nsy-1_Cele MSQNNKRQVQ-------------------------H--NHEMSNDVCPLPLPPRGAPPPT
Pk92B_Dmel MDTAVGDH----------------------------------------------------
MAP3K5_Mmus MGTEAGEGITFSVPPFASVGFCTIPEGGSCRRGGGAATAAEGEPSLQPLLVPP-PPPPPG
MAP3K6_Mmus MAGPC-------------------------PGAGVLERAG--------------------
MAP3K7_Mmus MEGGGGSGG----------------GGGPVPAEAP-EEAG--EPPQ--------GRLPPG
MAP3K7_Hsap MESGGGNA----------------------PAGAL-GAAS--ESPQ--------CPPPPG
MAP3K5_Hsap MSTEADEGITFSVPPFAPSGFCTIPEGGICRRGGAA-AVGEGEEHQ------L-PPPPPG
MAP3K6_Hsap MAGPC-------------------------PRSGA-ERAG--------------------
ASK_Spur ------------------------------------------------------------
AqueK224_Aque MSSKVKLQ----------------------------------------------------
nsy-1_Cele AYHA----SR------MAATSSSTNGSFEKSAIP--GNARKLHVVIVIDQKVQKNLRV--
Pk92B_Dmel ------------------------------------------------------------
MAP3K5_Mmus SFWNVESAAAPGTSCPT-TAPGSSATRGRGNSGS--GGGRRTTVAYVINEASQGQLVV--
MAP3K6_Mmus SCWQDP----------L-AEALSRGRSSPAVTGRGCARSRPLSVVYVLTREPGLGVEPGS
MAP3K7_Mmus ----PEGAAGL--AEPE-STGDAA--GGEAEGGR--GPRRALRAVYVRSESSQGAAAG-G
MAP3K7_Hsap ----VEGAAGP--AEPDGAAEGAAGGSGEGESGG--GPRRALRAVYVRSESSQGGAAG--
MAP3K5_Hsap SFWNVESAAAPGIGCPA-ATSSSSATRGRGSSVG--GGSRRTTVAYVINEASQGQLVV--
MAP3K6_Hsap SCWQDP----------L-AVALSRGRQLAAPPGRGCARSRPLSVVYVLTREPQPGLEPRE
ASK_Spur ------------------------------------------------------------
AqueK224_Aque ---------------------------------RS--VREQQVIVTVIPDT---------
nsy-1_Cele ----REMALKDVQKVADTL-----NVNLTRIDFDKLDFGETETLDLFYNADVALVDVTVT
Pk92B_Dmel -LEDRQCALEEIKQAVQSA-----GANFQRVQFERLDFGETNVLETFYNADVAIIDLSIL
MAP3K5_Mmus ---AESEALQSLREACEAV-----GATLETLHFGKLDFGETAVLDRFYNADIAVVEMSDA
MAP3K6_Mmus GTEAEPLPLRCLREACAQLQGTRPPPQLRSLPFATLALGDTAALDSFYNADVVVLEVSSS
MAP3K7_Mmus --GPEAGALKCLLRACEAE-----GAHLTSVPFGELDFGETAVLDAFYDADVAIVDMSDI
MAP3K7_Hsap --GPEAGARQCLLRACEAE-----GAHLTSVPFGELDFGETAVLDAFYDADVAVVDMSDV
MAP3K5_Hsap ---AESEALQSLREACETV-----GATLETLHFGKLDFGETTVLDRFYNADIAVVEMSDA
MAP3K6_Hsap GTEAEPLPLRCLREACAQVPRPRPPPQLRSLPFGTLELGDTAALDAFYNADVVVLEVSSS
ASK_Spur -------AEDALNNACRLVN----NVTLIKVNFDRLDFGETKVLDRFYAADIVVVDVSVI
AqueK224_Aque -REGRK-CFNVLQEVANEL-----DYIVERIAFEKLDFGETDALDKFYSSNVAVADVTDR
: .. . : * * :*:* .*: ** :::.: :::
nsy-1_Cele HQQPSLCYHIGVRESMGQSYNMILTYWSPDPEYHIMDALKK--------THAHLPMIVYI
Pk92B_Dmel TQQRPLSYHYGVRESFGMKENILTYNDIDSKQ-T--LS-----LK---LSCANYLFLSYK
MAP3K5_Mmus FRQPSLFYHLGVRESFSMANNIILYCDTNSDS-L--QSLKEIICQKNTVCTGNYTFIPYM
MAP3K6_Mmus LAQPSLFYHLGVRESFSMTNNVLLCSQAELPD-L--QALREDVFQKNSDCVGSYTLIPYV
MAP3K7_Mmus SRQPSLFYHLGVRESFDMANNVILYYDTDADT-A--LSLKDMVTQKNTASSGNYYFIPYT
