IRAK-Un_aw_Smoe    ------------GSTFKGIL-SD--GVLVAVKKLERSSF----------------Q--SR
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    -------GRGGFASVYKGVI----DNHFVAVKYLTSSDL--------------SDK--AR
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  FSKERLLGTGGFGEVYKGTL-DD--GVVVAIKLAKLGN----------------IK--GR
IRAK-Un_da_Smoe    FSERNIIGEGGYGIVYKGAV-S--DGTMVACKYLTNK-D----------------Q--AE
IRAK-Un_dg_Smoe    FS--NLIGQGSTNRVYKGIL-SD--GMEVAVKKLKQDVSE-------------CSD--VE
IRAK-Un_dj_Smoe    ----------------------------VVIKSVE------------------SR-----
IRAK-Un_dm_Smoe    EAIGIKIAEGGFGYVYRGTL-IN--RQEVAIKVRSSTS----------------SQ--GL
IRAK-Un_ag_Smoe    YAVLDPIGSGAYSDVYHGKRRDD--GLHVALKEVHDGK-S-------------SSR----
IRAK-Un_dq_Smoe    YAVLDPIGSGAYSDVYHGKRRDD--GLHVALKEVHDGK-S-------------SSR----
IRAK-Un_dh_Smoe    FSK--CLGQGGYGSVYRGSL-ED--GNQVAVKKLQGS-----------------NQ--TS
IRAK-Un_dp_Smoe    FSENRRLGDGGFGTVYAGTL-GG-GGDVVAVKLLHRSP----------------QQ--AS
IRAK-Un_bk-2_Smoe  FNPVNLIKAGHTGDLYRGIL-DG--GLLVVVKRVDVTS-L-------------KK-----
IRAK-Un_bk-1_Smoe  FNPVNLIKAGHTGDLYRGIL-DG--GLLVVVKRVDVTS-L-------------KK-----
IRAK-Un_ck_Smoe    FNETNKIGQGGYGSVYYGYF-RD---QKLAVKRMNM-------------------Q--AT
IRAK-Un_cn_Smoe    ------------GNVFRGTL-QD--GRVVVIKKKVS------------------------
IRAK-Un_bg_Smoe    FSKECEVGCGGFGRVYRGNL-ED--GRTVAIKQASAKS----------------KQ--GQ
IRAK-Un_cj_Smoe    FNETNKIGQGGYGSVYYGYF-RD---QKLAVKRMNM-------------------Q--AT
IRAK-Un_v-2_Smoe   FSPAQMLGHGGHGTVYKGKL-PD--GRDVAVKRINHIS----------------SH--GI
IRAK-Un_de_Smoe    FT--TLVGSGAFGPVYKATP-SPSSPTRLAVKVLSSTS----------------KQ--GE
IRAK-Un_dk_Smoe    FDDSHLLGKGGFGAVYDAVL-P--DGSHLAVKRLRNEN----------------VA--ND
IRAK-Un_bv_Smoe    PPEHNLLGTGGFGKVYRGIL-PG-ENSPVAIKKMVRDS----------------HQ--GE
IRAK-Un_ay-2_Smoe  ------------------------DSHVVAVKYLTSSDL--------------SEK--AR
IRAK-Un_ay-1_Smoe  ------------------------DSHVVAVKYLTSSDL--------------SEK--AR
IRAK-Un_df_Smoe    FSENNKIGEGSYGHVYKGTL-HR---TNVAVKVLRHDS----------------WQ--GP
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------DGSEVAVKQLDLHS----------------KQ--GQ
IRAK-Un_v-1_Smoe   FSPAQMLGHGGHGTVYKGKL-PD--GRDVAVKRINHIS----------------SH--GI
IRAK-Un_bx-1_Smoe  FSDSHKLGQGGFGSVFKGTL-KN--GQHIAVKKLDTAS----------------LQ--GE
LRR10a_d-2_Smoe    FSRDAVIAMSRTGVFYKATL-RD--GSVLAVKKLRRAAM--------------HSA--GE
IRAK-Un_cz_Smoe    ------------GSTFKGIL-SD--GVLVAVKKLERSSF----------------Q--SR
IRAK-Un_e_Smoe     ----------------------------VAIKRSKSSA----------------NFGVMD
IRAK-Un_dn_Smoe    FSEENQLGQGGFGVVYKANL-K--DGTQVAVKKLSLHS----------------KQ--GK
IRAK-Un_do_Smoe    FHSLIGQGRGAASAVYRAKF-KD--GLVAAVKRFHAAP---------------QPQ--SE
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  --------------VYKGRL-DQ--NRWIAVKKFPKTAWP------------------DA
IRAK-Un_av-1_Smoe  --------------VYKGRL-DQ--NRWIAVKKFPKTAWP------------------DA
IRAK-Un_bx-2_Smoe  FSDSHKLGQGGFGSVFKGTL-KN--GQHIAVKKLDTAS----------------LQ--GE
IRAK-Un_am-1_Smoe  FSKERLLGTGGFGEVYKGTL-DD--GVVVAIKLAKLGN----------------IK--GR
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      FSSKNFIGEGGYGRVYRGVL-AKRGNSEVAVKVMKASS----------------KE--NN
IRAK-Un_bo-2_Smoe  FNPSNLIGRGRFGLVYKGLL-ED--GTIVAIKTRAS-------------------A--PT
IRAK-Un_dc_Smoe    FSENNKIGEGSYGHVYKGTL-HR---TNVAVKVLRHDS----------------WQ--GP
IRAK-Un_k-2_Smoe   FSISNKIGEGGYGAVYYGEI-RD---QKLAIKKMNM-------------------Q--AT
IRAK-Un_bo-1_Smoe  FNPSNLIGRGRFGLVYKGLL-ED--GTIVAIKTRAS-------------------A--PT
IRAK-Un_cb_Smoe    YRIVGVLGSGGVGVTYEAET-EQ--GDAVAIKAMSLRNMK-------------GWK--DL
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    FSSSNFIKAGHSGDLYRGVL-DG--GVLVVVKRIEVAK-M-------------KK-----
IRAK-Un_t_Smoe     FSSSNFIKAGHSGDLYRGVL-DG--GVLVVVKRIEVAK-M-------------KK-----
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  FAPENKLGQGGFGSVYKGVL-P--NGTIVAMKELSSKS----------------NQ--GT
IRAK-Un_bp-2_Smoe  FAPENKLGQGGFGSVYKGVL-P--NGTIVAMKELSSKS----------------NQ--GT
IRAK-Un_k-1_Smoe   FSISKKIGEGGYGAVYYGEI-RD---QKLAIKKMNM-------------------Q--AT
IRAK-Un_bd_Smoe    FSK--CLGQGGYGSVYRGSL-ED--GNQVAVKKLQGS-----------------NQ--NS
IRAK-Un_h_Smoe     FQQMPLLGAGGAGKVYKAVL-E--GGMEVAVKRIPIQPPEPPSSSDASRSSGKGSF--GK
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    FHAANKLGEGGSAVVYKGII-Q--TIGPVAIKFLQIKAH---------------SI--SN
IRAK-Un_ap-1_Smoe  FHKDNLVGRGGFASVYKGVI----DNHFVAVKYLTSSDL--------------SDK--AR
IRAK-Un_ap-2_Smoe  FHKDNLVGRGGFASVYKGVI----DNHFVAVKYLTSSDL--------------SDK--AR


IRAK-Un_aw_Smoe    KEFLAEM------------------NRIARLR-HP----SLV------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    RDFENEV------------------STICLLQ-HK----NVV------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    -----------------------------SVR-HQ----NLV------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  DQVINEV------------------RVLSQVN-HR----NLV------------------
IRAK-Un_da_Smoe    KEFLVEV------------------ETIGRVR-HK----NLV------------------
IRAK-Un_dg_Smoe    ASFRFQM------------------ELLSRVH-HQ----HLA------------------
IRAK-Un_dj_Smoe    EMFDAEV------------------AMLAGLG-HSSSANRFV------------------
