Protein (view, download) , Domain (view, download)
ROS_Hsap        MKNIYCLIPK--------------------------------------------------
sev_Dmel        MTTTHINQQAPGTSSSSSNSQNASPSKIVVRQQSSSFDLRQQLARLGRQLASGQDGHGGI
ROS_Mmus        MKNICWLTLK--------------------------------------------------
ROS_Spur        MASIISDT----------------------------------------------------
rol-3_Cele      MLSLHLRSLA--------------------------------------------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        -------LVNFATLGC-LWISVVQCTVLNS----CLKSCV-TNLGQQLDLGTP-------
sev_Dmel        STILIINLLLLILLSI-CCDVCRSHNYTVHQSPEPVSKDQMRLLRPKLDSDVVEKVAIWH
ROS_Mmus        -------LVKFVVLGCIIWISVAQSTVLSS----CLTSCV-TNLGRQLDSGTR-------
ROS_Spur        ----------------------------GQ----CDAPC-------------R-------
rol-3_Cele      -----ILFLLFFLL----HDVVKSATVFSSSLKTCQSQCEERNLAYPLDSGEVHWTGLAE
AqueK407_Aque   ----------------------------------CCCCCF-V--G---------------


ROS_Hsap        HN--------------------------------------------------LSEPCIQG
sev_Dmel        KHAAAAPPSIVEGIAISSRPQSTMAHHPDDRDRDRDPSEEQHGVDERMVLERVTRDCVQR
ROS_Mmus        YN--------------------------------------------------LSEACIHG
ROS_Spur        -----------------------------------------------------NSSCSTG
rol-3_Cele      YNY-------------S----------------------------------SRISSCRHG
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        CHF---W--N----------S---VDQKNCALKCNDTYATVC-ERESCEVGCSSAEGAY-
sev_Dmel        CIVEEDLFLDEFGIQCEKADNGEKCYKTRCTKGCAQWYRALK-ELESCQEACLSLQF---
ROS_Mmus        CQF---W--N----------S---VDQETCALKCNDTYATIC-ERESCEVGCSNAEGSY-
ROS_Spur        CSS---W--D----------N---STLSQCHAVCNETYTSEPFRVQYCQSGCLFAENEY-
rol-3_Cele      CED---V--D----------E----RESKCDVKCSEEGI----VSNACKQGCRAVLVSFL
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ------------EEEVLENA------------------------DLPTAPFASSIGSHNM
sev_Dmel        ---------YPYDMPCIGACEMAQRDYWHLQRLAISHLVERTQPQLERAPRADG-QSTPL
ROS_Mmus        ------------EEEVLEST------------------------ELPTAPFASSIGSHGV
ROS_Spur        ------------AKAVIDEI------------------------GQPSSPQPSNMGTTSL
rol-3_Cele      AQAQALLIQVHVNMEVLETSMK---LKWEFPETLAEELKEIANADI--------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        TLRWKS---A-NFSGVKYIIQWKYAQLLG-SWTYT-----------------------KT
sev_Dmel        TIRWAMHFPEHYLASRPFNIQYQFVDHHGE-ELDLEQEDQDASGETGSSAWFNLADYDCD
ROS_Mmus        TLRWNP---A-NISGVKYIIQWKYAQLPG-SWTFT-----------------------ET
ROS_Spur        TLSWTA---A-SHQDVRYLVQWRYVEGGGEAWNYYGS--------------------GEP
rol-3_Cele      --FWF----SQ-TKPLNGILGWRWTSLPQN-SFR-------------------------N
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        VSRPSYVVKPLHPFT---EYIFRVVWIFTAQ--LQLYSPPSPSYRTHPHGVPETAPLIRN
sev_Dmel        EYYVCEILEALIPYT---QYRFRFELPFGENRDEVLYSPATPAYQTPPEGAPISAPVIEH
ROS_Mmus        VSKLSYTVEPLHPFT---EYIFRVVWIFTAQ--LHLYSPPSPSYRTHPYGVPETAPLILN
ROS_Spur        ISETTLDITDLIPYA---LYQFRVVWVITPR--HTLTSPATSNVQTQPSGVPSTAPIITS
rol-3_Cele      SSLSS---EVHVPFEHGEHVEVRLAL--SYRN-QVLVS-RTTTYHLPLSKSGTTLEVIGQ
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        IESSSPDTVEVSWDPPQFPGGPILGYNLRLISKN------QK-LDAGTQ----RTSFQFY
sev_Dmel        LMGLDDSHLAVHWHPGRFTNGPIEGYRLRLSSSE------GNA-TSEQLVPAGRGSYIFS
ROS_Mmus        MESWSPDTVEVSWAPPHFPGGPILGYNLRLISKN------QK-LDSGTQ----RTSFQFY
ROS_Spur        IVSSSPTTISLTWDPPPFPNGPIIGYTIAVQNFFNETGIVLD-VDGSTT----EATVVDS
rol-3_Cele      L-QLSDDRVAVCYR----TNQPTPKFKLTIMTLN------DNTINTEES----IARCHLF
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        STLP-NTIYRFSIAAVNEVGEGPEAESSITTSS----SAVQQ-----EEQWLFLSRKTS-
sev_Dmel        QLQ-AGTNYTLALSMINKQGEGPVAKGFVQTHS-A---RNEKPAKDLTESVLLVGRRAVM
ROS_Mmus        STLP-NTTYRFSIAAVNEVGEGPEAESTVTTPS----PSVQE-----EEQWLFLSRKTS-
ROS_Spur        SLRA-LTLYAVSVRARNMEGGGISDMVNVTTGAEPENVAVDY-----WENFIFISDSDG-
rol-3_Cele      SNLPRDNCCKASISAIDEHGATTA-FVEIKLDF-Y-VNQVEIELVSVASSRLIFSNGTH-
AqueK407_Aque   -------------------------------------------------------RK---


