Protein (view, download) , Domain (view, download)
rl_Dmel          MEEFNSS-----------------------------------------------------
ERK2_Mmus        MAAAAAA-----------------------------------------------------
ERK1_Mmus        MAAAAAA-----------------------------------------------------
mpk-1_Cele       MPTWIPN-----------------------------------------------------
SMK1_Scer        MNCTLTD-----------------------------------------------------
SLT2_Scer        MADKIER-----------------------------------------------------
KSS1_Scer        MART--------------------------------------------------------
FUS3_Scer        MPKR--------------------------------------------------------
Erk2_Hsap        MAAAAAA-----------------------------------------------------
Erk1_Hsap        MAAAAAQ-----------------------------------------------------
YKL161C_Scer     MATDTER-----------------------------------------------------
ERK1_Spur        ------------------------------------------------------------
CC1G_02007_Ccin  MQRRS-------------------------------------------------------
AqueK118_Aque    MATVKPP-----------------------------------------------------
AqueK119_Aque    MATNSFA-----------------------------------------------------
AqueK120_Aque    MATNSFA-----------------------------------------------------
ERK-p2-2_Smoe    MSKGGLKWPIRSVVLGWGQRRNSGESDCGVERRKWGGGVFRVPGATRTPRPRKQGMQQSE
ERK-Un_Smoe      MSLAAAR-----------------------------------------------------
ERK5_b_Smoe      QSGVA-------------------------------------------------------
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    MAETE-------------------------------------------------------
ERK-p1_b-1_Smoe  MAQKVDP-----------------------------------------------------
ERK7_Smoe        MSEDVD------------------------------------------------------
ERK5_a-1_Smoe    MAETE-------------------------------------------------------
ERK5_c_Smoe      ------------------------------------------------------------
ERK-p2-1_Smoe    MQQSEAM-----------------------------------------------------
ERK-p1_a-1_Smoe  MATKMDP-----------------------------------------------------
ERK-p1_b-2_Smoe  MAQKVDP-----------------------------------------------------
GK037_Glam       MPLAVF------------------------------------------------------


rl_Dmel          --G---SVV-----------NG--------------------------------------
ERK2_Mmus        ------------------------------------------------------------
ERK1_Mmus        --P---GGG-----------GGE---------------------PRGT------------
mpk-1_Cele       --N---LCAQPTTRNAKPPSNGHPQATQQQSAPGSLAYRNSSNIPNGATNHVRQQKWQYT
SMK1_Scer        --N---TRAI----------NV--------------------------------------
SLT2_Scer        ------------------------------------------------------------
KSS1_Scer        ------------------------------------------------------------
FUS3_Scer        ------------------------------------------------------------
Erk2_Hsap        --G---A-----------------------------------------------------
Erk1_Hsap        --G---GGG------------GE---------------------PRRT------------
YKL161C_Scer     ------------------------------------------------------------
ERK1_Spur        ------------------------------------------------------------
CC1G_02007_Ccin  ------------------------------------------------------------
AqueK118_Aque    ------------------------------------------------------------
AqueK119_Aque    --S---CSE-----------E---------------------------------------
AqueK120_Aque    --S---CSE-----------E---------------------------------------
ERK-p2-2_Smoe    AMEAAAAAA-----------EGN------------------------F------------
ERK-Un_Smoe      --L---MIS---------------------------------------------------
ERK5_b_Smoe      ------------------------------------------------------------
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    ------------------------------------------------------------
ERK-p1_b-1_Smoe  --------------------P---------------------------------------
ERK7_Smoe        ------------------------------------------------------------
ERK5_a-1_Smoe    ------------------------------------------------------------
ERK5_c_Smoe      ------------------------------------------------------------
ERK-p2-1_Smoe    --EAAAAAA-----------EGN------------------------F------------
ERK-p1_a-1_Smoe  --------------------P---------------------------------------
ERK-p1_b-2_Smoe  --------------------P---------------------------------------
GK037_Glam       ------------------------------------------------------------


rl_Dmel          ----------TGSTEV--PQSN--------------------------------------
ERK2_Mmus        ---------------------G--------------------------------------
ERK1_Mmus        ----------AGVVPV--VPGE--------------------------------------
mpk-1_Cele       RSGHRKMADGEAVI-S--TVNN--------------------------------------
SMK1_Scer        ----------ASNLG---APQQ--------------------------------------
SLT2_Scer        ---------------------H--------------------------------------
KSS1_Scer        ------------------------------------------------------------
FUS3_Scer        ------------------------------------------------------------
Erk2_Hsap        ---------------------G--------------------------------------
Erk1_Hsap        ----------EGVGPG--VPGE--------------------------------------
YKL161C_Scer     ---------------------C--------------------------------------
ERK1_Spur        ------------------------------------------------------------
CC1G_02007_Ccin  ------------------------------------------------------------
AqueK118_Aque    ------------------------------------------------------------
AqueK119_Aque    --------------------DG--------------------------------------
AqueK120_Aque    --------------------DG--------------------------------------
ERK-p2-2_Smoe    ----------TGVLVH--SGRY--------------------------------------
ERK-Un_Smoe      -----------GAVRRGGIEFRVILVQGFGWKLQLQACTRSAASSGMVRSRFETRCLLHW
ERK5_b_Smoe      ------------------------------------------------------------
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    ------------------------------------------------------------
ERK-p1_b-1_Smoe  -----------GGIAH--PGKH--------------------------------------
ERK7_Smoe        ------------------------------------------------------------
ERK5_a-1_Smoe    ------------------------------------------------------------
ERK5_c_Smoe      ------------------------------------------------------------
ERK-p2-1_Smoe    ----------TGVLVH--SGRY--------------------------------------
ERK-p1_a-1_Smoe  -----------NGYCP--PDKH--------------------------------------
ERK-p1_b-2_Smoe  -----------GGIAH--PGKH--------------------------------------
GK037_Glam       ------------------------------------------------------------


