IRAK-14_d-2_Smoe  MA--------GCLFFAIR-----KRKMK-------LID--VVAFSAN-------------
IRAK-14_b-2_Smoe  MA--------IEMAS-SRSGSSTRARMRALWVAVGLVELW-LWLTSTAHAQFVPKDNILL
IRAK-14_a-2_Smoe  M-----------------------------------------------------------
IRAK-14_e_Smoe    MRVTGTRILAAQMRI-DRGNRPISRPDHPLFFFI-VLASF-LALLGRSSAQWKPQDVFRI
IRAK-14_a-1_Smoe  MA--------ARSRL------------------A-LLGLWTVAFLARCLAQWQPRDFYRI
IRAK-14_b-1_Smoe  MA--------IEMASSSRSGSSTRARMRALWVAVGLVELW-LWLTSTAHAQFVPKDNILL
IRAK-14_d-1_Smoe  ------------------------------------------------------------


IRAK-14_d-2_Smoe  -------------------SQL--------------------------------------
IRAK-14_b-2_Smoe  ACGAAGST-NVSGRTFVADSSFAQGGAPRSGSIPTSSAANLSSADEQRLYSTARVFTPKG
IRAK-14_a-2_Smoe  ------------------------------------------------------------
IRAK-14_e_Smoe    SCGESRSDIDGNGLEWTPDAE---NPRLVAGGTPTNSTRG--TSGTSVPYRAARVFTSPA
IRAK-14_a-1_Smoe  DCGAASNT-SSGDRHWQGEPP--QSPAFASSGISINTSAQNPELPSPAPYLTARIFTARA
IRAK-14_b-1_Smoe  ACGAAGST-NVSGRTFVADSSFAQGGAPRSGSIPTSSAANLSSADEQRLYSTARVFTAKG
IRAK-14_d-1_Smoe  ------------------------------------------------------------


IRAK-14_d-2_Smoe  ------------------------------------------------------KA----
IRAK-14_b-2_Smoe  SFSIGDLTPGRHWIRLHFLPFS-P--DLAAALFSVSADEYLLLSSQSVAGEIQAQARSIS
IRAK-14_a-2_Smoe  ------------------------------------------------------------
IRAK-14_e_Smoe    SYSF-SISPGRHWVRLHFAPLA-D--ASSRARFSVAIGSRLLVANSSIAEDIAAG--NGS
IRAK-14_a-1_Smoe  NYSF-PVDPGRHWIRLHFYPFPSPGFDPALANFSITVGPYTLFSGGIVDSVRRSG--SGG
IRAK-14_b-1_Smoe  SFSIGDLTPGRHWIRLHFLPFS-P--DLAAALFSVSADEYLLLSSQSVAGEIQAQARSIS
IRAK-14_d-1_Smoe  ------------------------------------------------------------


IRAK-14_d-2_Smoe  ---------------------TPQ------------------------------------
IRAK-14_b-2_Smoe  SPALLKEYSINITTAQLTISLVPSP---GSLAFVNAIEIVSIPDAAIQDDGQLVG-QGTQ
IRAK-14_a-2_Smoe  ------------------------------------------------------------
IRAK-14_e_Smoe    -SPVVREFTIHTSGTAVAVTLTPSA---SFIAFVSGIELISMARDALSPSVVEISPEASE
IRAK-14_a-1_Smoe  -VYLVKEYSVVAEGSELAIVFQPSPSSNGSFALINGIEVMSMPEDALQDDAVLLG-QGTA
IRAK-14_b-1_Smoe  SPALLKEYSINITTAQLTISLVPSP---GSLAFVNAIEIVSIPDAAIQDDGQLVG-QGTQ
IRAK-14_d-1_Smoe  ------------------------------------------------------------


