Protein (view, download) , Domain (view, download)
Wnk4_Hsap       MLASPATETTV--LMSQTEADLALRP-PPPLGT---AGQPR-----L------GPP----
Wnk3_Hsap       MATDSGDPAST--EDSEKPDGISFEN-RVPQVAATLTVEAR-----LK------------
C46C2.1_Cele    MTVICNRCRNISCRMSITNG--G-RP-PAPPSSVSSTTAST-----TG---NFGTR----
CG7177_Dmel     MVLPPAPRN-----------------------LKGENTSIS-----SEEQTVQGANIQKS
Wnk1_Mmus       MSDGAAEKQS------GTPGF--LTP-PAPVPKNGSSSDSS-----VGE--KLGAT----
Wnk2_Mmus       MDGDGGRRD-A--PGALMEAG------------RGT-GSA--------------------
Wnk3_Mmus       MATDSGEPAST--EDSEKPDGVSFEN-RAARAVAPLTVEAR-----IK------------
Wnk4_Mmus       MLAPRNTETGV--PMSQTEADLALRP-SPALTS---TGPTR-----L------GPP----
Wnk1_Hsap       MSGGAAEKQS------STPGSLFLSP-PAPAPKNGSSSDSS-----VGE--KLGAA----
Wnk2_Hsap       MDGDGGRRD-V--PGTLMEPG------------RGA-GPA--------------------
17822_Tthe      MMILKNRRIK--------------------------------------------------
8961_Tthe       SDYS--------------------------------------------------------
WNK_Spur        MSKSESHNSGS--SLSNGVASLEERDTDVPLKSHSSESVTK-----QGS--K-G-K----
AqueK219_Aque   MTTSTQGQAVI--PEEPT-TNNHLNE-AQPISHQSSSSLLSKGLLVVGD--KIFPG----
WNK_e_Smoe      MCCVMEVES---------------------------------------------------
WNK_a_Smoe      MPASKP------------------------------------------------------
WNK_d_Smoe      MTDKKPED-------HP-------------------------------------------
WNK_c_Smoe      MTDKKPED-------HP-------------------------------------------
WNK_b-2_Smoe    MRTGDGCQAEA--QLHQ-------------------------------------------
WNK_b-1_Smoe    MRTGDGCQAEA--QLHQ-------------------------------------------
GK075_Glam      MEIVAPLS------------------------VF------------------AGT-----


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    -RR-LVNRIKKVDE--------------------------------------LHPAQE--
CG7177_Dmel     GHRSFNRSASSRQKPNPTSKLKDTLNRKPTCKQGTLSAHTSTSSTTSIQSSPIEPASSLP
Wnk1_Mmus       -V-------------------------------------------------------A--
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       -A-------------------------------------------------------A--
Wnk2_Hsap       ------------------------------------------------------------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        -S-------------------------------------------------------G--
AqueK219_Aque   -P-------------------------------------------------------A--
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      -----------QNQP---------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------NPTM---------------GSHWLS-----------------------------
CG7177_Dmel     TLNTTPTPPAASKSNLFVRVLRRFSN---NTLPGKTASSPKNVDDVPKVNDNNNGDLGKQ
Wnk1_Mmus       ------DSGV---------------G---RT-----------------------------
Wnk2_Mmus       -------------------------G---MA-----------------------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ------DAVT---------------G---RT-----------------------------
Wnk2_Hsap       -------------------------G---MA-----------------------------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ------DTQT---------------E---EA-----------------------------
AqueK219_Aque   ------DVSS---------------L---AK-----------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------YPE---------------------------------------------------


Wnk4_Hsap       ------------PRRAR-------------------------------------------
Wnk3_Hsap       -----------------------------------------------EKNS---------
C46C2.1_Cele    ----------EQERSRLEA---------------------------VQQDWRR-------
CG7177_Dmel     QSTDVEVLCSQDNQSREQNEDEMDSKIEPADAISNQKAGLTSGKPKKDKSVKGTSQAVVS
Wnk1_Mmus       ----------EEYRRRRHT---------------------------MDKDS---------
Wnk2_Mmus       ----------E---------------------------------------P---------
Wnk3_Mmus       -----------------------------------------------EKYS---------
Wnk4_Mmus       ------------PRRVR-------------------------------------------
Wnk1_Hsap       ----------EEYRRRRHT---------------------------MDKDS---------
Wnk2_Hsap       ----------E---------------------------------------P---------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ----------EAADA---------------------------------------------
AqueK219_Aque   ----------EDEQSGTHNL--------------------------PDVET---------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ---------R-------------FS----------GKAEPRP--RSSRLSRRSSVDLG--
Wnk3_Hsap       ---------T-------------FS----------ASG-ETV--ERKRFFRKSVEMTE--
C46C2.1_Cele    -------TRP-------------MK----------WTSKKRP--DDPTTSSPSTVSISNA
CG7177_Dmel     DTKKMEARKSSSDTVIEPLIKQQAPLHSSKTTPTTLTA-NFV--QNIRFVRKNVEQSG--
Wnk1_Mmus       ---------R-------------GA----------A-ATTTP--TEHRFFRRSVICDS--
Wnk2_Mmus       ---------R-------------AR-------------AARL--GPQRFLRRSVVESD--
Wnk3_Mmus       ---------T-------------FS----------ASG-ENI--ERKRFFRKSVEMTE--
Wnk4_Mmus       ---------R-------------FS----------GKAEPRP--RSSRPSRRSSVDLG--
Wnk1_Hsap       ---------R-------------GA----------A-ATTTT--TEHRFFRRSVICDS--
Wnk2_Hsap       ---------R-------------AK-------------AARP--GPQRFLRRSVVESD--
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ---------------------------------------SHSGVNGESSMGNSVV-ISNR
AqueK219_Aque   ---------M-------------GS-------------SS----------RPNGVIIENG
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      -------------------------------------QE---------------------
WNK_c_Smoe      -------------------------------------QE---------------------
WNK_b-2_Smoe    -------------------------------------CENR---SRSRFL----------
WNK_b-1_Smoe    -------------------------------------CENR---SRSRFL----------
GK075_Glam      -----------------------VE-----------------------------------


Wnk4_Hsap       ---------LLS-SWSLPASP-A-----------------------PDPPDPP-------
Wnk3_Hsap       ---------DDK-VA----------------------------------ESSPKDERIKA
C46C2.1_Cele    LENSTPSLNNVS-SITNSSSP-FSL----SSAATSTASAIIPFTSNVATNHPHLNHH-VS
CG7177_Dmel     ---------RNTNPLQFVELE-TEFPRDY------------------------DDNI-EM
Wnk1_Mmus       ---------NAT-ALELPGLP-LSIPQPSVPA-------VVP---QSAPPEPHREET-LT
Wnk2_Mmus       ---------QEE----PPGLE---------AA-------ETP---SAQPPQPLQRRV-LL
Wnk3_Mmus       ---------DDK-VA----------------------------------ESSRRDER-KA
Wnk4_Mmus       ---------LLS-SWSQPASL-L-----------------------PEPPDPP-------
Wnk1_Hsap       ---------NAT-ALELPGLP-LSLPQPSIPA-------AVP---QSAPPEPHREET-VT
Wnk2_Hsap       ---------QEE----PPGLE---------AA-------EAP---GPQPPQPLQRRV-LL
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        R------------------SPNFSD-----------------TDVNVESFHN--------
AqueK219_Aque   GETNVHFVS---------------------------------SKEEVLPTEPEKQK----
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       -------------------------------------DSAGPGPA--RSPPPS-------
Wnk3_Hsap       AMNI----PR-------------VDKLPSN-VLRGGQ-----------------------
C46C2.1_Cele    RIPQ----AIVTGGTNGSLPPLLISPTSAAAATPLISGKAGPMSP--STGSPINVAATVL
CG7177_Dmel     LSREAEHLEE-------------QFRTPTRS-----------------------------
Wnk1_Mmus       ATVA----SQ-------------VSQQPSAAASPGEQAVVGSATT--TVPSST-------
Wnk2_Mmus       LCKTRRLIAE-------------RARGRPAAPAPAAP-AAPPGSP--SVPSDP-------
Wnk3_Mmus       ATNI----SR-------------VDKVPTN-VLRGGQ-----------------------
Wnk4_Mmus       -------------------------------------DSAG--PT--RSPPSS-------
Wnk1_Hsap       ATAT----SQ-------------VAQQPPAAAAPGEQAVAGPAPS--TVPSST-------
Wnk2_Hsap       LCKTRRLIAE-------------RARGRPAAPAPAAL-VAQPGAP--GAPADA-------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        --------DK-------------VTENSES-AADTKHTVISDESS--TTGYSS--RLDSI
AqueK219_Aque   -------------------------------------QDGGPVGGGVTPPI--QDSQDGV
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ----------------------------------------------------------SK
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    QNAVSSPQHS-----------------------------------------IFDRSRLNK
CG7177_Dmel     ---------NATDATSHHVAGIIDNIITEASRSLTIEKTEDDVPLKSSTKHS--------
Wnk1_Mmus       ----------------------------------------------------------SK
Wnk2_Mmus       ----------------------------------------------------------GP
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ----------------------------------------------------------SK
Wnk1_Hsap       ----------------------------------------------------------SK
Wnk2_Hsap       ----------------------------------------------------------GP
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        G-------D---------------------------------------------KELLKE
AqueK219_Aque   K-------KK-----------------------------------------VLETLEVEE
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       EPPE------GTW-TEGAPVKAA------------------------------------E
Wnk3_Hsap       ------------------EVKY--------------------------------------
C46C2.1_Cele    IPPN------TSLASSSSPSDAA---NNDKPIQQRHS-----ILSNVRTLTQAMVNDGPR
CG7177_Dmel     --S-------GVK---------------------RVGFQVEDK-----------------
Wnk1_Mmus       DRPV------S----QPSLVGS-------------------------------------K
Wnk2_Mmus       ERAG-------TQEPSPDPTTAS---AAAAQV----------------------PDGGPR
Wnk3_Mmus       ------------------EVKY--------------------------------------
Wnk4_Mmus       EPPE------GTW-MGAAPVKAV-------------------------------------
Wnk1_Hsap       DRPV------S----QPSLVGS-------------------------------------K
Wnk2_Hsap       EPVG-------TQEPGPDPIAAA---VETAPA----------------------PDGGPR
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        KVPDTSVHLANSH-PNGTALKSARKDSNMKPERGRIA-------------------SGNG
AqueK219_Aque   HIV-------NTS-PTGRFVKYE---Q---EI-GRGSFKTVYKG----------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------DSARPELPDSAVG------PGSREPLRVP---EAVALER----RREQ-------
Wnk3_Hsap       -----------------EQ--------CSK--STS---EISKDCFK--EKNEK-------
C46C2.1_Cele    -----------TLT--GDD------M--DK--MVS----EEERARK--EQEKREEEEKA-
CG7177_Dmel     --------------------------DDTE--VQSEKQAKS-----FDDITKKAESSEAS
Wnk1_Mmus       ------EEPPPSRS--GSG------SGGA----SA---KEAQEDR----SQQQ-------
Wnk2_Mmus       ------QEEAPAPTQEDA--------GTTE--AKP----EPGRARK--DEPEE-------
Wnk3_Mmus       -----------------EQ--------CSK--ATS---ESSKDCFK--EKTEK-------
Wnk4_Mmus       ------DSACPELTGSSGG------PGSREPPRVP---DAAARER----RREQ-------
Wnk1_Hsap       ------EEPPPARS--GSG------GG------SA---KEPQEER----SQQQ-------
Wnk2_Hsap       ------EEAAATVRKEDE--------GAAE--AKP----EPGRTRR--DEPEE-------
17822_Tthe      -------------------------------------------------SLKKV------
8961_Tthe       -------------------------------------------------DRDE-------
WNK_Spur        KKQKSVVIMAPVKDITENGHIEVHKEEKVEPLQIH---EMHDSERRLLIETEE-------
AqueK219_Aque   ---------LDTE----TG------VAVAW--CEL---LDSQDGI----KKKV-------
WNK_e_Smoe      ---------------------------------------------------GA-------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      -------------------------------------------ARN--ESKSG-------
WNK_c_Smoe      -------------------------------------------ARN--ESKSG-------
WNK_b-2_Smoe    ------------------------------------------ASRM---SSQL-------
WNK_b-1_Smoe    ------------------------------------------ASRM---SSQL-------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       -----------------------------------EEKEDMETQAVA-------------
Wnk3_Hsap       -----------------------------------EMEEEAEMKAVA-------------
C46C2.1_Cele    -----------------------------ARRIDVEDDFDAQEKPID-------------
CG7177_Dmel     AEEAAVTGSSTDASASPLPSTSLVSTTSSATS-ITKSKSDEDDDPVA-------------
Wnk1_Mmus       -----------------------------------DDIEELETKAVG-------------
Wnk2_Mmus       -----------------------------------EEDDEDDLKAVA-------------
Wnk3_Mmus       -----------------------------------EMEEEAEMKAVA-------------
Wnk4_Mmus       -----------------------------------EEKEDTETQAVA-------------
Wnk1_Hsap       -----------------------------------DDIEELETKAVG-------------
Wnk2_Hsap       -----------------------------------EEDDEDDLKAVA-------------
17822_Tthe      -----------------------------------LKEDLFEQELVQYYYWKIFIFKAIV
8961_Tthe       -----------------------------------NEDNDYKDRIAE-------------
WNK_Spur        -----------------------------------AEPEAVEEKAIA-------------
AqueK219_Aque   -----------------------------------LETLEVEEHIVN-------------
WNK_e_Smoe      -----------------------------------NAADADDSEFVE-------------
WNK_a_Smoe      -----------------------------------GAESDTGSEFVE-------------
WNK_d_Smoe      -----------------------------------KEGEDEEAEFVE-------------
WNK_c_Smoe      -----------------------------------KEGEDEEAEFVE-------------
WNK_b-2_Smoe    -----------------------------------DLGSEDEAEFVE-------------
WNK_b-1_Smoe    -----------------------------------DLGSEDEAEFVE-------------
GK075_Glam      -----------------------------SSP-LRNEGVYYNPFSDT-------------


Wnk4_Hsap       -----------------TSPDGRYLKFDI-EIGRGSFKTVYRGLDTDTTVEVAWCELQTR
Wnk3_Hsap       -----------------TSPSGRFLKFDI-ELGRGAFKTVYKGLDTETWVEVAWCELQDR
C46C2.1_Cele    -----------------KSKNGRFLKFDE-ELGRGSFKTVFRGLDTETGVAVAWCELQES
CG7177_Dmel     -----------------MSPCGRFFKYDK-EVGRGSFKTVYRGLDTLTGVPVAWCELLDK
Wnk1_Mmus       -----------------MSNDGRFLKFDI-EIGRGSFKTVYKGLDTETTVEVAWCELQDR
Wnk2_Mmus       -----------------TSLDGRFLKFDI-ELGRGSFKTVYKGLDTETWVEVAWCELQDR
Wnk3_Mmus       -----------------TSPSGRFLKFDI-ELGRGAFKTVYKGLDTETWVEVAWCELQDR
Wnk4_Mmus       -----------------TSPDGRYLKFDI-EIGRGSFKTVYRGLDTDTTVEVAWCELQTR
Wnk1_Hsap       -----------------MSNDGRFLKFDI-EIGRGSFKTVYKGLDTETTVEVAWCELQDR
Wnk2_Hsap       -----------------TSLDGRFLKFDI-ELGRGSFKTVYKGLDTETWVEVAWCELQDR
17822_Tthe      SCHYSFISTKFHQNTNQIFLQIIKIKFNE-ELGFGAYKTVYKGYDNDSGCEIAWNVIKLQ
8961_Tthe       -----------------TSPKGRFIRFNE-ELGFGAYKTVYRAYDNDSGCEVAWNVIKLQ
WNK_Spur        -----------------KSADGRFMKYDV-AVGQGSFKTVFRGLDTETGVAVAWCELQER
AqueK219_Aque   -----------------TSPTGRFVKYEQ-EIGRGSFKTVYKGLDTETGVAVAWCELLEH
WNK_e_Smoe      -----------------VDPTGRYGRYNE-VLGRGAFKTVYKAFDEVDGIEVAWNQVNVQ
WNK_a_Smoe      -----------------IDPTGRYGRYSE-VLGKGAFKAVYRAFDEVDGLEVAWNQVNVQ
WNK_d_Smoe      -----------------RDPTGRYGRYNE-ILGKGAFKTVYRAFDEVDGIEVAWNQVKVE
WNK_c_Smoe      -----------------RDPTGRYGRYNE-ILGKGAFKTVYRAFDEVDGIEVAWNQVKVE
WNK_b-2_Smoe    -----------------VDPTGRYGRYKE-LLGKGAFKTVYKAFDEIDGIEVAWNQVKLH
WNK_b-1_Smoe    -----------------VDPTGRYGRYKE-LLGKGAFKTVYKAFDEIDGIEVAWNQVKLH
GK075_Glam      -----------------LGPSDRYLKYSGDVLGKGAFKTVYRAFDLIAGREVAWNEVVLD
                                         ::.   :* *::*:*::. *      :**  :

