Wnk4_Hsap MLASPATETTV--LMSQTEADLALRP-PPPLGT---AGQPR-----L------GPP----
Wnk3_Hsap MATDSGDPAST--EDSEKPDGISFEN-RVPQVAATLTVEAR-----LK------------
C46C2.1_Cele MTVICNRCRNISCRMSITNG--G-RP-PAPPSSVSSTTAST-----TG---NFGTR----
CG7177_Dmel MVLPPAPRN-----------------------LKGENTSIS-----SEEQTVQGANIQKS
Wnk1_Mmus MSDGAAEKQS------GTPGF--LTP-PAPVPKNGSSSDSS-----VGE--KLGAT----
Wnk2_Mmus MDGDGGRRD-A--PGALMEAG------------RGT-GSA--------------------
Wnk3_Mmus MATDSGEPAST--EDSEKPDGVSFEN-RAARAVAPLTVEAR-----IK------------
Wnk4_Mmus MLAPRNTETGV--PMSQTEADLALRP-SPALTS---TGPTR-----L------GPP----
Wnk1_Hsap MSGGAAEKQS------STPGSLFLSP-PAPAPKNGSSSDSS-----VGE--KLGAA----
Wnk2_Hsap MDGDGGRRD-V--PGTLMEPG------------RGA-GPA--------------------
17822_Tthe MMILKNRRIK--------------------------------------------------
8961_Tthe SDYS--------------------------------------------------------
WNK_Spur MSKSESHNSGS--SLSNGVASLEERDTDVPLKSHSSESVTK-----QGS--K-G-K----
AqueK219_Aque MTTSTQGQAVI--PEEPT-TNNHLNE-AQPISHQSSSSLLSKGLLVVGD--KIFPG----
WNK_e_Smoe MCCVMEVES---------------------------------------------------
WNK_a_Smoe MPASKP------------------------------------------------------
WNK_d_Smoe MTDKKPED-------HP-------------------------------------------
WNK_c_Smoe MTDKKPED-------HP-------------------------------------------
WNK_b-2_Smoe MRTGDGCQAEA--QLHQ-------------------------------------------
WNK_b-1_Smoe MRTGDGCQAEA--QLHQ-------------------------------------------
GK075_Glam MEIVAPLS------------------------VF------------------AGT-----
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele -RR-LVNRIKKVDE--------------------------------------LHPAQE--
CG7177_Dmel GHRSFNRSASSRQKPNPTSKLKDTLNRKPTCKQGTLSAHTSTSSTTSIQSSPIEPASSLP
Wnk1_Mmus -V-------------------------------------------------------A--
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap -A-------------------------------------------------------A--
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur -S-------------------------------------------------------G--
AqueK219_Aque -P-------------------------------------------------------A--
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam -----------QNQP---------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------NPTM---------------GSHWLS-----------------------------
CG7177_Dmel TLNTTPTPPAASKSNLFVRVLRRFSN---NTLPGKTASSPKNVDDVPKVNDNNNGDLGKQ
Wnk1_Mmus ------DSGV---------------G---RT-----------------------------
Wnk2_Mmus -------------------------G---MA-----------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------DAVT---------------G---RT-----------------------------
Wnk2_Hsap -------------------------G---MA-----------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ------DTQT---------------E---EA-----------------------------
AqueK219_Aque ------DVSS---------------L---AK-----------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------YPE---------------------------------------------------
Wnk4_Hsap ------------PRRAR-------------------------------------------
Wnk3_Hsap -----------------------------------------------EKNS---------
C46C2.1_Cele ----------EQERSRLEA---------------------------VQQDWRR-------
CG7177_Dmel QSTDVEVLCSQDNQSREQNEDEMDSKIEPADAISNQKAGLTSGKPKKDKSVKGTSQAVVS
Wnk1_Mmus ----------EEYRRRRHT---------------------------MDKDS---------
Wnk2_Mmus ----------E---------------------------------------P---------
Wnk3_Mmus -----------------------------------------------EKYS---------
Wnk4_Mmus ------------PRRVR-------------------------------------------
Wnk1_Hsap ----------EEYRRRRHT---------------------------MDKDS---------
Wnk2_Hsap ----------E---------------------------------------P---------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ----------EAADA---------------------------------------------
AqueK219_Aque ----------EDEQSGTHNL--------------------------PDVET---------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ---------R-------------FS----------GKAEPRP--RSSRLSRRSSVDLG--
Wnk3_Hsap ---------T-------------FS----------ASG-ETV--ERKRFFRKSVEMTE--
C46C2.1_Cele -------TRP-------------MK----------WTSKKRP--DDPTTSSPSTVSISNA
CG7177_Dmel DTKKMEARKSSSDTVIEPLIKQQAPLHSSKTTPTTLTA-NFV--QNIRFVRKNVEQSG--
Wnk1_Mmus ---------R-------------GA----------A-ATTTP--TEHRFFRRSVICDS--
Wnk2_Mmus ---------R-------------AR-------------AARL--GPQRFLRRSVVESD--
Wnk3_Mmus ---------T-------------FS----------ASG-ENI--ERKRFFRKSVEMTE--
Wnk4_Mmus ---------R-------------FS----------GKAEPRP--RSSRPSRRSSVDLG--
Wnk1_Hsap ---------R-------------GA----------A-ATTTT--TEHRFFRRSVICDS--
Wnk2_Hsap ---------R-------------AK-------------AARP--GPQRFLRRSVVESD--
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ---------------------------------------SHSGVNGESSMGNSVV-ISNR
AqueK219_Aque ---------M-------------GS-------------SS----------RPNGVIIENG
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe -------------------------------------QE---------------------
WNK_c_Smoe -------------------------------------QE---------------------
WNK_b-2_Smoe -------------------------------------CENR---SRSRFL----------
WNK_b-1_Smoe -------------------------------------CENR---SRSRFL----------
GK075_Glam -----------------------VE-----------------------------------
Wnk4_Hsap ---------LLS-SWSLPASP-A-----------------------PDPPDPP-------
Wnk3_Hsap ---------DDK-VA----------------------------------ESSPKDERIKA
C46C2.1_Cele LENSTPSLNNVS-SITNSSSP-FSL----SSAATSTASAIIPFTSNVATNHPHLNHH-VS
CG7177_Dmel ---------RNTNPLQFVELE-TEFPRDY------------------------DDNI-EM
Wnk1_Mmus ---------NAT-ALELPGLP-LSIPQPSVPA-------VVP---QSAPPEPHREET-LT
Wnk2_Mmus ---------QEE----PPGLE---------AA-------ETP---SAQPPQPLQRRV-LL
Wnk3_Mmus ---------DDK-VA----------------------------------ESSRRDER-KA
Wnk4_Mmus ---------LLS-SWSQPASL-L-----------------------PEPPDPP-------
Wnk1_Hsap ---------NAT-ALELPGLP-LSLPQPSIPA-------AVP---QSAPPEPHREET-VT
Wnk2_Hsap ---------QEE----PPGLE---------AA-------EAP---GPQPPQPLQRRV-LL
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur R------------------SPNFSD-----------------TDVNVESFHN--------
AqueK219_Aque GETNVHFVS---------------------------------SKEEVLPTEPEKQK----
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -------------------------------------DSAGPGPA--RSPPPS-------
Wnk3_Hsap AMNI----PR-------------VDKLPSN-VLRGGQ-----------------------
C46C2.1_Cele RIPQ----AIVTGGTNGSLPPLLISPTSAAAATPLISGKAGPMSP--STGSPINVAATVL
CG7177_Dmel LSREAEHLEE-------------QFRTPTRS-----------------------------
Wnk1_Mmus ATVA----SQ-------------VSQQPSAAASPGEQAVVGSATT--TVPSST-------
Wnk2_Mmus LCKTRRLIAE-------------RARGRPAAPAPAAP-AAPPGSP--SVPSDP-------
Wnk3_Mmus ATNI----SR-------------VDKVPTN-VLRGGQ-----------------------
Wnk4_Mmus -------------------------------------DSAG--PT--RSPPSS-------
Wnk1_Hsap ATAT----SQ-------------VAQQPPAAAAPGEQAVAGPAPS--TVPSST-------
Wnk2_Hsap LCKTRRLIAE-------------RARGRPAAPAPAAL-VAQPGAP--GAPADA-------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur --------DK-------------VTENSES-AADTKHTVISDESS--TTGYSS--RLDSI
AqueK219_Aque -------------------------------------QDGGPVGGGVTPPI--QDSQDGV
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ----------------------------------------------------------SK
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele QNAVSSPQHS-----------------------------------------IFDRSRLNK
CG7177_Dmel ---------NATDATSHHVAGIIDNIITEASRSLTIEKTEDDVPLKSSTKHS--------
Wnk1_Mmus ----------------------------------------------------------SK
Wnk2_Mmus ----------------------------------------------------------GP
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ----------------------------------------------------------SK
Wnk1_Hsap ----------------------------------------------------------SK
Wnk2_Hsap ----------------------------------------------------------GP
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur G-------D---------------------------------------------KELLKE
AqueK219_Aque K-------KK-----------------------------------------VLETLEVEE
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap EPPE------GTW-TEGAPVKAA------------------------------------E
Wnk3_Hsap ------------------EVKY--------------------------------------
C46C2.1_Cele IPPN------TSLASSSSPSDAA---NNDKPIQQRHS-----ILSNVRTLTQAMVNDGPR
CG7177_Dmel --S-------GVK---------------------RVGFQVEDK-----------------
Wnk1_Mmus DRPV------S----QPSLVGS-------------------------------------K
Wnk2_Mmus ERAG-------TQEPSPDPTTAS---AAAAQV----------------------PDGGPR
Wnk3_Mmus ------------------EVKY--------------------------------------
Wnk4_Mmus EPPE------GTW-MGAAPVKAV-------------------------------------
Wnk1_Hsap DRPV------S----QPSLVGS-------------------------------------K
Wnk2_Hsap EPVG-------TQEPGPDPIAAA---VETAPA----------------------PDGGPR
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur KVPDTSVHLANSH-PNGTALKSARKDSNMKPERGRIA-------------------SGNG
AqueK219_Aque HIV-------NTS-PTGRFVKYE---Q---EI-GRGSFKTVYKG----------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------DSARPELPDSAVG------PGSREPLRVP---EAVALER----RREQ-------
Wnk3_Hsap -----------------EQ--------CSK--STS---EISKDCFK--EKNEK-------
C46C2.1_Cele -----------TLT--GDD------M--DK--MVS----EEERARK--EQEKREEEEKA-
CG7177_Dmel --------------------------DDTE--VQSEKQAKS-----FDDITKKAESSEAS
Wnk1_Mmus ------EEPPPSRS--GSG------SGGA----SA---KEAQEDR----SQQQ-------
Wnk2_Mmus ------QEEAPAPTQEDA--------GTTE--AKP----EPGRARK--DEPEE-------
Wnk3_Mmus -----------------EQ--------CSK--ATS---ESSKDCFK--EKTEK-------
Wnk4_Mmus ------DSACPELTGSSGG------PGSREPPRVP---DAAARER----RREQ-------
Wnk1_Hsap ------EEPPPARS--GSG------GG------SA---KEPQEER----SQQQ-------
Wnk2_Hsap ------EEAAATVRKEDE--------GAAE--AKP----EPGRTRR--DEPEE-------
17822_Tthe -------------------------------------------------SLKKV------
8961_Tthe -------------------------------------------------DRDE-------
WNK_Spur KKQKSVVIMAPVKDITENGHIEVHKEEKVEPLQIH---EMHDSERRLLIETEE-------
AqueK219_Aque ---------LDTE----TG------VAVAW--CEL---LDSQDGI----KKKV-------
WNK_e_Smoe ---------------------------------------------------GA-------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe -------------------------------------------ARN--ESKSG-------
WNK_c_Smoe -------------------------------------------ARN--ESKSG-------
WNK_b-2_Smoe ------------------------------------------ASRM---SSQL-------
WNK_b-1_Smoe ------------------------------------------ASRM---SSQL-------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -----------------------------------EEKEDMETQAVA-------------
Wnk3_Hsap -----------------------------------EMEEEAEMKAVA-------------
C46C2.1_Cele -----------------------------ARRIDVEDDFDAQEKPID-------------
CG7177_Dmel AEEAAVTGSSTDASASPLPSTSLVSTTSSATS-ITKSKSDEDDDPVA-------------
Wnk1_Mmus -----------------------------------DDIEELETKAVG-------------
Wnk2_Mmus -----------------------------------EEDDEDDLKAVA-------------
Wnk3_Mmus -----------------------------------EMEEEAEMKAVA-------------
Wnk4_Mmus -----------------------------------EEKEDTETQAVA-------------
Wnk1_Hsap -----------------------------------DDIEELETKAVG-------------
Wnk2_Hsap -----------------------------------EEDDEDDLKAVA-------------
17822_Tthe -----------------------------------LKEDLFEQELVQYYYWKIFIFKAIV
8961_Tthe -----------------------------------NEDNDYKDRIAE-------------
WNK_Spur -----------------------------------AEPEAVEEKAIA-------------
AqueK219_Aque -----------------------------------LETLEVEEHIVN-------------
WNK_e_Smoe -----------------------------------NAADADDSEFVE-------------
WNK_a_Smoe -----------------------------------GAESDTGSEFVE-------------
WNK_d_Smoe -----------------------------------KEGEDEEAEFVE-------------
WNK_c_Smoe -----------------------------------KEGEDEEAEFVE-------------
WNK_b-2_Smoe -----------------------------------DLGSEDEAEFVE-------------
WNK_b-1_Smoe -----------------------------------DLGSEDEAEFVE-------------
GK075_Glam -----------------------------SSP-LRNEGVYYNPFSDT-------------
Wnk4_Hsap -----------------TSPDGRYLKFDI-EIGRGSFKTVYRGLDTDTTVEVAWCELQTR
Wnk3_Hsap -----------------TSPSGRFLKFDI-ELGRGAFKTVYKGLDTETWVEVAWCELQDR
C46C2.1_Cele -----------------KSKNGRFLKFDE-ELGRGSFKTVFRGLDTETGVAVAWCELQES
CG7177_Dmel -----------------MSPCGRFFKYDK-EVGRGSFKTVYRGLDTLTGVPVAWCELLDK
Wnk1_Mmus -----------------MSNDGRFLKFDI-EIGRGSFKTVYKGLDTETTVEVAWCELQDR
Wnk2_Mmus -----------------TSLDGRFLKFDI-ELGRGSFKTVYKGLDTETWVEVAWCELQDR
Wnk3_Mmus -----------------TSPSGRFLKFDI-ELGRGAFKTVYKGLDTETWVEVAWCELQDR
Wnk4_Mmus -----------------TSPDGRYLKFDI-EIGRGSFKTVYRGLDTDTTVEVAWCELQTR
Wnk1_Hsap -----------------MSNDGRFLKFDI-EIGRGSFKTVYKGLDTETTVEVAWCELQDR
Wnk2_Hsap -----------------TSLDGRFLKFDI-ELGRGSFKTVYKGLDTETWVEVAWCELQDR
17822_Tthe SCHYSFISTKFHQNTNQIFLQIIKIKFNE-ELGFGAYKTVYKGYDNDSGCEIAWNVIKLQ
8961_Tthe -----------------TSPKGRFIRFNE-ELGFGAYKTVYRAYDNDSGCEVAWNVIKLQ
WNK_Spur -----------------KSADGRFMKYDV-AVGQGSFKTVFRGLDTETGVAVAWCELQER
AqueK219_Aque -----------------TSPTGRFVKYEQ-EIGRGSFKTVYKGLDTETGVAVAWCELLEH