rl_Dmel          ------------------AEVIRGQIFEVGPRYI-KLAYIGEGAYGMVVSADD--TL--T
ERK2_Mmus        ------------------PEMVRGQVFDVGPRYT-NLSYIGEGAYGMVCSAYD--NL--N
ERK1_Mmus        ------------------VEVVKGQPFDVGPRYT-QLQYIGEGAYGMVSSAYD--HV--R
mpk-1_Cele       ------------------VEEVHGQLFEVAPRYV-NLSYIGEGAYGMVASALD--TI--T
SMK1_Scer        ------------------RTIFAKERISIPGYYE-IIQFLGKGAYGTVCSVKFKGRS--P
SLT2_Scer        ------------------TFKVFNQDFSVDKRFQ-LIKEIGHGAYGIVCSARF--AEAAE
KSS1_Scer        ------------------------ITFDIPSQYK-LVDLIGEGAYGTVCSAIH--KP--S
FUS3_Scer        ------------------------IVYNISSDFQ-LKSLLGEGAYGVVCSATH--KP--T
Erk2_Hsap        ------------------PEMVRGQVFDVGPRYT-NLSYIGEGAYGMVCSAYD--NV--N
Erk1_Hsap        ------------------VEMVKGQPFDVGPRYT-QLQYIGEGAYGMVSSAYD--HV--R
YKL161C_Scer     ------------------IFRAFGQDFILNKHFH-LTGKIGRGSHSLICSSTY--TESNE
ERK1_Spur        --------------------------FDVGLLYT-ELEAIAQGALALCSSAVD--TR--H
CC1G_02007_Ccin  -------------------FTALNSVFCVDAQYE-FVKELGQGAYGCVVAARH--RQ--T
AqueK118_Aque    ------------------PEIVRGQAFDVGPRYS-NLSYIGEGAYGMVCSAVD--NQ--S
AqueK119_Aque    ------------------VLVLPGHYWRVGKRYK-DLEYLALGGNGLVCKAID--TY--T
AqueK120_Aque    ------------------VLVLPGHYWRVGKRYK-DLEYLALGGNGLVCKALD--TY--T
ERK-p2-2_Smoe    -----------------VQYNIFGNLFEVTAKYVPPIRPIGRGAYGIVCSAVN--SE--T
ERK-Un_Smoe      PWRSIRRSKFPKIWHRFRCFHAWISCRAVGPRYL-LHEHIGSGSYGDVCRATD--CQ--A
ERK5_b_Smoe      ---------------------NFITEYGEAQRYK-VLEVIGKGSYGVVCSAID--TR--T
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    ----------------------FFTEYGEASRYK-ILEVIGKGSYGVVCSATD--MH--T
ERK-p1_b-1_Smoe  ------------------YYMLWRSLFEIDQRYA-PIKPIGKGAYGVVCSATN--SE--S
ERK7_Smoe        --------------------------KHVLRKYH-VCQKLGKGAYGIVWKAFD--RK--T
ERK5_a-1_Smoe    ----------------------FFTEYGEASRYK-ILEVIGKGSYGVVCSATD--MH--T
ERK5_c_Smoe      ---------------------NFITEYGEAQRYK-VLEVIGKGSYGVVCSAID--TR--T
ERK-p2-1_Smoe    -----------------VQYNIFGNLFEVTAKYVPPIRPIGRGAYGIVCSAVN--SE--T
ERK-p1_a-1_Smoe  ------------------YYMLWHSLFEIDTKYV-PIRPLGKGAYGVVCSADN--LE--T
ERK-p1_b-2_Smoe  ------------------YYMLWRSLFEIDQRYA-PIKPIGKGAYGVVCSATN--SE--S
GK037_Glam       --------------------NIKGTRFCVPDYYK-VTKALGAGAYGVVAEAVD--TR--T


rl_Dmel          NQRVAIKKISP-FEHQTYCQRTLREITILTRFK-HE-----NIIDIRDI--LRVDSI---
ERK2_Mmus        KVRVAIKKISP-FEHQTYCQRTLREIKILLRFR-HE-----NIIGINDI--IRAPTI---
ERK1_Mmus        KTRVAIKKISP-FEHQTYCQRTLREIQILLRFR-HE-----NVIGIRDI--LRAPTL---
mpk-1_Cele       RDRVAIKKISP-FEHQTFCQRTLREIKILNRFK-HE-----NIINIQEI--IRSETV---
SMK1_Scer        AARIAVKKISNIFNKEILLKRAIRELKFMNFFKGHK-----NIVNLIDL--EIV-TS---
SLT2_Scer        DTTVAIKKVTNVFSKTLLCKRSLRELKLLRHFRGHK-----NITCLYDMDIVFYP-D---
KSS1_Scer        GIKVAIKKIQ-PFSKKLFVTRTIREIKLLRYFHEHE-----NIISILDK--VRPVSI---
FUS3_Scer        GEIVAIKKIE-PFDKPLFALRTLREIKILKHFK-HE-----NIITIFNI--QRPDSF---
Erk2_Hsap        KVRVAIKKISP-FEHQTYCQRTLREIKILLRFR-HE-----NIIGINDI--IRAPTI---
Erk1_Hsap        KTRVAIKKISP-FEHQTYCQRTLREIQILLRFR-HE-----NVIGIRDI--LRASTL---
YKL161C_Scer     ETHVAIRKIPNAFGNKLSCKRTLRELKLLRHLRGHP-----NIVWLFDTDIVFYP-N---
ERK1_Spur        GGKVAIKKISP-FEHQTYCQRTLREIKILTRFN-HE-----NIINIQDI--IKADTI---
CC1G_02007_Ccin  GEGCAIKKITNINTKRILTKRCLREIRLLHHFRGHK-----NITCLYDMDIVFQP-N---
AqueK118_Aque    LTKVAIKRITP-FEHQTYCQRTLREIKILTRFR-HE-----NIIGILDI--LKPPSM---
AqueK119_Aque    DKRVVISKRDSLF-SKTYCQRDLRELQVISRLQ-KALGDDLPIPELIDI--VCEPANQPI
AqueK120_Aque    DKRVVLSKRDSLF-SKTYCQRDLRELQVLSRLQ-KALGDDLPLPELLDL--VCEPANQPL
ERK-p2-2_Smoe    NEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMD-HE-----NIVAIRDI--IRPPSK---
ERK-Un_Smoe      SLTVALKRVGDVLCCPLLAKRVLREVCIMRRLS-HR-----YVITLTDV--FISMSME-V
ERK5_b_Smoe      NEKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DVVEIKHI--LLPPSR---
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    GDKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DIVEIKHI--MLPPSR---
ERK-p1_b-1_Smoe  GEKVAIKKITNAFENTTDARRTLREIRLLRHLY-HE-----NIIGIKDI--MKPVGR---
ERK7_Smoe        NDVVALKKIFDAFQNSTDAQRTFREVMFLQEINDHE-----NVIKLTNV--LKA---E--
ERK5_a-1_Smoe    GDKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DIVEIKHI--MLPPSR---
ERK5_c_Smoe      NEKVAIKKINDIFEHVSDATRILREIKLLRLLR-HP-----DVVEIKHI--LLPPSR---
ERK-p2-1_Smoe    NEEVAIKKIGNAFDNRIDAKRTLREIKLLRHMD-HE-----NIVAIRDI--IRPPSK---
ERK-p1_a-1_Smoe  GDKVAIKKIGNAFENSIDALRTLREMRLLRYLQ-HE-----NVVGLLDI--MKPVGR---
ERK-p1_b-2_Smoe  GEKVAIKKITNAFENTTDARRTLREIRLLRHLY-HE-----NIIGIKDI--MKPVGR---
GK037_Glam       NTTVAIKKISNLFVHLVDSKRTLREITILRMLD-HE-----NIVKLLDV--LVPEDP---


