Protein (view, download) , Domain (view, download)
MAP2K7_Hsap_MEK7                   LENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRS-GN--------KEENKRILMDLDVV
MAP2K6_Hsap_MEK3                   LEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VN--------SQEQKRLLMDLDIS
MAP2K5_Hsap_MEK5                   IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILL-DIT--------LELQKQIMSELEIL
MAP2K4_Hsap_MEK4                   LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRST-VD--------EKEQKQLLMDLDVV
MAP2K3_Hsap_MEK3                   LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT-VN--------SQEQKRLLMDLDIN
MAP2K2_Hsap_MEK1                   FERISELGAGNGGVVTKVQHRPSGLIMARKLIHL-EIK--------PAIRNQIIRELQVL
MAP2K1_Hsap_MEK1                   FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIK--------PAIRNQIIRELQVL
MAP2K7_Mmus_MEK7                   LENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRS-GN--------KEENKRILMDLDVV
MAP2K6_Mmus_MEK3                   LEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRAT-VN--------SQEQKRLLMDLDVS
MAP2K5_Mmus_MEK5                   IRYRDTLGHGNGGTVYKAHHVPSGKILAVKVILL-DIT--------LELQKQIMSELEIL
MAP2K4_Mmus_MEK4                   LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRST-VD--------EKEQKQLLMDLDVV
MAP2K3_Mmus_MEK3                   LVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRAT-VN--------TQEQKRLLMDLDIN
MAP2K2_Mmus_MEK1                   FERISELGAGNGGVVTKARHRPSGLIMARKLIHL-EIK--------PAVRNQIIRELQVL
MAP2K1_Mmus_MEK1                   FEKISELGAGNGGVVFKVSHKPSGLVMARKLIHL-EIK--------PAIRNQIIRELQVL
mkk-4_Cele_MEK4                    LQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCN-NIG-------HREQIRLLREHDTI
mek-2_Cele_MEK1                    lqtegelghgnggvvnkcvhrktgvimarklvhl-eik--------psvrqqivkelavl
mek-1_Cele_MEK7                    LQFVEDIGHGSCGTVTKCRYK--SVIMAVKTMPRT-SN--------SYEMSRILMDLDVI
jkk-1_Cele_MEK7                    IHIISLLGSGSCGVVESAT-----------TMYK-NDN--------KENLKRILRDVRIM
F35C8.2_Cele_STE7-Unclassified     LHGGVRIGSGEGQS-AVYRLIYNGMVIARKDVAVR-LPQGGDEDSTNKLMAKRLREVNVI
F35C8.1_Cele_STE7-Unclassified     LYGGERIGNGEGQS-AVYRLIYNGKLIARKDVAVR-LPKGVDQDSTNKLMAKKLREVNVI
E02D9.1_Cele_STE7-Unclassified     LQRGKYVGNGMHATVRMALHEKTQKWYVIKTILS-QNT-------DKT---EYEKEILAY
STE7_Scer_STE7-Unclassified        LVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPV-EQNN-------STIINQLVRELSIV
PBS2_Scer_STE7-Unclassified        LEFLDELGHGNYGNVSKVLHKPTNVIMATKEVRL-ELD--------EAKFRQILMELEVL
MKK2_Scer_STE7-Unclassified        ITTLGILGEGAGGSVAKCRLKNGKKVFALKTINTMNTD--------PEYQKQIFRELQFN
MKK1_Scer_STE7-Unclassified        IETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTD--------PEYQKQIFRELQFN
Dsor1_Dmel_MEK1                    LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHL-EVK--------PAIKKQILRELKVL
lic_Dmel_MEK3                      LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMT-VN--------IREQHRLVMDLDIS
Mkk4_Dmel_MEK4                     LEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRST-VD--------EKEQKQLLMDLEVV
hep_Dmel_MEK7                      LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRT-GN--------AEENKRILMDLDVV
sek-1_Cele_MEK3                    LVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSS-IN--------DQSQKQMLNELDAC
VZC374L.1_Cele_MEK4                LRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYN--N--------ICDQTRLLKEHDTH
ZC449.6_Cele_MEK4                  LQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLI-NNG-P-DDAFNKSMQRFRLEVEAT
Mek1_Ddis_STE7-Unclassified        LKIIRVLGRGAGGVVKLAYHETSGTYIALKVITL-DIQ--------ENIRKQIILELKTL
12278_Tthe_STE7-Unclassified       FETISELGRGASGRVFKVKHKETGKFYAKKEIRI-NDD--------EMFQKQLIWEIKTL
1557_Tthe_STE7-Unclassified        ------------------------------------------------------------
1909_Tthe_STE7-Unclassified        LRRVKVLGHGSSGLVELAVHDATGIVIGIKSIPL-LMN--------SSFRKQLDQELKTL
26687_Tthe_STE7-Unclassified       FEVVSELGKGAFGKVYKVCHKKDGKIYAMKEIIM-VDD--------IELRQKILMEVKTL
MEK_Spur_MEK1                      FEVLKELGAGNGGVVTKVKHKMSGMVMARKLIKL-EIK--------PAIRNQIIRELKVL
MEK3_Spur_MEK3                     MIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQ-VN--------STEDKRILMDMDVA
MKK4_Spur_MEK4                     LEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRST-VD--------EKDQKQLLMDLDVV
MKK5_Spur_MEK5                     ------------------------------------------------------------
MKK7_Spur_MEK7                     LESIGELGFGSCGHVIRMRHKESGTILAVKQMRRS-GN--------KEENKRILMDLDVV
CC1G_02205_Ccin_MEK1               LKKLSDLGQGNGGSVEKVEHLPTGTIMAKKSVLI-DAK--------SSVRKQILRELDIM
CC1G_03368_Ccin_MEK1               LVDIHDLGQGNGGSVKKVEHTPTKMIMAKKTVLI-DAK--------PSVRKQILRELHIM
CC1G_01983_Ccin_STE7-Unclassified  FEEISRLGEGAGGAVHKVKDKRNGMIMARKTIT-T--R--------EAPMKQLLRELTIM
CC1G_14241_Ccin_STE7-Unclassified  QLDDEELGRGNYGTVKKVLHKPTNVAMAMKEIRD-SIQ---------ANSPAIIMELDVL
AqueK243_Aque_MEK1                 FERLSELGHGNGGVVLKVMHKPSGIIMARKMILL-DIK--------PTVRNQIMRELKVL
AqueK244_Aque_MEK4                 ---VSEIGRGQFGQVNKMTHMVTGKVMAVKRIRVT-PD--------QAKSKSLLMEWKVP
AqueK245_Aque_MEK4                 LDVEEELGRGQYGQVNRMKHKPTGKIMAVKRIRAT-PD--------QAENKRLLMDYNVA
AqueK246_Aque_MEK4                 LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMK-DL---------RTSGGNVLELDVI
AqueK247_Aque_MEK5                 ------------------------------------------------------------
AqueK248_Aque_MEK7                 MLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDT--------WEEQRRVLMDLEVM
STE7-p1-1_Smoe_STE7-plant1         ------IGWGASSVVRKAIHIPTHRILALKKINV-FE---------KEKRQQLLNEIRTL
STE7-p1-2_Smoe_STE7-plant1         ------IGWGASSVVRKAIHIPTHRILALKKINV-FE---------KEKRQQLLNEIRTL
STE7-p2-2_Smoe_STE7-plant2         LEAVKVIGKGSSGVVQLVRHKWTGQVFALKAIQM-NIQ--------ETMRKQIVQEIKIN
STE7-p2-1_Smoe_STE7-plant2         LEAVKVIGKGSSGVVQLVRHKWTGQVFALKAIQM-NIQ--------ETMRKQIVQEIKIN
GK083_Glam_MEK1                    LEVVKPLGAGAFGTVNLVKVKTTGQLCAMKEIRI-SDE--------EQTQKNIYREIKAS


MAP2K7_Hsap_MEK7                   LKSHDCPYIVQCFGTFITNT----DV-FIAMELMGT-CAEKLKKR---------------
MAP2K6_Hsap_MEK3                   MRTVDCPFTVTFYGALFREG----DV-WICMELMDT-SLDKFYKQVID------------
MAP2K5_Hsap_MEK5                   YKC-DSSYIIGFYGAFFVE----NRI-SICTEFMDGGSLDVY------------------
MAP2K4_Hsap_MEK4                   MRSSDCPYIVQFYGALFREG----DC-WICMELMST-SFDKFYKYVYS------------
MAP2K3_Hsap_MEK3                   MRTVDCFYTVTFYGALFREG----DV-WICMELMDT-SLDKFYRKVLD------------
MAP2K2_Hsap_MEK1                   HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKE---------------
