TIE2_Hsap MDSLASLVLCGVSLLLSGTVE-GAMDLILINSLPLVSDAETSLTCIAS----GWRPH---
TIE1_Hsap MVWRVPPFLLP-ILFLASHVG-AAVDLTLLANLRLTDPQRFFLTCVSGEAGAGRGSDAWG
TIE1_Mmus MVWWGSSLLLP-TLFLASHVG-ASVDLTLLANLRITDPQRFFLTCVSGEAGAGRSSD---
TIE2_Mmus MDSLAGLVLCGVSLLLYGVVE-GAMDLILINSLPLVSDAETSLTCIAS----GWHPH---
Tie_Spur MGWIRGPCLLLFALIIAQYSRTNGEEIVIINSTPLVTGAVTRLVCLDA---SGQLSA---
* * *:: . :: :: . :. *.*: . * .
TIE2_Hsap EPITIGRDFEALMN-QHQDPLEVTQDVTREWAKKVV-WKREKASKINGAYFCEGRVRGEA
TIE1_Hsap PPLLLEKDDRIVRT-PPGPPLRLARNGS----HQVTLRGFSKPSDLVGVFSCVGGAGARR
TIE1_Mmus PPLLLEKDDRIVRTFPPGQPLYLARNGS----HQVTLRGFSKPSDLVGVFSCVGGAGARR
TIE2_Mmus EPITIGRDFEALMN-QHQDPLEVTQDVTREWAKKVV-WKREKASKINGAYFCEGRVRGQA
Tie_Spur DELSVQKVLPADEGL----PVPAAPSLVDPG-HLVADWNASWADSRYGVYSCHGLDE--A
: : : *: : . : *. . ... *.: * *
TIE2_Hsap IRIRTMKMRQQASFLPATLTMTVDKGDNVNISFKKVLIKE-EDAVIYKNGSF--IHSVPR
TIE1_Hsap TRVIYVHNSPGAHLLPDKVTHTVNKGDTAVLSARVHKEKQ-TDVIWKSNGSY--FYTLDW
TIE1_Mmus TRVLYVHNSPGAHLFPDKVTHTVNKGDTAVLSAHVHKEKQ-TDVIWKNNGSY--FNTLDW
TIE2_Mmus IRIRTMKMRQQASFLPATLTMTVDRGDNVNISFKKVLIKE-EDAVIYKNGSF--IHSVPR
Tie_Spur HKVMTVKINRDAQIKPEHFTMTASPGDNITITMQITTRTRTPDYLIWAHDELPLPYNATR
:: :: * : * .* *.. **. :: : .. * : :.. .
TIE2_Hsap HEVPD-ILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPECNHLCTA
TIE1_Hsap HEAQDGRFLLQLPNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCTKECPG
TIE1_Mmus QEADDGRFQLQLQNVQPPSSGIYSATYLEASPLGSAFFRLIVRGCGAGRWGPGCVKDCPG
TIE2_Mmus HEVPD-ILEVHLPHAQPQDAGVYSARYIGGNLFTSAFTRLIVRRCEAQKWGPDCSRPCTT
Tie_Spur FGFKD---RYSIPAVGQEDAGIYQA-YPPDDPTQGGYMRLIVRGCPAERWGTGCTNECPT
* : . .:*:*.* * . ..: ***** * * :**. * . *.
TIE2_Hsap CMNNGVCHEDTGECICPPGFMGRTCEKACELHTFGRTCKERCSGQEGCKSYVFCLPDPYG
TIE1_Hsap CLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGISGCRGLTFCLPDPYG
