVHLKSHNVSNMSRVQFTLLLMERGVIEAGDVSKIEDKI
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque RYPLFFKKYKKRCKGKEL------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque RYPLFFKKYKQRCKGPSKVTAPATDET----------VAVQQRKAQATSGQSPSTSTDQP
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque RYPIFFKEYEKRCKGPTKVTAPATNETVVPSLP------IQEMKAQATSSQSPSTPTDQP
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque RYPTFFEKYEKRCKGPSKETAPMTNETVVPSLPTQETVPIQEIKAQATLGQSPSAPTDQP
AqueK166_Aque RYPIFFEKYKQRCKGPSKET----------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ----------------------------------------------------QVPD----
IRE1_Hsap ----------------------------------------------------SLPD----
ire-1_Dmel ----------------------------------------------------CIPH----
IRE2_Mmus ----------------------------------------------------QLPA----
IRE1_Mmus ----------------------------------------------------SIPD----
ire-1_Cele ----------------------------------------------------DIPD----
IRE1_Scer ----------------------------------------------------PVPD----
IreA_Ddis ----------------------------------------------------ILPD----
IrlA_Ddis --------------------------------------------EFANDCL-KSQE----
IrlB_Ddis -----------------------------------------LE---VLEYL-SSQD----
IrlB_C2d_Ddis -----------------------------------------LE---VLEYL-SSQD----
IrlC_Ddis -----------------------------------------QE---VLDCL-ESQE----
IrlD_Ddis -----------------------------------------QE---VLDCL-ESQE----
IrlE_Ddis ------------------------------------------D---ILESL-KSQQ----
IrlF_Ddis -----------------------------------------IELQFINNIL-TNQD----
IrlF_C2d_Ddis -----------------------------------------IELQFINNIL-TNQD----
10577_Tthe ----------------------------------------------------DTLD----
IRE1_Spur ----------------------------------------------------KVPD----
CC1G_06931_Ccin ----------------------------------------------------PMPE----
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque SFLTQSRKHKISSNYSGILPCVGGRGSPTGDVHIYVKRILPES---VLQKDSK-------
AqueK162_Aque ---------------ED-------------------YISIPPE---QSKQLYAV------
AqueK163_Aque NIFTRVKNFFLPSSKQQ-------------------AQEVPGT---TTQAKEPTPESSNT
AqueK164_Aque ----------------------------------------------------RGSY----
AqueK165_Aque NFFTRVKKFFLPSSKQE-------------------AQEVPGT---TTQAKEPTPESSNT
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ----------------------------------------------------QIPD----
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ----------------------------------------------------SIPQ----
IRE-1_Smoe ----------------------------------------------------SIPQ----
IRE2_Hsap -----------------------------------------------------------G
IRE1_Hsap -----------------------------------------------------------D
ire-1_Dmel -----------------------------------------------------------E
IRE2_Mmus -----------------------------------------------------------G
IRE1_Mmus -----------------------------------------------------------D
ire-1_Cele -----------------------------------------------------------Q
IRE1_Scer -----------------------------------------------------------G
IreA_Ddis -----------------------------------------------------------G
IrlA_Ddis -----------------------------------------------------------S
IrlB_Ddis -----------------------------------------------------------S
IrlB_C2d_Ddis -----------------------------------------------------------S
IrlC_Ddis -----------------------------------------------------------L
IrlD_Ddis -----------------------------------------------------------L
IrlE_Ddis -----------------------------------------------------------S
IrlF_Ddis -----------------------------------------------------------S
IrlF_C2d_Ddis -----------------------------------------------------------S
10577_Tthe -----------------------------------------------------------D
IRE1_Spur -----------------------------------------------------------Q
CC1G_06931_Ccin -----------------------------------------------------------G
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque APAPTVTSAAKEGTLPAPAPPIAATVPASTPPTAPIVSPPISPTATVPAPVPLPELFPEK
AqueK164_Aque -----------------------------------------------------------A
AqueK165_Aque APAPTVTSAAKEGTF------------------------------------PPPEL----
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque -----------------------------------------------------------G