WNK_e_Smoe -----------------VDPTGRYGRYNE-VLGRGAFKTVYKAFDEVDGIEVAWNQVNVQ
WNK_a_Smoe -----------------IDPTGRYGRYSE-VLGKGAFKAVYRAFDEVDGLEVAWNQVNVQ
WNK_d_Smoe -----------------RDPTGRYGRYNE-ILGKGAFKTVYRAFDEVDGIEVAWNQVKVE
WNK_c_Smoe -----------------RDPTGRYGRYNE-ILGKGAFKTVYRAFDEVDGIEVAWNQVKVE
WNK_b-2_Smoe -----------------VDPTGRYGRYKE-LLGKGAFKTVYKAFDEIDGIEVAWNQVKLH
WNK_b-1_Smoe -----------------VDPTGRYGRYKE-LLGKGAFKTVYKAFDEIDGIEVAWNQVKLH
GK075_Glam -----------------LGPSDRYLKYSGDVLGKGAFKTVYRAFDLIAGREVAWNEVVLD
::. :* *::*:*::. * :** :
Wnk4_Hsap KLS--RAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKT
Wnk3_Hsap KLT--KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESIL--KGKKCIVLVTELMTSGTLKT
C46C2.1_Cele KLN--KTERQRFREEAEMLKDLQHPNIVRFYDYWESADLCGKRKYIVLVTELMTSGTLKM
CG7177_Dmel QVK--KSERTRFREEADMLKKLQHPNIVRFYTYWEFPI--GRKKNIVLVTELMLSGTLKS
Wnk1_Mmus KLT--KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKT
Wnk2_Mmus KLT--KLERQRFKEEAEMLKGLQHPNIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKT
Wnk3_Mmus KLT--KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTL--KGKKCIVLVTELMTSGTLKT
Wnk4_Mmus KLS--RAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKT
Wnk1_Hsap KLT--KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKT
Wnk2_Hsap KLT--KLERQRFKEEAEMLKGLQHPNIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKT
17822_Tthe RLP--Q--------------------------------------------QCLSGGSLK-
8961_Tthe RLP--LNERKRISEEIQLLKNLHHPNIINFINAWINKS----KNEVIFITECVSGGSLKK
WNK_Spur KLS--RSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSP-RGKKHIVLVTELMTSGTLKT
AqueK219_Aque KFN--KEEQSRFKEEVAILKTLNHPYILRLFDSWEFVRQSDKKRVLVLITELMTSGTLKS
WNK_e_Smoe DVLGRPEDLERLYSEVHLLRGLKHKNVIKFFTSWVDPR----TKNVNFITEIFTSGTLRQ
WNK_a_Smoe DLLRSPDDLERLYSEVHLLKTLKHKNIIKFYTSWVDSK----RRNVNFITEIFTSGTLRQ
WNK_d_Smoe DVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQ
WNK_c_Smoe DVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQ
WNK_b-2_Smoe DVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDTK----NNNVNFITEIFTSGNLRQ
WNK_b-1_Smoe DVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDTT----SNNVNFITEIFTSGNLRQ
GK075_Glam TLE--PMASSKLFQEIKALKDVDHENIIKLYDHWFE-----GSNLLIFTTELMPSGCLKK
. : . .* *:
Wnk4_Hsap YLRRFR-EMKPRV-LQRWSRQILRGLHFLHSRVP-PILHRDLKCDNVFITGPTGSVKIGD
Wnk3_Hsap YLKRFK-VMKPKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
C46C2.1_Cele YLKRFK-RINIKVVLKSWCRQILKGLSFLHTRNP-PVIHRDLKCDNIFITGTTGSVKIGD
CG7177_Dmel YLKRFK-KIHPKV-LKSWCRQILKGLNFLHTRQF-PIIHRDLKCDNIFITGTTGSVKIGD
Wnk1_Mmus YLKRFK-VMKIKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk2_Mmus YLKRFK-VMKPKV-LRSWCRQILKGLLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk3_Mmus YLKRFK-VMKPKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk4_Mmus YLRRFR-EMKPRV-LQRWSRQILRGLHFLHSRVP-PILHRDLKCDNVFITGPSGSVKIGD
Wnk1_Hsap YLKRFK-VMKIKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk2_Hsap YLKRFK-VMKPKV-LRSWCRQILKGLLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
17822_Tthe ---KIK-KPRLKI-IKQWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGD
8961_Tthe HLKKIK-KPRLKI-IKNWCRQILKGLVYLHEQKPYPIIHRDIKCENVFISTTNNEIRIGD
WNK_Spur YLKRFK-GVKNRV-LRSWCRQILKGLHFLHTRQP-PIIHRDLKCDNIFITGTSGAVKIGD
AqueK219_Aque YMRRFK-SIKPRV-IRSWGRQILRGLSFLHTRTP-PIIHRDLKCDNVFINGTTGLVKIGD
WNK_e_Smoe YRKKHK-NVDMKA-VKNWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNQGEVKIGD
WNK_a_Smoe YRKKHK-NVDMKA-VKNWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNYGEVKIGD
WNK_d_Smoe YRKKHK-HVDMRA-VKNWAKQILRGLLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGD
WNK_c_Smoe YRKKHK-HVDMRA-VKNWAKQILRGLLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGD
WNK_b-2_Smoe YRRKHK-HVDLKA-VKHWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGD
WNK_b-1_Smoe YRRKHK-HVDLKA-VKHWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGD
GK075_Glam YLKKNPTALTTPV-LKSWALQILEALNYMHTCQP-KIIHRDIKAQNIFINGATGVVKVGD
: :: * *** .* ::* ::***:*.:*:*:. . :::**
Wnk4_Hsap LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSEC
Wnk3_Hsap LGLA-TL-MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
C46C2.1_Cele LGLA-TL-KNKSFAKSVIGTPEFMAPEMYE-EMYDESVDVYAFGMCLLEMVTGEYPYSEC
CG7177_Dmel LGLA-TL-KNRSHAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMAISEYPYSEC
Wnk1_Mmus LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk2_Mmus LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk3_Mmus LGLA-TL-MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk4_Mmus LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSEC
Wnk1_Hsap LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk2_Hsap LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
17822_Tthe LGLA-LT-LKSDFTTSVLGTPEFMAPEIYE-EKYGTAVDIYAFGMCLLEMATLQIPYREC
8961_Tthe LGLA-VSLKNSSHTKSVIGTPEFMAPEIYE-EKYGTPVDIYSFGMCVLEMATLSTPYKEC
WNK_Spur LGLA-TL-KKSSFAKSVIGTPEFMAPEMYE-EHYDEAVDVYAFGMCLLEMATSEYPYAEC
AqueK219_Aque LGLA-TL-KRS-DVKTVIGTPEFMAPEMYD-EVYDESVDVYAFGMCLLEMCTLEYPYQEC
WNK_e_Smoe LGLA-TILRQAHAAHSVIGTPEFMAPELYE-EDYNELVDIYAFGMCVLELVTFDYPYSEC
WNK_a_Smoe LGLA-TILRQAHAAHSVIGTPEFMAPELYE-EEYDELVDIYSFGMCVLEMVTFEYPYSEC
WNK_d_Smoe LGLA-AILRQAHAAHSVIGTPEFMAPELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSEC
WNK_c_Smoe LGLA-AILRQAHAAHSVIGTPEFMAPELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSEC
WNK_b-2_Smoe LGLA-GILRQAHGAHSVIGTPEFMAPELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSEC
WNK_b-1_Smoe LGLA-GILRQAHGAHSVIGTPEFMAPELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSEC
GK075_Glam LGLCASL-GLQSTAVSCIGTPEFMAPETYSNAHYDEKVDIYAFGMLLLELITRDTPYLEC
***. . : :********* *. *. **:*:*** :**: . ** **
Wnk4_Hsap QNAAQIYRKVTSGRKPNSFHKV--KIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREER
Wnk3_Hsap QNAAQIYRKVTSGIKPASFNKV--TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT
C46C2.1_Cele MNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFFTPED
CG7177_Dmel KGPAQIYKKVISGIKPAALAKV--EDPNVRDIIERCIELKKEDRPSCNELLESEFFDEDI
Wnk1_Mmus QNAAQIYRRVTSGVKPASFDKV--AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET
Wnk2_Mmus QNAAQIYRKVTCGIKPASFEKV--HDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDT
Wnk3_Mmus QNAAQIYRKVTSGIKPASFNKV--TDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDT
Wnk4_Mmus QNAAQIYRKVTSGTKPNSFYKV--KMPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREER
Wnk1_Hsap QNAAQIYRRVTSGVKPASFDKV--AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET
Wnk2_Hsap QNAAQIYRKVTCGIKPASFEKV--HDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDT
17822_Tthe TSAAQVYKKVSQGLLPNSLQLI--QNDSLKQFILKCIQR-SENRPSAAQLLQDDFFKESE
8961_Tthe TSAAQVYKKVSQGILPYQIDLI--QNEGLKNLILKCLSH-YKDRPSAEELLNDKFLDMSE
WNK_Spur SNAAQIYRRVTTGVKPQSFEKV--NDNKIKEIIDGCTKTNNTERYLIQELLKHTFFED-T
AqueK219_Aque SNPAQIYKKVTSGVMPNSLNKV--NDPMLKEIIVACTKLSKSARYTVEMLLNHEFFAEGD
WNK_e_Smoe TNAAQIYKKVSSGIKPAALDKV--KDPEVRSFIQKCLAT-ASKRLPARELLKDPFLQCES
WNK_a_Smoe TNAAQIYKRVTSGKKPAAFEKV--KDPEVRKFIEKCLAA-VSRRLPARELLMDPFLRCDG
WNK_d_Smoe TNAAQIYKKVTSGKKPAALDRV--KDLEVRAFIEKCLAT-VSKRLPARELLMDPFLQSED
WNK_c_Smoe TNAAQIYKKVTSGKKPAALDRV--KDLEVRAFIEKCLAT-VSKRLPARELLMDPFLQSED
WNK_b-2_Smoe MNAAQIYKKVTSGKKPAALNKV--QDPQMRAFVEQCLAK-ACRRLPARELLMDPFLQCHT
WNK_b-1_Smoe MNAAQIYKKVTSGKKPAALNKV--QDPQMRAFVEQCLAK-ACRRLPARELLMDPFLQCHT
GK075_Glam ANIVDVLKKVEGNIPPNGLNKV--VHKEMKDLILLCINKDPSARPSARELLSKPFLSNMS
. . : ::* . * : : :: :: * * ** *:
Wnk4_Hsap --GVH---VELAEEDDG------------E------------------------------
Wnk3_Hsap --GLR---VELAEEDDC------------S------------------------------
C46C2.1_Cele LIGIR---VEIKNRDAD------------LNDL---------------------------
CG7177_Dmel --GIR---VEPTASEQF-----------LSDPS---------------------------
Wnk1_Mmus --GVR---VELAEEDDG------------E------------------------------
Wnk2_Mmus --GVR---VELAEEDHG------------R------------------------------
Wnk3_Mmus --GLR---VELAEEDDC------------S------------------------------
Wnk4_Mmus --GVH---VELAEEDDG------------E------------------------------
Wnk1_Hsap --GVR---VELAEEDDG------------E------------------------------
Wnk2_Hsap --GVR---VELAEEDHG------------R------------------------------
17822_Tthe I---DNQPIQLASDR---------------IPQ---------------------------
8961_Tthe Q-DEDNYPVQLLDAS---------------NAS---------------------------
WNK_Spur --AFR---VDIVHDDN--------------------------------------------
AqueK219_Aque ---VK---VEVMTEPTP------------AD-----------------------------
WNK_e_Smoe D--RDGVADSLPSLNKD---------RVN---DMEEL---------PSRNPYSEFKDDTQ
WNK_a_Smoe E---RESLE--------CIPVIRKQSRVD---DMEELRSSAVTNHE----SDQGDSDQQR
WNK_d_Smoe R--EPLDPEQ-SQTDS-------------DQGGLGSYQKGV------------SFREEGK
WNK_c_Smoe R--EPLELVP-PISRS--------TSRADDMEGLST------------------------
WNK_b-2_Smoe A--ERGVVHE-PHNSMDELEVILEEN---GDDSLSTIHAGAMAYDLAPRGAHHNHHELTR
WNK_b-1_Smoe A--ERGVVHE-PHDSMDELEVILEEN---GDDSLSTIHAGAMAYDLAPRGAHHNHHELTR
GK075_Glam --DTG-K-LTTDAKDHG-----------P-SAQ---------------------------
Wnk4_Hsap -------------K----------PGLKLWLRMEDA-------------R-RG-GRPRDN
Wnk3_Hsap -------------N----------SSLALRLWVEDP-------------KKLK-GKHKDN
C46C2.1_Cele -------------N----------VEIQMQLRVYDE-------------KKRKQYRFKEN
CG7177_Dmel -------------I----------SIIEFRLRFMDP-------------KKRS-SRHKEN
Wnk1_Mmus -------------K----------IAIKLWLRIEDI-------------KKLK-GKYKDN
Wnk2_Mmus -------------K----------STIALRLWVEDP-------------KKLK-GKPKDN
Wnk3_Mmus -------------N----------SSLALRLWVEDP-------------KKLK-GKHKDN
Wnk4_Mmus -------------K----------PGLKLWLRMEDA-------------R-RG-GRPRDN
Wnk1_Hsap -------------K----------IAIKLWLRIEDI-------------KKLK-GKYKDN
Wnk2_Hsap -------------K----------STIALRLWVEDP-------------KKLK-GKPKDN
17822_Tthe ------SLGNSNDS---------------------P--------------Q-------TN
8961_Tthe ------------------------------------------------------------
WNK_Spur -------------K----------DQIQLQLRVEDP-------------KKRR-ERHRDN
AqueK219_Aque -------------------------SVMVRLVVPRT-------------SK-E-NKKNEQ
WNK_e_Smoe KSKDFKVKGKLRQ-----------DNIFLRLRISEQ--------------G-------HV
WNK_a_Smoe KSIDFKVKGRRRED----------DTIFLRLRIADP-------------EG-------HI
WNK_d_Smoe RSRDFRVKGKKKDD----------DTIFLRVRIADL-------------EG-------HV
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe RSRDFRVRVRRRND----------DTIFLKLRIADQ-------------EG-------CI
WNK_b-1_Smoe RSRDFRVRVRRRND----------DTIFLKLRIADQ-------------EG-------CI
GK075_Glam -------------VSLGTHEQTMQSTGHTAVNAAQTALKLPQQSSLPISSPRG-PQQSH-
Wnk4_Hsap QAIEFLFQLGRDAAEEVAQEMVALGL-------------------------VCE--ADYQ
Wnk3_Hsap EAIEFSFNLETDTPEEVAYEMVKSGF-------------------------FHE--SDSK
C46C2.1_Cele EGLQFAFDIENDSPDEVVQQMIEQQH-------------------------IPD--EDTR
CG7177_Dmel EAIQFEYNIRHDEYEQIAQEMMKENI-------------------------ISE--DDSR
Wnk1_Mmus EAIEFSFDLERDVPEDVAQEMVESGY-------------------------VCE--GDHK
Wnk2_Mmus GAIEFTFDLEKETPDEVAQEMIDSGF-------------------------FHE--SDVK
Wnk3_Mmus EAIEFSFNLEADTPEEVAYEMVKSGF-------------------------FHE--SDSK
Wnk4_Mmus QAIEFLFQLGRDAAEEVAQEMVALGL-------------------------VCE--ADYQ
Wnk1_Hsap EAIEFSFDLERDVPEDVAQEMVESGY-------------------------VCE--GDHK
Wnk2_Hsap GAIEFTFDLEKETPDEVAQEMIESGF-------------------------FHE--SDVK
17822_Tthe H-QQQSFQQNQDQHSQVQSSNFKKTS-------------------------DFE--SPIH
8961_Tthe --TPMNYTLSNSCPLESAQVFQLKGQKNTEASPCTDQNQNNEIQSQEIHSDNLK--DNMF
WNK_Spur EALQFEIDLNKDEPDQVAKEMVRIGF-------------------------VSE--EDSK
AqueK219_Aque ESIEFAYNLQTDIPEDIVNDMVKSGI-------------------------LRE--EDKK
WNK_e_Smoe RNIHFAFDLEADTAFSVASEMVTELD-------------------------LSD--QDVA
WNK_a_Smoe RNIHFPFDVEGDTALSVASEMVAELD-------------------------LSD--QDVT
WNK_d_Smoe RNIHFPFSIEGDTAMSVASEMVAELD-------------------------LSD--QDVT
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe RNIHFPFDVEADTALCVASEMVAELD-------------------------LSD--QDVT
WNK_b-1_Smoe RNIHFPFDVEADTALCVASEMVAELD-------------------------LSD--QDVT
GK075_Glam ----IPQSL--SKPVCPASMGVSVVN-------------------------VAVPTTAVT
Wnk4_Hsap PVARAVRE----RVAAIQRK----RE---KLR-KAR----ELEALPP------E------
Wnk3_Hsap AVAKSIRD----RVTPIKKT----RE---KKP-AG-----CLEERRD------SQCKSM-
C46C2.1_Cele MITKLIKD----KVDAFRRD----RD---HRL-LEIKRAKEEEERIR-------EEAEIK
CG7177_Dmel AVARLLKV----QVVSLLKE----RA---QRQ-TQIKL---QNEKSR------LEKLALQ
Wnk1_Mmus TMAKAIKD----RVSLIKRK----RE---QRQ-LVR----EEQEKRK------QEESSFK
Wnk2_Mmus IVAKSIRD----RVALIQWR----RE---RIW-PAL----QSQEPKD------SGSPDKA
Wnk3_Mmus AVAKSIRD----RVTLIKKI----RE---KKP-AG-----CLEERRD------SQCKYV-
Wnk4_Mmus PVARAVRE----RVAAIQRK----RE---KLR-KAR----ELEVLPP------D------
Wnk1_Hsap TMAKAIKD----RVSLIKRK----RE---QRQ-LVR----EEQEKKK------QEESSLK
Wnk2_Hsap IVAKSIRD----RVALIQWR----RE---RIW-PAL----QPKEQQD------VGSPDKA
17822_Tthe QVSQKQDNNSSSSASKSSHS----KQHRGSNQAS----------------P-AQSQNS-S
8961_Tthe -IPRKQSNFSDKKTTSLSHK----KK---KNQLTI-----DVTEYDFDEVN-KQQQLALQ
WNK_Spur AVTKVIRD----RIGTVWKN----RE---KRE-KER----QEKGKLE------EDKDSKA
AqueK219_Aque NAIRSVRE----LTDPLTDPAKQKRQ---QKP-A-A----TAGATAP------HG-----
WNK_e_Smoe TIAEMIDA----EILSLVPD----WK---P---GG-----AFDADDEKG---VEDTGPV-