TIE1_Mmus CLHGGVCHDHDGECVCPPGFTGTRCEQACREGRFGQSCQEQCPGTAGCRGLTFCLPDPYG
TIE2_Mmus CKNNGVCHEDTGECICPPGFMGRTCEKACEPHTFGRTCKERCSGPEGCKSYVFCLPDPYG
Tie_Spur CSNGGECDDVTGVCVCPPGFHGDTCEIGCGANLYGSSCEHMCTGN-SCEHMQFCLPDPYG
* :.* *.: * *:***** * ** .* :* :*:. *.* .*. ********
TIE2_Hsap CSCATGWKGLQCNEACHPGFYGPDCKLRCSCNNGEMCDRFQGCLCSPGWQGLQCEREGIQ
TIE1_Hsap CSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDR-
TIE1_Mmus CSCGSGWRGSQCQEACAPGHFGADCRLQCQCQNGGTCDRFSGCVCPSGWHGVHCEKSDR-
TIE2_Mmus CSCATGWRGLQCNEACPSGYYGPDCKLRCHCTNEEICDRFQGCLCSQGWQGLQCEKEGRP
Tie_Spur CSCATGFAGLACDEACPDGHYGAGCLQTCHCENGGLCDPYAGCLCVGNWTGPTCEIKTCP
***.:*: * *:*** *.:*..* * * * ** : **:* .* * ** .
TIE2_Hsap RMT---------------------------------------------------------
TIE1_Hsap --I---------------------------------------------------------
TIE1_Mmus --I---------------------------------------------------------
TIE2_Mmus RMT---------------------------------------------------------
Tie_Spur DGTIYGSLCADSGECQNGGTCDPCLGCLCTEDLAGPTCQEKAFYFNTSHDVAMVDETRVQ
TIE2_Hsap ------------------------------------------------------------
TIE1_Hsap ------------------------------------------------------------
TIE1_Mmus ------------------------------------------------------------
TIE2_Mmus ------------------------------------------------------------
Tie_Spur LICGCTSAVPANQCPAFEIERFNPSNMIGMGEDYSFPTSTSLGLSFTPVGSIGNWNFRCR
TIE2_Hsap ---------------------PKIVDLPDHIEVNSGKFNPI-CKASGWPLPTNEEMTLVK
TIE1_Hsap ---------------------PQILNMASELEFNLETMPRINCAAAGNPFPVRGSIELRK
TIE1_Mmus ---------------------PQILSMATEVEFNIGTMPRINCAAAGNPFPVRGSMKLRK
TIE2_Mmus ---------------------PQIEDLPDHIEVNSGKFNPI-CKASGWPLPTSEEMTLVK
Tie_Spur PVDFRGQDTSLTLKVNVTGDPPRIMEFWLAEVVNLDQRAKFHCRVEGLSYQ-DVNVTLVT
*:* .: .* : * . * . .: * .
TIE2_Hsap PDGTVLHPKDFNHTDHFSVAIFTIHRILPPDSGVWVCSVNTVAGMVEKPFNISVKVLPKP
TIE1_Hsap PDGTVLLSTKAIVEPEKTTAEFEVPRLVLADSGFWECRVSTSGGQDSRRFKVNVKVPPVP
TIE1_Mmus PDGTMLLSTKVIVEPDRTTAEFEVPSLTLGDSGFWECRVSTSGGQDSRRFKVNVKVPPVP
TIE2_Mmus PDGTVLQPNDFNYTDRFSVAIFTVNRVLPPDSGVWVCSVNTVAGMVEKPFNISVKVLPEP
Tie_Spur PSSHVIESGELVGPTSSPTFLFSIPGVTKGDEGTYHCIADGITGSDQQECSLEVFVQPVP
*.. :: . . .. * : : *.* : * .. * .: .:.* * * *
TIE2_Hsap LNAPNVIDTGHNFAVINISSEPYFGDGPIKSKKLLYKPVNHYEAWQHIQVT-NE--IVTL
TIE1_Hsap LAAPRLLTKQSRQLVVS-PLVSFSGDGPISTVRLHYRPQDSTMDWSTIVVDPSE--NVTL
TIE1_Mmus LTAPRLLAKQSRQLVVS-PLVSFSGDGPISSVRLHYRPQDSTIAWSAIVVDPSE--NVTL
TIE2_Mmus LHAPNVIDTGHNFAIINISSEPYFGDGPIKSKKLFYKPVN--QAWKYIEVT-NE--IFTL
Tie_Spur VNSPIIVDTNSRAVEINLNIDEYTGDGPIQGVELQYKRVGG-DAWTPMTVSINEASAAVV
: :* :: . . :. : *****. .* *: . * : * .* .:
TIE2_Hsap NYLEPRTEYELCVQLVRRGEGGEGHPGPVRRFTTASI-GLPPPRGL-NLLPKSQTTLNLT
TIE1_Hsap MNLRPKTGYSVRVQLSRPGEGGEGAWGPPTLMTTDCPEPLLQPWLE-GWHVEGTDRLRVS
TIE1_Mmus MNLKPKTGYNVRVQLSRPGEGGEGGWGPSALMTTDCPEPLLQPWLE-SWHVEGPDRLRVS
TIE2_Mmus NYLEPRTDYELCVQLARPGEGGEGHPGPVRRFTTASI-GLPPPRGL-SLLPKSQTALNLT
Tie_Spur PNLVHNQDYEVRVVLWRRGSGGRGTYGPTTSLTTTCSRPTAEFWLRLTTPIEEWSSIELN
* . *.: * * * *.**.* ** :** . : :.:.
