Erk5_Hsap MAEPL-KEEDG------------------------EDGSAEPPGPVKAEPAHTAASVAAK
ERK5_Mmus MAEPL-KEEDG------------------------EDGSGEPPGRVKAEPVHTAASVVAK
ERK5_Spur MQ-----------------------------------------------------QAASR
AqueK121_Aque MEVHQIQTEKKPQETQKPQNSQTLDNQRLGVEEKSIPGTSEMILVRSSNSPKPSTGTSDK
* . :
Erk5_Hsap NLALLKARSFDVTFDVG-DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVT
ERK5_Mmus NLALLKARSFDVTFDVG-DEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVT
ERK5_Spur SLLAFKGRCMDVKFDIANSNYKPLEKIGTGAYGVVCSAINKKNGEKVAIKKIPNSFDELT
AqueK121_Aque RVYTIKHRSMSVKFECD-SRYTPLESIGTGAYGVVCAAKDNRTGRKVAIKKIPRAFDEVV
: :* *.:.*.*: ..* :*.**.******.:* . .*.:*******.:** :.
Erk5_Hsap NAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPL
ERK5_Mmus NAKRTLRELKILKHFKHDNIIAIKDILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPL
ERK5_Spur TAKRTFRELKILRHFRHENVIAIREILMPKEPLSEMKDVYVVFDLMESDLHQIIHSNQPF
AqueK121_Aque TAKRTYRELKILRHLRHENVISILDVMEPPENESSLQDVYVILDLMETDLHHIIHSVQPL
.**** ******:*::*:*:*:* ::: * ..::.***::****:***:**** **:
Erk5_Hsap TLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPA-E
ERK5_Mmus TLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPA-E
ERK5_Spur SLEHIRFFLYQILRGLKYIHSADVIHRDLKPSNLLVNENCELKVGDFGMARGLSTFSTDK
AqueK121_Aque SDDHIKYFLYQIGRGLKYIHSANIIHRDLKPSNLLINRNCELKIGDFGMARGLSSTPE-D
: :*:::****: *****:***::***********:*.*****:*********.: . .
Erk5_Hsap HQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQL
ERK5_Mmus HQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQL
ERK5_Spur KKMFMTSYVATRWYRAPELLFSSDDYTLAVDVWSVGCILGEMIGRKQMFPGKNPIDQLSL
AqueK121_Aque HALFLTEYVATRWYRAPELMLSFSQYDISLDMWSVGCIFAEMLGRRQIFPGKNYVNQLQL
: *:*.************::* :* ::*:******:.**:.*:*:***** :.**.*
Erk5_Hsap IMMVLGTPSPAVIQAVGAERVRAYIQ-SLPPRQPVPWETVYPGADRQALSLLGRMLRFEP
ERK5_Mmus IMMVLGTPSPAVIQAVGAERVRAYIQ-SLPPRQPVPWETVYPGADRQALSLLGRMLRFEP
ERK5_Spur IVDVLGMPPTHMLKSTSSDHLYNFFQKNFANKTPKDLSKLYPKADPQGLDLLAKMLIFEP
AqueK121_Aque VLSVVGTPSDEYINNIGSERVKTYLK-SLPKKQPVDLFVLFPKANKVALELLEKLLQLDP
:: *:* *. :: .:::: ::: .:. : * ::* *: .*.** ::* ::*
Erk5_Hsap SARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARR
ERK5_Mmus SARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARR
ERK5_Spur SERITVNKALQHPFLATYYSPDDEPDCFPKFDFSFESHVMSREQIKQQIGKMILKYNKPT
AqueK121_Aque RKRYIAIEILGHPYLSLYHDITDEPICTPPFDFTFEKTLDTKELLRSAVVDELKEYHKCR
* . * **:*: *:. *** * * ***:*: ::* ::. : : .::
Erk5_Hsap EGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPG-PA-PDTID
ERK5_Mmus EGIRQQIRFQPSLQPVASEPVCPDVEMPSPWAPSGDCAMESPPPALPPCSD-PA-PDTVD
ERK5_Spur GWV-SKGLLRPSSRRTTLETVGPSFN-KDPQGAGGEVRNDSDGDSVPPSSSSPLIRESLL
AqueK121_Aque IPI-------------------------------------------PPTNQV---RDALK
: ** :::
Erk5_Hsap LTLQPPP----PVSEPA-PPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPR
ERK5_Mmus LTLQPAP----PASELA-PPKREGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPR
ERK5_Spur SGLSQTSPLFGGLTDLS-PNSSQKTISEDTKALIKAALMN---SALKNHKKDRLGKGGGK
AqueK121_Aque KMMEEREQK---SSEGGEPEKRE-------QKEVAAVKKKRLDERKRRTPDHQIHGPE--
:. :: . * . : : : *. : . : . :
Erk5_Hsap KPVTAQERQREREEKRRRRQERA-KEREKRRQERERKERGAGASGGPSTDPLAGLVLSDN
ERK5_Mmus KPVTAQERQREREEKRRRRQERA-KEREKRRQERERKERGAGTLGGPSTDPLAGLVLSDN
ERK5_Spur MPVTALSRQREREEKRKQKIRRSMKKKKKNRHDKEEKKQ-------------PPALLTEE
AqueK121_Aque ---------------------------K------PKKKQ------------KVYSPLTDS
: .*:: *::.