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe -----------------------------------------------------------G
IRE-1_Smoe -----------------------------------------------------------G
IRE2_Hsap FVQYFTNRFPRL------------------------------------------------
IRE1_Hsap FVCYFTSRFPHL------------------------------------------------
ire-1_Dmel FTNYWVDRFPQL------------------------------------------------
IRE2_Mmus FIQYFTQRFPRL------------------------------------------------
IRE1_Mmus FVRYFTSRFPHL------------------------------------------------
ire-1_Cele FLHYFTSRFPRL------------------------------------------------
IRE1_Scer FYDYFTKRFPNL------------------------------------------------
IreA_Ddis FFNYFDLKFPQL------------------------------------------------
IrlA_Ddis VLLYFECKFPDL------------------------------------------------
IrlB_Ddis ILLYFESKIPNL------------------------------------------------
IrlB_C2d_Ddis ILLYFESKIPNL------------------------------------------------
IrlC_Ddis VLSYFEEKVPDL------------------------------------------------
IrlD_Ddis VLSYFEEKVPDL------------------------------------------------
IrlE_Ddis ALNYFESKFPTL------------------------------------------------
IrlF_Ddis ILFYFESKIPNL------------------------------------------------
IrlF_C2d_Ddis ILFYFESKIPNL------------------------------------------------
10577_Tthe MFNYFDERFPKL------------------------------------------------
IRE1_Spur FVKYFTSRFPLL------------------------------------------------
CC1G_06931_Ccin FLAYFTKRFPRL------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ----VTHRFPML------------------------------------------------
AqueK161_Aque --------------------IKTGDELVAVNDLIIHNVTKDYATEALTNVQGAFKLHPIT
AqueK162_Aque -MLNMSHSLPRY------------------------------------------------
AqueK163_Aque GEKEYETKLPEE------------------------------------------------
AqueK164_Aque VV----------------------------------------------------------
AqueK165_Aque --------FPELNKKEYETKL---------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque -VENI-------------------------------------------------------
AqueK168_Aque YVTYFTSRFPAL------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe YESYFRTRFPKL------------------------------------------------
IRE-1_Smoe YESYFRTRFPKL------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ITPTFYCNSNTPPMLPYIKEHSEHTLSASDLFRSISARLKDSISSDLFVVSTSLYAKNLI
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque TTQLHQEITGAHGSNSNKAAKLVNVLQDSLDAHTNPEAYLQEVCSALKDVGQKQIVDVVH
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ELEPTLSISMVQLNDSSSASIPTDEHKETPVTDRVQRIKKWLEEGEVELEITRINMHGAP
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque GATATATDKIDIEKLENWLKEGKVVLEITRINMHGLPGAGKTCSQRLLLNEPPPAPPGKL
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque TDSTPIACRAVQATRISIDDKSKKWKRVEIEDLLKEL-----------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ----------------------------HVKGIIKDFRVLLMTATEVELRGVLGYLKPLD
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque -------------------------SEGHVKDIVKDSRILLMTATDVELRGVLGYLKPLD
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque -------------------------------------EYLLMTATATELRGVLGHLKPLD
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------LLHT--HRA---
IRE1_Hsap ------------------------------------------------LAHT--YRA---
ire-1_Dmel ------------------------------------------------ISHA--YHA---
IRE2_Mmus ------------------------------------------------LLHT--HRA---
IRE1_Mmus ------------------------------------------------LSHT--YQA---
ire-1_Cele ------------------------------------------------LLHV--YKA---
IRE1_Scer ------------------------------------------------LIGV--YMI---
IreA_Ddis ------------------------------------------------FIVT--YLF---
IrlA_Ddis ------------------------------------------------LFHL--YQQ---
IrlB_Ddis ------------------------------------------------IHHI--YQQ---
IrlB_C2d_Ddis ------------------------------------------------IHHI--YQQ---
IrlC_Ddis ------------------------------------------------LLFL--YQK---
IrlD_Ddis ------------------------------------------------LLFL--YQK---
IrlE_Ddis ------------------------------------------------IIFL--FNH---
IrlF_Ddis ------------------------------------------------IYHL--YKQ---
IrlF_C2d_Ddis ------------------------------------------------IYHL--YKQ---
10577_Tthe ------------------------------------------------FIFM--YYF---