IRAK-14_d-2_Smoe  ------------------------------------------------------------
IRAK-14_b-2_Smoe  A-FLGMARAALQTMYRLNVGGESIDPSLDSG-LSRRWIRDN-PFLVGAREGIPAPK-IED
IRAK-14_a-2_Smoe  ------------------------------------------------------------
IRAK-14_e_Smoe    SRQVEIAGILARTLYRLNVGGDLIAPGNDSSSQARTWLPDE-PFLQGVARGVPVPPAVPD
IRAK-14_a-1_Smoe  T-KFGFSRLALETLYRLNVGGASVNAANDT--QQRSWVSDGHGFIEGAAAGVGSQDFSSS
IRAK-14_b-1_Smoe  A-FLGMARAALQTMYRLNVGGESIDPSLDSG-LSRRWIRDN-PFLVGAREGIPAPK-IED
IRAK-14_d-1_Smoe  ------------------------------------------------------------


IRAK-14_d-2_Smoe  ------------------------------------------------------------
IRAK-14_b-2_Smoe  ITYPPLLPGFIAPKSVYGTSRTMGVSDLINT---------------------------HT
IRAK-14_a-2_Smoe  ------------------------------------------------------------
IRAK-14_e_Smoe    IVYPATVPEYIAPRGVYGTARSLGGSNTVTNAFNISWAFSVAPGYAHYVRLHFAELVYSS
IRAK-14_a-1_Smoe  IKFTKEVPEFIAPAAVYGTGRVLGISNTVSNTFKISWSFPVSPGYSHLVRLHFAELYYTK
IRAK-14_b-1_Smoe  ITYPPLLPGFIAPKSVYGTARTMGVSDLINTQFNLTWTFAVDSGYSYFVRMHFCETVYST
IRAK-14_d-1_Smoe  ------------------------------------------------------------


IRAK-14_d-2_Smoe  --------------------------CKKGLLFLSFIVF---------------------
IRAK-14_b-2_Smoe  PYARIFDVFINRLPAVKGLDVVVKANGAQTAMFMDFVVPMNDGGSSMVVELGPSPGNGAQ
IRAK-14_a-2_Smoe  ------------------------------------------------------------
IRAK-14_e_Smoe    PMQRIFSVYINNRTAIRALDLIQQTGAANTPYYRDFLVLPVDGLANLRLQVGPLTGSNSQ
IRAK-14_a-1_Smoe  TYQRMFNVYINNRTAIDGLDLIVL-GPRFTPVYKDFVVIPSSGVRSLRVQIGPAPNSNAQ
IRAK-14_b-1_Smoe  PYARIFDVFINRLPAVKGLDVVVKANGAQTAMFMDFVVPMNDGGSSMVVELGPSPGNGAQ
IRAK-14_d-1_Smoe  ------------------------------------------------------------


IRAK-14_d-2_Smoe  ----------------------------GADI----------------------------
IRAK-14_b-2_Smoe  HNDSILSGIEIFKVNNTRGSLAGSLIPPGVDLSKDDGSSGGSTGIGAAGIGGAVAGGLLV
IRAK-14_a-2_Smoe  --------------NSTAGNLSDSD--GGESSSSSSGRSGGSKGVGA--IVGAAVGGIAL
IRAK-14_e_Smoe    VQDAILNGVEIFRLNDSSGSVDGLA---VVPRSSDSGGNGGH-HLGV--IIGCVAGGVFA
IRAK-14_a-1_Smoe  FNDAILNGLEIFKMNSTAGSLSDSD--GGESSSSSSGRSGGSKAVGA--IVGAAVGGIAL
IRAK-14_b-1_Smoe  HNDSILSGIEIFKVNNTRGSLAGSLIPPGVDLSKDDGSSGGSTGIGAAGIGGAVAGGLLV
IRAK-14_d-1_Smoe  ------------------------------------------------------------


IRAK-14_d-2_Smoe  ------------------------------------------------------------
IRAK-14_b-2_Smoe  IGLLGAGLCFVRRRRHPGLAKGKSKKKKSASWLPLHAAGNGN---------STSIASKFS
IRAK-14_a-2_Smoe  LALLAA--CVFVL-----CCRRGAKGGKKLGWRPVPASQAGT---------GTS---TVT
IRAK-14_e_Smoe    LVAIALAICFFFR-----CCKGGGKKPSTSSWQAL---GNGHPHHHHHAFSLTTLGSTMG
IRAK-14_a-1_Smoe  LALLAA--CVFVL-----CCRRGAKGGKKLGWRPVPASQAGT---------GTS---TVT
IRAK-14_b-1_Smoe  IGLLGAGLCFVRRRRHPGLAKGKSKKKKSASWLPLHAAGNGN---------STSIASKFS
IRAK-14_d-1_Smoe  ------------------------------------------------------------