MAP3K7_Hsap SRQPSLFYHLGVRESFDMANNVILYHDTDADT-A--LSLKDMVTQKNTASSGNYYFIPYI
MAP3K5_Hsap FRQPSLFYHLGVRESFSMANNIILYCDTNSDS-L--QSLKEIICQKNTMCTGNYTFVPYM
MAP3K6_Hsap LVQPSLFYHLGVRESFSMTNNVLLCSQADLPD-L--QALREDVFQKNSDCVGSYTLIPYV
ASK_Spur VQQRTLFYHMGVRESFGKEKNVVLYNDSVDPEGT--SSLMQ------SCHGSGYIFIPYK
AqueK224_Aque ACQAKLFYHLGLRESFEMKQNIVTYLESGASG-G--LR--GGAFN---PKLTSYIYLPYS
* * ** *:***: *:: : *
nsy-1_Cele HHQDSNQLQSY--DKNNNDDDSKPPFARTNVPAKTITFQHRMKQVLKSVQVEASAHSREK
Pk92B_Dmel RNAETNSCHLTSQP-NS-GNNSKEPNAE----GRVPTLQWRLKRKLQDVEIQSKAHMREK
MAP3K5_Mmus VTPHNKVYCCDSSFMKGLTEL-MQPNFELLLGPICLPLVDRFVQLLKVAQASSSQYFRES
MAP3K6_Mmus VTATGRVLCGDAGLLRGIADGLVQAGAG--TEALLTPLVGRLVRLLEATPTDSCGYFRET
MAP3K7_Mmus VTPCADYFCCESDAQRRASEY-MQPNWDTILGPLCMPLVDRFTSLLKDIRVTSCAYYKET
MAP3K7_Hsap VTPCADYFCCESDAQRRASEY-MQPNWDNILGPLCMPLVDRFISLLKDIHVTSCVYYKET
MAP3K5_Hsap ITPHNKVYCCDSSFMKGLTEL-MQPNFELLLGPICLPLVDRFIQLLKVAQASSSQYFRES
MAP3K6_Hsap VTATGRVLCGDAGLLRGLADGLVQAGVG--TEALLTPLVGRLARLLEATPTDSCGYFRET
ASK_Spur MDSKSQCYVCDMACVFKAGQL-CEED-----SALCPLLTDRLRETIEEVHISNRSNATEV
AqueK224_Aque VDSDGKCLVLDGKN----GDG-FKPK------GSNMSLEVKFRTLLRDMETQYKKQHKEQ
: : :: :. *
nsy-1_Cele FMSDLRKAREIT--DGDQKNDYLDKMRTRLDN-PDVLHPDTVSLMMLSYRDNQNYGGMIR
Pk92B_Dmel FLSDMRTARDTYATNGAKLQSILHEMRKRLDD-PHVLSGEVVHSFMCSLRDVQDYDAMVR
MAP3K5_Mmus ILSDIRKARNLY--TGKELAAELARIRQRVDN-IEVLTADIVINLLLSYRDIQDYDSIVK
MAP3K6_Mmus IRQDIRQARERF--SGQQLRQELARLQRRLDS-VELLSPDIVMNLLLSYRDVQDYSAIIE
MAP3K7_Mmus LLNDIRKAREKY--QGDELAKELTRIKFRMDN-IEVLTSDIIINLLLSYRDIQDYDAMVK
MAP3K7_Hsap LLNDIRKAREKY--QGEELAKELARIKLRMDN-TEVLTSDIIINLLLSYRDIQDYDAMVK
MAP3K5_Hsap ILNDIRKARNLY--TGKELAAELARIRQRVDN-IEVLTADIVINLLLSYRDIQDYDSIVK
MAP3K6_Hsap IRRDIRQARERF--SGPQLRQELARLQRRLDS-VELLSPDIIMNLLLSYRDVQDYSAIIE
ASK_Spur LLNDIRKARIKL--KGETLAKELGNLKARMDE-QLLLSGDIVHQFLLSYREIQDYNSMVS
AqueK224_Aque FLRQLRKARESL--KGSELKEELLRLQSWIDEDPRLFTADILLSLLLSYRDIQAYENMVL
: ::* ** * * .:: :*. :: : : :: * *: * * ::
nsy-1_Cele LVDDLKRIPDCLKVVDTPVIRYQYAFALNRRNKDGDRDLALNTVLSLVEGTTENEEKNGP
Pk92B_Dmel LVNDLKNIPNTRKYVETGNMSFLYAFALNRRNRKGDREKALESSLKALEK-------KEN
MAP3K5_Mmus LVETLEKLPTF-DLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQS-------EEQ
MAP3K6_Mmus LVETLQALPTC-DVAEQHNVCFHYTFALNRRNRPGDREKALAVLLPLVKY-------EGP
MAP3K7_Mmus LVETLKMLPTC-DLADQHNIKFHYAFALNRRNSTGDREKALQVMLQVLQS-------CDH
MAP3K7_Hsap LVETLEMLPTC-DLADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQS-------CDH
MAP3K5_Hsap LVETLEKLPTF-DLASHHHVKFHYAFALNRRNLPGDRAKALDIMIPMVQS-------EGQ
MAP3K6_Hsap LVETLQALPTC-DVAEQHNVCFHYTFALNRRNRPGDRAKALSVLLPLVQL-------EGS
ASK_Spur LVEAIKQLKND-HVTDKPAILHLYAFALNRRKKPGDREKAVTVITKALES-------DDN
