Wnk4_Hsap MLASPATETTV--LMSQTEADLALRP-PPPLGT---AGQPR-----L------GPP----
Wnk3_Hsap MATDSGDPAST--EDSEKPDGISFEN-RVPQVAATLTVEAR-----LK------------
C46C2.1_Cele MTVICNRCRNISCRMSITNG--G-RP-PAPPSSVSSTTAST-----TG---NFGTR----
CG7177_Dmel MVLPPAPRN-----------------------LKGENTSIS-----SEEQTVQGANIQKS
Wnk1_Mmus MSDGAAEKQS------GTPGF--LTP-PAPVPKNGSSSDSS-----VGE--KLGAT----
Wnk2_Mmus MDGDGGRRD-A--PGALMEAG------------RGT-GSA--------------------
Wnk3_Mmus MATDSGEPAST--EDSEKPDGVSFEN-RAARAVAPLTVEAR-----IK------------
Wnk4_Mmus MLAPRNTETGV--PMSQTEADLALRP-SPALTS---TGPTR-----L------GPP----
Wnk1_Hsap MSGGAAEKQS------STPGSLFLSP-PAPAPKNGSSSDSS-----VGE--KLGAA----
Wnk2_Hsap MDGDGGRRD-V--PGTLMEPG------------RGA-GPA--------------------
17822_Tthe MMILKNRRIK--------------------------------------------------
8961_Tthe SDYS--------------------------------------------------------
WNK_Spur MSKSESHNSGS--SLSNGVASLEERDTDVPLKSHSSESVTK-----QGS--K-G-K----
AqueK219_Aque MTTSTQGQAVI--PEEPT-TNNHLNE-AQPISHQSSSSLLSKGLLVVGD--KIFPG----
WNK_e_Smoe MCCVMEVES---------------------------------------------------
WNK_a_Smoe MPASKP------------------------------------------------------
WNK_d_Smoe MTDKKPED-------HP-------------------------------------------
WNK_c_Smoe MTDKKPED-------HP-------------------------------------------
WNK_b-2_Smoe MRTGDGCQAEA--QLHQ-------------------------------------------
WNK_b-1_Smoe MRTGDGCQAEA--QLHQ-------------------------------------------
GK075_Glam MEIVAPLS------------------------VF------------------AGT-----
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele -RR-LVNRIKKVDE--------------------------------------LHPAQE--
CG7177_Dmel GHRSFNRSASSRQKPNPTSKLKDTLNRKPTCKQGTLSAHTSTSSTTSIQSSPIEPASSLP
Wnk1_Mmus -V-------------------------------------------------------A--
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap -A-------------------------------------------------------A--
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur -S-------------------------------------------------------G--
AqueK219_Aque -P-------------------------------------------------------A--
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam -----------QNQP---------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------NPTM---------------GSHWLS-----------------------------
CG7177_Dmel TLNTTPTPPAASKSNLFVRVLRRFSN---NTLPGKTASSPKNVDDVPKVNDNNNGDLGKQ
Wnk1_Mmus ------DSGV---------------G---RT-----------------------------
Wnk2_Mmus -------------------------G---MA-----------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------DAVT---------------G---RT-----------------------------
Wnk2_Hsap -------------------------G---MA-----------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ------DTQT---------------E---EA-----------------------------
AqueK219_Aque ------DVSS---------------L---AK-----------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------YPE---------------------------------------------------
Wnk4_Hsap ------------PRRAR-------------------------------------------
Wnk3_Hsap -----------------------------------------------EKNS---------
C46C2.1_Cele ----------EQERSRLEA---------------------------VQQDWRR-------
CG7177_Dmel QSTDVEVLCSQDNQSREQNEDEMDSKIEPADAISNQKAGLTSGKPKKDKSVKGTSQAVVS
Wnk1_Mmus ----------EEYRRRRHT---------------------------MDKDS---------
Wnk2_Mmus ----------E---------------------------------------P---------
Wnk3_Mmus -----------------------------------------------EKYS---------
Wnk4_Mmus ------------PRRVR-------------------------------------------
Wnk1_Hsap ----------EEYRRRRHT---------------------------MDKDS---------
Wnk2_Hsap ----------E---------------------------------------P---------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ----------EAADA---------------------------------------------
AqueK219_Aque ----------EDEQSGTHNL--------------------------PDVET---------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ---------R-------------FS----------GKAEPRP--RSSRLSRRSSVDLG--
Wnk3_Hsap ---------T-------------FS----------ASG-ETV--ERKRFFRKSVEMTE--
C46C2.1_Cele -------TRP-------------MK----------WTSKKRP--DDPTTSSPSTVSISNA
CG7177_Dmel DTKKMEARKSSSDTVIEPLIKQQAPLHSSKTTPTTLTA-NFV--QNIRFVRKNVEQSG--
Wnk1_Mmus ---------R-------------GA----------A-ATTTP--TEHRFFRRSVICDS--
Wnk2_Mmus ---------R-------------AR-------------AARL--GPQRFLRRSVVESD--
Wnk3_Mmus ---------T-------------FS----------ASG-ENI--ERKRFFRKSVEMTE--
Wnk4_Mmus ---------R-------------FS----------GKAEPRP--RSSRPSRRSSVDLG--
Wnk1_Hsap ---------R-------------GA----------A-ATTTT--TEHRFFRRSVICDS--
Wnk2_Hsap ---------R-------------AK-------------AARP--GPQRFLRRSVVESD--
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ---------------------------------------SHSGVNGESSMGNSVV-ISNR
AqueK219_Aque ---------M-------------GS-------------SS----------RPNGVIIENG
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe -------------------------------------QE---------------------