MAP2K1_Hsap_MEK1                   HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKK---------------
MAP2K7_Mmus_MEK7                   LKSHDCPYIVQCFGTFITNT----DV-FIAMELMGT-CAEKLKKR---------------
MAP2K6_Mmus_MEK3                   MRTVDCPFTVTFYGALFREG----DV-WICMELMDT-SLDKFYKQVID------------
MAP2K5_Mmus_MEK5                   YKC-DSSYIIGFYGAFFVE----NRI-SICTEFMDGGSLDVY------------------
MAP2K4_Mmus_MEK4                   MRSSDCPYIVQFYGALFREG----DC-WICMELMST-SFDKFYKYVYS------------
MAP2K3_Mmus_MEK3                   MRTVDCFYTVTFYGALFREG----DV-WICMELMDT-SLDKFYRKVLE------------
MAP2K2_Mmus_MEK1                   HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKE---------------
MAP2K1_Mmus_MEK1                   HEC-NSPYIVGFYGAFYSD----GEI-SICMEHMDGGSLDQVLKK---------------
mkk-4_Cele_MEK4                    VKSEKGPNIVKFYGAIFSEG----DC-WICMELMDI-SMDLLYKRVYM------------
mek-2_Cele_MEK1                    hkc-nspfivgfygafvdn----ndi-sicmeymdglsldivlkk---------------
mek-1_Cele_MEK7                    CLSFDCPYIVRCFGYFITNF----DV-RVCMECMAT-CLDRLLIR---------------
jkk-1_Cele_MEK7                    -SMCNSPFIVTSYGYFMFDS----SV-KICMQIMSA-CCEKLLRRIYH------------
F35C8.2_Cele_STE7-Unclassified     NGCAPCPFIVHFFGYYVHKYKDCVKI-HIFMEEMAL-SASVLKKEVLK------------
F35C8.1_Cele_STE7-Unclassified     NGCAPCPFIVHFFGYYVHKYRDCVKI-HIFMEEMAL-SASVLKTEALK------------
E02D9.1_Cele_STE7-Unclassified     EECSQSDYVVGYHGCEVSS----IKK-ELVLEYMDKGDFR--------------------
STE7_Scer_STE7-Unclassified        KNVKPHENIITFYGAYYNQHIN-NEI-IILMEYSDCGSLDKILSVYKRFVQRG-------
PBS2_Scer_STE7-Unclassified        HKC-NSPYIVDFYGAFFIE----GAV-YMCMEYMDGGSLDKIYDESS-------------
MKK2_Scer_STE7-Unclassified        KSF-KSDYIVQYYGMFTDEQ-S-SSI-YIAMEYMGGKSLEATYKNLL-------------
MKK1_Scer_STE7-Unclassified        RSF-QSEYIVRYYGMFTDDE-N-SSI-YIAMEYMGGRSLDAIYKNLL-------------
Dsor1_Dmel_MEK1                    HEC-NFPHIVGFYGAFYSD----GEI-SICMEYMDGGSLDLILKR---------------
lic_Dmel_MEK3                      MRSSDCPYTVHFYGAMYREG----DV-WICMEVMST-SLDKFYPKVFL------------
Mkk4_Dmel_MEK4                     MKSNECIYIVQFYGALFKEG----DC-WICMELMDT-SLDKFYKYIYE------------
hep_Dmel_MEK7                      LKSHDCKYIVKCLGCFVRDP----DV-WICMELMSM-CFDKLLKL---------------
sek-1_Cele_MEK3                    RRSDCCPQMVRFYGAMFREG----DV-WICMEVMDT-SLDKFYRHAYK------------
VZC374L.1_Cele_MEK4                MKSENVPNIVKFFGACFSEG----DC-WICMELMDI-SIDFLYKRVYS------------
ZC449.6_Cele_MEK4                  KAASNCDEIVRYYGITFNEG----VA-WMCMELMDL-SLDKLYMIAHD------------
Mek1_Ddis_STE7-Unclassified        HK-TSYPYIVSFYDAFYTE----GSI-FIALEFMELGSLSDIMKK---------------
12278_Tthe_STE7-Unclassified       FS-CNSPHIVQYYCAFYTE----CML-HLILEYMDMGTLDTILKKT--------------
1557_Tthe_STE7-Unclassified        -----HPNLITCFGAYYEE----GTI-KIILELMDFGSIRNLIDML--------------
1909_Tthe_STE7-Unclassified        IQ-CESDSIVKCYGAYIQK----CMI-NITLEYMDLGTVHDLVKK---------------
26687_Tthe_STE7-Unclassified       FI-CQSPYIVTYYGAFYTE----GKL-HIILEYMDVGTLDSLLKKA--------------
MEK_Spur_MEK1                      HEC-NSPYIVGFFGAYYSD----GEI-CICMENMDGGSLDQVMKSA--------------
MEK3_Spur_MEK3                     MRSSDCVYTVEFYGALFQEG----DV-WICMEVMDT-CLDKLYKNKLK------------
MKK4_Spur_MEK4                     KRSANCVYIIKFFGALFKEG----DC-WICMELMDS-SLDKFYRFVHE------------
MKK5_Spur_MEK5                     -KC-DSPFIIGFYGAFFTE----NRI-SICTEFMDGGSLEMY------------------
MKK7_Spur_MEK7                     LKSHNCPFIVQCLGAIVTPS----EV-WICMEQMAT-CLDKLIKK---------------
CC1G_02205_Ccin_MEK1               HEC-QSDYIISCFGSFLAE----PNI-CICMEFMDKGSFDGIYKK---------------
CC1G_03368_Ccin_MEK1               HDC-RSDYIISFYGAFLAD----NNI-CICMEFMDKGSLDGIYKK---------------
CC1G_01983_Ccin_STE7-Unclassified  SST-KHVNIITFYGAYMSPS-S-SEI-KIIMEYCEGGSLESVGKRIR-------------
CC1G_14241_Ccin_STE7-Unclassified  HRA-VAPEIVEFYGAFFIE----SCV-YYCMEYMDAGSLDKLIQSNSQPPQPQIPKPPSS
AqueK243_Aque_MEK1                 HDC-NASYIVGFFGSFHVN----NEI-SILMQHMDGGSLDLVL-N---------------
AqueK244_Aque_MEK4                 KNSVECPYTILFYGAFFCEN----DV-WICMELMDR-SLEELYHLVYD------------
AqueK245_Aque_MEK4                 MRSIDCPFTITFYGALFREG----DV-WICMELMDK-SLDKLYQLVYK------------
AqueK246_Aque_MEK4                 KKVKECPFIVHFYGCLLREG----HV-WICMELLDS-SMAQVSEIVYN------------
AqueK247_Aque_MEK5                 ----DSQYIIGFYGSFFQE----NRI-SICTEYMDGGSLDQY------------------
AqueK248_Aque_MEK7                 -NSQHSPFIVEYYGSAIVKN----EV-WVFMELMAT-CLDRLLKR---------------
STE7-p1-1_Smoe_STE7-plant1         CEAPMAKGLVEFYGAFYSPD-S-GQI-SIALEYMDGGSLADIVRN---------------
STE7-p1-2_Smoe_STE7-plant1         CEAPMAKGLVEFYGAFYSPD-S-GQI-SIALEYMDGGSLADIVRN---------------
STE7-p2-2_Smoe_STE7-plant2         QS-SQCPYVVVCYEAFYNN----GVI-SIVFEYMDGGSLLDVIKE---------------
STE7-p2-1_Smoe_STE7-plant2         QS-SQCPYVVVCYEAFYNN----GVI-SIVFEYMDGGSLLDVIKE---------------
GK083_Glam_MEK1                    ISLSCNPYMVKTYNIYSHP----GSILHILLEFCKYGSSQDMLKKL--------------
                                            :                     :

MAP2K7_Hsap_MEK7                   --------------------------------------------------MQGPIPERIL
MAP2K6_Hsap_MEK3                   --------------------------------------------------KGQTIPEDIL
MAP2K5_Hsap_MEK5                   ----------------------------------------------------RKMPEHVL
MAP2K4_Hsap_MEK4                   -------------------------------------------------VLDDVIPEEIL
MAP2K3_Hsap_MEK3                   --------------------------------------------------KNMTIPEDIL
MAP2K2_Hsap_MEK1                   ---------------------------------------------------AKRIPEEIL
MAP2K1_Hsap_MEK1                   ---------------------------------------------------AGRIPEQIL
MAP2K7_Mmus_MEK7                   --------------------------------------------------MQGPIPERIL
MAP2K6_Mmus_MEK3                   --------------------------------------------------KGQTIPEDIL
MAP2K5_Mmus_MEK5                   ----------------------------------------------------RKIPEHVL
MAP2K4_Mmus_MEK4                   -------------------------------------------------VLDDVIPEEIL
MAP2K3_Mmus_MEK3                   --------------------------------------------------KNMKIPEDIL
MAP2K2_Mmus_MEK1                   ---------------------------------------------------AKRIPEDIL
MAP2K1_Mmus_MEK1                   ---------------------------------------------------AGRIPEQIL
mkk-4_Cele_MEK4                    -------------------------------------------------VKNSRLNENVV
mek-2_Cele_MEK1                    ---------------------------------------------------vgrlpekfv
mek-1_Cele_MEK7                    --------------------------------------------------IKQPIPERII