TIE2_Hsap WQ-PIFP--SSEDDFYVEVERRSVQ-KSDQQNIKVPGNLTS-------------------
TIE1_Hsap WSLPLVPGPLVGDGFLLRLWDGTRG-QERRENVSSPQART--------------------
TIE1_Mmus WSLPSVP--LSGDGFLLRLWDGARG-QERRENISFPQART--------------------
TIE2_Mmus WQ-PIFT--NSEDEFYVEVERRSLQTTSDQQNIKVPGNLTS-------------------
Tie_Spur WSQIRD-TGDELSGFRIEY-QKSGG-SVRTVEIPDSGTRTHKLTGLLANTHYTVILIPFN
*. . * :. : :: . *
TIE2_Hsap ------------------------------------------------------------
TIE1_Hsap ------------------------------------------------------------
TIE1_Mmus ------------------------------------------------------------
TIE2_Mmus ------------------------------------------------------------
Tie_Spur CGGDSVSTLSSATTRQGPPGPVGNFQLTVTSSDTITASWRIPEETRGDIVHYSIKVFEKV
TIE2_Hsap ------------------------------------------------------------
TIE1_Hsap ------------------------------------------------------------
TIE1_Mmus ------------------------------------------------------------
TIE2_Mmus ------------------------------------------------------------
Tie_Spur DGVVSDTAHWDDTTQNTVSQIFNLKPYTSYVVEVYARTVLVGEISRKEVTTKETAPSGPP
TIE2_Hsap ---------------------------------------------------------VLL
TIE1_Hsap ---------------------------------------------------------ALL
TIE1_Mmus ---------------------------------------------------------ALL
TIE2_Mmus ---------------------------------------------------------VLL
Tie_Spur STPSVIGQTMDTRMSFAWRPPPVDQRNGVIIVYEWNVMYVTTDGVYQSDVENVTETLATL
. *
TIE2_Hsap NNLHPREQYVVRARVNT-KAQGEWSEDLTAWTLSD-------------------------
TIE1_Hsap TGLTPGTHYQLDVQLYHCTLLGPASPPA-HVLLPP-------------------------
TIE1_Mmus TGLTPGTHYQLDVRLYHCTLLGPASPPA-HVHLPP-------------------------
TIE2_Mmus SNLVPREQYTVRARVNT-KAQGEWSEELRAWTLSD-------------------------
Tie_Spur TNLIPNRRYTFKVRAFTLEGPGPFTPSISHKTLTTEEAAKYLTTPPIAITVRGNPDLPNE
..* * :* . .: * : *.