WNK_a_Smoe TIAEMIDA----EILNLVPD----WK---P---GA-----AFDESGGDGENNYIDGDDM-
WNK_d_Smoe TIAEMIDA----AIVALVPD----WR---P---GA-----SFEDNGVTE---VDDQAQA-
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe TIADMIDA----EIVLLVPH----WR---P---GA-----SFEEHREDTI--LHDTDDI-
WNK_b-1_Smoe TIADMIDA----EIVLLVPH----WR---P---GA-----SFEEHREDTT--LHDTDDI-
GK075_Glam ---------------NSLSH----VL---ASE--TVST---DQSGSI------L------
Wnk4_Hsap ---PGPPPA---------------TVPMAPG--P---PSVFPPEPEEPEADQH-------
Wnk3_Hsap -GNVFPQPQ-------------NTTLPLA----P---AQQTGAECEETEVDQH-------
C46C2.1_Cele E--ELRLRAEAKEKEKERLEKERLEKKAAAAAAANPNPTPIPPTPATPHSSAQ-------
CG7177_Dmel K--QRE------------------SLP----TN----VDEDEEEEEESEDEEDGVKWNQR
Wnk1_Mmus Q--QNEQQASVSQAGIQQLSAASTGIPTAPATSA---SVSTQVEPEEPEADQH-------
Wnk2_Mmus RGLPAPLQV-------------QVTYH----AQS---GQPGQPEPEEPEADQH-------
Wnk3_Mmus -RNVLPQQQ-------------TATLQPT----P---GPHTAAEYEETEVDQH-------
Wnk4_Mmus ---SGPPPA---------------TVSLAPG--P---PSAFPPEPEEPEADQH-------
Wnk1_Hsap Q--QVEQS-SASQTGIKQLPSASTGIPTASTTSA---SVSTQVEPEEPEADQH-------
Wnk2_Hsap RGPPVPLQV-------------QVTYH----AQA---GQPGPPEPEEPEADQH-------
17822_Tthe Q---------------------------------------SSEKPAQQNLTQN-------
8961_Tthe Q---------------------------------------QQEKQIQQDLVQV-------
WNK_Spur -----DAGTSTTDSGMGFSGLSLTGMSNASEGSTR--LVSSQVQN----SSST-------
AqueK219_Aque -NP------------------------PVPGNGAAG--------KETGEGLSH-------
WNK_e_Smoe ------------------------------------------A-----------------
WNK_a_Smoe ------------------------------------------K-----------------
WNK_d_Smoe -----------------------------------------REES---------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------D-----------------
WNK_b-1_Smoe ------------------------------------------D-----------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel LQLRYDLLNTDSETSLALSTNSVEPQQLSTRSNTSIPNSGIQQPVQVPGQVPVSQLISVQ
Wnk1_Mmus ------------------------------------------------------------
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------------------------------------------------------------
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ------------------------------------------------------------
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -------QPFLFRH-----------ASYSSTTSDCETDGYLSSSGFL--DASDP------
Wnk3_Hsap -------VRQQLLQRKP-------QQHCSSVTGDNLSEAGAASVIHS--DT--SSQPSVA
C46C2.1_Cele -------QQPIPPP-----------LSTQTSAE---------------------------
CG7177_Dmel PQAIPSPAIPMQQK-----------PTV-HYIQPPQLASYQNSNASM--QEMTNNQVISP
Wnk1_Mmus -------QQLQYQQ-----------PSI-SVLSDGTIDSGQGSSVFT--ESRVSSQQTVS
Wnk2_Mmus -------LLPPTLP-----------ASVTSLASDSTFDSGQGSTVYS--DSQ-SSQQSMV
Wnk3_Mmus -------VRQQFLQGKP-------QQQSSSVRGDTSSEPTAGPVLHS--DT--SSHPTVA
Wnk4_Mmus -------QSFLFRH-----------ASYSSTTSDCETDGYLSSSGFL--DASDP------
Wnk1_Hsap -------QQLQYQQ-----------PSI-SVLSDGTVDSGQGSSVFT--ESRVSSQQTVS
Wnk2_Hsap -------LLPPTLP-----------TSATSLASDSTFDSGQGSTVYS--DSQ-SSQQSVM
17822_Tthe -------QSSIPKHESQNSLSSIGQNQTNSVQSSFHDQDANSKKLLT--TT--DGLTS-K
8961_Tthe -------NENIFVQVS-NTTSLVH--QSDSLETDSNYKTPQNQRNKSRMNT--FNSQSIS
WNK_Spur -------QQPISQQ-----------PH-------------------S--QSQIQQQQVPS
AqueK219_Aque -------QLL----------------------SNETTPTPQEIE-LS--ANRANFQRQLS
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe --------------------------------------------------------PS--
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap YSSNQTMGSQMV---SNI----PQAEVNVPG------QIYSSQQLVGHY----QQVS---
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel TGSQQMQQQQPV---------------------------------------------VAP
Wnk1_Mmus YGSQHEQAHSTG---------------------------------------------TAP
Wnk2_Mmus LSSLVDTAPTPA---SCV----CSPPVSEGP------GLTHSLPTLGAF----QQPATVP
Wnk3_Mmus YSSNQTTSSQVF---SSI----LQAYISVPE------QIHSSYQLLGYGIYLFSFIY---
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap YGSQHEQAHSTG---------------------------------------------TVP
Wnk2_Hsap LGSLADAAPSPA---QCV----CSPPVSEGP------VLPQSLPSLGAY----QQPTAAP
17822_Tthe NGQNDSNMEQSI---TQIPSEE--RQVKVNK------Q--QSSE----------------
8961_Tthe IQNNQSIQINTMTNNTSVVNQSTSNQVELNE------SIQSTSERF--------------
WNK_Spur HPQQTQQPSSQQ---------------------------------------------SVA
AqueK219_Aque SA----------------------------------------------------------
WNK_e_Smoe -------------------------------EAEELNATE--------------------
WNK_a_Smoe -------------------------------NLG--DATDNVSS----------------
WNK_d_Smoe -----------------------VAQVSVPEEVESPSAVDATSD----------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe -------------------------------TCE--------------------------
WNK_b-1_Smoe -------------------------------TCE--------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel TVNHQVMPQQQVNQQQQQPQMMQQIPQQVQ-VQQPQ--------------TVLPPQPHEQ
Wnk1_Mmus ----------------------GHTVSSIQAQSQPH--------------GVYPPSS-MA
Wnk2_Mmus ----------------------GLSVGPVPPPARPPLLQQHFPESSMSFTPVLPPPS-TP
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ----------------------GHIPSTVQAQSQPH--------------GVYPPSS-VA
Wnk2_Hsap ----------------------GLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPS-TP
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ------------------------TPQVQQQQ----------------------------
AqueK219_Aque --------------------------------------------------------S-DE
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ----------GLQKHS---KLTQPQILP--------------------------------
C46C2.1_Cele ---------------------------IQQ------------------------------
CG7177_Dmel QPQQQQQPLQQQLQ----QLMHTNVQAPDLTQ--QQQMAQQQAQQYFQQQQQQPQQAVNM
Wnk1_Mmus QGQNQGQPSSS-LAGV---LSSQPIQHPQQQ-GIQPTVPSQQAVQY------------SL
Wnk2_Mmus VPTGPSQPAPPVQQPL---PMAQPPTLPQVL-APQPMGTVQPVPSH------------LP
Wnk3_Mmus ----------HLQEQP---KLTQSPVLP--------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap QGQSQGQPSSSSLTGV---SSSQPIQHPQQQQGIQQTAPPQQTVQY------------SL
Wnk2_Hsap MPTGPGQPAPPGQQPP---PLAQPTPLPQVL-APQPVVPLQPVPPH------------LP
17822_Tthe ----------------------------------------SYYDQA------------IP
8961_Tthe --------------------------------------NIQKAYQN------------FK
WNK_Spur --GQPQQPQPPQQQQQPQQVQSQPVMQPPQS-VQQPLPPQVHSQTH------------SQ
AqueK219_Aque MSSEPSGPKHTTDRTG---PSAQVNN----------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele -----------------S--AQQPSVPVTMIANIPAMS----------------------
CG7177_Dmel QQAY-AMQ------------------------------QAGQQQQLSQPLQIQQQIL---
Wnk1_Mmus PQAA-SSS---EGTTAQP--VSQP------------QVSAGTQLPVSQTVATVQGE----
Wnk2_Mmus PYLA-PTSQVVAPAQLKP--LQMPQPPLQPLAQVPPQM---PQMPVVPPITPLTGLDGLP
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap SQTS-TSS---EATTAQP--VSQPQAP-----QVLPQVSAGKQLPVSQPVPTIQGE----
Wnk2_Hsap PYLA-PASQVGAPAQLKP--LQMPQAPLQPLAQVPPQM---PPIPVVPPITPLAGIDGLP
17822_Tthe NGLQ-NTKQYSKDSQT----------------------SQITQIEIKNKSQEVEDKINTP
8961_Tthe IFKQ-DQSELDTPV------------------------------DLRQISQKEQKITQQT
WNK_Spur PQLVSQSSQQPSTTAVLPQQDQAQQQPMQPSAQQP-------------PISNVQQQ----
AqueK219_Aque -----------------------------------------------------TGVGGAG
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe -----DGSH---------------------------------------------------
WNK_d_Smoe -----DETR---------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele -------PTSAQ-P-------Q--PV--L--------------S-----PT---------
CG7177_Dmel --QQQQVAVSHQ-Q-------QIMQQ--Q--------------L------AQH-QLQQLQ
Wnk1_Mmus ----PHIPVSTQ-P-------SVVPV--H--------------S------GAH-FLP---
Wnk2_Mmus Q-TLTDLPAANV-A-------PVPPPQYF--------------S------PAV-ILP---
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ----PQIPVATQ-P-------SVVPV--H--------------S------GAH-FLP---
Wnk2_Hsap P-ALPDLPTATV-P-------PVPPPQYF--------------S------PAV-ILP---
17822_Tthe S-QVQDLDSLNI-K-------ATPQITEK--------------S------NSDQVQN---
8961_Tthe P-KGSDIFSINN-SQINSSNYDIPQFKNNNGFKFIQDQQVYEES------GNFSIAS---
WNK_Spur ----PTIPAQQQ-S-------QPQQI--Q--------------QQPPQQQ--Q-LQQHQI
AqueK219_Aque GGVGSEGPSASNSP-------NVPHKITG--------------G------TAM-TTP---
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------S---AAVPVPTTM-----------------------
CG7177_Dmel QQQLQQQQLQQQQQIQQQQLQQQQL---QQQQFVQQYAQ-------AMPQQQHQQLVTGS
Wnk1_Mmus ----------------------------MGQPIPTSLLP-------QYPV---------S
Wnk2_Mmus ------------------------S---LTTPLPT--SP-------ALPM---------Q
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ----------------------------VGQPLPTPLLP-------QYPV---------S
Wnk2_Hsap ------------------------S---LAAPLPPA-SP-------ALPL---------Q
17822_Tthe ------------------------EQTT---ALEE--NK-------EQLL---------Q
8961_Tthe ------------------------ETPDLGCNL-----NNCQTNIEQQEY---------E
WNK_Spur QQQQQHQAQHQQQQQQPQSTPHSQS---QLQPQPQQ-SV-------QQPV---------Q
AqueK219_Aque ------------------------S---ENSEDSEK-ES-------VEDE---------Q
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele --IHVPKPS-------------EIPVQ---------------------------------
CG7177_Dmel Q-VMAPHQHQQPIQIPVQMQVPPTSVAPPIQ-----HTYNQQGGQVTL------------
Wnk1_Mmus ----------------------QIPISTP-------HVSTAQTGFSSVPITMAAGINQPL
Wnk2_Mmus A-VKLPHPPGTPLAVPCQTIVPNAPAAIP-------LLAVAPQGVAALSIHPAVA-QIPA
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ----------------------QIPISTP-------HVSTAQTGFSSLPITMAAGITQPL
Wnk2_Hsap A-VKLPHPPGAPLAMPCRTIVPNAPATIP-------LLAVAPPGVAALSIHSAVA-QLPG
17822_Tthe A-NQNEHL----------------------------------------------------
8961_Tthe T-SKYDPI----------------------------------------------------
WNK_Spur TQAQVQVPTQLPQSLPSQQQQQQQQAQTQQFVQQTANYTQFPQGQA-YQQSVSQG-QLPQ
AqueK219_Aque F-VSKKHSELTSAPVSSK-SLPSSSKTSP-------NLSKGKGGEEEREEHQSLS-AKGQ
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -----------------------------------ALQPPGGVPSS--------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele -NVA-----TTAAP--VAAN--NVP-PSPA------------------------------
CG7177_Dmel ---------SDAQQ-QQHPGFSAVP-QQA----APFIQQPTQQPIQ-------LS---MP
Wnk1_Mmus LTLA-----SSATA-SSIPG--GSP-VVPNQ-LPTLLQPVNQLQSQ--------------
Wnk2_Mmus QPVY-----PAAFP-QMVPG--DIP-PSPHHTVQSLRATPPQLASP--------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus -----------------------------------ALQPPGGLPSS--------------
Wnk1_Hsap LTLA-----SSATT-AAIPG--VST-VVPSQ-LPTLLQPVTQLPSQ--------------
Wnk2_Hsap QPVY-----PAAFP-QMAPT--DVP-PSPHHTVQNMRATPPQPALP-----PQPTLPPQP
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur QPIQQPLQQPIQQP-LQQPS--QVP-STPQRTASDQHAKVTRTVSGGSQHAPQPQVQPQA
AqueK219_Aque GDIV-----NRTYSEDVHQS--DLSSGSATNS----------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele --------------------------------------------PFKTEDI---------
CG7177_Dmel LE-------Q------------------------------QLQQLLHSQPAQQQQA----
Wnk1_Mmus ---------------------------------------------VHPQLLQPTTVQSIG
Wnk2_Mmus ---------------------------------------------VPPQPVQPSV-IH--
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ---------------------------------------------VHPQLLQPA-VQSMG
Wnk2_Hsap VLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQP----H--
17822_Tthe ---------------------------------------------------NQESQQQVN
8961_Tthe ---------------------------------------------------NQQNANQLE
WNK_Spur ------------------------------------------------------------
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam -----------------------------------------------HVPAN--------
Wnk4_Hsap ---------------------------------------L-AESHLC--LPSAFALSIPR
Wnk3_Hsap --LVQGQS----------------------------TVLP--------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel ----MSQQ----------------------------QQQP-LVQQQQLPLVQQQPPLVQQ
Wnk1_Mmus IPANLGQA----------------------------AEGP-LPSGDV--LYQGFPSRLPP
Wnk2_Mmus LP----EQ----------------------------AAPT-AASGTQ--VLLGH----PP
Wnk3_Mmus --VVQGQS----------------------------SVMP--------------------
Wnk4_Mmus ---------------------------------------P-AESHLC--LPSGFALSIPR
Wnk1_Hsap IPANLGQA----------------------------AEVP-LSSGDV--LYQGFPPRLPP
Wnk2_Hsap LP----EQ----------------------------AAPA-ATPGSQ--ILLGH----PA
17822_Tthe QEQNIQKDDKQN-SHEEHNDDEN--DNLKQKYYMNKN-----------------------
8961_Tthe SEQIMQNDS-QNMKSNSDGSSQTSSMSINQGIYLN-------------------------
WNK_Spur ------TQ----------------------------SQPIQQ-------QMQ----LLPP
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap S-----------------------------------------------------------
Wnk3_Hsap VHVLGP------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------QTPTLA
CG7177_Dmel QQPLVQHQQPSV------------------------------------------------
Wnk1_Mmus QYPGDSNIAPSSNVASVCIHS-TVLAPPSMP--------------TEAL-ATQGYFPTVV
Wnk2_Mmus SYTAD----VAAPVSAVSLPP-AVLSPP-LP--------------DTLLPTVPDLLPKVP
Wnk3_Mmus IYAAGV------------------------------------------------------
Wnk4_Mmus S-----------------------------------------------------------
Wnk1_Hsap QYPGDSNIAPSSNVASVCIHS-TVLSPP-MP--------------TEVL-ATPGYFPTVV
Wnk2_Hsap PYAVD----VAAQVPTVPVPPAAVLSPP-LP--------------EVLLPAAPELLPQFP