ROS_Hsap        -----------LRKRSLK--HLVDEAHCLRLD-AIYHNITGISVDVHQQI-VYFSEGTLI
sev_Dmel        WQSLEPAGENSMIYQSQE--ELADIAWS----KREQ-QLWLLNVHGELRS-LKFESGQMV
ROS_Mmus        -----------LRKRSLK--YLVDEAHCLWSD-AIHHNITGISVYAQQQV-VYFSEGTVI
ROS_Spur        ----------RIHRRTID------------------------------------------
rol-3_Cele      -----------LLESEIDQYALGDSATVIPFPLPTDDTITAIAGISDTTIAIGSSKGSLW
AqueK407_Aque   ------------------------ETHAFRPD----------------------------


ROS_Hsap        WAKKAANMSD------VSDLRIFYRGSGLISSISIDWLYQRMYFIM-DELVCVCDLENC-
sev_Dmel        SPA----------QQLKLDLGNISSGRWVPRRLSFDWLHHRLYFAM-ESP-----ERN--
ROS_Mmus        WMKGAANMSD------VSDLRIFYQGSGLVSSISIDWLYQRMYFIM-DKLVYVCELKNC-
ROS_Spur        ----PANLTL------ATSEVLYTNQSTAPTKLDVDWLNEQLYFVQ-GTEILRCDLNVS-
rol-3_Cele      TYQMSANQTDEDQPSSVIQLKTVGEMDTKINQIEIDHIQRTLYAVQHDKGIIRCKLRTME
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        -----SNIEEITPPSI-----------SAP-QKIVADSYNGYVFYLLRD-GIYRADLPVP
sev_Dmel        ----QSSFQIISTDLLGESTQKVGESFDLPVEQLEVDALNGWIFWRNEE-SLWRQDLHGR
ROS_Mmus        -----SNLEEITPFSL-----------IAP-QKVVVDSYNGYLFYLLRD-GIYRVNLPLP
ROS_Spur        ------GCSVAVANLG-----------SVP-VEMKVDPFSGYLFWSERDVGIRRTSLTSS
rol-3_Cele      AEESPNCVLIVNNDAL-----------NAP-KEITLDSVNGHVYTLNADNKVYRTEMVAF
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        SGRCAEAVRIVESC----------------------------------------------
sev_Dmel        MIHRL--LRIRQ------------------------------------------------
ROS_Mmus        SGRDTKAVRIVESG----------------------------------------------
ROS_Spur        TVEASSADIIINLLGQSSFTVLSETFQILYSNSTGNSMYSASLDGGNQKAMHVAEDTSNH
rol-3_Cele      NATGI--ETVAS------------------------------------------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ------------------------------------------------------------
sev_Dmel        ------------------------------------------------------------
ROS_Mmus        ------------------------------------------------------------
ROS_Spur        QFINVTSIVYFNSSLTWTFARETGGVVACAFDPSYNHRDNEQIFFEGNPGQFSQGDLFLC
rol-3_Cele      ------------------------------------------------------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ------------------------------------------------------------
sev_Dmel        ------------------------------------------------------------
ROS_Mmus        ------------------------------------------------------------
ROS_Spur        VDGYHGLDVFYPTYQPIPIPAFPPTDLQVLFTEDEIGQPSSPQPSNIGTTSLTLSWTAAS
rol-3_Cele      ------------------------------------------------------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ------------------------------------------------------------
sev_Dmel        ------------------------------------------------------------
ROS_Mmus        ------------------------------------------------------------
ROS_Spur        HQDVRYLVQWRYVEGGGEAWNYFGSGEPISETTLDITDLIPYTLYQFRVVWVITPRHTLT
rol-3_Cele      ------------------------------------------------------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ------------------------------------------------------------
sev_Dmel        ------------------------------------------------------------
ROS_Mmus        ------------------------------------------------------------
ROS_Spur        SQATSSVQTLPFGVPSTAPTITSIVSSSPTTISLTWDPPPFPNGPIIGYTIAVQNFFNEA
rol-3_Cele      ------------------------------------------------------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ------------------------------------------------------------