Wnk4_Hsap       KLS--RAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKT
Wnk3_Hsap       KLT--KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESIL--KGKKCIVLVTELMTSGTLKT
C46C2.1_Cele    KLN--KTERQRFREEAEMLKDLQHPNIVRFYDYWESADLCGKRKYIVLVTELMTSGTLKM
CG7177_Dmel     QVK--KSERTRFREEADMLKKLQHPNIVRFYTYWEFPI--GRKKNIVLVTELMLSGTLKS
Wnk1_Mmus       KLT--KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKT
Wnk2_Mmus       KLT--KLERQRFKEEAEMLKGLQHPNIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKT
Wnk3_Mmus       KLT--KAEQQRFKEEAEMLKGLQHPNIVRFYDSWESTL--KGKKCIVLVTELMTSGTLKT
Wnk4_Mmus       KLS--RAERQRFSEEVEMLKGLQHPNIVRFYDSWKSVL--RGQVCIVLVTELMTSGTLKT
Wnk1_Hsap       KLT--KSERQRFKEEAEMLKGLQHPNIVRFYDSWESTV--KGKKCIVLVTELMTSGTLKT
Wnk2_Hsap       KLT--KLERQRFKEEAEMLKGLQHPNIVRFYDFWESSA--KGKRCIVLVTELMTSGTLKT
17822_Tthe      RLP--Q--------------------------------------------QCLSGGSLK-
8961_Tthe       RLP--LNERKRISEEIQLLKNLHHPNIINFINAWINKS----KNEVIFITECVSGGSLKK
WNK_Spur        KLS--RSERQRFKEEAEMLKGLSHPNIVSFYDYWEEVSP-RGKKHIVLVTELMTSGTLKT
AqueK219_Aque   KFN--KEEQSRFKEEVAILKTLNHPYILRLFDSWEFVRQSDKKRVLVLITELMTSGTLKS
WNK_e_Smoe      DVLGRPEDLERLYSEVHLLRGLKHKNVIKFFTSWVDPR----TKNVNFITEIFTSGTLRQ
WNK_a_Smoe      DLLRSPDDLERLYSEVHLLKTLKHKNIIKFYTSWVDSK----RRNVNFITEIFTSGTLRQ
WNK_d_Smoe      DVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQ
WNK_c_Smoe      DVLQSPEDLERLYSEVHLLKSLKHKNIIKLYNSWVDTK----TKNVNFITEIFTSGTLRQ
WNK_b-2_Smoe    DVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDTK----NNNVNFITEIFTSGNLRQ
WNK_b-1_Smoe    DVLRSPEDLERLYSEVHLLKSLKHKNIIKFYNSWVDTT----SNNVNFITEIFTSGNLRQ
GK075_Glam      TLE--PMASSKLFQEIKALKDVDHENIIKLYDHWFE-----GSNLLIFTTELMPSGCLKK
                 .                                                : . .* *:

Wnk4_Hsap       YLRRFR-EMKPRV-LQRWSRQILRGLHFLHSRVP-PILHRDLKCDNVFITGPTGSVKIGD
Wnk3_Hsap       YLKRFK-VMKPKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
C46C2.1_Cele    YLKRFK-RINIKVVLKSWCRQILKGLSFLHTRNP-PVIHRDLKCDNIFITGTTGSVKIGD
CG7177_Dmel     YLKRFK-KIHPKV-LKSWCRQILKGLNFLHTRQF-PIIHRDLKCDNIFITGTTGSVKIGD
Wnk1_Mmus       YLKRFK-VMKIKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk2_Mmus       YLKRFK-VMKPKV-LRSWCRQILKGLLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk3_Mmus       YLKRFK-VMKPKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk4_Mmus       YLRRFR-EMKPRV-LQRWSRQILRGLHFLHSRVP-PILHRDLKCDNVFITGPSGSVKIGD
Wnk1_Hsap       YLKRFK-VMKIKV-LRSWCRQILKGLQFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
Wnk2_Hsap       YLKRFK-VMKPKV-LRSWCRQILKGLLFLHTRTP-PIIHRDLKCDNIFITGPTGSVKIGD
17822_Tthe      ---KIK-KPRLKI-IKQWCKQILSGLQYLHEQEPHPIIHRDIKCENIFVNTVNNEIRIGD
8961_Tthe       HLKKIK-KPRLKI-IKNWCRQILKGLVYLHEQKPYPIIHRDIKCENVFISTTNNEIRIGD
WNK_Spur        YLKRFK-GVKNRV-LRSWCRQILKGLHFLHTRQP-PIIHRDLKCDNIFITGTSGAVKIGD
AqueK219_Aque   YMRRFK-SIKPRV-IRSWGRQILRGLSFLHTRTP-PIIHRDLKCDNVFINGTTGLVKIGD
WNK_e_Smoe      YRKKHK-NVDMKA-VKNWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNQGEVKIGD
WNK_a_Smoe      YRKKHK-NVDMKA-VKNWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNYGEVKIGD
WNK_d_Smoe      YRKKHK-HVDMRA-VKNWAKQILRGLLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGD
WNK_c_Smoe      YRKKHK-HVDMRA-VKNWAKQILRGLLYLHSHNP-PIIHRDLKCDNIFVNGNQGEVKIGD
WNK_b-2_Smoe    YRRKHK-HVDLKA-VKHWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGD
WNK_b-1_Smoe    YRRKHK-HVDLKA-VKHWARQILRGLLYLHSHDP-PIIHRDLKCDNIFVNGNHGEVKIGD
GK075_Glam      YLKKNPTALTTPV-LKSWALQILEALNYMHTCQP-KIIHRDIKAQNIFINGATGVVKVGD
                   :          :: *  *** .* ::*      ::***:*.:*:*:.   . :::**

Wnk4_Hsap       LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSEC
Wnk3_Hsap       LGLA-TL-MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
C46C2.1_Cele    LGLA-TL-KNKSFAKSVIGTPEFMAPEMYE-EMYDESVDVYAFGMCLLEMVTGEYPYSEC
CG7177_Dmel     LGLA-TL-KNRSHAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMAISEYPYSEC
Wnk1_Mmus       LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk2_Mmus       LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk3_Mmus       LGLA-TL-MRTSFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk4_Mmus       LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDEAVDVYAFGMCMLEMATSEYPYSEC
Wnk1_Hsap       LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EKYDESVDVYAFGMCMLEMATSEYPYSEC
Wnk2_Hsap       LGLA-TL-KRASFAKSVIGTPEFMAPEMYE-EHYDESVDVYAFGMCMLEMATSEYPYSEC
17822_Tthe      LGLA-LT-LKSDFTTSVLGTPEFMAPEIYE-EKYGTAVDIYAFGMCLLEMATLQIPYREC
8961_Tthe       LGLA-VSLKNSSHTKSVIGTPEFMAPEIYE-EKYGTPVDIYSFGMCVLEMATLSTPYKEC
WNK_Spur        LGLA-TL-KKSSFAKSVIGTPEFMAPEMYE-EHYDEAVDVYAFGMCLLEMATSEYPYAEC
AqueK219_Aque   LGLA-TL-KRS-DVKTVIGTPEFMAPEMYD-EVYDESVDVYAFGMCLLEMCTLEYPYQEC
WNK_e_Smoe      LGLA-TILRQAHAAHSVIGTPEFMAPELYE-EDYNELVDIYAFGMCVLELVTFDYPYSEC
WNK_a_Smoe      LGLA-TILRQAHAAHSVIGTPEFMAPELYE-EEYDELVDIYSFGMCVLEMVTFEYPYSEC
WNK_d_Smoe      LGLA-AILRQAHAAHSVIGTPEFMAPELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSEC
WNK_c_Smoe      LGLA-AILRQAHAAHSVIGTPEFMAPELYE-EEYNELVDIYSFGMCLLEMVTFEYPYSEC
WNK_b-2_Smoe    LGLA-GILRQAHGAHSVIGTPEFMAPELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSEC
WNK_b-1_Smoe    LGLA-GILRQAHGAHSVIGTPEFMAPELYE-EDYNELVDIYSFGMCLLEMVTFEYPYSEC
GK075_Glam      LGLCASL-GLQSTAVSCIGTPEFMAPETYSNAHYDEKVDIYAFGMLLLELITRDTPYLEC
                ***.         . : :********* *.   *.  **:*:*** :**:   . ** **

Wnk4_Hsap       QNAAQIYRKVTSGRKPNSFHKV--KIPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREER
Wnk3_Hsap       QNAAQIYRKVTSGIKPASFNKV--TDPEVKEIIEGCIRQNKSERLSIRDLLNHAFFAEDT
C46C2.1_Cele    MNPATIYRKVISGVKPECFSRIPAQYPEIREIIDRCIRVRREERSTVKQLLVDDFFTPED
CG7177_Dmel     KGPAQIYKKVISGIKPAALAKV--EDPNVRDIIERCIELKKEDRPSCNELLESEFFDEDI
Wnk1_Mmus       QNAAQIYRRVTSGVKPASFDKV--AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET
Wnk2_Mmus       QNAAQIYRKVTCGIKPASFEKV--HDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDT
Wnk3_Mmus       QNAAQIYRKVTSGIKPASFNKV--TDPEVKEIIEGCIRQNKSERLSIKDLLNHAFFAEDT
Wnk4_Mmus       QNAAQIYRKVTSGTKPNSFYKV--KMPEVKEIIEGCIRTDKNERFTIQDLLAHAFFREER
Wnk1_Hsap       QNAAQIYRRVTSGVKPASFDKV--AIPEVKEIIEGCIRQNKDERYSIKDLLNHAFFQEET
Wnk2_Hsap       QNAAQIYRKVTCGIKPASFEKV--HDPEIKEIIGECICKNKEERYEIKDLLSHAFFAEDT
17822_Tthe      TSAAQVYKKVSQGLLPNSLQLI--QNDSLKQFILKCIQR-SENRPSAAQLLQDDFFKESE
8961_Tthe       TSAAQVYKKVSQGILPYQIDLI--QNEGLKNLILKCLSH-YKDRPSAEELLNDKFLDMSE
WNK_Spur        SNAAQIYRRVTTGVKPQSFEKV--NDNKIKEIIDGCTKTNNTERYLIQELLKHTFFED-T
AqueK219_Aque   SNPAQIYKKVTSGVMPNSLNKV--NDPMLKEIIVACTKLSKSARYTVEMLLNHEFFAEGD
WNK_e_Smoe      TNAAQIYKKVSSGIKPAALDKV--KDPEVRSFIQKCLAT-ASKRLPARELLKDPFLQCES
WNK_a_Smoe      TNAAQIYKRVTSGKKPAAFEKV--KDPEVRKFIEKCLAA-VSRRLPARELLMDPFLRCDG
WNK_d_Smoe      TNAAQIYKKVTSGKKPAALDRV--KDLEVRAFIEKCLAT-VSKRLPARELLMDPFLQSED
WNK_c_Smoe      TNAAQIYKKVTSGKKPAALDRV--KDLEVRAFIEKCLAT-VSKRLPARELLMDPFLQSED
WNK_b-2_Smoe    MNAAQIYKKVTSGKKPAALNKV--QDPQMRAFVEQCLAK-ACRRLPARELLMDPFLQCHT
WNK_b-1_Smoe    MNAAQIYKKVTSGKKPAALNKV--QDPQMRAFVEQCLAK-ACRRLPARELLMDPFLQCHT
GK075_Glam      ANIVDVLKKVEGNIPPNGLNKV--VHKEMKDLILLCINKDPSARPSARELLSKPFLSNMS
                 . . : ::*  .  *  :  :      :: ::  *       *     **   *:

Wnk4_Hsap       --GVH---VELAEEDDG------------E------------------------------
Wnk3_Hsap       --GLR---VELAEEDDC------------S------------------------------
C46C2.1_Cele    LIGIR---VEIKNRDAD------------LNDL---------------------------
CG7177_Dmel     --GIR---VEPTASEQF-----------LSDPS---------------------------
Wnk1_Mmus       --GVR---VELAEEDDG------------E------------------------------
Wnk2_Mmus       --GVR---VELAEEDHG------------R------------------------------
Wnk3_Mmus       --GLR---VELAEEDDC------------S------------------------------
Wnk4_Mmus       --GVH---VELAEEDDG------------E------------------------------
Wnk1_Hsap       --GVR---VELAEEDDG------------E------------------------------
Wnk2_Hsap       --GVR---VELAEEDHG------------R------------------------------
17822_Tthe      I---DNQPIQLASDR---------------IPQ---------------------------
8961_Tthe       Q-DEDNYPVQLLDAS---------------NAS---------------------------
WNK_Spur        --AFR---VDIVHDDN--------------------------------------------
AqueK219_Aque   ---VK---VEVMTEPTP------------AD-----------------------------
WNK_e_Smoe      D--RDGVADSLPSLNKD---------RVN---DMEEL---------PSRNPYSEFKDDTQ
WNK_a_Smoe      E---RESLE--------CIPVIRKQSRVD---DMEELRSSAVTNHE----SDQGDSDQQR
WNK_d_Smoe      R--EPLDPEQ-SQTDS-------------DQGGLGSYQKGV------------SFREEGK
WNK_c_Smoe      R--EPLELVP-PISRS--------TSRADDMEGLST------------------------
WNK_b-2_Smoe    A--ERGVVHE-PHNSMDELEVILEEN---GDDSLSTIHAGAMAYDLAPRGAHHNHHELTR
WNK_b-1_Smoe    A--ERGVVHE-PHDSMDELEVILEEN---GDDSLSTIHAGAMAYDLAPRGAHHNHHELTR
GK075_Glam      --DTG-K-LTTDAKDHG-----------P-SAQ---------------------------


Wnk4_Hsap       -------------K----------PGLKLWLRMEDA-------------R-RG-GRPRDN
Wnk3_Hsap       -------------N----------SSLALRLWVEDP-------------KKLK-GKHKDN
C46C2.1_Cele    -------------N----------VEIQMQLRVYDE-------------KKRKQYRFKEN
CG7177_Dmel     -------------I----------SIIEFRLRFMDP-------------KKRS-SRHKEN
Wnk1_Mmus       -------------K----------IAIKLWLRIEDI-------------KKLK-GKYKDN
Wnk2_Mmus       -------------K----------STIALRLWVEDP-------------KKLK-GKPKDN
Wnk3_Mmus       -------------N----------SSLALRLWVEDP-------------KKLK-GKHKDN
Wnk4_Mmus       -------------K----------PGLKLWLRMEDA-------------R-RG-GRPRDN
Wnk1_Hsap       -------------K----------IAIKLWLRIEDI-------------KKLK-GKYKDN
Wnk2_Hsap       -------------K----------STIALRLWVEDP-------------KKLK-GKPKDN
17822_Tthe      ------SLGNSNDS---------------------P--------------Q-------TN
8961_Tthe       ------------------------------------------------------------
WNK_Spur        -------------K----------DQIQLQLRVEDP-------------KKRR-ERHRDN
AqueK219_Aque   -------------------------SVMVRLVVPRT-------------SK-E-NKKNEQ
WNK_e_Smoe      KSKDFKVKGKLRQ-----------DNIFLRLRISEQ--------------G-------HV
WNK_a_Smoe      KSIDFKVKGRRRED----------DTIFLRLRIADP-------------EG-------HI
WNK_d_Smoe      RSRDFRVKGKKKDD----------DTIFLRVRIADL-------------EG-------HV
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    RSRDFRVRVRRRND----------DTIFLKLRIADQ-------------EG-------CI
WNK_b-1_Smoe    RSRDFRVRVRRRND----------DTIFLKLRIADQ-------------EG-------CI
GK075_Glam      -------------VSLGTHEQTMQSTGHTAVNAAQTALKLPQQSSLPISSPRG-PQQSH-