AqueK224_Aque LAE---KLPSH-EQALKAPVQVQYAFALNRRNKEGDRDHALSVLEKLLEV-------KEN
*.: : . . : *:******: *** *: ::
nsy-1_Cele LSPDVVCLAGRIYKDKFIASNYEDRESLNSAIEWYRRAFEMSPLEYSGINLTTLLRASGE
Pk92B_Dmel HFPDMLCLCGRIYKDIFVESDYTDATSLAHAIKWYRQSFEVQPNEYAGINLATLLVIEGK
MAP3K5_Mmus VASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGH
MAP3K6_Mmus VAPDLYCMCGRIYKDMFFTSGFQNAGHLEQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQ
MAP3K7_Mmus PAPDMFCLCGRIYKDIFLDSGCEEDASRDSAIEWYRKGFELQSSLYSGINLAVLLIVSGQ
MAP3K7_Hsap PGPDMFCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQ
MAP3K5_Hsap VASDMYCLVGRIYKDMFLDSNFTDTESRDHGASWFKKAFESEPTLQSGINYAVLLLAAGH
MAP3K6_Hsap VAPDLYCMCGRIYKDMFFSSGFQDAGHREQAYHWYRKAFDVEPSLHSGINAAVLLIAAGQ
ASK_Spur QVPDMFCLCGRIYKDIYTESNYLDFESRDNAIYWYRKGFEVQPNEYAGINLATLLVLAGK
AqueK224_Aque HEPDTLCLCGRIYKDKFVESGHTDTGSRDKAILWYRKGFDIQPNEYAGINLATLLVVSGE
.* *: ****** : *. : . *:::.*: .. :*** :.** *.
nsy-1_Cele HFENNLEMQQIAVVLNSLLGRKGALQNLMEYWDVATYFEVSVLAENYQKACEAALMMVKL
Pk92B_Dmel EFTNTEELQHIGMTLNNLIGKKGSLSSLSEYWDVATFFEISVLANDYAKAIQAAECMFKL
MAP3K5_Mmus QFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHLRVIQASEKLFRL
MAP3K6_Mmus HFEDSEELRLIGMKLACLLARKGCVEKMQYYWDVGFYLGAQILANDPIQVVLAAEQLYKL
MAP3K7_Mmus QFETSMELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFTVSMLASDIGKAVQAAERLFKL
MAP3K7_Hsap QFETSLELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFSVSMLAHDVGKAVQAAERLFKL
MAP3K5_Hsap QFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLANDHMRVIQASEKLFKL
MAP3K6_Hsap HFEDSKELRLIGMKLGCLLARKGCVEKMQYYWDVGFYLGAQILANDPTQVVLAAEQLYKL
ASK_Spur EFTKCAELQKIGMTLNNLLGKKGSLVSLEDYWDVATFFEISVLAGDFSKASQAAECMFKL
AqueK224_Aque KFENSAELRSIAMTLNLLIGRKGNLDSQTDYWTVATFFEISVLAEDYQKASHAAECMFKL
.* *:: :.: * *:.:** : . ** *. :: .:** : :. *: : :*
nsy-1_Cele KPPVW-------YLKSTMENIKLINRCAATISPI--EKEKQQFLFWSEFFMEATEADT--
Pk92B_Dmel KPPNW-------YLKSTIGNISLIHRFRKKPEERQPPIEEQVFQFWMDFFLEATNTEE--
MAP3K5_Mmus KTPAW-------YLKSIVETILIYKHFVKLTTEQP-SAKQELVDFWMDFLVEATKTDV--
MAP3K6_Mmus NAPIW-------YLVSVMETFLLYQHFRPTPE-PS-GGPPLRAHFWLHFLLQSCQPFKMA
MAP3K7_Mmus KPPVW-------YLRSLVQNLLLIQRFKKPITEH--SPRQERLNFWLDIIFEATNEVT--
MAP3K7_Hsap KPPVW-------YLRSLVQNLLLIRRFKKTIIEH--SPRQERLNFWLDIIFEATNEVT--
MAP3K5_Hsap KTPAW-------YLKSIVETILIYKHFVKLTTEQP-VAKQELVDFWMDFLVEATKTDV--
MAP3K6_Hsap NAPIW-------YLVSVMETFLLYQHFRPTPE-PP-GGPPRRAHFWLHFLLQSCQPFKTA
ASK_Spur KPPIW-------YLKSTLGNIQMICRVRPTSDEEP-TIDQQLFNFWLDFFVEATKEST--
AqueK224_Aque RPPYWLYTYTYRYLKSTISNIQLISQFRVTSEDAPMSQEAKVFEFWMEFLIEATKD----
..* * ** * : .: : : ** .::.:: :
