cdc2_Dmel FEKIEKIGEGTYGVVYKGRN-RLTGQIVAMKKIRLE-SD---DEGVPSTAIREISLLKEL
CDC2_Mmus YIKIEKIGEGTYGVVYKGRH-RVTGQIVAMKKIRLE-SE---EEGVPSTAIREISLLKEL
K03E5.3_Cele FCSLRRIGEGTYGVVFKAIH-VRDNVKCALKMIRTD-RD---EEGIPSTCLREISCIKDL
cdk-1_Cele FTKLEKIGEGTYGVVYKGKN-RRTNAMVAMKKIRLE-SE---DEGVPSTAVREISLLKEL
CDC2_Hsap YTKIEKIGEGTYGVVYKGRH-KTTGQVVAMKKIRLE-SE---EEGVPSTAIREISLLKEL
21071_Tthe YEVLNVIGKGTYGEVFRARD-QETHEIVALKKTITK-LE---NDGIPSSALREISLLKEI
21599_Tthe YEKLLKVGEGTYGEVYKAKD-IQSSEIVALKKIKLE-NE---DEGVPSTALREISILKEL
23583_Tthe YLRIKKINEGSFGKIILCELVDQKGQYCVLKKFKVT-Q-Q---SAIDELSIKEIYYMKKL
25533_Tthe FKCLQKIGEGTYGIVYKGFD-TQTNTQVAIKKVKLD-QE---QEGIPQSALREICILKDL
25907_Tthe YVQLEKLGEGTYGVVFKAQD-MQTQQLVAIKQIRIDPNE---DEGVPSTTLREISILKKL
26482_Tthe ----------------------------------------------PTSILRELSYLQAL
6129_Tthe FQKIKMLGEGTYGHVTKCQD-KQTKEVVAVKKIKLEIFQ---GDGFPSSSMREISTLKKM
6298_Tthe YQKIKKIGEGTYGKVFQAKD-LKTDQIVALKKVKND-YEEIGDEGIPSTALREISCLKAL
9560_Tthe YQRTEKIGEGTYGIVYKAID-MQTNDIIALKKIRLE-HE---DEGVPSTAIREISLLKEI
CDC2_Spur FMKIEKLGEGTYGVVYKGKH-KRTGKIVALKKIRLE-SE---EEGVPSTAIREISLLKEL
n1179_Tthe FTQIHQLGEGTFGKVYKAQD-KKNNEIVAVKQVKIH-DE---REGFPVTSVREIKLLSEL
CC1G_02703_Ccin ---------GTYGVVYKARD-TSTNTIVALKKIRLE-AE---DEGVPSTAIREISLLKEL
AqueK094_Aque YTKLEKIGEGTYGVVYKARH-KVTGKTVALKKIRLE-NE---EEGVPSTAIREISILKEV
CDC2-2_Smoe YEKVEKIGEGTYGVVYKARD-RITNETIALKKIRLD-QE---DEGVPSTAIREISLLKEM
CDC2-1_Smoe YEKVEKIGEGTYGVVYKARD-RITNETIALKKIRLD-QE---DEGVPSTAIREISLLKEM
GK021_Glam TDLVTLIGSGTYGDVYRCQH-KQTKTWYAIKRIKEG-KES--KMGLTGDKFMEILAFREL
GK020_Glam YRRITKLGEGTYGEVYKAID-TVTNETVAIKRIRLE-HE---EEGVPGTAIREVSLLKEL
GK022_Glam YEFISQIGEGTYGTVSKCS---LHGQLLAVKRIKMD-SS---SKGVPATTLREVAILKAL
. *: : :
cdc2_Dmel K----------------HENIVCLEDVLME----------------ENRIYLIFEFLSMD
CDC2_Mmus R----------------HPNIVSLQDVLMQ----------------DSRLYLIFEFLSMD
K03E5.3_Cele Q----------------HDNIVTLFDIIYASHFLNYNNIFFEKFSSNSKLYMVFEFIDRD
cdk-1_Cele Q----------------HPNVVGLEAVIMQ----------------ENRLFLIFEFLSFD
CDC2_Hsap R----------------HPNIVSLQDVLMQ----------------DSRLYLIFEFLSMD
21071_Tthe N----------------HENVVVLKDIIIQ----------------NNLLYLVFEFCESD
21599_Tthe Q---------------PHPNIVCMHEVIYQP--------------QEKKLYLVFEFVDQD
23583_Tthe D----------------HPNLVKSDDIFKIK--------------KSYNGQDFFEQLYMH
25533_Tthe S---------------DHQNIVKLRDVIYQI--------------EESKLFLVFEYVDYD