Wnk4_Hsap       QAIEFLFQLGRDAAEEVAQEMVALGL-------------------------VCE--ADYQ
Wnk3_Hsap       EAIEFSFNLETDTPEEVAYEMVKSGF-------------------------FHE--SDSK
C46C2.1_Cele    EGLQFAFDIENDSPDEVVQQMIEQQH-------------------------IPD--EDTR
CG7177_Dmel     EAIQFEYNIRHDEYEQIAQEMMKENI-------------------------ISE--DDSR
Wnk1_Mmus       EAIEFSFDLERDVPEDVAQEMVESGY-------------------------VCE--GDHK
Wnk2_Mmus       GAIEFTFDLEKETPDEVAQEMIDSGF-------------------------FHE--SDVK
Wnk3_Mmus       EAIEFSFNLEADTPEEVAYEMVKSGF-------------------------FHE--SDSK
Wnk4_Mmus       QAIEFLFQLGRDAAEEVAQEMVALGL-------------------------VCE--ADYQ
Wnk1_Hsap       EAIEFSFDLERDVPEDVAQEMVESGY-------------------------VCE--GDHK
Wnk2_Hsap       GAIEFTFDLEKETPDEVAQEMIESGF-------------------------FHE--SDVK
17822_Tthe      H-QQQSFQQNQDQHSQVQSSNFKKTS-------------------------DFE--SPIH
8961_Tthe       --TPMNYTLSNSCPLESAQVFQLKGQKNTEASPCTDQNQNNEIQSQEIHSDNLK--DNMF
WNK_Spur        EALQFEIDLNKDEPDQVAKEMVRIGF-------------------------VSE--EDSK
AqueK219_Aque   ESIEFAYNLQTDIPEDIVNDMVKSGI-------------------------LRE--EDKK
WNK_e_Smoe      RNIHFAFDLEADTAFSVASEMVTELD-------------------------LSD--QDVA
WNK_a_Smoe      RNIHFPFDVEGDTALSVASEMVAELD-------------------------LSD--QDVT
WNK_d_Smoe      RNIHFPFSIEGDTAMSVASEMVAELD-------------------------LSD--QDVT
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    RNIHFPFDVEADTALCVASEMVAELD-------------------------LSD--QDVT
WNK_b-1_Smoe    RNIHFPFDVEADTALCVASEMVAELD-------------------------LSD--QDVT
GK075_Glam      ----IPQSL--SKPVCPASMGVSVVN-------------------------VAVPTTAVT


Wnk4_Hsap       PVARAVRE----RVAAIQRK----RE---KLR-KAR----ELEALPP------E------
Wnk3_Hsap       AVAKSIRD----RVTPIKKT----RE---KKP-AG-----CLEERRD------SQCKSM-
C46C2.1_Cele    MITKLIKD----KVDAFRRD----RD---HRL-LEIKRAKEEEERIR-------EEAEIK
CG7177_Dmel     AVARLLKV----QVVSLLKE----RA---QRQ-TQIKL---QNEKSR------LEKLALQ
Wnk1_Mmus       TMAKAIKD----RVSLIKRK----RE---QRQ-LVR----EEQEKRK------QEESSFK
Wnk2_Mmus       IVAKSIRD----RVALIQWR----RE---RIW-PAL----QSQEPKD------SGSPDKA
Wnk3_Mmus       AVAKSIRD----RVTLIKKI----RE---KKP-AG-----CLEERRD------SQCKYV-
Wnk4_Mmus       PVARAVRE----RVAAIQRK----RE---KLR-KAR----ELEVLPP------D------
Wnk1_Hsap       TMAKAIKD----RVSLIKRK----RE---QRQ-LVR----EEQEKKK------QEESSLK
Wnk2_Hsap       IVAKSIRD----RVALIQWR----RE---RIW-PAL----QPKEQQD------VGSPDKA
17822_Tthe      QVSQKQDNNSSSSASKSSHS----KQHRGSNQAS----------------P-AQSQNS-S
8961_Tthe       -IPRKQSNFSDKKTTSLSHK----KK---KNQLTI-----DVTEYDFDEVN-KQQQLALQ
WNK_Spur        AVTKVIRD----RIGTVWKN----RE---KRE-KER----QEKGKLE------EDKDSKA
AqueK219_Aque   NAIRSVRE----LTDPLTDPAKQKRQ---QKP-A-A----TAGATAP------HG-----
WNK_e_Smoe      TIAEMIDA----EILSLVPD----WK---P---GG-----AFDADDEKG---VEDTGPV-
WNK_a_Smoe      TIAEMIDA----EILNLVPD----WK---P---GA-----AFDESGGDGENNYIDGDDM-
WNK_d_Smoe      TIAEMIDA----AIVALVPD----WR---P---GA-----SFEDNGVTE---VDDQAQA-
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    TIADMIDA----EIVLLVPH----WR---P---GA-----SFEEHREDTI--LHDTDDI-
WNK_b-1_Smoe    TIADMIDA----EIVLLVPH----WR---P---GA-----SFEEHREDTT--LHDTDDI-
GK075_Glam      ---------------NSLSH----VL---ASE--TVST---DQSGSI------L------


Wnk4_Hsap       ---PGPPPA---------------TVPMAPG--P---PSVFPPEPEEPEADQH-------
Wnk3_Hsap       -GNVFPQPQ-------------NTTLPLA----P---AQQTGAECEETEVDQH-------
C46C2.1_Cele    E--ELRLRAEAKEKEKERLEKERLEKKAAAAAAANPNPTPIPPTPATPHSSAQ-------
CG7177_Dmel     K--QRE------------------SLP----TN----VDEDEEEEEESEDEEDGVKWNQR
Wnk1_Mmus       Q--QNEQQASVSQAGIQQLSAASTGIPTAPATSA---SVSTQVEPEEPEADQH-------
Wnk2_Mmus       RGLPAPLQV-------------QVTYH----AQS---GQPGQPEPEEPEADQH-------
Wnk3_Mmus       -RNVLPQQQ-------------TATLQPT----P---GPHTAAEYEETEVDQH-------
Wnk4_Mmus       ---SGPPPA---------------TVSLAPG--P---PSAFPPEPEEPEADQH-------
Wnk1_Hsap       Q--QVEQS-SASQTGIKQLPSASTGIPTASTTSA---SVSTQVEPEEPEADQH-------
Wnk2_Hsap       RGPPVPLQV-------------QVTYH----AQA---GQPGPPEPEEPEADQH-------
17822_Tthe      Q---------------------------------------SSEKPAQQNLTQN-------
8961_Tthe       Q---------------------------------------QQEKQIQQDLVQV-------
WNK_Spur        -----DAGTSTTDSGMGFSGLSLTGMSNASEGSTR--LVSSQVQN----SSST-------
AqueK219_Aque   -NP------------------------PVPGNGAAG--------KETGEGLSH-------
WNK_e_Smoe      ------------------------------------------A-----------------
WNK_a_Smoe      ------------------------------------------K-----------------
WNK_d_Smoe      -----------------------------------------REES---------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------D-----------------
WNK_b-1_Smoe    ------------------------------------------D-----------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     LQLRYDLLNTDSETSLALSTNSVEPQQLSTRSNTSIPNSGIQQPVQVPGQVPVSQLISVQ
Wnk1_Mmus       ------------------------------------------------------------
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ------------------------------------------------------------
Wnk2_Hsap       ------------------------------------------------------------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ------------------------------------------------------------
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       -------QPFLFRH-----------ASYSSTTSDCETDGYLSSSGFL--DASDP------
Wnk3_Hsap       -------VRQQLLQRKP-------QQHCSSVTGDNLSEAGAASVIHS--DT--SSQPSVA
C46C2.1_Cele    -------QQPIPPP-----------LSTQTSAE---------------------------
CG7177_Dmel     PQAIPSPAIPMQQK-----------PTV-HYIQPPQLASYQNSNASM--QEMTNNQVISP
Wnk1_Mmus       -------QQLQYQQ-----------PSI-SVLSDGTIDSGQGSSVFT--ESRVSSQQTVS
Wnk2_Mmus       -------LLPPTLP-----------ASVTSLASDSTFDSGQGSTVYS--DSQ-SSQQSMV
Wnk3_Mmus       -------VRQQFLQGKP-------QQQSSSVRGDTSSEPTAGPVLHS--DT--SSHPTVA
Wnk4_Mmus       -------QSFLFRH-----------ASYSSTTSDCETDGYLSSSGFL--DASDP------
Wnk1_Hsap       -------QQLQYQQ-----------PSI-SVLSDGTVDSGQGSSVFT--ESRVSSQQTVS
Wnk2_Hsap       -------LLPPTLP-----------TSATSLASDSTFDSGQGSTVYS--DSQ-SSQQSVM
17822_Tthe      -------QSSIPKHESQNSLSSIGQNQTNSVQSSFHDQDANSKKLLT--TT--DGLTS-K
8961_Tthe       -------NENIFVQVS-NTTSLVH--QSDSLETDSNYKTPQNQRNKSRMNT--FNSQSIS
WNK_Spur        -------QQPISQQ-----------PH-------------------S--QSQIQQQQVPS
AqueK219_Aque   -------QLL----------------------SNETTPTPQEIE-LS--ANRANFQRQLS
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      --------------------------------------------------------PS--
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       YSSNQTMGSQMV---SNI----PQAEVNVPG------QIYSSQQLVGHY----QQVS---
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     TGSQQMQQQQPV---------------------------------------------VAP
Wnk1_Mmus       YGSQHEQAHSTG---------------------------------------------TAP
Wnk2_Mmus       LSSLVDTAPTPA---SCV----CSPPVSEGP------GLTHSLPTLGAF----QQPATVP
Wnk3_Mmus       YSSNQTTSSQVF---SSI----LQAYISVPE------QIHSSYQLLGYGIYLFSFIY---
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       YGSQHEQAHSTG---------------------------------------------TVP
Wnk2_Hsap       LGSLADAAPSPA---QCV----CSPPVSEGP------VLPQSLPSLGAY----QQPTAAP
17822_Tthe      NGQNDSNMEQSI---TQIPSEE--RQVKVNK------Q--QSSE----------------
8961_Tthe       IQNNQSIQINTMTNNTSVVNQSTSNQVELNE------SIQSTSERF--------------
WNK_Spur        HPQQTQQPSSQQ---------------------------------------------SVA
AqueK219_Aque   SA----------------------------------------------------------
WNK_e_Smoe      -------------------------------EAEELNATE--------------------
WNK_a_Smoe      -------------------------------NLG--DATDNVSS----------------
WNK_d_Smoe      -----------------------VAQVSVPEEVESPSAVDATSD----------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    -------------------------------TCE--------------------------
WNK_b-1_Smoe    -------------------------------TCE--------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     TVNHQVMPQQQVNQQQQQPQMMQQIPQQVQ-VQQPQ--------------TVLPPQPHEQ
Wnk1_Mmus       ----------------------GHTVSSIQAQSQPH--------------GVYPPSS-MA
Wnk2_Mmus       ----------------------GLSVGPVPPPARPPLLQQHFPESSMSFTPVLPPPS-TP
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ----------------------GHIPSTVQAQSQPH--------------GVYPPSS-VA
Wnk2_Hsap       ----------------------GLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPS-TP
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ------------------------TPQVQQQQ----------------------------
AqueK219_Aque   --------------------------------------------------------S-DE
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ----------GLQKHS---KLTQPQILP--------------------------------
C46C2.1_Cele    ---------------------------IQQ------------------------------
CG7177_Dmel     QPQQQQQPLQQQLQ----QLMHTNVQAPDLTQ--QQQMAQQQAQQYFQQQQQQPQQAVNM
Wnk1_Mmus       QGQNQGQPSSS-LAGV---LSSQPIQHPQQQ-GIQPTVPSQQAVQY------------SL
Wnk2_Mmus       VPTGPSQPAPPVQQPL---PMAQPPTLPQVL-APQPMGTVQPVPSH------------LP
Wnk3_Mmus       ----------HLQEQP---KLTQSPVLP--------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       QGQSQGQPSSSSLTGV---SSSQPIQHPQQQQGIQQTAPPQQTVQY------------SL
Wnk2_Hsap       MPTGPGQPAPPGQQPP---PLAQPTPLPQVL-APQPVVPLQPVPPH------------LP
17822_Tthe      ----------------------------------------SYYDQA------------IP
8961_Tthe       --------------------------------------NIQKAYQN------------FK
WNK_Spur        --GQPQQPQPPQQQQQPQQVQSQPVMQPPQS-VQQPLPPQVHSQTH------------SQ
AqueK219_Aque   MSSEPSGPKHTTDRTG---PSAQVNN----------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    -----------------S--AQQPSVPVTMIANIPAMS----------------------
CG7177_Dmel     QQAY-AMQ------------------------------QAGQQQQLSQPLQIQQQIL---
Wnk1_Mmus       PQAA-SSS---EGTTAQP--VSQP------------QVSAGTQLPVSQTVATVQGE----
Wnk2_Mmus       PYLA-PTSQVVAPAQLKP--LQMPQPPLQPLAQVPPQM---PQMPVVPPITPLTGLDGLP
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       SQTS-TSS---EATTAQP--VSQPQAP-----QVLPQVSAGKQLPVSQPVPTIQGE----
Wnk2_Hsap       PYLA-PASQVGAPAQLKP--LQMPQAPLQPLAQVPPQM---PPIPVVPPITPLAGIDGLP
17822_Tthe      NGLQ-NTKQYSKDSQT----------------------SQITQIEIKNKSQEVEDKINTP
8961_Tthe       IFKQ-DQSELDTPV------------------------------DLRQISQKEQKITQQT
WNK_Spur        PQLVSQSSQQPSTTAVLPQQDQAQQQPMQPSAQQP-------------PISNVQQQ----
AqueK219_Aque   -----------------------------------------------------TGVGGAG
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      -----DGSH---------------------------------------------------
WNK_d_Smoe      -----DETR---------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    -------PTSAQ-P-------Q--PV--L--------------S-----PT---------
CG7177_Dmel     --QQQQVAVSHQ-Q-------QIMQQ--Q--------------L------AQH-QLQQLQ
Wnk1_Mmus       ----PHIPVSTQ-P-------SVVPV--H--------------S------GAH-FLP---
Wnk2_Mmus       Q-TLTDLPAANV-A-------PVPPPQYF--------------S------PAV-ILP---
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ----PQIPVATQ-P-------SVVPV--H--------------S------GAH-FLP---
Wnk2_Hsap       P-ALPDLPTATV-P-------PVPPPQYF--------------S------PAV-ILP---
17822_Tthe      S-QVQDLDSLNI-K-------ATPQITEK--------------S------NSDQVQN---
8961_Tthe       P-KGSDIFSINN-SQINSSNYDIPQFKNNNGFKFIQDQQVYEES------GNFSIAS---
WNK_Spur        ----PTIPAQQQ-S-------QPQQI--Q--------------QQPPQQQ--Q-LQQHQI
AqueK219_Aque   GGVGSEGPSASNSP-------NVPHKITG--------------G------TAM-TTP---
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------------------------S---AAVPVPTTM-----------------------
CG7177_Dmel     QQQLQQQQLQQQQQIQQQQLQQQQL---QQQQFVQQYAQ-------AMPQQQHQQLVTGS
Wnk1_Mmus       ----------------------------MGQPIPTSLLP-------QYPV---------S
Wnk2_Mmus       ------------------------S---LTTPLPT--SP-------ALPM---------Q
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ----------------------------VGQPLPTPLLP-------QYPV---------S
Wnk2_Hsap       ------------------------S---LAAPLPPA-SP-------ALPL---------Q
17822_Tthe      ------------------------EQTT---ALEE--NK-------EQLL---------Q
8961_Tthe       ------------------------ETPDLGCNL-----NNCQTNIEQQEY---------E
WNK_Spur        QQQQQHQAQHQQQQQQPQSTPHSQS---QLQPQPQQ-SV-------QQPV---------Q
AqueK219_Aque   ------------------------S---ENSEDSEK-ES-------VEDE---------Q
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    --IHVPKPS-------------EIPVQ---------------------------------
CG7177_Dmel     Q-VMAPHQHQQPIQIPVQMQVPPTSVAPPIQ-----HTYNQQGGQVTL------------
Wnk1_Mmus       ----------------------QIPISTP-------HVSTAQTGFSSVPITMAAGINQPL
Wnk2_Mmus       A-VKLPHPPGTPLAVPCQTIVPNAPAAIP-------LLAVAPQGVAALSIHPAVA-QIPA
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ----------------------QIPISTP-------HVSTAQTGFSSLPITMAAGITQPL
Wnk2_Hsap       A-VKLPHPPGAPLAMPCRTIVPNAPATIP-------LLAVAPPGVAALSIHSAVA-QLPG
17822_Tthe      A-NQNEHL----------------------------------------------------
8961_Tthe       T-SKYDPI----------------------------------------------------
WNK_Spur        TQAQVQVPTQLPQSLPSQQQQQQQQAQTQQFVQQTANYTQFPQGQA-YQQSVSQG-QLPQ
AqueK219_Aque   F-VSKKHSELTSAPVSSK-SLPSSSKTSP-------NLSKGKGGEEEREEHQSLS-AKGQ
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       -----------------------------------ALQPPGGVPSS--------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    -NVA-----TTAAP--VAAN--NVP-PSPA------------------------------
CG7177_Dmel     ---------SDAQQ-QQHPGFSAVP-QQA----APFIQQPTQQPIQ-------LS---MP
Wnk1_Mmus       LTLA-----SSATA-SSIPG--GSP-VVPNQ-LPTLLQPVNQLQSQ--------------
Wnk2_Mmus       QPVY-----PAAFP-QMVPG--DIP-PSPHHTVQSLRATPPQLASP--------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       -----------------------------------ALQPPGGLPSS--------------
Wnk1_Hsap       LTLA-----SSATT-AAIPG--VST-VVPSQ-LPTLLQPVTQLPSQ--------------
Wnk2_Hsap       QPVY-----PAAFP-QMAPT--DVP-PSPHHTVQNMRATPPQPALP-----PQPTLPPQP
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        QPIQQPLQQPIQQP-LQQPS--QVP-STPQRTASDQHAKVTRTVSGGSQHAPQPQVQPQA
AqueK219_Aque   GDIV-----NRTYSEDVHQS--DLSSGSATNS----------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    --------------------------------------------PFKTEDI---------
CG7177_Dmel     LE-------Q------------------------------QLQQLLHSQPAQQQQA----
Wnk1_Mmus       ---------------------------------------------VHPQLLQPTTVQSIG
Wnk2_Mmus       ---------------------------------------------VPPQPVQPSV-IH--
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ---------------------------------------------VHPQLLQPA-VQSMG
Wnk2_Hsap       VLPPQPTLPPQPVLPPQPTRPPQPVLPPQPMLPPQPVLPPQPALPVRPEPLQP----H--
17822_Tthe      ---------------------------------------------------NQESQQQVN
8961_Tthe       ---------------------------------------------------NQQNANQLE
WNK_Spur        ------------------------------------------------------------
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      -----------------------------------------------HVPAN--------