WNK_c_Smoe -------------------------------------QE---------------------
WNK_b-2_Smoe -------------------------------------CENR---SRSRFL----------
WNK_b-1_Smoe -------------------------------------CENR---SRSRFL----------
GK075_Glam -----------------------VE-----------------------------------
Wnk4_Hsap ---------LLS-SWSLPASP-A-----------------------PDPPDPP-------
Wnk3_Hsap ---------DDK-VA----------------------------------ESSPKDERIKA
C46C2.1_Cele LENSTPSLNNVS-SITNSSSP-FSL----SSAATSTASAIIPFTSNVATNHPHLNHH-VS
CG7177_Dmel ---------RNTNPLQFVELE-TEFPRDY------------------------DDNI-EM
Wnk1_Mmus ---------NAT-ALELPGLP-LSIPQPSVPA-------VVP---QSAPPEPHREET-LT
Wnk2_Mmus ---------QEE----PPGLE---------AA-------ETP---SAQPPQPLQRRV-LL
Wnk3_Mmus ---------DDK-VA----------------------------------ESSRRDER-KA
Wnk4_Mmus ---------LLS-SWSQPASL-L-----------------------PEPPDPP-------
Wnk1_Hsap ---------NAT-ALELPGLP-LSLPQPSIPA-------AVP---QSAPPEPHREET-VT
Wnk2_Hsap ---------QEE----PPGLE---------AA-------EAP---GPQPPQPLQRRV-LL
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur R------------------SPNFSD-----------------TDVNVESFHN--------
AqueK219_Aque GETNVHFVS---------------------------------SKEEVLPTEPEKQK----
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -------------------------------------DSAGPGPA--RSPPPS-------
Wnk3_Hsap AMNI----PR-------------VDKLPSN-VLRGGQ-----------------------
C46C2.1_Cele RIPQ----AIVTGGTNGSLPPLLISPTSAAAATPLISGKAGPMSP--STGSPINVAATVL
CG7177_Dmel LSREAEHLEE-------------QFRTPTRS-----------------------------
Wnk1_Mmus ATVA----SQ-------------VSQQPSAAASPGEQAVVGSATT--TVPSST-------
Wnk2_Mmus LCKTRRLIAE-------------RARGRPAAPAPAAP-AAPPGSP--SVPSDP-------
Wnk3_Mmus ATNI----SR-------------VDKVPTN-VLRGGQ-----------------------
Wnk4_Mmus -------------------------------------DSAG--PT--RSPPSS-------
Wnk1_Hsap ATAT----SQ-------------VAQQPPAAAAPGEQAVAGPAPS--TVPSST-------
Wnk2_Hsap LCKTRRLIAE-------------RARGRPAAPAPAAL-VAQPGAP--GAPADA-------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur --------DK-------------VTENSES-AADTKHTVISDESS--TTGYSS--RLDSI
AqueK219_Aque -------------------------------------QDGGPVGGGVTPPI--QDSQDGV
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ----------------------------------------------------------SK
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele QNAVSSPQHS-----------------------------------------IFDRSRLNK
CG7177_Dmel ---------NATDATSHHVAGIIDNIITEASRSLTIEKTEDDVPLKSSTKHS--------
Wnk1_Mmus ----------------------------------------------------------SK
Wnk2_Mmus ----------------------------------------------------------GP
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ----------------------------------------------------------SK
Wnk1_Hsap ----------------------------------------------------------SK
Wnk2_Hsap ----------------------------------------------------------GP
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur G-------D---------------------------------------------KELLKE
AqueK219_Aque K-------KK-----------------------------------------VLETLEVEE
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap EPPE------GTW-TEGAPVKAA------------------------------------E
Wnk3_Hsap ------------------EVKY--------------------------------------
C46C2.1_Cele IPPN------TSLASSSSPSDAA---NNDKPIQQRHS-----ILSNVRTLTQAMVNDGPR
CG7177_Dmel --S-------GVK---------------------RVGFQVEDK-----------------
Wnk1_Mmus DRPV------S----QPSLVGS-------------------------------------K
Wnk2_Mmus ERAG-------TQEPSPDPTTAS---AAAAQV----------------------PDGGPR
Wnk3_Mmus ------------------EVKY--------------------------------------
Wnk4_Mmus EPPE------GTW-MGAAPVKAV-------------------------------------
Wnk1_Hsap DRPV------S----QPSLVGS-------------------------------------K
Wnk2_Hsap EPVG-------TQEPGPDPIAAA---VETAPA----------------------PDGGPR
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur KVPDTSVHLANSH-PNGTALKSARKDSNMKPERGRIA-------------------SGNG
AqueK219_Aque HIV-------NTS-PTGRFVKYE---Q---EI-GRGSFKTVYKG----------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------DSARPELPDSAVG------PGSREPLRVP---EAVALER----RREQ-------
Wnk3_Hsap -----------------EQ--------CSK--STS---EISKDCFK--EKNEK-------
C46C2.1_Cele -----------TLT--GDD------M--DK--MVS----EEERARK--EQEKREEEEKA-
CG7177_Dmel --------------------------DDTE--VQSEKQAKS-----FDDITKKAESSEAS
Wnk1_Mmus ------EEPPPSRS--GSG------SGGA----SA---KEAQEDR----SQQQ-------
Wnk2_Mmus ------QEEAPAPTQEDA--------GTTE--AKP----EPGRARK--DEPEE-------
Wnk3_Mmus -----------------EQ--------CSK--ATS---ESSKDCFK--EKTEK-------
Wnk4_Mmus ------DSACPELTGSSGG------PGSREPPRVP---DAAARER----RREQ-------
Wnk1_Hsap ------EEPPPARS--GSG------GG------SA---KEPQEER----SQQQ-------
Wnk2_Hsap ------EEAAATVRKEDE--------GAAE--AKP----EPGRTRR--DEPEE-------
17822_Tthe -------------------------------------------------SLKKV------