IRAK-Un_dm_Smoe    REFTAEL------------------TLLSKIR-HP----NLV------------------
IRAK-Un_ag_Smoe    -EL-AAL------------------QLLTNS---S----HVV------------------
IRAK-Un_dq_Smoe    -EL-AAL------------------QLLTNS---S----HVV------------------
IRAK-Un_dh_Smoe    RDFYAEL------------------ASLARTN-HL----NLV------------------
IRAK-Un_dp_Smoe    PQFMAEI------------------DILSRFK-HP----NLV------------------
IRAK-Un_bk-2_Smoe  DFLLSEL------------------EFFSKAS-HT----RLV------------------
IRAK-Un_bk-1_Smoe  DFLLSEL------------------EFFSKAS-HT----RLV------------------
IRAK-Un_ck_Smoe    KEFLSEL------------------KILSRVH-HS----NLVFSQALYFQLTPTIIFLLQ
IRAK-Un_cn_Smoe    ---ELEL------------------DILLRIR-SA----SIV------------------
IRAK-Un_bg_Smoe    REFRNEI------------------QLLSRLH-HR----HLV------------------
IRAK-Un_cj_Smoe    KEFLSEL------------------KILSRVH-HS----NLVFSQALYFQLTPTIIFLLQ
IRAK-Un_v-2_Smoe   EQVLNEV------------------KVLLSVS-HP----NLV------------------
IRAK-Un_de_Smoe    REFQTEV------------------SLLGRLH-HK----NLV------------------
IRAK-Un_dk_Smoe    PSFEAEI------------------STLGLIK-HR----NLV------------------
IRAK-Un_bv_Smoe    REFLAEL------------------QIISKRS-HR----NLV------------------
IRAK-Un_ay-2_Smoe  LDFENEV------------------STICLLQ-HK----NVV------------------
IRAK-Un_ay-1_Smoe  LDFENEV------------------STISLLQ-HK----NVV------------------
IRAK-Un_df_Smoe    QEFEQEVRKLTRISKISNEHGKIKVEVLSRLH-HP----HIV------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     KSLVKEL------------------SLLARLH-HA----YLV------------------
IRAK-Un_bb_Smoe    REFVNEL------------------SIITSIQ-HK----NLA------------------
IRAK-Un_v-1_Smoe   EQVLNEV------------------KVLLSVS-HP----NLV------------------
IRAK-Un_bx-1_Smoe  REFMNEL------------------SIMGSMASSP----FVV------------------
LRR10a_d-2_Smoe    KHFRSEM------------------EALAKVR-HR----NLV------------------
IRAK-Un_cz_Smoe    KEFLAEM------------------NRIARLR-HP----SLV------------------
IRAK-Un_e_Smoe     EQFLNEI------------------TILSQVN-HR----NLV------------------
IRAK-Un_dn_Smoe    QEFVNEL------------------NIITGIR-HR----NLA------------------
IRAK-Un_do_Smoe    EEFKNEA------------------HFLGRLH-HR----HLV------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  RQFMDEA------------------FGVGQVR-HE----RLV------------------
IRAK-Un_av-1_Smoe  RQFMDEA------------------FGVGQVR-HE----RLV------------------
IRAK-Un_bx-2_Smoe  REFMNEL------------------SIMGSMASSP----FVV------------------
IRAK-Un_am-1_Smoe  DQVINEV------------------RVLSQVN-HR----NLV------------------
IRAK-Un_bj-2_Smoe  ------------------------------LK-HD----NLV------------------
IRAK-Un_bj-1_Smoe  ------------------------------LK-HD----NLV------------------
RKF3_a-2_Smoe      AEFLNEV------------------EVINRVR-HR----NLL------------------
IRAK-Un_bo-2_Smoe  QEFVTEV------------------VNLSQLR-HK----NVV------------------
IRAK-Un_dc_Smoe    QEFEQEVRKLTRISKISNKHGKIKVEVLSRLH-HP----HIV------------------
IRAK-Un_k-2_Smoe   REFMSEL------------------KVLTHVH-HT----NLV------------------
IRAK-Un_bo-1_Smoe  QEFVTEV------------------VNLSQLR-HK----NVV------------------
IRAK-Un_cb_Smoe    DLFEREA------------------RVLKSLQ-HS----GIP------------------
IRAK-Un_cs_Smoe    -------------------------------P-HP----NIV------------------
IRAK-Un_cu_Smoe    DLLTLEL------------------EVFGKAS-HT----RLV------------------
IRAK-Un_t_Smoe     DLLTLEL------------------EVFGKAS-HT----RLV------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  REFLNEV------------------TVISAVQ-HR----NLV------------------
IRAK-Un_bp-2_Smoe  REFLNEV------------------TVISAVQ-HR----NLV------------------
IRAK-Un_k-1_Smoe   REFMSEL------------------KVLTHVH-HT----NLV------------------
IRAK-Un_bd_Smoe    RDFYAEV------------------ASLARTN-HL----NLV------------------
IRAK-Un_h_Smoe     RHTVAEM------------------ETLGKIR-HV----NLA------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    EEFINEV------------------STISYLQ-HK----NLI------------------
IRAK-Un_ap-1_Smoe  RDFENEV------------------SAICLLQ-HK----NVV------------------
IRAK-Un_ap-2_Smoe  RDFENEV------------------STICLLQ-HK----NVV------------------


IRAK-Un_aw_Smoe    -AVIGCCYD-H-----------------GERYIAYEYIANGPLDLWLHDPV---------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    -KLFGFCSE-K-----------------EHKLIVCEFIENGNLSEALFSSPD--------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    -KLQGYGAH-G-----------------QHYYRVCG--ISGSLLR---SM----------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  -RIWGCCVD-TG-----------------EPLVVYEYIPNGTLYEWLHVG--R-------
IRAK-Un_da_Smoe    -KLLGFCAE-G-----------------DHRILVYEYVNNGNLDEWLHGKTS--------
IRAK-Un_dg_Smoe    -NLVGICDE-K-----------------QERMLLFQYAPNGTLFENLHTG----------
IRAK-Un_dj_Smoe    -QIIGICSS-SSAGGGGGGGGDCADGHAQRMLLVLRQMPNGDLASALRRGDEFK---SSD
IRAK-Un_dm_Smoe    -PLLGYCTE-GQ-----------------HEMLVYPYMSNGTLQDRLYGE--A-------
IRAK-Un_ag_Smoe    -QLLDHVW------------------LHPGVLLVLEFL-PGSLAEVIEERKE--------
IRAK-Un_dq_Smoe    -QLLDHVW------------------LHPGVLLVLEFL-PGSLAEVIEERKE--------
IRAK-Un_dh_Smoe    -KFIGFCAE-GP----------------RKRLLVYEFVANGSLEKWIFVDGGGDDDSS--