rl_Dmel          DQMRDVYIVQCLMET-DLYKLLKT-Q----RLSNDHICYFLYQILRGLKYIHSANVLHRD
ERK2_Mmus        EQMKDVYIVQDLMET-DLYKLLKT-Q----HLSNDHICYFLYQILRGLKYIHSANVLHRD
ERK1_Mmus        EAMRDVYIVQDLMET-DLYKLLKS-Q----QLSNDHICYFLYQILRGLKYIHSANVLHRD
mpk-1_Cele       DSLKDIYIVQCLMET-DLYKLLKT-Q----KLSNDHVCYFLYQILRGLKYIHSANVLHRD
SMK1_Scer        SPYDGLYCYQELIDY-DLAKVIHSSV----QLSEFHIKYFLYQILCGLKYIHSADVIHRD
SLT2_Scer        GSINGLYLYEELMEC-DMHQIIKSGQ----PLTDAHYQSFTYQILCGLKYIHSADVLHRD
KSS1_Scer        DKLNAVYLVEELMET-DLQKVINNQNSGFSTLSDDHVQYFTYQILRALKSIHSAQVIHRD
FUS3_Scer        ENFNEVYIIQELMQT-DLHRVISTQ-----MLSDDHIQYFIYQTLRAVKVLHGSNVIHRD
Erk2_Hsap        EQMKDVYIVQDLMET-DLYKLLKT-Q----HLSNDHICYFLYQILRGLKYIHSANVLHRD
Erk1_Hsap        EAMRDVYIVQDLMET-DLYKLLKS-Q----QLSNDHICYFLYQILRGLKYIHSANVLHRD
YKL161C_Scer     GALNGVYLYEELMEC-DLSQIIRSEQ----RLEDAHFQSFIYQILCALKYIHSANVLHCD
ERK1_Spur        EAMRDVYIVQSLMET-DLYKLLKT-Q----PLSNDHICYFLYQILRGLKYIHSANVLHRD
CC1G_02007_Ccin  GNFDEVYLYEELMEA-DLHAIIRSGQ----PLTDAHFQSFIYQTLCGLKYIHSANVLHRD
AqueK118_Aque    AEMKDVYIVQTLMET-DLYKLLKT-Q----HLSNDHICYFLYQILRGLKYIHSANVLHRD
AqueK119_Aque    GEGTKFYVVQEAKEG-TIEIILQADQ----LPSPEQVKILMYQLLRALKLFHSAGIIHRC
AqueK120_Aque    GEGTKFYVVQEAKEG-TLELLLQADQ----LPSPEQVKLLMYQLLRALKLFHSAGLLHRC
ERK-p2-2_Smoe    DEFNDVYIVYELMDT-DLHQIIRSNQ----QLTDDHCQYFLYQLLRGLKYVHSANVLHRD
ERK-Un_Smoe      SGGIDLYIATEFADGGDMYHL---RE----PLTPEHVKFLMWQLLTGMSYIHSCRVWHRD
ERK5_b_Smoe      REFKDIYVVFELMES-DLHQVIKAND----DLMPEHYQFFLYQLLRGLKFIHTANVFHRD
ERK-p1_a-2_Smoe  ---------------------------------------------RGLKYIHSANVLHRD
ERK5_a-2_Smoe    REFKDIYVVFELMES-DLHQVIKAND----DLTPEHYQFFLYQLLRALKYIHTANVFHRD
ERK-p1_b-1_Smoe  SSFNDVYLVYELMDT-DLHQIIRSSQ----ALTDDHCQYFIYQLLRGLKYVHSANVLHRD
ERK7_Smoe        -NDRDLYLVFEYMET-DLHAVIRAN-----ILEDVHKQYIMYQLFKSLKYLHSAGLLHRD
ERK5_a-1_Smoe    REFKDIYVVFELMES-DLHQVIKAND----DLTPEHYQFFLYQLLRALKYIHTANVFHRD
ERK5_c_Smoe      REFKDIYVVFELMES-DLHQVIKAND----DLMPEHYQFFLYQLLRGLKFIHTANVFHRD
ERK-p2-1_Smoe    DEFNDVYIVYELMDT-DLHQIIRSNQ----QLTDDHCQYFLYQLLRGLKYVHSANVLHRD
ERK-p1_a-1_Smoe  YTFNDVYLVYELMDT-DLHQIIRSSQ----PLTDEHYQFFIYQLLRGLKYIHSANVLHRD
ERK-p1_b-2_Smoe  SSFNDVYLVYELMDT-DLHQIIRSSQ----ALTDDHCQYFIYQLLRGLKYVHSANVLHRD
GK037_Glam       SNFDDLYVVFDFMQT-DMHKIISSKQ----DLSPDHMQYFVYQLLRGLKYLHSANCVHRD
                                                               .:. .* .   *

rl_Dmel          LKPSNLLLNKTCDLKICDFGLARIADPE------------------HDHTGFLTEY-VAT
ERK2_Mmus        LKPSNLLLNTTCDLKICDFGLARVADPD------------------HDHTGFLTEY-VAT
ERK1_Mmus        LKPSNLLINTTCDLKICDFGLARIADPE------------------HDHTGFLTEY-VAT
mpk-1_Cele       LKPSNLLLNTTCDLKICDFGLARVTDPQ------------------TDHTGFLTEY-VAT
SMK1_Scer        LKPGNILCTLNGCLKICDFGLARGIHAGFFKC-------------HSTVQPHITNY-VAT
SLT2_Scer        LKPGNLLVNADCQLKICDFGLARGYSEN-----------------PVENSQFLTEY-VAT
KSS1_Scer        IKPSNLLLNSNCDLKVCDFGLARCLASSS-DSR-------------ETLVGFMTEY-VAT
FUS3_Scer        LKPSNLLINSNCDLKVCDFGLARIIDESAADNS----------E-PTGQQSGMTEY-VAT
Erk2_Hsap        LKPSNLLLNTTCDLKICDFGLARVADPD------------------HDHTGFLTEY-VAT
Erk1_Hsap        LKPSNLLINTTCDLKICDFGLARIADPE------------------HDHTGFLTEY-VAT
YKL161C_Scer     LKPKNLLVNSDCQLKICNFGLSCSYSENH-----------------KVNDGFIKGY-ITS
ERK1_Spur        LKPSNLLLNTTCDLKICDFGLARIADPG------------------HDHTGFLTEY-VAT
CC1G_02007_Ccin  LKPGNLLVNADCELKICDFGLARGYTPGS-GTS----------R-AAGNQGFMTEY-VAT
AqueK118_Aque    LKPSNLLLNTTCDLKICDFGLARIADPE------------------QDHTGILTEY-VAT
AqueK119_Aque    IRSNDILIDADCDLRVCDFRLAAVNGIES-DP-------------NFELLRFTDSYRVEH
AqueK120_Aque    LRSNDLLLDADCDLRVCDFRLAAVNGLES-DP-------------NFELLRFTDSYRVEH
ERK-p2-2_Smoe    LKPSNLLLNANCDLKICDFGLARTTSE-----T-----------------DYMTEY-VVT
ERK-Un_Smoe      LKSENILLMADMSVKICDFGLSRSA-----------------------------EE-VVT
ERK5_b_Smoe      LKPKNVLANANCKLKICDFGLARVAFNDA-PTA-----------------IFWTDY-VAT
ERK-p1_a-2_Smoe  LKPGNLLLNANCDLKIADFGLARTGRE----KG-----------------QFMTEY-VVT
ERK5_a-2_Smoe    LKPKNILANADCKLKICDFGLARVAFNDA-PTAIFWTVSASNKGWTYLTLLFFKDY-VAT
ERK-p1_b-1_Smoe  LKPSNLLLNASCDLKICDFGLARTGSD----KG-----------------QFMTEY-VVT
ERK7_Smoe        IKPSNLLLDSDCRCKLADFGLARSVAQLK-DD--------------MGQAQVLTDY-VAT
ERK5_a-1_Smoe    LKPKNILANADCKLKICDFGLARVAFNDA-PTAIFWTVSVSNKGWTYLTLLFFKDY-VAT
ERK5_c_Smoe      LKPKNVLANANCKLKICDFGLARVAFNDA-PTA-----------------IFWTDY-VAT
ERK-p2-1_Smoe    LKPSNLLLNANCDLKICDFGLARTTSE-----T-----------------DYMTEY-VVT
ERK-p1_a-1_Smoe  LKPGNLLLNANCDLKIADFGLARTGRE----KG-----------------QFMTEY-VVT
ERK-p1_b-2_Smoe  LKPSNLLLNASCDLKICDFGLARTGSD----KG-----------------QFMTEY-VVT
GK037_Glam       LKPSNLLLNSDCALEICDLGLARLVDDHA-AKTKEL------KD-AEKHDTQMTEY-VAT
                 ::. ::*       .:.:: *:                                   :