Wnk4_Hsap       ---------------------------------------L-AESHLC--LPSAFALSIPR
Wnk3_Hsap       --LVQGQS----------------------------TVLP--------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     ----MSQQ----------------------------QQQP-LVQQQQLPLVQQQPPLVQQ
Wnk1_Mmus       IPANLGQA----------------------------AEGP-LPSGDV--LYQGFPSRLPP
Wnk2_Mmus       LP----EQ----------------------------AAPT-AASGTQ--VLLGH----PP
Wnk3_Mmus       --VVQGQS----------------------------SVMP--------------------
Wnk4_Mmus       ---------------------------------------P-AESHLC--LPSGFALSIPR
Wnk1_Hsap       IPANLGQA----------------------------AEVP-LSSGDV--LYQGFPPRLPP
Wnk2_Hsap       LP----EQ----------------------------AAPA-ATPGSQ--ILLGH----PA
17822_Tthe      QEQNIQKDDKQN-SHEEHNDDEN--DNLKQKYYMNKN-----------------------
8961_Tthe       SEQIMQNDS-QNMKSNSDGSSQTSSMSINQGIYLN-------------------------
WNK_Spur        ------TQ----------------------------SQPIQQ-------QMQ----LLPP
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       S-----------------------------------------------------------
Wnk3_Hsap       VHVLGP------------------------------------------------------
C46C2.1_Cele    ------------------------------------------------------QTPTLA
CG7177_Dmel     QQPLVQHQQPSV------------------------------------------------
Wnk1_Mmus       QYPGDSNIAPSSNVASVCIHS-TVLAPPSMP--------------TEAL-ATQGYFPTVV
Wnk2_Mmus       SYTAD----VAAPVSAVSLPP-AVLSPP-LP--------------DTLLPTVPDLLPKVP
Wnk3_Mmus       IYAAGV------------------------------------------------------
Wnk4_Mmus       S-----------------------------------------------------------
Wnk1_Hsap       QYPGDSNIAPSSNVASVCIHS-TVLSPP-MP--------------TEVL-ATPGYFPTVV
Wnk2_Hsap       PYAVD----VAAQVPTVPVPPAAVLSPP-LP--------------EVLLPAAPELLPQFP
17822_Tthe      -------IIFTNNNGMIT----QILPAPEKRLDEEFKMRKITEDSKEI-QEEDRLYDNNI
8961_Tthe       ----------------------------------------------------------TI
WNK_Spur        SQS-----AQQQQHASVTNTT-SVLKQS-IP--------------ATQQSGQPSHVPQVC
AqueK219_Aque   -------------TQSINVNS-VSDATPT----------------GKDL-ARSASFYSGS
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       -------------------T--VVSQPQV-------------------------------
C46C2.1_Cele    QNTVPRT-----------------------------------------------------
CG7177_Dmel     ---------------QHQQP--LVQQPQ--------------------------------
Wnk1_Mmus       QPYVESTPLVPMGSVG-GQV--QVSQPAV-------------------------------
Wnk2_Mmus       SS----------------------------------------------------------
Wnk3_Mmus       -------------------G--VVSQSQI-------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       QPYVESNLLVPMGGVG-GQV--QVSQPGG-------------------------------
Wnk2_Hsap       SS----------------------------------------------------------
17822_Tthe      QSRVQNNDSISFYNQG-GKNSENISFSQIN-----------ASNAKEVVE--DFSFDKQT
8961_Tthe       N-------------------------YSLAFNEYSQDTQYRYAFT-LEIRDSLYPFDITV
WNK_Spur        QNSVQQTQQQQIQQVGQGQP--QQQQQQQ-------------------------------
AqueK219_Aque   QTQSETQTLIA--------------HSQT-------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ----------------------------------------SPLTV---------------
C46C2.1_Cele    ------------------------------ISTDASGL--VINTP---------------
CG7177_Dmel     ---------------------------QQQPQPQNQQPQPQTQQT-HVV--QQQPPQQQP
Wnk1_Mmus       ------------------------SLTQQPPTTSSQQA--VLEST---------------
Wnk2_Mmus       -------------------------LAP-TVVAASQSA--PAQTSSLLL--PTNP-----
Wnk3_Mmus       ----------------------------------------SPLTI---------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ------------------------SLAQ-APTTSSQQA--VLEST---------------
Wnk2_Hsap       -------------------------LAT-V-SASVQSV--PTQTATLLP--PANP-----
17822_Tthe      K--------------TQIIDKKLEQQEEQKQTQNSQVL--IIDSAQNRRDIQSADFSQSP
8961_Tthe       DKNLINNGSYNKESITNLIKEALNQIECQDL-EKLHNF--IIDDAVAKCKLLFKD-----
WNK_Spur        ------------------------QQ--QQQQQQQQQQ--QLQQL--QQ--QQQQPQHHP
AqueK219_Aque   ------------------------S---LSGTAVSQSI--AAQSSSGSA--QSQT-----
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       -----------------------QKVPQIKPV----------------------------
C46C2.1_Cele    -----------------------ASIASPSPA----------------------------
CG7177_Dmel     AVE------------------QISQISSQVPVQ---------------------------
Wnk1_Mmus       -----------------------QGVSQAAP-----------------------------
Wnk2_Mmus       PLP------------------TGPAVAGPCPA----------------------------
Wnk3_Mmus       -----------------------QKVSQIKPV----------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       -----------------------QGVSQVAP-----------------------------
Wnk2_Hsap       PLP------------------GGPGIASPCPT----------------------------
17822_Tthe      ----------------------------NYHTKKSEGNNTPITPIVNNILYAFKNPQSDE
8961_Tthe       ---------------------------------------------INNAYFMFMNLVSEF
WNK_Spur        IQPGTTLGQPHMMSAPSYVSIAASSAAAVAT-----------------------------
AqueK219_Aque   --T------------------SSSSISSGYHSQ---------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       ------------------------------------------------------------
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ------------------------------------------------------------
Wnk2_Hsap       ------------------------------------------------------------
17822_Tthe      K---------HKLIRQKSKSGEDFYVQKLQNIQNEDIQVSYSENLSMNGLQNNQQEYSK-
8961_Tthe       QAKKKKFNKKE------------------------EM--AKKNSLSPSKSSNFQLNLTPD
WNK_Spur        ------------------------------------------------------------
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       --------------------S--------------------------------------Q
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     -----------------QENL--------------------------------------Q
Wnk1_Mmus       --------------------P--------------------------------------E
Wnk2_Mmus       ----------------VQLMV--------------------------------------E
Wnk3_Mmus       --------------------S--------------------------------------Q
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       --------------------A--------------------------------------E
Wnk2_Hsap       ----------------VQLTV--------------------------------------E
17822_Tthe      -----------------------------PSKGQSPKKIQDQLTNDQQYERILRRENDMN
8961_Tthe       EKKQSLQQIQANISTNQQILVAKAIQDDDDDDNNSDHEIEDAVFYNA---YCDDYNR---
WNK_Spur        --------------------A--------------------------------------V
AqueK219_Aque   ----------------S---S--------------------------------------S
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ----------------------GPGSDF--------------------------------
Wnk3_Hsap       PVGAEQ-----------Q-AALLKPD----------------------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     PIQV--------------NKDANVATDA--------------------------------
Wnk1_Mmus       QTPITQ-----------S-QPTQPVPLV--------------------------------
Wnk2_Mmus       VAQEEQ-----------VSQDKPPGPPQ--------------------------------
Wnk3_Mmus       PIGAEQ-----------Q-ATLQNPD----------------------------------
Wnk4_Mmus       ----------------------GPGSDF--------------------------------
Wnk1_Hsap       PVAVAQ-----------T-QATQPTTLA--------------------------------
Wnk2_Hsap       PVQEEQ-----------ASQDKPPGLPQ--------------------------------
17822_Tthe      -------------------------NSQKNENLNSQNNLQNI---GGVEHSE-FI-----
8961_Tthe       -----------------------------------QDEYNHISSHNPQEYTQNQIYYQNN
WNK_Spur        PVSLATTTSNASAPAWHLAQDNRPQTVD--------------------------------
AqueK219_Aque   ALALS------------SSSSTPPS-----------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      -----------------------LDTAS--------------------------------


Wnk4_Hsap       -SPGDSYASDAA----SG-------------LSDVGEGM----------GQMRRP-PGRN
Wnk3_Hsap       --LVRSLNQDVA----TTK-----------ENVS-SPDN-PSGNGKQ----DRIK-QRRA
C46C2.1_Cele    ----P-SATDVA----STTAPVTPAPTP-TTTTDGGAAA-AS--------TTT---EN--
CG7177_Dmel     -MSLNSAHGA--LEPAPKT-------EPQ-NSADAEKQQKQTGTG------TR----SQK
Wnk1_Mmus       -TSADSAHSDVA----SG-------------MSDGNENA-PSSSGRHEGRTTKRH-YRKS
Wnk2_Mmus       -SSESFGGSDVT----SGR-----------DLSDSCEG--TFGGGRLEGRTARKH-HRRS
Wnk3_Mmus       --FVRSLNQDVT----SVK-----------ENTN-NPDT-PSGNGKQ----DRNK-QRRA
Wnk4_Mmus       -SPGDSYASDAA----SG-------------LSDMGEG-----------GQMRKN-PVKT
Wnk1_Hsap       -SSVDSAHSDVA----SG-------------MSDGNENV-PSSSGRHEGRTTKRH-YRKS
Wnk2_Hsap       -SCESYGGSDVT----SGK-----------ELSDSCEG--AFGGGRLEGRAARKH-HRRS
17822_Tthe      -------------------------------------------SNQESGASLDKY-SNKS
8961_Tthe       YSRLDNTQNNIK----N-----------------DHLTH-QTSEPSHQNHSRQQS-YI--
WNK_Spur        -AS--KVGSDGQAWSSPGLE-------RKDVLTDAASAY-PSGTGEESGAEGSQNVEKRQ
AqueK219_Aque   -VEADTTQSNGS----SG----------------------PGGSGG----SFR-------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      -----SVV--------------------------------------------I---KRRP


Wnk4_Hsap       -------------------------------------------------------L----
Wnk3_Hsap       -------------------------------------------------------S--CP
C46C2.1_Cele    --------------------------------------------------------KEEK
CG7177_Dmel     -------------------------------------------------------PRRSN
Wnk1_Mmus       -------------------------------------------------------VRSRS
Wnk2_Mmus       -------------------------------------------------------TRARS
Wnk3_Mmus       -------------------------------------------------------S--CP
Wnk4_Mmus       -------------------------------------------------------L----
Wnk1_Hsap       -------------------------------------------------------VRSRS
Wnk2_Hsap       -------------------------------------------------------TRARS
17822_Tthe      LENTNNDSNKRASPSNGVVYYDDLANQFTMQNDHSDIYSNHEYQQDYSKQPSMVEIQQYQ
8961_Tthe       ---------------------------------------------------SSHSVQLNS
WNK_Spur        ---------------------------------------------------------GKK
AqueK219_Aque   -------------------------------------------------------SKKGS
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      -------------------------------------------------------TKSSL


Wnk4_Hsap       --RR--RPRSR--LRVTSVSD-QNDRVVECQL-QTHNSK-MVTFRFDLD-GDSPEEIAA-
Wnk3_Hsap       RPEK--GTKFQ--LTVLQVST-SGDNMVECQL-ETHNNK-MVTFKFDVD-GDAPEDIAD-
C46C2.1_Cele    RKSN--KRKVV--MEILGCDESRNFALVSCRL-DTS-HK-SVTFQFAPG-TDKPCTIAT-
CG7177_Dmel     RSG--NERIPK--LSVTSV---DEGSVINCHM-EN-KLK-TITFKFDIGDRDETASDIT-
Wnk1_Mmus       RHEK--TSRPK--LRILNVSN-KGDRVVECQL-ETHNRK-MVTFKFDLD-GDNPEEIAT-
Wnk2_Mmus       RQER--ASRPR--LTILNVCN-TGDKMVECQL-ETHNHK-MVTFKFDLD-GDAPDEIAT-
Wnk3_Mmus       RPEK--GTKFQ--LTVLQVSV-SGDNMVECQL-ETHNNK-MVTFKFDVD-GDAPEDIAD-
Wnk4_Mmus       --RR--RPRSR--LRVTSVSD-QSDRVVECQL-QTHNSK-MVTFRFDLD-GDSPEEIAA-
Wnk1_Hsap       RHEK--TSRPK--LRILNVSN-KGDRVVECQL-ETHNRK-MVTFKFDLD-GDNPEEIAT-
Wnk2_Hsap       RQER--ASRPR--LTILNVCN-TGDKMVECQL-ETHNHK-MVTFKFDLD-GDAPDEIAT-
17822_Tthe      DQES--NDVPPYSLTVLEEK-ELKNQKFLIKFKFQHFNR-MQTFEIDNT-HEDFSEQSIF
8961_Tthe       IQEQ--TQNF--KFM------NANPQYFNNQQQ-NKNSQNIQLFSIDSH-NQKNSPAIPQ
WNK_Spur        KHSKTSKKRPK--LSIIS--V-DEDQVIECSL-ETHRGD-TIVFKFSED--DQLDGIVS-
AqueK219_Aque   RTKD--SKRIK--LKFN--EK-VKDNVISCSL-QTSAGQ-VINFKFSLD-YDKPNEIFN-
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      TSR--IN--------------------VE----IS-LPN-QVSFVYVLSLMDKPVEIVD-