IRAK-Un_dp_Smoe    -QLLGCSTD-GQ-----------------SLLLVYEFVGNGTLADHLHTK--K-------
IRAK-Un_bk-2_Smoe  -PLLGHCLE-R----------------ENEKFLVYKYMQHGDLARALHRKIVPS------
IRAK-Un_bk-1_Smoe  -PLLGHCLE-R----------------ENEKFLVYKYMQHGDLARALHRKIVPS------
IRAK-Un_ck_Smoe    VQLIGYCTV--E-----------------SLFLVYEFVDNGTLAQHLHST----------
IRAK-Un_cn_Smoe    -NLVGFSSD-A-----------------QQKCLVFDYMHLGRLSRRLFDD----------
IRAK-Un_bg_Smoe    -RLLGFCQS-GK-----------------NQ-----------------------------
IRAK-Un_cj_Smoe    VQLIGYCTV--E-----------------SLFLVYEFVDNGTLAQHLHSA----------
IRAK-Un_v-2_Smoe   -QLLGCCLE-VY-----------------DPLLVYEFVPNGTLAEHLQRE--R-------
IRAK-Un_de_Smoe    -NLVGYCTD-RR-----------------ERMLVYEYMSNGSLEKLLYND--K-------
IRAK-Un_dk_Smoe    -SLKGFYCS-A-----------------QEKLLFYDYMPCGSLHDVLHGGGVA-------
IRAK-Un_bv_Smoe    -PLRGWHCA-RD---------------HRELVLVYDYMPQGSVESALFHKGD--------
IRAK-Un_ay-2_Smoe  -RLFGFCSE-K-----------------EHKLIVCELVENGNLSDALFELLTRV---S--
IRAK-Un_ay-1_Smoe  -KLFGFCSE-K-----------------EHKLIVCELVENGNLSDALFEIMKRV---S--
IRAK-Un_df_Smoe    -LLLGGNP---E-----------------KKCLVYEYLENGSLEDRLFCK----------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     -NLVGYCAQ--------------------EQLLAFEFMENGSLFDCLFKK--P-------
IRAK-Un_bb_Smoe    -KLRGYCLD-R-----------------DDRILVYEFLENKSLDQLLFESAT--------
IRAK-Un_v-1_Smoe   -QLLGCCLE-VY-----------------DPLLVYEFVPNGTLAEHLQRE--R-------
IRAK-Un_bx-1_Smoe  -GLIGFCAE-T-----------------KRKMLVYEFMANRSLQEVLFDE----------
LRR10a_d-2_Smoe    -PLLGYCIA-G-----------------NERLLVYKHMPCGNLYNRLHTAAAST---P--
IRAK-Un_cz_Smoe    -AVIGCCYD-H-----------------GERYIAYEYIANGPLDLWLHDPV---------
IRAK-Un_e_Smoe     -KLKGWCMD-TR-------------R-NAPPLLVYEYVTNGTLLEHLQCK--R-------
IRAK-Un_dn_Smoe    -MLHGYCVE-A-----------------NERLLVYEFLENGSLDSALFQSS---------
IRAK-Un_do_Smoe    -SLRGFCMR-KN-----------------ERFLVYDFMENGSLKERLHLHHRG-------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  -NLIGCCCE-G-----------------DERLLVAEYMPNDTLTKHLFHW----------
IRAK-Un_av-1_Smoe  -NLIGCCCE-G-----------------DERLLVAEYMPNDTLTKHLFHW----------
IRAK-Un_bx-2_Smoe  -GLIGFCAD-S-----------------KRKMLVYEFMANRSLQEILFDE----------
IRAK-Un_am-1_Smoe  -RIWGCCVD-TG-----------------EPLVVYEYIPNGTLYEWLHVG--R-------
IRAK-Un_bj-2_Smoe  -KLKGFCCVQG----------------GLQCYLVYDFVPNGSLFEHLHGPS---------
IRAK-Un_bj-1_Smoe  -KLKGFCCVQG----------------GLQCYLVYDFVPNGSLFEHLHGPS---------
RKF3_a-2_Smoe      -SVRGACVH-AN-------------GPDSQHILVYDYMPNGCLKTYLSS-----------
IRAK-Un_bo-2_Smoe  -SLLGFCQE-H-----------------DHQMLVYDYLPNGSVSSHLCDPNG--------
IRAK-Un_dc_Smoe    -LLLGGNP---E-----------------KKCLVYEYLENGSLEDRLFCK----------
IRAK-Un_k-2_Smoe   -QLIGYCTV--D-----------------SLFLVYEYVDNGTLSHHLRGS----------
IRAK-Un_bo-1_Smoe  -SLLGFCQE-H-----------------DHQMLVYDYLPNGSVSSHLCDPNG--------
IRAK-Un_cb_Smoe    -EYIDFFEI-EN--------------EKDKGFYIVQKVAKGKSLAKLVEEGW--------
IRAK-Un_cs_Smoe    -RLLGFCTS-P-----------------FLHALVMPLEKRGCLKGMVLD-----------
IRAK-Un_cu_Smoe    -PLLGHCLE-M----------------DELKFLVYKYMPNGDLGQALHKKVVPS------
IRAK-Un_t_Smoe     -PLLGHCLE-M----------------DELKFLVYKYMPNGDLGQALHKKVVPS------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  -KLHGCCIE-G-----------------SHRILIYEFLENNSLHQALLKPKE--------
IRAK-Un_bp-2_Smoe  -KLHGCCIE-G-----------------SHRILIYEFLENNSLHQALLKPKE--------
IRAK-Un_k-1_Smoe   -QLIGYCTV--D-----------------SLFLVYEYVDNGTLSHHLRGS----------
IRAK-Un_bd_Smoe    -KFIGFCAE-GP----------------RKRLLVYEFVPNGSLEKWIFGDDGGD-DSS--
IRAK-Un_h_Smoe     -WLYAYILK-P-----------------DAHLLLYQYMPRGSLQDVLARVRD--------
IRAK_Un_dd_Smoe    -----------------------------------EFVPNGTLAEHLQRE--R-------
IRAK-Un_bf_Smoe    -RLVGFCCE-G-----------------EHRLLVYEFLENNSLALAILSGPN--------
IRAK-Un_ap-1_Smoe  -KLFGFCSE-K-----------------EHKLIVCEFIENGNLSDALFRSPD--------
IRAK-Un_ap-2_Smoe  -KLFGFCSE-K-----------------EHKLTVCEFIENGNLSDALFRSPD--------


IRAK-Un_aw_Smoe    -------------RRGTLD-WRTRMQIAVTAAQGIAYLHDQV-KPHVIHRDIKASSILLD
IRAK-Un_co_Smoe    -------------------------------------------SPPIYHRDVKSSNILLD
IRAK-Un_ax_Smoe    -------------KGLELN-WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLA
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    -------------KQQALR-WERRWRIAADIARGLDYLHGGC-KDQVLHLDIKPQNILLD
IRAK-Un_ca_Smoe    ----------------------------REIARGICFLHEEC-STRVLHLAINPQNTLLA
IRAK-Un_am-2_Smoe  ---------------GFLD-WRSRLRIALQTAEGLAYLHSAA-YPPIYHRDVKSSNILLD
IRAK-Un_da_Smoe    -------------RFKTPS-WDSRMKIILGTAKGLAYMHEAI-EPKIVHRDIKASNILLD
IRAK-Un_dg_Smoe    --------------DENLS-WKQRMRIIVGAAYGLAYLHHLC-NPPVIHGDLRSRNILLT
IRAK-Un_dj_Smoe    GETSESSDSSSAGSAKPLD-WITRFKIAIGVAEALAFLHHDC-SPAVIHRDLKSSSVFLD
IRAK-Un_dm_Smoe    ------------ATRKPLD-WQTRLSIAIGAARGLNFLHTSG-PRPIIHRDVKSSNILLD
IRAK-Un_ag_Smoe    ---------------IPFQEFEAR-NWMEQILKAVAECH----SAGILHRDLKPSNLLIS
IRAK-Un_dq_Smoe    ---------------IPFQEFEAR-NWMEQILKAVAECH----SAGILHRDLKPSNLLIS
IRAK-Un_dh_Smoe    --------SQQQDGSGGLS-WDFKFRIAVGTAQGLCYLHEEC-AEKIIHLDLKPENVLVD
IRAK-Un_dp_Smoe    ---------------SRLP-WLTRLAIAIDIAQVLAYLHSY----SILHRDVKSTNVLLD