8961_Tthe -------------------------------------------------DRDE-------
WNK_Spur KKQKSVVIMAPVKDITENGHIEVHKEEKVEPLQIH---EMHDSERRLLIETEE-------
AqueK219_Aque ---------LDTE----TG------VAVAW--CEL---LDSQDGI----KKKV-------
WNK_e_Smoe ---------------------------------------------------GA-------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe -------------------------------------------ARN--ESKSG-------
WNK_c_Smoe -------------------------------------------ARN--ESKSG-------
WNK_b-2_Smoe ------------------------------------------ASRM---SSQL-------
WNK_b-1_Smoe ------------------------------------------ASRM---SSQL-------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -----------------------------------EEKEDMETQAVA-------------
Wnk3_Hsap -----------------------------------EMEEEAEMKAVA-------------
C46C2.1_Cele -----------------------------ARRIDVEDDFDAQEKPID-------------
CG7177_Dmel AEEAAVTGSSTDASASPLPSTSLVSTTSSATS-ITKSKSDEDDDPVA-------------
Wnk1_Mmus -----------------------------------DDIEELETKAVG-------------
Wnk2_Mmus -----------------------------------EEDDEDDLKAVA-------------
Wnk3_Mmus -----------------------------------EMEEEAEMKAVA-------------
Wnk4_Mmus -----------------------------------EEKEDTETQAVA-------------
Wnk1_Hsap -----------------------------------DDIEELETKAVG-------------
Wnk2_Hsap -----------------------------------EEDDEDDLKAVA-------------
17822_Tthe -----------------------------------LKEDLFEQELVQYYYWKIFIFKAIV
8961_Tthe -----------------------------------NEDNDYKDRIAE-------------
WNK_Spur -----------------------------------AEPEAVEEKAIA-------------
AqueK219_Aque -----------------------------------LETLEVEEHIVN-------------
WNK_e_Smoe -----------------------------------NAADADDSEFVE-------------
WNK_a_Smoe -----------------------------------GAESDTGSEFVE-------------
WNK_d_Smoe -----------------------------------KEGEDEEAEFVE-------------
WNK_c_Smoe -----------------------------------KEGEDEEAEFVE-------------
WNK_b-2_Smoe -----------------------------------DLGSEDEAEFVE-------------
WNK_b-1_Smoe -----------------------------------DLGSEDEAEFVE-------------
GK075_Glam -----------------------------SSP-LRNEGVYYNPFSDT-------------
Wnk4_Hsap -----------------TSPDGRYLKFDI-EIGRGSFKTVYRGLDTDTTVEVAWCELQTR
Wnk3_Hsap -----------------TSPSGRFLKFDI-ELGRGAFKTVYKGLDTETWVEVAWCELQDR
C46C2.1_Cele -----------------KSKNGRFLKFDE-ELGRGSFKTVFRGLDTETGVAVAWCELQES
CG7177_Dmel -----------------MSPCGRFFKYDK-EVGRGSFKTVYRGLDTLTGVPVAWCELLDK
Wnk1_Mmus -----------------MSNDGRFLKFDI-EIGRGSFKTVYKGLDTETTVEVAWCELQDR
Wnk2_Mmus -----------------TSLDGRFLKFDI-ELGRGSFKTVYKGLDTETWVEVAWCELQDR
Wnk3_Mmus -----------------TSPSGRFLKFDI-ELGRGAFKTVYKGLDTETWVEVAWCELQDR
Wnk4_Mmus -----------------TSPDGRYLKFDI-EIGRGSFKTVYRGLDTDTTVEVAWCELQTR
Wnk1_Hsap -----------------MSNDGRFLKFDI-EIGRGSFKTVYKGLDTETTVEVAWCELQDR
Wnk2_Hsap -----------------TSLDGRFLKFDI-ELGRGSFKTVYKGLDTETWVEVAWCELQDR
17822_Tthe SCHYSFISTKFHQNTNQIFLQIIKIKFNE-ELGFGAYKTVYKGYDNDSGCEIAWNVIKLQ
8961_Tthe -----------------TSPKGRFIRFNE-ELGFGAYKTVYRAYDNDSGCEVAWNVIKLQ
WNK_Spur -----------------KSADGRFMKYDV-AVGQGSFKTVFRGLDTETGVAVAWCELQER
AqueK219_Aque -----------------TSPTGRFVKYEQ-EIGRGSFKTVYKGLDTETGVAVAWCELLEH
WNK_e_Smoe -----------------VDPTGRYGRYNE-VLGRGAFKTVYKAFDEVDGIEVAWNQVNVQ
WNK_a_Smoe -----------------IDPTGRYGRYSE-VLGKGAFKAVYRAFDEVDGLEVAWNQVNVQ
WNK_d_Smoe -----------------RDPTGRYGRYNE-ILGKGAFKTVYRAFDEVDGIEVAWNQVKVE
WNK_c_Smoe -----------------RDPTGRYGRYNE-ILGKGAFKTVYRAFDEVDGIEVAWNQVKVE
WNK_b-2_Smoe -----------------VDPTGRYGRYKE-LLGKGAFKTVYKAFDEIDGIEVAWNQVKLH
WNK_b-1_Smoe -----------------VDPTGRYGRYKE-LLGKGAFKTVYKAFDEIDGIEVAWNQVKLH
GK075_Glam -----------------LGPSDRYLKYSGDVLGKGAFKTVYRAFDLIAGREVAWNEVVLD
::. :* *::*:*::. * :** :
Wnk4_Hsap KLS--RAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKT
Wnk3_Hsap KLT--KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESIL--KGKKCIVLVTELMTSGTLKT
C46C2.1_Cele KLN--KTERQRFREEAEMLKDLQHPNIVRFYDYWESADLCGKRKYIVLVTELMTSGTLKM
CG7177_Dmel QVK--KSERTRFREEADMLKKLQHPNIVRFYTYWEFPI--GRKKNIVLVTELMLSGTLKS
Wnk1_Mmus KLT--KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKT
Wnk2_Mmus KLT--KLERQRFKEEAEMLKGLQHPNIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKT
Wnk3_Mmus KLT--KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTL--KGKKCIVLVTELMTSGTLKT
Wnk4_Mmus KLS--RAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKT
Wnk1_Hsap KLT--KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKT
Wnk2_Hsap KLT--KLERQRFKEEAEMLKGLQHPNIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKT
17822_Tthe RLP--Q--------------------------------------------QCLSGGSLK-
8961_Tthe RLP--LNERKRISEEIQLLKNLHHPNIINFINAWINKS----KNEVIFITECVSGGSLKK
WNK_Spur KLS--RSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSP-RGKKHIVLVTELMTSGTLKT
AqueK219_Aque KFN--KEEQSRFKEEVAILKTLNHPYILRLFDSWEFVRQSDKKRVLVLITELMTSGTLKS
WNK_e_Smoe DVLGRPEDLERLYSEVHLLRGLKHKNVIKFFTSWVDPR----TKNVNFITEIFTSGTLRQ