17822_Tthe -------IIFTNNNGMIT----QILPAPEKRLDEEFKMRKITEDSKEI-QEEDRLYDNNI
8961_Tthe ----------------------------------------------------------TI
WNK_Spur SQS-----AQQQQHASVTNTT-SVLKQS-IP--------------ATQQSGQPSHVPQVC
AqueK219_Aque -------------TQSINVNS-VSDATPT----------------GKDL-ARSASFYSGS
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap -------------------T--VVSQPQV-------------------------------
C46C2.1_Cele QNTVPRT-----------------------------------------------------
CG7177_Dmel ---------------QHQQP--LVQQPQ--------------------------------
Wnk1_Mmus QPYVESTPLVPMGSVG-GQV--QVSQPAV-------------------------------
Wnk2_Mmus SS----------------------------------------------------------
Wnk3_Mmus -------------------G--VVSQSQI-------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap QPYVESNLLVPMGGVG-GQV--QVSQPGG-------------------------------
Wnk2_Hsap SS----------------------------------------------------------
17822_Tthe QSRVQNNDSISFYNQG-GKNSENISFSQIN-----------ASNAKEVVE--DFSFDKQT
8961_Tthe N-------------------------YSLAFNEYSQDTQYRYAFT-LEIRDSLYPFDITV
WNK_Spur QNSVQQTQQQQIQQVGQGQP--QQQQQQQ-------------------------------
AqueK219_Aque QTQSETQTLIA--------------HSQT-------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ----------------------------------------SPLTV---------------
C46C2.1_Cele ------------------------------ISTDASGL--VINTP---------------
CG7177_Dmel ---------------------------QQQPQPQNQQPQPQTQQT-HVV--QQQPPQQQP
Wnk1_Mmus ------------------------SLTQQPPTTSSQQA--VLEST---------------
Wnk2_Mmus -------------------------LAP-TVVAASQSA--PAQTSSLLL--PTNP-----
Wnk3_Mmus ----------------------------------------SPLTI---------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------------------------SLAQ-APTTSSQQA--VLEST---------------
Wnk2_Hsap -------------------------LAT-V-SASVQSV--PTQTATLLP--PANP-----
17822_Tthe K--------------TQIIDKKLEQQEEQKQTQNSQVL--IIDSAQNRRDIQSADFSQSP
8961_Tthe DKNLINNGSYNKESITNLIKEALNQIECQDL-EKLHNF--IIDDAVAKCKLLFKD-----
WNK_Spur ------------------------QQ--QQQQQQQQQQ--QLQQL--QQ--QQQQPQHHP
AqueK219_Aque ------------------------S---LSGTAVSQSI--AAQSSSGSA--QSQT-----
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap -----------------------QKVPQIKPV----------------------------
C46C2.1_Cele -----------------------ASIASPSPA----------------------------
CG7177_Dmel AVE------------------QISQISSQVPVQ---------------------------
Wnk1_Mmus -----------------------QGVSQAAP-----------------------------
Wnk2_Mmus PLP------------------TGPAVAGPCPA----------------------------
Wnk3_Mmus -----------------------QKVSQIKPV----------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap -----------------------QGVSQVAP-----------------------------
Wnk2_Hsap PLP------------------GGPGIASPCPT----------------------------
17822_Tthe ----------------------------NYHTKKSEGNNTPITPIVNNILYAFKNPQSDE
8961_Tthe ---------------------------------------------INNAYFMFMNLVSEF
WNK_Spur IQPGTTLGQPHMMSAPSYVSIAASSAAAVAT-----------------------------
AqueK219_Aque --T------------------SSSSISSGYHSQ---------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus ------------------------------------------------------------
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------------------------------------------------------------
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe K---------HKLIRQKSKSGEDFYVQKLQNIQNEDIQVSYSENLSMNGLQNNQQEYSK-
8961_Tthe QAKKKKFNKKE------------------------EM--AKKNSLSPSKSSNFQLNLTPD
WNK_Spur ------------------------------------------------------------
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap --------------------S--------------------------------------Q
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel -----------------QENL--------------------------------------Q
Wnk1_Mmus --------------------P--------------------------------------E
Wnk2_Mmus ----------------VQLMV--------------------------------------E
Wnk3_Mmus --------------------S--------------------------------------Q
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap --------------------A--------------------------------------E
Wnk2_Hsap ----------------VQLTV--------------------------------------E
17822_Tthe -----------------------------PSKGQSPKKIQDQLTNDQQYERILRRENDMN
8961_Tthe EKKQSLQQIQANISTNQQILVAKAIQDDDDDDNNSDHEIEDAVFYNA---YCDDYNR---
WNK_Spur --------------------A--------------------------------------V
AqueK219_Aque ----------------S---S--------------------------------------S
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ----------------------GPGSDF--------------------------------
Wnk3_Hsap PVGAEQ-----------Q-AALLKPD----------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel PIQV--------------NKDANVATDA--------------------------------
Wnk1_Mmus QTPITQ-----------S-QPTQPVPLV--------------------------------
Wnk2_Mmus VAQEEQ-----------VSQDKPPGPPQ--------------------------------
Wnk3_Mmus PIGAEQ-----------Q-ATLQNPD----------------------------------
Wnk4_Mmus ----------------------GPGSDF--------------------------------
Wnk1_Hsap PVAVAQ-----------T-QATQPTTLA--------------------------------
Wnk2_Hsap PVQEEQ-----------ASQDKPPGLPQ--------------------------------
17822_Tthe -------------------------NSQKNENLNSQNNLQNI---GGVEHSE-FI-----
8961_Tthe -----------------------------------QDEYNHISSHNPQEYTQNQIYYQNN
WNK_Spur PVSLATTTSNASAPAWHLAQDNRPQTVD--------------------------------
AqueK219_Aque ALALS------------SSSSTPPS-----------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam -----------------------LDTAS--------------------------------
Wnk4_Hsap -SPGDSYASDAA----SG-------------LSDVGEGM----------GQMRRP-PGRN
Wnk3_Hsap --LVRSLNQDVA----TTK-----------ENVS-SPDN-PSGNGKQ----DRIK-QRRA
C46C2.1_Cele ----P-SATDVA----STTAPVTPAPTP-TTTTDGGAAA-AS--------TTT---EN--
CG7177_Dmel -MSLNSAHGA--LEPAPKT-------EPQ-NSADAEKQQKQTGTG------TR----SQK
Wnk1_Mmus -TSADSAHSDVA----SG-------------MSDGNENA-PSSSGRHEGRTTKRH-YRKS
Wnk2_Mmus -SSESFGGSDVT----SGR-----------DLSDSCEG--TFGGGRLEGRTARKH-HRRS
Wnk3_Mmus --FVRSLNQDVT----SVK-----------ENTN-NPDT-PSGNGKQ----DRNK-QRRA
Wnk4_Mmus -SPGDSYASDAA----SG-------------LSDMGEG-----------GQMRKN-PVKT
Wnk1_Hsap -SSVDSAHSDVA----SG-------------MSDGNENV-PSSSGRHEGRTTKRH-YRKS
Wnk2_Hsap -SCESYGGSDVT----SGK-----------ELSDSCEG--AFGGGRLEGRAARKH-HRRS
17822_Tthe -------------------------------------------SNQESGASLDKY-SNKS
8961_Tthe YSRLDNTQNNIK----N-----------------DHLTH-QTSEPSHQNHSRQQS-YI--
WNK_Spur -AS--KVGSDGQAWSSPGLE-------RKDVLTDAASAY-PSGTGEESGAEGSQNVEKRQ
AqueK219_Aque -VEADTTQSNGS----SG----------------------PGGSGG----SFR-------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam -----SVV--------------------------------------------I---KRRP
Wnk4_Hsap -------------------------------------------------------L----
Wnk3_Hsap -------------------------------------------------------S--CP
C46C2.1_Cele --------------------------------------------------------KEEK
CG7177_Dmel -------------------------------------------------------PRRSN
Wnk1_Mmus -------------------------------------------------------VRSRS
Wnk2_Mmus -------------------------------------------------------TRARS
Wnk3_Mmus -------------------------------------------------------S--CP
Wnk4_Mmus -------------------------------------------------------L----
Wnk1_Hsap -------------------------------------------------------VRSRS
Wnk2_Hsap -------------------------------------------------------TRARS
17822_Tthe LENTNNDSNKRASPSNGVVYYDDLANQFTMQNDHSDIYSNHEYQQDYSKQPSMVEIQQYQ
8961_Tthe ---------------------------------------------------SSHSVQLNS
WNK_Spur ---------------------------------------------------------GKK
AqueK219_Aque -------------------------------------------------------SKKGS
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam -------------------------------------------------------TKSSL
Wnk4_Hsap --RR--RPRSR--LRVTSVSD-QNDRVVECQL-QTHNSK-MVTFRFDLD-GDSPEEIAA-
Wnk3_Hsap RPEK--GTKFQ--LTVLQVST-SGDNMVECQL-ETHNNK-MVTFKFDVD-GDAPEDIAD-
C46C2.1_Cele RKSN--KRKVV--MEILGCDESRNFALVSCRL-DTS-HK-SVTFQFAPG-TDKPCTIAT-
CG7177_Dmel RSG--NERIPK--LSVTSV---DEGSVINCHM-EN-KLK-TITFKFDIGDRDETASDIT-
Wnk1_Mmus RHEK--TSRPK--LRILNVSN-KGDRVVECQL-ETHNRK-MVTFKFDLD-GDNPEEIAT-
Wnk2_Mmus RQER--ASRPR--LTILNVCN-TGDKMVECQL-ETHNHK-MVTFKFDLD-GDAPDEIAT-
Wnk3_Mmus RPEK--GTKFQ--LTVLQVSV-SGDNMVECQL-ETHNNK-MVTFKFDVD-GDAPEDIAD-
Wnk4_Mmus --RR--RPRSR--LRVTSVSD-QSDRVVECQL-QTHNSK-MVTFRFDLD-GDSPEEIAA-
Wnk1_Hsap RHEK--TSRPK--LRILNVSN-KGDRVVECQL-ETHNRK-MVTFKFDLD-GDNPEEIAT-
Wnk2_Hsap RQER--ASRPR--LTILNVCN-TGDKMVECQL-ETHNHK-MVTFKFDLD-GDAPDEIAT-
17822_Tthe DQES--NDVPPYSLTVLEEK-ELKNQKFLIKFKFQHFNR-MQTFEIDNT-HEDFSEQSIF
8961_Tthe IQEQ--TQNF--KFM------NANPQYFNNQQQ-NKNSQNIQLFSIDSH-NQKNSPAIPQ
WNK_Spur KHSKTSKKRPK--LSIIS--V-DEDQVIECSL-ETHRGD-TIVFKFSED--DQLDGIVS-
AqueK219_Aque RTKD--SKRIK--LKFN--EK-VKDNVISCSL-QTSAGQ-VINFKFSLD-YDKPNEIFN-
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam TSR--IN--------------------VE----IS-LPN-QVSFVYVLSLMDKPVEIVD-
Wnk4_Hsap ----AMVYNEFIL-----------------------------------------------
Wnk3_Hsap ----YMVEDNFVL-----------------------------------------------
C46C2.1_Cele ----KLLAEDCLL-----------------------------------------------
CG7177_Dmel ----KMFEP---------------------------------------------------
Wnk1_Mmus ----IMVNNDFIL-----------------------------------------------
Wnk2_Mmus ----YMVEHDFIL-----------------------------------------------
Wnk3_Mmus ----YMVEDNFVL-----------------------------------------------
Wnk4_Mmus ----AMVYNEFIL-----------------------------------------------
Wnk1_Hsap ----IMVNNDFIL-----------------------------------------------
Wnk2_Hsap ----YMVEHDFIL-----------------------------------------------
17822_Tthe AFAQIKAAELEIVDLEEQFAYDLYNLVYERYNQFHSQVSQGQRKIVQED--------SSS
8961_Tthe SVQK-------------------------------------NQIFPTPPQFSEKNQCQSP
WNK_Spur ----NLTVAKWVH-----------------------------------------------
AqueK219_Aque ----NLVKTGHLS-----------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ----ELEMVH--------------------------------------------------
Wnk4_Hsap ------PSERDGFLRRIREIIQRVETLLKRDTGP-MEAAEDTLSPQ--------------
Wnk3_Hsap ------ESEKEKFVEELRAIVGQAQEILHVHFAT-ERA--TGVDSITVDSNSS-------
C46C2.1_Cele ------KVHVHIVEAQLGEVIQLINSDGKKGVGT-KLATV--LDP---------------
CG7177_Dmel -------------------TIHGVETLPSGGGGA-EQ-----------SNCNLT--LE--
Wnk1_Mmus ------AIERESFVAQVREIIEKADEMLSEDVSV-EPEGDQGLESLQGKDDYG-------
Wnk2_Mmus ------PAERETFIEQMKDVMDKAEDMLSEDTDA-DHGSDTGTSPPHLGTCGL-------
Wnk3_Mmus ------ENEKEKFVEELRAIVGQAQEILHVHSAV-EKS--IGVDSVALESNSN-------
Wnk4_Mmus ------PSERDGFLSRIREIIQRVETLLKRDAGP-PEAAEDALSPQ--------------
Wnk1_Hsap ------AIERESFVDQVREIIEKADEMLSEDVSV-EPEGDQGLESLQGKDDYG-------
Wnk2_Hsap ------QAERETFIEQMKDVMDKAEDMLSEDTDA-DRGSDPGTSPPHLSTCGL-------
17822_Tthe PN-YTQPYCIEIFIRHYQNYMKEIEEYLKVESSH-NLKVRQSKEQIQLHRFHLN--QQE-
8961_Tthe PNHYNFCKLIDNFIDYYKKYWEQNYEQISYETQE-LLKFRQQKELIELQRLHIA--QRDA
WNK_Spur ------EQHAGLFKEQLLKVMEDAKRLG-PGLHL-QP----GPSSSTVGDDTG-------
AqueK219_Aque ------QLEGTDFISQFQKVVDTVRSKSTVDSTSSDTKKNPG-GPLRSTSVSYSSIVK--
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam -------------------D----------------------------------------
Wnk4_Hsap ------------------------------------EEPA-PLPA-------------LP
Wnk3_Hsap -------------------------QTGSSE-------------QVQINSTSTQTSNE--
C46C2.1_Cele ----------------------------------NSTEPP-TITAV------------MP
CG7177_Dmel ---ARS------------------------------------------------------
Wnk1_Mmus -------------------------FPGSQKLEGEFKQPI-AVSS-------------MP
Wnk2_Mmus -------------------------ATGEENR---------------------------Q
Wnk3_Mmus -------------------------QTGSSE-------------QVLINSASTQTSNE--
Wnk4_Mmus ------------------------------------EEPA-ALPA-------------LP
Wnk1_Hsap -------------------------FSGSQKLEGEFKQPI-PASS-------------MP
Wnk2_Hsap -------------------------GTGEESR---------------------------Q
17822_Tthe -------------------NQIDYESQAQSQIVQKSPQTIQKVVA-------------VN
8961_Tthe WLTN--QMNLTANQYE---KQDAFQLQGKQGIQSQSNFII-YQSD-------------QA
WNK_Spur -------------------------TITSQQLQEGVVPPS-PGTAVNSSDASPPSGDESQ
AqueK219_Aque ---QDSDQSKHSESYQKGGARSDSPYDGSGQLGGVKRDGL-A------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap V-----------PLP-----------------------------DPSNEELQSST-----
Wnk3_Hsap --------------SAPQS-----SPVGRWRFC--------INQTIR-------------
C46C2.1_Cele K-----------DSS---------------------------------------------
CG7177_Dmel ----------------------------------------HLSNIPNAKEPQLNVS----
Wnk1_Mmus Q-----------QIGVPTSSLTQVVHSAGRRFI--------VSPVPESRLRESKV-----
Wnk2_Mmus S-----------QANAPVYQ-QNVLHTGKRWFI--------ICPVAEHPAT---------
Wnk3_Mmus --------------SAPQS-----SPVGRWRFC--------INQTIK-------------
Wnk4_Mmus --------------------------------------------GPPNAEPQRSI-----
Wnk1_Hsap Q-----------QIGIPTSSLTQVVHSAGRRFI--------VSPVPESRLRESKV-----
Wnk2_Hsap S-----------QANAPVYQ-QNVLHTGKRWFI--------ICPVAEHPAP---------