rl_Dmel          RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSR
ERK2_Mmus        RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ
ERK1_Mmus        RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ
mpk-1_Cele       RWYRAPEIMLN-SKGYTKSIDVWSVGCILAEMLSNRPLFPGKHYLDQLNLILAVVGSPSN
SMK1_Scer        RWYRAPELLLS-NQPYSKSVDIWAVGCILAEFYARKPVFMGRDSMHQIFEIIKVLGTPDK
SLT2_Scer        RWYRAPEIMLS-YQGYTKAIDVWSAGCILAEFLGGKPIFKGKDYVNQLNQILQVLGTPPD
KSS1_Scer        RWYRAPEIMLT-FQEYTTAMDIWSCGCILAEMVSGKPLFPGRDYHHQLWLILEVLGTPSF
FUS3_Scer        RWYRAPEVMLT-SAKYSRAMDVWSCGCILAELFLRRPIFPGRDYRHQLLLIFGIIGTPHS
Erk2_Hsap        RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ
Erk1_Hsap        RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ
YKL161C_Scer     IWYKAPEILLN-YQECTKAVDIWSTGCILAELLGRKPMFEGKDYVDHLNHILQILGTPPE
ERK1_Spur        RWYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGVLGSPSQ
CC1G_02007_Ccin  RWYRAPEIMLS-FANYSTAIDVWSVGCILAELLGGRPIFKGRDYVDQLNQILHYLGTPSE
AqueK118_Aque    RWYRAPEIMLN-SKGYSKAIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILNVIGSPTE
AqueK119_Aque    LHYWAPEVLIN--EEITPVVDIWSAGCIFAELLTGKKVFGSSDVRGQLDLIVDLLGAPSP
AqueK120_Aque    LHYWAPEVLLN--EELTPVVDLWSAGCLFAELLTGKKVFGSSDVRGQLDLLVDLLGAPSP
ERK-p2-2_Smoe    RWYRAPELLLN-CSEYTAAIDVWSVGCIFMELLNREPLFPGRDYVQQLRLITELIGSPED
ERK-Un_Smoe      PSYRAPEVIMS-RGQYSSSIDIWSLGCIFWVSVSSNDI-----TILNLDVIFNVIGTPGW
ERK5_b_Smoe      RWYRAPELCGSFFSRYTPAIDIWSIGCIFAETITRKPLFPGKNVTHQLELITDLLGTPSQ
ERK-p1_a-2_Smoe  RWYRAPELLLS-CEDYTSAIDIWSVGCIFAELLGRKPIFPGKNYINQLKLIIDVIGSPKE
ERK5_a-2_Smoe    RWYRAPELCGSFFSKYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSA
ERK-p1_b-1_Smoe  RWYRAPELLLS-CEEYTSAIDMWSVGCIFAELLGRKPIFPGKDYIHQLKLIINTIGSPEE
ERK7_Smoe        RWYRAPEILLG-STNYTFGVDMWSSGCILGELLNGKPVFPGASTMNQIEKVLDLIGKPAS
ERK5_a-1_Smoe    RWYRAPELCGSFFSKYTPAIDIWSIGCIFAEILTGKPLFPGKNVVHQLDLMTDMLGTPSA
ERK5_c_Smoe      RWYRAPELCGSFFSRYTPAIDIWSIGCIFAETITRKPLFPGKNVTHQLELITDLLGTPSQ
ERK-p2-1_Smoe    RWYRAPELLLN-CSEYTAAIDVWSVGCIFMELLNREPLFPGRDYVQQLRLITELIGSPED
ERK-p1_a-1_Smoe  RWYRAPELLLS-CEDYTSAIDIWSVGCIFAELLGRKPIFPGKNYINQLKLIIDVIGSPKE
ERK-p1_b-2_Smoe  RWYRAPELLLS-CEEYTSAIDMWSVGCIFAELLGRKPIFPGKDYIHQLKLIINTIGSPEE
GK037_Glam       RWYRAPEIILG-WPQYGKPVDIFSVGCIFAELIARKPLFPGRDYIHQLHLILEVLGTPEK
                   * ***:           :*::: **::      . :        ::  :   :* *