WNK_a_Smoe DLLRSPDDLERLYSEVHLLKTLKHKNIIKFYTSWVDSK----RRNVNFITEIFTSGTLRQ
WNK_d_Smoe DVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQ
WNK_c_Smoe DVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQ
WNK_b-2_Smoe DVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDTK----NNNVNFITEIFTSGNLRQ
WNK_b-1_Smoe DVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDTT----SNNVNFITEIFTSGNLRQ
GK075_Glam TLE--PMASSKLFQEIKALKDVDHENIIKLYDHWFE-----GSNLLIFTTELMPSGCLKK
. : . .* *:
Wnk4_Hsap YLRRFR-EMKPRV-LQRWSRQILRGLHFLHSRVP-PILHRDLKCDNVFITGPTGSVKIGD
Wnk3_Hsap YLKRFK-VMKPKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
C46C2.1_Cele YLKRFK-RINIKVVLKSWCRQILKGLSFLHTRNP-PVIHRDLKCDNIFITGTTGSVKIGD
CG7177_Dmel YLKRFK-KIHPKV-LKSWCRQILKGLNFLHTRQF-PIIHRDLKCDNIFITGTTGSVKIGD
Wnk1_Mmus YLKRFK-VMKIKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk2_Mmus YLKRFK-VMKPKV-LRSWCRQILKGLLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk3_Mmus YLKRFK-VMKPKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk4_Mmus YLRRFR-EMKPRV-LQRWSRQILRGLHFLHSRVP-PILHRDLKCDNVFITGPSGSVKIGD
Wnk1_Hsap YLKRFK-VMKIKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk2_Hsap YLKRFK-VMKPKV-LRSWCRQILKGLLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
17822_Tthe ---KIK-KPRLKI-IKQWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGD
8961_Tthe HLKKIK-KPRLKI-IKNWCRQILKGLVYLHEQKPYPIIHRDIKCENVFISTTNNEIRIGD
WNK_Spur YLKRFK-GVKNRV-LRSWCRQILKGLHFLHTRQP-PIIHRDLKCDNIFITGTSGAVKIGD
AqueK219_Aque YMRRFK-SIKPRV-IRSWGRQILRGLSFLHTRTP-PIIHRDLKCDNVFINGTTGLVKIGD
WNK_e_Smoe YRKKHK-NVDMKA-VKNWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNQGEVKIGD
WNK_a_Smoe YRKKHK-NVDMKA-VKNWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNYGEVKIGD
WNK_d_Smoe YRKKHK-HVDMRA-VKNWAKQILRGLLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGD
WNK_c_Smoe YRKKHK-HVDMRA-VKNWAKQILRGLLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGD
WNK_b-2_Smoe YRRKHK-HVDLKA-VKHWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGD
WNK_b-1_Smoe YRRKHK-HVDLKA-VKHWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGD
GK075_Glam YLKKNPTALTTPV-LKSWALQILEALNYMHTCQP-KIIHRDIKAQNIFINGATGVVKVGD
: :: * *** .* ::* ::***:*.:*:*:. . :::**
Wnk4_Hsap LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSEC
Wnk3_Hsap LGLA-TL-MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
C46C2.1_Cele LGLA-TL-KNKSFAKSVIGTPEFMAPEMYE-EMYDESVDVYAFGMCLLEMVTGEYPYSEC
CG7177_Dmel LGLA-TL-KNRSHAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMAISEYPYSEC
Wnk1_Mmus LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk2_Mmus LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk3_Mmus LGLA-TL-MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk4_Mmus LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSEC
Wnk1_Hsap LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk2_Hsap LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
17822_Tthe LGLA-LT-LKSDFTTSVLGTPEFMAPEIYE-EKYGTAVDIYAFGMCLLEMATLQIPYREC
8961_Tthe LGLA-VSLKNSSHTKSVIGTPEFMAPEIYE-EKYGTPVDIYSFGMCVLEMATLSTPYKEC
WNK_Spur LGLA-TL-KKSSFAKSVIGTPEFMAPEMYE-EHYDEAVDVYAFGMCLLEMATSEYPYAEC
AqueK219_Aque LGLA-TL-KRS-DVKTVIGTPEFMAPEMYD-EVYDESVDVYAFGMCLLEMCTLEYPYQEC
WNK_e_Smoe LGLA-TILRQAHAAHSVIGTPEFMAPELYE-EDYNELVDIYAFGMCVLELVTFDYPYSEC
WNK_a_Smoe LGLA-TILRQAHAAHSVIGTPEFMAPELYE-EEYDELVDIYSFGMCVLEMVTFEYPYSEC
WNK_d_Smoe LGLA-AILRQAHAAHSVIGTPEFMAPELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSEC
WNK_c_Smoe LGLA-AILRQAHAAHSVIGTPEFMAPELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSEC
WNK_b-2_Smoe LGLA-GILRQAHGAHSVIGTPEFMAPELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSEC
WNK_b-1_Smoe LGLA-GILRQAHGAHSVIGTPEFMAPELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSEC
GK075_Glam LGLCASL-GLQSTAVSCIGTPEFMAPETYSNAHYDEKVDIYAFGMLLLELITRDTPYLEC
***. . : :********* *. *. **:*:*** :**: . ** **
Wnk4_Hsap QNAAQIYRKVTSGRKPNSFHKV--KIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREER
Wnk3_Hsap QNAAQIYRKVTSGIKPASFNKV--TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT
C46C2.1_Cele MNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFFTPED
CG7177_Dmel KGPAQIYKKVISGIKPAALAKV--EDPNVRDIIERCIELKKEDRPSCNELLESEFFDEDI
Wnk1_Mmus QNAAQIYRRVTSGVKPASFDKV--AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET
Wnk2_Mmus QNAAQIYRKVTCGIKPASFEKV--HDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDT
Wnk3_Mmus QNAAQIYRKVTSGIKPASFNKV--TDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDT
Wnk4_Mmus QNAAQIYRKVTSGTKPNSFYKV--KMPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREER
Wnk1_Hsap QNAAQIYRRVTSGVKPASFDKV--AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET
Wnk2_Hsap QNAAQIYRKVTCGIKPASFEKV--HDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDT
17822_Tthe TSAAQVYKKVSQGLLPNSLQLI--QNDSLKQFILKCIQR-SENRPSAAQLLQDDFFKESE
8961_Tthe TSAAQVYKKVSQGILPYQIDLI--QNEGLKNLILKCLSH-YKDRPSAEELLNDKFLDMSE
