mnb_Dmel MHHHS-------------------------------------------------------
DYRK1B_Mmus MAVPP-------------------------------------------------------
DYRK1A_Mmus MHTGGE----------------------TSACKPSSVRLAPSFSFH--------------
mbk-1_Cele MFPTLSS------------------VVESAACRVACPRLSPLTTLFRALSFTCDLSSVFL
DYRK1B_Hsap MAVPP-------------------------------------------------------
DYRK1A_Hsap MHTGGE----------------------TSACKPSSVRLAPSFSFH--------------
Dyrk1_Ddis MDSD--------------------------------------------------------
DYRK1_Spur MTIDHVRHYRLYMQHLKDRKRRSLNGCDDVYCL--TEQLNGDMSVH--------------
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque MDGSSS----------------------DS------------------------------
GK031_Glam M-----------------------------------------------------------
mnb_Dmel -------------------------------------------SPSS-------------
DYRK1B_Mmus -----------------------------------------GHGPFSGF----P---GPQ
DYRK1A_Mmus ------------------------------AAGLQMAAQMPHSHQYSDRRQ-------PS
mbk-1_Cele FASPMNFYRFINNCSGTTCFFLENMNTADVPDNLQSWGQQPSSS-YSNTQQHSQMTNLPP
DYRK1B_Hsap -----------------------------------------GHGPFSGF----P---GPQ
DYRK1A_Hsap ------------------------------AAGLQMAGQMPHSHQYSDRRQ-------PN
Dyrk1_Ddis ------------------------------------------------------------
DYRK1_Spur ------------------------------CSSTQLNGQPAATHPASGSQETPT---GPN
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque ------------------------------------SLQQHHSHSSSD------------
GK031_Glam ------------------------------------------------------------
mnb_Dmel ------------------------------------------SSEVRAMQARIP------
DYRK1B_Mmus -------------------------------------EHTQVLPDVRLLPRRLP------
DYRK1A_Mmus ISDQQVS-ALP------------------YSDQIQQPLTNQVMPDIVMLQRRMP------
mbk-1_Cele INHNNLCDTEPMNEDFQLQDVQADELQKQQKQQEQ-QHIQQQNAQRFIAQSRQPHSNILR
DYRK1B_Hsap -------------------------------------EHTQVLPDVRLLPRRLP------
DYRK1A_Hsap ISDQQVS-ALS------------------YSDQIQQPLTNQVMPDIVMLQRRMP------
Dyrk1_Ddis ------------------------------------------------------------
DYRK1_Spur VA-------------------------------HREPILQQQAEEMAAMQSRIP------
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque ------------------------------------------------------------
GK031_Glam ------------------------------------------------------------
mnb_Dmel ------------------------------------------------------------
DYRK1B_Mmus ------------------------------------------------------------
DYRK1A_Mmus ------------------------------------------------------------
mbk-1_Cele FPQPPITSIKTNSHAFYPQQEVTQVRPKKHRVSMTNAEAALTPGMPPEKQAAKKRNIGQF
DYRK1B_Hsap ------------------------------------------------------------
DYRK1A_Hsap ------------------------------------------------------------
Dyrk1_Ddis ------------------------------------------------------------
DYRK1_Spur ------------------------------------------------------------
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque ------------------------------------------------------------
GK031_Glam ------------------------------------------------------------
mnb_Dmel -------------------------NHFREPASGPLRKLSVDLIKTYKHINEVYYAKKKR
DYRK1B_Mmus -------------------------LAFRDAASAPLRKLSVDLIKTYKHINEVYYAKKKR