IRE1_Spur ------------------------------------------------LLHV--YDA---
CC1G_06931_Ccin ------------------------------------------------FLHV--HRV---
AqueK159_Aque -------------------------------------------------------NP-FP
AqueK160_Aque ------------------------------------------------LMHV--YNQ---
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------IVDH--Y-----
AqueK163_Aque GRDRIIKSFINGTWIYVGMYGGYSVVVGKSADSKGQQGGLDALIITNKIMEI--YKPRYI
AqueK164_Aque ------------------------------------------------TVGI--FRG---
AqueK165_Aque GWDKVIKSFINNTRIYVGKCGGYSVVVGRSANAKSQQGGLDALTITNKIMEI--FKPKYI
AqueK166_Aque ------------------------------------ETVMPSLTSQDTVATQ--ETVAIQ
AqueK167_Aque GQNKIIRAFVNATWIYIGKFGQQVVVVGKSAHGEAEQGGLDAATVTKKIMAINQFKPKYI
AqueK168_Aque ------------------------------------------------LVHT--YKQ---
AqueK169_Aque ------------------------------------------------LQHI--YTK---
IRE-2_Smoe ------------------------------------------------LMEV--YKV---
IRE-1_Smoe ------------------------------------------------LMEV--YKV---
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque LK----------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ---------------------------------------------------------ASH
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque IAVGICFGMDHSKVNLGDVIVSNFIVDFFNFRKQPESITARKPQPPAGRTLLRFFGETSK
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque IAVGICFGMDRSKVNLGDVIVSDFIVDLSDFRKEPGSIIPRKPQPPAGTTLSSFFSDISG
AqueK166_Aque ET----------------------------------------------------------
AqueK167_Aque ISIGICFGMDRSTVQLGDVIVSNMIVDLSTMDKEKDKVKARKSQPPAGPSLLSLFGDSSG
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap --------------------------------------------------------M-R-
IRE1_Hsap --------------------------------------------------------M-E-
ire-1_Dmel --------------------------------------------------------F-S-
IRE2_Mmus --------------------------------------------------------M-R-
IRE1_Mmus --------------------------------------------------------M-E-
ire-1_Cele --------------------------------------------------------T-E-
IRE1_Scer --------------------------------------------------------V-K-
IreA_Ddis --------------------------------------------------------I-L-
IrlA_Ddis --------------------------------------------------------F-K-
IrlB_Ddis --------------------------------------------------------L-K-
IrlB_C2d_Ddis --------------------------------------------------------L-K-
IrlC_Ddis --------------------------------------------------------F-K-
IrlD_Ddis --------------------------------------------------------F-K-
IrlE_Ddis --------------------------------------------------------F-S-
IrlF_Ddis --------------------------------------------------------L-K-
IrlF_C2d_Ddis --------------------------------------------------------L-K-
10577_Tthe --------------------------------------------------------S-Q-
IRE1_Spur --------------------------------------------------------L-S-
CC1G_06931_Ccin --------------------------------------------------------I-S-
AqueK159_Aque -------------------------------------------------------VLTT-
AqueK160_Aque --------------------------------------------------------M-K-
AqueK161_Aque LKKKMKDEEISTEVDKAPKPKIDAPNHSDELPLAKPIKNEPAPTKNEP-VLTKNEPVSTE
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque FEIKHSDQENPKEVE-----------------------VHCGPIASTP-ALVDDPKFKEE
AqueK164_Aque --------------------------------------------------------L-R-
AqueK165_Aque FKMKHSQEENAKEVN-----------------------VHCGPIASSP-VLVDDEEFKEQ
AqueK166_Aque -------------------------------------------------------EGQA-
AqueK167_Aque FQKKHSAEENAKEVK-----------------------VHCGPVVSSFVSLVDDAEFKEQ
AqueK168_Aque --------------------------------------------------------M-E-
AqueK169_Aque --------------------------------------------------------I---
IRE-2_Smoe --------------------------------------------------------I-A-
IRE-1_Smoe --------------------------------------------------------I-A-
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque NQLVSTKNEPAPAENELAPAENEEAKNKPTENAESTKINQDTDMKVIKEIADSLADRKFQ
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque LREVRPDTLGGEMEGAAILHA-------------ASEAHHKVEAIVIKAVGDL-ADGKKD
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque LSKARPDALAGEMEGAAIFSA-------------ARHAHHKPEVIVIKAVGDW-GDGKKD
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque LKEVRPDALGGEMEGAGIFLA-------------ARDAHHKVEAIVIKAVADW-GDGRKD