sev_Dmel        ------------------------------------------------------------
ROS_Mmus        ------------------------------------------------------------
ROS_Spur        RIVLGVGGSTTEATVVDSSLRASTLYAVSVRARNMEGEGISDTVNITTGAEPQNLGVVPY
rol-3_Cele      ------------------------------------------------------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ------------------------------------------------------------
sev_Dmel        ------------------------------------------------------------
ROS_Mmus        ------------------------------------------------------------
ROS_Spur        LVIGVTSLSFTNLSEMSSVSLVEYGKRIIDSDPLLNDIHTVDNENSTISDVAVDYWENFI
rol-3_Cele      ------------------------------------------------------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ------------------------------------------------------------
sev_Dmel        ------------------------------------------------------------
ROS_Mmus        ------------------------------------------------------------
ROS_Spur        FISDSDGRIHRRTIDPANLTLAPSEVLYTDQSTAPTKLDVDWLNEQLYFVQGTEKLSPQL
rol-3_Cele      ------------------------------------------------------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ------------------------------------------------------------
sev_Dmel        ------------------------------------------------------------
ROS_Mmus        ------------------------------------------------------------
ROS_Spur        ALAAVCGTFSMKNEESIHYSGEILRCDLNVSGCSVAVANLGSVPVEMKVDPFSGYLFWSE
rol-3_Cele      ------------------------------------------------------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ---------------------------TLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSA
sev_Dmel        ----------------------------PGWFLVQPQHFIIHLMLPQEGKFLEISYDGGF
ROS_Mmus        ---------------------------TLKDFAVKPQSKRIIYFNDTMQLFMSTFLDGSA
ROS_Spur        QDVGIRRTSLTSSTVEASSVDIIINLSGQSSFTVLSETFQILYSNSTGNSMHSASLDGSN
rol-3_Cele      ----------------------------LQYLQ-DMSPSNGIFFDVSKFLLYSALQNGSM
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        SHL--------ILPRIPFA----------DVKSFACENNDFLVTDG-KVIFQQDALSFNE
sev_Dmel        KHP---------LPLPPPSNGAGNGPASSHWQSFALLGRSLLLPDSGQLILVEQQGQAAS
ROS_Mmus        FHR--------VLPWVPLV----------TVKSFACENNDFLITDG-KAIFQQDSLSFNE
ROS_Spur        QKA--------M-HVAEDT----------SNHQFINVTSIVYFNSSLTWTFARETGSVAS
rol-3_Cele      MTLNPVTDHVHIFKDVGYA----------DIQHFRIKN-DLIYWMK-KKCGETDADE--N
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        FIVGCDLSHIEE----------------------FGFGNLVIFGSSSQ---------LHP
sev_Dmel        PSASWPLKNLPD-----------------------CWAVILLVPESQP---------LTS
ROS_Mmus        FIVGCDLSHIEE----------------------FGFGNLVIFGSSVQ---------SYP
ROS_Spur        CFLGDPNYNYRDTERIFFEGNPGQFTQGDLFLCVDGYHGLDVFYPTYQ---------PIP
rol-3_Cele      CIFAENLQRSEE-----------------------DIPNKFTYSSSLMSFGVLEEILLKP
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        LPG-RPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVS
sev_Dmel        AGG-KPHSLKALLGAQAAKISWKEPERNP--------------YQSADAARSWSYELEVL
ROS_Mmus        LPG-HPQEVSVLFGSREALIQWTPPALAIG--------------ASPSAWQNWTYEVKVY
ROS_Spur        IPAFPPTDLQVLFTE------------------------------GEEAWEEWLYEILLT
rol-3_Cele      RIT-AVSTIAMLTSDKTARVSWDESNTLP-------------FQAQGSSWRNFTYFLKVT
AqueK407_Aque   ------------------------------------------------------YE----
                                                                      *