DYRK1A_Mmus -------------------------QTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKR
mbk-1_Cele STDTVPAGIGMIGIPFESTSKPLQIQQFRNPQDAPVRKLTSDLIKTYKAINESFYLRKQV
DYRK1B_Hsap -------------------------LAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKR
DYRK1A_Hsap -------------------------QTFRDPATAPLRKLSVDLIKTYKHINEVYYAKKKR
Dyrk1_Ddis ---------------------------AKSRNDAPIIKLSIDLIKTYKHINQVYYTAKAK
DYRK1_Spur -------------------------HTFRDATHAPLRKLSIDLIKTYKHINEVYYAKKKR
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque ---------------------------PRQQHVSVVKKLTVDLIKTYRTINEVYYKKRRI
GK031_Glam -------------------------------SGRPIIALTLDIEKTYRGIHGLTS---KL
mnb_Dmel RAQQTQGDDDSSNK----------------------------------------------
DYRK1B_Mmus RAQQAPPQ-DSSTK----------------------------------------------
DYRK1A_Mmus RHQQGQGD-DSSHK----------------------------------------------
mbk-1_Cele RRDRHKSQ-DAGKPKGS-------------------------------------------
DYRK1B_Hsap RAQQAPPQ-DSSNK----------------------------------------------
DYRK1A_Hsap RHQQGQGD-DSSHK----------------------------------------------
Dyrk1_Ddis KKQQAQQQA-QQQA-QQLQQQAQQQQHQLQQQQQLLQQQQQQQQQQQQQQQQQQQQQQQQ
DYRK1_Spur RALPAQGD-DTSHK----------------------------------------------
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque SDRTDQSNGAGASS----------------------------------------------
GK031_Glam RTGVNQPQ-MASMR----------------------------------------------
mnb_Dmel ------------------------------------------------------------
DYRK1B_Mmus ------------------------------------------------------------
DYRK1A_Mmus ------------------------------------------------------------
mbk-1_Cele ------------------------------------------------------------
DYRK1B_Hsap ------------------------------------------------------------
DYRK1A_Hsap ------------------------------------------------------------
Dyrk1_Ddis QQQQQQYQQQHNNNINNNNNNSNINNKNNNNNNTNFNTSNNNNNTNNNSNNNSNNNNSNN
DYRK1_Spur ------------------------------------------------------------
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque ------------------------------------------------------------
GK031_Glam ------------------------------------------------------------
mnb_Dmel ------------------------------------------------------------
DYRK1B_Mmus ------------------------------------------------------------
DYRK1A_Mmus ------------------------------------------------------------
mbk-1_Cele -------------------------------------------------KDGSGASLTDT
DYRK1B_Hsap ------------------------------------------------------------
DYRK1A_Hsap ------------------------------------------------------------
Dyrk1_Ddis NNNNNNINNINNININNKNNNNNNNNNNNINNINNNNNKNNNNNNNNNNNDDN-------
DYRK1_Spur ------------------------------------------------------------
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque ------------------------------------------------------------
GK031_Glam ------------------------------------------------------------
mnb_Dmel ------------------------------------------------------------
DYRK1B_Mmus ------------------------------------------------------------
DYRK1A_Mmus ------------------------------------------------------------