jkk-1_Cele_MEK7                    -------------------------------------------------SKLDFFPEFVA
F35C8.2_Cele_STE7-Unclassified     --------------------------------------------------RGGIVPEFVI
F35C8.1_Cele_STE7-Unclassified     --------------------------------------------------QGGAIPEFVI
E02D9.1_Cele_STE7-Unclassified     --------------------------------------------------PFGILPFSVH
STE7_Scer_STE7-Unclassified        ----------------------------------------------TVSSKKTWFNELTI
PBS2_Scer_STE7-Unclassified        --------------------------------------------------EIGGIDEPQL
MKK2_Scer_STE7-Unclassified        -------------------------------------------------KRGGRISERVI
MKK1_Scer_STE7-Unclassified        -------------------------------------------------ERGGRISEKVL
Dsor1_Dmel_MEK1                    ---------------------------------------------------AGRIPESIL
lic_Dmel_MEK3                      --------------------------------------------------HDLRMEESVL
Mkk4_Dmel_MEK4                     -------------------------------------------------KQQRHIPESIL
hep_Dmel_MEK7                      --------------------------------------------------SKKPVPEQIL
sek-1_Cele_MEK3                    --------------------------------------------------IGKHIPEPFI
VZC374L.1_Cele_MEK4                -------------------------------------------------VKKSRLNENII
ZC449.6_Cele_MEK4                  -------------------------------------------------IQKVEIPEQIL
Mek1_Ddis_STE7-Unclassified        ---------------------------------------------------TSTIPEPVL
12278_Tthe_STE7-Unclassified       ----------------------------------------------------KQVSEPIL
1557_Tthe_STE7-Unclassified        ----------------------------------------------------KEINYCYL
1909_Tthe_STE7-Unclassified        ---------------------------------------------------VGPLPEIIV
26687_Tthe_STE7-Unclassified       ---------------------------------------------------GGKVSEVVL
MEK_Spur_MEK1                      --------------------------------------------------PKGRIPENIL
MEK3_Spur_MEK3                     -------------------------------------------------PQKIFVPENIL
MKK4_Spur_MEK4                     -------------------------------------------------VQNTYIPENIM
MKK5_Spur_MEK5                     ----------------------------------------------------RCIPESIL
MKK7_Spur_MEK7                     --------------------------------------------------LREPVPEQII
CC1G_02205_Ccin_MEK1               ---------------------------------------------------LGPLQVEVV
CC1G_03368_Ccin_MEK1               ---------------------------------------------------IGAIDIDIV
CC1G_01983_Ccin_STE7-Unclassified  -------------------------------------------------ERGAIVGEKIA
CC1G_14241_Ccin_STE7-Unclassified  DPIQTDASSPEYSFAMPFVEEDLDLTKDENFEPYNRAFNRTCPPPIPSTYSGGPIPEAIL
AqueK243_Aque_MEK1                 ---------------------------------------------------TGRIPVDMI
AqueK244_Aque_MEK4                 -------------------------------------------------KLKESIP----
AqueK245_Aque_MEK4                 -------------------------------------------------KLNEKIPEVIV
AqueK246_Aque_MEK4                 -------------------------------------------------KMNERIPEDIL
AqueK247_Aque_MEK5                 ----------------------------------------------------APLSETVL
AqueK248_Aque_MEK7                 --------------------------------------------------LKGPIPERII
STE7-p1-1_Smoe_STE7-plant1         ---------------------------------------------------KKFIPEPIL
STE7-p1-2_Smoe_STE7-plant1         ---------------------------------------------------KKFIPEPIL
STE7-p2-2_Smoe_STE7-plant2         ---------------------------------------------------VNALPEPYL
STE7-p2-1_Smoe_STE7-plant2         ---------------------------------------------------VNALPEPYL
GK083_Glam_MEK1                    --------------------------------------------------KTGKLTENAL
                                                                                         .

MAP2K7_Hsap_MEK7                   GK------------MTVAIVKALYYLKE-KHGVIHRDVKPSNILLD-ERGQIKLCDFGIS
MAP2K6_Hsap_MEK3                   GK------------IAVSIVKALEHLHS-KLSVIHRDVKPSNVLIN-ALGQVKMCDFGIS
MAP2K5_Hsap_MEK5                   GR------------IAVAVVKGLTYLWS--LKILHRDVKPSNMLVN-TRGQVKLCDFGVS
MAP2K4_Hsap_MEK4                   GK------------ITLATVKALNHLKE-NLKIIHRDIKPSNILLD-RSGNIKLCDFGIS
MAP2K3_Hsap_MEK3                   GE------------IAVSIVRALEHLHS-KLSVIHRDVKPSNVLIN-KEGHVKMCDFGIS
MAP2K2_Hsap_MEK1                   GK------------VSIAVLRGLAYLRE-KHQIMHRDVKPSNILVN-SRGEIKLCDFGVS
MAP2K1_Hsap_MEK1                   GK------------VSIAVIKGLTYLRE-KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS
MAP2K7_Mmus_MEK7                   GK------------MTVAIVKALYYLKE-KHGVIHRDVKPSNILLD-ERGQIKLCDFGIS
MAP2K6_Mmus_MEK3                   GK------------IAVSIVKALEHLHS-KLSVIHRDVKPSNVLIN-TLGQVKMCDFGIS
MAP2K5_Mmus_MEK5                   GR------------IAVAVVKGLTYLWS--LKILHRDVKPSNMLVN-TGGQVKLCDFGVS
MAP2K4_Mmus_MEK4                   GK------------ITLATVKALNHLKE-NLKIIHRDIKPSNILLD-RSGNIKLCDFGIS
MAP2K3_Mmus_MEK3                   GE------------IAVSIVRALEHLHS-KLSVIHRDVKPSNVLIN-KEGHVKMCDFGIS
MAP2K2_Mmus_MEK1                   GK------------VSIAVLRGLAYLRE-KHQIMHRDVKPSNILVN-SRGEIKLCDFGVS
MAP2K1_Mmus_MEK1                   GK------------VSIAVIKGLTYLRE-KHKIMHRDVKPSNILVN-SRGEIKLCDFGVS
mkk-4_Cele_MEK4                    GH------------ITVCTVDALDYLKK-ELKIIHRDVKPSNILVD-GTGAVKLCDFGIC
mek-2_Cele_MEK1                    gr------------isvavvrgltylkd-eikilhrdvkpsnmlvn-sngeiklcdfgvs
mek-1_Cele_MEK7                    GK------------LSVSIIKALHYLKT-KHQIMHRDVKPSNILLD-WSGVIKLCDFGIA
jkk-1_Cele_MEK7                    GH------------IVYSAISALDYLKE-KHSIIHRDIKPSNILFD-DSGNVKLCDFGIS
F35C8.2_Cele_STE7-Unclassified     GR------------IACSVIHAMWFLKE-KMQIIHRDIKPGNILID-YDGRVKICDFGIS
F35C8.1_Cele_STE7-Unclassified     GR------------IVCSVIHAMWFLKD-RLQIIHRDIKPGNILID-YDGRVKICDFGIC
E02D9.1_Cele_STE7-Unclassified     QS------------VALSLIRAIRHVWNSGPGYIHRDIKPENILVN-SQGYVKICDFGAA
STE7_Scer_STE7-Unclassified        SK------------IAYGVLNGLDHLYR-QYKIIHRDIKPSNVLIN-SKGQIKLCDFGVS
PBS2_Scer_STE7-Unclassified        AF------------IANAVIHGLKELKE-QHNIIHRDVKPTNILCSANQGTVKLCDFGVS
MKK2_Scer_STE7-Unclassified        GK------------IAESVLRGLSYLHE-R-KVIHRDIKPQNILLN-EKGEIKLCDFGVS
MKK1_Scer_STE7-Unclassified        GK------------IAEAVLRGLSYLHE-K-KVIHRDIKPQNILLN-ENGQVKLCDFGVS
Dsor1_Dmel_MEK1                    GR------------ITLAVLKGLSYLRD-NHAIIHRDVKPSNILVN-SSGEIKICDFGVS
lic_Dmel_MEK3                      GK------------IAMSVVSALHYLHA-QLKVIHRDVKPSNILIN-RAGQVKICDFGIS
Mkk4_Dmel_MEK4                     AK------------ITVATVNALNYLKE-ELKIIHRDVKPSNILLH-RRGDIKLCDFGIS
hep_Dmel_MEK7                      GK------------VTVATVNALSYLKD-KHGVIHRDVKPSNILID-ERGNIKLCDFGIS