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap -----------S------------------------------------------------
IRE1_Hsap -----------L------------------------------------------------
ire-1_Dmel -----------I------------------------------------------------
IRE2_Mmus -----------T------------------------------------------------
IRE1_Mmus -----------L------------------------------------------------
ire-1_Cele -----------Y------------------------------------------------
IRE1_Scer -----------E------------------------------------------------
IreA_Ddis -----------K------------------------------------------------
IrlA_Ddis -----------K------------------------------------------------
IrlB_Ddis -----------Q------------------------------------------------
IrlB_C2d_Ddis -----------Q------------------------------------------------
IrlC_Ddis -----------K------------------------------------------------
IrlD_Ddis -----------K------------------------------------------------
IrlE_Ddis -----------A------------------------------------------------
IrlF_Ddis -----------E------------------------------------------------
IrlF_C2d_Ddis -----------E------------------------------------------------
10577_Tthe -----------T------------------------------------------------
IRE1_Spur -----------L------------------------------------------------
CC1G_06931_Ccin -----------D------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque -----------Y------------------------------------------------
AqueK161_Aque ELSTNWVYFIDSGGQPAYRELLPLFTRAAALNIITIDLTKGLDKNCEFQYRISQNMFPIK
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque E-CRGWKDFASH------------------------------------------------
AqueK164_Aque -----------V------------------------------------------------
AqueK165_Aque E-CRGWKDFASH------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque E-CRGWKDFASY------------------------------------------------
AqueK168_Aque -----------M------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe -----------D------------------------------------------------
IRE-1_Smoe -----------D------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel ------------------------------------------------------------
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele ------------------------------------------------------------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ------------------------------------------------------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque TKLEYSNLDIIQSTISSEAMLNPIEIPYVSESDMPKHPHYLILGTRIDELKEKGMLNRLD
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap -------------------------------------------CASES---LFLPYYPPD
IRE1_Hsap -------------------------------------------CSHER---LFQPYYFHE
ire-1_Dmel -------------------------------------------CSNEP---IFKPYYSAG
IRE2_Mmus -------------------------------------------CASES---LFLPYYPPA
IRE1_Mmus -------------------------------------------CRHER---LFQTYYWHE
ire-1_Cele -------------------------------------------CSGEA---VFKRYYSDD
IRE1_Scer -----------------------------------------NL-SDDQ---ILREF----
IreA_Ddis -----------------------------------------NL-KNDQ---YF-------
IrlA_Ddis -----------------------------------------SD-FNSK---DY-------
IrlB_Ddis -----------------------------------------YS-LTID---YL-------
IrlB_C2d_Ddis -----------------------------------------YS-LTID---YL-------
IrlC_Ddis -----------------------------------------HL-DSKS---LI--YF---
IrlD_Ddis -----------------------------------------HL-DSKS---LI--YF---
IrlE_Ddis -----------------------------------------IP-EIKN---SI--HFSN-
IrlF_Ddis -----------------------------------------YS-SSFD---YL-------
IrlF_C2d_Ddis -----------------------------------------YS-SSFD---YL-------
10577_Tthe ------------------------------------------Q--NWE---LL-------
IRE1_Spur -------------------------------------------CREEP---VLSKYYYNS
CC1G_06931_Ccin -----------------------------------------TVLRTES---MFRSYFE--
AqueK159_Aque -----------------------------------------------Y-----DRTN---
AqueK160_Aque -------------------------------------------YDK-T-----LSYY---
AqueK161_Aque NMNKKLINEGFNNLIKRNEGKGSVIFPVNTLLLAGSKEREKASEEL-C-----TEVS---
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque -------------------------------------------AAATFVHD--KLNI---
AqueK164_Aque -----------------------------------------A--VKSL---HT-------