mbk-1_Cele FSIHNAIPITSSDNH---------------------------------------------
DYRK1B_Hsap ------------------------------------------------------------
DYRK1A_Hsap ------------------------------------------------------------
Dyrk1_Ddis --------------NNINNNNSNNNNNNNNNNNNNNNNNNNNNNNNNSNNNNNNNNLNNN
DYRK1_Spur ------------------------------------------------------------
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque ------------------------------------------------------------
GK031_Glam ------------------------------------------------------------
mnb_Dmel ----------------------------------------------KERKLYNDGYDDDN
DYRK1B_Mmus ----------------------------------------------KEKKVLNHGYDDDN
DYRK1A_Mmus ----------------------------------------------KERKVYNDGYDDDN
mbk-1_Cele -----YQQDAHQNAPPLLDTNAPPTSTMVVPMRTETDLQQQQRQKSSRGGPYNNGYDDQN
DYRK1B_Hsap ----------------------------------------------KEKKVLNHGYDDDN
DYRK1A_Hsap ----------------------------------------------KERKVYNDGYDDDN
Dyrk1_Ddis NSNNNYN-------------------------NNTTTTSSSNNNNNNKQSKYNDGYDDEN
DYRK1_Spur ----------------------------------------------KEKRLYNDGYDDDN
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque ----------------------------------------------SRRSIKSEQYDDEN
GK031_Glam ----------------------------------------------PQ--------TDDR
mnb_Dmel HDYIIKNGEKFLDRYEI--DSLIGKGSFGQVVKAYDHEEQCHVAIKIIKNKKPFLNQAQI
DYRK1B_Mmus HDYIVRSGERWLERYEI--DSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQI
DYRK1A_Mmus YDYIVKNGEKWMDRYEI--DSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI
mbk-1_Cele YDYILKNGEIFDKRYVILSDTPVGKGSFGQVTKAYDTLNKEEVAIKIIKNKKTFFDQAQI
DYRK1B_Hsap HDYIVRSGERWLERYEI--DSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQI
DYRK1A_Hsap YDYIVKNGEKWMDRYEI--DSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQI
Dyrk1_Ddis ADYIVRIGEVFVDRFEI--ISSLGKGSFGQVVKAFDSVLKEYVAIKIIKNKVPFYNQALI
DYRK1_Spur YDYIIKNGEKWNDRYEI--DSLIGKGSFGQVAKAYDHQEQEYVAIKIIKNKKPFLNQAQI
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque HDYKVKPGERWLDRYEI--DSLIGKGSFGQVVKAFDLEEREWVAIKVIKNKRAFYQQALI
GK031_Glam GYLIVRINDCFNGRYCA--ERPLGQGSFGRVVLAKDTVNNAYVAIKIMKAGKLFTHKGRE
mnb_Dmel EVKLLEMMNRADAENKYYIVKLKRHFMWRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLT
DYRK1B_Mmus ELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLT
DYRK1A_Mmus EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLT
mbk-1_Cele EIHLLELTNAHDKDNKYNIVTLKGHFVHRAHLCLVFELLSYNLYDLLKNTSFRGVSLNLA
DYRK1B_Hsap ELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLT
DYRK1A_Hsap EVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLT
Dyrk1_Ddis EIRLLELMNNKDPEDQYKIIKLKHHFKFRNHLCIVTELLSYNLYDLLRNTHFHGVSLNLI
DYRK1_Spur EVRLLELMNKHDADSKYYIVKLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLT
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque EKRLLELLNSRDPEGKYYIVSLKRSFTFRGHLCFVFELLSYNLYELLRNTNFRGVSLNLT
GK031_Glam EAEIMSLLSDEDPPISCKF---IESFMQGNHYCIVMEALGSNLYHLLKSTKMQGFPLQTI
mnb_Dmel RKFAQQLCTALLFLSTPELNIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIY
DYRK1B_Mmus RKLAQQLCTALLFLATPELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIY
DYRK1A_Mmus RKFAQQMCTALLFLATPELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIY
mbk-1_Cele RKFAQQLGKTLLFLSSPELSIIHCDLKPENVLL--VNAKRSQIRVIDFGSSCQTGH-RIY
DYRK1B_Hsap RKLAQQLCTALLFLATPELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIY
DYRK1A_Hsap RKFAQQMCTALLFLATPELSIIHCDLKPENILL--CNPKRSAIKIVDFGSSCQLGQ-RIY
Dyrk1_Ddis KKFAHQILTALFFMSTPEVDVIHCDLKPENILL--RNPKRSAIKIIDFGSSCHSNE-RMY
DYRK1_Spur RKFAQQMCTALLFLATPELNIIHCDLKPENILL--CNPKRSAIKIIDFGSSCQLGQ-RIY
AqueK110_Aque ------------------------------------------------------------
AqueK111_Aque RKFAQQLCTALLFLSTHDINVIHCDLKPENILL--CNPKRSAIRIVDFGSSCQVGS-RMF
GK031_Glam RVWARKYLTSFKKLQHESIRIIHTDCKPENTLIPFNNTCVEDIRIVDFGSAVRYPEGQMF
mnb_Dmel HYIQSRFYRSPEVLLGIQYDLAIDMWSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGM
DYRK1B_Mmus QYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMSRIVEVLGI
DYRK1A_Mmus QYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGI
mbk-1_Cele QYIQSRFYRSPEVLLGIAYDTKIDMWSLGCILVEMHTGEPLFAGSSEVDQMMKIVEVLGM
DYRK1B_Hsap QYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGI
DYRK1A_Hsap QYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGI
Dyrk1_Ddis KYIQSRFYRSPEILLELEYSFSIDMWSLGCILVEMHVGEPLFSGQNEQDQLTKIIEVLDL
DYRK1_Spur QYIQSRFYRSPEVLLGISYDMAIDMWSLGCILVEMHTGEPLFSGSNELDQMNKIIEVLGM
AqueK110_Aque --------------------------------------------------MSKIVEVLGI
AqueK111_Aque QYIQSRFYRSPEVLLGIPYDLAIDMWSLGCILVEMHTGEPLFSGKDEIDQMSKIVEVLGI
GK031_Glam LYIQSRYYRAPEVLLLQPYDYQIDIWSIAAILFEMHTGKVLFPAKSSEILCYMMVDILGY
::::*.
mnb_Dmel PPKYLLD-QAHK-----TRKFFDKIVADGSYVLKKNQNGRK--YKPPGSRKLHDILGVET
DYRK1B_Mmus PPAPMLE-QAPK-----ARKYFERL-PGGGWTLRRTKELRKD-YQGPGTRRLQEVLGVQT
DYRK1A_Mmus PPAHILD-QAPK-----ARKFFEKL-PDGTWSLKKTKDGKRE-YKPPGTRKLHNILGVET
mbk-1_Cele PPKEMLD-IGPK-----THKYFDKT-EDGIYYCKKTRDGYRHTYKAPGARKLHEILGVTS
DYRK1B_Hsap PPAAMLD-QAPK-----ARKYFERL-PGGGWTLRRTKELRKD-YQGPGTRRLQEVLGVQT
DYRK1A_Hsap PPAHILD-QAPK-----ARKFFEKL-PDGTWNLKKTKDGKRE-YKPPGTRKLHNILGVET
Dyrk1_Ddis PPSHMID-SSPK-----AKKFFTKDPINSTYQLKKNEKLKT--NVEFCKKKLSEIIGVET
DYRK1_Spur PPNHIIE-QAPK-----AHKYFIKT--EKTWVLKRSRDGKK--YKSPRTRKLQDILGVEL
AqueK110_Aque PPPHVLE-RSAR-----RDRFFERE-SGGTWVLKRQRDGRKDHHRRPGSRSLYEVLGGDK
AqueK111_Aque PPPHVLE-RSAR-----RDRFFERE-SGGTWVLKRQRDGRKDHHRRPGSRSLYEILGGDK
GK031_Glam PPKEMIMDEEQKQISNSLKRYFKMRKQEDAELFHLNENAFP-HQVVPDSYLLNKSVIEMA
** :: : ::* : .. * . :
mnb_Dmel GGPGGR--------------RLDEPGHSVSDYLKFKDLILRMLDFDPKTRVTPYYALQHN
DYRK1B_Mmus GGPGGR--------------RAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHG
DYRK1A_Mmus GGPGGR--------------RAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHS
mbk-1_Cele GGPGGR--------------RLGEPGHSVEDYSKFKDLIKRMLQFDPKQRISPYYVVRHP
DYRK1B_Hsap GGPGGR--------------RAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHG
DYRK1A_Hsap GGPGGR--------------RAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHS
Dyrk1_Ddis GGPQSR--------------RKNEPGHALVDYLKFLDLIEKMLIYDPQKRITPLEALQHS
DYRK1_Spur GGPGGR--------------RAGEPGHTVSDPHKFKDPILRMLEYDPASRIKPYYALQHS
AqueK110_Aque GGPGGL--------------RKGDSGHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHP
AqueK111_Aque GGPGGL--------------RKGDSGHTPNDYYKFRDLVLQMLDYDPETRIKPLAALKHP
GK031_Glam EAQKERIFGRPLRELIRNPVMTQYEGHTSADYEEFEEFLSKILVYDPKRRWTIDEALNSR
. **: * .* : : ::* ::* * .:.