sek-1_Cele_MEK3                    GK------------MALSVIEGLNFMKE-QLNLIHRDVKPSNILLN-RHGQVKICDFGIS
VZC374L.1_Cele_MEK4                GH------------ITVCIVDALDYLKR-KLNRIHRDVKPSNILIN-AAGDVKLCDFGIC
ZC449.6_Cele_MEK4                  GA------------VAVATIRALEHLKT-THHIIHRDIKPSNILLD-RHGCVKLCDFGIC
Mek1_Ddis_STE7-Unclassified        GK------------IAFQVLQGLVYLHR-KLHLIHRDIKPSNILVN-NKGEAKIADFGVS
12278_Tthe_STE7-Unclassified       IY------------TTYQIIKGIHYLHK-DLKIIHRDLKPGNILVN-SEGEIKISDLGIC
1557_Tthe_STE7-Unclassified        SKILCNQKYQYHFFILKQLLKGLEFLHK-ERHQVHRDIKPENILIN-KRGNVKLTDFGIS
1909_Tthe_STE7-Unclassified        AI------------MAIQVLKGLDYIHN-KAKVIHRDIKPSNLLVN-SKGQVKIADFGVS
26687_Tthe_STE7-Unclassified       KY------------LTYQILKGLKYLHK-DLHIIHRDIKPGNILVN-SKGEIKISDLGIC
MEK_Spur_MEK1                      GK------------VTVAVLRGLIYLRD-VHDIMHRDVKPSNILVN-SRGEIKLCDFGVS
MEK3_Spur_MEK3                     SR------------ISFSIVSALKYLQT-RLKVIHRDVKPSNVLAN-HNGKIKLCDFGIS
MKK4_Spur_MEK4                     GK------------VAYATVKALNYLKE-TLKIIHRDVKPSNILLD-RGGNIKLCDFGIS
MKK5_Spur_MEK5                     GR------------MTVSIVKGLNYLWN--LKIMHRDVKPSNILVN-TQGEIKLCDFGVS
MKK7_Spur_MEK7                     GK------------MVVAIVNALNYLKE-KHGVMHRDVKPSNMLLD-EKGVVKLCDFGIS
CC1G_02205_Ccin_MEK1               GM------------VALSVLEGLTYLYD-VHRIMHRDIKPSNILFN-SQGQIKLCDFGVS
CC1G_03368_Ccin_MEK1               GK------------IALAVLEGLTYLYD-VHRIIHRDIKPSNILCN-SRGQIKICDFGVS
CC1G_01983_Ccin_STE7-Unclassified  GR------------LAEGVLQGLSYLHS-K-KTIHRDIKPSNILLS-KEGVVKLCDFGVS
CC1G_14241_Ccin_STE7-Unclassified  GR------------IAASMVRGLKFLKD-ELNIIHRDVKPTNVLVN-CKGQVKLCDFGVS
AqueK243_Aque_MEK1                 GQ------------ITVAVLNGLKYLRD-THHIIHRDVKPSNILVN-SEGEIKLCDFGVS
AqueK244_Aque_MEK4                 ----------------ELTLKALTYLHD-KLNVMHRDVKPSNILIN-QNGEIKLCDFGIA
AqueK245_Aque_MEK4                 GK------------MADSTLKALTYLHD-ELQVMHRDVKPSNILIN-KKGEIKLCDFGIA
AqueK246_Aque_MEK4                 GK------------MTVAVINALHFLQK-ELKIIHRDVKPSNILVS-KVGEFKLCDFGIS
AqueK247_Aque_MEK5                 SK------------ITAAILKGLNYLWS--IKVLHRDIKPSNMLVN-THGQIKLCDFGVS
AqueK248_Aque_MEK7                 GK------------MCVSIVKALDYLKR-AHKVIHRDVKPSNILID-VNGNVKLCDFGIS
STE7-p1-1_Smoe_STE7-plant1         SV------------ITRKVLQGLQFLHG-VRHLVHRDIKPANLLIN-LIGEPKITDFGIS
STE7-p1-2_Smoe_STE7-plant1         SV------------ITRKVLQGLQFLHG-VRHLVHRDIKPANLLIN-LIGEPKITDFGIS
STE7-p2-2_Smoe_STE7-plant2         AA------------ICKQVLKGLVYLHL-DRRIIHRDIKPSNLLVN-HKGEVKITDFGVS
STE7-p2-1_Smoe_STE7-plant2         AA------------ICKQVLKGLVYLHL-DRRIIHRDIKPSNLLVN-HKGEVKITDFGVS
GK083_Glam_MEK1                    AV------------FIIDTLRGLAYLHD-NCKIIHRDIKSANILID-EHGYCKLADFGVA
                                                      : .:  :       :***:*. *:*     *  *: *:* .

MAP2K7_Hsap_MEK7                   GRLVD---SKAKT-RSAGCAAYMAPERIDPPDP---------------------------
MAP2K6_Hsap_MEK3                   GYLVD---SVAKT-IDAGCKPYMAPERINPEL----------------------------
MAP2K5_Hsap_MEK5                   TQLVN---SIAKT--YVGTNAYMAPERIS-------------------------------
MAP2K4_Hsap_MEK4                   GQLVD---SIAKT-RDAGCRPYMAPERIDPSA----------------------------
MAP2K3_Hsap_MEK3                   GYLVD---SVAKT-MDAGCKPYMAPERINPEL----------------------------
MAP2K2_Hsap_MEK1                   GQLID---SMANS--FVGTRSYMAPERLQ-------------------------------
MAP2K1_Hsap_MEK1                   GQLID---SMANS--FVGTRSYMSPERLQ-------------------------------
MAP2K7_Mmus_MEK7                   GRLVD---SKAKT-RSAGCAAYMAPERIDPPDP---------------------------
MAP2K6_Mmus_MEK3                   GYLVD---SVAKT-IDAGCKPYMAPERINPEL----------------------------
MAP2K5_Mmus_MEK5                   TQLVN---SIAKT--YVGTNAYMAPERIS-------------------------------
MAP2K4_Mmus_MEK4                   GQLVD---SIAKT-RDAGCRPYMAPERIDPSA----------------------------
MAP2K3_Mmus_MEK3                   GYLVD---SVAKT-MDAGCKPYMAPERINPEL----------------------------
MAP2K2_Mmus_MEK1                   GQLID---SMANS--FVGTRSYMSPERLQ-------------------------------
MAP2K1_Mmus_MEK1                   GQLID---SMANS--FVGTRSYMSPERLQ-------------------------------
mkk-4_Cele_MEK4                    GQLEE---SFAKT-HDAGCQPYLAPERITS------------------------------
mek-2_Cele_MEK1                    gmlid---smans--fvgtrsymaperlt-------------------------------
mek-1_Cele_MEK7                    GRLIE---SRAHS-KQAGCPLYMGPERLDPN-----------------------------
jkk-1_Cele_MEK7                    GFMTD---SMAHS-KSAGCPPYMAPERLTIE-----------------------------
F35C8.2_Cele_STE7-Unclassified     GILQD---SIAVS--ATGCQQYTAPEINELAMV---------------------------
F35C8.1_Cele_STE7-Unclassified     GILEN---SIAVS--DTGCQQYTAPEILVKGVS---------------------------
E02D9.1_Cele_STE7-Unclassified     KRIDN---TYRIASSAAGTQMYQAPEQQM-------------------------------
STE7_Scer_STE7-Unclassified        KKLIN---SIADT--FVGTSTYMSPERIQ-------------------------------
PBS2_Scer_STE7-Unclassified        GNLVA---SLAKT--NIGCQSYMAPERIKSLNP---------------------------
MKK2_Scer_STE7-Unclassified        GEAVN---SLAMT--FTGTSFYMAPERIQ-------------------------------
MKK1_Scer_STE7-Unclassified        GEAVN---SLATT--FTGTSFYMAPERIQ-------------------------------
Dsor1_Dmel_MEK1                    GQLID---SMANS--FVGTRSYMSPERLQ-------------------------------
lic_Dmel_MEK3                      GYLVD---SIAKT-IDAGCKPYMAPERIDPQG----------------------------
Mkk4_Dmel_MEK4                     GQLVD---SIAKT-KDAGCRPYMAPERIDPE-----------------------------
hep_Dmel_MEK7                      GRLVD---SKANT-RSAGCAAYMAPERIDPK-----------------------------
sek-1_Cele_MEK3                    GHLTN---SMAKT-VQAGCKPYMPPERIDGE-----------------------------
VZC374L.1_Cele_MEK4                GDLVG---SYAIT-VEAGCVQYLAPERIEN------------------------------
ZC449.6_Cele_MEK4                  GYLQN---SVAQS-VDVGCRPYMAPERLAP------------------------------
Mek1_Ddis_STE7-Unclassified        GQLQH---TLSKAVTWVGTVTYMSPERIS-------------------------------
12278_Tthe_STE7-Unclassified       GKVNG---TMDQKNTFVGTTIYMSPERLN-------------------------------
1557_Tthe_STE7-Unclassified        KQLEK---TQQLCMTYVGTTLYMSPERLI-------------------------------
1909_Tthe_STE7-Unclassified        ANLES---AVEV-KNWVGTVTYMSPERFR-------------------------------
26687_Tthe_STE7-Unclassified       GAINA---TLDERQTFVGTSIYMSPERLS-------------------------------
MEK_Spur_MEK1                      GQLID---SMANS--FVGTRSYMSPERLQ-------------------------------
MEK3_Spur_MEK3                     GQLVN---SMAKT-QDAGSRQYMAPERIDPDM----------------------------
MKK4_Spur_MEK4                     GQLVD---SIART-MDAGCKPYMAPERIDPFQ----------------------------