25907_Tthe K----------------HKNIVKLLDVYVFP--------------EAQKVSLVFEYYPQD
26482_Tthe D----------------HPNITKIHEVDIK----------------NVIVQIVTKRQEYN
6129_Tthe K----------------HENIVILKDVQFQF--------------DENSLLMVFECLECD
6298_Tthe D----------------HPNVVKLVDVVYIM--------------KKNKLYLVFEYIDYD
9560_Tthe D----------------HPNVIKLRDLVYG----------------ENKLYLIFDYLDHD
CDC2_Spur Y----------------HPNIVMLEDVLME----------------PNRLYLVFEYLTMD
n1179_Tthe Q---------------NHPNIVQFKEVVVGQ--------------NQNSIFLIFEYCQMD
CC1G_02703_Ccin K----------------DDNIVKLLDIVHA----------------DQKLYLVFEFLDVD
AqueK094_Aque Q----------------HTNVVKLEDIIHQ----------------DLKLYLVFEFMCMD
CDC2-2_Smoe Q----------------HGNIVRLQDVVHC----------------EKKLYLVFEYLDLD
CDC2-1_Smoe Q----------------HGNIVRLQDVVHC----------------EKKLYLVFEYLDLD
GK021_Glam S----------------HPNILSCKSIFFH----------------GARLCFALELCNTS
GK020_Glam Q----------------HRNIIELKSVIHH----------------NHRLHLIFEYAEND
GK022_Glam NAKQRELVEQGKLESLSQANVVNLLDVVYD----------------LSNIFLVFEYCHVD
. *: : .
cdc2_Dmel LKKYMDSLPV----------D--KHMESELVRSYLYQITSAILFCHRRRVLHRDLKPQNL
CDC2_Mmus LKKYLDSIPP----------G--QFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNL
K03E5.3_Cele LKNLLEMLEP----------T-NSVLPPNYVKSFMWQLLSALSYCHLRRIVHRDLKPQNI
cdk-1_Cele LKRYMDQLGK----------D--EYLPLETLKSYTFQILQAMCFCHQRRVIHRDLKPQNL
CDC2_Hsap LKKYLDSIPP----------G--QYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNL
21071_Tthe LKKFLDSK---------------TKVAGQFLDALTIKIIRGVAACHTRRIMHRDLKPQNI
21599_Tthe LKKFLDQYRK----------DKKLQLRPYQIKLMMYQILNGLNFCHSRRIIHRDLKPQNI
23583_Tthe LPYYLEMSEV-----------PRENLSVEAIKILIKQLIEAVHFLHQKKIIHRDIKPSNI
25533_Tthe LKKYLETMK---------------HLTQHDIKLIMYQLLNGLDFCHQRRIIHRDIKPQNI
25907_Tthe LRGYLKQLQQ----------KNQKEIPLSFYQNQFRQIIEGVDYCHSQGILHRDLKPQNI
26482_Tthe LKEYTRRYISQVQDDSKGLTRPQYKIPLIKVKEIAYQILEGLNYLHHQGIMHRNLKIDNI
6129_Tthe LKQYLENEF---------------PIQPIKIKQIMKQILQGVDYCHQMQIMHRDLKPQNI
6298_Tthe LKAYQKKIG---------------KIPEQTVKSYMHQILKGIEHCHSRRIFHRDLKPQNI
9560_Tthe LKKYLELN--------------GGPLPPAVVKDYLFQLILGIAVCHANRIVHRDLKPQNI
CDC2_Spur LKKYMESLK-----------G--KQMDPALVKSYLHQMVDGILFCHSRRILHRDLKPQNL
n1179_Tthe IANLIFRMDQ----------E-REYFSESEIKCIILQLLNGVQHMHKQYQMHRDIKLSNV
CC1G_02703_Ccin LKRFIETGNQ----------N-RSPITPALVKKFTHQLNSGLLYCHSHRILHRDLKPQNL