mnb_Dmel FFKRTADEATNTSGAGA---TANAGAGGS-GSSGAGGSS---------------------
DYRK1B_Mmus FFRRTADEATNTGPAGSSASTSPAP-LDT-CPSSSTASS---------------------
DYRK1A_Mmus FFKKTADEGTNTSN---SVSTSPAM-EQS-QSSGTTSST---------------------
mbk-1_Cele FLKQKEERVPSQPPVSHSNLQQQQQ-LYIQQPSSQMSQV---------------------
DYRK1B_Hsap FFRRTADEATNTGPAGSSASTSPAP-LDT-CPSSSTASS---------------------
DYRK1A_Hsap FFKKTADEGTNTSN---SVSTSPAM-EQS-QSSGTTSST---------------------
Dyrk1_Ddis FFLTDE-TSQPPQQQSQQQSQQQSQ-QQS-QQQSQQQ-----------------------
DYRK1_Spur FFKRTADGSTNTSN---STSASPAM-DQA-GSPPAEHSS---------------------
AqueK110_Aque FFRKEARLSQSSENGSQYSSTTPTQ-TIG-LTSSSSQPIDSFVISQEIVAMETNHTHPPP
AqueK111_Aque FFRKEARLSQSSENGSQYSSTTPTQ-TIG-LTSSSSQPIDSFVISQEIVAMETNHTHPPP
GK031_Glam F-----------------------------------------------------------
*
mnb_Dmel -----------------------GGGVGGGLGASNSSSGAVSSSSAAAPTAATAAATAAG
DYRK1B_Mmus -----------------------ISSSGGSSGSSNDN------RA-------YRYS----
DYRK1A_Mmus -----------------------SSSSGGSSGTSNSG------RARSDPTHQ--------
mbk-1_Cele -----------------------MESPSVGSVYVEDN------GM-------YRQA----
DYRK1B_Hsap -----------------------ISSSGGSSGSSSDN------RT-------YRYS----
DYRK1A_Hsap -----------------------SSSSGGSSGTSNSG------RARSDPTHQ--------
Dyrk1_Ddis -------------------------SQ--------QR------RQS-NTD--NNFS----
DYRK1_Spur -----------------------GSSSGGATGGSNNGSGTGG-RAQSDPTHQNSTS----
AqueK110_Aque GLGELIPGRHIHLQNLSPPETHDASLYGGNNGRGVVG------SSGTLGS--GTFS----
AqueK111_Aque GLGELIPGRHIHLQNLSPPETHDTSLYGGNNGRGVVG------SSGTLGS--GTFS----
GK031_Glam ------------------------------------------------------------
mnb_Dmel SSGSGSSVGGG-S-SAAQQ------QQ---------------------AMPLPL-PLPLP
DYRK1B_Mmus ----NRYCGG---P--GPP------ITDC-------------------EMNSPQVLPSQP
DYRK1A_Mmus ----HRHSGGH--FAAAVQ------AMDC-------------------ETHSPQVRQQFP
mbk-1_Cele -------PGSSANPISVTSSFDEGDAMEVDAGRRRFSAHQQNYHNPNYQYSQPQQQQQQQ
DYRK1B_Hsap ----NRYCGG---P--GPP------ITDC-------------------EMNSPQVPPSQP
DYRK1A_Hsap ----HRHSGGH--FTAAVQ------AMDC-------------------ETHSPQVRQQFP
Dyrk1_Ddis ----NNN--------P---------IN--------------NYNSPSS--KSPHQQLQQ-
DYRK1_Spur ----NHALGHQ-HPGSSAG------AMDY-------------------ESMSSHSSLT--
AqueK110_Aque ----N--SGS---FGSAM---------D---------------------IGQPQQPVA--
AqueK111_Aque ----N--SGS---FGSAM---------D---------------------IGQPQQPVA--
GK031_Glam ------------------------------------------------------------
mnb_Dmel LP-PLAGPGGASDGQCHGLLMHSVAANAMNNFSALSLQSNAHPPPSLANSHHSTNSLGSL
DYRK1B_Mmus LR-PWAG---------------------------------GDV-----------------