Wnk4_Hsap       ----AMVYNEFIL-----------------------------------------------
Wnk3_Hsap       ----YMVEDNFVL-----------------------------------------------
C46C2.1_Cele    ----KLLAEDCLL-----------------------------------------------
CG7177_Dmel     ----KMFEP---------------------------------------------------
Wnk1_Mmus       ----IMVNNDFIL-----------------------------------------------
Wnk2_Mmus       ----YMVEHDFIL-----------------------------------------------
Wnk3_Mmus       ----YMVEDNFVL-----------------------------------------------
Wnk4_Mmus       ----AMVYNEFIL-----------------------------------------------
Wnk1_Hsap       ----IMVNNDFIL-----------------------------------------------
Wnk2_Hsap       ----YMVEHDFIL-----------------------------------------------
17822_Tthe      AFAQIKAAELEIVDLEEQFAYDLYNLVYERYNQFHSQVSQGQRKIVQED--------SSS
8961_Tthe       SVQK-------------------------------------NQIFPTPPQFSEKNQCQSP
WNK_Spur        ----NLTVAKWVH-----------------------------------------------
AqueK219_Aque   ----NLVKTGHLS-----------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ----ELEMVH--------------------------------------------------


Wnk4_Hsap       ------PSERDGFLRRIREIIQRVETLLKRDTGP-MEAAEDTLSPQ--------------
Wnk3_Hsap       ------ESEKEKFVEELRAIVGQAQEILHVHFAT-ERA--TGVDSITVDSNSS-------
C46C2.1_Cele    ------KVHVHIVEAQLGEVIQLINSDGKKGVGT-KLATV--LDP---------------
CG7177_Dmel     -------------------TIHGVETLPSGGGGA-EQ-----------SNCNLT--LE--
Wnk1_Mmus       ------AIERESFVAQVREIIEKADEMLSEDVSV-EPEGDQGLESLQGKDDYG-------
Wnk2_Mmus       ------PAERETFIEQMKDVMDKAEDMLSEDTDA-DHGSDTGTSPPHLGTCGL-------
Wnk3_Mmus       ------ENEKEKFVEELRAIVGQAQEILHVHSAV-EKS--IGVDSVALESNSN-------
Wnk4_Mmus       ------PSERDGFLSRIREIIQRVETLLKRDAGP-PEAAEDALSPQ--------------
Wnk1_Hsap       ------AIERESFVDQVREIIEKADEMLSEDVSV-EPEGDQGLESLQGKDDYG-------
Wnk2_Hsap       ------QAERETFIEQMKDVMDKAEDMLSEDTDA-DRGSDPGTSPPHLSTCGL-------
17822_Tthe      PN-YTQPYCIEIFIRHYQNYMKEIEEYLKVESSH-NLKVRQSKEQIQLHRFHLN--QQE-
8961_Tthe       PNHYNFCKLIDNFIDYYKKYWEQNYEQISYETQE-LLKFRQQKELIELQRLHIA--QRDA
WNK_Spur        ------EQHAGLFKEQLLKVMEDAKRLG-PGLHL-QP----GPSSSTVGDDTG-------
AqueK219_Aque   ------QLEGTDFISQFQKVVDTVRSKSTVDSTSSDTKKNPG-GPLRSTSVSYSSIVK--
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      -------------------D----------------------------------------