AqueK165_Aque -------------------------------------------AAATYIHH--HLND---
AqueK166_Aque -----------------------------------------------T-----SVPS---
AqueK167_Aque -------------------------------------------AAATYVHHQMNKVV---
AqueK168_Aque -------------------------------------------CCNEP---VFKAYYS--
AqueK169_Aque -----------------------------------------------Y-----VEYV---
IRE-2_Smoe -----------------------------------------HC-WEEE---MFQPYFSE-
IRE-1_Smoe -----------------------------------------HC-WEEE---MFQPYFSE-
IRE2_Hsap SEARR-------------------------------------------------------
IRE1_Hsap PPEPQ-------------------------------------------------------
ire-1_Dmel YLFTRPWYFDADDALFPMLMLDPKPLPKIGS------PKKTPSPASSQAQQLKQRKGLYN
IRE2_Mmus LEAR--------------------------------------------------------
IRE1_Mmus PTEPQ-------------------------------------------------------
ire-1_Cele VRARM---------Y-PIVEEEERVRKKIKEEMANEVWARAPKPVE-------Q------
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur SKKDV---------H----------------------------TAA--------------
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap ------------------------------------------------------------
IRE1_Hsap ------------------------------------------------------------
ire-1_Dmel FRKPNDELPIPGVGLQRNLELDGQSLEPDGKRDVFANFKFRRYSKPGNNRNYNGGHKEAQ
IRE2_Mmus ------------------------------------------------------------
IRE1_Mmus ------------------------------------------------------------
ire-1_Cele --------------------------------------------------------RTPL
IRE1_Scer ------------------------------------------------------------
IreA_Ddis ------------------------------------------------------------
IrlA_Ddis ------------------------------------------------------------
IrlB_Ddis ------------------------------------------------------------
IrlB_C2d_Ddis ------------------------------------------------------------
IrlC_Ddis ------------------------------------------------------------
IrlD_Ddis ------------------------------------------------------------
IrlE_Ddis ------------------------------------------------------------
IrlF_Ddis ------------------------------------------------------------
IrlF_C2d_Ddis ------------------------------------------------------------
10577_Tthe ------------------------------------------------------------
IRE1_Spur ----------------------------------------------------------AM
CC1G_06931_Ccin ------------------------------------------------------------
AqueK159_Aque ------------------------------------------------------------
AqueK160_Aque ------------------------------------------------------------
AqueK161_Aque ------------------------------------------------------------
AqueK162_Aque ------------------------------------------------------------
AqueK163_Aque ------------------------------------------------------------
AqueK164_Aque ------------------------------------------------------------
AqueK165_Aque ------------------------------------------------------------
AqueK166_Aque ------------------------------------------------------------
AqueK167_Aque ------------------------------------------------------------
AqueK168_Aque ------------------------------------------------------------
AqueK169_Aque ------------------------------------------------------------
IRE-2_Smoe ------------------------------------------------------------
IRE-1_Smoe ------------------------------------------------------------
IRE2_Hsap --------PCPGATGR
IRE1_Hsap --------PPVTPDAL
ire-1_Dmel DKEKYVIWTLPPSTQD
IRE2_Mmus ---------RPDATKS
IRE1_Mmus --------PPVIPYAL
ire-1_Cele KLDKRNIKKKSNPNTD
IRE1_Scer -------------LYS
IreA_Ddis -----------VQYYY
IrlA_Ddis -----------LNIKF
IrlB_Ddis -----------FNFYN
IrlB_C2d_Ddis -----------FNFYN
IrlC_Ddis ----------NDLIIK
IrlD_Ddis ----------NDLIIK
IrlE_Ddis ----------DTCSIF
IrlF_Ddis -----------IKFYN
IrlF_C2d_Ddis -----------IKFYN
10577_Tthe -----------SFKNN
IRE1_Spur SEGDH-IQGVHSNPSQ
CC1G_06931_Ccin ------------LPDS
AqueK159_Aque ---------QGDCSSN
AqueK160_Aque ---------YQISLII
AqueK161_Aque ---------NCRVAIK
AqueK162_Aque ---------IRLLANL
AqueK163_Aque ---------AAPDALK
AqueK164_Aque -----------IIISD
AqueK165_Aque ---------AAPDALK
AqueK166_Aque ---------QSTLTCK
AqueK167_Aque ---------HAGARRP
AqueK168_Aque -------------RSS
AqueK169_Aque ---------IKNPHYK
IRE-2_Smoe -----------ADDYL
IRE-1_Smoe -----------ADDYL