IRAK-Un_bk-2_Smoe  ---------PPKDILQSLD-WITRLKIAIGAAEGLSYLHHEC-SPALVHRDIKATSILLD
IRAK-Un_bk-1_Smoe  ---------PPKDILQSLD-WITRLKIAIGAAEGLSYLHHEC-SPALVHRDIKATSILLD
IRAK-Un_ck_Smoe    -------------TRPPLS-WSSRIQIAMDAARGLEYIHEHA-KPTYIHRDIKSTNILID
IRAK-Un_cn_Smoe    -------------TLPPIS-WGNRLRIALQISRAVEYLHTYA-EPHIVHLNISAENVLLD
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    -------------TRPPLS-WSSRIQIAMDAARGLEYIHEHT-KPTYIHRDIKSTNILID
IRAK-Un_v-2_Smoe   --------------GDGLD-WFTRVAIAAEAAQGIAYLHSRS--PPIYHRDVKSTNILLD
IRAK-Un_de_Smoe    --------------REALS-WSERVQIAKDVSRGIEYLHDGA-VPPVIHRDIKSANILLD
IRAK-Un_dk_Smoe    ----------SASPSTLLS-WMARLRIAVGTARGLLYLHEGC-SPRIIHRDVKSSNILLD
IRAK-Un_bv_Smoe    --------------ALLLL-WDARLRILSGLAAALIYLHEDW-EQQVIHRDVKCSNVMLD
IRAK-Un_ay-2_Smoe  --------SISVRNDLQLD-WTARYNICVGVAQGLAYLHGETSQVTIVHRDIKALNILLA
IRAK-Un_ay-1_Smoe  --------SISVWKDLQLD-WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLA
IRAK-Un_df_Smoe    ------------DDSPPIS-CLTRYQIAVEVGTALLFLHKAK-PQPIVLRDLKPSNILLD
IRAK-Un_bt_Smoe    --------------------------------RGLKYLHEIV-SPLIIHRDFKSSNILLA
IRAK-Un_r_Smoe     --------------EIRLD-WFLRIRIAAQAARGLEYLHIYA-SPQILHRDVKAANILLD
IRAK-Un_bb_Smoe    --------------GIFLD-WPTRFQIVLGVANGLAYLHEGS-QKQIIHRDIKASNILLD
IRAK-Un_v-1_Smoe   --------------GDGLD-WFTRVAIAAEAAQGIAYLHSRS--PPIYHRDVKSTNILLD
IRAK-Un_bx-1_Smoe  ------------KHSVVLQ-WERRAKIVADVARALAFLHGKC-EPPIVHGDVKPSNVLLG
LRR10a_d-2_Smoe    ------GDSSSGSTSGRLD-WAARLKVAVGTARGLAWLHHSC-NPRLVHKGITSASILLD
IRAK-Un_cz_Smoe    -------------RRGTLD-WRTRMQIAVTAAQGIAYLHDQV-KPHVIHRDIKASSILLD
IRAK-Un_e_Smoe     -------------GVVPLG-WEQRLQIVIETAEALAYLHSVA-APPIYHRDVKSSNILLD
IRAK-Un_dn_Smoe    ---------------SALN-WQSRFQITIGIARGLAYLHEES-HFQIIHRDIKASNVLLD
IRAK-Un_do_Smoe    ------------RSNGTLS-WQRRLQIAIEVATGMEYVHCYC-EPPLCHGNLKSSNILLD
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  -------------EKQPMQ-WSMRLRVALYIAQALEHCSN---NNRRLYHDLNAYRVLFD
IRAK-Un_av-1_Smoe  -------------EKQPMQ-WSMRLRVALYIAQALEHCSN---NNRRLYHDLNAYRVLFD
IRAK-Un_bx-2_Smoe  ------------KHSVVLQ-WERRAKIVADVARALAFLHGKC-EPPIVHGDVKPSNVLLG
IRAK-Un_am-1_Smoe  ---------------GFLD-WRSRLRIALQTAEGLAYLHSAA-YPPIYHRDVKSSNILLD
IRAK-Un_bj-2_Smoe  --------------VSPLD-WGTRVQIAHGVAKGLDYLHRNG-EQVI----VWASNVLLD
IRAK-Un_bj-1_Smoe  --------------VSPLD-WGTRVQIAHGVAKGLDYLHRNG-EQVI----VWASNVLLD
RKF3_a-2_Smoe      ---------------GTLS-WQQRRKIAIGIAVGINYLHNEV-EPSIIHRDIKPSNILLD
IRAK-Un_bo-2_Smoe  ------------NPTGELD-FKQRVAIALGAARGLEYLHSGN--PPRVHQDFKTSNVLLD
IRAK-Un_dc_Smoe    ------------DDSPPIS-CLTRYQIAVEVGTALLFLHKAK-PQPIVLRDLKPSNILLD
IRAK-Un_k-2_Smoe   -------------APSRLT-WNQRIQIALDAARGLEYIHEHT-KPTYIHRDVKSPNILID
IRAK-Un_bo-1_Smoe  ------------NPTGELD-FKQRVAIALGAARGLEYLHSGN--PPRVHQDFKTSNVLLD
IRAK-Un_cb_Smoe    ----------------RVS-EQEVKDIAIEILDVLKYLGS-L-RPPVIHRDIKPDNIILD
IRAK-Un_cs_Smoe    ---------------GSLG-WKQRVKIIKGLALALDHLH---------------------
IRAK-Un_cu_Smoe    ---------PPADILQSLD-WITRLKIAIGVAEGLSYLHHEC-VPPLVHRDVQASSILLD
IRAK-Un_t_Smoe     ---------PPADILQSLD-WITRLKIAIGVAEGLSYLHHEC-VPPLVHRDVQASSILLD
IRAK-Un_dd_Smoe    ----------------------------------------------IIRRDLRPHNILLT
IRAK-Un_bp-1_Smoe  -------------RVIHFD-WPTRFNICVGIARGIAYLHEES-LPRIVHRDIKASNVLLD
IRAK-Un_bp-2_Smoe  -------------RVIHFD-WPTRFNICVGIARGIAYLHEES-LPRIVHRDIKASNVLLD
IRAK-Un_k-1_Smoe   -------------APSRLT-WNQRIQIALDAARGLEYIHEHT-KPTYIHRDVKSPNILID
IRAK-Un_bd_Smoe    --------SQQQDGSGGLS-WDCKFRIAVGTAQGLCYLHEEC-ADRIIHLDLKPENVLVD
IRAK-Un_h_Smoe     -------------GAMELE-WSARQRIATGMVRGLKYLHYDC-SPKILHRDLKTSNILLD
IRAK_Un_dd_Smoe    --------------GDGLD-WFTRVAIAADAAQGIAYLHSRS--PPIYHRDVKSTNILLD
IRAK-Un_bf_Smoe    --------------KLYIP-WAKRYEICLGVARGIAYLHEES-RTRIVHRDIKASNILLD
IRAK-Un_ap-1_Smoe  -------------KGLELN-WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALNILLA
IRAK-Un_ap-2_Smoe  -------------KGLELN-WTARYNICVGVAQGLAYLHGETSQATIVHRDIKALSILLA


IRAK-Un_aw_Smoe    DKF--------------------HGRVMGVGLASVVPWEA---AYER-------------
IRAK-Un_co_Smoe    EKL--------------------TANVADFGISKVVPIDST-------------------
IRAK-Un_ax_Smoe    SNL--------------------EAKISDFGLARLIQEDR---SYIS-------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ASF--------------------GAKICDFGLERVDHEK----NSVS-------------
IRAK-Un_ca_Smoe    ENF--------------------GVKIADVGLS---------------------------
IRAK-Un_am-2_Smoe  NSL--------------------VARVCDFGLSRLAEPDL---SHVS-------------
IRAK-Un_da_Smoe    SHW--------------------NAKVSDFGLAKFLGCEK---THVM-------------
IRAK-Un_dg_Smoe    EDF--------------------AAKVWAMVVPIAGSSE-------L-------------
IRAK-Un_dj_Smoe    EGY--------------------EVRLGSF------------------------------
IRAK-Un_dm_Smoe    DSM--------------------NARVADFGFSRFAPQE--DDSLVS-------------
IRAK-Un_ag_Smoe    SDG--------------------VLKVADFGTALVLPVEN---VEEALKS----------
IRAK-Un_dq_Smoe    SDG--------------------VLKVADFGTALVLPVEN---VEEAVKDSSSGKKKLKG
IRAK-Un_dh_Smoe    IGF--------------------VPKIADFGLSKLMNREV---TYL--------------
IRAK-Un_dp_Smoe    EGF--------------------HAKLGDFGLSKAAAAAAAVEGHVS-------------
IRAK-Un_bk-2_Smoe  DKF--------------------EVRL---------------------------------