WNK_Spur SNAAQIYRRVTTGVKPQSFEKV--NDNKIKEIIDGCTKTNNTERYLIQELLKHTFFED-T
AqueK219_Aque SNPAQIYKKVTSGVMPNSLNKV--NDPMLKEIIVACTKLSKSARYTVEMLLNHEFFAEGD
WNK_e_Smoe TNAAQIYKKVSSGIKPAALDKV--KDPEVRSFIQKCLAT-ASKRLPARELLKDPFLQCES
WNK_a_Smoe TNAAQIYKRVTSGKKPAAFEKV--KDPEVRKFIEKCLAA-VSRRLPARELLMDPFLRCDG
WNK_d_Smoe TNAAQIYKKVTSGKKPAALDRV--KDLEVRAFIEKCLAT-VSKRLPARELLMDPFLQSED
WNK_c_Smoe TNAAQIYKKVTSGKKPAALDRV--KDLEVRAFIEKCLAT-VSKRLPARELLMDPFLQSED
WNK_b-2_Smoe MNAAQIYKKVTSGKKPAALNKV--QDPQMRAFVEQCLAK-ACRRLPARELLMDPFLQCHT
WNK_b-1_Smoe MNAAQIYKKVTSGKKPAALNKV--QDPQMRAFVEQCLAK-ACRRLPARELLMDPFLQCHT
GK075_Glam ANIVDVLKKVEGNIPPNGLNKV--VHKEMKDLILLCINKDPSARPSARELLSKPFLSNMS
. . : ::* . * : : :: :: * * ** *:
Wnk4_Hsap --GVH---VELAEEDDG------------E------------------------------
Wnk3_Hsap --GLR---VELAEEDDC------------S------------------------------
C46C2.1_Cele LIGIR---VEIKNRDAD------------LNDL---------------------------
CG7177_Dmel --GIR---VEPTASEQF-----------LSDPS---------------------------
Wnk1_Mmus --GVR---VELAEEDDG------------E------------------------------
Wnk2_Mmus --GVR---VELAEEDHG------------R------------------------------
Wnk3_Mmus --GLR---VELAEEDDC------------S------------------------------
Wnk4_Mmus --GVH---VELAEEDDG------------E------------------------------
Wnk1_Hsap --GVR---VELAEEDDG------------E------------------------------
Wnk2_Hsap --GVR---VELAEEDHG------------R------------------------------
17822_Tthe I---DNQPIQLASDR---------------IPQ---------------------------
8961_Tthe Q-DEDNYPVQLLDAS---------------NAS---------------------------
WNK_Spur --AFR---VDIVHDDN--------------------------------------------
AqueK219_Aque ---VK---VEVMTEPTP------------AD-----------------------------
WNK_e_Smoe D--RDGVADSLPSLNKD---------RVN---DMEEL---------PSRNPYSEFKDDTQ
WNK_a_Smoe E---RESLE--------CIPVIRKQSRVD---DMEELRSSAVTNHE----SDQGDSDQQR
WNK_d_Smoe R--EPLDPEQ-SQTDS-------------DQGGLGSYQKGV------------SFREEGK
WNK_c_Smoe R--EPLELVP-PISRS--------TSRADDMEGLST------------------------
WNK_b-2_Smoe A--ERGVVHE-PHNSMDELEVILEEN---GDDSLSTIHAGAMAYDLAPRGAHHNHHELTR
WNK_b-1_Smoe A--ERGVVHE-PHDSMDELEVILEEN---GDDSLSTIHAGAMAYDLAPRGAHHNHHELTR
GK075_Glam --DTG-K-LTTDAKDHG-----------P-SAQ---------------------------
Wnk4_Hsap -------------K----------PGLKLWLRMEDA-------------R-RG-GRPRDN
Wnk3_Hsap -------------N----------SSLALRLWVEDP-------------KKLK-GKHKDN
C46C2.1_Cele -------------N----------VEIQMQLRVYDE-------------KKRKQYRFKEN
CG7177_Dmel -------------I----------SIIEFRLRFMDP-------------KKRS-SRHKEN
Wnk1_Mmus -------------K----------IAIKLWLRIEDI-------------KKLK-GKYKDN
Wnk2_Mmus -------------K----------STIALRLWVEDP-------------KKLK-GKPKDN
Wnk3_Mmus -------------N----------SSLALRLWVEDP-------------KKLK-GKHKDN
Wnk4_Mmus -------------K----------PGLKLWLRMEDA-------------R-RG-GRPRDN
Wnk1_Hsap -------------K----------IAIKLWLRIEDI-------------KKLK-GKYKDN
Wnk2_Hsap -------------K----------STIALRLWVEDP-------------KKLK-GKPKDN
17822_Tthe ------SLGNSNDS---------------------P--------------Q-------TN
8961_Tthe ------------------------------------------------------------
WNK_Spur -------------K----------DQIQLQLRVEDP-------------KKRR-ERHRDN
AqueK219_Aque -------------------------SVMVRLVVPRT-------------SK-E-NKKNEQ
WNK_e_Smoe KSKDFKVKGKLRQ-----------DNIFLRLRISEQ--------------G-------HV
WNK_a_Smoe KSIDFKVKGRRRED----------DTIFLRLRIADP-------------EG-------HI
WNK_d_Smoe RSRDFRVKGKKKDD----------DTIFLRVRIADL-------------EG-------HV
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe RSRDFRVRVRRRND----------DTIFLKLRIADQ-------------EG-------CI
WNK_b-1_Smoe RSRDFRVRVRRRND----------DTIFLKLRIADQ-------------EG-------CI
GK075_Glam -------------VSLGTHEQTMQSTGHTAVNAAQTALKLPQQSSLPISSPRG-PQQSH-
Wnk4_Hsap QAIEFLFQLGRDAAEEVAQEMVALGL-------------------------VCE--ADYQ
Wnk3_Hsap EAIEFSFNLETDTPEEVAYEMVKSGF-------------------------FHE--SDSK
C46C2.1_Cele EGLQFAFDIENDSPDEVVQQMIEQQH-------------------------IPD--EDTR
CG7177_Dmel EAIQFEYNIRHDEYEQIAQEMMKENI-------------------------ISE--DDSR
Wnk1_Mmus EAIEFSFDLERDVPEDVAQEMVESGY-------------------------VCE--GDHK
Wnk2_Mmus GAIEFTFDLEKETPDEVAQEMIDSGF-------------------------FHE--SDVK
Wnk3_Mmus EAIEFSFNLEADTPEEVAYEMVKSGF-------------------------FHE--SDSK
Wnk4_Mmus QAIEFLFQLGRDAAEEVAQEMVALGL-------------------------VCE--ADYQ
Wnk1_Hsap EAIEFSFDLERDVPEDVAQEMVESGY-------------------------VCE--GDHK
Wnk2_Hsap GAIEFTFDLEKETPDEVAQEMIESGF-------------------------FHE--SDVK
17822_Tthe H-QQQSFQQNQDQHSQVQSSNFKKTS-------------------------DFE--SPIH
8961_Tthe --TPMNYTLSNSCPLESAQVFQLKGQKNTEASPCTDQNQNNEIQSQEIHSDNLK--DNMF
WNK_Spur EALQFEIDLNKDEPDQVAKEMVRIGF-------------------------VSE--EDSK
AqueK219_Aque ESIEFAYNLQTDIPEDIVNDMVKSGI-------------------------LRE--EDKK
WNK_e_Smoe RNIHFAFDLEADTAFSVASEMVTELD-------------------------LSD--QDVA
WNK_a_Smoe RNIHFPFDVEGDTALSVASEMVAELD-------------------------LSD--QDVT