ROS_Hsap        TQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKR-PGPWSEPSVGTTLVPA-S
sev_Dmel        DVASQS-AFSIRNIRGPIFGLQRLQPDNLYQLRVRAINVDGEPGEWTEPLAARTWP-L-G
ROS_Mmus        SQDILEITQVFSNISGTMLNVPELQSSTKYTVSVRASSPKG-PGPWSAPSVGTTLVPA-T
ROS_Spur        NLQIGN-TVTLTGLQEDSALVDNLNGSTEYSVQVRAYSIGG-LGPLSETFSGSTLIEV-D
rol-3_Cele      APDITDFSPIEIYTSNTEMKI-DVTPGNIYNAQVQVCSDDFCSIPTS--TSNTALPDLGD
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        EPPFIMAVKE-DGLWSKPLNSFGPG-EFLSSDIGNV-SDMDWYNNSLYYSDTKGDVFV--
sev_Dmel        PHRLRWASRQ-GSVIHT--NELGEGLEVQQEQLERLPGPMTMVNESVGYYV-TGDGLLHC
ROS_Mmus        EPPFIMAVKE-DGLWSKPLCSFGPG-EFLSSDVGNV-SDMDWYNNSLYYSDTKGNVYV--
ROS_Spur        VEPYLILANA-TDVWRSQLDGNAES-RLLSP-QATI-KDIEWYQGYYIWSSTMGDLY---
rol-3_Cele      VVPFVFTKRQADDIISV--DILGNIIPAD-------------------------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ----WLLNGTDISENYH-L-PSI-AGAGALAFEWLGHFLYWAGKTY-VIQRQ------SV
sev_Dmel        INLVHSQWGCPISEPLQ--------HVGSVTYDWRGGRVYWTDLARNCVVRM------DP
ROS_Mmus        ----RPLNGMDISENYH-I-PSI-VGAGALAFEWLGHFLYWAGKTY-VIQRQ------SV
ROS_Spur        ----RSAEGDVIEEQLTFVPPGVRSSVDAIAVDWLSEFIYWADRDQNQIIRGRLSNQSSV
rol-3_Cele      -------DSVKIVEKLQ---------YPHV-LDNTTKTVYLAG--DHSVSRS------I-
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        LTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESS--LVLQTQPWFSGKK
sev_Dmel        WSGSRELLPV--FEANFLALDPRQGHLYYATSSQLSRHGSTPDEA--VTYYRVNGLEG-S
ROS_Mmus        LTGHTDIVTHVKLLVNDMAVDSVGGYLYWTTLYSVESTRLNGESS--LVLQAQPWLSGKK
ROS_Spur        VTSPTSINA-FANDVQDIAIDSVQAYIYWTSSSSVEGSRLNGESP--LVFYEIGDLSLDV
rol-3_Cele      --------------------------ILIASSYKITSYRLPTTFDFEYFSCEEPLEACSE
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        VIALTLDLSDGLLYWLVQDSQ-C----IHLYTAVLRGQSTGDTTITEFAAWSTSEISQNA
sev_Dmel        IASFVLDTQQDQLFWLVKGSG-A----LRLYRAPLTAGGDSLQMIQQIKGVFQAVPDSLQ
ROS_Mmus        VIALTLDLSDGLLYWLVQDNQ-C----IHLYTAVLRGWSGGDATITEFAAWSTSEISQNA
ROS_Spur        VAGLTLDLGGGYVYWFVVSRQ-GVTEELKLFRARLAGISPDPMSTTEEIGEVLSETTSLA
rol-3_Cele      VMGISSDDTTGMVHFLTQARNGT----ITLWESDPENR-----TPRDIASVPSIVPFRRF
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        LMYYSGRLFWING--FRIITTQEIGQKTSVSVLEPARFNQFTIIQT-SLKPLPGNFSFTP
sev_Dmel        LLRPLGALLWLERSGRRARLVRLAAPLDVMELPTPDQASPASALQLLDPQPLPPRD---E
ROS_Mmus        LMYYSGRLFWING--FRIITAQEIGQRTSVSVSEPAKFNQFTIIQT-SLKPLPGNFSSTP
ROS_Spur        LHFYSSKLFWINSQ-SRVEVSDDRGQRQALL--PATDVQALTIVQE-TLKPLPEGYSERP
rol-3_Cele      LILHDKMILVT-KNN------HIVQTDKKLK-----VVNVATELERV-DHILPLRY---A
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        KVIPDSV-QESSFRI-EGNASSFQILWNGPPAVDWGVVFYSVEFSAHS------KFLASE
sev_Dmel        GVIPMTV-LPDSVRLDDGHWDDFHVRWQPSTSGGNHSVSYRLLLEFGQ------RLQT-L
ROS_Mmus        KVIPDPV-QESSFRI-EGHTSSFQILWNEPPAVDWGIVFYSVEFSTHS------KFLIIE
ROS_Spur        TVVAEEI-SPSSIQV-TGTWDDFNITWQASTEVNYGIVFYTIAVTAPE------QTYT-E
rol-3_Cele      T-ISHKIEFSDEIKFIDGSKTNLQ--WTLSPPLEAGTVLFKVSIFREKMGGQDPPIIT-I
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        QH----SLPVFTVEGLEPYA-LFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFI
sev_Dmel        DL----STPFARLTQLPQAQLQLKISITPRTAWRSGDTTRVQLTTPPVAPSQPRRLRVFV
ROS_Mmus        QQ----SLPIFTVEGLEPYT-LFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFI
ROS_Spur        TV----QSASYNIKNLTPFQ-SLDITISPYTYWATTPETAAQMMSPMSVPSVPLNPRAFA
rol-3_Cele      QSETNFTIPSEVLEAWSSAQ-RFDVSVQAMTPWATAVLNRTGLTAPVKPPTSPTQLRIFA
AqueK407_Aque   ------------LRGLRALN-SRT------------------------------------
                            :

