mnb_Dmel        YEIDSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENK
DYRK1B_Mmus     YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK
DYRK1A_Mmus     YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK
mbk-1_Cele      ILSDTPVGKGSFGQVTKAYDTLNKEEVAIKIIKNKKTFFDQAQIEIHLLELTNAHDKDNK
DYRK1B_Hsap     YEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMK
DYRK1A_Hsap     YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK
Dyrk1_Ddis      FEIISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALIEIRLLELMNNKDPEDQ
DYRK1_Spur      YEIDSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQIEVRLLELMNKHDADSK
AqueK110_Aque   ------------------------------------------------------------
AqueK111_Aque   YEIDSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQALIEKRLLELLNSRDPEGK
GK031_Glam      YCAERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGREEAEIMSLLSDEDPPIS


mnb_Dmel        YYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLST
DYRK1B_Mmus     YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT
DYRK1A_Mmus     YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT
mbk-1_Cele      YNIVTLKGHFVHRAHLCLVFELLSYNLYDLLKNTSFRGVSLNLARKFAQQLGKTLLFLSS
DYRK1B_Hsap     YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLAT
DYRK1A_Hsap     YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT
Dyrk1_Ddis      YKIIKLKHHFKFRNHLCIVTELLSYNLYDLLRNTHFHGVSLNLIKKFAHQILTALFFMST
DYRK1_Spur      YYIVKLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLAT
AqueK110_Aque   ------------------------------------------------------------
AqueK111_Aque   YYIVSLKRSFTFRGHLCFVFELLSYNLYELLRNTNFRGVSLNLTRKFAQQLCTALLFLST
GK031_Glam      CKF---IESFMQGNHYCIVMEALGSNLYHLLKSTKMQGFPLQTIRVWARKYLTSFKKLQH


mnb_Dmel        PELNIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIYHYIQSRFYRSPEVLLG
DYRK1B_Mmus     PELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLG
DYRK1A_Mmus     PELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLG
mbk-1_Cele      PELSIIHCDLKPENVLL--VNAKRSQIRVIDFGSSCQTGH-RIYQYIQSRFYRSPEVLLG
DYRK1B_Hsap     PELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLG
DYRK1A_Hsap     PELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLG
Dyrk1_Ddis      PEVDVIHCDLKPENILL--RNPKRSAIKIIDFGSSCHSNE-RMYKYIQSRFYRSPEILLE
DYRK1_Spur      PELNIIHCDLKPENILL--CNPKRSAIKIIDFGSSCQLGQ-RIYQYIQSRFYRSPEVLLG
AqueK110_Aque   ------------------------------------------------------------
AqueK111_Aque   HDINVIHCDLKPENILL--CNPKRSAIRIVDFGSSCQVGS-RMFQYIQSRFYRSPEVLLG
GK031_Glam      ESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEGQMFLYIQSRYYRAPEVLLL


mnb_Dmel        IQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYL-----------
DYRK1B_Mmus     TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGIPPAPMLEQ-APKARKY
DYRK1A_Mmus     MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQ-APKARKF
mbk-1_Cele      IAYDTKIDMWSLGCILVEMHTGEPLFAGSSEVDQMMKIVEVLGMPPKEMLDI-GPKTHKY
DYRK1B_Hsap     TPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQ-APKARKY
DYRK1A_Hsap     MPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQ-APKARKF
Dyrk1_Ddis      LEYSFSIDMWSLGCILVEMHVGEPLFSGQNEQDQLTKIIEVLDLPPSHMIDS-SPKAKKF
DYRK1_Spur      ISYDMAIDMWSLGCILVEMHTGEPLFSGSNELDQMNKIIEVLGMPPNHIIEQ-APKAHKY
AqueK110_Aque   -------------------------------------------------------RRDRF
AqueK111_Aque   IPYDLAIDMWSLGCILVEMHTGEPLFSGKDEIDQMSKIVEVLGIPPPHVLER-SARRDRF
GK031_Glam      QPYDYQIDIWSIAAILFEMHTGKVLFPAKSSEILCYMMVDILGYPPKEMIMDEEQKQ---


mnb_Dmel        ------------------------------------------------------------
DYRK1B_Mmus     FERLP-GGGWTLRRTKELRK--------D-YQGPGTRRLQEVLGVQTGGPGG--------
DYRK1A_Mmus     FEKLP-DGTWSLKKTKDGKR--------E-YKPPGTRKLHNILGVETGGPGG--------
mbk-1_Cele      FDKTE-DGIYYCKKTRDGYR--------HTYKAPGARKLHEILGVTSGGPGG--------
DYRK1B_Hsap     FERLP-GGGWTLRRTKELRK--------D-YQGPGTRRLQEVLGVQTGGPGG--------
DYRK1A_Hsap     FEKLP-DGTWNLKKTKDGKR--------E-YKPPGTRKLHNILGVETGGPGG--------
Dyrk1_Ddis      FTKDPINSTYQLKKNEKLKT--------N-V-EFCKKKLSEIIGVETGGPQS--------
DYRK1_Spur      FIKT--EKTWVLKRSRDGKK----------YKSPRTRKLQDILGVELGGPGG--------
AqueK110_Aque   FERES-GGTWVLKRQRDGRK--------DHHRRPGSRSLYEVLGGDKGGPGG--------
AqueK111_Aque   FERES-GGTWVLKRQRDGRK--------DHHRRPGSRSLYEILGGDKGGPGG--------
GK031_Glam      ISNSLK-RYFKMRKQEDAELFHLNENAFPHQVVPDSYLLNKSVIEMAEAQKERIFGRPLR


mnb_Dmel        ------------------YLKFKDLILRMLDFDPKTRVTPYYALQHNFF
DYRK1B_Mmus     ------RRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF
DYRK1A_Mmus     ------RRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF
mbk-1_Cele      ------RRLGEPGHSVEDYSKFKDLIKRMLQFDPKQRISPYYVVRHPFL
DYRK1B_Hsap     ------RRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFF
DYRK1A_Hsap     ------RRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFF
Dyrk1_Ddis      ------RRKNEPGHALVDYLKFLDLIEKMLIYDPQKRITPLEALQHSFF
DYRK1_Spur      ------RRAGEPGHTVSDPHKFKDPILRMLEYDPASRIKPYYALQHSFF
AqueK110_Aque   ------LRKGDSGHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHPFF
AqueK111_Aque   ------LRKGDSGHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHPFF
GK031_Glam      ELIRNPVMTQYEGHTSADYEEFEEFLSKILVYDPKRRWTIDEALNSRFL
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