DYRK1A_Mmus APLGWSG---------------------------------TEAPTQVTVETHPVQ--ETT
mbk-1_Cele YQ-QTQ---------------------------------------RTQLEQQQK---QAQ
DYRK1B_Hsap LR-PWAG---------------------------------GDV-----------------
DYRK1A_Hsap APLGWSG---------------------------------TEAPTQVTVETHPVQ--ETT
Dyrk1_Ddis ------------------------------------------------------------
DYRK1_Spur -S-GMSS---------------------------------GDVA----------------
AqueK110_Aque ----------------------------------------------MTM-----------
AqueK111_Aque ----------------------------------------------MTM-----------
GK031_Glam ------------------------------------------------------------
mnb_Dmel NHISPGSTGCHNNNSNSSNNNTRHSRLYGSNMVNMVGHHNSGSSNNHNSISYPHAMECDP
DYRK1B_Mmus ---------------------P---------------HKTHQA-----------------
DYRK1A_Mmus FHVAPQQNALHHHHGNSSHHHHHHHHH---------HHHHGQQALGNRT--RPRVYNS--
mbk-1_Cele LQQQLQQQQMQQQQ--QQQQQRQHMPQ---------AQSSSQQHLQSRA--RPRQQDQ--
DYRK1B_Hsap ---------------------P---------------HKTHQA-----------------
DYRK1A_Hsap FHVAPQQNALHHHHGNSSHHHHHHHHH---------HHHHGQQALGNRT--RPRVYNS--
Dyrk1_Ddis ----------------QQQQQ-QQQQQ---------QQQQQQQQQQQQQ--Q--QTYS--
DYRK1_Spur --FASSSSSAHGHSSSHTYPHPHSHSR---------KHHHHHSSHG-HS--L----PS--
AqueK110_Aque -------------EASSSLHQ-VTGSH---------RPHSGRKGEGGER--K--GGPS--
AqueK111_Aque -------------EASSSLHQ-VTGSH---------RPHSGRKGEGGER--K--RGPS--
GK031_Glam ------------------------------------------------------------
mnb_Dmel PQMPPPPPNGHGRMRVPAIMQLQPNSYAPNSVPYYGNMSSSSVAAAAAAAAAAASHLMMT
DYRK1B_Mmus ---------------------------------------P-----------ISASTL---
DYRK1A_Mmus ------------------------------------PTN--------------SSST---
mbk-1_Cele ------------------------------------NE-W-----------RNQFEL---
DYRK1B_Hsap ---------------------------------------P-----------ASASSL---
DYRK1A_Hsap ------------------------------------PTN--------------SSST---
Dyrk1_Ddis ------------------------------------PTT--------------QQSN---
DYRK1_Spur ------------------------------------PAAP-----------ASNVNL---
AqueK110_Aque ------------------------------------PNA--------------SLHN---
AqueK111_Aque ------------------------------------PNA--------------SLHN---
GK031_Glam ------------------------------------------------------------
mnb_Dmel DSSVISASAAGGGQGGGNPGQNPVTPSAAAFLFPSQPAGTLYGTALGSLSDLPLPMPLPM
DYRK1B_Mmus --------PGTGAQLPPLPRCLGRPPSPTSP-----------------------PPPELM
DYRK1A_Mmus ---------QDSMEV---------------------------------------------
mbk-1_Cele ---------DDTFQQ---------------------------------------------