ROS_Hsap        LPSGKC-CNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSV
sev_Dmel        ERLATA-LQEANVSAVLRWDAPEQGQEAPMQA-LEYHISCWVGSELHEE----LRLNQSA
ROS_Mmus        LSSGRY-TKKNEVVVEFRWNKPKHENGVLTKFEIFYHISKQSGTNRSTEDWMSASVIPPV
ROS_Spur        IDSTDIMTGTTMYSAEFRWSEPAEINGVFEGYNVSW------GTDV--EQLTVFNVSVDV
rol-3_Cele      TQQ-KT-VDGPRALISFFWGPPSEWNGTPYQ--YIVNCTKDDGKL--------ITIDSSE
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        MSFQL-----EG------------MSPR-----------------CFIAFQVRAFTS---
sev_Dmel        LEARV-----EH------------LQPD-----------------QTYHFQVEARVAATG
ROS_Mmus        MSFQL-----EA------------VSPE-----------------YTVAFQVRVFTS---
ROS_Spur        DVFSF-----AN------------LTAN-----------------TTYFFQVEGFTS---
rol-3_Cele      LKPLVKLFAIDSTNSLISINDLAHEEPRRETRQVAQPVKLEYQAMAFIGEDLYAVR---K
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        KGPGPYADVVKSTTSEINPFPHLITLLGNKIV-FLDMDQNQVVWTF-S--AERVISAVCY
sev_Dmel        AAAGAASHAL-HVAPEVQAVPRVLYANAEFIG-ELDLDTRNRRRLVHT--ASPVEHLVGI
ROS_Mmus        KGPGPFSDIVMSKTSEIKPCPYLISLLGNKIV-FLDMDQNQVLWTF-S--LEGDVSTVGY
ROS_Spur        VGSGPATDPVSITTGVSPPPPTIVVSKGNAGVTLTDPDTKEEIPLL-G---GIAISVVAF
rol-3_Cele      EGESAQPVLV-------------------------QIDTNHIDNTVHKVSIGGDVTRIDA
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        TADNEMG---YYAEGDSLFLLHLHNRSSS------ELFQDSLVFDITVITIDWISRHLYF
sev_Dmel        EGEQRLL---WVNEH-VELLTHVPGSAPA------KLAR--MRAEVLALAVDWIQRIVYW
ROS_Mmus        TTDDEMG---YFAQGDTLFLLNLRNHSSS------KLFQDALVSDIRVIAVDWIARHLYF
ROS_Spur        VASEDKV---FFVE----------------------------------------------
rol-3_Cele      MTSDWVGNRLIFVAGTNVYQLSLEPFLSTSLLNPHKLIQLTSATDAKQLAYDPFMNTAYL
AqueK407_Aque   ----------------------------Q------SLTNPH-------------------


ROS_Hsap        ALKESQ--NGMQVFDVDL---EHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNF
sev_Dmel        AELDATAPQAAIIYRLDLCNFEGKILQGERVWSTPRGRLLKDLVALPQAQSLIWLEYEQG
ROS_Mmus        ALKASQ--NGTQIFNVDL---EHKVKSPREVKTCKAHTTIISFSIYPLLSRLYWTEVSDL
ROS_Spur        ------------------------------------------------------------
rol-3_Cele      L---TK--NGS-LFALDM---NKNTEANLAL----TVSCLASQTVTWMMTEFAWNRASS-
AqueK407_Aque   ----------------------------------------------------YWS-----