WNK_d_Smoe RNIHFPFSIEGDTAMSVASEMVAELD-------------------------LSD--QDVT
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe RNIHFPFDVEADTALCVASEMVAELD-------------------------LSD--QDVT
WNK_b-1_Smoe RNIHFPFDVEADTALCVASEMVAELD-------------------------LSD--QDVT
GK075_Glam ----IPQSL--SKPVCPASMGVSVVN-------------------------VAVPTTAVT
Wnk4_Hsap PVARAVRE----RVAAIQRK----RE---KLR-KAR----ELEALPP------E------
Wnk3_Hsap AVAKSIRD----RVTPIKKT----RE---KKP-AG-----CLEERRD------SQCKSM-
C46C2.1_Cele MITKLIKD----KVDAFRRD----RD---HRL-LEIKRAKEEEERIR-------EEAEIK
CG7177_Dmel AVARLLKV----QVVSLLKE----RA---QRQ-TQIKL---QNEKSR------LEKLALQ
Wnk1_Mmus TMAKAIKD----RVSLIKRK----RE---QRQ-LVR----EEQEKRK------QEESSFK
Wnk2_Mmus IVAKSIRD----RVALIQWR----RE---RIW-PAL----QSQEPKD------SGSPDKA
Wnk3_Mmus AVAKSIRD----RVTLIKKI----RE---KKP-AG-----CLEERRD------SQCKYV-
Wnk4_Mmus PVARAVRE----RVAAIQRK----RE---KLR-KAR----ELEVLPP------D------
Wnk1_Hsap TMAKAIKD----RVSLIKRK----RE---QRQ-LVR----EEQEKKK------QEESSLK
Wnk2_Hsap IVAKSIRD----RVALIQWR----RE---RIW-PAL----QPKEQQD------VGSPDKA
17822_Tthe QVSQKQDNNSSSSASKSSHS----KQHRGSNQAS----------------P-AQSQNS-S
8961_Tthe -IPRKQSNFSDKKTTSLSHK----KK---KNQLTI-----DVTEYDFDEVN-KQQQLALQ
WNK_Spur AVTKVIRD----RIGTVWKN----RE---KRE-KER----QEKGKLE------EDKDSKA
AqueK219_Aque NAIRSVRE----LTDPLTDPAKQKRQ---QKP-A-A----TAGATAP------HG-----
WNK_e_Smoe TIAEMIDA----EILSLVPD----WK---P---GG-----AFDADDEKG---VEDTGPV-
WNK_a_Smoe TIAEMIDA----EILNLVPD----WK---P---GA-----AFDESGGDGENNYIDGDDM-
WNK_d_Smoe TIAEMIDA----AIVALVPD----WR---P---GA-----SFEDNGVTE---VDDQAQA-
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe TIADMIDA----EIVLLVPH----WR---P---GA-----SFEEHREDTI--LHDTDDI-
WNK_b-1_Smoe TIADMIDA----EIVLLVPH----WR---P---GA-----SFEEHREDTT--LHDTDDI-
GK075_Glam ---------------NSLSH----VL---ASE--TVST---DQSGSI------L------
Wnk4_Hsap ---PGPPPA---------------TVPMAPG--P---PSVFPPEPEEPEADQH-------
Wnk3_Hsap -GNVFPQPQ-------------NTTLPLA----P---AQQTGAECEETEVDQH-------
C46C2.1_Cele E--ELRLRAEAKEKEKERLEKERLEKKAAAAAAANPNPTPIPPTPATPHSSAQ-------
CG7177_Dmel K--QRE------------------SLP----TN----VDEDEEEEEESEDEEDGVKWNQR
Wnk1_Mmus Q--QNEQQASVSQAGIQQLSAASTGIPTAPATSA---SVSTQVEPEEPEADQH-------
Wnk2_Mmus RGLPAPLQV-------------QVTYH----AQS---GQPGQPEPEEPEADQH-------
Wnk3_Mmus -RNVLPQQQ-------------TATLQPT----P---GPHTAAEYEETEVDQH-------
Wnk4_Mmus ---SGPPPA---------------TVSLAPG--P---PSAFPPEPEEPEADQH-------
Wnk1_Hsap Q--QVEQS-SASQTGIKQLPSASTGIPTASTTSA---SVSTQVEPEEPEADQH-------
Wnk2_Hsap RGPPVPLQV-------------QVTYH----AQA---GQPGPPEPEEPEADQH-------
17822_Tthe Q---------------------------------------SSEKPAQQNLTQN-------
8961_Tthe Q---------------------------------------QQEKQIQQDLVQV-------
WNK_Spur -----DAGTSTTDSGMGFSGLSLTGMSNASEGSTR--LVSSQVQN----SSST-------
AqueK219_Aque -NP------------------------PVPGNGAAG--------KETGEGLSH-------
WNK_e_Smoe ------------------------------------------A-----------------
WNK_a_Smoe ------------------------------------------K-----------------
WNK_d_Smoe -----------------------------------------REES---------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------D-----------------
WNK_b-1_Smoe ------------------------------------------D-----------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel LQLRYDLLNTDSETSLALSTNSVEPQQLSTRSNTSIPNSGIQQPVQVPGQVPVSQLISVQ
Wnk1_Mmus ------------------------------------------------------------
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------------------------------------------------------------
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ------------------------------------------------------------
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -------QPFLFRH-----------ASYSSTTSDCETDGYLSSSGFL--DASDP------
Wnk3_Hsap -------VRQQLLQRKP-------QQHCSSVTGDNLSEAGAASVIHS--DT--SSQPSVA
C46C2.1_Cele -------QQPIPPP-----------LSTQTSAE---------------------------
CG7177_Dmel PQAIPSPAIPMQQK-----------PTV-HYIQPPQLASYQNSNASM--QEMTNNQVISP
Wnk1_Mmus -------QQLQYQQ-----------PSI-SVLSDGTIDSGQGSSVFT--ESRVSSQQTVS
Wnk2_Mmus -------LLPPTLP-----------ASVTSLASDSTFDSGQGSTVYS--DSQ-SSQQSMV
Wnk3_Mmus -------VRQQFLQGKP-------QQQSSSVRGDTSSEPTAGPVLHS--DT--SSHPTVA
Wnk4_Mmus -------QSFLFRH-----------ASYSSTTSDCETDGYLSSSGFL--DASDP------
Wnk1_Hsap -------QQLQYQQ-----------PSI-SVLSDGTVDSGQGSSVFT--ESRVSSQQTVS
Wnk2_Hsap -------LLPPTLP-----------TSATSLASDSTFDSGQGSTVYS--DSQ-SSQQSVM
17822_Tthe -------QSSIPKHESQNSLSSIGQNQTNSVQSSFHDQDANSKKLLT--TT--DGLTS-K
8961_Tthe -------NENIFVQVS-NTTSLVH--QSDSLETDSNYKTPQNQRNKSRMNT--FNSQSIS
WNK_Spur -------QQPISQQ-----------PH-------------------S--QSQIQQQQVPS
AqueK219_Aque -------QLL----------------------SNETTPTPQEIE-LS--ANRANFQRQLS
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe --------------------------------------------------------PS--
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap YSSNQTMGSQMV---SNI----PQAEVNVPG------QIYSSQQLVGHY----QQVS---