nsy-1_Cele DISCPRYPVLILELNK------EFTPSYLTLNN--E--EGT--VILSHVLENSQQKKIHQ
Pk92B_Dmel VKNSIRFPILILEPQK------IYMPSYVTINMDA--DEKS--IQIVNICLAH-----AK
MAP3K5_Mmus --TVVRFPVLILEPTK------IYQPSYLSINNEV--EEKT--ISIWHV---L------P
MAP3K6_Mmus PPQEDQCLVLVLEINK------VLLPARLEIQGTD--PVST--VTLSLL---D------P
MAP3K7_Mmus --NGLRFPVLVIEPTK------VYQPSYVSINNEA--EERT--VSLWHV---S------P
MAP3K7_Hsap --NGLRFPVLVIEPTK------VYQPSYVSINNEA--EERT--VSLWHV---S------P
MAP3K5_Hsap --TVVRFPVLILEPTK------IYQPSYLSINNEV--EEKT--ISIWHV---L------P
MAP3K6_Hsap CAQGDQCLVLVLEMNK------VLLPAKLEVRGTD--PVST--VTLSLL---E------P
ASK_Spur --TDLRFPVLVLEPSK------IYKPSYITISEGDETQERS--IRLWHV---G-----LE
AqueK224_Aque QYSNSQFPILLFEPNPQNVSEYQYIPSYIALHEAS--SSSTAKIEIWYQ---M-----SD
: :*::* *: : : : : :
nsy-1_Cele SELRGIHRWHFARNNIKAVTESKRDDRQLFLYVHEN-SDDFNLLFPTKAHCKKAYDDMKS
Pk92B_Dmel NACKKIHDFLFVASKIKSVSLYKRDDRCAYLYVHHN-SDDFQIYFPSTERRQKFYDMILE
MAP3K5_Mmus DDKKGIHEWNFGASSVRGVSISKFEERCCFLYVLHN-SDDFQIYFCTELHCKRFFEMVNT
MAP3K6_Mmus ETQEDPSSWTFPVTSICGISTSKLDQRCCFLYALPP-AQDVQLCFPSVERCQRFCGLIQV
MAP3K7_Mmus TEMKQIHEWNFTASSIKGISLSKFDERCCFLYVHDN-SDDFQIYFSTEDQCNRFCSLVKE
MAP3K7_Hsap TEMKQMHEWNFTASSIKGISLSKFDERCCFLYVHDN-SDDFQIYFSTEEQCSRFFSLVKE
MAP3K5_Hsap DDKKGIHEWNFSASSVRGVSISKFEERCCFLYVLHN-SDDFQIYFCTELHCKKFFEMVNT
MAP3K6_Hsap ETQDIPSSWTFPVASICGVSASKRDERCCFLYALPP-AQDVQLCFPSVGHCQWFCGLIQA
ASK_Spur KNSREISEWLFNLSSIKGVSTYKRDDRCLFLYVQQN-ADDFQLFYPSSSQRQRFHDLIMD
AqueK224_Aque EDDVVVSEWAYEIACVRNVSIIKRDNRGLFLYVLDKYSDDFQMFFSSELQCSKVFQLILS
: : : :: * ::* :**. ::*.:: : : : . :
nsy-1_Cele MADVAD----GN-YQGRVLSNPDNEKIRFEYELSNSNERVVLGKGTYGTVYAARDMDTQR
Pk92B_Dmel MTADQV-------VFVN-LS-NDDANIEYEYDYDEQNRKMVLGKGTYGTVYAARDKQTQV
MAP3K5_Mmus ITEEK-----G--RGA-EDGDCEGDSLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQV
MAP3K6_Mmus LVMNPD----S--SAPTEEAEGAREVLEFDYEYSETGERLVLGRGTYGVVYAGRDRHTRV
MAP3K7_Mmus MLNNGV----G--STVELEGEADGDTLEYEYDHDANGERVVLGKGSYGIVYAGRDLSNQV
MAP3K7_Hsap MITNTA----G--STVELEGETDGDTLEYEYDHDANGERVVLGKGTYGIVYAGRDLSNQV
MAP3K5_Hsap ITEEK-----G--RST-EEGDCESDLLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQV
MAP3K6_Hsap WVTNPD----S--TAPAEEAEGAGEMLEFDYEYTETGERLVLGKGTYGVVYAGRDRHTRV
ASK_Spur MLGSSA----V--IGGEVDSDLNDEPIQIEYEFTESKDRVMLGRGTFGVVYAARDCRTQV
AqueK224_Aque LMDSTKLEKSGSSKLTRRMTIDEEDTVEFEYELNDLHEPVVLGKGSFGIVYSAIDLVTKK
:. :*: ::**:*::* **:. * .:
nsy-1_Cele QIVVKEIEVKYDEEVQPLMEEISLHSTLCHANIVQYLGCDLVGKDGSNDHFLIFMEHVPG
Pk92B_Dmel RIAIKEVPEKNSQDVQPLHEEIKLHSQLRHRNIVRYLGSC-----SENGFFKIFMEQVPG
MAP3K5_Mmus RIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSF-----SENGFIKIFMEQVPG
MAP3K6_Mmus RIAIKEIPERDSRFSQPLHEEIALHKRLRHKNIVRYLGSA-----SQGGYLKIFMEEVPG