rl_Dmel          -DDLECIINEKARNYLE--SLPFK-PNVPWAKLFPNA--DALALDLLGKMLTFNPHKRIP
ERK2_Mmus        -EDLNCIINLKARNYLL--SLPHK-NKVPWNRLFPNA--DSKALDLLDKMLTFNPHKRIE
ERK1_Mmus        -EDLNCIINMKARNYLQ--SLPSK-TKVAWAKLFPKS--DSKALDLLDRMLTFNPNKRIT
mpk-1_Cele       -ADLQCIINDKARSYLI--SLPHK-PKQPWARLYPGA--DPRALDLLDKMLTFNPHNRID
SMK1_Scer        -DILIKFGTIKAWNLGKNSNNPVY-KKIPWSNIFPFA--SHEAINLIESLLHWDSTHRLN
SLT2_Scer        -ETLRRIGSKNVQDYIH--QLGFI-PKVPFVNLYPNA--NSQALDLLEQMLAFDPQKRIT
KSS1_Scer        -EDFNQIKSKRAKEYIA--NLPMR-PPLPWETVWSKTDLNPDMIDLLDKMLQFNPDKRIS
FUS3_Scer        DNDLRCIESPRAREYIK--SLPMY-PAAPLEKMFPRV--NPKGIDLLQRMLVFDPAKRIT
Erk2_Hsap        -EDLNCIINLKARNYLL--SLPHK-NKVPWNRLFPNA--DSKALDLLDKMLTFNPHKRIE
Erk1_Hsap        -EDLNCIINMKARNYLQ--SLPSK-TKVAWAKLFPKS--DSKALDLLDRMLTFNPNKRIT
YKL161C_Scer     -ETLQEIASQKVYNYIF--QFGNI-PGRSFESILPGA--NPEALELLKKMLEFDPKKRIT
ERK1_Spur        -DDLKCIINEKARAYLQ--GLPFK-SKIPLKSLFPKA--DNKALDFLERMLSFNPDKRIT
CC1G_02007_Ccin  -DTLRRVGSPRAQDYIR--SLPIR-PRISFSTLFPQA--NPLAIDLLSRMLCFDPARRIS
AqueK118_Aque    -KDLSCIRNEKAKSYLK--NLPFK-PTVPWSRLYPKA--DPKALDILGKMLTFNPDERIS
AqueK119_Aque    -EDLAFVKGDASRTALT--SVQN-SSP-TFEERFKNI--DPVARDLLKKMLVFNPSQRIT
AqueK120_Aque    -EDLAFVKGDASRTALT--SVQN-SSP-TFEERFKNL--DPVARDLLKKMLVFNPSQRLT
ERK-p2-2_Smoe    -ADLGFLRNDNARRYVR--QLQRY-PRQSFAHRFPNV--PPLAVDLVERMLVFNPQNRIS
ERK-Un_Smoe      -SDIESVPSESWRSYLK--HLPGR-VRNLTEQLLGYV--DQEALDLLFRMLAFNPGRRCT
ERK5_b_Smoe      -DVISRVRNEKARRYLS--TMSKK-SPVPFSEKFKNI--DPLARNLLQKMLAFDPKDRPS
ERK-p1_a-2_Smoe  -SQLGFISNHKARSYIR--SLPPT-PRVPLSRLYPHA--NPQALQLIERMLAFDPKERIT
ERK5_a-2_Smoe    -ESVARVRNEKARRYLS--GMRKK-TAIPFTQKFPNA--DPLALRLLERLLAFDPKDRPT
ERK-p1_b-1_Smoe  -DDLQFILSNKARSYIR--SLPFA-PKIPLERLYPRA--NPLALNLIDQMLVFDPKKRLT
ERK7_Smoe        -EDIAAFESPFAAAMIE--NMAITGPSRSFRKAFPSA--TPEAADLLRKLLHFNPQKRLT
ERK5_a-1_Smoe    -ESVARVRNEKARRYLS--GMRKK-TAIPFTQKFPNA--DPLALRLLERLLAFDPKDRPT
ERK5_c_Smoe      -DVISRVRNEKARRYLS--TMSKK-SPVPFSEKFKNI--DPLARNLLQKMLAFDPKDRPS
ERK-p2-1_Smoe    -ADLGFLRNDNARRYVR--QLQRY-PRQSFAHRFPNV--PPLAVDLVERMLVFNPQNRIS
ERK-p1_a-1_Smoe  -SQLGFISNHKARSYIR--SLPPT-PRVPLSRLYPHA--NPQALQLIERMLAFDPKERIT
ERK-p1_b-2_Smoe  -DDLQFILSNKARSYIR--SLPFA-PKIPLERLYPRA--NPLALNLIDQMLVFDPKKRLT
GK037_Glam       -ELLDRIASDSAKSYVL--ALKPS-APQDLSQKFPML--DEAGIDLLTRMLTLDPLKRIT
                    .  .                                      ::  :*  :.  *

rl_Dmel          VEE-------------------ALAHPYLEQYYDPGDEPVA------EVP----------
ERK2_Mmus        VEQ-------------------ALAHPYLEQYYDPSDEPIA------EAP----------
ERK1_Mmus        VEE-------------------ALAHPYLEQYYDPTDEPVA------EEP----------
mpk-1_Cele       IEQ-------------------ALAHPYLEQYYDPGDEPVC------EEP----------
SMK1_Scer        VEQ-------------------AISHPFLNEVRKPDDEPVCL-----QGP----------
SLT2_Scer        VDE-------------------ALEHPYLSIWHDPADEPVCS--E----K----------
KSS1_Scer        AAE-------------------ALRHPYLAMYHDPSDEPEYP--PL---N----------
FUS3_Scer        AKE-------------------ALEHPYLQTYHDPNDEPEGE--PIPPSF----------
Erk2_Hsap        VEQ-------------------ALAHPYLEQYYDPSDEPIA------EAP----------
Erk1_Hsap        VEE-------------------ALAHPYLEQYYDPTDEPVA------EEP----------
YKL161C_Scer     VED-------------------ALEHPYLSMWHDIDEEFSCQ--K----T----------
ERK1_Spur        VEE-------------------ALAHPYLEQYYDPDDEVTV------IEQ----------
CC1G_02007_Ccin  CEE-------------------ALNHPYLAVWHDPADEPNCD--S----I----------
AqueK118_Aque    VDA-------------------ALAHPYLEQYYDPDDEPVA------EVP----------
AqueK119_Aque    AEK-------------------ALEHEYLAEYHDPSEEPVYN--A--EKPLWKELLVSDQ
AqueK120_Aque    AEK-------------------ALEHEYLAEYHDPSEEPVYN--A--EKPLWKELLVSDQ
ERK-p2-2_Smoe    VTE-------------------ALAHPYLTNLHDVNDEPSCH------GP----------
ERK-Un_Smoe      AEE-------------------ALSHIYVSNRL----------------Y----------
ERK5_b_Smoe      ATEVKYSLTSEQVMLTRELDFQALADPYFQSMSHLQREPAAN--P--ISR----------
ERK-p1_a-2_Smoe  VSE-------------------ALDHPYFNLVHDNHAGDVYQFRPDNIIP----------
ERK5_a-2_Smoe    AEE-------------------ALADPYFRGLAKVEREPSAQ--P--ITK----------
ERK-p1_b-1_Smoe  VTD-------------------ALEHPYLSMLHDAALEPSAS------AA----------
ERK7_Smoe        AEQ-------------------ALQHPYVAQFHNPREEPSCN--R--L------------
ERK5_a-1_Smoe    AEE-------------------ALADPYFRGLAKVEREPSAQ--P--ITK----------
ERK5_c_Smoe      ATE-------------------ALADPYFQSMSHLQREPAAN--P--ISR----------
ERK-p2-1_Smoe    VTE-------------------ALAHPYLTNLHDVNDEPSCH------GP----------
ERK-p1_a-1_Smoe  VSE-------------------ALDHPYFNLVHDNHAGDVYQFRPDNIIP----------
ERK-p1_b-2_Smoe  VTD-------------------ALEHPYLSMLHDAALEPSAS------AA----------
GK037_Glam       VNE-------------------CLSHPYFEGIHDESDEPVYT--G---QP----------
                                       .: . :.