IRAK-Un_bk-1_Smoe  DKF--------------------EVRL---------------------------------
IRAK-Un_ck_Smoe    KNF--------------------HAKVADFGLSKLTETGM---TSIS-------------
IRAK-Un_cn_Smoe    GSW--------------------NAKLSGFGR----------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    KNL--------------------HAKVADFGLSKLTETGM---TSIS-------------
IRAK-Un_v-2_Smoe   GEF--------------------NTKVGDFGLSRTALTEA---SHVS-------------
IRAK-Un_de_Smoe    NSM--------------------TARVADFGLSKEVS-P--V--VPT-------------
IRAK-Un_dk_Smoe    SDM--------------------EPHIADFGLARLVENNA---THLT-------------
IRAK-Un_bv_Smoe    EEF--------------------RARLGDFGLARTASHDV---SSRT-------------
IRAK-Un_ay-2_Smoe  SDL--------------------KPKISDFGLARLIQQSR---SYIS-------------
IRAK-Un_ay-1_Smoe  SDL--------------------KPKISDFGLARLIQQSR---SYTS-------------
IRAK-Un_df_Smoe    KNY--------------------NSKISDVGLARFMPGDE---TSVR-------------
IRAK-Un_bt_Smoe    DKF--------------------NTKVSDFGLAKLGLDKA--------------------
IRAK-Un_r_Smoe     KDW--------------------NAHLSDFGFSLSPS-G--NTTQL--------------
IRAK-Un_bb_Smoe    HKL--------------------HPKISDFEISKL-------------------------
IRAK-Un_v-1_Smoe   GEF--------------------NTKVGDFGLSRTALTEA---SHVS-------------
IRAK-Un_bx-1_Smoe  ADF--------------------GAKLADFGLARVKTQES---AAVD-------------
LRR10a_d-2_Smoe    EDL--------------------EPRITDFGLARLIVTGR---GRPG-------------
IRAK-Un_cz_Smoe    DKF--------------------HGRVMGVGLASVVPWEA---AYER-------------
IRAK-Un_e_Smoe     DSL--------------------SAKVADFGISKLVGTGDAATTHVS-------------
IRAK-Un_dn_Smoe    AKL--------------------QPKISDFGLSKLFDLDG---KHVV-------------
IRAK-Un_do_Smoe    ENF--------------------VAKV---------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  QVLFNPFRSLLVYALTAAVLQDGDPRLSCFGLMKNSRDG---------------------
IRAK-Un_av-1_Smoe  QVLFNPFRSLLVYALTAAVLQDGDPRLSCFGLMKNSRDG---------------------
IRAK-Un_bx-2_Smoe  ADF--------------------GAKLADFGLARVKTQES---AAVD-------------
IRAK-Un_am-1_Smoe  NSL--------------------VARVCDFGLSRLAEPDL---SHVS-------------
IRAK-Un_bj-2_Smoe  ESY--------------------NALVSSWGHNKVLADEL---VYAN-------------
IRAK-Un_bj-1_Smoe  ESY--------------------NALVSSWGHNKVLADEL---VYAN-------------
RKF3_a-2_Smoe      EDL--------------------NARVADFGLAKISPEGM---SHLT-------------
IRAK-Un_bo-2_Smoe  ENL--------------------VAKVTDVGLSKLLVTSH---NAMP-------------
IRAK-Un_dc_Smoe    KNY--------------------NSKISDVGLARFM------------------------
IRAK-Un_k-2_Smoe   KRL--------------------RAKVADFGLTKLTESGA---GSVS-------------
IRAK-Un_bo-1_Smoe  ENL--------------------VAKVTDVGLSKLLVTSH---NAMP-------------
IRAK-Un_cb_Smoe    EATG-------------------KVKVVDFGAVQDTTSSA---TF---------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    DKF--------------------EVRL---------------------------------
IRAK-Un_t_Smoe     DKF--------------------EVRL---------------------------------
IRAK-Un_dd_Smoe    HDY--------------------APMVGDFGLARWHT-----------------------
IRAK-Un_bp-1_Smoe  KTL--------------------NPKIADFGLAKLFKDHQ---THVS-------------
IRAK-Un_bp-2_Smoe  KTL--------------------NPKIADFGLAKLFKDHQ---THVS-------------
IRAK-Un_k-1_Smoe   KRL--------------------RAKVADFGLTKLTESGA---GSVS-------------
IRAK-Un_bd_Smoe    IGF--------------------VPKIADFGLSKLMNREV---TYL--------------
IRAK-Un_h_Smoe     EEL--------------------EAHLGDFGLAKALPDGM---THVT-------------
IRAK_Un_dd_Smoe    D-----------------------------------------------------------
IRAK-Un_bf_Smoe    KEF--------------------NARVSDFGLARLLKDGD---THLS-------------
IRAK-Un_ap-1_Smoe  SNL--------------------EAKISDFGLARLIQEDR---SYIS-------------
IRAK-Un_ap-2_Smoe  SNL--------------------EAKISDFGLARLIQEDR---SYIN-------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    -------------------------------AATSSEQQPETMVPAQIRGSKSYDRLEIE
IRAK-Un_dq_Smoe    GAEFDRFGSGKKLDSEEIEAWLQGGSFKLKSAATSSEQQPETMVPAQIRGSKSYDRLEIE
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    DSGT--------------------------------------------------------
IRAK-Un_dq_Smoe    DSGT--------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ---ERERNDDFGKLSRGGAATPSSIGGGQDDDEEWSKLSQSAYGTEADTWSKISPSEIDC
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ---ERERNDDFGKVSRGGAATPSSIGGGQDDDEEWSKLSQSAYGTEADTWSKISPSEIDC
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  RSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGNGKNSNNGSRDWWWKQESSGQQ
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  RSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGNGKNTNNGSRDWWWKQESSGQQ
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  GGGGGEFSIREYIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKK
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  GGGGGEFSIREYIVDWVSCENRRGRSRTREWPWNAASSGTAGAAAAGTSSEGKNNVKKKK
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  KQARSGSLEWWAECDDDDELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGELTSNETNNN
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  KQARSGSLEWWAECDDDDELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGELTSNETN-N