MAP3K7_Mmus RIAIKEIPERDIRYSQPLHEEIALHKYLKHRNIVQYLGSV-----SENGYIKIFMEQVPG
MAP3K7_Hsap RIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSV-----SENGYIKIFMEQVPG
MAP3K5_Hsap RIAIKEIPERDSRYSQPLHEEIALHKHLKHKNIVQYLGSF-----SENGFIKIFMEQVPG
MAP3K6_Hsap RIAIKEIPERDSRFSQPLHEEIALHRRLRHKNIVRYLGSA-----SQGGYLKIFMEEVPG
ASK_Spur TIAVKEIPITDMREVQPLHEEILLHSRLSHKNIVKYLGSD-----IVGNTFKIYMEQVPG
AqueK224_Aque KMAIKEIPERTEGQFQSLEEEIQLHRHLQHENIVQYFGAY-----SDGGIFRIFMEQVPG
:.:**: *.* *** ** * * ***:*:*. .. : *:**.***
nsy-1_Cele GSLSSLLRSKWGPMN--ENAMNYYGKQILEGLKYLHELKIVHRDIKGDNVLVNTYSGVCK
Pk92B_Dmel GSLSDLLETKWGPLKDNESTMAFYSKQILEGLKYLHEQDIVHRDIKGDNVLVNTYSGVVK
MAP3K5_Mmus GSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLK
MAP3K6_Mmus GSLSSLLRSVWGPLKDNESTISFYTRQILQGLSYLHENRIVHRDIKGDNVLINTFSGLLK
MAP3K7_Mmus GSLSALLRSKWGPMK--EPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVK
MAP3K7_Hsap GSLSALLRSKWGPMK--EPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVLVNTYSGVVK
MAP3K5_Hsap GSLSALLRSKWGPLKDNEQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLK
MAP3K6_Hsap GSLSSLLRSVWGPLKDNESTISFYTRQILQGLGYLHDNHIVHRDIKGDNVLINTFSGLLK
ASK_Spur GSLSALLRSKWGPLKDHEDTIIYYTKQILEGLRYLHDQKIVHRDIKGDNVLVNTYSGVVK
AqueK224_Aque GSLSHLLKFTWGPLINDEGTIRHYTRQILKGLGYLHNQKIVHRDIKGDNVLVNMYSGQIK
**** **. ***: * :: .* :***:** ***: ************:* :** *
nsy-1_Cele ISDFGTCKRLAGLNPVTETFTGTLQYMAPEVIDHGQRGYGAPADIWSFGCTMVEMATGRP
Pk92B_Dmel ISDFGTSKRLARINPMTETFTGTLQYMAPEVIDQGVRGYGPAADIWSFGCTNVEMATGKP
MAP3K5_Mmus ISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKP
MAP3K6_Mmus ISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRP
MAP3K7_Mmus ISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSRP
MAP3K7_Hsap ISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCTIIEMATSKP
MAP3K5_Hsap ISDFGTSKRLAGINPCTETFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKP
MAP3K6_Hsap ISDFGTSKRLAGITPCTETFTGTLQYMAPEIIDQGPRGYGKAADIWSLGCTVIEMATGRP
ASK_Spur ISDFGTSKRLAGLNPAASSFKGTLQYMAPEVIDKGLRGHGAPADIWSLGCTIVEMATGKP
AqueK224_Aque ISDFG-----------------TFQFMAPEVIASGQRGYGPPADVWSLGCTVIEMVTGKP
***** *:*:****:* * **:* .**:**:*** :**.*.:*
nsy-1_Cele PFVEMQNPQAAMFRVGMFKTHPPIPTEITEKCRNFIKSCFLPEACDRPSAKDLLQDPFIY
Pk92B_Dmel PFIELGSAHAAMFKVGFYKKHPNIPEELSANAKNFILRCFAISVMDRPSASQLLEDPFLQ
MAP3K5_Mmus PFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLIDEFLK
MAP3K6_Mmus PFHELGSPQAAMFQVGMYKVHPPVPGSLSAEAQAFLLRTFEPDPRLRASAQELLGDPFLQ
MAP3K7_Mmus PFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPQKRVTAADLLQEGFLR
MAP3K7_Hsap PFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTAELLREGFLR
