PIM3_Hsap M-----------------------------------------------------------
PIM2_Hsap MAPIGCGTAGAA-SGLIKARWAGLSPRVT--LPGGACPGSVALGLARAANLNAAPSAGAS
PIM1_Hsap MPHEPHEPLTPPFSALPDP-AGAPSRRQSRQRPQLSSDSPSAFRASRSHSRNATRSHSHS
PIM3_Mmus M-----------------------------------------------------------
PIM2_Mmus MARIGWGTAGAA-SGLIKARWAGLSRRAT--LPGGACPGSVALGLARATNLNAAPSAGAS
PIM1_Mmus MGP--AAPLALPPPALPDP-AGEPARGQPRQRPQSSSDSPSALRASRSQSRNATRSLS--
prk-2_Cele MK----------------------------------------------------------
prk-1_Cele MI----------------------------------------------------------
Pim_Spur MNLP--------------------------------------------------------
*
PIM3_Hsap --------------------------------------LLSKFG-SL-A-HLCGPGGVDH
PIM2_Hsap GPPV-SLLSTLAPPSPGSPA-ALPRASTPCGLSGFSGLNLRSAT-SMLTKPLQGPP-APP
PIM1_Hsap HSPRHSLRH-----SPGSGSCGSSSGHRPCADILEVGMLLSKIN-SL-A-HLRAAP-CND
PIM3_Mmus --------------------------------------LLSKFG-SL-A-HLCGPGGVDH
PIM2_Mmus GPPD-SLPSTLAPPSPGSPA-ALPRASTPCGLSGFSGLNIRSTS-SMLTKPLQGHP-SPP
PIM1_Mmus --PGRRLSP-----SSLRRRCC-SSRHRRRTDTLEVGMLLSKIN-SL-A-HLRAAP-CND
prk-2_Cele -----------------------------------------KLA-SL-Q----FF-NL--
prk-1_Cele ---------------------------------------KRKLQ-DL-A-VCCSY-QV--
Pim_Spur ----------------------------------------RKLTSQF-A-EICSMN-VKN
. .:
PIM3_Hsap LPVKILQPAK--ADKESFEKAYQVGAVLGSGGFGTVYAGSRIAD-GLPVAVKHVVKERVT
PIM2_Hsap GTPTP-PPGG--KDREAFEAEYRLGPLLGKGGFGTVFAGHRLTD-RLQVAIKVIPRNRVL
PIM1_Hsap LHATKLAPG---KEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD-NLPVAIKHVEKDRIS
PIM3_Mmus LPVKILQPAK--ADKESFEKVYQVGAVLGSGGFGTVYAGSRIAD-GLPVAVKHVVKERVT
PIM2_Mmus VTPTQ-PPGG--KDRAAFEAEYRLGPLLGKGGFGTVFAGHRVTD-RRQVAIKVISRNRVL
PIM1_Mmus LHATKLAPG---KEKEPLESQYQVGPLLGSGGFGSVYSGIRVAD-NLPVAIKHVEKDRIS
prk-2_Cele ---KLLLNGESSRGFSKFKKNYKLKAELGRGGFGVVYRAVRTCD-NALVAVKFIERSNVK
prk-1_Cele ---DFLHEKK--HSVKEFKRKYEVLDEIGRGGFGIVYEATTRQDGQQPVAVKFVQHKHVR
Pim_Spur MGRTTADRNG--KQRESFEKTYSIGSLIGSGGFGTVYAGSRISD-NLPVAIKLVNKEKVN
:: * : :* **** *: . * **:* : :..:
PIM3_Hsap EWGSL-GGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFI
PIM2_Hsap GWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYI
PIM1_Hsap DWGELPNGTRVPMEVVLLKKVSS--GFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI
PIM3_Mmus EWGSL-GGVAVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFI
PIM2_Mmus GWSTVSDSVTCPLEVALLWKVGEGNGHPGVIRLLDWFETPEGFMLVLERPMPAQDLFDYI
PIM1_Mmus DWGELPNGTRVPMEVVLLKKVSS--DFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFI
prk-2_Cele EWARI-NGEQVPMEICMLAKCS---KVRGVIRLLDWYSIPEGFLIVMERPYPCIDMFDFI
prk-1_Cele SWTMT-CRQLIPSEVCHLETCE---DIPGVIKILDWFANSKGFLIVMERPANCMDLFDMV
Pim_Spur DWVQL-NGREVPLEVSLLKRVSS---IHGCISMLDYFEQPDSFVIVMERPDPAKDLFDFI
* * *: * * * :**:: ..*::::*** *:** :
PIM3_Hsap TERGALDEPLARRFFAQVLAAVRHCHS-CGVVHRDIKDENLLVDLRSGELKLIDFGSGAL
PIM2_Hsap TEKGPLGEGPSRCFFGQVVAAIQHCHS-RGVVHRDIKDENILIDLRRGCAKLIDFGSGAL
PIM1_Hsap TERGALQEELARSFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLNRGELKLIDFGSGAL
PIM3_Mmus TERGALDEPLARRFFAQVLAAVRHCHN-CGVVHRDIKDENLLVDLRSGELKLIDFGSGAV
PIM2_Mmus TEKGPLGESCSRSFFTQVVAAVQHCHA-RGVVHRDIKDENILIDLCRGSIKLIDFGSGAL
PIM1_Mmus TERGALQEDLARGFFWQVLEAVRHCHN-CGVLHRDIKDENILIDLSRGEIKLIDFGSGAL
prk-2_Cele KGQGKISEDMARFLFRQIAVTVHECVQ-NRVLHRDLKDENIVIDLVTGSTKLIDFGAATV
prk-1_Cele SVHGPLNEDMGKFIFKQVITTVFNMYSKHGLLHRDIKDENLIVNMNTGEVKLVDFGATAY
Pim_Spur TEQGPLPEELCRRFFKQMW----------------------------------KLQAAAM
. :* : * : :* *: .: : :
PIM3_Hsap LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGR
PIM2_Hsap LHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAE
PIM1_Hsap LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQ
PIM3_Mmus LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGR
PIM2_Mmus LHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGVLLYDMVCGDIPFERDQEILEAE
PIM1_Mmus LKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIKGQ
prk-2_Cele LRRSQYSDFQGTRLYCPPEWFLHSLYLGREAAVWSLGVLLYNSLNGRLPFRNEKDICTAH
prk-1_Cele AEKATKKEFQGTRSYCPPEWFRDQLYLPLEATSWSLGVLLFILLTGKLPFRNEIQICLGN
Pim_Spur RLDTVYKDFDGTRVYSPPEWITSHRYHGRSATIWSLGILLFDMACGDIPFEKDDEICRAE
.:*:*** *.****: * *: ****:**: * :**..: :* ..