rl_Dmel          ------------------------------------------------------------
ERK2_Mmus        ------------------------------------------------------------
ERK1_Mmus        ------------------------------------------------------------
mpk-1_Cele       ------------------------------------------------------------
SMK1_Scer        ------------------------------------------------------------
SLT2_Scer        ------------------------------------------------------------
KSS1_Scer        ------------------------------------------------------------
FUS3_Scer        ------------------------------------------------------------
Erk2_Hsap        ------------------------------------------------------------
Erk1_Hsap        ------------------------------------------------------------
YKL161C_Scer     ------------------------------------------------------------
ERK1_Spur        ------------------------------------------------------------
CC1G_02007_Ccin  ------------------------------------------------------------
AqueK118_Aque    ------------------------------------------------------------
AqueK119_Aque    NLEVLRSQLLKEVHELKAWLMGPEVEAPLVNGHPWHVGSRYRNLEFLTKGSNGSMCFATD
AqueK120_Aque    NLEVLRSQLIKEVHEIKAWLMGPEVEAPIVNGHPWHVGSRYRNLEFLTKGSNGSMCFATD
ERK-p2-2_Smoe    ------------------------------------------------------------
ERK-Un_Smoe      ------------------------------------------------------------
ERK5_b_Smoe      ------------------------------------------------------------
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    ------------------------------------------------------------
ERK-p1_b-1_Smoe  ------------------------------------------------------------
ERK7_Smoe        ------------------------------------------------------------
ERK5_a-1_Smoe    ------------------------------------------------------------
ERK5_c_Smoe      ------------------------------------------------------------
ERK-p2-1_Smoe    ------------------------------------------------------------
ERK-p1_a-1_Smoe  ------------------------------------------------------------
ERK-p1_b-2_Smoe  ------------------------------------------------------------
GK037_Glam       ------------------------------------------------------------


rl_Dmel          ------------------------------------------------------------
ERK2_Mmus        ------------------------------------------------------------
ERK1_Mmus        ------------------------------------------------------------
mpk-1_Cele       ------------------------------------------------------------
SMK1_Scer        ------------------------------------------------------------
SLT2_Scer        ------------------------------------------------------------
KSS1_Scer        ------------------------------------------------------------
FUS3_Scer        ------------------------------------------------------------
Erk2_Hsap        ------------------------------------------------------------
Erk1_Hsap        ------------------------------------------------------------
YKL161C_Scer     ------------------------------------------------------------
ERK1_Spur        ------------------------------------------------------------
CC1G_02007_Ccin  ------------------------------------------------------------
AqueK118_Aque    ------------------------------------------------------------
AqueK119_Aque    TRTSSRVVLSKRDGLYSQEYSKRNLRELQLLTRLQRMYSDDYDPFPRLLDFLCYPQNLSG
AqueK120_Aque    TRTSSRVVISKRDGLYSQEYSKRNLREIQILTRLQRMYSDDYDPFPRIIDFICYPQNLSG
ERK-p2-2_Smoe    ------------------------------------------------------------
ERK-Un_Smoe      ------------------------------------------------------------
ERK5_b_Smoe      ------------------------------------------------------------
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    ------------------------------------------------------------
ERK-p1_b-1_Smoe  ------------------------------------------------------------
ERK7_Smoe        ------------------------------------------------------------
ERK5_a-1_Smoe    ------------------------------------------------------------
ERK5_c_Smoe      ------------------------------------------------------------
ERK-p2-1_Smoe    ------------------------------------------------------------
ERK-p1_a-1_Smoe  ------------------------------------------------------------
ERK-p1_b-2_Smoe  ------------------------------------------------------------
GK037_Glam       ------------------------------------------------------------


rl_Dmel          ------------------------------------------------------------
ERK2_Mmus        ------------------------------------------------------------
ERK1_Mmus        ------------------------------------------------------------
mpk-1_Cele       ------------------------------------------------------------
SMK1_Scer        ------------------------------------------------------------
SLT2_Scer        ------------------------------------------------------------
KSS1_Scer        ------------------------------------------------------------
FUS3_Scer        ------------------------------------------------------------
Erk2_Hsap        ------------------------------------------------------------
Erk1_Hsap        ------------------------------------------------------------
YKL161C_Scer     ------------------------------------------------------------
ERK1_Spur        ------------------------------------------------------------
CC1G_02007_Ccin  ------------------------------------------------------------
AqueK118_Aque    ------------------------------------------------------------
AqueK119_Aque    PKQAELYVVQTAFDVNLADLLNQQRMTHDQLWCLMYSLLVSLKLLHSAGVVHRCLRPRHL
AqueK120_Aque    PKQAELYVVQTAFDVNLADILNQQRMTHDQIWCIMYSLLVSLKLLHSAGVVHRCIRPRHL
ERK-p2-2_Smoe    ------------------------------------------------------------
ERK-Un_Smoe      ------------------------------------------------------------
ERK5_b_Smoe      ------------------------------------------------------------
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    ------------------------------------------------------------
ERK-p1_b-1_Smoe  ------------------------------------------------------------
ERK7_Smoe        ------------------------------------------------------------
ERK5_a-1_Smoe    ------------------------------------------------------------
ERK5_c_Smoe      ------------------------------------------------------------
ERK-p2-1_Smoe    ------------------------------------------------------------
ERK-p1_a-1_Smoe  ------------------------------------------------------------
ERK-p1_b-2_Smoe  ------------------------------------------------------------
GK037_Glam       ------------------------------------------------------------


rl_Dmel          ------------------------------------------------------------
ERK2_Mmus        ------------------------------------------------------------
ERK1_Mmus        ------------------------------------------------------------
mpk-1_Cele       ------------------------------------------------------------
SMK1_Scer        ------------------------------------------------------------
SLT2_Scer        ------------------------------------------------------------
KSS1_Scer        ------------------------------------------------------------
FUS3_Scer        ------------------------------------------------------------
Erk2_Hsap        ------------------------------------------------------------
Erk1_Hsap        ------------------------------------------------------------
YKL161C_Scer     ------------------------------------------------------------
ERK1_Spur        ------------------------------------------------------------
CC1G_02007_Ccin  ------------------------------------------------------------
AqueK118_Aque    ------------------------------------------------------------
AqueK119_Aque    LLTSEFDLALCDLRRSLMNHEPCGEEYNWTGSSTEGSWQYLSPQAVCYDEQTTACDLWSA
AqueK120_Aque    LLTSEFDLAICDLRRSIMNHEPCGEEYNWTGSSTEGSWQYLSPQAVCYDEQTTACDIWSA
ERK-p2-2_Smoe    ------------------------------------------------------------
ERK-Un_Smoe      ------------------------------------------------------------
ERK5_b_Smoe      ------------------------------------------------------------
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    ------------------------------------------------------------
ERK-p1_b-1_Smoe  ------------------------------------------------------------
ERK7_Smoe        ------------------------------------------------------------
ERK5_a-1_Smoe    ------------------------------------------------------------
ERK5_c_Smoe      ------------------------------------------------------------
ERK-p2-1_Smoe    ------------------------------------------------------------
ERK-p1_a-1_Smoe  ------------------------------------------------------------
ERK-p1_b-2_Smoe  ------------------------------------------------------------
GK037_Glam       ------------------------------------------------------------