MKK5_Spur_MEK5                     AQLVS---SITRT--YIGTNAYMAPERVL-------------------------------
MKK7_Spur_MEK7                     GRLVD---SKART-RSAGCAAYMAPERIDPPDP---------------------------
CC1G_02205_Ccin_MEK1               GEVIN---SIANT--FVGTSVYMSPERIQSH-----------------------------
CC1G_03368_Ccin_MEK1               GELIN---SIADT--FVGTSTYMSPERIQ-------------------------------
CC1G_01983_Ccin_STE7-Unclassified  GELIL---SQAGT--FTGTSFYMAPERIQ-------------------------------
CC1G_14241_Ccin_STE7-Unclassified  GQLDK---SMAKT--NIGCQSYMAPERIRGESRVVGAVPASEGGTGTAAAAQGGVPGTAA
AqueK243_Aque_MEK1                 GQLIN---SMANS--FVGTRSYMAPERLQ-------------------------------
AqueK244_Aque_MEK4                 GELVD---SLAKT--DIGCRPYLAPERIDEP-----------------------------
AqueK245_Aque_MEK4                 GELVN---SLAKT--DIGCRPYLAPERIYGG-----------------------------
AqueK246_Aque_MEK4                 GKLVD---SIART-MDVGCRPYMAPERIDPAR----------------------------
AqueK247_Aque_MEK5                 VQLMT---SLTKT--YIGTNAYMAPERIL-------------------------------
AqueK248_Aque_MEK7                 GRLVD---SKAFT-RGAGAAAYMAPERINMSH----------------------------
STE7-p1-1_Smoe_STE7-plant1         AGLDN---SIAMCATFVGTVTYMSPERIN-------------------------------
STE7-p1-2_Smoe_STE7-plant1         AGLDN---SIAMCATFVGTVTYMSPERIN-------------------------------
STE7-p2-2_Smoe_STE7-plant2         AVLAN---SMGQRDTFVGTYTYMSPERIS-------------------------------
STE7-p2-1_Smoe_STE7-plant2         AVLAN---SMGQRDTFVGTYTYMSPERIS-------------------------------
GK083_Glam_MEK1                    SSVLPNDDEAAM-KTFVGSLSYMSPERIQ-------------------------------
                                                    *   *  **

MAP2K7_Hsap_MEK7                   ----TKPDYDIRADVWSLGISLPCPSPSQVELATGQFPYKN-------------------
MAP2K6_Hsap_MEK3                   ----NQKGYSVKSDIWSLGITM-------IELAILRFPYDS-------------------
MAP2K5_Hsap_MEK5                   -----GEQYGIHSDVWSLGISF-------MELALGRFPYPQIQKN---------------
MAP2K4_Hsap_MEK4                   ----SRQGYDVRSDVWSLGITL-------YELATGRFPYPK-------------------
MAP2K3_Hsap_MEK3                   ----NQKGYNVKSDVWSLGITM-------IEMAILRFPYES-------------------
MAP2K2_Hsap_MEK1                   -----GTHYSVQSDIWSMGLSL-------VELAVGRYPIPPPDAKELEAIFGRPVVDGEE
MAP2K1_Hsap_MEK1                   -----GTHYSVQSDIWSMGLSL-------VEMAVGRYPIPPPDAKELELMFGCQV----E
MAP2K7_Mmus_MEK7                   ----TKPDYDIRADVWSLGISLQCLSPSQVELATGQFPYKN-------------------
MAP2K6_Mmus_MEK3                   ----NQKGYSVKSDIWSLGITM-------IELAILRFPYDS-------------------
MAP2K5_Mmus_MEK5                   -----GEQYGIHSDVWSLGISF-------MELALGRFPYPQIQKN---------------
MAP2K4_Mmus_MEK4                   ----SRQGYDVRSDVWSLGITL-------YELATGRFPYPK-------------------
MAP2K3_Mmus_MEK3                   ----NQKGYNVKSDVWSLGITM-------IEMAILRFPYES-------------------
MAP2K2_Mmus_MEK1                   -----GTHYSVQSDIWSMGLSL-------VELAIGRYPIPPPDAKELEASFGRPVVDGAD
MAP2K1_Mmus_MEK1                   -----GTHYSVQSDIWSMGLSL-------VEMAVGRYPIPPPDAKELELLFGCHV----E
mkk-4_Cele_MEK4                    -----SDKYDVRSDVWSLGITL-------YEIATGKFPYQEWN-----------------
mek-2_Cele_MEK1                    -----gshytissdiwsfglsl-------velligrypvpapsqaeyatmfnvae---ne
mek-1_Cele_MEK7                    ----NFDSYDIRSDVWSFGVTL-------VELATGQYPYAG-------------------
jkk-1_Cele_MEK7                    ----TNSKYDVRSDVWSLGITV-------YQLVTGLYPFPL-------------------
F35C8.2_Cele_STE7-Unclassified     ----HSPGYSIKSDIWSLGITI-------FELATL-------------------------
F35C8.1_Cele_STE7-Unclassified     ----NSPGYSIKSDIWSLGITI-------FELATLRYPYPV-------------------
E02D9.1_Cele_STE7-Unclassified     -----GQDYSEKVDIWCFGLTL-------WEFAIGPNLEEYLN-----------------
STE7_Scer_STE7-Unclassified        -----GNVYSIKGDVWSLGLMI-------IELVTGEFPLGGHNDT---------------
PBS2_Scer_STE7-Unclassified        ----DRATYTVQSDIWSLGLSI-------LEMALGRYPYPPET-----------------
MKK2_Scer_STE7-Unclassified        -----GQPYSVTCDVWSLGLTL-------LEVAGGRFPFESDKIT---------------
MKK1_Scer_STE7-Unclassified        -----GQPYSVTSDVWSLGLTI-------LEVANGKFPCSSEKMA---------------
Dsor1_Dmel_MEK1                    -----GTHYSVQSDIWSLGLSL-------VEMAIGMYPIPPPNTATLESIFADNAE--ES
lic_Dmel_MEK3                      ----NPAQYDIRSDVWSLGIGM-------IEMATGRYPYDN-------------------
Mkk4_Dmel_MEK4                     ----RAKGYDVRSDVWSLGITL-------MEVATGNFPYRK-------------------
hep_Dmel_MEK7                      -----KPKYDIRADVWSLGITL-------VELATARSPYEG-------------------
sek-1_Cele_MEK3                    ----TKSAYDVRADVWSLGITI-------IEIAVGTHPYAN-------------------
VZC374L.1_Cele_MEK4                -----MDKYDIRSDVWSLGITL-------YEIATGVYPYRGWS-----------------
ZC449.6_Cele_MEK4                  ----NGDGYDIKSEVWSLGITM-------VEVANGKYPYDGFM-----------------
Mek1_Ddis_STE7-Unclassified        -----GRSYSFDSEIWSLGLTI-------LECAIGKFPYGSNLPHQQQQPLQQQQQ--QQ
12278_Tthe_STE7-Unclassified       -----GDSYTMKTDIWSVGLLL-------IEFSEGKHPIQA-------------------
1557_Tthe_STE7-Unclassified        -----GNQYGLRSDIWSVGLVI-------IELATGLYPYDVKN-----------------
1909_Tthe_STE7-Unclassified        -----GQAYTANTDIWSLGLTI-------CECALGTYPYFDSNQYEKK------------
26687_Tthe_STE7-Unclassified       -----GESYSVKTDIWSFGLLL-------LEFSESKNPLQLNE-----------------
MEK_Spur_MEK1                      -----GTHYTVQSDIWSLGLSL-------VEMAIGRYPIPAPDETALANLFGYEL---QA
MEK3_Spur_MEK3                     ----SAKGYDVKSDVWSFGITM-------IEIATNAYPYER-------------------
MKK4_Spur_MEK4                     ----SRPGYDIRSDVWSLGITM-------YEVATGEFPYPK-------------------
MKK5_Spur_MEK5                     -----GDEYGVHSEVWSLGVFL-------LEMATGRFPYPATPRD---------------
MKK7_Spur_MEK7                     ----NNPDYDVRADVWSLG-----------------------------------------
CC1G_02205_Ccin_MEK1               -----GDGYSVKSDVWSLGMSL-------VELALGAFPFTDPPDDD-DDDLSDLEG--DS
CC1G_03368_Ccin_MEK1               -----GAQYTVKSDVWSLGISL-------IELALGRFPFSQSDSDESDDEFSDASD--YE
CC1G_01983_Ccin_STE7-Unclassified  -----GKEYTIRSDVWSTGISL-------LELVQNRFPFPPDL-----------------
CC1G_14241_Ccin_STE7-Unclassified  LADELYGAYTVSSDVWSLGLSI-------IELGLGRYPYPPET-----------------
AqueK243_Aque_MEK1                 -----GEVYSVLSDIWSLGVSL-------IEMAIGSYPIPAPPKEQLDEEMRNPP----A
AqueK244_Aque_MEK4                 -----QHEYDHRSDVWSLGITM-------YEIAMGEFPYPVDT-----------------
AqueK245_Aque_MEK4                 -----QHKYDHRSDVWSLGITL-------CELATGEFPYPP-------------------
AqueK246_Aque_MEK4                 ----ACLGYTIQSDVWSYGITL-------VELAQGSFPYKKWN-----------------
AqueK247_Aque_MEK5                 -----GGEYGVHSEIWSLGLSL-------MELSLGYFP----------------------