ROS_Hsap        GYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLE----KPL
sev_Dmel        S------------------PRN----------------GSLRGRNLTDGSELEWATVQPL
ROS_Mmus        GHQMFYCNISNHTSQHVLQPKASNQ-HGRSQCSCNVTESELSGAMTVDTSDPD----RPW
ROS_Spur        ------------------------------------------------------------
rol-3_Cele      ----------------------------------------------------------PK
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        IYFA------KAQEIWAMDL-EGCQCWRVITVPAMLAG---KTLVSLTVDGDLIYWIITA
sev_Dmel        IRLHAGSLEPGSETLNLVDN-QGKLCVYDVARQLCTAS---ALRAQLNLLGEDSIAGQLA
ROS_Mmus        IYFT------KRQEIWAMDL-EGCQCWKVIMVPT-IPG---KRIISLTVDGEFIYWIMKT
ROS_Spur        -----------------------------------------------------------T
rol-3_Cele      IYAL------TWNGLIYVDLTEDSQCNEVRIDWTKFGDKGLKDISSFAIADKLFAFV-T-
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        KDSTQIYQAKKGN--------GAIVSQVKALRSRHILAYSSV-MQPFPDKAFLSLASDT-
sev_Dmel        QDSGYLYAVKNWSIRAYGRRRQQLEYTVELEPEEVRLLQAHN-YQAYPPKNCLLLPSSGG
ROS_Mmus        KDDAQIYQAKKGS--------GAILSQVKASRSKHILAYSSA-LQPFPDKAYLSLASDM-
ROS_Spur        SGDLEIYRSKL-D--------GSDREEVE--------GFTSVGSGPATDPVSITTGVSP-
rol-3_Cele      SSEMLIY----------GKDTV-TPITIANPPLKQILAVSQS-SQPYPERSCFELPSSKG
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        VEPTILN-ATNTSLTIRLPLAKTNLTWY-GITSPTPTYLVYYAEVNDRKNSSDLKYR---
sev_Dmel        SLLKATD-CEEQRCLLHLPMITASEDC--PLPIPGVRYQLNLTLAK-EPGSEEHDHGMEP
ROS_Mmus        VEATILY-ATNTSLTLKLPPVKTNLTWH-GITHPTSTYLIYYMEAN-RANSSDRRHK---
ROS_Spur        PPPTIVVSKGNAGVTLTDPDTKEETPLLGGIAISVVAFVA--------------------
rol-3_Cele      IVFSIVN-EGKTGSFLEVTKSSSSSSCQ-EVSMPQTQYEIYFTRK----NTDKVKH----
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ----ILEFQDSIALIED-LQPFSTYMIQIAVKNYYSDPLE---HLPPGKEIWGKTKNGVP
sev_Dmel        LGQWLLGAGESLNLT-D-LLPFTRYRVSGILSSFYQKKLALPTLVLAPLE--LLTASATP
ROS_Mmus        ----MLESQENVARIEG-LQPFSMYMIQIAVKNYYSEPLE---HLPLGKEIQGQTKSGVP
ROS_Spur        ------------------------------------------------------------
rol-3_Cele      ----VRSFSDRIHVENGILDKETDYDVTVTWLNRYS-PAS---GVSASKS--FRTGFGYP
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        EAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLAL-IPE--TPLRQSEFPN
sev_Dmel        SPPRNFSVRVLSPRELEVSWLPPEQLRS--ESVYYTLHWQQELDGENV--QDRREWEAHE
ROS_Mmus        GAVCHINATVLSDTSLHVFWTESHKPNGPKESVRYQLVMSYLAP-IPE--TPLRQGEFPS
ROS_Spur        -------------SEDKVFFV------------------------------------ETS
rol-3_Cele      SAPRDPHAIPVTPDTVYLYWNLPETLNAPISEIKYKISQQAAGISVPTSIAVIALSETVS
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        GRLTL-----L-------VTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMF-------
sev_Dmel        RRLETAGT-HR-------LTGIKPGSGYSLWVQA-HATPTKSNSSERLHVRSFAELPELQ
ROS_Mmus        AKLSL-----L-------ITKLSGGQLYVMKVLACHPEEMWCTESHPVSVNMF-------
ROS_Spur        GDLEI-----Y-------RSKLDGSDREE-------------------------------
rol-3_Cele      SNISSDTTSCLINPCRVKIANLRPSNEYKFWVTA----------THISHLDAATILKDDD
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        --------NTPEKPYSLVPEN---TSLQFNWKAPLNVN-LIRFWVELQKWKY-NEFYHVK
sev_Dmel        LLELGP------------------YSLSLTWAGTP-DP-LGSLQLECRSS---AE--QLR
ROS_Mmus        --------DTPEKPSALVPEN---TSLQLDWKARSNVN-LTGFWFELQKWKY-NEFYHVK
ROS_Spur        ------------------------------------------------------------
rol-3_Cele      AVSSEAVARTLDVPGTLRPDNVTGSSLLLRWNGLEPEHRPSSIAVQYRESGGANNEWQFP
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        TS--CS-QGPAYVCNITNLQPYTSYNVRVVVVYKTGE-----------NSTSLPESFKTK
sev_Dmel        RNVA----GNHTKMVVEPLQPRTRYQCRLLLGYAATPGA--------PLYHGTAEVYETL
ROS_Mmus        AS--CS-QGPVYVCNITDLQPYTSYNIRVVVVYTTGE-----------NSSSIPESFKTK
ROS_Spur        ------------LLELGNQQPYQAGFV---------------------------------
rol-3_Cele      MNVSFEPDVTTELVPITNLLSATSYDYRFVATYTGTYTIDGKVLAFKEDYLQLPQQARTK
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        AGVPNKPGIPKLLEGSKN--SIQWEK-AEDNGCRITYYILEIRKSTSNN--LQNQN-LR-
sev_Dmel        GDAPSQPGKPQLEHIAEEVFRVTWTA-ARGNGAPIALYNLEALQARSD---IRRRRRRRR
ROS_Mmus        AGVPSKPGIPKLLEGSKN--SIQWEK-AEDNGSRLMYYTLEVRKGISND--SQNQS-SR-
ROS_Spur        ---------------------IDWV-----------------------------------
rol-3_Cele      AGVPTAPQFVEAKQDEEG-WIVTWKEPMSDGGSPITSYAVETRINKTAEWEIAERGLDG-
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ----------------------WKMTFNGSCSSVCTWKSKNLKGIFQFRVVAAN-NLGFG
sev_Dmel        RNSGGSLEQLPWAEEPVVVEDQWLD-FCNTTELSCIVKSLHSSRLLLFRVRARSLEHGWG
ROS_Mmus        ----------------------WKVVFNGSCSSICTWRSKNLKGTFQFRAVAAN-EIGLG
ROS_Spur        -------------------------------SQILYWSDNS--AIYSF------------
rol-3_Cele      ----------------------WKTWWRPGKSDTTSSTSTSSTEVSEFRIRAAN-IEGFG
AqueK407_Aque   --------------------------------------RDN-------------------