MAP3K5_Hsap PFYELGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVDEFLK
MAP3K6_Hsap PFHELGSPQAAMFQVGMYKVHPPMPSSLSAEAQAFLLRTFEPDPRLRASAQTLLGDPFLQ
ASK_Spur PFIELGSPQAAMFKVGFYKDHPEIPESLSNAAKEFILRCFEPDPEKRATAHDLLQDPFLI
AqueK224_Aque PFFELGPPEAAVFKVGTFKEHPEIPDVLSKELKSFLLSCFEPEPSKRAIVSELLQNSFIT
** *: ..**:*:** :* ** :* :: : *: * . * . ** : *:
nsy-1_Cele HNHHSISRTRSGSINKKPATKIELNHDKEKKEKSKNQREMLRSTSHIGGMGVVERSPPTP
Pk92B_Dmel DKPRK--VRPAL--P--------------------INTEFGRSISV--------PA-DRF
MAP3K5_Mmus VSSKKKKTQPKL--S----------------ALSTGSNEYLRSIS--------LPV-PVL
MAP3K6_Mmus PGKRSRS---PG-----------------------SPRHTPRPSGAP------SGP-SSP
MAP3K7_Mmus QVNKGKKNRIAF-----------------------KPSEGVRSGTGT------LAL-PSS
MAP3K7_Hsap QVNKGKKNRIAF-----------------------KPSEGPRGVV--------LAL-PTQ
MAP3K5_Hsap VSSKKKKTQPKL--S----------------ALSAGSNEYLRSIS--------LPV-PVL
MAP3K6_Hsap PGKRSRS---PS-----------------------SPRHAPRPSDAP------SAS-PTP
ASK_Spur KGRKMSKK-TSA-----------------------ADYRTDRSISM--------PM-VNP
AqueK224_Aque RKKKK--VNVSD-----------------------APPEFMRSKSMF-------PG-A--
: . *
nsy-1_Cele EPMSATLTAGFSHVHSQTVSNALSTAREEKKLHLKIDHARNRTFSSSSPV-PDGQSSA--
Pk92B_Dmel VHK-TTPPLS----YNTTCN--T----------------------PTTPEL-DITHSSSV
MAP3K5_Mmus VED-TSSSSE----YG-----------------------------SVSPD-TELKADP--
MAP3K6_Mmus SADSATQSQT-----------------------------------FPRPQ-APSQH-P--
MAP3K7_Mmus GELVGSSSSE----HG-----------------------------SISPD-SDAQPDA--
MAP3K7_Hsap GEPMATSSSE----HG-----------------------------SVSPD-SDAQPDA--
MAP3K5_Hsap VED-TSSSSE----YG-----------------------------SVSPD-TELKVDP--
MAP3K6_Hsap SANSTTQSQT-----------------------------------FPCPQ-APSQH-P--
ASK_Spur GSRP-ESPLT----LASTLS--------------------------NFSEA-DAA---S-
AqueK224_Aque ----------------------L----------------------PSAEHDKELTMSS--
nsy-1_Cele --GTNMSHPGFQLSQPSSPIVDDTNHPHLIVSPISLNTMGSPLSSAALLNRTISDES-SN
Pk92B_Dmel DID---ELPSNQ-F-----------MLER--RNSHGFLLS-PEIEPSTPSLRTSISE-TS
MAP3K5_Mmus --F---SFKARAKS-----------CGEKDGKGIRTLFLGIPDEN--FEDHSAPPSP-EE
MAP3K6_Mmus --P---SPPKRCLS-----------YG-------DTSQLRVPEEPAA----EEPASP-EE
MAP3K7_Mmus --F---FEKVQVPK-----------H-------QLSHLLSVPDESPALDDRSTALPP-EE
MAP3K7_Hsap --L---FERTRAPR-----------H-------HLGHLLSVPDESSALEDRGLASSP-ED
MAP3K5_Hsap --F---SFKTRAKS-----------CGERDVKGIRTLFLGIPDEN--FEDHSAPPSP-EE
MAP3K6_Hsap --P---SPPKRCLS-----------YG-------GTSQLRVPEEPAA----EEPASP-EE
ASK_Spur -S-------------------------------------------SSEDGLETPVTP-DN
AqueK224_Aque --N---STPGASKS-----------ILERSKSASTQRKFSNSNEM--AEGSSEGETPTSS
.