AqueK248_Aque_MEK7                 ----DSKGYDVRADVWSLGISL-------VEMATGSAPYKFNE-----------------
STE7-p1-1_Smoe_STE7-plant1         -----NECYSYPADIWSLGLAL-------LECGTGEFPYNAS------------------
STE7-p1-2_Smoe_STE7-plant1         -----NECYSYPADIWSLGLAL-------LECGTGEFPYNAS------------------
STE7-p2-2_Smoe_STE7-plant2         -----GGAYGFESDIWSLGLTL-------LECATGRFPYLPPGQENG-------------
STE7-p2-1_Smoe_STE7-plant2         -----GGAYGFESDIWSLGLTL-------LECATGRFPYLPPGQENG-------------
GK083_Glam_MEK1                    -----NQPYSYVSDVWSMGLTY-------VELLTGSYPYDNV------------------
                                           *    ::*. *

MAP2K7_Hsap_MEK7                   ------------------------------------------------------------
MAP2K6_Hsap_MEK3                   ------------------------------------------------------------
MAP2K5_Hsap_MEK5                   ------------------------------------------------------------
MAP2K4_Hsap_MEK4                   ------------------------------------------------------------
MAP2K3_Hsap_MEK3                   ------------------------------------------------------------
MAP2K2_Hsap_MEK1                   GEPHSISPR------PR---------PP------------------GR------------
MAP2K1_Hsap_MEK1                   GDAAETPPR------PR---------TP------------------GR------------
MAP2K7_Mmus_MEK7                   ------------------------------------------------------------
MAP2K6_Mmus_MEK3                   ------------------------------------------------------------
MAP2K5_Mmus_MEK5                   ------------------------------------------------------------
MAP2K4_Mmus_MEK4                   ------------------------------------------------------------
MAP2K3_Mmus_MEK3                   ------------------------------------------------------------
MAP2K2_Mmus_MEK1                   GEPHSVSPR------PR---------PP------------------GR------------
MAP2K1_Mmus_MEK1                   GDAAETPPR------PR---------TP------------------GR------------
mkk-4_Cele_MEK4                    ------------------------------------------------------------
mek-2_Cele_MEK1                    iela--dsl------e-------------------------------e------------
mek-1_Cele_MEK7                    ------------------------------------------------------------
jkk-1_Cele_MEK7                    ------------------------------------------------------------
F35C8.2_Cele_STE7-Unclassified     ------------------------------------------------------------
F35C8.1_Cele_STE7-Unclassified     ------------------------------------------------------------
E02D9.1_Cele_STE7-Unclassified     ------------------------------------------------------------
STE7_Scer_STE7-Unclassified        ------------------------------------------------------------
PBS2_Scer_STE7-Unclassified        ------------------------------------------------------------
MKK2_Scer_STE7-Unclassified        ------------------------------------------------------------
MKK1_Scer_STE7-Unclassified        ------------------------------------------------------------
Dsor1_Dmel_MEK1                    G-----------------------------------------------------------
lic_Dmel_MEK3                      ------------------------------------------------------------
Mkk4_Dmel_MEK4                     ------------------------------------------------------------
hep_Dmel_MEK7                      ------------------------------------------------------------
sek-1_Cele_MEK3                    ------------------------------------------------------------
VZC374L.1_Cele_MEK4                ------------------------------------------------------------
ZC449.6_Cele_MEK4                  ------------------------------------------------------------
Mek1_Ddis_STE7-Unclassified        -Q-QQQQPL------QQQQQQQQQQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNN
12278_Tthe_STE7-Unclassified       ------------------------------------------------------------
1557_Tthe_STE7-Unclassified        ------------------------------------------------------------
1909_Tthe_STE7-Unclassified        ------------------------------------------------------------
26687_Tthe_STE7-Unclassified       ------------------------------------------------------------
MEK_Spur_MEK1                      GETKN-IRK------TR-------------------------------------------
MEK3_Spur_MEK3                     ------------------------------------------------------------
MKK4_Spur_MEK4                     ------------------------------------------------------------
MKK5_Spur_MEK5                     ------------------------------------------------------------
MKK7_Spur_MEK7                     ------------------------------------------------------------
CC1G_02205_Ccin_MEK1               S---SPSPSD--AQHQR---------TPTHRDSFLLSKKTAKRASKRR------------
CC1G_03368_Ccin_MEK1               GTL-SPQPAGSVSLADL---------PPP---------------KPRR------------
CC1G_01983_Ccin_STE7-Unclassified  ------------------------------------------------------------
CC1G_14241_Ccin_STE7-Unclassified  ------------------------------------------------------------
AqueK243_Aque_MEK1                 GSL---PPR------R-------------------------------N------------
AqueK244_Aque_MEK4                 ------------------------------------------------------------
AqueK245_Aque_MEK4                 ------------------------------------------------------------
AqueK246_Aque_MEK4                 ------------------------------------------------------------
AqueK247_Aque_MEK5                 ------------------------------------------------------------
AqueK248_Aque_MEK7                 ------------------------------------------------------------
STE7-p1-1_Smoe_STE7-plant1         ------------------------------------------------------------
STE7-p1-2_Smoe_STE7-plant1         ------------------------------------------------------------
STE7-p2-2_Smoe_STE7-plant2         ------------------------------------------------------------
STE7-p2-1_Smoe_STE7-plant2         ------------------------------------------------------------
GK083_Glam_MEK1                    ------------------------------------------------------------


MAP2K7_Hsap_MEK7                   ----------------------------CKTDFEVLTKVL--QEEPPLLPGH--------
MAP2K6_Hsap_MEK3                   ----------------------------WGTPFQQLKQVV--EEPSPQLPAD--------
MAP2K5_Hsap_MEK5                   --------------------------QGSLMPLQLLQCIV--DEDSPVLPV---------
MAP2K4_Hsap_MEK4                   ----------------------------WNSVFDQLTQVV--KGDPPQLSNS-E------
MAP2K3_Hsap_MEK3                   ----------------------------WGTPFQQLKQVV--EEPSPQLPAD--------
MAP2K2_Hsap_MEK1                   ----------------PVS-GHGMDSRPAMAIFELLDYIV--NEPPPKLPN---------