rl_Dmel          ------------------------------------------------------------
ERK2_Mmus        ------------------------------------------------------------
ERK1_Mmus        ------------------------------------------------------------
mpk-1_Cele       ------------------------------------------------------------
SMK1_Scer        ------------------------------------------------------------
SLT2_Scer        ------------------------------------------------------------
KSS1_Scer        ------------------------------------------------------------
FUS3_Scer        ------------------------------------------------------------
Erk2_Hsap        ------------------------------------------------------------
Erk1_Hsap        ------------------------------------------------------------
YKL161C_Scer     ------------------------------------------------------------
ERK1_Spur        ------------------------------------------------------------
CC1G_02007_Ccin  ------------------------------------------------------------
AqueK118_Aque    ------------------------------------------------------------
AqueK119_Aque    GCVFGEMLLGQPLFVSDANAVNLFRVLFSTLGRPKDQELAFVTSRLGLQVLKELKLNESP
AqueK120_Aque    GCVFGEMLLGQPLFVSDANAVNIFRVIFSTLGRPKDQELAFVTSRIGLQVLKELKINESP
ERK-p2-2_Smoe    ------------------------------------------------------------
ERK-Un_Smoe      ------------------------------------------------------------
ERK5_b_Smoe      ------------------------------------------------------------
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    ------------------------------------------------------------
ERK-p1_b-1_Smoe  ------------------------------------------------------------
ERK7_Smoe        ------------------------------------------------------------
ERK5_a-1_Smoe    ------------------------------------------------------------
ERK5_c_Smoe      ------------------------------------------------------------
ERK-p2-1_Smoe    ------------------------------------------------------------
ERK-p1_a-1_Smoe  ------------------------------------------------------------
ERK-p1_b-2_Smoe  ------------------------------------------------------------
GK037_Glam       ------------------------------------------------------------


rl_Dmel          ---------------------------------------------------------FRI
ERK2_Mmus        ---------------------------------------------------------FKF
ERK1_Mmus        ---------------------------------------------------------FTF
mpk-1_Cele       ---------------------------------------------------------FTL
SMK1_Scer        ---------------------------------------------------------FDF
SLT2_Scer        ---------------------------------------------------------FEF
KSS1_Scer        ---------------------------------------------------------LDD
FUS3_Scer        ---------------------------------------------------------FEF
Erk2_Hsap        ---------------------------------------------------------FKF
Erk1_Hsap        ---------------------------------------------------------FTF
YKL161C_Scer     ---------------------------------------------------------FRF
ERK1_Spur        ---------------------------------------------------------FNF
CC1G_02007_Ccin  ---------------------------------------------------------FDF
AqueK118_Aque    ---------------------------------------------------------FKF
AqueK119_Aque    SLDSNLRKRNVDGQVLDLLKKMLAFSPAKRLTAEEALKHPYFAKLHDPAEEPVYTGKMSS
AqueK120_Aque    SLDSNLRKRNVDGQVIDLLKKMLAFSPAKRITAEEALKHPYFAKLHDPAEEPVYTGKMSS
ERK-p2-2_Smoe    ---------------------------------------------------------FDF
ERK-Un_Smoe      ---------------------------------------------------------FAF
ERK5_b_Smoe      ---------------------------------------------------------MEF
ERK-p1_a-2_Smoe  ---------------------------------------------------------PDV
ERK5_a-2_Smoe    ---------------------------------------------------------MEF
ERK-p1_b-1_Smoe  ---------------------------------------------------------FEF
ERK7_Smoe        ---------------------------------------------------------IRI
ERK5_a-1_Smoe    ---------------------------------------------------------MEF
ERK5_c_Smoe      ---------------------------------------------------------MEF
ERK-p2-1_Smoe    ---------------------------------------------------------FDF
ERK-p1_a-1_Smoe  ---------------------------------------------------------PDV
ERK-p1_b-2_Smoe  ---------------------------------------------------------FEF
GK037_Glam       ---------------------------------------------------------LEL


rl_Dmel          NM-----------EN-DDISRDALKSLIFEETL---------------KFKERQ------
ERK2_Mmus        DM-----------EL-DDLPKEKLKELIFEETA---------------RFQPG-------
ERK1_Mmus        DM-----------EL-DDLPKERLKELIFQETA---------------RFQPGA------
mpk-1_Cele       EM-----------EF-DDLPKEKLKELIWEEAE---------------AHHRRMEAE---
SMK1_Scer        TY-----------ES-ELNSMSKLRDYLVEEVK---------------NFKTDL------
SLT2_Scer        SF-----------ES-VN-DMEDLKQMVIQEVQ---------------DFRLFVRQPLL-
KSS1_Scer        EFWKLDNKIMRPEEE-EEVPIEMLKDMLYDELM---------------------------
FUS3_Scer        DH-----------YK-EALTTKDLKKLIWNEIF---------------------------
Erk2_Hsap        DM-----------EL-DDLPKEKLKELIFEETA---------------RFQPG-------
Erk1_Hsap        AM-----------EL-DDLPKERLKELIFQETA---------------RFQPGV------
YKL161C_Scer     EF-----------EH-IE-SMAELGNEVIKEVF---------------DFRKVVRKHPI-
ERK1_Spur        SM-----------TH-VDIPKSYLKELLFQKFT---------------I-----------
CC1G_02007_Ccin  SF-----------EE-ED-SIEGMKRLIVEEVN---------------NFRAEVRAQAR-
AqueK118_Aque    EM-----------EL-DDLPKDRLKQLIYEETM---------------NFHP--------
AqueK119_Aque    EV-----------VT-DDLPTSQLRAKLLEEVH---------------L-----------
AqueK120_Aque    EV-----------VT-DDLPTSQLRAKILEEVH---------------L-----------
ERK-p2-2_Smoe    DF-----------EQ-PTFSEDNIKELIYEESL---------------TFTTADM-----
ERK-Un_Smoe      S-----------------------------------------------------------
ERK5_b_Smoe      EF-----------ER-RRLTREDVRELIYREVTHDCRFESLSTASQILEYHPQMKME---
ERK-p1_a-2_Smoe  ME-----------DQ-MVDTSSNLREYVWREMC---------------YYHPQAI-----
ERK5_a-2_Smoe    EF-----------ER-RRISKDDVRELIYREIL---------------EYHPQMLEE---
ERK-p1_b-1_Smoe  DF-----------ED-EELREDALREKVWNEMC---------------YYHPEATN----
ERK7_Smoe        PI-----------DDNHKFTIHEYRERLYAEII---------------SRKKEIRKKARE
ERK5_a-1_Smoe    EF-----------ER-RRISKDDVRELIYREIL---------------EYHPQMLEE---
ERK5_c_Smoe      EF-----------ER-RRLTREDVRELIYREIL---------------EYHPQMKME---
ERK-p2-1_Smoe    DF-----------EQ-PTFSEDNIKELIYEESL---------------TFTTADM-----
ERK-p1_a-1_Smoe  ME-----------DQ-MVDTSSNLREYVWREMC---------------YYHPQAI-----
ERK-p1_b-2_Smoe  DF-----------ED-EELREDALREKVWNEMC---------------YYHPEATN----
GK037_Glam       FF-----------EK-YELTKPLLEMCFLNEAR---------------KFHPDELKD---