AqueK094_Aque LKKYLDSLPA----------G--KFMEPDLVKSYTYQILKGIVFCHGRRIIHRDLKPQNL
CDC2-2_Smoe LKKHMDNSPD-------------FAKSPRMIKTFLYQMIRGLAYCHSHRVLHRDLKPQNL
CDC2-1_Smoe LKKHMDNSPD-------------FAKSPRMIKTFLYQMIRGLAYCHSHRVLHRDLKPQNL
GK021_Glam LKSILNSG---------------HSLTAEDRRTAYYQILLGLEYLHRNHISHFDLKPDNI
GK020_Glam LKKYMDKNP---------------DVSMRVIKSFLYQLINGVNFCHSRRCLHRDLKPQNL
GK022_Glam LDQYLKH----------------NVLSPYQIKKFMYQLLQGLSLVHKNEILHRDIKPNNI
: :: .: * * ::* .*:
cdc2_Dmel LIDKS----------------------GLIKVADFGLGRS---FGIP-VRIYTH------
CDC2_Mmus LIDDK----------------------GTIKLADFGLARA---FGIP-IRVYTH------
K03E5.3_Cele LVSDS----------------------GVIKIADFGLARN---FSFP-SRNYTH------
cdk-1_Cele LVDNN----------------------GAIKLADFGLARA---IGIP-IRVYTH------
CDC2_Hsap LIDDK----------------------GTIKLADFGLARA---FGIP-IRVYTH------
21071_Tthe LIDKN----------------------------DFGLSRT---FCMP-IRPYTK------
21599_Tthe LIDAK----------------------GNIKIADFGLARA---FGVP-IKTLTH------
23583_Tthe FLDKT----------------------GKLLLGDMGISRD---FPENKDQELTG------
25533_Tthe LIDKA----------------------GNVKIADFGLAKT---FQVP-SKTLTH------
25907_Tthe LVSST----------------------GEIKIADFGLARA---FNYP-LKELTK------
26482_Tthe LLDK-----------------------DVVKISDFGLSRL---VSIP-HIPYTPEDPKER
6129_Tthe LVSTKA------------------NNTMSVKISDFGLAKT---FTTP-LDKYTK------
6298_Tthe LVNNK----------------------GDIKIADFGLGKI---FGIP-LNTITH------
9560_Tthe LINKK----------------------GSVQLADFGLARA---FGLP-LKTYTH------
CDC2_Spur LIDNN----------------------GTIKLADFGLARA---FGIP-VRVYTH------
n1179_Tthe LINDK----------------------GVVKIADFGLARE---YNKP-NKPYTP------
CC1G_02703_Ccin LIDKH----------------------NNLKLADFGLARA---FGIP-MRTYTH------
AqueK094_Aque LIDNN----------------------GGIKIADFGLGRA---FGIP-VRAYTH------
CDC2-2_Smoe LIDRR---------------------TNALKLADFGLARA---FGIP-VRTFTH------
CDC2-1_Smoe LIDRR---------------------TNALKLADFGLARA---FGIP-VRTFTH------
GK021_Glam LIKDNN-------------------GSSVFKITDFGLSLITGRFRGP-SIVYTG------
GK020_Glam LLSVSDA-----------------SETPVLKIGDFGLARA---FGIP-IRQFTH------
GK022_Glam LLAFRGDAGEQLAANASVTTPNPDADNCVLKITDFGLARS---YGIN-VTSISA------
:: *:*:. :
cdc2_Dmel -----EI--VTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAEMA--TR-KPLFQGDSEIDQ
CDC2_Mmus -----EV--VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELA--TK-KPLFHGDSEIDQ