17822_Tthe Q-----------QQLLPQQNINYANNSNNQDFF--------ESPE---------------
8961_Tthe NNIQTNHSVLDISNISNVKDIDNDNHISPQLK----------------------------
WNK_Spur Q-----------QLNAPQQSFE--MAVGKHLTAESQQGEQQLRPVENQHLPLSRKGSSPL
AqueK219_Aque --------------------LSEASPHSRRKFQ--------VSDVFV-------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -------SLEHRSWTAFSTSSSSPGTPLSPGN----------------------------
Wnk3_Hsap -----------------NRETQSPPSL-Q---HS------MSAVPG--------------
C46C2.1_Cele ---------------AATASNTKPKIEIEKTPPT----RDASQEPN-NVQVT---NVRKV
CG7177_Dmel ----------------------TPPTTTSTMSSSSTASRDAPNSSN-DVTIGSGSVSRKT
Wnk1_Mmus -------FTSDISDPVVASTSQAPGMNLSHSASS--------------------------
Wnk2_Mmus -----------------DTSESSPPLPLSSLQPE------ASQDP---------------
Wnk3_Mmus -----------------NREAQSPPSL-Q---PS------MAMVPG--------------
Wnk4_Mmus -------SPEQRSWAAFSTSPSSPGTPLSPGA----------------------------
Wnk1_Hsap -------FPSEITDTVAASTAQSPGMNLSHSASS--------------------------
Wnk2_Hsap -----------------EAPESSPPLPLSSLPPE------ASQGPCRGLTLPCL-PWRRA
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur IVNQPQQMGSEDSDQTRPKPNQSPPAAIENMPSQ--------------------------
AqueK219_Aque -----------------ERPNEKPSITSQGSAES--------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -----------------------PFSPGTP---------------IS--PGPIFP---IT
Wnk3_Hsap -----------RH----------------P----L--PSP--KNTS--------------
C46C2.1_Cele SQE-----S---------N-AESVQSIPRPGGIIV--MSP--TNQTDSAPPPTGA---AA
CG7177_Dmel STASEYTSLSI--------D----YMPDSNI--TPTGPEPPLDDG--KDKKPCSLAIARM
Wnk1_Mmus --------LSLQQAF---SELKHGQMTEGP----N--TAP--PNFNH-MAGPTF------
Wnk2_Mmus ----------------------------------A--PYP--DQLSL-TDKPSFP---AA
Wnk3_Mmus -----------LH----------------P----F--PSS--RNTS--------------
Wnk4_Mmus -----------------------PFSPGTP----P----------VF--PCPIFP---IT
Wnk1_Hsap --------LSLQQAF---SELRRAQMTEGP----N--TAP--PNFSH--TGPTFP---VV
Wnk2_Hsap ACG-----AVFLSLF---S-AESAQSKQPP----D--SAPYKDQLSS-KEQPSFL---AS
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur --------VPVQQSHHLQMELRT--------------------------PQPVYP---S-
AqueK219_Aque --------MTVMSPV---H-------SEDT----C------------I------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap -----------------------------------NKEISRDTLLTIENNPCHRALFTSK
C46C2.1_Cele KPSRFQVTKSADPIA-----------TPI-SSSIS-------------------------
CG7177_Dmel QKLLESAG-NGAPRSLN---------LPL-N-----------------------------
Wnk1_Mmus SPFLASIAGVQTVAAST-------PSVSVPITSSPLNDISTSVMQSETALPTEKGIVGVT
Wnk2_Mmus QQLLSQAGSSNPPGGAS---------APL-APSSPP------------------------
Wnk3_Mmus -----------------------------------NQAISQNTVFTIENNPGHRELFTSK
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap PPFLSSIAGVPTTAAAT---------APVPATSSPPNDISTSVIQSEVTVPTEEGIAGVA
Wnk2_Hsap QQLLSQAGPSNPPGAPP---------APL-APSSPP------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur -----QAGVPDQGMMQGMPMMGAYSMMPM-LSSQG-------------------------
AqueK219_Aque --------------------------LPPPSSSSSSSDNKST------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap -SEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVR---AVPAEC
C46C2.1_Cele ---------------------------------------------TATVIP---IVAATP
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus TTSTGVVASGGLTTMS-----------------------------VSE-SPTSSSAVSSS
Wnk2_Mmus ---------------------------------------------VTTVIP---AAPATS
Wnk3_Mmus -LDHKDVVDGKIGEHASIETEQSSISYQVEDDRQIMTPATDNSNYSAALVC---PVPGEC
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap T-STGVVTSGGLPIPP-----------------------------VSE-SPVLSSVVSSI
Wnk2_Hsap ---------------------------------------------VTA-LPQDGAAPATS
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ---------------------------------------------NVVF-----------
AqueK219_Aque ------------------------------------------------QDPT-SVFHSTS
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ---------------------------------------------------SPPCHPSPS
Wnk3_Hsap EGL-------TKQASIFIPVYPC----------------HQTASQADALMSHPGE-----
C46C2.1_Cele TNI-------TSEPVIVQPIT----------------------AQVITHLA----TP--S
CG7177_Dmel -----RHLKI-QEDLKHTRSL-DDLTAVKITFDMPNKAALDTSENAQQATEAEAEKPK--
Wnk1_Mmus TVPAVVTVST---PSQPVQAS-TSGSIASSTGSFPPGTFSTTTATTMGSVVAPDAKPPT-
Wnk2_Mmus TVPE----------------S-A----------------AGTAMQAGGPGTHQG------
Wnk3_Mmus EAL-------TSQAGMFMPTYPN----------------QQAAVLADVHIAYPGE-----
Wnk4_Mmus ---------------------------------------------------SPSCYPCP-
Wnk1_Hsap TIPAVVSISTTS-PSLQVPTS-TSEIVVSSTALYPSVTVSATSASAGGSTATPGPKPPA-
Wnk2_Hsap TMPE----------------P-A----------------SGTASQAGGPGTPQG------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur -VPMATQA--GAPQMYMHPQQ-A----------------QQMYMQQQ------------M
AqueK219_Aque VLPT----------------C-T----------------LGTGD-KGNLGDT----P--S
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap PFSPISSQVSS-------------------------------------------------
Wnk3_Hsap STQ---------------------------------------------------------
C46C2.1_Cele PVS---HSLSS-------------------------------------------------
CG7177_Dmel ---DKSGQAVG-------------------------------------------------
Wnk1_Mmus ---VLLQQVAS-------------------------------------------------
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus SVP---------------------------------------------------------
Wnk4_Mmus -----FSQVSS-------------------------------------------------
Wnk1_Hsap ---VVSQQAAG-------------------------------------------------
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur PMQ----QHLSQQPPMQQHQQPPMQQLQQQPPIMQHQQQPPMQQQQQPQQQLPMHQQQPP
AqueK219_Aque SVA---------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap --------------------NPSPHPTSS----PLPFSSSTPEFPVPLSQ----------
Wnk3_Hsap -------TSGNS-L-T-------------------TL-------------------AFDQ
C46C2.1_Cele --------------------NS------------SPSATTHSN-MSSIQS-------TTS
CG7177_Dmel -----NQG-TGA-----------ANTLEQLKIELENITHAHA-FASAVVA-------SIN
Wnk1_Mmus -----NTA-GVAIVTSVSTTTPFPGMASQ---PSLPLSSSTSA-PTLAET-------MVV
Wnk2_Mmus -----PAS-VHE--------------------TLQPLAETRSA-QCTAQP-------LST
Wnk3_Mmus -------IGGNAALTS------------------VLV-------------------SSDQ
Wnk4_Mmus --------------------NPYPQAPSS----LLPLSSSASQVPLP-------------
Wnk1_Hsap -----STT-VGATLTSVSTTTSFPSTASQ---LCIQLSSSTST-PTLAET-------VVV
Wnk2_Hsap -----LTS-ELE--------------------TSQPLAETHEA-PLAVQP-------LVV
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur MQQQPLPS-VQD--------------------QVQPLLQQQPTQP---------------
AqueK219_Aque -------T-GNS----------------------SAISSASSS-YSNLQPSGTGTITTVE
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap KPQTLSVQQPAMDAEFISQEGETT-----VNTEAS-------------------------
C46C2.1_Cele VPGRRFTVQPVSQAES-------G--------------ISSSISTPHPEPTPA-------
CG7177_Dmel --NRAP-HQASPAM----------------------------------------------
Wnk1_Mmus --SAHS-LD--------------------KASHSSTAGLGLSFCAPSSSSSSG-TAV-ST
Wnk2_Mmus --GQGP-CTPALEASRCST----GLGEPISTREVSTQGEPLPASVP--EPSPP-TGATQS
Wnk3_Mmus KPQSLSVQQPTIDAEFISKEGETT-----VNTETS-------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap --SAHS-LD--------------------KTSHSSTTGLAFSLSAPSSSSSPG-AGV-SS
Wnk2_Hsap --GLAP-CTPAPEAA--------------STRDASAPREPLPPPAP--EPSPH-SGTPQP
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ----------------------------IQQGGQQAQIPPQQLQQV--QPTQPGQQVATS
AqueK219_Aque APNKKFEIEDVIDPETLS-------------TE-SSCENLIPDDKA--E-----------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ---CP---WS--SLPTTSPPTFSPTCSQV-TLSSPF--FPPCPSTSSFPSTTAAPLLSLA
Wnk3_Hsap -------------------------SPK--TVIPT--------QTPG-------------
C46C2.1_Cele -----------------------------------I--TSCPPPVPSVPPVV-S------
CG7177_Dmel -----------------SSLKATSGQPQTQEITKPN--NGAGPSVPSVGQNTPTAALTSA
Wnk1_Mmus SVSQP---GMVHPLVISSAVVSTPGLPQ--PVVPTS--TPLLPQVPNIPPLV-QPV----
Wnk2_Mmus VPGQP---PPPLPITVGAISLAAPQ-----------------------------------
Wnk3_Mmus -------------------------SPK--AVIAT--------QTPG-------------
Wnk4_Mmus --------SS--SLPISAPLPFSPSYPQD-PLSPTS--LPVCPSPPSLPSTTAAPLLSLA
Wnk1_Hsap YISQP---GGLHPLVIPSVIASTPILPQ--AAGPTS--TPLLPQVPSIPPLV-QPV----
Wnk2_Hsap ALGQP---APLLPAAVGAVSLATSQ-----------------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur VQGQAHAQPHQQPQTTAALSTAAPT---Q-S----------------VAG-GAQPQQSQA
AqueK219_Aque --------------------------PKN-EVTPTESSTIIKDDEST-------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap SAFSLA------VMTVAQSLL-------------S-------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------NGTLNLEVA----------PKQTPSATNQNVDTQHSSSTASTA--TLV
CG7177_Dmel RGSGSS------VYNSRRTSI--DNSVGSDMHLHTATNLEGTVSNP------DPIPTEAS
Wnk1_Mmus ----VN------VPAVQQTLI----------HS-Q-------------------------
Wnk2_Mmus ----------------------------------L-------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus SAFSLA------VMTVAQSLL-------------S-------------------------
Wnk1_Hsap ----AN------VPAVQQTLI----------HS-Q-------------------------
Wnk2_Hsap ----------------------------------L-------------------------
17822_Tthe ----------IN------------------------------------------------
8961_Tthe -----------D------------------------------------------------
WNK_Spur KAAQVAGVARLKELDHKLSQLHKKPNP----HQ-Q-------------------------
AqueK219_Aque ---------------------------------------SVELSTPPTFSDEDTLTYARV
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ----------PSPGLLSQSPPAPPSPL-----------P---------------------
Wnk3_Hsap --------------LEPTT-LQPTTVL-----------ESDGERP--------------P
C46C2.1_Cele S---------ETPATVHVTPISVPAP---------------VQE--------------PL
CG7177_Dmel VGITIATGHEKQLSKQPSLEKPSATSI-----------LTNNSDPPQRNPSNGSINQ---
Wnk1_Mmus ----------PQPALLPNQPHTHCPEM-----------D--ADTQ--------------S
Wnk2_Mmus ----------PSPPLGPTAPPPPPSAL-----------ESDGEGP-------------PP
Wnk3_Mmus --------------FEPAV-ILPATIL-----------ESDGERP--------------P
Wnk4_Mmus ----------PSPGLLSQSPPAPPGPL-----------P---------------------
Wnk1_Hsap ----------PQPALLPNQPHTHCPEV-----------D--SDTQ--------------P
Wnk2_Hsap ----------PSPPLGPTVPPQPPSAL-----------ESDGEGP-------------PP
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ----------QTPAKVPSQPPTMLQQQ-----------ISQ--GQ--------------S
AqueK219_Aque KEV--ESSSKPHPPTSTNPPMYPPYSVQPVDPPQPLLLSPFSRIP----PTHGTLLENPL
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap KLEFADNRIKTLDEKLRNLLYQEHSISS-IYPESQKDTQSIDSPFSSSAEDTLSCPV---
C46C2.1_Cele VIDHHSDVLTQLDSELRKVSGVSHSAS---------------------------------
CG7177_Dmel ------NSIADLEKKLAALRNTENTEEARTQ----HVSR---------------------
Wnk1_Mmus KAPGID-DIKTLEEKLRSL-FSEHSSSG-TQ----HASVSLETPLVVE--TTVTP-----
Wnk2_Mmus RVGFVDNTIKSLDEKLRTLLYQEHVPTS-SA----SAGTPMEASD-RD--FTLEP-----
Wnk3_Mmus KMEFADNRIKTLDEKLRNLLYQEHSISS-ICPESQKDTQSIDSPFSSSAEDILSYSM---
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap KAPGID-DIKTLEEKLRSL-FSEHSSSG-AQ----HASVSLETSLVIE--STVTP-----
Wnk2_Hsap RVGFVDSTIKSLDEKLRTLLYQEHVPTS-SA----SAGTPVEVGD-RD--FTLEP-----
17822_Tthe ----------NIQKKANNLNQ--QAIEQ-FQQPLYQNNQNINSGIGNIPNNALITNNNNN
8961_Tthe ----------SIDMELSNMLLD-NPSSN-ILGNNYSKTHSQQ-IHQSSLHNSLSLNT---
WNK_Spur NVPYH-----------------NQVSVS-VA----QLTTPNNSQSSAN--IVLTP-----
AqueK219_Aque V---FD-GFMKFMHYMKLL-FEEPSIAA--L----LQQISINN-----------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ----T--EVIAISHCGIK--------------------------DSPVQSPNFQQTGS-K
C46C2.1_Cele --------------------------------------------------------PS-T
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus ---------------GIT--------------------------TT-------AVAPS-K
Wnk2_Mmus --------------------------------------------LR-------GDLPS-A
Wnk3_Mmus ----P--EVIAISHCGIQ--------------------------DSPAQSPNFQQTGS-K
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ---------------GIP--------------------------TT-------AVAPS-K
Wnk2_Hsap --------------------------------------------LR-------GDQPR-S
17822_Tthe MNQNYNQNSTSYSNIGIT--------------------------NNNSNIPNNAIPGS-L
8961_Tthe ----ANQNNLGL-MQQIQ--------------------------VEAIISPSNQSIGNQQ
WNK_Spur ---------------QPVSNMLAPVFHPIQDERKASLMDAQSLPIH-------NYLPR-P
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap LLSNVAA------SQPANISVFKRDLNVITSVPS-------ELC----------------
C46C2.1_Cele VVESLTS---------------------M--TPQ-------TIP----------------
CG7177_Dmel -------VQEQK------------------------------------------------
Wnk1_Mmus LMTSTTS------T-------------CL--PPT-------SLP----------------
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus ILSNVAA------SQPAHISVFKKDLNVITSVPS-------ELC----------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap LLTSTTS------T-------------CL--PPT-------NLP----------------
Wnk2_Hsap -----------------------------------------EVC----------------
17822_Tthe LNFNSNQ------NTQGNI------------------------ASHHLSPNSSANTFEEN
8961_Tthe FIQNMQT------SEP----------------------------------TTSASISNKK
WNK_Spur ASEPVPDFQTTPYV-------------DP--QQDSVQVVPEKSE----------------