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    -------------------------------------------EVSPR------------
IRAK-Un_dq_Smoe    -------------------------------------------EVSPRVSDAEEEEDVLS
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  NRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSR----------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  NRKGGRLFETWSRESLSGELTRRRRRERSRSHSRDWWSGDLVSR----------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    -----------------------------------------------------------T
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    -----------------------------------------------------------T
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    -----------------------------------------------------------T
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ----------------------------------------------------------T-
IRAK-Un_da_Smoe    -----------------------------------------------------------T
IRAK-Un_dg_Smoe    -----------------------------------------------------------A
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ----------------------------------------------------------V-
IRAK-Un_ag_Smoe    ----VSDAEEEEDGARSRNDRYSDGEWEKTSNKDSDWYKSSKMWWCSSQVGNDDFRGEMT
IRAK-Un_dq_Smoe    FSLSQ----------------------------------SSKMWWCSSQVGNDDFRGEMT
IRAK-Un_dh_Smoe    ---------------------------------------------------------QMT
IRAK-Un_dp_Smoe    ----------------------------------------------------------I-
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    -------------------------------------------------------LTQPT
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    -------------------------------------------------------LTQPT
IRAK-Un_v-2_Smoe   ----------------------------------------------------------T-
IRAK-Un_de_Smoe    ----------------------------------------------------------S-
IRAK-Un_dk_Smoe    -----------------------------------------------------------T
IRAK-Un_bv_Smoe    -----------------------------------------------------------T
IRAK-Un_ay-2_Smoe  -----------------------------------------------------------T
IRAK-Un_ay-1_Smoe  -----------------------------------------------------------T
IRAK-Un_df_Smoe    ----------------------------------------------------------ST
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ----------------------------------------------------------A-
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ----------------------------------------------------------T-
IRAK-Un_bx-1_Smoe  -------------------------------------------------------VSSTP
LRR10a_d-2_Smoe    -----------------------------------------------------------G
IRAK-Un_cz_Smoe    -----------------------------------------------------------T
IRAK-Un_e_Smoe     ----------------------------------------------------------TL
IRAK-Un_dn_Smoe    -----------------------------------------------------------S
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  -----------------------------------------------------------K
IRAK-Un_av-1_Smoe  -----------------------------------------------------------K
IRAK-Un_bx-2_Smoe  -------------------------------------------------------VSSTP
IRAK-Un_am-1_Smoe  ----------------------------------------------------------T-
IRAK-Un_bj-2_Smoe  -----------------------------------------------------------I
IRAK-Un_bj-1_Smoe  -----------------------------------------------------------I
RKF3_a-2_Smoe      -----------------------------------------------------------T
IRAK-Un_bo-2_Smoe  -----------------------------------------------------------S
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   -------------------------------------------------------LTQPT
IRAK-Un_bo-1_Smoe  -----------------------------------------------------------S
IRAK-Un_cb_Smoe    ---------------------------------------------------------IGS
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  -----------------------------------------------------------T
IRAK-Un_bp-2_Smoe  -----------------------------------------------------------T
IRAK-Un_k-1_Smoe   -------------------------------------------------------LTQPT
IRAK-Un_bd_Smoe    ---------------------------------------------------------QMT
IRAK-Un_h_Smoe     -----------------------------------------------------------T
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    -----------------------------------------------------------T
IRAK-Un_ap-1_Smoe  -----------------------------------------------------------T
IRAK-Un_ap-2_Smoe  -----------------------------------------------------------T


IRAK-Un_aw_Smoe    V----VAGTH-GYLAPEF-V-------------YRNE---LTTKSDVYSFGVLMLELISG
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    R----AAGTV-GYLALEY-A-------------LSGQ---FTEKADVYSFGILVLEILSG
IRAK-Un_br-2_Smoe  ---------A-AYAAPEL-L-------------QRGTQSLPSPKSNVWSFGVVLLEILTG
IRAK-Un_bw_Smoe    V----MRGTP-GYMAP--------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  C----AQGTL-GYLDPEY-Y-------------RKYQ---LTDKSDVYSFGVVLLELV--
IRAK-Un_da_Smoe    R----VMGTF-GYVAPEY-A-------------NTGL---LNERSDVYSFGVLLMEVVTG