IRAK-14_d-2_Smoe  ----RPADVTTIA---KDAKDSNHIRRLTLKEVVNATNCYK--TMIGEGGFGTVFYGTLS
IRAK-14_b-2_Smoe  TGGASNKSGATVA---STATSSLGGRFFTFAEILEATNNFDETLLLGVGGFGKVYRGELF
IRAK-14_a-2_Smoe  -LGFPGSSPATHYSVT----PANSCKHFSLQQIVDATDGFDDDLLLGVGGFGKVYKGEIN
IRAK-14_e_Smoe    -AGSPRSAAGSYYNAGSAASAGGHGRYFTLQEIAEATNSFDETRLLGVGGFGRVYKGEID
IRAK-14_a-1_Smoe  -LGFPGSSPATHYSAT----PANSCKHFSLQQIVDATDGFDNDLLLGVGGFGKVYKGEIN
IRAK-14_b-1_Smoe  TGGASNKSGATVA---STATSSLGGRFFTFAEILEATNNFDETLLLGVGGFGKVYRGELF
IRAK-14_d-1_Smoe  ------------------------------------------------------------


IRAK-14_d-2_Smoe  -GQ-AVAVKARSSSSIQGTREFNTELNLLSRIQHENLVPLLGFCAEDEQEILIYPYMPNG
IRAK-14_b-2_Smoe  DGT-KVAVKRGNPRSEQGLTEFQTEIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANG
IRAK-14_a-2_Smoe  GGT-KVAVKRGNPMSEQGMTEFQTEIEMLSKLRHRHLVSLIGYCDENSEMILVYDYMANG
IRAK-14_e_Smoe    NGTLEVAVKRGNPRSEQGIAEFQAEIGLLSKLRHRHLVSLIGYCDEQSEMILVYEYMARG
IRAK-14_a-1_Smoe  GGT-KVAVKRGNPMSEQGMTEFQTEIEMLSKLRHRHLVSLIGYCDENSEMILVYDYMANG
IRAK-14_b-1_Smoe  DGT-KVAVKRGNPRSEQGLTEFQTEIEMLSKLRHLHLVSLIGYCEEHCEMILVYECMANG
IRAK-14_d-1_Smoe  --------------------------------------------------------MGGG
                                                                          *  *

IRAK-14_d-2_Smoe  SLQDRLYGEGFKRKPLDWPTRLSIALGAAKGLSFLHAGGDL-SIIHRDIKSSNILLDQSM
IRAK-14_b-2_Smoe  TLRAHLYGS--DLPPLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENF
IRAK-14_a-2_Smoe  PLRGHLYGS--DAPTLSWKQRLEICIGAARGLHYLHTGAQR-AIIHRDVKTTNILLDEKF
IRAK-14_e_Smoe    PLRGHLYGTE-DLQPLPWRHRLEILVGAARGLHYLHTGA---AIIHRDVKTTNILLDEHL
IRAK-14_a-1_Smoe  PLRGHLYGS--DAPTLSWKQRLEICIGAARGLHYLHTGAQR-AIIHRDVKTTNILLDEKF
IRAK-14_b-1_Smoe  TLRAHLYGS--DLPPLSWKQRLEICIGAARGLHYLHTGAEQGTIIHRDVKTTNILLDENF
IRAK-14_d-1_Smoe  TLMEHLYGS--KS-PLDWKARVKIAVGAATALDYLHNGSDS-KIIHRDVKSTNILLDSGM
                  .*  :***   .  .* *  *:.* :*** .* :** *.    *****:*::*****. :