AqueK219_Aque -------------P-------------DQ--PPSSGSTANGHTP----------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe -------------FASGNI-------------------------KRHLSPQ---------
WNK_d_Smoe -------------TES-----------------------------PTVEAG---------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ----------------------------------------------TVSSR---------
WNK_b-1_Smoe ----------------------------------------------TVSSR---------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ----------------------SLPLPPPVAPGGQESPSPH-------------------
Wnk3_Hsap --------------LHEMSSDASLPGDPEAYPAAVSSGGAIHLQT---------------
C46C2.1_Cele --------------L----ACQTVPASIGQAPAVIAA--AHAA-----------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus --------------L----GAAGMPVMPVGTPGQVSTPGTHASAP---------------
Wnk2_Mmus ---------------------------LS-------------------------------
Wnk3_Mmus --------------LHEMSPDASLPGDPEAYPAAVSSDGTIHLQT---------------
Wnk4_Mmus ----------------------SLPLS--LASCDQESLSAQ-------------------
Wnk1_Hsap --------------L----GTVALPVTPVVTPGQVSTPVSTTT-----------------
Wnk2_Hsap --------------G----GDLALPPVPK-------------------------------
17822_Tthe QEAQLQINFPPQ----------------------IQRSGSIQINAQSTQQNNMKNQIYIP
8961_Tthe TNLPIRTPTPKQTLNES-----------------ISQKQSQ-------------------
WNK_Spur --------------------ENQI----------------QIEQP---------------
AqueK219_Aque --------------S----NGQ----SPTATNGYAPAPGSNGH-----------------
WNK_e_Smoe ----MHSTDST-------------------------------------------------
WNK_a_Smoe -LPCVDVASPP-------------------------------------------------
WNK_d_Smoe -QASVKSRSPR-------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe -NSEVESLSPQ-------------------------------------------------
WNK_b-1_Smoe -NSEVESLSPQ-------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ----------------------------------------------------------GG
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus ----------------------------------------------------------VG
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus ----------------------------------------------------------GG
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------------------------------------------------------------
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe QNNQYQIQLPQIVNKNQYAQTTTHQQQQQQIKQKYLKEEMLNAQSFNPREGRQDNKGISH
8961_Tthe -----------------------------------------SIQSKNSQQNQNPQLAVNS
WNK_Spur ----------------------------------------------------------A-
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap GY--FGL--S--------------------------------------------------
C46C2.1_Cele --S---LIPN--------------------------------------------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus TAT--GVKP---------------------------------------------------
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus GY--FGL--S--------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap --S--GVKP---------------------------------------------------
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe SQ--SFS--NISTQAIQKVKQSQSKHRLHHAENSNAQGMYSSNQQSQPINKSQTQQLSYF
8961_Tthe YS--QNL--NNTQNSIQNQNNLNSNNEKIKTNTIN--SSNSSIIQTQPIRTHH-------
WNK_Spur --RPVSPKP---------------------------------------------------
AqueK219_Aque --S--AVNPA--------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe -----T------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus ------------------------------------------------------------
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------------------------------------------------------------
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe NQQNLSQQIQFQNPMQHQQQQQNSNFFQQGQQQQISQVNNSNYIFPQNNASQNMQQ-TPQ
8961_Tthe ----GSIQISMQNPKTNNKMQQSDKLYYQNPLQQQ---------------QQ---L-QQQ
WNK_Spur ------------------------------------------------------------
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe -----------------------------------------------------GPLSYSP
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------FTCPSLKNPISKK----SW-----
C46C2.1_Cele ------------------------------------ASVPQSPSR--LDAETG-------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus ------------------------------------GTTPPK--P--TKTVVPPV-----
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus ------------------------------------FTCPSLKNPISRK----SW-----
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------------------------------------GTAPSKPPL--TKAPVLPV-----
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe SFPGRQ---LNQRQQKYS-YASEDTQQN---QQS--------------NLIKQGSHFKNQ
8961_Tthe QQHFNP-QQQQQQFQQQT----FPQSSQQQIQQNKMNSKPPTP----KQIIS--------
WNK_Spur ------------------------------------ASSPTKKSR----FSVSSV-----
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe HGEG---M-MFGRFEEVSV-GCLSTDTDSEP-----------------------------
WNK_a_Smoe RGEG---T-MYGRFEEVYSGGSDPSEANAF--------------------------F---
WNK_d_Smoe RLEGTSSS-MHGRFEEVTY-HPEGSDQYDAPH-----------------------IF---
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe NLEG---T-MHGRFEEFTY-QSLPMRSHATP-----------------------------
WNK_b-1_Smoe NLEG---T-MHGRFEEFTY-QSLPMRSHATP-----------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap -------------------TRKLKSWAY--------RLRQS-------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus -------------------GTELSAGTV--------PCEQL-------------------
Wnk2_Mmus ---------------------D--------------------------------------
Wnk3_Mmus -------------------TRKLKSWAY--------RLRQS-------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap -------------------GTELPAGTL--------PSEQL-------------------
Wnk2_Hsap ---------------------E--------------------------------------
17822_Tthe SNHQVKLSSSQEQYTSK----------TPNIQDDSNNPYQL-------------------
8961_Tthe ----------------QNNNFHFSNNLT--------PSSQV-------------------
WNK_Spur -------------------EDKKDAAAV--------TEE-KPKEEISEGNAGSKTETVGD
AqueK219_Aque --------------------------------------HMR-------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap --TSFF------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus --PPFP------------------------------------------------------
Wnk2_Mmus -----K------------------------------------------------------
Wnk3_Mmus --TSFF------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap --PPFP------------------------------------------------------
Wnk2_Hsap -----A------------------------------------------------------
17822_Tthe --PQQQQRQQQQNQQPQYQQHASH---STQLENDNSIRKNSQNNGQSNYNAINPPFFIQP
8961_Tthe --AQQPLKPIKHNQQQV-KQNFIH---SATNSQDSSY------------FS--FQ-FMNE
WNK_Spur KSSREP------------------------------------------------------
AqueK219_Aque --PPV-------------------------------------------------------
WNK_e_Smoe ----------EPT--TG-LDNNGH---FSPAEE---------------------------
WNK_a_Smoe ---------SNESSDDG-EETSFP---ATPKSD---------------------------
WNK_d_Smoe ------SSGSSEIREDG-DDWDLTGEVSSPVAT---------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ----------RENQETA-KLWDFH---STPVPD---------------------------
WNK_b-1_Smoe ----------RENQETA-KLWDFH---STPVPD---------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap -----K--------RSKVRQ--VETE-E-MRSAIAPDPIPLT--------RESTADTRAL
C46C2.1_Cele --------LAG--LHEKLEA--LKMEQD-RREDMGDDAIGTT--------TTDGKDEIPI
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus -----GPSLIQ--SQQPLED--LD--AQ-LRRTLSPETITVAPAVGPLSTMSSTTVTEAG
Wnk2_Mmus -----TPSLTQ--QTQPSLE-----------------KSETAPAGWA-------------
Wnk3_Mmus -----K--------RSKVRQ--VETE-D-KRSAIASDPIPLT--------REFSSDTRAL
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap -----GPSLTQ--SQQPLED--LD--AQ-LRRTLSPEMITVTSAVGPVSMAAPTAITEAG
Wnk2_Hsap -----VSGRVQ--LPQPLVE-----------------KSELAPTRGA-------------
17822_Tthe LDNKNGNQFTQGISQQNLKQQQTQ--NQ-FIKSLSPP----------------------G
8961_Tthe IGGQPGTNQQSQISHSKIKSSQNL--NQYFYKSQTPP----------------------N
WNK_Spur -----AIGMDK--DQEPARK--EE--KK-GRFTVAPAPCTVGDAV---------------
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ---------------TA-------------------------------------------
Wnk3_Hsap NRC---------------KAMSGS-----FQRGRF----------Q--VITIPQQQSAKM
C46C2.1_Cele DTL---------------KGLAEALGKVIHADGRE----------T--TPMPPDHP----
CG7177_Dmel -----------------TSTGVEE-----PAQGQL----------KIDLQVAGPGGQVQT
Wnk1_Mmus TRLQK---DGTEGHVTATSSGAGV-----VKMGRF----------Q--VSVTMDDAQKER
Wnk2_Mmus ---LAQREQGASSPMTAESSSSNT-----LGCDSDAGQVASDSSTA--PSVPQDASGSS-
Wnk3_Mmus SRC---------------KAMSGS-----FQRGRF----------Q--VITVPQQQPVKM
Wnk4_Mmus ---------------TA-------------------------------------------
Wnk1_Hsap TQPQKGVSQVKEGPVLATSSGAGV-----FKMGRF----------Q--VSVAADGAQKEG
Wnk2_Hsap -----VMEQGTSSSMTAESSPRSM-----LGYDRDGRQVASDSHVV--PSVPQDVPAFV-
17822_Tthe IQSRKETDQGKQKNLMIS-RPPSS-----GQQTRV------------QLTLNEQDVQQQI
8961_Tthe ------------------------------------------------------------
WNK_Spur ------------------------------------------------------------
AqueK219_Aque ---------------TSVSSSS--L----------GQQVYSLASVS--GGVAQSSASYA-
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -----------------------EVES---EASPPPARPL--------------------
Wnk3_Hsap TSFGIEHISV-------FS-ETNHSSEEAF--IKTAKSQLVEI-EPA-TQ---NP--KTS
C46C2.1_Cele ------------------------------DLTDASTQ----------------------
CG7177_Dmel NNSVQNG------------------SV-----VNTPTEVISSP-IQNVPLAINGIQLMYQ
Wnk1_Mmus KNRSEDTKSV------HFESSTSESSV---LSSSSPESTLVKP-EPN-GISISGI--SLD
Wnk2_Mmus -------VPT------HMDPKDQ--------NSSVPREALAAP-MQS-GPGSF-T-----
Wnk3_Mmus MSFGKDHRPP-------FNKTTVQSSEQALTFAEAAVSQLIEV-EPA-MP---TH--KAS
Wnk4_Mmus -----------------------ETEN---EASRNPAQPL--------------------
Wnk1_Hsap KNKSEDAKSV------HFESSTSESSV---LSSSSPESTLVKP-EPN-GITIPGI--SSD
Wnk2_Hsap -------RPA------RVEPTDR--------DGGEAGESSAEP-PPS-DMGTVGG-----
17822_Tthe QNQYTQQNTMISPTYSQYNQSNSKRTS---DNFYAPQETVQSS-QQQ-------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ------------------------------------KSDLVKSGETA-TQD---V--KDV
AqueK219_Aque -------SPN------ETLPQ---------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ---------------------ASDGSV---SSSLNPSL----------------------
WNK_d_Smoe ---------------------CQ-------------GT----------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -PGE----------ARLAP----ISEEGKPQLV-GRFQVTSSK-EPAEP-----------
Wnk3_Hsap FSYE----------KLQALQETCKENKGVPKQ-GDNFLSFSAAC-ETDV-----------
C46C2.1_Cele -------------------------QLISPSNP-DVLTTMSSAVEGSAS-----------
CG7177_Dmel QPQQ----------IHQLPGGTSTTTSGAGTQC---IVVPQVV-NQN-------------
Wnk1_Mmus VPDS----------THKAPTPEAKSDAGQPTKV-GRFQVTTTA-NKVGR-----------
Wnk2_Mmus ---V----------G-SPAQLRGARDSGSPHKRPGQQDNSSPA-KTVGR-----------
Wnk3_Mmus VSSR----------KLRTLYETFKEDKGDPEQ-GD-IVSYSTAC-ETSV-----------
Wnk4_Mmus -LGD----------ARLAP----ISEEGKPQLV-GRFQVTSSK-EPAEP-----------
Wnk1_Hsap VPES----------AHKTTASEAKSDTGQPTKV-GRFQVTTTA-NKVGR-----------
Wnk2_Hsap ---Q----------A-SHPQTLGARALGSPRKRPEQQDVSSPA-KTVGR-----------
17822_Tthe -----------------------------------------------------QSLSNVI
8961_Tthe ------------------------------------------------------------
WNK_Spur VSDLVSQTEKNIDKEGADVAETAKPSAGSPVKL-SRFQVNKVS-DKTSVVEGKTSAEQSV
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ---LP--------------------LQP-----------------TSP-TLSG--S-PK-
Wnk3_Hsap ---SS--------------------VT-PEKEFEETSATGSSMQSGSE-LLLK-------
C46C2.1_Cele ---ST--------------------MIEDIDAS--TSAVDASMMNSMP-PGAQNSTDQI-
CG7177_Dmel -----------------------------------------GTHVQQPSNLQP--Q-QQ-
Wnk1_Mmus ---FS--------------------VSRTEDKV--TELKKEG-PVTSP-PFRD--S-EQ-
Wnk2_Mmus ---FS--------------------VVSTQDEW--TLASPHSLRYSAP-PDVY--LDEI-
Wnk3_Mmus ---SS--------------------VA-TEKNV--TSTTEVSVQSGSE-PLDK-------
Wnk4_Mmus ----P--------------------LQP-----------------ASP-TLSR--S-LK-
Wnk1_Hsap ---FS--------------------VSKTEDKI--TDTKKEG-PVASP-PFMD--L-EQ-
Wnk2_Hsap ---FS--------------------VVSTQDEW--TLASPHSLRYSAP-PDVY--LDEA-
17822_Tthe PSVATNQTNQQQQNQKLSQTPQ-QNLQSKQEEL--SAEQLNQQFY---------------
8961_Tthe ------------------------------------------------------------
WNK_Spur PETAS--------------------IETNKDDQ--TDIEKQP-EAEQP-PLP--------
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------EYPELVS-----------------------------------
WNK_a_Smoe ---SAVEEPPEQDPASFNKLVELRRSDS-------------SQDH-------------AY
WNK_d_Smoe ---FCLDVKTEQTPTNLLKIVEHQN-----------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------KRPEHAG-----------------------------------
WNK_b-1_Smoe ------------------KRPEHAS-----------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------PSTPQ-L-----------------------------------------TSESSD
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------PAAMT-LSMDQECAQSMTSSITRNTTGTKLATFENLETALSSTLGTH-IRQ-PN
CG7177_Dmel ------SVHPN-M-------------------------------------TQQPQQTPLN
Wnk1_Mmus ------TVIPA-V-------------------------------------IPK-KEKPEL
Wnk2_Mmus ------PSSPE-VKLAVRRVQ----------------------TA--SSIEVG-VEE-PA