IRAK-Un_dg_Smoe    L----VRKTG-GYVDPEI-V-------------HRGV---YSRAGDVFSFGVLLLEVLSG
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    E----VRGTT-GYLDPEY-Y-------------MTQV---LTTKSDVFSFGVVLLEIVCG
IRAK-Un_ag_Smoe    D----CVGTR-WYKAPEL-L-------------YGST--SYNFAVDLWAVGCILGELIQG
IRAK-Un_dq_Smoe    D----CVGTR-WYKAPEL-L-------------YGST--SYNFAVDLWAVGCILGELIQG
IRAK-Un_dh_Smoe    S----MRGTP-GYLAPEY-L-------------QVGT---ITEKSDVFSFGVLLLEIITG
IRAK-Un_dp_Smoe    G----AQGTA-GYLDPEY-H-------------QCYA---LTDKSDVYSFGVLLMELITA
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    R----LVGTF-GYMSPEY-A-------------RYGD---VSPFLDVYSFGVVLFEI---
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    R----LVGTF-GYMSPEY-A-------------RYGD---VSPFLDVYSFGVVLFEI---
IRAK-Un_v-2_Smoe   A----PQGTP-GYVDPDY-H-------------QSFQ---LSDKSDVYSFGVVLVEMI--
IRAK-Un_de_Smoe    G----IKGTF-GYTDPEY-I-------------FTKV---FNEKSDVYSFGVLLFELMSG
IRAK-Un_dk_Smoe    G----IAGTL-GYIAPEV-V-------------STCR---LSEKTDVYSFGIVLLELLTG
IRAK-Un_bv_Smoe    T----LAGTL-GYIAPEV-G-------------VTYK---FTPASDVYSYGVVTLEVVTG
IRAK-Un_ay-2_Smoe  R----AAGTA-GYLAPEY-A-------------LYGQ---LTVKADVYSFGILVLEIISG
IRAK-Un_ay-1_Smoe  R----AAGTA-GYLAPEY-A-------------LSGQ---LTEKADVYSFGILVLEIISG
IRAK-Un_df_Smoe    S----PVGTF-AYIDPEY-Q-------------REGS---FNAKSDVFAFGIILLQLL--
IRAK-Un_bt_Smoe    -----GLGTQ-GYVAP--------------------------------------------
IRAK-Un_r_Smoe     T----MVGTP-GYMDPEY-F-------------QTAK---FTTKSDVYSFGVVLLELLTG
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   A----PQGTP-GYVDPDY-H-------------QSFQ---LSDKSDVYSFGVVLVEMI--
IRAK-Un_bx-1_Smoe  S----MRGTV-CYVAPEY-G-------------GGGV---LTEKSDVYSFGVLLLVVVSG
LRR10a_d-2_Smoe    AGGKSNSDEDGFYVPPEDYSTTYSLSRATSMSAASTT---ATPKGDVYAFGVVLLELVTG
IRAK-Un_cz_Smoe    V----VAGTH-GYLAPEF-V-------------YRNE---LTTKSDVYSFGVLMLELISG
IRAK-Un_e_Smoe     R----IQGTP-GYCDPEL-M-------------TTFR---LTDKSDVYSFGVVLLELVTG
IRAK-Un_dn_Smoe    K----VAGTF-GYMAPEY-A-------------VHRR---LSPKADVFSFGVPVLVILSG
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ---------A-AYAAPEL-L-------------QRGAQSLPSPKSNVWSFGVVLLEILTG
IRAK-Un_av-2_Smoe  S----YSTNL-AYTPPEY-L-------------RTGR---VTPESVIYSYGTVLLDLLSG
IRAK-Un_av-1_Smoe  S----YSTNL-AYTPPEY-L-------------RTGR---VTPESVIYSYGTVLLDLLSG
IRAK-Un_bx-2_Smoe  S----MRGTV-CYVAPEY-G-------------GGGV---LTEKSDVYSFGVLLLVVVSG
IRAK-Un_am-1_Smoe  C----AQGTL-GYLDPEY-Y-------------RKYQ---LTDKSDVYSFGVVLLELV--
IRAK-Un_bj-2_Smoe  K----TSAML-GYLAPEY-G-------------VIGH---LHEKSDVYAFGILLLELLTG
IRAK-Un_bj-1_Smoe  K----TSAML-GYLAPEY-G-------------VIGH---LHEKSDVYAFGILLLELLTG
RKF3_a-2_Smoe      R----VAGTP-IYMAVEY-A-------------LYGQ---CSDKVDVYSFGVLLLELMSG
IRAK-Un_bo-2_Smoe  A-----NGSSSHFADPAAVY-------------NTYR---VDPKSDVYSYGVFLLELISG
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   R----LVGTF-GYMPPEY-A-------------RFGD---VSPKIDVYSFGVVLYEI---
IRAK-Un_bo-1_Smoe  A-----NGSSSHFADPAAVY-------------NTYR---VDPKSDVYSYGVFLLELISG
IRAK-Un_cb_Smoe    T----VVGTY-GYMAPEQ-F-------------Q-NR---ATLQTDLYGLGGTLLFMLSG
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  R----VAGTI-GYLSPEY-A-------------MRGQ---LTEKADVYSFGVLVLEIVSG
IRAK-Un_bp-2_Smoe  R----VAGTI-GYLSPEY-A-------------MRGQ---LTEKADVYSFGVLVLEVVSG
IRAK-Un_k-1_Smoe   R----LVGTF-GYMPPEY-A-------------RFGD---VSPKIDVYSFGVVLYEI---
IRAK-Un_bd_Smoe    S----MRGTP-GYLAPEY-L-------------QVGT---ITEKSDVFSFGVLLLEIITG
IRAK-Un_h_Smoe     Q----VAGTI-GYIAPEY-H-------------QTCK---FTVSSDVYSMGIVLGVLISG
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    R----VAGTF-GYLAPEY-A-------------LRGK---LTEKADVYSFGILLLEILSG
IRAK-Un_ap-1_Smoe  R----AAGTV-GYLAPEY-A-------------LSGQ---LTEKADVYSFGILVLEILSG
IRAK-Un_ap-2_Smoe  R----ATGTV-GYLAPEY-A-------------LSGQ---LTEKADVYSFEILVLEILSG


IRAK-Un_aw_Smoe    R---------------------------------------K-------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  RQNRDEMFAVEEQDLVGWTAPYLANDKKLFLVVDPELKGMF-------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    R---------------------------------------D-------------------
IRAK-Un_dg_Smoe    KQA---------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    R---------------------------------------E-------------------
IRAK-Un_ag_Smoe    EP---------------------------------------LFPGAS-DIDQLS------
IRAK-Un_dq_Smoe    EP---------------------------------------LFPGAS-DIDQLS------
IRAK-Un_dh_Smoe    C---------------------------------------RNKYMSS-DYLRSFSL----
IRAK-Un_dp_Smoe    K-----------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    R---------------------------------------HPQHGLM-DYVQMASL----
IRAK-Un_dk_Smoe    R---------------------------------------K-------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  R---------------------------------------RP------------------
LRR10a_d-2_Smoe    R---------------------------------------R-------------------
IRAK-Un_cz_Smoe    R---------------------------------------K-------------------
IRAK-Un_e_Smoe     Q---------------------------------------K-------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  RQNRDEMFAVEEQDLVGWTAPYLANDKKLFLVVDPELKGMF-------------------