MAP2K1_Hsap_MEK1                   ----------------PLS-SYGMDSRPPMAIFELLDYIV--NEPPPKLPS---------
MAP2K7_Mmus_MEK7                   ----------------------------CKTDFEVLTKVL--QEEPPLLPGH--------
MAP2K6_Mmus_MEK3                   ----------------------------WGTPFQQLKQVV--EEPSPQLPAD--------
MAP2K5_Mmus_MEK5                   --------------------------QGSLMPLQLLQCIV--DEDSPVLPL---------
MAP2K4_Mmus_MEK4                   ----------------------------WNSVFDQLTQVV--KGDPPQLSNS-E------
MAP2K3_Mmus_MEK3                   ----------------------------WGTPFQQLKQVV--EEPSPQLPAD--------
MAP2K2_Mmus_MEK1                   ----------------PISVGHGMDSRPAMAIFELLDYIV--NEPPPKLPS---------
MAP2K1_Mmus_MEK1                   ----------------PLS-SYGMDSRPPMAIFELLDYIV--NEPPPKLPS---------
mkk-4_Cele_MEK4                    ------------------------------SLFDQIATVV--SGDPPILHPDSD------
mek-2_Cele_MEK1                    ----------------p--nyhppsnpasmaifemldyiv--ngppptlpk---------
mek-1_Cele_MEK7                    ------------------------------TEFDMMSKIL--NDEPPRLDPA--------
jkk-1_Cele_MEK7                    ----------------------------NDMEFTTLTIIANLNLPSPSLREE-T------
F35C8.2_Cele_STE7-Unclassified     ------------------------------------------------------------
F35C8.1_Cele_STE7-Unclassified     ----------------------------GFSEFTLLSAIV--TTPAPYLERV--------
E02D9.1_Cele_STE7-Unclassified     ----------------------------GLSSYEE---IT-------VEPI---------
STE7_Scer_STE7-Unclassified        ----------------------------PDGILDLLQRIV--NEPSPRLPKD--------
PBS2_Scer_STE7-Unclassified        ----------------------------YDNIFSQLSAIV--DGPPPRLPSD--------
MKK2_Scer_STE7-Unclassified        ---------------------------QNVAPIELLTMIL--TFSP-QLKDEPEL-----
MKK1_Scer_STE7-Unclassified        ---------------------------ANIAPFELLMWIL--TFTP-ELKDEPES-----
Dsor1_Dmel_MEK1                    ---------------------QPTDEPRAMAIFELLDYIV--NEPPPKLEH---------
lic_Dmel_MEK3                      ----------------------------WRTPFEQLRQVV--EDSPPRLPEG--------
Mkk4_Dmel_MEK4                     ----------------------------WDSVFEQLCQVV--QGEPPRLLTSYN------
hep_Dmel_MEK7                      ----------------------------CNTDFEVLTKVL--DSEPPCLPYG-E------
sek-1_Cele_MEK3                    ----------------------------WKTPFEQLKQVV--KEPPPKLPME--------
VZC374L.1_Cele_MEK4                ------------------------------NQMEHIEIVV--NGDSPILLQNMH------
ZC449.6_Cele_MEK4                  ----------------------------DAPILDQVRMVV--YGDPPILDSDH-------
Mek1_Ddis_STE7-Unclassified        NNNNNNNNNVLDISNGG-LVDSGSSVPEGMGFWVLLDCIV--KEEVPILPS---------
12278_Tthe_STE7-Unclassified       ----------------------------SNNFFEVLNNII--DFKIPPLK-N--------
1557_Tthe_STE7-Unclassified        -----------------------------KSIVQFVSNIL--QSKEPTLPDN--------
1909_Tthe_STE7-Unclassified        ---------------------------ENLSFWELLEYFN--MKPAPRLPE---------
26687_Tthe_STE7-Unclassified       ----------------------------NASFFEILAKVM--NFSIPELN-S--------
MEK_Spur_MEK1                      -----------------V-GGVFSDSPRPMAIFELLNYIV--EEHPPRLPS---------
MEK3_Spur_MEK3                     ----------------------------WHDMFQQLTQVV--KGTSPALPKE--------
MKK4_Spur_MEK4                     ----------------------------WNSVFEQLSQVV--KGDPPRLKHN-D------
MKK5_Spur_MEK5                     ---------------------------QELSPIALLQCIV--EEHPPRLPS---------
MKK7_Spur_MEK7                     ------------------------------------------------------------
CC1G_02205_Ccin_MEK1               ----------------SKLTYNPDGQLSTMSIFELIHQIV--QEPSPRLP-S--------
CC1G_03368_Ccin_MEK1               ----------------QKNA-NGNGSTTKKDKRKSKGHIV--NEPAPRLTPE--------
CC1G_01983_Ccin_STE7-Unclassified  ------------------------------PPIELMMYIT--NSEPPRLEDEP-------
CC1G_14241_Ccin_STE7-Unclassified  ----------------------------YSNVFAQLTAIV--HGPPPCLPSG--PPPPLS
AqueK243_Aque_MEK1                 ----------------P---YASHANAIRMPVFELLQMIF--TDDPPRLPD---------
AqueK244_Aque_MEK4                 ----------------------------LRSIFGLIEMIV--KGSPPRLTSD--------
AqueK245_Aque_MEK4                 ----------------------------YRNLFEQIKLVV--EGAPPQLPDD--------
AqueK246_Aque_MEK4                 ------------------------------TIFDQLNAVV--SGDPPSLPPE--------
AqueK247_Aque_MEK5                 ------------------------------------------------------------
AqueK248_Aque_MEK7                 ----------------------------FSSEFDLLTHIV--QAPPPLLDED--------
STE7-p1-1_Smoe_STE7-plant1         -----------------------------KGPVNLMLQVM--YDPSPAPPAD--------
STE7-p1-2_Smoe_STE7-plant1         -----------------------------KGPVNLMLQVM--YDPSPAPPAD--------
STE7-p2-2_Smoe_STE7-plant2         ----------------------------YLNFYELLETIV--EQPAPVASPE--------
STE7-p2-1_Smoe_STE7-plant2         ----------------------------YLNFYELLETIV--EQPAPVASPE--------
GK083_Glam_MEK1                    -----------------------------NSFWDAMNVIV--NGAPPLLKED--------


MAP2K7_Hsap_MEK7                   -------------------------------MGFSGDFQSFVKDCLTKDHRKRPKYNKLL
MAP2K6_Hsap_MEK3                   --------------------------------KFSAEFVDFTSQCLKKNSKERPTYPELM
MAP2K5_Hsap_MEK5                   -------------------------------GEFSEPFVHFITQCMRKQPKERPAPEELM
MAP2K4_Hsap_MEK4                   ------------------------------EREFSPSFINFVNLCLTKDESKRPKYKELL
MAP2K3_Hsap_MEK3                   --------------------------------RFSPEFVDFTAQCLRKNPAERMSYLELM
MAP2K2_Hsap_MEK1                   -------------------------------GVFTPDFQEFVNKCLIKNPAERADLKMLT
MAP2K1_Hsap_MEK1                   -------------------------------GVFSLEFQDFVNKCLIKNPAERADLKQLM
MAP2K7_Mmus_MEK7                   -------------------------------MGFSGDFQSFVKDCLTKDHRKRPKYNKLL
MAP2K6_Mmus_MEK3                   --------------------------------KFSADFVDFTSQCLKKNSKERPTYPELM
MAP2K5_Mmus_MEK5                   -------------------------------GEFSEPFVHFITQCMRKQPKERPAPEELM
MAP2K4_Mmus_MEK4                   ------------------------------EREFSPSFINFVNLCLTKDESKRPKYKELL
MAP2K3_Mmus_MEK3                   --------------------------------QFSPEFVDFTSQCLRKNPAERMSYLELM
MAP2K2_Mmus_MEK1                   -------------------------------GVFSSDFQEFVNKCLIKNPAERADLKLLM
MAP2K1_Mmus_MEK1                   -------------------------------GVFSLEFQDFVNKCLIKNPAERADLKQLM
mkk-4_Cele_MEK4                    ------------------------------DFHYSLPLVKFINTCLTKDRRHRPKYDTLK
mek-2_Cele_MEK1                    -------------------------------rfftdevigfvskclrklpseratlkslt
mek-1_Cele_MEK7                    --------------------------------KFSPDFCQLVESCLQRDPTMRPNYDMLL
jkk-1_Cele_MEK7                    ------------------------------KRSFSPLFIEFLDLCLRKDVRERPEYRQLM