nsy-1_Cele S-SS------RFFMLQKDSERRRSLGQFMQDYKDLIIDSWSTLLIKQSD-TELVVTVYML
Pk92B_Dmel E-TD------GFYRLKKDSQRRTTLSKVLALDESKICDIWLKKVDADQ------------
MAP3K5_Mmus K-DS------GFFMLRKDSERRATLHRILTEDQDKVVRNLMESLAQGAEE--PKLKWEHI
MAP3K6_Mmus --SS------GLSLLHQESKRRAMLAAVLEQEVPTLAENLLE---Q-EQD--SRLSKIHV
MAP3K7_Mmus R-DP------GLFLLRKDSERRAILYRILWEEQNQVASNLQECVVQSSEE--LLLSVSHI
MAP3K7_Hsap R-DQ------GLFLLRKDSERRAILYKILWEEQNQVASNLQECVAQSSEE--LHLSVGHI
MAP3K5_Hsap K-DS------GFFMLRKDSERRATLHRILTEDQDKIVRNLMESLAQGAEE--PKLKWEHI
MAP3K6_Hsap --SS------GLSLLHQESKRRAMLAAVLEQELPALAENLHQEQKQ-EQG--ARLGRNHV
ASK_Spur REQG------GFYMLRKDSERRQTLLTIIEGDGDKIVNEWMKKLQLSGDRPPTKITTDHL
AqueK224_Aque T-NDGVFSRSDFSRVLWDSE----------------------------------------
: : :*:
nsy-1_Cele EMLLDGMRDFLLKKDNTKMQKMIDDIRGLLDYDTAKIGQINLALYHFSDSIQPVLRRL--
Pk92B_Dmel --------------------------------NSIAI-----RKSDLEDAVVCVLRYH--
MAP3K5_Mmus TTLISSLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNH--
MAP3K6_Mmus ELLLRCLGAQIHTPNRRQLAQELRTLQAQLRAQSLGPALLKGPLFAFPDAVKQILRRR--
MAP3K7_Mmus KQIIGILRDFIRSPEHRVMAATISKLKVDLDFDSSSINQIHLILFGFQDAVNRILRNH--
MAP3K7_Hsap KQIIGILRDFIRSPEHRVMATTISKLKVDLDFDSSSISQIHLVLFGFQDAVNKILRNH--
MAP3K5_Hsap TTLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNH--
MAP3K6_Hsap EELLRCLGAHIHTPNRRQLAQELRALQGRLRAQGLGPALLHRPLFAFPDAVKQILRKR--
ASK_Spur MTLNHGIALFIKQRERRMLVGTLDKLRDDLDYDPTALSEIHTALYVFQDSVNQVLRQHMH
AqueK224_Aque ------------------------------------------------------------
nsy-1_Cele DIKPHWMFALSNLITSAVQCAISILSPDLSLLL-HAQD-NLPSTSSIVAIR------N--
Pk92B_Dmel CIKPHWMFALDNLVKRAVQAAVTIFSPELGANL-ADKD-LSGNDDESLRTSLMQKGSTES
MAP3K5_Mmus NIKPHWMFALDSIIRKAVQTAITILVPELRPHF-SLASESDTADPEDLDVE------DEH
MAP3K6_Mmus QIRPHWMFVLDSLLSRAVRAAMAVLDAESEKKAVLPRSEE-SSKEE-SQ-----------
MAP3K7_Mmus LIRPHWMFAMDNIIRRAVQAAVTILIPELQAHF-EPASETEGVDK-DTEVE------GDY
MAP3K7_Hsap LIRPHWMFAMDNIIRRAVQAAVTILIPELRAHF-EPTCETEGVDK-DMDEA------EE-
MAP3K5_Hsap NIKPHWMFALDSIIRKAVQTAITILVPELRPHF-SLASESDTADQEDLDVE------DDH
MAP3K6_Hsap QIRPHWMFVLDSLLSRAVRAALGVLGPEVEKEAVSPRSEE-LSNEGDSQ-----------
ASK_Spur NIKPHWMFALDSLIRDAVQVTITILSPDLGENI-APSKEDDVTPA-NSHGM-----DTRN
AqueK224_Aque ------------------------------------------------------------
nsy-1_Cele SSL--SEG--------EAL-------------------------IESRPPSREERVREDR
Pk92B_Dmel QEK--QSL--------EKV-LPTSNTREGV-----GLT-PAESGGDALSSSMECAR----
MAP3K5_Mmus EEL--SSN--------QTVRRPQAITEDAVATSGVSTL-SSTVSHDSQNAHRSLNV----
MAP3K6_Mmus -QK--PQE--------SQA------------------L-QSQL--PPEQGPPSLMV----
MAP3K7_Mmus PLVDLLSQ--------EVHVTPRGT----------R-P-GSVAIQEGQPHQQDPSL----
MAP3K7_Hsap -----------------------GY----------P-P-ATGPGQEAQPHQQHLSL----
MAP3K5_Hsap EEQ--PSN--------QTVRRPQAVIEDAVATSGVSTL-SSTVSHDSQSAHRSLNV----
MAP3K6_Hsap -QS--PGQ--------QSP------------------L--PV---EPEQGPAPLMV----
ASK_Spur PGTSSGGGGGIYGTAPHFLPLPKGVDEEAGNTSGVSTFDSSTRSNECFIPNRNLMA-NLQ