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------LPSPP-L-----------------------------------------TSESSD
Wnk1_Hsap ------AVLPA-V-------------------------------------IPK-KEKPEL
Wnk2_Hsap ------PSSPD-VKLAVRRAQ----------------------TA--SSIEVG-VGE-PV
17822_Tthe -QSLLSPNSQQVIKFQLQEQSN---------------------NA--PTPMVN-KQQ-LQ
8961_Tthe ------------------------------------------------------------
WNK_Spur ---------------------SATASLAI----------------------KE-ADREPS
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe SW----------EGIAVEREQT--------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap TEDSAGGGPE--------TREALAE------------S---DRAAEGLGAGVEEEGDDG-
Wnk3_Hsap -----------------------EREI-LTAGKQP-SS-DSEFSASLAGSGKSVAKTGP-
C46C2.1_Cele APS------------------------------------------------SRDETTAP-
CG7177_Dmel GHPSMVNT------------------------------LQQQP-----------------
Wnk1_Mmus AEPSHLNGPS---------------------------S---DLEAAFLSRGTEDGSGSP-
Wnk2_Mmus SSDSGDERPR--------RRSQVQKQS-SLPGTGGVASDFVKKATAFLHRSSRAGSLGP-
Wnk3_Mmus -----------------------EKNE-STPGKQT-C--TNEFSATLAGNRKSVTKTRP-
Wnk4_Mmus TEDSAAGGPE--------TREALAE------------S---DRAAEGLGVAVDDEKDEG-
Wnk1_Hsap SEPSHLNGPS---------------------------S---DPEAAFLSRDVDDGSGSP-
Wnk2_Hsap SSDSGDEGPR--------ARPPVQKQA-SLPVSGSVAGDFVKKATAFLQRPSRAGSLGP-
17822_Tthe NQQLQQQQTQ--------QQSQQQQQQ-QQNYQSVI------------------------
8961_Tthe ASSNATQTLN--------QNSQGYNQA-HIPITPQH------------------------
WNK_Spur PHPQQGNEPAVDISVGPAIKP--ERKS-SLIG------SERDTPDSIASDGSSLPSFPP-
AqueK219_Aque ---SDDETDG--------ERQQLLREITRIEEEEKRLKKDKERYQAHLRRGSAITHEYTN
WNK_e_Smoe ---------------------SS-------------------------------------
WNK_a_Smoe ---------------------LVVE-----------------------------------
WNK_d_Smoe ---------------------VDS--------D---------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ---------------------AVPE-------E---------------------------
WNK_b-1_Smoe ---------------------AVPE-----------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap KE----PQ-V--------GGSPQPLSH-------PSPVWM-N-------YSYSSLCLSSE
Wnk3_Hsap ESNQCLPHHE--------EQA-YA----------QTQSSL-F-------YSPSS-PM-SS
C46C2.1_Cele MT----PSFTNERIGGGGGGGA-TSF----------SIGT-P-------PSHSPFPVSEC
CG7177_Dmel ------------------PQQSLPMQ----------------------------------
Wnk1_Mmus HS----PPHL--------CSKSLPVQN-------LSQSLS-N-------SFNSS-YM-SS
Wnk2_Mmus ET----PSRA--------GVK-VPTI----------SITS-F-------HSQSS-YI-SS
Wnk3_Mmus EGDQYLPLRE--------EQA-YA----------QTQNSL-F-------YSPSS-PM-SS
Wnk4_Mmus KE----PL-L--------GGSSPILSH-------PSPVWM-N-------YSYSSLCLSSE
Wnk1_Hsap HS----PHQL--------SSKSLPSQN-------LSQSLS-N-------SFNSS-YM-SS
Wnk2_Hsap ET----PSRV--------GMK-VPTI----------SVTS-F-------HSQSS-YI-SS
17822_Tthe ------------------------AQN-------NQQSQV-NSIQPQVIYSNQQ-QQ-NS
8961_Tthe ------------------------SKD----------------------HAQQN-YI-KS
WNK_Spur EG----PTLQ--------QSAGLPGQPFGPGQGVFAQPESQS-------TPPLS-DV-GS
AqueK219_Aque VM----PKTS--------AVT-YPTHH-------VTSTSS-A-------MLSSA-SL-GP
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ---------------------------------------------SSSC----G--G-VT
WNK_d_Smoe ---------------------------------------------GAGC---------NE
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ---------------------------------------------GSSC---------EE
WNK_b-1_Smoe ---------------------------------------------GSSC---------EE
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -------------------------------------------------ESESS-G----
Wnk3_Hsap -------------------------------------------------DDESE-I----
C46C2.1_Cele ---------------------------------------------DYDLKGQMD-L----
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus -------------------------------------------------DNESD-I----
Wnk2_Mmus -------------------------------------------------DNDSE-F----
Wnk3_Mmus -------------------------------------------------DNESE-I----
Wnk4_Mmus -------------------------------------------------ESESS-G----
Wnk1_Hsap -------------------------------------------------DNESD-I----
Wnk2_Hsap -------------------------------------------------DNDSE-L----
17822_Tthe -------------------------------------------------NNLN---AQ--
8961_Tthe -------------------------------------------------ET------P--
WNK_Spur -------------------------------------------------ASPGP-I-ANA
AqueK219_Aque -------------------------------------------------KDERE-Q----
WNK_e_Smoe ---------TSKQDMVAQW------------------INSTSGTF--H-EGLKHGEVV--
WNK_a_Smoe -------------------------------------------------DLYKA-GEE--
WNK_d_Smoe VLVTIKSSGCPEQQMVVETSEDAVSGPEGSSDIAVAAVAAATTTTVAAVTTSSA-E----
WNK_c_Smoe -------------------------IKEE-------------------------------
WNK_b-2_Smoe -------------------------------------------------EGSSA-G----
WNK_b-1_Smoe -------------------------------------------------EGSSA-G----
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap -------EDEEFWAELQSLRQKH----LSEVETLQTLQKK--------------------
Wnk3_Hsap -------EDEDLKVELQRLREKH----IQEVVNLQTQQNK--------------------
C46C2.1_Cele -------ESED--PEVIQMIVRH----RMEQHKLLEKQRV--------------------
CG7177_Dmel ---TIQSQQQQ-HNQMPIISQQQ----QQQIL-MQQQQQQGSQQGSQQFNLPGTQQTHPQ
Wnk1_Mmus -------EDEDLRLELRRLREKH----LKEIQDLQSRQKH--------------------
Wnk2_Mmus -------EDADIKKELRSLREKH----LKEISELQSQQKQ--------------------
Wnk3_Mmus -------EDEDLKVELQRLREKH----IQEVVSLQTQQNK--------------------
Wnk4_Mmus -------EDEEFWAELQNLRQKH----LSEVEALQTLQKK--------------------
Wnk1_Hsap -------EDEDLKLELRRLRDKH----LKEIQDLQSRQKH--------------------
Wnk2_Hsap -------EDADIKKELQSLREKH----LKEISELQSQQKQ--------------------
17822_Tthe -------QQQQQQLQQQQLQQQQ----QQQL--LQQQQQQ--------------------
8961_Tthe -------EICQLQKPLTKLTKKQICMQRMSM--INSNSDL--------------------
WNK_Spur DLGQVQPSQAEAARELQELLKRQ----DEERAKILHRHRS--------------------
AqueK219_Aque -------QQQQQQQQQQQQQQQS----LQQQLHYQQQQQ---------------------
WNK_e_Smoe -------NPEQREQQHQVLASEE----QQQ-----EQQQE--------------------
WNK_a_Smoe -------DGEEMAHEMVLLMLKQ----EEEIKELQKRHEQ--------------------
WNK_d_Smoe -------QDESIARELKLLALRQ----EQELRELQRKHES--------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe -------IDDPLEWEMAVLAHKQ----EQELRQLRRQHEQ--------------------
WNK_b-1_Smoe -------IDDPLEWEMAVLAHKQ----EQELRQLRRQHEQ--------------------
GK075_Glam -----------------NVGLYR-----EELL-VR-------------------------
Wnk4_Hsap --EIEDLYSRLGKQPP--------------------------------------------
Wnk3_Hsap --ELQELYERLRSIKD--------------------------------------------
C46C2.1_Cele --EIERLRSKIRVP-RA-------------------------------------------
CG7177_Dmel HQFIQSQPNQLHSLP-P-------------------------------------------
Wnk1_Mmus --EIESLYTKLGKVPP--------------------------------------------
Wnk2_Mmus --EIEALYRRLGKPLPP-------------------------------------------
Wnk3_Mmus --ELQELYERLRATKD--------------------------------------------
Wnk4_Mmus --EIEDLYSRLGKQPP--------------------------------------------
Wnk1_Hsap --EIESLYTKLGKVPP--------------------------------------------
Wnk2_Hsap --EIEALYRRLGKPLPP-------------------------------------------
17822_Tthe --QLQQ--SQQQQQ----------------------------------------------
8961_Tthe --SCQE--IGQH------------------------------------------------
WNK_Spur --EMQEFIAHYPQTTPP-------------------------------------------
AqueK219_Aque -----QLHQHLN------------------------------------------------
WNK_e_Smoe --QLLKAE---REDDGI-------------------------------------------
WNK_a_Smoe --ALFM------------------------------------------------------
WNK_d_Smoe --ALLEIRNRCRCKRSSSLSSPQSSPHNQNMDSLSRLLDTDFDLQQLVASQAVDTAAQEA
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe --AVLELRDRYKQKPG--------------------------------------------
WNK_b-1_Smoe --AVLELRDRYKQKPG--------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus ------------------------------------------------------------
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------------------------------------------------------------
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ------------------------------------------------------------
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe -------NTSVTDMHTSSVGDSVSEATVSEVSGAKLEDGF----------DNTSVVGGPR
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe LPFDCDAGETSTAYRISTAGTSSSP-STSLSAVCKPDEGFCFFDQERAVEDHHRPPSSPS
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus ------------------------------------------------------------
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------------------------------------------------------------
Wnk2_Hsap ------------------------------------------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur ------------------------------------------------------------
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ---------------------------------------------------ERECVPGEL
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe SASCSNDCFADLVDIAKATSLAPELERTLKPAGTWPECSFLSQQDATGRKENGLCEPGAL
WNK_c_Smoe ----------------------------------------------------PSCRP---
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap --------------------------PGIV---------A--------------------
Wnk3_Hsap --------------------------SKTQ---STE---I--------------------
C46C2.1_Cele ---------------------------TSV---------N--------------------
CG7177_Dmel --------------------------QVVS---------M--------------------
Wnk1_Mmus --------------------------AVII---------P--------------------
Wnk2_Mmus --------------------------NVGF---------F--------------------
Wnk3_Mmus --------------------------NKAQ---SSE---V--------------------
Wnk4_Mmus --------------------------PGIV---------A--------------------
Wnk1_Hsap --------------------------AVII---------P--------------------
Wnk2_Hsap --------------------------NVGF---------F--------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur --------------------------QS--------------------------------
AqueK219_Aque -----------------------------Y---------Y--------------------
WNK_e_Smoe ----------------------CE----ISVNRMDCAVVEAATPQ---------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe RYETLFDGSERFVDATCSERPSSEMVGEFSGR----EAVEPGKQQQGSLEQRQALRIGGG
WNK_c_Smoe --------------------------GRIQI-----------------------------
WNK_b-2_Smoe --------------------------MRFCGR----PSLE--------------------
WNK_b-1_Smoe --------------------------MRFCGR----PSLE--------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap --PAAMLSSRQR-----------------RLSKGSFP-TSRRNSLQR-------------
Wnk3_Hsap --PLPPASPRRP-----------------RSFKSKLRS--RPQSLTHVDNGIVATGKSCL
C46C2.1_Cele --PEMI--GDDE-----------------ADT----TLTALQSALGN-------------
CG7177_Dmel --AQGNL-----------------------------------------------------
Wnk1_Mmus --PAAPLSGRRR-----------------RPTKSKGSKSSRSSSLGN-------------
Wnk2_Mmus --HTAPPMGRRR-----------------KTSKSKLKAGKLLNPLVQ-------------
Wnk3_Mmus --PLSPASPRRP-----------------RSFKSKLRS--RPQSMTHSDNLVVK------
Wnk4_Mmus --PAAMLSCRQR-----------------RLSKGSFP-TSRRNSLQR-------------
Wnk1_Hsap --PAAPLSGRRR-----------------RPTKSKGSKSSRSSSLGN-------------
Wnk2_Hsap --HTAPPTGRRR-----------------KTSKSKLKAGKLLNPLVR-------------
17822_Tthe -----------I-----------------QQQQQQLN-QN---NILS-------------
8961_Tthe -----------H-----------------HDKKESAN-KS---QFQQ-------------
WNK_Spur -----PLLLYQPNMYSMVPFPMQENFAPPGNFAPQGNF--APQGMWHPSSNLIPYNHFQG
AqueK219_Aque --SIGSSTGQRP-----------------GYHPF--------------------------
WNK_e_Smoe -----------------------------------PG-TG---LYRY-------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ICERD--KASSR-----------------GVERSATT-SS---VLVH-------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe --ELA--MCDDR-----------------GDKRQSFG-SS---EFQF-------------
WNK_b-1_Smoe --ELA--MCDDR-----------------GDKRQSFG-SS---EFQF-------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap --S---------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele --A----SLS--------------LPAS-PPPNT----------ETTKVNT--T------
CG7177_Dmel -------------------------PHQ-LPPMQTMG------AQ--QQMISQQ------
Wnk1_Mmus --K----SPQL---SGNLSGQSGT-SVL-HPQQTLH---PAGNTPETGHNQ--L------
Wnk2_Mmus --Q----LKVVASSTGHLSDSSRGPPTK-DPAHAS-------TPPGTKAVQ--T------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus --S---------------------------------------------------------
Wnk1_Hsap --K----SPQL---SGNLSGQSAA-SVL-HPQQTLH---PPGNIPESGQNQ--L------
Wnk2_Hsap --Q----LKVVASSTGHLADSSRGPPAK-DPAQASVGLTADSTGLSGKAVQ--T------
17822_Tthe --QNIPQT------Q-------------------------------------------NV
8961_Tthe --GILPQL------AQSESRDSSQ-SQAQQQMQQSY---PQPNYSHVNQNQ--MQNQQFT
WNK_Spur VPF----THAPGSAFGGFRQGTTSPPTV--PGMSSMG------VPVQGGMV--T------
AqueK219_Aque ------------------HYYQGGPPLH-PPPHDTRD---------NGSLL--S------
WNK_e_Smoe --SP-K------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe --HKQA------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe --KEVP------------------------------------------------------