Erk5_Hsap DRSLLERWTRMARPAAPALTS--------------------------------V------
ERK5_Mmus DRSLLERWTRMARPPAPA------------------------------------------
ERK5_Spur DKNMLERWNRMQQKNAAAAKS--------------------------------QDESSRR
AqueK121_Aque DRTALEHWNKLAVAVSNTTKKKGQETEEILSLQQQQELLIKQQAEQLEKQQKQMVEQQRR
*:. **:*.:: : :
Erk5_Hsap -----P------------------------------------------------------
ERK5_Mmus -----P------------------------------------------------------
ERK5_Spur VKSESD------------------------------------------------------
AqueK121_Aque IQQQSEQIRQLVHHQKVLIRECKAAGIKIPLSTPNPSPLSQAGLVSSPLTNASITTVKLT
Erk5_Hsap -----APAPAPTPTPTPVQPTSPP------------PGPVAQPTGPQPQSAGSTSGPV--
ERK5_Mmus -----APAPAPAPAPSSAQPTSTP------------TGPVSQSTGPL-QPAGSIPGPA--
ERK5_Spur -----APYEPAAKTQLPNDPKRSDV---DVVQYSTKFDPADTSSGNV-------------
AqueK121_Aque PPVQAHPLPIVKPHPFPVQPHPPPFDPGSLIRTDVPVSPVNNSTTSN-SQSSSVPPATAT
* . :* . .*. .:
Erk5_Hsap -------------PQPACPPPGPAPHPTGPPGPIPVPAPPQI---ATSTSLLAAQSLVPP
ERK5_Mmus -------------SQPVCPPPGPVPQPAGP-----IPAPLQT---APSTSLLASQSLVPP
ERK5_Spur -------------LKGLRVSATLMESPKST-----TSQANPAGSLNNHTSTTANRSQ---
AqueK121_Aque HAINYQNQPPVVAPPPTVAPPTAIAPPTSS-----ITYPLPV---PSYSTMLPTDSY-PP
.. * .. . . :: . *
Erk5_Hsap PG----LPGSSTP-------GVLPYFPPGLP--------PPDAGGAPQSSMSESPDVNLV
ERK5_Mmus SG----LPGSGAP-------EVLPYFPSGPP--------PPDPGLTPQPSTSESPDVNLV
ERK5_Spur -NPALV-----------------------------------------RRHDSTSSDITNI
AqueK121_Aque HGPPLPLPQS-PPDFMSSYIPVLPAQPSVPPDRSVPYCGPPAEF---FSPLTSKELVELT
. : . :
Erk5_Hsap TQQLSKS-------------QVEDPLPPVFS----GTPKGS-GAGYGVGFDLEEFLNQSF
ERK5_Mmus TQQLSKS-------------QVEDPLPPVFS----GTPKGS-GAGYGVGFDLEEFLNQSF
ERK5_Spur IRQLSRS-------------VVEDTLPSLLSVPLPVTPKGD-GGGYGLSLDIEELMGESL
AqueK121_Aque SQEMRKLSPYIPQSIDSFVPPLQEDLEKMFN----VPPGGTFGGGYGVGISDDELTIMVP
::: : ::: * ::. .* * *.***:.:. :*:
Erk5_Hsap DMGVADGPQDGQADSASLSASLLADWLEG-HGMNPADIESL---QREIQMDSPMLLADLP
ERK5_Mmus DMGVADGPQDGQADSASLSASLLADWLEG-HGMNPADIESL---QREIQMDSPMLLSDLP
ERK5_Spur DPNVQI---NDRCDSAPLSASLLSDWLDV-RNLNSEDIENLRDIQRELGLTSPVGIPVVP
AqueK121_Aque DNKIE----------GPPSASLLQEWLQDIDDIDSQGLQAL---QQEMEFGASEMF--FR
* : .. ***** :**: .::. .:: * *:*: : :. : .
Erk5_Hsap DL--------QDP
ERK5_Mmus DL--------QEP
ERK5_Spur PLGAAQSNRNPKL
AqueK121_Aque EL--------EKL
* .