TIE2_Hsap ------------------------------------------------------------
TIE1_Hsap ------------------------------------------------------------
TIE1_Mmus ------------------------------------------------------------
TIE2_Mmus ------------------------------------------------------------
Tie_Spur TGGRTGPSISENKASGGISSNTVLALGLVCVSIIIIVAIVFGGWMYKKRKTAGSVEFVAS
TIE2_Hsap ------------------------------------------------------------
TIE1_Hsap ------------------------------------------------------------
TIE1_Mmus ------------------------------------------------------------
TIE2_Mmus ------------------------------------------------------------
Tie_Spur IAGSEIGTYRFNEMQMRDIVDELSGFRIEYRKTGGSTMTVEIPDAGTRTHKLTGLLANTH
TIE2_Hsap ------------------------ILPPQPE-NIKISNITHSSAVISWTILDGY--SISS
TIE1_Hsap ------------------------SGPPAPR-HLHAQALSDSEIQLTWKHPEALPGPISK
TIE1_Mmus ------------------------SGPPAPR-HLHAQALSDSEIQLMWQHPEAPSGPISK
TIE2_Mmus ------------------------ILPPQPE-NIKISNITDSTAMVSWTIVDGY--SISS
Tie_Spur YTVIMTPFSCGGDSVSVQSSAETRQGPPGPVGNLQLIVKSSDRITANWRIPEETRGVIQS
** * ::: : . * : *..
TIE2_Hsap ITIR--YKVQGKNED-QHVDVKIKNATITQYQLKGLEPETAYQVDIFAE-----------
TIE1_Hsap YVVE--VQVAGGAGDPLWIDVDRPE--ETSTIIRGLNASTRYLFRMRAS-----------
TIE1_Mmus YIVE--IQVAGGSGDPQWMDVDRPE--ETSIIVRGLNASTRYLFRVRAS-----------
TIE2_Mmus IIIR--YKVQGKNED-QHIDVKIKNATVTQYQLKGLEPETTYHVDIFAE-----------
Tie_Spur YFIRVFEKVDGVVSDTALLD-RRSD--NTVFQIFDLKPYTSYVVEVYATTKHPSEGEISR
:. :* * * :* : * : .*:. * * . : *
TIE2_Hsap ------------------------------------------------------------
TIE1_Hsap ------------------------------------------------------------
TIE1_Mmus ------------------------------------------------------------
TIE2_Mmus ------------------------------------------------------------
Tie_Spur KEVTTKETAPSGPPSTPSVIGQTMDTRMSFAWHPPPVDQRNGVIIVYEWNVMYVTTDGVY
TIE2_Hsap --------------------------------NNIGSSNPAFSHELVTLP----------
TIE1_Hsap -------------------------------IQGLGDW--SNTVEESTLGNGLQA-----
TIE1_Mmus -------------------------------VQGLGDW--SNTVEEATLGNGLQS-----
TIE2_Mmus --------------------------------NNIGSSNPAFSHELRTLP----------
Tie_Spur QSDVENVTETLATLTNLIPNRRYTFKVRAFTLEGPGPFTPSISHN--TLTTEEAAKYLTT
:. * : : : **
TIE2_Hsap ------------------------ESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLII
TIE1_Hsap --------------------EGPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALLTL
TIE1_Mmus --------------------EGPVRESRAAEEGLDQQLVLAVVGSVSATCLTILAALLAL
TIE2_Mmus ------------------------HSPGSADLGGGKMLLIAILGSAGMTCITVLLAFLIM
Tie_Spur PPIAITARGNPDLPNETGGRTGPSISENKASGGISSNTVLA----LGLVCVSIIIIVAIV
. *. * .. ::* . .*:::: . :
TIE2_Hsap LQ---L-KR------------------------ANVQRRMAQAFQN-VREEPAVQFNSGT
TIE1_Hsap VC---I-RR------------------------SCLHRRRTFTYQSGSGEETILQFSSGT
TIE1_Mmus VC---I-RR------------------------SCLHRRRTFTYQSGSGEETILQFSSGT
TIE2_Mmus LQ---L-KR------------------------ANVQRRMAQAFQN-VREEPAVQFNSGT
Tie_Spur FGGWMYKKRKTAGSVEFVASIAGSEIGTYRFNEMLARQQSAQSATN-DYDENSRGLMLGA
. :* ::: : : . :* : *:
TIE2_Hsap LALNRKVKNNPDPTIYPVLDWNDIKFQD-VIGEGNFGQVLKARIKKDGLRMDAAIKRMKE
TIE1_Hsap LTLTRRPKLQPEPLSYPVLEWEDITFED-LIGEGNFGQVIRAMIKKDGLKMNAAIKMLKE
TIE1_Mmus LTLTRRPKPQPEPLSYPVLEWEDITFED-LIGEGNFGQVIRAMIKKDGLKMNAAIKMLKE
TIE2_Mmus LALNRKAKNNPDPTIYPVLDWNDIKFQD-VIGEGNFGQVLKARIKKDGLRMDAAIKRMKE
Tie_Spur MA--SPPGSPLPPIDYWRIPLDCLTLENFVIAEGNFGQVMKATVKKDGGVIEVAVKTLKD
:: * * : : :.::: :*.*******::* :**** ::.*:* :*:
TIE2_Hsap YASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRV
TIE1_Hsap YASENDHRDFAGELEVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSRV
TIE1_Mmus YASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSRV
TIE2_Mmus YASKDDHRDFAGELEVLCKLGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRV
Tie_Spur GTSEADRKDFMGELEIMCKVGTHPNIVNLVGACEHQGILYVATEYARYGNLLNFLRSSRT
:*: *::** ****::**:* ****:**:***:::* **:* *** :****:***.**.
TIE2_Hsap LETDPAFAIAN------STASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG
TIE1_Hsap LETDPAFAREH------GTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVG
TIE1_Mmus LETDPAFAREH------GTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVG
TIE2_Mmus LETDPAFAIAN------STASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVG
Tie_Spur IEADSPFPSSPTSRFKVNVSTSLTAEQILGFAADVALGMQHLAQKGCVHRDLAARNILVC
:*:*..*. ..:::*::.*:* **:*.* **::*::* :********:**
TIE2_Hsap ENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS
TIE1_Hsap ENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVS
TIE1_Mmus ENLASKIADFGLSRGEEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVS
TIE2_Mmus ENYIAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVS
Tie_Spur DNYVCKVTDFGLSRSDEVYVKTTAGRLPVRWMAIESLNYSVYTTKSDV------------
:* .*::******.:*****.* ********************:***
TIE2_Hsap LGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLN
TIE1_Hsap LGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLG
TIE1_Mmus LGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLG
TIE2_Mmus LGGTPYCGMTCAELYEKLPQGYRLEKPLNCDDEVYDLMRQCWREKPYERPSFAQILVSLN
Tie_Spur ------------------------------------------------------------
TIE2_Hsap RMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
TIE1_Hsap RMLEARKAYVNMSLFENFTYAGIDATAEE-A
TIE1_Mmus RMLEARKAYVNMSLFENFTYAGIDATAEE-A
TIE2_Mmus RMLEERKTYVNTTLYEKFTYAGIDCSAEEAA
Tie_Spur -------------------------------