PIM3_Hsap ----LLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV-----PE-S--
PIM2_Hsap ----LHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDV-----PLNP--
PIM1_Hsap ----VFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVL--L-----PQET--
PIM3_Mmus ----LFFRRRVSPECQQLIEWCLSLRPSERPSLDQIAAHPWMLGTEGSV-----PE-N--
PIM2_Mmus ----LHFPAHVSPDCCALIRRCLAPKPCSRPSLEEILLDPWMQSPAEEK-----PINS--
PIM1_Mmus ----VFFRQTVSSECQHLIKWCLSLRPSDRPSFEEIRNHPWMQGDL--L-----PQAA--
prk-2_Cele LLGPLPFFVPVSAEVKDLISKCLTFDPFQRCSLEAILNHPWVKQQTLSW--DALTKNK--
prk-1_Cele ----VKFPPDLSKEVCQLVKSCLTTSTSARASLAQIAAHPWMETDKPFFGGDLTFEEALM
Pim_Spur ----LYFRDGLSHSLKNLIQSMLQVKPQHRLKIEDILDHPWMREGQTDNGGQ--KIIC--
: * :* . *: * . * .: * .**:
PIM3_Hsap ------------------------------------------------------------
PIM2_Hsap ------------------------------------------------------------
PIM1_Hsap ------------------------------------------------------------
PIM3_Mmus ------------------------------------------------------------
PIM2_Mmus ------------------------------------------------------------
PIM1_Mmus ------------------------------------------------------------
prk-2_Cele -------------------------VQ---------------------------------
prk-1_Cele EIKNPPVVIEDKEAEEEDNDLNDVVILTRSRESRTDLDAESICTMVTAVEDRYEPSIAVK
Pim_Spur ------------------------------------------------------------
PIM3_Hsap -------------------------------CD-LRLCTLDPDDVAST------------
PIM2_Hsap -------------------------------SK----------GGPAP------------
PIM1_Hsap -------------------------------AE-IHL---------HS------------
PIM3_Mmus -------------------------------CD-LRLCALDTDDGAST------------
PIM2_Mmus -------------------------------SK----------GSPTP------------
PIM1_Mmus -------------------------------SE-IHL---------HS------------
prk-2_Cele -----------------------------------KKTSESSDDHHSE---TLG------
prk-1_Cele ELEQEEIVETGETTNLMRSESRYDNISSSSFCDYVSLVSSSYDDQFTS---TSDIYQS--
Pim_Spur -------------------------------TG-HSMNSLDNSPYSSTNSSHEDIHKAQT
PIM3_Hsap ------------------------------------------------------------
PIM2_Hsap ------------------------------------------------------------
PIM1_Hsap ------------------------------------------------------------
PIM3_Mmus ------------------------------------------------------------
PIM2_Mmus ------------------------------------------------------------
PIM1_Mmus ------------------------------------------------------------
prk-2_Cele --------------DHSETEED--------------------------------------
prk-1_Cele ---------ACEVFPHTGSSSSLSRSMGAVKSASAYNLVRMRKKSSIFKSFDTELDPVSE
Pim_Spur CQCTVSHPSNC--FIHN--------------------------------------R--AS
PIM3_Hsap ------------------------------------------------------------
PIM2_Hsap ------------------------------------------------------------
PIM1_Hsap ------------------------------------------------------------
PIM3_Mmus ------------------------------------------------------------
PIM2_Mmus ------------------------------------------------------------
PIM1_Mmus ------------------------------------------------------------
prk-2_Cele -----RSPPT-SSV-SQQPGSADEGVGLS-------------------------------
prk-1_Cele NDHQPLIPET-SSATCQSTYSNDEDVTISEKVVSPAQPLPPPLSPRKGSLQCFESVPRSR
Pim_Spur DVVS----QTLSSV-KLLSNSQDSDSSDSGIED------------GE-------------
PIM3_Hsap ------------------------------TSSSESL
PIM2_Hsap ------------------------------LAWSLLP
PIM1_Hsap ------------------------------LSPGPSK
PIM3_Mmus ------------------------------TSSSESL
PIM2_Mmus ------------------------------LPWSLLP
PIM1_Mmus ------------------------------LSPGSSK
prk-2_Cele -----------------ASSSNT---VRIFIP-VVNM
prk-1_Cele DSVIRMSRHRPLQFAIDSSSPPPALAIFQVSPTASVG
Pim_Spur ------------------------VRDCLFVPIAQHS
.