ROS_Hsap        EYSGISENIILVGDDFWIPET--SFILTIIVGIFLVV-TIPLTFVWHRRLK--NQK----
sev_Dmel        PYSEESERVA---EPFVSPEKRGSLVLAIIAPAAIVS-SCVLALVLVRKVQ--KRRLRAK
ROS_Mmus        EYSEISEDITLVEDGVWITET--SFILTIIVGIFLVA-TVPLTFVWHRSLK--SHK----
ROS_Spur        -----------------------------------DT-TLPVSMAIMEEVYEAPEG----
rol-3_Cele      AYAYTEDKKEE-KEEEPSSVLPYLLLLSI---IFLLAAMILVACF---------------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        -SAK-------EGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPR
sev_Dmel        KLLQQSRPSIWSNLSTLQT-QQQLMAVRNR-----------AFSTTLSDADIALLPQINW
ROS_Mmus        -ASK-------EGLSVLNDNDKELAELRGLAAGVGLANACYAVHTVPTQEEIENLPAFPR
ROS_Spur        -NTV-------EGISV--NPHGK-MAIRQ-------ENSNY---------------AVTS
rol-3_Cele      ----------------------------------------------------WYLPVVNY
AqueK407_Aque   --------------------------------------------FKCTEEDLESLNKFPR
                                                                         .

ROS_Hsap        EKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS
sev_Dmel        SQLKLLRFLGSGAFGEVYEGQLKT--EDSEEPQRVAIKSLRKGASE--FAELLQEAQLMS
ROS_Mmus        EKLSLRLLLGSGAFGEVYEGTAIDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMS
ROS_Spur        EKLSLEHMSEHGSYKML-------------NVLILQLMTLRKGATDEDKQEFLKEATVMG
rol-3_Cele      STVTFNDYIDTCAYGIVHSGTAEEVPMSWEKDVRVAIKKLKPNHSFQEKMMFMKEAILLN
AqueK407_Aque   NKLRLENFIDRGEFGEVYQGTALDILGQGTGPTPVAVKTLRKGSTEDEQRKFLSEAALMS
                . : :        :  :                 : : .*: . :      ::.** ::.

ROS_Hsap        KFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGP----LLTLVDLVD
sev_Dmel        NFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQEPQPTAGLSLSELLA
ROS_Mmus        KFNHPNILKQLGVCLLGEPQYIILELMEGGDLLSYLRKARGTTFHGP----SLTLLDLVE
ROS_Spur        KFKHPNIVLLMGVCLDNDPQYIIQELMEGGDLLCYIRAARMPAPTNS----KITLMDQIE
rol-3_Cele      NLDHPNIVKELGVCITPGQELILLEYMEGGNLLKFLQKSTPNEYQSS----ELSPRDLLS
AqueK407_Aque   NFNHINIVKVLGVCLNNDPIYIIMELMPGGDLLKFLREARRD-HGPP----LLTQSELVQ
                ::.* **:  :*:*:      :: * * .*:** ::: :       .     ::  : :

ROS_Hsap        LCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYT--SPRIVKIGDFGLARDIYKNDYYR
sev_Dmel        MCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYR
ROS_Mmus        LCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYT--SPRVVKIGDFGLAREIYKNDYYR
ROS_Spur        IILDTVKGCEHLEELHFVHRDLAARNCLVSTKSYEA-HERVVKIGDFGLARDIYKNDYYR
rol-3_Cele      ISVDIARGMNYLERLPHVHKNLSARKCLLAGR------PGVTKL-EMGMSKELSNGQVNR
AqueK407_Aque   VALDVAQGCRYLEQQHFIHRDIAARNCLVSSKG----ADRVIKIGDFGLAKDLYSSDYYQ
                : :*  .*  :**   .:*::::.*:**::            *: ::*::::: ..:  :

