TIE2_Hsap       IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHP
TIE1_Hsap       ITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHP
TIE1_Mmus       ITFEDLIGEGNFGQVIRAMIKKDGLKMNAAIKMLKEYASENDHRDFAGELEVLCKLGHHP
TIE2_Mmus       IKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLGHHP
Tie_Spur        --------EGNFGQVMKATVKKDGGVIEVAVKTLKDGTSEADRKDFMGELEIMCKVGTHP
                        *******::* :****  ::.*:* :*: :*: *::** ****::**:* **

TIE2_Hsap       NIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIAN------STASTLS
TIE1_Hsap       NIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREH------GTASTLS
TIE1_Mmus       NIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRVLETDPAFAREH------GTASTLS
TIE2_Mmus       NIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIAN------STASTLS
Tie_Spur        NIVNLVGACEHQGILYVATEYARYGNLLNFLRSSRTIEADSPFPSSPTSRFKVNVSTSLT
                **:**:***:::* **:* *** :****:***.**.:*:*..*.         ..:::*:

TIE2_Hsap       SQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLSRGQEVYVKKTM
TIE1_Hsap       SRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTM
TIE1_Mmus       SRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSRGEEVYVKKTM
TIE2_Mmus       SQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYIAKIADFGLSRGQEVYVKKTM
Tie_Spur        AEQILGFAADVALGMQHLAQKGCVHRDLAARNILVCDNYVCKVTDFGLSRSDEVYVKTTA
                :.*:* **:*.* **::*::*  :********:** :*  .*::******.:*****.*

TIE2_Hsap       GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRL
TIE1_Hsap       GRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRM
TIE1_Mmus       GRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRM
TIE2_Mmus       GRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRL
Tie_Spur        GRLPVRWMAIESLNYSVYTTKSD-------------------------------------
                ********************:**

TIE2_Hsap       EKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
TIE1_Hsap       EQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
TIE1_Mmus       EQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQL
TIE2_Mmus       EKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSL
Tie_Spur        ----------------------------------V
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