DYRK1B_Hsap --------PGTGAQLPPQPRYLGRPPSPTSP-----------------------PPPELM
DYRK1A_Hsap ---------QDSMEV---------------------------------------------
Dyrk1_Ddis ---------HKLVDQ--MKKASMKDKSPHSN-----------------------------
DYRK1_Spur --------SQTVLQAPIV--TMGIPTIPVTM-----------------------GMPHVH
AqueK110_Aque ---------GGGVQV---------------------------------------------
AqueK111_Aque ---------GGGVQV---------------------------------------------
GK031_Glam ------------------------------------------------------------
mnb_Dmel SVPLQLPP----------------------SSSSSVS---------SGS---ASVGSGGV
DYRK1B_Mmus DVSL--------------------------------------------------------
DYRK1A_Mmus --------GHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDV
mbk-1_Cele --------KQ------RKVDDSVSNQISRN----Q-------------------------
DYRK1B_Hsap DVSL--------------------------------------------------------
DYRK1A_Hsap --------GHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQNRPVAANTLDFGQNGAMDV
Dyrk1_Ddis -ISNILN----------DSEEDN-SKVHINSNTSDNMQARINFQVENQSNIYNNNNN---
DYRK1_Spur QAGIVTTPGYVYSSHSSLENT-QSSSLSSGSL---------NMPMGAYAIPTHHHPSSTT
AqueK110_Aque --------FYGTNSLFPQSSDSNFSFQMSPSSSSKGRGAHVPHHVTEREGVRTRSGA---
AqueK111_Aque --------FYGTNSLFPQSSDSNFSFQMSPSSSSKGGGAHVPHHVTEREGVRTRSGA---
GK031_Glam ------------------------------------------------------------
mnb_Dmel GVGVVGQRRH---------------ITGPAAQV-GISQSVGSGSS------GSATGASSS
DYRK1B_Mmus ----VGSPPD---------------CSPPPPAP-APQHPAASALR-TRMTGGRPPLPPPD
DYRK1A_Mmus NLTVYSNPRQ---------------ETGIAGHP-TYQFSANTGPA-HYMTEGHLAMRQGA
mbk-1_Cele -----------------------------------------FNPQQVSMTHGNVNANNRE
DYRK1B_Hsap ----VGGPAD---------------CSPPHPAP-APQHPAASALR-TRMTGGRPPLPPPD
DYRK1A_Hsap NLTVYSNPRQ---------------ETGIAGHP-TYQFSANTGPA-HYMTEGHLTMRQGA
Dyrk1_Ddis ----NNNNNN--------------------------NNNNNNNS-NNYNNSNE---LSPN
DYRK1_Spur QQTLVNNPHLHGTTTGTGGIALTSNVSGATSVPYAFALPVQSAVS-----TGLVNS-QTT
AqueK110_Aque ----GPNSRN---------------QKSYRHHH---HHHRRTHPS-----EG---GASGS
AqueK111_Aque ----GSNSRN---------------QKSYRHHH-HHHHHRRTHPS-----EG---GASGS
GK031_Glam ------------------------------------------------------------
mnb_Dmel DASSSSPMV-GV-CVQQNPVVIH
DYRK1B_Mmus DPATLGPRL-GLHGVPQSTAASS
DYRK1A_Mmus D-REESPMT-GV-CVQQSPVASS
mbk-1_Cele MEK------------LDYPNNKL
DYRK1B_Hsap DPATLGPHL-GLRGVPQSTAASS
DYRK1A_Hsap D-REESPMT-GV-CVQQSPVASS
Dyrk1_Ddis P-----PILPNLKDLLPHNNNNI
DYRK1_Spur RQADDSPMV-GV-CVQQSPVASH
AqueK110_Aque HDDQGGSMV-GV-------TVHQ
AqueK111_Aque HDDQGGSMV-GV-------TVHQ
GK031_Glam --------------------LSH