ROS_Hsap        KRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQT
sev_Dmel        KEGEGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKE
ROS_Mmus        KRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQA
ROS_Spur        KEGEGLLPVRWMAPEGLMDGYFSVQSDVWAFGILMWEVMSRGQQPYPARSNVEVLRFVEA
rol-3_Cele      SDLENMEIVRWMAPEVLKDFQFSSKSDVWAYGVLLYEVFSFGEVPYGDKDNRRIMTDVRN
AqueK407_Aque   VEGQRKLPVRWMAPEALTQGKFSIESDVWSFGILLWEIMTFGNQPYPGRTNQEVLQFVTG
                   :    ****:** * :  *: :****::*:* :*::: *. **  : *  ::  *

ROS_Hsap        GGRLEPPRNCPD-DLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSI-YKSRDEAN
sev_Dmel        GGRLQQPPMCTE-KLYSLLLLCWRTDPWERPSFRRCYNTLHAISTDLRRTQM--AS----
ROS_Mmus        GGRLEPPRNCPD-DLWNLMSQCWAQEPDQRPTFHNIQNQLQLFRNVFLNNV-SHCGEAAP
ROS_Spur        GGRLSQPDQCPD-EIYMMMRRCWERSTEDRPSFKMLKEMIQDYRRKS-----------VG
rol-3_Cele      GSVLPIPSYCPSKRIYKVIKQCLTSDSTKRANFATILKIFETFRDDQKCQDD--KP-IQF
AqueK407_Aque   DGRLDKPEDCSS-RLYKLMQCCWKKYASERPKFAQIVDVISSYWDHLNNKRDSYCSDD--
                .. *  *  *..  :: ::  *    . .*..*    . :

ROS_Hsap        NSGVINESFEGEDGDVICLNSDDIMP----VALMET----------K-NRE-------GL
sev_Dmel        ----------ATAD-TVV------------------------------------------
ROS_Mmus        TGGVINKGFEGEDDEMVTLNSDDTMP----VALMET----------K-NQE-------GL
ROS_Spur        PNGADNFAFEGDG-KVDYSRLKDIPP--EMEDYLLPIDSKGDIIKDKPNIELPPDIDYDL
rol-3_Cele      NDGTDNTNFSASQD-STSSREPP-SPSHRMRDFIDT----------R-DLE-------PP
AqueK407_Aque   --------------------DDEEL-----EDILQR----------RPSRP-------SR


ROS_Hsap        NYMVLA-------------------------------TECGQGEEKSEGPLGSQESESCG
sev_Dmel        --------------------------------------SCSRPEFKVRFDG---------
ROS_Mmus        NYMVLA-------------------------------TKCSQGEGSYEGPLGPKELGSCD
ROS_Spur        AEKDLASASFKEEQKKEKRKGSKK--G-SLRGRLPGGASAADPTPRLEAAL---------
rol-3_Cele      SPSHLNQSFGGFEHPYEGERPATMWNGSGARNSAKNSIGRSMKKEKLRNPI---------
AqueK407_Aque   TSSVRSGFVNL----------------------ARQGSMRIRNSFRRRGSL---------
                                                               .

ROS_Hsap        LRKEEKEPHA----DK-----DFC------------------------------------
sev_Dmel        QPLEEHREHNERPEDE-----NL-------------------------------------
ROS_Mmus        LKKDKKQPQA----DK-----DFC------------------------------------
ROS_Spur        HDLENNRERGRDIDDQ-----RYLKY---------------------PVGSVSKATGAGV
rol-3_Cele      HSMDDLVARNQRPLSIHSEDTESTDYGASSSMYSPGSSNRISSQVDPPIGRLSSAPGIGI
AqueK407_Aque   HRKEEHDS----------------------------------------------------
                   :.

ROS_Hsap        ------------------------------QEKQV-------------------------
sev_Dmel        --------------TL---REVPLKDKQL-------------------------------
ROS_Mmus        ------------------------------QEPQV-------------------------
ROS_Spur        ANATDGAVGGATGPAVD----------DGSAEGAVGYSAGATMNGDAPNRTDLSNYAQAG
rol-3_Cele      VNDAFE----SSNPSLNLSRSWAGLSREVNQNPAGAGSS-----GTLPQ-----------
AqueK407_Aque   ------------------------------------------------------------


ROS_Hsap        ---------------------AYCPSGK--------PEGLNYACLTHSGYG-DGSD
sev_Dmel        ----------------------------------------------YANEG-VSRL
ROS_Mmus        ---------------------AYGSPGL--------SEGLNYACLAHSEHG-DVSE
ROS_Spur        KRHPNPFRANSMEELDGYDNLSFASSGAKASGGAKPSGGISVTGD-ITATD-YANV
rol-3_Cele      -------HTNSAGHLRL-PGVQVGAGGGRVYRNASGGGG-------PSNRGRISQV
AqueK407_Aque   -------------------------------------HGQNHAGL-NSE---EDLV
                                                               :