rl_Dmel          ------------------------------------------------------------
ERK2_Mmus        ------------------------------------------------------------
ERK1_Mmus        ------------------------------------------------------------
mpk-1_Cele       -------AAA--------------------------------------------------
SMK1_Scer        ------------------------------------------------------------
SLT2_Scer        ---------EEQRQLQLQQQQQQQQQQQQQQQQPSDVDNGN--AAASEENYPKQMATSNS
KSS1_Scer        ------------------------------------------------------------
FUS3_Scer        ------------------------------------------------------------
Erk2_Hsap        ------------------------------------------------------------
Erk1_Hsap        ------------------------------------------------------------
YKL161C_Scer     --------SGDSPSSSLSLEDA----------IP-------QEVVQV--H-PSR--KV--
ERK1_Spur        ------------------------------------------------------------
CC1G_02007_Ccin  ---------GSA-QNH------RSTKDSDNLGIPSRDEIISSPVKEFGPH-PGH--TSN-
AqueK118_Aque    ------------------------------------------------------------
AqueK119_Aque    ------------------------------------------------------------
AqueK120_Aque    ------------------------------------------------------------
ERK-p2-2_Smoe    ------------------------------------------------------------
ERK-Un_Smoe      ------------------------------------------------------------
ERK5_b_Smoe      -------YV--------------NGNDQANFMYPSAVDQFRRQFAHLEEHYAKG----NA
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    -------YL--------------NGTDHANFMYPSAVDQFKRQFAQLEEHYGKGG---HN
ERK-p1_b-1_Smoe  ------------------------------------------------------------
ERK7_Smoe        RERSLHREM--------------SRMQ---------------------------------
ERK5_a-1_Smoe    -------YL--------------NGTDHANFMYPSAVDQFKRQFAQLEEHYGKGG---NN
ERK5_c_Smoe      -------YV--------------NGNDQANFMYPSAVDQFRRQFAHLEEHYAKG----NA
ERK-p2-1_Smoe    ------------------------------------------------------------
ERK-p1_a-1_Smoe  ------------------------------------------------------------
ERK-p1_b-2_Smoe  ------------------------------------------------------------
GK037_Glam       -------EV--------------AKRA---------------------------------


rl_Dmel          ------------------------------------------------------------
ERK2_Mmus        ------------------------------------------------------------
ERK1_Mmus        ------------------------------------------------------------
mpk-1_Cele       ------------------------------------------------------------
SMK1_Scer        ------------------------------------------------------------
SLT2_Scer        VAPQQESFGIHSQNLPRHDADFPPRPQES-------------------------------
KSS1_Scer        ------------------------------------------------------------
FUS3_Scer        ------------------------------------------------------------
Erk2_Hsap        ------------------------------------------------------------
Erk1_Hsap        ------------------------------------------------------------
YKL161C_Scer     --------------LPSY----SP------------------------------------
ERK1_Spur        ------------------------------------------------------------
CC1G_02007_Ccin  ----------YTTNA--------P------------------------------------
AqueK118_Aque    ------------------------------------------------------------
AqueK119_Aque    ------------------------------------------------------------
AqueK120_Aque    ------------------------------------------------------------
ERK-p2-2_Smoe    ------------------------------------------------------------
ERK-Un_Smoe      ------------------------------------------------------------
ERK5_b_Smoe      MVPLE----RQHASLPRLVV--------SFS--------CCIDNRGKCSSAGTTILAVPC
ERK-p1_a-2_Smoe  ------------------------------------------------------------
ERK5_a-2_Smoe    NAAVE----RHHASLPRFEA--------FLFIVNVILKRINITGRRRCT---------PA
ERK-p1_b-1_Smoe  ------------------------------------------------------------
ERK7_Smoe        ------------------------------------------------------------
ERK5_a-1_Smoe    NAAVE----RHHASLPRFEA--------FLFIVNVILKRINITGRRRCT---------PA
ERK5_c_Smoe      MVPLE----RQHASLPR-------------------------------------------
ERK-p2-1_Smoe    ------------------------------------------------------------
ERK-p1_a-1_Smoe  ------------------------------------------------------------
ERK-p1_b-2_Smoe  ------------------------------------------------------------
GK037_Glam       ------------------------------------------------------------


rl_Dmel          ------------------------------------------PDNAP
ERK2_Mmus        --------------------------------------------YRS
ERK1_Mmus        -------------------------------------------PEGP
mpk-1_Cele       -------------------------------------R-NNGGQNPV
SMK1_Scer        ------------------------------------------SSSSL
SLT2_Scer        --MME----MR-PATGNTADIPPQN-DNGTLLDLEKELEFGLDRKYF
KSS1_Scer        -------------------------------------------KTME
FUS3_Scer        ----------------------------------------------S
Erk2_Hsap        --------------------------------------------YRS
Erk1_Hsap        -------------------------------------------LEAP
YKL161C_Scer     -------------EFSYVSQLPSLT-TTQPYQNLMGIS-SNSFQGVN
ERK1_Spur        ----------------------------------------------F
CC1G_02007_Ccin  -------------------RAPSPI-MDDPSAELEREL-ASTHISKK
AqueK118_Aque    --------------------------------------------HAV
AqueK119_Aque    -----------------------------------------F-SSPQ
AqueK120_Aque    -----------------------------------------F-SSPQ
ERK-p2-2_Smoe    --------------------------------------------VTE
ERK-Un_Smoe      ------------------------------------------YKYSM
ERK5_b_Smoe      WLFLSMCY-LREQA--CRSSEESPVPIVSLFYLF--LH-ITHLFYSC
ERK-p1_a-2_Smoe  --------------------------------------------NEM
ERK5_a-2_Smoe    LLLLQVTVLARNEN--TTTRGSSRR-SLSRRSRLE-RH-RKVVTKAS
ERK-p1_b-1_Smoe  --------------------------------------------EYS
ERK7_Smoe        --------------------------------S---RR-SSYHPRAS
ERK5_a-1_Smoe    LLLLQVTVPARNEN--TTTRGSSRR-SLSRRSRLE-RH-RKVVTKAS
ERK5_c_Smoe      ----------------------------------------LVVSFSC
ERK-p2-1_Smoe    --------------------------------------------VTE
ERK-p1_a-1_Smoe  --------------------------------------------NEM
ERK-p1_b-2_Smoe  --------------------------------------------EYS
GK037_Glam       --------------------------------K---AL-GIPESVWM