F35C8.2_Cele_STE7-Unclassified     ------------------------------------------------------------
F35C8.1_Cele_STE7-Unclassified     --------------------------------TFSNN-----------------------
E02D9.1_Cele_STE7-Unclassified     -------------------------------DGFPESLAVLISNCLYSH-------TNFV
STE7_Scer_STE7-Unclassified        -------------------------------RIYSKEMTDFVNRCCIKNERERSSIHELL
PBS2_Scer_STE7-Unclassified        --------------------------------KFSSDAQDFVSLCLQKIPERRPTYAALT
MKK2_Scer_STE7-Unclassified        ------------------------------DISWSKTFRSFIDYCLKKDARERPSPRQML
MKK1_Scer_STE7-Unclassified        ------------------------------NIIWSPSFKSFIDYCLKKDSRERPSPRQMI
Dsor1_Dmel_MEK1                    -------------------------------KIFSTEFKDFVDICLKKQPDERADLKTLL
lic_Dmel_MEK3                      --------------------------------TFSPEFEDFIAVCLQKEYMARPNYEQLL
Mkk4_Dmel_MEK4                     ------------------------------GMEFSKEFVDFVNTCLIKKESDRPKYSRLL
hep_Dmel_MEK7                      ------------------------------GYNFSQQFRDFVIKCLTKNHQDRPKYPELL
sek-1_Cele_MEK3                    -------------------------------SGFSVDCQYFVKRCLEKDYNERPKYPELL
VZC374L.1_Cele_MEK4                ------------------------------NLHYTDPLCRFINTCLRKNKDDRPKYVNLK
ZC449.6_Cele_MEK4                  --------------------------------EVSMSMKRFIALCTIKDRNLRASFDDLK
Mek1_Ddis_STE7-Unclassified        --------------------------------TFSKEFRSFISECLQKEPTERPTASNLL
12278_Tthe_STE7-Unclassified       --------------------------------INSPEFTNFIEICLKSDQNERADITQLL
1557_Tthe_STE7-Unclassified        -------------------------------GKYSAALMDFVKKCVAKEQKDRLDISDLL
1909_Tthe_STE7-Unclassified        --------------------------------NYSEEMKDFVAKCFKKSPLDRPHSHDLL
26687_Tthe_STE7-Unclassified       --------------------------------IKSKEFIQFVEQCTKINPKERADVVQLL
MEK_Spur_MEK1                      -------------------------------RAFSEEFVDFVDVCLIKNPNERADLKKLK
MEK3_Spur_MEK3                     --------------------------------KFSEDIQDFINKCLKKNCTERPSYTRLL
MKK4_Spur_MEK4                     ------------------------------FYSYSEDFISFVNKCLTKDEKYRPKYKNLL
MKK5_Spur_MEK5                     -------------------------------DKFSAPFVDFVNRCLQKRPGDRPKPQDLM
MKK7_Spur_MEK7                     ------------------------------------------------------------
CC1G_02205_Ccin_MEK1               -------------------------------DKFPADAVDLVDICLLKNPEERQTPKALL
CC1G_03368_Ccin_MEK1               -------------------------------GRYPKAAESFIDACLLKDPDARQTPKDLL
CC1G_01983_Ccin_STE7-Unclassified  ------------------------------GVNWSEEMKDFIKQALTVDPVDRPTPKDML
CC1G_14241_Ccin_STE7-Unclassified  PDDDSSFEEPVLPPTLDDQDPLISPTTGRQRPGYSPFARDWVNKCMRKDAKERATYKELL
AqueK243_Aque_MEK1                 -------------------------------EYFDDKFKSFVALCLQKDVKKRGTLSALL
AqueK244_Aque_MEK4                 --------------------------------RFSGEHKDFVAQCLTKSRDSRPRYKDLN
AqueK245_Aque_MEK4                 -------------------------------GTFSEDFRDFVSKCLTKERDERPRYEVLN
AqueK246_Aque_MEK4                 --------------------------------NFTRELREFTAACLVKDSDQRPNYVQLQ
AqueK247_Aque_MEK5                 ------------------------------------------------------------
AqueK248_Aque_MEK7                 --------------------------------KFSPNFYDFVAQCLCKDVDERPQYDKLL
STE7-p1-1_Smoe_STE7-plant1         --------------------------------RFSCEFRSFVEACLRKDADTRPTAEQLL
STE7-p1-2_Smoe_STE7-plant1         --------------------------------RFSCEFRSFVEACLRKDADTRPTAEQLL
STE7-p2-2_Smoe_STE7-plant2         --------------------------------MFSAEFCSLISACIQKEPKDRMTAAELL
STE7-p2-1_Smoe_STE7-plant2         --------------------------------MFSAEFCSLISACIQKEPKDRMTAAELL
GK083_Glam_MEK1                    -------------------------------AGYSPGLCDLVNAMLEKDPSKRMTAAQLL


MAP2K7_Hsap_MEK7                   ----------EHSFI
MAP2K6_Hsap_MEK3                   ----------QHPFF
MAP2K5_Hsap_MEK5                   ----------GHPFI
MAP2K4_Hsap_MEK4                   ----------KHPFI
MAP2K3_Hsap_MEK3                   ----------EHPFF
MAP2K2_Hsap_MEK1                   ----------NHTFI
MAP2K1_Hsap_MEK1                   ----------VHAFI
MAP2K7_Mmus_MEK7                   ----------EHSFI
MAP2K6_Mmus_MEK3                   ----------QHPFF
MAP2K5_Mmus_MEK5                   ----------GHPFI
MAP2K4_Mmus_MEK4                   ----------KHPFI
MAP2K3_Mmus_MEK3                   ----------EHPFF
MAP2K2_Mmus_MEK1                   ----------NHAFI
MAP2K1_Mmus_MEK1                   ----------VHAFI
mkk-4_Cele_MEK4                    ----------SFDFY
mek-2_Cele_MEK1                    ----------advff
mek-1_Cele_MEK7                    ----------QHPFV
jkk-1_Cele_MEK7                    ----------KHDFY
F35C8.2_Cele_STE7-Unclassified     --------------T
F35C8.1_Cele_STE7-Unclassified     --------------Y
E02D9.1_Cele_STE7-Unclassified     ----------KMFFL
STE7_Scer_STE7-Unclassified        ----------HHDLI
PBS2_Scer_STE7-Unclassified        ----------EHPWL
MKK2_Scer_STE7-Unclassified        ----------KHPWI
MKK1_Scer_STE7-Unclassified        ----------NHPWI
Dsor1_Dmel_MEK1                    ----------SHPWI
lic_Dmel_MEK3                      ----------KHSFI
Mkk4_Dmel_MEK4                     ----------EMPFI
hep_Dmel_MEK7                      ----------AQPFI
sek-1_Cele_MEK3                    ----------AMPFM
VZC374L.1_Cele_MEK4                ----------TFSFY
ZC449.6_Cele_MEK4                  ----------K---T
Mek1_Ddis_STE7-Unclassified        ----------NHEFV
12278_Tthe_STE7-Unclassified       VNTTSFSSFNEHPFL
1557_Tthe_STE7-Unclassified        ----------KHEWI
1909_Tthe_STE7-Unclassified        ----------NHEMV
26687_Tthe_STE7-Unclassified       ----------ELPFV
MEK_Spur_MEK1                      ----------VHTFA
MEK3_Spur_MEK3                     ----------EHEFI
MKK4_Spur_MEK4                     ----------EYKFI
MKK5_Spur_MEK5                     ----------QHPFI
MKK7_Spur_MEK7                     --------------I
CC1G_02205_Ccin_MEK1               --------VRNHPWI
CC1G_03368_Ccin_MEK1               ----------KHEWI
CC1G_01983_Ccin_STE7-Unclassified  ----------EHPWI
CC1G_14241_Ccin_STE7-Unclassified  ----------EHPWL
AqueK243_Aque_MEK1                 ----------EHKFV
AqueK244_Aque_MEK4                 ----------AHSFI
AqueK245_Aque_MEK4                 ----------GHKFI
AqueK246_Aque_MEK4                 ----------EKEFF
AqueK247_Aque_MEK5                 --------------Y
AqueK248_Aque_MEK7                 ----------LHPLI
STE7-p1-1_Smoe_STE7-plant1         ----------QHPFI
STE7-p1-2_Smoe_STE7-plant1         ----------QHPFI
STE7-p2-2_Smoe_STE7-plant2         ----------KHPFI
STE7-p2-1_Smoe_STE7-plant2         ----------KHPFI
GK083_Glam_MEK1                    ----------KLPFC