K03E5.3_Cele -----EV--VTLWYRPPEILLGSQRYSTSLDMWSLGCIFSEIA--SN-KPLFPGECEISQ
cdk-1_Cele -----EV--VTLWYRAPEILMGAQRYSMGVDMWSIGCIFAEMA--TK-KPLFQGDSEIDE
CDC2_Hsap -----EV--VTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELA--TK-KPLFHGDSEIDQ
21071_Tthe -----EV--VTLWYRPPEILLGALDYCTPIDMWSVGCIM---------------------
21599_Tthe -----EV--ETLWYRAPEILLGQKAYSLGVDIWSLGCIFHEMV--EK-RALFMGDSEIDQ
23583_Tthe -----NT--ITRLYRPPEILFGCKKYNETVDLWSLGCTIAEFFMDHK-KYFFQGKSEIDQ
25533_Tthe -----EV--ETLWYRPPEILLGVKTYSLAIDMWSIGCVFYELM--EK-KPLFISDSEIEA
25907_Tthe -----DI--VTLWYRSTELLLGESQYDIAIDMWSVGCILAEFV--TF-KPLFMGDSQIDQ
26482_Tthe ERSGREA--RRLWYRAPELLLRKSIYTFEIDMWSFGCLLAEIV--LN-EPLFAGDSEIEQ
6129_Tthe -----EI--ATLWYRAPEVMLGDEHYSITIDIWAVGCIFIELI--TK-RPPFHAQSQIDQ
6298_Tthe -----EV--ETLWYRAPEILLGDKLYSLPVDVWSIGCIFAELI--IG-HPLFHGDSEIDQ
9560_Tthe -----EV--VTLWYRPPEILLGQKQYSTPVDIWSIGCIFSEMA--QK-IPLFIGDSEIDQ
CDC2_Spur -----EV--VTLWYRAPEVLLGSTRYACPIDMWSLGCIFAEMV--TK-RPLFHGDSEIDQ
n1179_Tthe -----KV--VTLWYRSPELLLEMEQYTTSIDIW---------------------------
CC1G_02703_Ccin -----EV--VTLWYRAPEVLLGSRHYSTAIDMWSVGCIFAEMA--MQGAPLFPGDSEIDQ
AqueK094_Aque -----EV--VTLWYRAPEVLLGCPRYSCPLDIWSIGCIFAEMS--NK-KPFFQGDSEIDQ
CDC2-2_Smoe -----EV--VTLWYRAPEILLGSRHYSTPVDMWSVGCIFAEMI--NQ-RPLFPGDSEIDE
CDC2-1_Smoe -----EV--VTLWYRAPEILLGSRHYSTPVDMWSVGCIFAEMI--NQ-RPLFPGDSEIDE
GK021_Glam -----PGFRWTPIYRPPEVFGSTLEVGQSSDMWSIGLTFFEMI--IQ-TAVIQAE-ESRI
GK020_Glam -----EI--ITLWYRPPEILLGSRHYSTSVDIWSIACIWAEML--MK-TPLFPGDSEIDQ
GK022_Glam -----NV--VSLWYRAPELVLASKTYSTAVDMWSMGCIMYFLA--NK-RALFQVRKDADL
**..*:. *:*
cdc2_Dmel LFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQ--------------------
CDC2_Mmus LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASH--------------------
K03E5.3_Cele LFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQWPV-NLKKLE-ET----------------
cdk-1_Cele LFRIFRVLGTPTELEWNGVESLPDYKATFPKWRENFLRDKF-YD----------------
CDC2_Hsap LFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASH--------------------
21071_Tthe ------ILGTPTENDWPGIKDLTDYKPTFPRFRPQKLSEMI-ENIY--------------
21599_Tthe IFKIFQYHGTPTEQTWPALKECPYFKPIYPRFKTADPKTYF-K-----------------
23583_Tthe LCKVFEIRGSANEQNWPGCTELPYYM-DFGELNQKDLSSL--------------------
25533_Tthe IFKIFQFHGTPNSETFQGLEDYPYFKSTFPRFHAQDPFIVF-K-----------------
25907_Tthe LFKIFQFSGTPNGVIWPNVKKYIDFKQTFPKFLPSNTLRID-PRF---------------