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel TGSQQMQQQQPV---------------------------------------------VAP
Wnk1_Mmus YGSQHEQAHSTG---------------------------------------------TAP
Wnk2_Mmus LSSLVDTAPTPA---SCV----CSPPVSEGP------GLTHSLPTLGAF----QQPATVP
Wnk3_Mmus YSSNQTTSSQVF---SSI----LQAYISVPE------QIHSSYQLLGYGIYLFSFIY---
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap YGSQHEQAHSTG---------------------------------------------TVP
Wnk2_Hsap LGSLADAAPSPA---QCV----CSPPVSEGP------VLPQSLPSLGAY----QQPTAAP
17822_Tthe NGQNDSNMEQSI---TQIPSEE--RQVKVNK------Q--QSSE----------------
8961_Tthe IQNNQSIQINTMTNNTSVVNQSTSNQVELNE------SIQSTSERF--------------
WNK_Spur HPQQTQQPSSQQ---------------------------------------------SVA
AqueK219_Aque SA----------------------------------------------------------
WNK_e_Smoe -------------------------------EAEELNATE--------------------
WNK_a_Smoe -------------------------------NLG--DATDNVSS----------------
WNK_d_Smoe -----------------------VAQVSVPEEVESPSAVDATSD----------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe -------------------------------TCE--------------------------
WNK_b-1_Smoe -------------------------------TCE--------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel TVNHQVMPQQQVNQQQQQPQMMQQIPQQVQ-VQQPQ--------------TVLPPQPHEQ
Wnk1_Mmus ----------------------GHTVSSIQAQSQPH--------------GVYPPSS-MA
Wnk2_Mmus ----------------------GLSVGPVPPPARPPLLQQHFPESSMSFTPVLPPPS-TP
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ----------------------GHIPSTVQAQSQPH--------------GVYPPSS-VA
Wnk2_Hsap ----------------------GLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPS-TP
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ------------------------TPQVQQQQ----------------------------
AqueK219_Aque --------------------------------------------------------S-DE
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ----------GLQKHS---KLTQPQILP--------------------------------
C46C2.1_Cele ---------------------------IQQ------------------------------
CG7177_Dmel QPQQQQQPLQQQLQ----QLMHTNVQAPDLTQ--QQQMAQQQAQQYFQQQQQQPQQAVNM
Wnk1_Mmus QGQNQGQPSSS-LAGV---LSSQPIQHPQQQ-GIQPTVPSQQAVQY------------SL
Wnk2_Mmus VPTGPSQPAPPVQQPL---PMAQPPTLPQVL-APQPMGTVQPVPSH------------LP
Wnk3_Mmus ----------HLQEQP---KLTQSPVLP--------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap QGQSQGQPSSSSLTGV---SSSQPIQHPQQQQGIQQTAPPQQTVQY------------SL
Wnk2_Hsap MPTGPGQPAPPGQQPP---PLAQPTPLPQVL-APQPVVPLQPVPPH------------LP
17822_Tthe ----------------------------------------SYYDQA------------IP
8961_Tthe --------------------------------------NIQKAYQN------------FK
WNK_Spur --GQPQQPQPPQQQQQPQQVQSQPVMQPPQS-VQQPLPPQVHSQTH------------SQ
AqueK219_Aque MSSEPSGPKHTTDRTG---PSAQVNN----------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele -----------------S--AQQPSVPVTMIANIPAMS----------------------
CG7177_Dmel QQAY-AMQ------------------------------QAGQQQQLSQPLQIQQQIL---
Wnk1_Mmus PQAA-SSS---EGTTAQP--VSQP------------QVSAGTQLPVSQTVATVQGE----
Wnk2_Mmus PYLA-PTSQVVAPAQLKP--LQMPQPPLQPLAQVPPQM---PQMPVVPPITPLTGLDGLP
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap SQTS-TSS---EATTAQP--VSQPQAP-----QVLPQVSAGKQLPVSQPVPTIQGE----
Wnk2_Hsap PYLA-PASQVGAPAQLKP--LQMPQAPLQPLAQVPPQM---PPIPVVPPITPLAGIDGLP
17822_Tthe NGLQ-NTKQYSKDSQT----------------------SQITQIEIKNKSQEVEDKINTP
8961_Tthe IFKQ-DQSELDTPV------------------------------DLRQISQKEQKITQQT
WNK_Spur PQLVSQSSQQPSTTAVLPQQDQAQQQPMQPSAQQP-------------PISNVQQQ----
AqueK219_Aque -----------------------------------------------------TGVGGAG
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe -----DGSH---------------------------------------------------
WNK_d_Smoe -----DETR---------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele -------PTSAQ-P-------Q--PV--L--------------S-----PT---------
CG7177_Dmel --QQQQVAVSHQ-Q-------QIMQQ--Q--------------L------AQH-QLQQLQ
Wnk1_Mmus ----PHIPVSTQ-P-------SVVPV--H--------------S------GAH-FLP---
Wnk2_Mmus Q-TLTDLPAANV-A-------PVPPPQYF--------------S------PAV-ILP---
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ----PQIPVATQ-P-------SVVPV--H--------------S------GAH-FLP---
Wnk2_Hsap P-ALPDLPTATV-P-------PVPPPQYF--------------S------PAV-ILP---
17822_Tthe S-QVQDLDSLNI-K-------ATPQITEK--------------S------NSDQVQN---
8961_Tthe P-KGSDIFSINN-SQINSSNYDIPQFKNNNGFKFIQDQQVYEES------GNFSIAS---
WNK_Spur ----PTIPAQQQ-S-------QPQQI--Q--------------QQPPQQQ--Q-LQQHQI
AqueK219_Aque GGVGSEGPSASNSP-------NVPHKITG--------------G------TAM-TTP---
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------S---AAVPVPTTM-----------------------
CG7177_Dmel QQQLQQQQLQQQQQIQQQQLQQQQL---QQQQFVQQYAQ-------AMPQQQHQQLVTGS
Wnk1_Mmus ----------------------------MGQPIPTSLLP-------QYPV---------S
Wnk2_Mmus ------------------------S---LTTPLPT--SP-------ALPM---------Q
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ----------------------------VGQPLPTPLLP-------QYPV---------S