Wnk4_Hsap       ------------------------------------EEPA-PLPA-------------LP
Wnk3_Hsap       -------------------------QTGSSE-------------QVQINSTSTQTSNE--
C46C2.1_Cele    ----------------------------------NSTEPP-TITAV------------MP
CG7177_Dmel     ---ARS------------------------------------------------------
Wnk1_Mmus       -------------------------FPGSQKLEGEFKQPI-AVSS-------------MP
Wnk2_Mmus       -------------------------ATGEENR---------------------------Q
Wnk3_Mmus       -------------------------QTGSSE-------------QVLINSASTQTSNE--
Wnk4_Mmus       ------------------------------------EEPA-ALPA-------------LP
Wnk1_Hsap       -------------------------FSGSQKLEGEFKQPI-PASS-------------MP
Wnk2_Hsap       -------------------------GTGEESR---------------------------Q
17822_Tthe      -------------------NQIDYESQAQSQIVQKSPQTIQKVVA-------------VN
8961_Tthe       WLTN--QMNLTANQYE---KQDAFQLQGKQGIQSQSNFII-YQSD-------------QA
WNK_Spur        -------------------------TITSQQLQEGVVPPS-PGTAVNSSDASPPSGDESQ
AqueK219_Aque   ---QDSDQSKHSESYQKGGARSDSPYDGSGQLGGVKRDGL-A------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       V-----------PLP-----------------------------DPSNEELQSST-----
Wnk3_Hsap       --------------SAPQS-----SPVGRWRFC--------INQTIR-------------
C46C2.1_Cele    K-----------DSS---------------------------------------------
CG7177_Dmel     ----------------------------------------HLSNIPNAKEPQLNVS----
Wnk1_Mmus       Q-----------QIGVPTSSLTQVVHSAGRRFI--------VSPVPESRLRESKV-----
Wnk2_Mmus       S-----------QANAPVYQ-QNVLHTGKRWFI--------ICPVAEHPAT---------
Wnk3_Mmus       --------------SAPQS-----SPVGRWRFC--------INQTIK-------------
Wnk4_Mmus       --------------------------------------------GPPNAEPQRSI-----
Wnk1_Hsap       Q-----------QIGIPTSSLTQVVHSAGRRFI--------VSPVPESRLRESKV-----
Wnk2_Hsap       S-----------QANAPVYQ-QNVLHTGKRWFI--------ICPVAEHPAP---------
17822_Tthe      Q-----------QQLLPQQNINYANNSNNQDFF--------ESPE---------------
8961_Tthe       NNIQTNHSVLDISNISNVKDIDNDNHISPQLK----------------------------
WNK_Spur        Q-----------QLNAPQQSFE--MAVGKHLTAESQQGEQQLRPVENQHLPLSRKGSSPL
AqueK219_Aque   --------------------LSEASPHSRRKFQ--------VSDVFV-------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       -------SLEHRSWTAFSTSSSSPGTPLSPGN----------------------------
Wnk3_Hsap       -----------------NRETQSPPSL-Q---HS------MSAVPG--------------
C46C2.1_Cele    ---------------AATASNTKPKIEIEKTPPT----RDASQEPN-NVQVT---NVRKV
CG7177_Dmel     ----------------------TPPTTTSTMSSSSTASRDAPNSSN-DVTIGSGSVSRKT
Wnk1_Mmus       -------FTSDISDPVVASTSQAPGMNLSHSASS--------------------------
Wnk2_Mmus       -----------------DTSESSPPLPLSSLQPE------ASQDP---------------
Wnk3_Mmus       -----------------NREAQSPPSL-Q---PS------MAMVPG--------------
Wnk4_Mmus       -------SPEQRSWAAFSTSPSSPGTPLSPGA----------------------------
Wnk1_Hsap       -------FPSEITDTVAASTAQSPGMNLSHSASS--------------------------
Wnk2_Hsap       -----------------EAPESSPPLPLSSLPPE------ASQGPCRGLTLPCL-PWRRA
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        IVNQPQQMGSEDSDQTRPKPNQSPPAAIENMPSQ--------------------------
AqueK219_Aque   -----------------ERPNEKPSITSQGSAES--------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       -----------------------PFSPGTP---------------IS--PGPIFP---IT
Wnk3_Hsap       -----------RH----------------P----L--PSP--KNTS--------------
C46C2.1_Cele    SQE-----S---------N-AESVQSIPRPGGIIV--MSP--TNQTDSAPPPTGA---AA
CG7177_Dmel     STASEYTSLSI--------D----YMPDSNI--TPTGPEPPLDDG--KDKKPCSLAIARM
Wnk1_Mmus       --------LSLQQAF---SELKHGQMTEGP----N--TAP--PNFNH-MAGPTF------
Wnk2_Mmus       ----------------------------------A--PYP--DQLSL-TDKPSFP---AA
Wnk3_Mmus       -----------LH----------------P----F--PSS--RNTS--------------
Wnk4_Mmus       -----------------------PFSPGTP----P----------VF--PCPIFP---IT
Wnk1_Hsap       --------LSLQQAF---SELRRAQMTEGP----N--TAP--PNFSH--TGPTFP---VV
Wnk2_Hsap       ACG-----AVFLSLF---S-AESAQSKQPP----D--SAPYKDQLSS-KEQPSFL---AS
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        --------VPVQQSHHLQMELRT--------------------------PQPVYP---S-
AqueK219_Aque   --------MTVMSPV---H-------SEDT----C------------I------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       -----------------------------------NKEISRDTLLTIENNPCHRALFTSK
C46C2.1_Cele    KPSRFQVTKSADPIA-----------TPI-SSSIS-------------------------
CG7177_Dmel     QKLLESAG-NGAPRSLN---------LPL-N-----------------------------
Wnk1_Mmus       SPFLASIAGVQTVAAST-------PSVSVPITSSPLNDISTSVMQSETALPTEKGIVGVT
Wnk2_Mmus       QQLLSQAGSSNPPGGAS---------APL-APSSPP------------------------
Wnk3_Mmus       -----------------------------------NQAISQNTVFTIENNPGHRELFTSK
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       PPFLSSIAGVPTTAAAT---------APVPATSSPPNDISTSVIQSEVTVPTEEGIAGVA
Wnk2_Hsap       QQLLSQAGPSNPPGAPP---------APL-APSSPP------------------------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        -----QAGVPDQGMMQGMPMMGAYSMMPM-LSSQG-------------------------
AqueK219_Aque   --------------------------LPPPSSSSSSSDNKST------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       -SEHKDVVDGKISECASVETKQPAILYQVEDNRQIMAPVTNSSSYSTTSVR---AVPAEC
C46C2.1_Cele    ---------------------------------------------TATVIP---IVAATP
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       TTSTGVVASGGLTTMS-----------------------------VSE-SPTSSSAVSSS
Wnk2_Mmus       ---------------------------------------------VTTVIP---AAPATS
Wnk3_Mmus       -LDHKDVVDGKIGEHASIETEQSSISYQVEDDRQIMTPATDNSNYSAALVC---PVPGEC
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       T-STGVVTSGGLPIPP-----------------------------VSE-SPVLSSVVSSI
Wnk2_Hsap       ---------------------------------------------VTA-LPQDGAAPATS
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ---------------------------------------------NVVF-----------
AqueK219_Aque   ------------------------------------------------QDPT-SVFHSTS
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ---------------------------------------------------SPPCHPSPS
Wnk3_Hsap       EGL-------TKQASIFIPVYPC----------------HQTASQADALMSHPGE-----
C46C2.1_Cele    TNI-------TSEPVIVQPIT----------------------AQVITHLA----TP--S
CG7177_Dmel     -----RHLKI-QEDLKHTRSL-DDLTAVKITFDMPNKAALDTSENAQQATEAEAEKPK--
Wnk1_Mmus       TVPAVVTVST---PSQPVQAS-TSGSIASSTGSFPPGTFSTTTATTMGSVVAPDAKPPT-
Wnk2_Mmus       TVPE----------------S-A----------------AGTAMQAGGPGTHQG------
Wnk3_Mmus       EAL-------TSQAGMFMPTYPN----------------QQAAVLADVHIAYPGE-----
Wnk4_Mmus       ---------------------------------------------------SPSCYPCP-
Wnk1_Hsap       TIPAVVSISTTS-PSLQVPTS-TSEIVVSSTALYPSVTVSATSASAGGSTATPGPKPPA-
Wnk2_Hsap       TMPE----------------P-A----------------SGTASQAGGPGTPQG------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        -VPMATQA--GAPQMYMHPQQ-A----------------QQMYMQQQ------------M
AqueK219_Aque   VLPT----------------C-T----------------LGTGD-KGNLGDT----P--S
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       PFSPISSQVSS-------------------------------------------------
Wnk3_Hsap       STQ---------------------------------------------------------
C46C2.1_Cele    PVS---HSLSS-------------------------------------------------
CG7177_Dmel     ---DKSGQAVG-------------------------------------------------
Wnk1_Mmus       ---VLLQQVAS-------------------------------------------------
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       SVP---------------------------------------------------------
Wnk4_Mmus       -----FSQVSS-------------------------------------------------
Wnk1_Hsap       ---VVSQQAAG-------------------------------------------------
Wnk2_Hsap       ------------------------------------------------------------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        PMQ----QHLSQQPPMQQHQQPPMQQLQQQPPIMQHQQQPPMQQQQQPQQQLPMHQQQPP
AqueK219_Aque   SVA---------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       --------------------NPSPHPTSS----PLPFSSSTPEFPVPLSQ----------
Wnk3_Hsap       -------TSGNS-L-T-------------------TL-------------------AFDQ
C46C2.1_Cele    --------------------NS------------SPSATTHSN-MSSIQS-------TTS
CG7177_Dmel     -----NQG-TGA-----------ANTLEQLKIELENITHAHA-FASAVVA-------SIN
Wnk1_Mmus       -----NTA-GVAIVTSVSTTTPFPGMASQ---PSLPLSSSTSA-PTLAET-------MVV
Wnk2_Mmus       -----PAS-VHE--------------------TLQPLAETRSA-QCTAQP-------LST
Wnk3_Mmus       -------IGGNAALTS------------------VLV-------------------SSDQ
Wnk4_Mmus       --------------------NPYPQAPSS----LLPLSSSASQVPLP-------------
Wnk1_Hsap       -----STT-VGATLTSVSTTTSFPSTASQ---LCIQLSSSTST-PTLAET-------VVV
Wnk2_Hsap       -----LTS-ELE--------------------TSQPLAETHEA-PLAVQP-------LVV
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        MQQQPLPS-VQD--------------------QVQPLLQQQPTQP---------------
AqueK219_Aque   -------T-GNS----------------------SAISSASSS-YSNLQPSGTGTITTVE
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       KPQTLSVQQPAMDAEFISQEGETT-----VNTEAS-------------------------
C46C2.1_Cele    VPGRRFTVQPVSQAES-------G--------------ISSSISTPHPEPTPA-------
CG7177_Dmel     --NRAP-HQASPAM----------------------------------------------
Wnk1_Mmus       --SAHS-LD--------------------KASHSSTAGLGLSFCAPSSSSSSG-TAV-ST
Wnk2_Mmus       --GQGP-CTPALEASRCST----GLGEPISTREVSTQGEPLPASVP--EPSPP-TGATQS
Wnk3_Mmus       KPQSLSVQQPTIDAEFISKEGETT-----VNTETS-------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       --SAHS-LD--------------------KTSHSSTTGLAFSLSAPSSSSSPG-AGV-SS
Wnk2_Hsap       --GLAP-CTPAPEAA--------------STRDASAPREPLPPPAP--EPSPH-SGTPQP
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ----------------------------IQQGGQQAQIPPQQLQQV--QPTQPGQQVATS
AqueK219_Aque   APNKKFEIEDVIDPETLS-------------TE-SSCENLIPDDKA--E-----------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ---CP---WS--SLPTTSPPTFSPTCSQV-TLSSPF--FPPCPSTSSFPSTTAAPLLSLA
Wnk3_Hsap       -------------------------SPK--TVIPT--------QTPG-------------
C46C2.1_Cele    -----------------------------------I--TSCPPPVPSVPPVV-S------
CG7177_Dmel     -----------------SSLKATSGQPQTQEITKPN--NGAGPSVPSVGQNTPTAALTSA
Wnk1_Mmus       SVSQP---GMVHPLVISSAVVSTPGLPQ--PVVPTS--TPLLPQVPNIPPLV-QPV----
Wnk2_Mmus       VPGQP---PPPLPITVGAISLAAPQ-----------------------------------
Wnk3_Mmus       -------------------------SPK--AVIAT--------QTPG-------------
Wnk4_Mmus       --------SS--SLPISAPLPFSPSYPQD-PLSPTS--LPVCPSPPSLPSTTAAPLLSLA
Wnk1_Hsap       YISQP---GGLHPLVIPSVIASTPILPQ--AAGPTS--TPLLPQVPSIPPLV-QPV----
Wnk2_Hsap       ALGQP---APLLPAAVGAVSLATSQ-----------------------------------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        VQGQAHAQPHQQPQTTAALSTAAPT---Q-S----------------VAG-GAQPQQSQA
AqueK219_Aque   --------------------------PKN-EVTPTESSTIIKDDEST-------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       SAFSLA------VMTVAQSLL-------------S-------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------------NGTLNLEVA----------PKQTPSATNQNVDTQHSSSTASTA--TLV
CG7177_Dmel     RGSGSS------VYNSRRTSI--DNSVGSDMHLHTATNLEGTVSNP------DPIPTEAS
Wnk1_Mmus       ----VN------VPAVQQTLI----------HS-Q-------------------------
Wnk2_Mmus       ----------------------------------L-------------------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       SAFSLA------VMTVAQSLL-------------S-------------------------
Wnk1_Hsap       ----AN------VPAVQQTLI----------HS-Q-------------------------
Wnk2_Hsap       ----------------------------------L-------------------------
17822_Tthe      ----------IN------------------------------------------------
8961_Tthe       -----------D------------------------------------------------
WNK_Spur        KAAQVAGVARLKELDHKLSQLHKKPNP----HQ-Q-------------------------
AqueK219_Aque   ---------------------------------------SVELSTPPTFSDEDTLTYARV
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ----------PSPGLLSQSPPAPPSPL-----------P---------------------
Wnk3_Hsap       --------------LEPTT-LQPTTVL-----------ESDGERP--------------P
C46C2.1_Cele    S---------ETPATVHVTPISVPAP---------------VQE--------------PL
CG7177_Dmel     VGITIATGHEKQLSKQPSLEKPSATSI-----------LTNNSDPPQRNPSNGSINQ---
Wnk1_Mmus       ----------PQPALLPNQPHTHCPEM-----------D--ADTQ--------------S
Wnk2_Mmus       ----------PSPPLGPTAPPPPPSAL-----------ESDGEGP-------------PP
Wnk3_Mmus       --------------FEPAV-ILPATIL-----------ESDGERP--------------P
Wnk4_Mmus       ----------PSPGLLSQSPPAPPGPL-----------P---------------------
Wnk1_Hsap       ----------PQPALLPNQPHTHCPEV-----------D--SDTQ--------------P
Wnk2_Hsap       ----------PSPPLGPTVPPQPPSAL-----------ESDGEGP-------------PP
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ----------QTPAKVPSQPPTMLQQQ-----------ISQ--GQ--------------S
AqueK219_Aque   KEV--ESSSKPHPPTSTNPPMYPPYSVQPVDPPQPLLLSPFSRIP----PTHGTLLENPL
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       KLEFADNRIKTLDEKLRNLLYQEHSISS-IYPESQKDTQSIDSPFSSSAEDTLSCPV---
C46C2.1_Cele    VIDHHSDVLTQLDSELRKVSGVSHSAS---------------------------------
CG7177_Dmel     ------NSIADLEKKLAALRNTENTEEARTQ----HVSR---------------------
Wnk1_Mmus       KAPGID-DIKTLEEKLRSL-FSEHSSSG-TQ----HASVSLETPLVVE--TTVTP-----
Wnk2_Mmus       RVGFVDNTIKSLDEKLRTLLYQEHVPTS-SA----SAGTPMEASD-RD--FTLEP-----
Wnk3_Mmus       KMEFADNRIKTLDEKLRNLLYQEHSISS-ICPESQKDTQSIDSPFSSSAEDILSYSM---
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       KAPGID-DIKTLEEKLRSL-FSEHSSSG-AQ----HASVSLETSLVIE--STVTP-----
Wnk2_Hsap       RVGFVDSTIKSLDEKLRTLLYQEHVPTS-SA----SAGTPVEVGD-RD--FTLEP-----
17822_Tthe      ----------NIQKKANNLNQ--QAIEQ-FQQPLYQNNQNINSGIGNIPNNALITNNNNN
8961_Tthe       ----------SIDMELSNMLLD-NPSSN-ILGNNYSKTHSQQ-IHQSSLHNSLSLNT---
WNK_Spur        NVPYH-----------------NQVSVS-VA----QLTTPNNSQSSAN--IVLTP-----
AqueK219_Aque   V---FD-GFMKFMHYMKLL-FEEPSIAA--L----LQQISINN-----------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ----T--EVIAISHCGIK--------------------------DSPVQSPNFQQTGS-K
C46C2.1_Cele    --------------------------------------------------------PS-T
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       ---------------GIT--------------------------TT-------AVAPS-K
Wnk2_Mmus       --------------------------------------------LR-------GDLPS-A
Wnk3_Mmus       ----P--EVIAISHCGIQ--------------------------DSPAQSPNFQQTGS-K
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ---------------GIP--------------------------TT-------AVAPS-K
Wnk2_Hsap       --------------------------------------------LR-------GDQPR-S
17822_Tthe      MNQNYNQNSTSYSNIGIT--------------------------NNNSNIPNNAIPGS-L
8961_Tthe       ----ANQNNLGL-MQQIQ--------------------------VEAIISPSNQSIGNQQ
WNK_Spur        ---------------QPVSNMLAPVFHPIQDERKASLMDAQSLPIH-------NYLPR-P
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       LLSNVAA------SQPANISVFKRDLNVITSVPS-------ELC----------------
C46C2.1_Cele    VVESLTS---------------------M--TPQ-------TIP----------------
CG7177_Dmel     -------VQEQK------------------------------------------------
Wnk1_Mmus       LMTSTTS------T-------------CL--PPT-------SLP----------------
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       ILSNVAA------SQPAHISVFKKDLNVITSVPS-------ELC----------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       LLTSTTS------T-------------CL--PPT-------NLP----------------
Wnk2_Hsap       -----------------------------------------EVC----------------
17822_Tthe      LNFNSNQ------NTQGNI------------------------ASHHLSPNSSANTFEEN
8961_Tthe       FIQNMQT------SEP----------------------------------TTSASISNKK
WNK_Spur        ASEPVPDFQTTPYV-------------DP--QQDSVQVVPEKSE----------------
AqueK219_Aque   -------------P-------------DQ--PPSSGSTANGHTP----------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      -------------FASGNI-------------------------KRHLSPQ---------
WNK_d_Smoe      -------------TES-----------------------------PTVEAG---------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ----------------------------------------------TVSSR---------
WNK_b-1_Smoe    ----------------------------------------------TVSSR---------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ----------------------SLPLPPPVAPGGQESPSPH-------------------
Wnk3_Hsap       --------------LHEMSSDASLPGDPEAYPAAVSSGGAIHLQT---------------
C46C2.1_Cele    --------------L----ACQTVPASIGQAPAVIAA--AHAA-----------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       --------------L----GAAGMPVMPVGTPGQVSTPGTHASAP---------------
Wnk2_Mmus       ---------------------------LS-------------------------------
Wnk3_Mmus       --------------LHEMSPDASLPGDPEAYPAAVSSDGTIHLQT---------------
Wnk4_Mmus       ----------------------SLPLS--LASCDQESLSAQ-------------------
Wnk1_Hsap       --------------L----GTVALPVTPVVTPGQVSTPVSTTT-----------------
Wnk2_Hsap       --------------G----GDLALPPVPK-------------------------------
17822_Tthe      QEAQLQINFPPQ----------------------IQRSGSIQINAQSTQQNNMKNQIYIP
8961_Tthe       TNLPIRTPTPKQTLNES-----------------ISQKQSQ-------------------
WNK_Spur        --------------------ENQI----------------QIEQP---------------
AqueK219_Aque   --------------S----NGQ----SPTATNGYAPAPGSNGH-----------------
WNK_e_Smoe      ----MHSTDST-------------------------------------------------
WNK_a_Smoe      -LPCVDVASPP-------------------------------------------------
WNK_d_Smoe      -QASVKSRSPR-------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    -NSEVESLSPQ-------------------------------------------------
WNK_b-1_Smoe    -NSEVESLSPQ-------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ----------------------------------------------------------GG
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       ----------------------------------------------------------VG
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       ----------------------------------------------------------GG
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ------------------------------------------------------------
Wnk2_Hsap       ------------------------------------------------------------
17822_Tthe      QNNQYQIQLPQIVNKNQYAQTTTHQQQQQQIKQKYLKEEMLNAQSFNPREGRQDNKGISH
8961_Tthe       -----------------------------------------SIQSKNSQQNQNPQLAVNS
WNK_Spur        ----------------------------------------------------------A-
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       GY--FGL--S--------------------------------------------------
C46C2.1_Cele    --S---LIPN--------------------------------------------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       TAT--GVKP---------------------------------------------------
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       GY--FGL--S--------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       --S--GVKP---------------------------------------------------
Wnk2_Hsap       ------------------------------------------------------------
17822_Tthe      SQ--SFS--NISTQAIQKVKQSQSKHRLHHAENSNAQGMYSSNQQSQPINKSQTQQLSYF
8961_Tthe       YS--QNL--NNTQNSIQNQNNLNSNNEKIKTNTIN--SSNSSIIQTQPIRTHH-------
WNK_Spur        --RPVSPKP---------------------------------------------------
AqueK219_Aque   --S--AVNPA--------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      -----T------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       ------------------------------------------------------------
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ------------------------------------------------------------
Wnk2_Hsap       ------------------------------------------------------------
17822_Tthe      NQQNLSQQIQFQNPMQHQQQQQNSNFFQQGQQQQISQVNNSNYIFPQNNASQNMQQ-TPQ
8961_Tthe       ----GSIQISMQNPKTNNKMQQSDKLYYQNPLQQQ---------------QQ---L-QQQ
WNK_Spur        ------------------------------------------------------------
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      -----------------------------------------------------GPLSYSP
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------FTCPSLKNPISKK----SW-----
C46C2.1_Cele    ------------------------------------ASVPQSPSR--LDAETG-------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       ------------------------------------GTTPPK--P--TKTVVPPV-----
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       ------------------------------------FTCPSLKNPISRK----SW-----
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ------------------------------------GTAPSKPPL--TKAPVLPV-----
Wnk2_Hsap       ------------------------------------------------------------
17822_Tthe      SFPGRQ---LNQRQQKYS-YASEDTQQN---QQS--------------NLIKQGSHFKNQ
8961_Tthe       QQHFNP-QQQQQQFQQQT----FPQSSQQQIQQNKMNSKPPTP----KQIIS--------
WNK_Spur        ------------------------------------ASSPTKKSR----FSVSSV-----
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      HGEG---M-MFGRFEEVSV-GCLSTDTDSEP-----------------------------
WNK_a_Smoe      RGEG---T-MYGRFEEVYSGGSDPSEANAF--------------------------F---
WNK_d_Smoe      RLEGTSSS-MHGRFEEVTY-HPEGSDQYDAPH-----------------------IF---
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    NLEG---T-MHGRFEEFTY-QSLPMRSHATP-----------------------------
WNK_b-1_Smoe    NLEG---T-MHGRFEEFTY-QSLPMRSHATP-----------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       -------------------TRKLKSWAY--------RLRQS-------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       -------------------GTELSAGTV--------PCEQL-------------------
Wnk2_Mmus       ---------------------D--------------------------------------
Wnk3_Mmus       -------------------TRKLKSWAY--------RLRQS-------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       -------------------GTELPAGTL--------PSEQL-------------------
Wnk2_Hsap       ---------------------E--------------------------------------
17822_Tthe      SNHQVKLSSSQEQYTSK----------TPNIQDDSNNPYQL-------------------
8961_Tthe       ----------------QNNNFHFSNNLT--------PSSQV-------------------
WNK_Spur        -------------------EDKKDAAAV--------TEE-KPKEEISEGNAGSKTETVGD
AqueK219_Aque   --------------------------------------HMR-------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       --TSFF------------------------------------------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       --PPFP------------------------------------------------------
Wnk2_Mmus       -----K------------------------------------------------------
Wnk3_Mmus       --TSFF------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       --PPFP------------------------------------------------------
Wnk2_Hsap       -----A------------------------------------------------------
17822_Tthe      --PQQQQRQQQQNQQPQYQQHASH---STQLENDNSIRKNSQNNGQSNYNAINPPFFIQP
8961_Tthe       --AQQPLKPIKHNQQQV-KQNFIH---SATNSQDSSY------------FS--FQ-FMNE
WNK_Spur        KSSREP------------------------------------------------------
AqueK219_Aque   --PPV-------------------------------------------------------
WNK_e_Smoe      ----------EPT--TG-LDNNGH---FSPAEE---------------------------
WNK_a_Smoe      ---------SNESSDDG-EETSFP---ATPKSD---------------------------
WNK_d_Smoe      ------SSGSSEIREDG-DDWDLTGEVSSPVAT---------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ----------RENQETA-KLWDFH---STPVPD---------------------------
WNK_b-1_Smoe    ----------RENQETA-KLWDFH---STPVPD---------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       -----K--------RSKVRQ--VETE-E-MRSAIAPDPIPLT--------RESTADTRAL
C46C2.1_Cele    --------LAG--LHEKLEA--LKMEQD-RREDMGDDAIGTT--------TTDGKDEIPI
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       -----GPSLIQ--SQQPLED--LD--AQ-LRRTLSPETITVAPAVGPLSTMSSTTVTEAG
Wnk2_Mmus       -----TPSLTQ--QTQPSLE-----------------KSETAPAGWA-------------
Wnk3_Mmus       -----K--------RSKVRQ--VETE-D-KRSAIASDPIPLT--------REFSSDTRAL
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       -----GPSLTQ--SQQPLED--LD--AQ-LRRTLSPEMITVTSAVGPVSMAAPTAITEAG
Wnk2_Hsap       -----VSGRVQ--LPQPLVE-----------------KSELAPTRGA-------------
17822_Tthe      LDNKNGNQFTQGISQQNLKQQQTQ--NQ-FIKSLSPP----------------------G
8961_Tthe       IGGQPGTNQQSQISHSKIKSSQNL--NQYFYKSQTPP----------------------N
WNK_Spur        -----AIGMDK--DQEPARK--EE--KK-GRFTVAPAPCTVGDAV---------------
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ---------------TA-------------------------------------------
Wnk3_Hsap       NRC---------------KAMSGS-----FQRGRF----------Q--VITIPQQQSAKM
C46C2.1_Cele    DTL---------------KGLAEALGKVIHADGRE----------T--TPMPPDHP----
CG7177_Dmel     -----------------TSTGVEE-----PAQGQL----------KIDLQVAGPGGQVQT
Wnk1_Mmus       TRLQK---DGTEGHVTATSSGAGV-----VKMGRF----------Q--VSVTMDDAQKER
Wnk2_Mmus       ---LAQREQGASSPMTAESSSSNT-----LGCDSDAGQVASDSSTA--PSVPQDASGSS-
Wnk3_Mmus       SRC---------------KAMSGS-----FQRGRF----------Q--VITVPQQQPVKM
Wnk4_Mmus       ---------------TA-------------------------------------------
Wnk1_Hsap       TQPQKGVSQVKEGPVLATSSGAGV-----FKMGRF----------Q--VSVAADGAQKEG
Wnk2_Hsap       -----VMEQGTSSSMTAESSPRSM-----LGYDRDGRQVASDSHVV--PSVPQDVPAFV-
17822_Tthe      IQSRKETDQGKQKNLMIS-RPPSS-----GQQTRV------------QLTLNEQDVQQQI
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ------------------------------------------------------------
AqueK219_Aque   ---------------TSVSSSS--L----------GQQVYSLASVS--GGVAQSSASYA-
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       -----------------------EVES---EASPPPARPL--------------------
Wnk3_Hsap       TSFGIEHISV-------FS-ETNHSSEEAF--IKTAKSQLVEI-EPA-TQ---NP--KTS
C46C2.1_Cele    ------------------------------DLTDASTQ----------------------
CG7177_Dmel     NNSVQNG------------------SV-----VNTPTEVISSP-IQNVPLAINGIQLMYQ
Wnk1_Mmus       KNRSEDTKSV------HFESSTSESSV---LSSSSPESTLVKP-EPN-GISISGI--SLD
Wnk2_Mmus       -------VPT------HMDPKDQ--------NSSVPREALAAP-MQS-GPGSF-T-----
Wnk3_Mmus       MSFGKDHRPP-------FNKTTVQSSEQALTFAEAAVSQLIEV-EPA-MP---TH--KAS
Wnk4_Mmus       -----------------------ETEN---EASRNPAQPL--------------------
Wnk1_Hsap       KNKSEDAKSV------HFESSTSESSV---LSSSSPESTLVKP-EPN-GITIPGI--SSD
Wnk2_Hsap       -------RPA------RVEPTDR--------DGGEAGESSAEP-PPS-DMGTVGG-----
17822_Tthe      QNQYTQQNTMISPTYSQYNQSNSKRTS---DNFYAPQETVQSS-QQQ-------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ------------------------------------KSDLVKSGETA-TQD---V--KDV
AqueK219_Aque   -------SPN------ETLPQ---------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ---------------------ASDGSV---SSSLNPSL----------------------
WNK_d_Smoe      ---------------------CQ-------------GT----------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       -PGE----------ARLAP----ISEEGKPQLV-GRFQVTSSK-EPAEP-----------
Wnk3_Hsap       FSYE----------KLQALQETCKENKGVPKQ-GDNFLSFSAAC-ETDV-----------
C46C2.1_Cele    -------------------------QLISPSNP-DVLTTMSSAVEGSAS-----------
CG7177_Dmel     QPQQ----------IHQLPGGTSTTTSGAGTQC---IVVPQVV-NQN-------------
Wnk1_Mmus       VPDS----------THKAPTPEAKSDAGQPTKV-GRFQVTTTA-NKVGR-----------
Wnk2_Mmus       ---V----------G-SPAQLRGARDSGSPHKRPGQQDNSSPA-KTVGR-----------
Wnk3_Mmus       VSSR----------KLRTLYETFKEDKGDPEQ-GD-IVSYSTAC-ETSV-----------
Wnk4_Mmus       -LGD----------ARLAP----ISEEGKPQLV-GRFQVTSSK-EPAEP-----------
Wnk1_Hsap       VPES----------AHKTTASEAKSDTGQPTKV-GRFQVTTTA-NKVGR-----------
Wnk2_Hsap       ---Q----------A-SHPQTLGARALGSPRKRPEQQDVSSPA-KTVGR-----------
17822_Tthe      -----------------------------------------------------QSLSNVI
8961_Tthe       ------------------------------------------------------------
WNK_Spur        VSDLVSQTEKNIDKEGADVAETAKPSAGSPVKL-SRFQVNKVS-DKTSVVEGKTSAEQSV
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ---LP--------------------LQP-----------------TSP-TLSG--S-PK-
Wnk3_Hsap       ---SS--------------------VT-PEKEFEETSATGSSMQSGSE-LLLK-------
C46C2.1_Cele    ---ST--------------------MIEDIDAS--TSAVDASMMNSMP-PGAQNSTDQI-
CG7177_Dmel     -----------------------------------------GTHVQQPSNLQP--Q-QQ-
Wnk1_Mmus       ---FS--------------------VSRTEDKV--TELKKEG-PVTSP-PFRD--S-EQ-
Wnk2_Mmus       ---FS--------------------VVSTQDEW--TLASPHSLRYSAP-PDVY--LDEI-
Wnk3_Mmus       ---SS--------------------VA-TEKNV--TSTTEVSVQSGSE-PLDK-------
Wnk4_Mmus       ----P--------------------LQP-----------------ASP-TLSR--S-LK-
Wnk1_Hsap       ---FS--------------------VSKTEDKI--TDTKKEG-PVASP-PFMD--L-EQ-
Wnk2_Hsap       ---FS--------------------VVSTQDEW--TLASPHSLRYSAP-PDVY--LDEA-
17822_Tthe      PSVATNQTNQQQQNQKLSQTPQ-QNLQSKQEEL--SAEQLNQQFY---------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        PETAS--------------------IETNKDDQ--TDIEKQP-EAEQP-PLP--------
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------EYPELVS-----------------------------------
WNK_a_Smoe      ---SAVEEPPEQDPASFNKLVELRRSDS-------------SQDH-------------AY
WNK_d_Smoe      ---FCLDVKTEQTPTNLLKIVEHQN-----------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------KRPEHAG-----------------------------------
WNK_b-1_Smoe    ------------------KRPEHAS-----------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------PSTPQ-L-----------------------------------------TSESSD
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------PAAMT-LSMDQECAQSMTSSITRNTTGTKLATFENLETALSSTLGTH-IRQ-PN
CG7177_Dmel     ------SVHPN-M-------------------------------------TQQPQQTPLN
Wnk1_Mmus       ------TVIPA-V-------------------------------------IPK-KEKPEL
Wnk2_Mmus       ------PSSPE-VKLAVRRVQ----------------------TA--SSIEVG-VEE-PA
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------LPSPP-L-----------------------------------------TSESSD
Wnk1_Hsap       ------AVLPA-V-------------------------------------IPK-KEKPEL
Wnk2_Hsap       ------PSSPD-VKLAVRRAQ----------------------TA--SSIEVG-VGE-PV
17822_Tthe      -QSLLSPNSQQVIKFQLQEQSN---------------------NA--PTPMVN-KQQ-LQ
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ---------------------SATASLAI----------------------KE-ADREPS
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      SW----------EGIAVEREQT--------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       TEDSAGGGPE--------TREALAE------------S---DRAAEGLGAGVEEEGDDG-
Wnk3_Hsap       -----------------------EREI-LTAGKQP-SS-DSEFSASLAGSGKSVAKTGP-
C46C2.1_Cele    APS------------------------------------------------SRDETTAP-
CG7177_Dmel     GHPSMVNT------------------------------LQQQP-----------------
Wnk1_Mmus       AEPSHLNGPS---------------------------S---DLEAAFLSRGTEDGSGSP-
Wnk2_Mmus       SSDSGDERPR--------RRSQVQKQS-SLPGTGGVASDFVKKATAFLHRSSRAGSLGP-
Wnk3_Mmus       -----------------------EKNE-STPGKQT-C--TNEFSATLAGNRKSVTKTRP-
Wnk4_Mmus       TEDSAAGGPE--------TREALAE------------S---DRAAEGLGVAVDDEKDEG-
Wnk1_Hsap       SEPSHLNGPS---------------------------S---DPEAAFLSRDVDDGSGSP-
Wnk2_Hsap       SSDSGDEGPR--------ARPPVQKQA-SLPVSGSVAGDFVKKATAFLQRPSRAGSLGP-
17822_Tthe      NQQLQQQQTQ--------QQSQQQQQQ-QQNYQSVI------------------------
8961_Tthe       ASSNATQTLN--------QNSQGYNQA-HIPITPQH------------------------
WNK_Spur        PHPQQGNEPAVDISVGPAIKP--ERKS-SLIG------SERDTPDSIASDGSSLPSFPP-
AqueK219_Aque   ---SDDETDG--------ERQQLLREITRIEEEEKRLKKDKERYQAHLRRGSAITHEYTN
WNK_e_Smoe      ---------------------SS-------------------------------------
WNK_a_Smoe      ---------------------LVVE-----------------------------------
WNK_d_Smoe      ---------------------VDS--------D---------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ---------------------AVPE-------E---------------------------
WNK_b-1_Smoe    ---------------------AVPE-----------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       KE----PQ-V--------GGSPQPLSH-------PSPVWM-N-------YSYSSLCLSSE
Wnk3_Hsap       ESNQCLPHHE--------EQA-YA----------QTQSSL-F-------YSPSS-PM-SS
C46C2.1_Cele    MT----PSFTNERIGGGGGGGA-TSF----------SIGT-P-------PSHSPFPVSEC
CG7177_Dmel     ------------------PQQSLPMQ----------------------------------
Wnk1_Mmus       HS----PPHL--------CSKSLPVQN-------LSQSLS-N-------SFNSS-YM-SS
Wnk2_Mmus       ET----PSRA--------GVK-VPTI----------SITS-F-------HSQSS-YI-SS
Wnk3_Mmus       EGDQYLPLRE--------EQA-YA----------QTQNSL-F-------YSPSS-PM-SS
Wnk4_Mmus       KE----PL-L--------GGSSPILSH-------PSPVWM-N-------YSYSSLCLSSE
Wnk1_Hsap       HS----PHQL--------SSKSLPSQN-------LSQSLS-N-------SFNSS-YM-SS
Wnk2_Hsap       ET----PSRV--------GMK-VPTI----------SVTS-F-------HSQSS-YI-SS
17822_Tthe      ------------------------AQN-------NQQSQV-NSIQPQVIYSNQQ-QQ-NS
8961_Tthe       ------------------------SKD----------------------HAQQN-YI-KS
WNK_Spur        EG----PTLQ--------QSAGLPGQPFGPGQGVFAQPESQS-------TPPLS-DV-GS
AqueK219_Aque   VM----PKTS--------AVT-YPTHH-------VTSTSS-A-------MLSSA-SL-GP
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ---------------------------------------------SSSC----G--G-VT
WNK_d_Smoe      ---------------------------------------------GAGC---------NE
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ---------------------------------------------GSSC---------EE
WNK_b-1_Smoe    ---------------------------------------------GSSC---------EE
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       -------------------------------------------------ESESS-G----
Wnk3_Hsap       -------------------------------------------------DDESE-I----
C46C2.1_Cele    ---------------------------------------------DYDLKGQMD-L----
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       -------------------------------------------------DNESD-I----
Wnk2_Mmus       -------------------------------------------------DNDSE-F----
Wnk3_Mmus       -------------------------------------------------DNESE-I----
Wnk4_Mmus       -------------------------------------------------ESESS-G----
Wnk1_Hsap       -------------------------------------------------DNESD-I----
Wnk2_Hsap       -------------------------------------------------DNDSE-L----
17822_Tthe      -------------------------------------------------NNLN---AQ--
8961_Tthe       -------------------------------------------------ET------P--
WNK_Spur        -------------------------------------------------ASPGP-I-ANA
AqueK219_Aque   -------------------------------------------------KDERE-Q----
WNK_e_Smoe      ---------TSKQDMVAQW------------------INSTSGTF--H-EGLKHGEVV--
WNK_a_Smoe      -------------------------------------------------DLYKA-GEE--
WNK_d_Smoe      VLVTIKSSGCPEQQMVVETSEDAVSGPEGSSDIAVAAVAAATTTTVAAVTTSSA-E----
WNK_c_Smoe      -------------------------IKEE-------------------------------
WNK_b-2_Smoe    -------------------------------------------------EGSSA-G----
WNK_b-1_Smoe    -------------------------------------------------EGSSA-G----
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       -------EDEEFWAELQSLRQKH----LSEVETLQTLQKK--------------------
Wnk3_Hsap       -------EDEDLKVELQRLREKH----IQEVVNLQTQQNK--------------------
C46C2.1_Cele    -------ESED--PEVIQMIVRH----RMEQHKLLEKQRV--------------------
CG7177_Dmel     ---TIQSQQQQ-HNQMPIISQQQ----QQQIL-MQQQQQQGSQQGSQQFNLPGTQQTHPQ
Wnk1_Mmus       -------EDEDLRLELRRLREKH----LKEIQDLQSRQKH--------------------
Wnk2_Mmus       -------EDADIKKELRSLREKH----LKEISELQSQQKQ--------------------
Wnk3_Mmus       -------EDEDLKVELQRLREKH----IQEVVSLQTQQNK--------------------
Wnk4_Mmus       -------EDEEFWAELQNLRQKH----LSEVEALQTLQKK--------------------
Wnk1_Hsap       -------EDEDLKLELRRLRDKH----LKEIQDLQSRQKH--------------------
Wnk2_Hsap       -------EDADIKKELQSLREKH----LKEISELQSQQKQ--------------------
17822_Tthe      -------QQQQQQLQQQQLQQQQ----QQQL--LQQQQQQ--------------------
8961_Tthe       -------EICQLQKPLTKLTKKQICMQRMSM--INSNSDL--------------------
WNK_Spur        DLGQVQPSQAEAARELQELLKRQ----DEERAKILHRHRS--------------------
AqueK219_Aque   -------QQQQQQQQQQQQQQQS----LQQQLHYQQQQQ---------------------
WNK_e_Smoe      -------NPEQREQQHQVLASEE----QQQ-----EQQQE--------------------
WNK_a_Smoe      -------DGEEMAHEMVLLMLKQ----EEEIKELQKRHEQ--------------------
WNK_d_Smoe      -------QDESIARELKLLALRQ----EQELRELQRKHES--------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    -------IDDPLEWEMAVLAHKQ----EQELRQLRRQHEQ--------------------
WNK_b-1_Smoe    -------IDDPLEWEMAVLAHKQ----EQELRQLRRQHEQ--------------------
GK075_Glam      -----------------NVGLYR-----EELL-VR-------------------------