WNK_b-1_Smoe --KEVQ------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap -----INEL--E------------------------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel -----QHQLQMQSHMH-QQNVPGMYNQQTGARVAA-------------------------
Wnk1_Mmus -----LQPL--KPSPSSDNLYSAFTSDGAI------------------------------
Wnk2_Mmus -----QQPCSVRASLS-TDICSGLASDGGGARGQGWTVYHPTSE----------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap -----LQPL--KPSPSSDNLYSAFTSDGAI------------------------------
Wnk2_Hsap -----QQPCSVRASLS-SDICSGLASDGGGARGQGWTVYHPTSE----------------
17822_Tthe Q--QII-------EVQ-TQFIQ-SQS----------------------------------
8961_Tthe QQIQTQ-------EIN-QLICNNVTQ----------------------------------
WNK_Spur -----YRPVAGVEMPG-QGAMPGAAPAMTGAQYQVPTTMHPRFSASNEMIPQQTYTNSQG
AqueK219_Aque -----QQNNSSTSNLA-AAAAAGEASRHI-EAGRG-TPYYPTAP----------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap --------------EPP--GP---------GI---------------M------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele --------------VIP--SD---------VL---------------A------------
CG7177_Dmel ---PQNFAGAVP--------------------NHLLQQSPLMASQQPAQP--MQHVMQPI
Wnk1_Mmus ---------SVPSLSAP--GQ---------GT---------------S------------
Wnk2_Mmus -------RGAYKSSSKP--RA---------RF---------------L------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus --------------DLP--GP---------GI---------------M------------
Wnk1_Hsap ---------SVPSLSAP--GQ---------GT---------------S------------
Wnk2_Hsap -------RVTYKSSSKP--RA---------RF---------------L------------
17822_Tthe ----------------P--PPQIGQQK---IQ---------------Q------------
8961_Tthe ----------------HHQNSHHSHSL---II---------------Q------------
WNK_Spur LKRSVSYQ-----SVVP--QP---------N-----TGFQPAFFPNPNQPMGPPNPEAFM
AqueK219_Aque -------IGPHSHIMPQ--EG---------LHLMAPGGMWLPPSDWPQ------------
WNK_e_Smoe -------------------APETDN-----DI---------------L------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe -------------------CSEGEIGLTTLEQ---------------Q------------
WNK_c_Smoe --------------------------KAALEA---------------I------------
WNK_b-2_Smoe -------------------ASKTSCGL---DV---------------Q------------
WNK_b-1_Smoe -------------------ASKTSCGL---DV---------------Q------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus ------------------------------------------------------------
Wnk2_Mmus SGP---------------------------------------------------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------------------------------------------------------------
Wnk2_Hsap SGP---------------------------------------------------------
17822_Tthe ------------------------------------------------------------
8961_Tthe ------------------------------------------------------------
WNK_Spur PRPGAGNAWMSSAGGAMQIMDMKDQQSIQNGINRSPEQLPRGIDNAGVTFPTQQVHPYPS
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------RR----------------
Wnk3_Hsap ------------------------------------------------------------
C46C2.1_Cele ------------------------------------------TR----------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus ------------------------------------------ST----------------
Wnk2_Mmus ---------------------------------VSVSI--SLKR----------------
Wnk3_Mmus ------------------------------------------------------------
Wnk4_Mmus ------------------------------------------RR----------------
Wnk1_Hsap ------------------------------------------ST----------------
Wnk2_Hsap ---------------------------------VSVSIWSALKR----------------
17822_Tthe ------------------------------------------Q-----------------
8961_Tthe ------------------------------------------R-----------------
WNK_Spur HVRTGSGTEKIDFTKRMVPMNSEATEAVTSKGYQA--------QTDLGQVERRLEEARPG
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe ------------------------------------------KK----------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------RK----------------
WNK_c_Smoe ------------------------------------------RR----------------
WNK_b-2_Smoe ------------------------------------------R-----------------
WNK_b-1_Smoe ------------------------------------------R-----------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap --------------------------------------------N-----SLS------G
Wnk3_Hsap --------------------------------------------N-----PLCV------
C46C2.1_Cele --------------------------------------------M-----TMS------Q
CG7177_Dmel -------------------------------------------FN-----ATS------G
Wnk1_Mmus --------------------------------------------N-----TVG------G
Wnk2_Mmus --------------------------------------------L-----CLGKEHSSRS
Wnk3_Mmus --------------------------------------------D-----ALGV------
Wnk4_Mmus --------------------------------------------N-----SLS------G
Wnk1_Hsap --------------------------------------------N-----TVG------A
Wnk2_Hsap --------------------------------------------L-----CLGKEHSSRS
17822_Tthe -----------------------------------------------QFTQNER-----V
8961_Tthe -----------------------------------------------SQPNQQ------T
WNK_Spur GLSQPNYQSENTELHGQIDNRVAVDHPTTDPRPADNNTDVIPTDQ-----TVA------A
AqueK219_Aque ------------------------------------------------------------
WNK_e_Smoe --------------------------------------------EK-LQRSIA------E
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe --------------------------------------------EQLLQKSIA------E
WNK_c_Smoe --------------------------------------------EFLSG-----------
WNK_b-2_Smoe -----------------------------------------------RQKSMS------D
WNK_b-1_Smoe -----------------------------------------------RQKSMS------D
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap S--S-------------TGSQEQ----RASKGVT--------------------------
Wnk3_Hsap --ES-------------NAASCQ--QSPASKKGMFTDDLHKLVDDWTKEAVGNS---LIK
C46C2.1_Cele S--S-------------TKSSNVS------------------------------------
CG7177_Dmel EVT------EEPVSL----AATHPHLLPSDIQSDIKHNLDSLVNQLCNTRLGTN---QHQ
Wnk1_Mmus TVSS-------------QAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLS---GRR
Wnk2_Mmus STSSLAP-GPEPGPQPTLHVQAQ-VNNSNNKKGTFTDDLHKLVDEWTTKTVGAA---QVK
Wnk3_Mmus --ES-------------NTVSCQ--QSPASKKGMFTDDLHKLVDDWTRETVGHF---PSK
Wnk4_Mmus S--S-------------TGSQEQ----RASKGVT--------------------------
Wnk1_Hsap TVNS-------------QAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLS---GRR
Wnk2_Hsap STSSLAP-GPEPGPQPALHVQAQ-VNNSNNKKGTFTDDLHKLVDEWTSKTVGAA---QLK
17822_Tthe V--Q-------------QQQ------ATAQVQQKLIQNNQQLIQ-NSQA-QQLT----QQ
8961_Tthe I--S-------------LNQNM---SIDNSQKGYLINNNQETNQ-ALQNICNLS----QQ
WNK_Spur QLQT-----------PA--SQQQQQQQAGKRKGTFADDKFKNLADLSKPTAARPALDERK
AqueK219_Aque -----YMHP------------HVPPAHFSSTNQAMMQGLHHSITPH--------------
WNK_e_Smoe L--E-------------ARTLE---GLS-KKNGYF-------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe L--E-------------AKTLE---GLHHSRNGYLVSSKKA-------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe M--D-------------VKKSL---ALEA-------------------------------
WNK_b-1_Smoe M--D-------------VKKSL---ALEA-------------------------------
GK075_Glam ------------------------------------------------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ---------------PSLNQ---LKQSQHKLETEN-W----------NKVS---------
C46C2.1_Cele ------------------------------------------------------------
CG7177_Dmel ---------------R-LLL---LRQRQLIEEDEL-RLKHYVEYEKFQKA----------
Wnk1_Mmus ---------------GSKGH---M-------NYE-----------GPGMAR---------
Wnk2_Mmus ---------------PTLNQ---LKQTQKLHDMEA-S----------GDAR---------
Wnk3_Mmus ---------------PSLNQ---LKQSQQKSEAEN-W----------NKSC---------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ---------------GSKGH---M-------NYE-----------GPGMAR---------
Wnk2_Hsap ---------------PTLNQ---LKQTQKLQDMEA-Q----AGWAAPGEAR---------
17822_Tthe ASNQQQQQQQN-QQTLSINQQNLQQQQQIQQQQLNNN----------NNNINMQQQPQQQ
8961_Tthe SSQSAQNDQSPMNQFLSFNP---IQNKQVNQEAQN-Q----------NNNSASRL-----
WNK_Spur ---------------VSLND---LKRAQQQQDLH--------------------------
AqueK219_Aque -----------------------------------------ITHPPPPLSS---------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe AS----------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam -----------------LQQ---FLDENM------------IDKSVVDPA----------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap -------------------------ENTPSTMGYTSTWISSLSQIRGAVPTSLPQ-----
C46C2.1_Cele --------------------------------------VSSRHRDNQSAPPRHHH-----
CG7177_Dmel ------------------------------------LRQSISTNV----PANAAY-----
Wnk1_Mmus ------------------------KFSAPG---Q--LCVPMTSNLGGSTPISAAS-----
Wnk2_Mmus ------------------------ATSVP---------------------RAAVG-----
Wnk3_Mmus -------------------------ESTPSTMGYTSNWISSLSQIRGAAPTSLPQ-----
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ------------------------KFSAPG---Q--LCISMTSNLGGSAPISAAS-----
Wnk2_Hsap ------------------------AMTAP---------------------RAGVG-----
17822_Tthe QQTMLGQNTQVTNVNQQQQYQLQNQVQQQMTNQ--TNVQTNNANIQRSSPIKIEDEIKKI
8961_Tthe -------------------------------------------NLQIIENTN--------
WNK_Spur ------------------------------------------------------------
AqueK219_Aque ------------------------------------------------------H-----
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------LDK---------------------
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap ----------------------------GLSLPSFPG---PLSSYGMPHVC-------QY
C46C2.1_Cele ----------------------------HQPHPPHH---PHLQNHYHP--P-------QN
CG7177_Dmel ----------------------------YSA---AAA---QLPTN---LAAPAAPS----
Wnk1_Mmus ----------------------------ATSLGHFTKSMCPPQQYGFP------------
Wnk2_Mmus ----------------------------ASCLAPAPG---PLSTTATPGATPALPVP---
Wnk3_Mmus ----------------------------GLPLPSFHG---PLASYGMPHVC-------QY
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ----------------------------ATSLGHFTKSMCPPQQYGFP------------
Wnk2_Hsap ----------------------------MPRLPPAPG---PLSTTVIPGAAPTLSVPTPD
17822_Tthe ILEIKLKLQRPQAVKIDRVNHDKVKDENEVRLLQRSLKLCSPQEQILENG---------H
8961_Tthe ------------------------------------------------------------
WNK_Spur ------------------------------------------------------------
AqueK219_Aque ----------------------------LPMQQTYPKSQQAQ----------------QE
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------------------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------------------------------
WNK_b-1_Smoe ------------------------------------------------------------
GK075_Glam ------------------------------------E---DAPKV---ISSDSLPAP--E
Wnk4_Hsap ------------------------------------------------------------
Wnk3_Hsap NAVAGAGYPVQWVGISGTTQQS---VVIPAQSGGPFQPG---------------------
C46C2.1_Cele HTSAT-----------APCPS----------AMVQLQAVS--------------------
CG7177_Dmel ------------------------------------------------------------
Wnk1_Mmus ----PAPFGTQWSGTGGPAPQ----------PLGQFQPVG--------------------
Wnk2_Mmus ------------------------------------------------------------
Wnk3_Mmus NAVGAAGYPVQWVGISGPAQQS---VVLPTQSGGLFQPG---------------------
Wnk4_Mmus ------------------------------------------------------------
Wnk1_Hsap ----ATPFGAQWSGTGGPAPQ----------PLGQFQPVG--------------------
Wnk2_Hsap GALGTARRNQVWFGLRVPPTAC---CGHSTQPRGGQRV-G--------------------
17822_Tthe FACNGAIENDLWKSISNELENQ---L-------AQIENKANLQQQKDQNKKKLIKEIQSQ
8961_Tthe ----------------TP----------------QFSPVPSKQ---------------NP
WNK_Spur ------------------------------------------------------------
AqueK219_Aque VQTYQQPQQLQQEGTLNPVVV----------PAGMTSPTR--------------------
WNK_e_Smoe ------------------------------------------------------------
WNK_a_Smoe ------------------------------------------------------------
WNK_d_Smoe ------------------------------------VG----------------------
WNK_c_Smoe ------------------------------------------------------------
WNK_b-2_Smoe ------------------------------------MP----------------------
WNK_b-1_Smoe ------------------------------------MP----------------------
GK075_Glam A--------------------KVDPLGDNQN-VDEQF-----------------------
Wnk4_Hsap ----------------------FAGDVGRM
Wnk3_Hsap ---MNMQAFPTSSV----QN-PATIPPGPK
C46C2.1_Cele --NNNVN-----PLHQ-PPHPVSSQIPPQA
CG7177_Dmel -----------------SSN-PTSTSSANT
Wnk1_Mmus --TASLQNFNISNLQKSISNP-PGSNLRTT
Wnk2_Mmus -------------------IP-DPESEKPD
Wnk3_Mmus ---MNLQSFPAPPV----QN-PASIPPGPK
Wnk4_Mmus ----------------------FAGDIGRM
Wnk1_Hsap --TASLQNFNISNLQKSISNP-PGSNLRTT
Wnk2_Hsap ---SKT------------ASF-AASDPVRS
17822_Tthe QSKETMNNFE----SKMFSD-FSLTNNDLN
8961_Tthe ------HIPQ----SLNNDC-NLGTQGRNI
WNK_Spur -------AS----AARPPSG-TTKADVPKT
AqueK219_Aque --LEGT---------GDQ-DLTGTSVTQKR
WNK_e_Smoe ---------------------AGLVKKAGV
WNK_a_Smoe ------------------------VRNKSI
WNK_d_Smoe ----------------I-NQ-QQQQQQQQP
WNK_c_Smoe -------------------K-KENEAETSG
WNK_b-2_Smoe ----------------RPEH-KGGHSLEVV
WNK_b-1_Smoe ----------------IPEH-KGGHSLEVV
GK075_Glam --TCAMQ-----E--LNGYL-MIHTDIIPE