Wnk2_Hsap ------------------------S---LAAPLPPA-SP-------ALPL---------Q
17822_Tthe ------------------------EQTT---ALEE--NK-------EQLL---------Q
8961_Tthe ------------------------ETPDLGCNL-----NNCQTNIEQQEY---------E
WNK_Spur QQQQQHQAQHQQQQQQPQSTPHSQS---QLQPQPQQ-SV-------QQPV---------Q
AqueK219_Aque ------------------------S---ENSEDSEK-ES-------VEDE---------Q
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele --IHVPKPS-------------EIPVQ---------------------------------
CG7177_Dmel Q-VMAPHQHQQPIQIPVQMQVPPTSVAPPIQ-----HTYNQQGGQVTL------------
Wnk1_Mmus ----------------------QIPISTP-------HVSTAQTGFSSVPITMAAGINQPL
Wnk2_Mmus A-VKLPHPPGTPLAVPCQTIVPNAPAAIP-------LLAVAPQGVAALSIHPAVA-QIPA
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ----------------------QIPISTP-------HVSTAQTGFSSLPITMAAGITQPL
Wnk2_Hsap A-VKLPHPPGAPLAMPCRTIVPNAPATIP-------LLAVAPPGVAALSIHSAVA-QLPG
17822_Tthe A-NQNEHL----------------------------------------------------
8961_Tthe T-SKYDPI----------------------------------------------------
WNK_Spur TQAQVQVPTQLPQSLPSQQQQQQQQAQTQQFVQQTANYTQFPQGQA-YQQSVSQG-QLPQ
AqueK219_Aque F-VSKKHSELTSAPVSSK-SLPSSSKTSP-------NLSKGKGGEEEREEHQSLS-AKGQ
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -----------------------------------ALQPPGGVPSS--------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele -NVA-----TTAAP--VAAN--NVP-PSPA------------------------------
CG7177_Dmel ---------SDAQQ-QQHPGFSAVP-QQA----APFIQQPTQQPIQ-------LS---MP
Wnk1_Mmus LTLA-----SSATA-SSIPG--GSP-VVPNQ-LPTLLQPVNQLQSQ--------------
Wnk2_Mmus QPVY-----PAAFP-QMVPG--DIP-PSPHHTVQSLRATPPQLASP--------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus -----------------------------------ALQPPGGLPSS--------------
Wnk1_Hsap LTLA-----SSATT-AAIPG--VST-VVPSQ-LPTLLQPVTQLPSQ--------------
Wnk2_Hsap QPVY-----PAAFP-QMAPT--DVP-PSPHHTVQNMRATPPQPALP-----PQPTLPPQP
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur QPIQQPLQQPIQQP-LQQPS--QVP-STPQRTASDQHAKVTRTVSGGSQHAPQPQVQPQA
AqueK219_Aque GDIV-----NRTYSEDVHQS--DLSSGSATNS----------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele --------------------------------------------PFKTEDI---------
CG7177_Dmel LE-------Q------------------------------QLQQLLHSQPAQQQQA----
Wnk1_Mmus ---------------------------------------------VHPQLLQPTTVQSIG
Wnk2_Mmus ---------------------------------------------VPPQPVQPSV-IH--
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ---------------------------------------------VHPQLLQPA-VQSMG
Wnk2_Hsap VLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQP----H--
17822_Tthe ---------------------------------------------------NQESQQQVN
8961_Tthe ---------------------------------------------------NQQNANQLE
WNK_Spur ------------------------------------------------------------
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam -----------------------------------------------HVPAN--------
Wnk4_Hsap ---------------------------------------L-AESHLC--LPSAFALSIPR
Wnk3_Hsap --LVQGQS----------------------------TVLP--------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel ----MSQQ----------------------------QQQP-LVQQQQLPLVQQQPPLVQQ
Wnk1_Mmus IPANLGQA----------------------------AEGP-LPSGDV--LYQGFPSRLPP
Wnk2_Mmus LP----EQ----------------------------AAPT-AASGTQ--VLLGH----PP
Wnk3_Mmus --VVQGQS----------------------------SVMP--------------------
Wnk4_Mmus ---------------------------------------P-AESHLC--LPSGFALSIPR
Wnk1_Hsap IPANLGQA----------------------------AEVP-LSSGDV--LYQGFPPRLPP
Wnk2_Hsap LP----EQ----------------------------AAPA-ATPGSQ--ILLGH----PA
17822_Tthe QEQNIQKDDKQN-SHEEHNDDEN--DNLKQKYYMNKN-----------------------
8961_Tthe SEQIMQNDS-QNMKSNSDGSSQTSSMSINQGIYLN-------------------------
WNK_Spur ------TQ----------------------------SQPIQQ-------QMQ----LLPP
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap S-----------------------------------------------------------
Wnk3_Hsap VHVLGP------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------QTPTLA
CG7177_Dmel QQPLVQHQQPSV------------------------------------------------
Wnk1_Mmus QYPGDSNIAPSSNVASVCIHS-TVLAPPSMP--------------TEAL-ATQGYFPTVV
Wnk2_Mmus SYTAD----VAAPVSAVSLPP-AVLSPP-LP--------------DTLLPTVPDLLPKVP
Wnk3_Mmus IYAAGV------------------------------------------------------
Wnk4_Mmus S-----------------------------------------------------------
Wnk1_Hsap QYPGDSNIAPSSNVASVCIHS-TVLSPP-MP--------------TEVL-ATPGYFPTVV
Wnk2_Hsap PYAVD----VAAQVPTVPVPPAAVLSPP-LP--------------EVLLPAAPELLPQFP
17822_Tthe -------IIFTNNNGMIT----QILPAPEKRLDEEFKMRKITEDSKEI-QEEDRLYDNNI
8961_Tthe ----------------------------------------------------------TI
WNK_Spur SQS-----AQQQQHASVTNTT-SVLKQS-IP--------------ATQQSGQPSHVPQVC
AqueK219_Aque -------------TQSINVNS-VSDATPT----------------GKDL-ARSASFYSGS
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ---------