Wnk4_Hsap       --EIEDLYSRLGKQPP--------------------------------------------
Wnk3_Hsap       --ELQELYERLRSIKD--------------------------------------------
C46C2.1_Cele    --EIERLRSKIRVP-RA-------------------------------------------
CG7177_Dmel     HQFIQSQPNQLHSLP-P-------------------------------------------
Wnk1_Mmus       --EIESLYTKLGKVPP--------------------------------------------
Wnk2_Mmus       --EIEALYRRLGKPLPP-------------------------------------------
Wnk3_Mmus       --ELQELYERLRATKD--------------------------------------------
Wnk4_Mmus       --EIEDLYSRLGKQPP--------------------------------------------
Wnk1_Hsap       --EIESLYTKLGKVPP--------------------------------------------
Wnk2_Hsap       --EIEALYRRLGKPLPP-------------------------------------------
17822_Tthe      --QLQQ--SQQQQQ----------------------------------------------
8961_Tthe       --SCQE--IGQH------------------------------------------------
WNK_Spur        --EMQEFIAHYPQTTPP-------------------------------------------
AqueK219_Aque   -----QLHQHLN------------------------------------------------
WNK_e_Smoe      --QLLKAE---REDDGI-------------------------------------------
WNK_a_Smoe      --ALFM------------------------------------------------------
WNK_d_Smoe      --ALLEIRNRCRCKRSSSLSSPQSSPHNQNMDSLSRLLDTDFDLQQLVASQAVDTAAQEA
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    --AVLELRDRYKQKPG--------------------------------------------
WNK_b-1_Smoe    --AVLELRDRYKQKPG--------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       ------------------------------------------------------------
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ------------------------------------------------------------
Wnk2_Hsap       ------------------------------------------------------------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ------------------------------------------------------------
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      -------NTSVTDMHTSSVGDSVSEATVSEVSGAKLEDGF----------DNTSVVGGPR
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      LPFDCDAGETSTAYRISTAGTSSSP-STSLSAVCKPDEGFCFFDQERAVEDHHRPPSSPS
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       ------------------------------------------------------------
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ------------------------------------------------------------
Wnk2_Hsap       ------------------------------------------------------------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ------------------------------------------------------------
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ---------------------------------------------------ERECVPGEL
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      SASCSNDCFADLVDIAKATSLAPELERTLKPAGTWPECSFLSQQDATGRKENGLCEPGAL
WNK_c_Smoe      ----------------------------------------------------PSCRP---
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       --------------------------PGIV---------A--------------------
Wnk3_Hsap       --------------------------SKTQ---STE---I--------------------
C46C2.1_Cele    ---------------------------TSV---------N--------------------
CG7177_Dmel     --------------------------QVVS---------M--------------------
Wnk1_Mmus       --------------------------AVII---------P--------------------
Wnk2_Mmus       --------------------------NVGF---------F--------------------
Wnk3_Mmus       --------------------------NKAQ---SSE---V--------------------
Wnk4_Mmus       --------------------------PGIV---------A--------------------
Wnk1_Hsap       --------------------------AVII---------P--------------------
Wnk2_Hsap       --------------------------NVGF---------F--------------------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        --------------------------QS--------------------------------
AqueK219_Aque   -----------------------------Y---------Y--------------------
WNK_e_Smoe      ----------------------CE----ISVNRMDCAVVEAATPQ---------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      RYETLFDGSERFVDATCSERPSSEMVGEFSGR----EAVEPGKQQQGSLEQRQALRIGGG
WNK_c_Smoe      --------------------------GRIQI-----------------------------
WNK_b-2_Smoe    --------------------------MRFCGR----PSLE--------------------
WNK_b-1_Smoe    --------------------------MRFCGR----PSLE--------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       --PAAMLSSRQR-----------------RLSKGSFP-TSRRNSLQR-------------
Wnk3_Hsap       --PLPPASPRRP-----------------RSFKSKLRS--RPQSLTHVDNGIVATGKSCL
C46C2.1_Cele    --PEMI--GDDE-----------------ADT----TLTALQSALGN-------------
CG7177_Dmel     --AQGNL-----------------------------------------------------
Wnk1_Mmus       --PAAPLSGRRR-----------------RPTKSKGSKSSRSSSLGN-------------
Wnk2_Mmus       --HTAPPMGRRR-----------------KTSKSKLKAGKLLNPLVQ-------------
Wnk3_Mmus       --PLSPASPRRP-----------------RSFKSKLRS--RPQSMTHSDNLVVK------
Wnk4_Mmus       --PAAMLSCRQR-----------------RLSKGSFP-TSRRNSLQR-------------
Wnk1_Hsap       --PAAPLSGRRR-----------------RPTKSKGSKSSRSSSLGN-------------
Wnk2_Hsap       --HTAPPTGRRR-----------------KTSKSKLKAGKLLNPLVR-------------
17822_Tthe      -----------I-----------------QQQQQQLN-QN---NILS-------------
8961_Tthe       -----------H-----------------HDKKESAN-KS---QFQQ-------------
WNK_Spur        -----PLLLYQPNMYSMVPFPMQENFAPPGNFAPQGNF--APQGMWHPSSNLIPYNHFQG
AqueK219_Aque   --SIGSSTGQRP-----------------GYHPF--------------------------
WNK_e_Smoe      -----------------------------------PG-TG---LYRY-------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ICERD--KASSR-----------------GVERSATT-SS---VLVH-------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    --ELA--MCDDR-----------------GDKRQSFG-SS---EFQF-------------
WNK_b-1_Smoe    --ELA--MCDDR-----------------GDKRQSFG-SS---EFQF-------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       --S---------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    --A----SLS--------------LPAS-PPPNT----------ETTKVNT--T------
CG7177_Dmel     -------------------------PHQ-LPPMQTMG------AQ--QQMISQQ------
Wnk1_Mmus       --K----SPQL---SGNLSGQSGT-SVL-HPQQTLH---PAGNTPETGHNQ--L------
Wnk2_Mmus       --Q----LKVVASSTGHLSDSSRGPPTK-DPAHAS-------TPPGTKAVQ--T------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       --S---------------------------------------------------------
Wnk1_Hsap       --K----SPQL---SGNLSGQSAA-SVL-HPQQTLH---PPGNIPESGQNQ--L------
Wnk2_Hsap       --Q----LKVVASSTGHLADSSRGPPAK-DPAQASVGLTADSTGLSGKAVQ--T------
17822_Tthe      --QNIPQT------Q-------------------------------------------NV
8961_Tthe       --GILPQL------AQSESRDSSQ-SQAQQQMQQSY---PQPNYSHVNQNQ--MQNQQFT
WNK_Spur        VPF----THAPGSAFGGFRQGTTSPPTV--PGMSSMG------VPVQGGMV--T------
AqueK219_Aque   ------------------HYYQGGPPLH-PPPHDTRD---------NGSLL--S------
WNK_e_Smoe      --SP-K------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      --HKQA------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    --KEVP------------------------------------------------------
WNK_b-1_Smoe    --KEVQ------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       -----INEL--E------------------------------------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     -----QHQLQMQSHMH-QQNVPGMYNQQTGARVAA-------------------------
Wnk1_Mmus       -----LQPL--KPSPSSDNLYSAFTSDGAI------------------------------
Wnk2_Mmus       -----QQPCSVRASLS-TDICSGLASDGGGARGQGWTVYHPTSE----------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       -----LQPL--KPSPSSDNLYSAFTSDGAI------------------------------
Wnk2_Hsap       -----QQPCSVRASLS-SDICSGLASDGGGARGQGWTVYHPTSE----------------
17822_Tthe      Q--QII-------EVQ-TQFIQ-SQS----------------------------------
8961_Tthe       QQIQTQ-------EIN-QLICNNVTQ----------------------------------
WNK_Spur        -----YRPVAGVEMPG-QGAMPGAAPAMTGAQYQVPTTMHPRFSASNEMIPQQTYTNSQG
AqueK219_Aque   -----QQNNSSTSNLA-AAAAAGEASRHI-EAGRG-TPYYPTAP----------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       --------------EPP--GP---------GI---------------M------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    --------------VIP--SD---------VL---------------A------------
CG7177_Dmel     ---PQNFAGAVP--------------------NHLLQQSPLMASQQPAQP--MQHVMQPI
Wnk1_Mmus       ---------SVPSLSAP--GQ---------GT---------------S------------
Wnk2_Mmus       -------RGAYKSSSKP--RA---------RF---------------L------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       --------------DLP--GP---------GI---------------M------------
Wnk1_Hsap       ---------SVPSLSAP--GQ---------GT---------------S------------
Wnk2_Hsap       -------RVTYKSSSKP--RA---------RF---------------L------------
17822_Tthe      ----------------P--PPQIGQQK---IQ---------------Q------------
8961_Tthe       ----------------HHQNSHHSHSL---II---------------Q------------
WNK_Spur        LKRSVSYQ-----SVVP--QP---------N-----TGFQPAFFPNPNQPMGPPNPEAFM
AqueK219_Aque   -------IGPHSHIMPQ--EG---------LHLMAPGGMWLPPSDWPQ------------
WNK_e_Smoe      -------------------APETDN-----DI---------------L------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      -------------------CSEGEIGLTTLEQ---------------Q------------
WNK_c_Smoe      --------------------------KAALEA---------------I------------
WNK_b-2_Smoe    -------------------ASKTSCGL---DV---------------Q------------
WNK_b-1_Smoe    -------------------ASKTSCGL---DV---------------Q------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       ------------------------------------------------------------
Wnk2_Mmus       SGP---------------------------------------------------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ------------------------------------------------------------
Wnk2_Hsap       SGP---------------------------------------------------------
17822_Tthe      ------------------------------------------------------------
8961_Tthe       ------------------------------------------------------------
WNK_Spur        PRPGAGNAWMSSAGGAMQIMDMKDQQSIQNGINRSPEQLPRGIDNAGVTFPTQQVHPYPS
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------RR----------------
Wnk3_Hsap       ------------------------------------------------------------
C46C2.1_Cele    ------------------------------------------TR----------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       ------------------------------------------ST----------------
Wnk2_Mmus       ---------------------------------VSVSI--SLKR----------------
Wnk3_Mmus       ------------------------------------------------------------
Wnk4_Mmus       ------------------------------------------RR----------------
Wnk1_Hsap       ------------------------------------------ST----------------
Wnk2_Hsap       ---------------------------------VSVSIWSALKR----------------
17822_Tthe      ------------------------------------------Q-----------------
8961_Tthe       ------------------------------------------R-----------------
WNK_Spur        HVRTGSGTEKIDFTKRMVPMNSEATEAVTSKGYQA--------QTDLGQVERRLEEARPG
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      ------------------------------------------KK----------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------RK----------------
WNK_c_Smoe      ------------------------------------------RR----------------
WNK_b-2_Smoe    ------------------------------------------R-----------------
WNK_b-1_Smoe    ------------------------------------------R-----------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       --------------------------------------------N-----SLS------G
Wnk3_Hsap       --------------------------------------------N-----PLCV------
C46C2.1_Cele    --------------------------------------------M-----TMS------Q
CG7177_Dmel     -------------------------------------------FN-----ATS------G
Wnk1_Mmus       --------------------------------------------N-----TVG------G
Wnk2_Mmus       --------------------------------------------L-----CLGKEHSSRS
Wnk3_Mmus       --------------------------------------------D-----ALGV------
Wnk4_Mmus       --------------------------------------------N-----SLS------G
Wnk1_Hsap       --------------------------------------------N-----TVG------A
Wnk2_Hsap       --------------------------------------------L-----CLGKEHSSRS
17822_Tthe      -----------------------------------------------QFTQNER-----V
8961_Tthe       -----------------------------------------------SQPNQQ------T
WNK_Spur        GLSQPNYQSENTELHGQIDNRVAVDHPTTDPRPADNNTDVIPTDQ-----TVA------A
AqueK219_Aque   ------------------------------------------------------------
WNK_e_Smoe      --------------------------------------------EK-LQRSIA------E
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      --------------------------------------------EQLLQKSIA------E
WNK_c_Smoe      --------------------------------------------EFLSG-----------
WNK_b-2_Smoe    -----------------------------------------------RQKSMS------D
WNK_b-1_Smoe    -----------------------------------------------RQKSMS------D
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       S--S-------------TGSQEQ----RASKGVT--------------------------
Wnk3_Hsap       --ES-------------NAASCQ--QSPASKKGMFTDDLHKLVDDWTKEAVGNS---LIK
C46C2.1_Cele    S--S-------------TKSSNVS------------------------------------
CG7177_Dmel     EVT------EEPVSL----AATHPHLLPSDIQSDIKHNLDSLVNQLCNTRLGTN---QHQ
Wnk1_Mmus       TVSS-------------QAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLS---GRR
Wnk2_Mmus       STSSLAP-GPEPGPQPTLHVQAQ-VNNSNNKKGTFTDDLHKLVDEWTTKTVGAA---QVK
Wnk3_Mmus       --ES-------------NTVSCQ--QSPASKKGMFTDDLHKLVDDWTRETVGHF---PSK
Wnk4_Mmus       S--S-------------TGSQEQ----RASKGVT--------------------------
Wnk1_Hsap       TVNS-------------QAAQAQPPAMTSSRKGTFTDDLHKLVDNWARDAMNLS---GRR
Wnk2_Hsap       STSSLAP-GPEPGPQPALHVQAQ-VNNSNNKKGTFTDDLHKLVDEWTSKTVGAA---QLK
17822_Tthe      V--Q-------------QQQ------ATAQVQQKLIQNNQQLIQ-NSQA-QQLT----QQ
8961_Tthe       I--S-------------LNQNM---SIDNSQKGYLINNNQETNQ-ALQNICNLS----QQ
WNK_Spur        QLQT-----------PA--SQQQQQQQAGKRKGTFADDKFKNLADLSKPTAARPALDERK
AqueK219_Aque   -----YMHP------------HVPPAHFSSTNQAMMQGLHHSITPH--------------
WNK_e_Smoe      L--E-------------ARTLE---GLS-KKNGYF-------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      L--E-------------AKTLE---GLHHSRNGYLVSSKKA-------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    M--D-------------VKKSL---ALEA-------------------------------
WNK_b-1_Smoe    M--D-------------VKKSL---ALEA-------------------------------
GK075_Glam      ------------------------------------------------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ---------------PSLNQ---LKQSQHKLETEN-W----------NKVS---------
C46C2.1_Cele    ------------------------------------------------------------
CG7177_Dmel     ---------------R-LLL---LRQRQLIEEDEL-RLKHYVEYEKFQKA----------
Wnk1_Mmus       ---------------GSKGH---M-------NYE-----------GPGMAR---------
Wnk2_Mmus       ---------------PTLNQ---LKQTQKLHDMEA-S----------GDAR---------
Wnk3_Mmus       ---------------PSLNQ---LKQSQQKSEAEN-W----------NKSC---------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ---------------GSKGH---M-------NYE-----------GPGMAR---------
Wnk2_Hsap       ---------------PTLNQ---LKQTQKLQDMEA-Q----AGWAAPGEAR---------
17822_Tthe      ASNQQQQQQQN-QQTLSINQQNLQQQQQIQQQQLNNN----------NNNINMQQQPQQQ
8961_Tthe       SSQSAQNDQSPMNQFLSFNP---IQNKQVNQEAQN-Q----------NNNSASRL-----
WNK_Spur        ---------------VSLND---LKRAQQQQDLH--------------------------
AqueK219_Aque   -----------------------------------------ITHPPPPLSS---------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      AS----------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      -----------------LQQ---FLDENM------------IDKSVVDPA----------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       -------------------------ENTPSTMGYTSTWISSLSQIRGAVPTSLPQ-----
C46C2.1_Cele    --------------------------------------VSSRHRDNQSAPPRHHH-----
CG7177_Dmel     ------------------------------------LRQSISTNV----PANAAY-----
Wnk1_Mmus       ------------------------KFSAPG---Q--LCVPMTSNLGGSTPISAAS-----
Wnk2_Mmus       ------------------------ATSVP---------------------RAAVG-----
Wnk3_Mmus       -------------------------ESTPSTMGYTSNWISSLSQIRGAAPTSLPQ-----
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ------------------------KFSAPG---Q--LCISMTSNLGGSAPISAAS-----
Wnk2_Hsap       ------------------------AMTAP---------------------RAGVG-----
17822_Tthe      QQTMLGQNTQVTNVNQQQQYQLQNQVQQQMTNQ--TNVQTNNANIQRSSPIKIEDEIKKI
8961_Tthe       -------------------------------------------NLQIIENTN--------
WNK_Spur        ------------------------------------------------------------
AqueK219_Aque   ------------------------------------------------------H-----
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------LDK---------------------