IRAK-Un_av-2_Smoe  KHIPPSHA------------LDLIRGKNILMLMDSYLEGQF-------------------
IRAK-Un_av-1_Smoe  KHIPPSHA------------LDLIRGKNILMLMDSYLEGQF-------------------
IRAK-Un_bx-2_Smoe  R---------------------------------------RP------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  R---------------------------------------KPM-----------------
IRAK-Un_bj-1_Smoe  R---------------------------------------KPM-----------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    RS---------------------------------------PATFPQ-KRLR--------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     R---------------------------------------EPTDEFFKDF----PGGIVP
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------RVVRVLGVPNETIWPG-------------ISSLPDYDKICFNDDRPPVTLARIL
IRAK-Un_dq_Smoe    ------RVVRVLGVPNETIWPG-------------ISSLPDYDKICFNDDRPPVTLARIL
IRAK-Un_dh_Smoe    --GDFSRQKSFTKSIS-----KTRKNLCDGGSSGGVA--------------------DKY
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    --GVDEENSDWIELLD-----SRL------------N--------------------GNC
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    -----------------------------------------------------VDFQN-F
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     WMCYLVQSGQELRGID-----PTL------------LKPAARGGGEGGGDDTLGQTPGFA
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    --------------------------------------P
IRAK-Un_co_Smoe    --------------------------------------R
IRAK-Un_ax_Smoe    --------------------------------------R
IRAK-Un_br-2_Smoe  PAR---SVSLFAKLAAQCLQRDPAARP-SMDQ--VVQSL
IRAK-Un_bw_Smoe    --------------------------------------E
IRAK-Un_ca_Smoe    --------------------------------------R
IRAK-Un_am-2_Smoe  --------------------------------------T
IRAK-Un_da_Smoe    --------------------------------------P
IRAK-Un_dg_Smoe    ----------------------------------FSEET
IRAK-Un_dj_Smoe    --------------------------------------G
IRAK-Un_dm_Smoe    --------------------------------------P
IRAK-Un_ag_Smoe    -PR---ASGEALRLIEKLLVYDPASRL-SASQALSHEFF
IRAK-Un_dq_Smoe    -PR---ASGEALRLIEKLLVYDPASRL-SASQALSHEFF
IRAK-Un_dh_Smoe    Q---AAGMERLKAVAYLCVQDDPDMRP-SMST---ALKM
IRAK-Un_dp_Smoe    --------------------------------------P
IRAK-Un_bk-2_Smoe  --------------------------------------G
IRAK-Un_bk-1_Smoe  --------------------------------------G
IRAK-Un_ck_Smoe    --------------------------------------I
IRAK-Un_cn_Smoe    --------------------------------------A
IRAK-Un_bg_Smoe    --------------------------------------V
IRAK-Un_cj_Smoe    --------------------------------------I
IRAK-Un_v-2_Smoe   --------------------------------------T
IRAK-Un_de_Smoe    NLQ---ELAKLASIAHRCVRKDPETRP-PMRE--IVQWL
IRAK-Un_dk_Smoe    --------------------------------------P
IRAK-Un_bv_Smoe    --------------------------------------R
IRAK-Un_ay-2_Smoe  --------------------------------------R
IRAK-Un_ay-1_Smoe  --------------------------------------R
IRAK-Un_df_Smoe    --------------------------------------T
IRAK-Un_bt_Smoe    --------------------------------------E
IRAK-Un_r_Smoe     --------------------------------------R
IRAK-Un_bb_Smoe    --------------------------------------F
IRAK-Un_v-1_Smoe   --------------------------------------T
IRAK-Un_bx-1_Smoe  -------------------------------------LQ
LRR10a_d-2_Smoe    --------------------------------------P
IRAK-Un_cz_Smoe    --------------------------------------P
IRAK-Un_e_Smoe     --------------------------------------P
IRAK-Un_dn_Smoe    --------------------------------------R
IRAK-Un_do_Smoe    --------------------------------------S
IRAK-Un_br-1_Smoe  PAR---SVSLFAKLAAQCLQRDPAARP-SMDQ--VVQSL
IRAK-Un_av-2_Smoe  SND---DGTELVRLASRCLQYEPRERP-TAKM--LVQAL
IRAK-Un_av-1_Smoe  SND---DGTELVRLASRCLQYEPRERP-TAKM--LVQAL
IRAK-Un_bx-2_Smoe  -------------------------------------LQ
IRAK-Un_am-1_Smoe  --------------------------------------T
IRAK-Un_bj-2_Smoe  ------------------------------------YAD
IRAK-Un_bj-1_Smoe  ------------------------------------YAD
RKF3_a-2_Smoe      --------------------------------------R
IRAK-Un_bo-2_Smoe  --------------------------------------R
IRAK-Un_dc_Smoe    --------------------------------------P
IRAK-Un_k-2_Smoe   --------------------------------------I
IRAK-Un_bo-1_Smoe  --------------------------------------R
IRAK-Un_cb_Smoe    -VS---ASPSMTRVVEKLLEPAPEDRYQSADE--VIRAL
IRAK-Un_cs_Smoe    --------------------------------------D
IRAK-Un_cu_Smoe    --------------------------------------G
IRAK-Un_t_Smoe     --------------------------------------G
IRAK-Un_dd_Smoe    --------------------------------------S
IRAK-Un_bp-1_Smoe  --------------------------------------R
IRAK-Un_bp-2_Smoe  --------------------------------------R
IRAK-Un_k-1_Smoe   --------------------------------------I
IRAK-Un_bd_Smoe    --------------------------------------C
IRAK-Un_h_Smoe     NLDEITEMKRAMRIACLCTKLNPQDRP-STKD---VLVM
IRAK_Un_dd_Smoe    --------------------------------------E
IRAK-Un_bf_Smoe    --------------------------------------R
IRAK-Un_ap-1_Smoe  --------------------------------------R
IRAK-Un_ap-2_Smoe  --------------------------------------R