IRAK-14_d-2_Smoe  TAKVADFGFSKFAPQDGDSVVSLEVRGTAGYLDPEYYLTQELTVKSDVYSFGVVLLEVIC
IRAK-14_b-2_Smoe  VAKVSDFGLSKTGPSLDRTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEVLC
IRAK-14_a-2_Smoe  VAKVSDFGLSKVGPSLDHTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLMEVVC
IRAK-14_e_Smoe    VAKVSDFGLSKTGPMLDQTHVSTAVKGSFGYLDPEYFRRQQLTDKSDVYSFGVVMVEVMC
IRAK-14_a-1_Smoe  VAKVSDFGLSKVGPSLDHTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLMEVVC
IRAK-14_b-1_Smoe  VAKVSDFGLSKTGPSLDRTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEVLC
IRAK-14_d-1_Smoe  NAKVADFGLSKHVTRIDATHVTTLVKGTVGYLDPEYYASNQLTEKSDVYSFGVVLLELIC
                   ***:***:**  .  . : *:  *:*: *******:  ::** **********:.*::*

IRAK-14_d-2_Smoe  GREPLSIDRPRSEWSLVEWARPYIQDTNIEAIVDSSISSSYSP-----EAMWRVLEVAML
IRAK-14_b-2_Smoe  ARPAINPALPREQVNIAEWAMQYQRMGALEQIVDANLKGQCSQ-----ESLQKFGETAEK
IRAK-14_a-2_Smoe  ARPAINPALPRDQVSIAEWALHWQKLGRLSNIMDPRLAGDCTP-----ESLQKFGEIAER
IRAK-14_e_Smoe    ARPAIDPALPREQVNIAEWAMSAQRSGRLEEILDPTLRRPGSDEDADMASVRKVGETADK
IRAK-14_a-1_Smoe  ARPAINPALPRDQVSIAEWALHWQKLGRLSNIMDPRLAGDCTP-----ESLQKFGEIAER
IRAK-14_b-1_Smoe  ARPAINPALPREQVNIAEWAMQYQRMGALEQIVDANLKGQCSQ-----ESLQKFGETAEK
IRAK-14_d-1_Smoe  GREPLSDRVPADQYSIITWARPYLLSGSYNEVVDRNIAGRFSI-----GSMAIFANVAAK
                  .* .:.   * .: .:  **         . ::*  :    :       ::  . : *

IRAK-14_d-2_Smoe  SVQPHSSRRPSMSDIVRELEDALIIENNASQFMA-S-IDS--------------------
IRAK-14_b-2_Smoe  CLAEQGIDRPAMGDVLWNLEYALQLQEASSGDSSGMILDHSATRAGDQMEVPLRS--SAD
IRAK-14_a-2_Smoe  CLADRGSERPSIGDVLWNLEYSLQLHDAAMFHHHQRSEDGNSNLARPTPEIPRT---SSD
IRAK-14_e_Smoe    CLQENGVQRPSMGDVLWNLESALHIQEAAQRRFGRE-NGGGGGDAGGGVAAPAAGAVENG
IRAK-14_a-1_Smoe  CLADRGSERPSIGDVLWNLEYSLQLHDAAMFHHHQRSEDGNSNLARQTPEIPRT---SSD
IRAK-14_b-1_Smoe  CLAEQGIDRPAMGDVLWNLEYALQLQEASSGDSSGMILDHSATRAGDQMEVPLRS--SAD
IRAK-14_d-1_Smoe  SVARDPNERPKMSQVLRDLKEAQAFETA--------------------------------
                  .:      ** :.::: :*: :  :.

IRAK-14_d-2_Smoe  ---------NPSGLSKQFDISPAFSETMGSPDPR
IRAK-14_b-2_Smoe  HQADYHRRLGSEDDFEDASASAVFSQ-LVNPQGR
IRAK-14_a-2_Smoe  SQ--RTMMSFEENHSGDTTASVVFSQ-LVHPEGR
IRAK-14_e_Smoe    GA-TSITDDYYDGYSEDASASAVFSQ-LVNPQGR
IRAK-14_a-1_Smoe  GQ--RMMMSFEENHSEDTTASVVFSQ-LVHPEGR
IRAK-14_b-1_Smoe  HQADYHRRLGSEDDFEDASASAVFSQ-LVNPQGR
IRAK-14_d-1_Smoe  ---------------------------------M