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       ----------------------------GLSLPSFPG---PLSSYGMPHVC-------QY
C46C2.1_Cele    ----------------------------HQPHPPHH---PHLQNHYHP--P-------QN
CG7177_Dmel     ----------------------------YSA---AAA---QLPTN---LAAPAAPS----
Wnk1_Mmus       ----------------------------ATSLGHFTKSMCPPQQYGFP------------
Wnk2_Mmus       ----------------------------ASCLAPAPG---PLSTTATPGATPALPVP---
Wnk3_Mmus       ----------------------------GLPLPSFHG---PLASYGMPHVC-------QY
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ----------------------------ATSLGHFTKSMCPPQQYGFP------------
Wnk2_Hsap       ----------------------------MPRLPPAPG---PLSTTVIPGAAPTLSVPTPD
17822_Tthe      ILEIKLKLQRPQAVKIDRVNHDKVKDENEVRLLQRSLKLCSPQEQILENG---------H
8961_Tthe       ------------------------------------------------------------
WNK_Spur        ------------------------------------------------------------
AqueK219_Aque   ----------------------------LPMQQTYPKSQQAQ----------------QE
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------------------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------------------------------
WNK_b-1_Smoe    ------------------------------------------------------------
GK075_Glam      ------------------------------------E---DAPKV---ISSDSLPAP--E


Wnk4_Hsap       ------------------------------------------------------------
Wnk3_Hsap       NAVAGAGYPVQWVGISGTTQQS---VVIPAQSGGPFQPG---------------------
C46C2.1_Cele    HTSAT-----------APCPS----------AMVQLQAVS--------------------
CG7177_Dmel     ------------------------------------------------------------
Wnk1_Mmus       ----PAPFGTQWSGTGGPAPQ----------PLGQFQPVG--------------------
Wnk2_Mmus       ------------------------------------------------------------
Wnk3_Mmus       NAVGAAGYPVQWVGISGPAQQS---VVLPTQSGGLFQPG---------------------
Wnk4_Mmus       ------------------------------------------------------------
Wnk1_Hsap       ----ATPFGAQWSGTGGPAPQ----------PLGQFQPVG--------------------
Wnk2_Hsap       GALGTARRNQVWFGLRVPPTAC---CGHSTQPRGGQRV-G--------------------
17822_Tthe      FACNGAIENDLWKSISNELENQ---L-------AQIENKANLQQQKDQNKKKLIKEIQSQ
8961_Tthe       ----------------TP----------------QFSPVPSKQ---------------NP
WNK_Spur        ------------------------------------------------------------
AqueK219_Aque   VQTYQQPQQLQQEGTLNPVVV----------PAGMTSPTR--------------------
WNK_e_Smoe      ------------------------------------------------------------
WNK_a_Smoe      ------------------------------------------------------------
WNK_d_Smoe      ------------------------------------VG----------------------
WNK_c_Smoe      ------------------------------------------------------------
WNK_b-2_Smoe    ------------------------------------MP----------------------
WNK_b-1_Smoe    ------------------------------------MP----------------------
GK075_Glam      A--------------------KVDPLGDNQN-VDEQF-----------------------


Wnk4_Hsap       ----------------------FAGDVGRM
Wnk3_Hsap       ---MNMQAFPTSSV----QN-PATIPPGPK
C46C2.1_Cele    --NNNVN-----PLHQ-PPHPVSSQIPPQA
CG7177_Dmel     -----------------SSN-PTSTSSANT
Wnk1_Mmus       --TASLQNFNISNLQKSISNP-PGSNLRTT
Wnk2_Mmus       -------------------IP-DPESEKPD
Wnk3_Mmus       ---MNLQSFPAPPV----QN-PASIPPGPK
Wnk4_Mmus       ----------------------FAGDIGRM
Wnk1_Hsap       --TASLQNFNISNLQKSISNP-PGSNLRTT
Wnk2_Hsap       ---SKT------------ASF-AASDPVRS
17822_Tthe      QSKETMNNFE----SKMFSD-FSLTNNDLN
8961_Tthe       ------HIPQ----SLNNDC-NLGTQGRNI
WNK_Spur        -------AS----AARPPSG-TTKADVPKT
AqueK219_Aque   --LEGT---------GDQ-DLTGTSVTQKR
WNK_e_Smoe      ---------------------AGLVKKAGV
WNK_a_Smoe      ------------------------VRNKSI
WNK_d_Smoe      ----------------I-NQ-QQQQQQQQP
WNK_c_Smoe      -------------------K-KENEAETSG
WNK_b-2_Smoe    ----------------RPEH-KGGHSLEVV
WNK_b-1_Smoe    ----------------IPEH-KGGHSLEVV
GK075_Glam      --TCAMQ-----E--LNGYL-MIHTDIIPE