AqueK224_Aque ------------------------------------------------------------
nsy-1_Cele KELRTLQEENEILIERL--------------L----------------------------
Pk92B_Dmel -ILRDIRDNQQKLQRQLLEQQRQSM----RALHNISQELAHIYMGGRKRLRRTINGFNKK
MAP3K5_Mmus -QLGRMKIETNRLLEELVRKERELQALLHQAIEEKDQEIRHLKLKSQPI-----------
MAP3K6_Mmus -ELGLLRAETDRLRDLLAEKERECQALVQQALHRVHAETRKYAPASE-------------
MAP3K7_Mmus -QLSKLRQETNRLWEHLVQKEREYQNLLRLILDQKTQELYHLQLQYKSN-----------
MAP3K7_Hsap -QLGELRQETNRLLEHLVEKEREYQNLLRQTLEQKTQELYHLQLKLKSN-----------
MAP3K5_Hsap -QLGRMKIETNRLLEELVRKEKELQALLHRAIEEKDQEIKHLKLKSQPI-----------
MAP3K6_Hsap -QLSLLRAETDRLREILAGKEREYQALVQRALQRLNEEARTYVLAPE-------------
ASK_Spur GDHQRLVQEQGRLLQELVDVQKSLNDVLQTQLCVSRSVMERIG--FQPL-----------
AqueK224_Aque ---------TKELLNIVLSKDREMV----KS-----------------------------
* :
nsy-1_Cele ------------------------------------QEELVSWLRGLEIDERSIALIASE
Pk92B_Dmel CHRMSTSVGGTSGVRPNIAGNPRRQLNKHHFGLHEVDEQLEQWLTQQEIDEFSKTLILNE
MAP3K5_Mmus ----------------DIPGFPVCHLN--SPGTTTEDSELPGWLRENGADEDTISRFLAE
MAP3K6_Mmus -----------------------------TPATLPKDQNLVRWLQELSVDPATIQTLLSH
MAP3K7_Mmus ----------------GGTENPP------PPDGLGTDRELIDWLQLQGVDANTIEKIVEE
MAP3K7_Hsap ----------------CITENPA------GPYGQRTDKELIDWLRLQGADAKTIEKIVEE
MAP3K5_Hsap ----------------EIPELPVFHLN--SSGTNTEDSELTDWLRVNGADEDTISRFLAE
MAP3K6_Hsap -----------------------------PPTALSTDQGLVQWLQELNVDSGTIQMLLNH
ASK_Spur ----------------GATDSVNSNLQDGRAGVEAKQEELSSWLQAVGLDEDSIRRFIEE
AqueK224_Aque -------------------------------------------FFIARICKNVQKTLQEK
: : .
nsy-1_Cele AYTKSDMMDFVTRDELLSIGVGGGSSCRIMRAIGEVRERQRLF-----------------
Pk92B_Dmel GFTFDDFIYNMEKLDLMRLGLRVGIEVRLWKLIIQERVCTSSDCVDSPPSTYHKPIGGNS
MAP3K5_Mmus DYTLVDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRN----------------------
MAP3K6_Mmus SFTLQTLLTCATQDDLVYTRIRGGMVCRIWRAILAQRAGATSV-----------------
MAP3K7_Mmus DYTLSDILNDITKEDLRCLRLRGGVLCRLWHAVSQHRRQMQ-------------------
MAP3K7_Hsap GYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEAS-----------------
MAP3K5_Hsap DYTLLDVLYYVTRDDLKCLRLRGGMLCTLWKAIIDFRNK---------------------
MAP3K6_Hsap SFTLHTLLTYATRDDLIYTRIRGGMVCRIWRAILAQRAGSTPV-----------------
ASK_Spur DLTLPLVLNSMTRDDLRSLKIRVGAQVRIWDAVQQHRMNE--------------------
AqueK224_Aque IPSLHLTMVHNTHDK----EGGGGLFL---------------------------------
: : : . *
nsy-1_Cele --------------------------------LSLSLILL
Pk92B_Dmel SFALIDNNNTLPSPTTTTPGTPGIKTKIKKSESEYDSCSE
MAP3K5_Mmus --------------------------------------KC
MAP3K6_Mmus --------------------------------TPVPRDAE
MAP3K7_Mmus ------------------------------------ESSQ
MAP3K7_Hsap ----------------------------------ETKDKA
MAP3K5_Hsap --------------------------------------QT
MAP3K6_Hsap ------------------------------------TSGP
ASK_Spur -------------------------------------QKR
AqueK224_Aque -----------------------------------FLGTP