26482_Tthe LFKVFKFIGSPDSETLMSMCDNPDYQQTFPKWKMINLSHIC-EQNQSEEFKQLKTTMIPN
6129_Tthe LFQIFQIFGTPNEQTYPGISKLPDYNEKFPKFQAQGIQKLL-PS----------------
6298_Tthe IFKIFQFFGTPKSSKLEGTYNLKYWSNLFPRFKSQKDEILK-PI----------------
9560_Tthe IFKIFRIMGTPSESTWPGVTQLPDFKNTFPRWNPIPLQKQ--------------------
CDC2_Spur LFRIFRTLGTPTDDIWPGVTQLQDYKSTFPMWTKPNIKGA--------------------
n1179_Tthe ------------------------------------------------------------
CC1G_02703_Ccin IFKIFRLLGTPNEDIWPGVSTLPDYKPTFPNWSRQDLAKA--------------------
AqueK094_Aque LFRIFRILGTPSDAIWPSVTTMPNFKSTFPKWTGKSLSQL--------------------
CDC2-2_Smoe LFKIFRILGTPNEETWPGVTSLPDFKSAFPKWLPKDLATL--------------------
CDC2-1_Smoe LFKIFRILGTPNEETWPGVTSLPDFKSAFPKWLPKDLATL--------------------
GK021_Glam PAKIADLLGRLPNDTDPGVTD---WHGSFINLCGKDYSPPT-QPYM--------------
GK020_Glam LFKIFEVLGLPDDTTWPGVTALPDWKQSFPKFRGKTLKRV--------------------
GK022_Glam LQLAFSYFYVDS-SSISDLISLPNWNMYVGENQVIDLAALNAPG-R--------------
cdc2_Dmel -----------LK-NLDANGIDLIQKMLIYDPVHRISAKDILEHPYF
CDC2_Mmus -----------VK-NLDENGLDLLSKMLVYDPAKRISGKMALKHPYF
K03E5.3_Cele -------------SCLTGNGLDVLREILRYPPERRLTAKGALSHRYF
cdk-1_Cele -------KKTGKH-LLDDTAFSLLEGLLIYDPSLRLNAKKALVHPYF
CDC2_Hsap -----------VK-NLDENGLDLLSKMLIYDPAKRISGKMALNHPYF
21071_Tthe ------KKYNQN-SEVDIAAVDLLQRLLCYDPIKRITAKSALNHIKI
21599_Tthe --------------NFCDKGFDLIQQMIALDPAKRISVKDALRHPYF
23583_Tthe -----------LP-KAPKECIEIIDSLLQLCPQKRAKIEDIIQNKWL
25533_Tthe --------------NLENDARDLLMQMIALNPLDRISVKQALLHPYF
25907_Tthe -----------KE-QIRNEGIELIESLLQIVPEKRLNSDEALKAPFF
26482_Tthe RQNGFQKLKNLGT-ILGMQGMQLLNSLLQLNPYKRISSQEALNHPFF
6129_Tthe -------------NFNDPEALDLLSNLLVLDPSRRIFSKEALKHPYF
6298_Tthe -------------IETDPQAADLLVKLIDIEPAKRISVSQALKHPYF
9560_Tthe -----------CP-NICPKGIDLLTKMLQLDPTKRITAEEALDHPYF
CDC2_Spur -----------VK-GMDEGGLDLLEQMLIYDPAKRITAKASMRHPYF
n1179_Tthe -----------------------------------------------
CC1G_02703_Ccin -----------VP-TLDEAGIDMLKRTLTYDSAKRLSAKRALVHPYF
AqueK094_Aque -----------CP-HLDSIGCDLLMQMVIYNPGKRISAKRAMEHPYF
CDC2-2_Smoe -----------VP-GLEHAGVDLLSKMLCLDPSSRITARAALEHDYF
CDC2-1_Smoe -----------VP-GLEHAGVDLLSKMLCLDPSSRITARAALEHDYF
GK021_Glam ------HTLFER-HGVRPEEKQFIAKFLQYSPEARITAADALQDPFL
GK020_Glam -----------LGALLDDEGLDLLTAMLEMDPVKRISAKNALEHPYF
GK022_Glam ------KPREVDI-NIDDVGKDLFYKLLMLNPSKRISCDEALQHPWF