IRAK-Un_aw_Smoe    CPDG--------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  K-----------------------------------------------------------
IRAK-Un_bw_Smoe    LDAEDPRL--GCKL---NR-----------P-PL-------DH---------Q------L
IRAK-Un_ca_Smoe    MAIALARSL--S------------------------------------------------
IRAK-Un_am-2_Smoe  MALPFQCRRIGI-LQTL--APAAIVSKMLAFSLLL---LYFSQ---------I------C
IRAK-Un_da_Smoe    MASESTR----S-A---P------------------------------------------
IRAK-Un_dg_Smoe    MATWIFGI------------------------VG--------------------------
IRAK-Un_dj_Smoe    MDVRLAVW----------------------------------------------------
IRAK-Un_dm_Smoe    MELKVNK-----------------------------------------------------
IRAK-Un_ag_Smoe    MESEEEEEG--A------------------------------------------------
IRAK-Un_dq_Smoe    MESEEEEEG--A------------------------------------------------
IRAK-Un_dh_Smoe    MGLRNG----SN-L---HL---------FPL-LVLV-AIGAAR-----------------
IRAK-Un_dp_Smoe    MIIIYA------------------------------------------------------
IRAK-Un_bk-2_Smoe  MIMGAPPGG-KL-L---LA-----------L-SLLL-SIEPLH---------S------S
IRAK-Un_bk-1_Smoe  MIMGAPPGG-KL-L---LA-----------L-SLLL-SIEPLH---------S------S
IRAK-Un_ck_Smoe    MKCGRRT----R-Q---E------------------------------------------
IRAK-Un_cn_Smoe    MKGSNCSW--HF------------------------------H---------A------L
IRAK-Un_bg_Smoe    MKTHSITT---------EI-------------T-VG-SAI-MD-----------------
IRAK-Un_cj_Smoe    MLGTTSS----S-L---SP---------SI--LNPS-YCAPRQASHLLGFVPGIVCADLH
IRAK-Un_v-2_Smoe   MRDAKQ------------------------------------------------------
IRAK-Un_de_Smoe    MSSPPPS----I-S----------------------------------------------
IRAK-Un_dk_Smoe    MTSDLARF-I-A-I---LT---------L---GFVICAAGSEI---------V------D
IRAK-Un_bv_Smoe    MVESRKI----D-S---R------------------FT----------------------
IRAK-Un_ay-2_Smoe  MVFLTEK-----------------------------------------------------
IRAK-Un_ay-1_Smoe  MVFLTEK-----------------------------------------------------
IRAK-Un_df_Smoe    MVSTSPLKS--H-L---------------------S-MRGSDS---------K------D
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     RGWR--------------------------------------------------------
IRAK-Un_bb_Smoe    F-----------------------------------------------------------
IRAK-Un_v-1_Smoe   MAYSGSGRRRR--RRRIHFHPLVL--PFLWISLAIP-IQGSPR---------A------E
IRAK-Un_bx-1_Smoe  MARRIIA----A-V---HQ---------H---R---NA----------------------
LRR10a_d-2_Smoe    MAMRLAVL---------AL-------------LAMA-VAAQED-----------------
IRAK-Un_cz_Smoe    FFFLLF-F---------FL-------------LGAC-FMNVAR-----------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    MPLDMLG----V------------------------------------------------
IRAK-Un_do_Smoe    MDGRIVP------LETL--DPSSFAVSW-WKRYEV---RS-FQ---------V------S
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  DA----------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  MARRIIA----A-V---HQ---------H---R---NA----------------------
IRAK-Un_am-1_Smoe  MALPFQCRRIGI-LQTL--APAAI--KMLAFSLLL---LYFSQ---------I------C
IRAK-Un_bj-2_Smoe  MGSRPHLL--AL-L---SA-----------L-AALA-ALGGAR---------A------A
IRAK-Un_bj-1_Smoe  MGSRPHLL--AL-L---SA-----------L-AALA-ALGGAW---------A------A
RKF3_a-2_Smoe      MRIVTLV-----------A-----------I-A-LL-AAGA-------------------
IRAK-Un_bo-2_Smoe  MPQNQDG-----------------------------------------------------
IRAK-Un_dc_Smoe    MENRIELQC---------------------------------------------------
IRAK-Un_k-2_Smoe   MGNLWIV----A-I---SI---------A---LGMV-ILAPGR-----------------
IRAK-Un_bo-1_Smoe  GAI---------------------------------------------------------
IRAK-Un_cb_Smoe    MLLENLHFS--L------------------------------------------------
IRAK-Un_cs_Smoe    MGARLSRLE---------------------------------------------------
IRAK-Un_cu_Smoe    MSLGLAWA-----I---LA-----------L-LGVV-TILPAE---------S------Q
IRAK-Un_t_Smoe     MSLGLAWA-----I---LA-----------L-LGVV-TILPAE---------S------Q
IRAK-Un_dd_Smoe    MVCKTGNR-F--------------------------------------------------
IRAK-Un_bp-1_Smoe  MEELPLS----I-L---FL-------------FVLL-LHGAAQ---------G------Q
IRAK-Un_bp-2_Smoe  MEELPLS----I-L---FL-------------FVLL-LHGAAQ---------G------Q
IRAK-Un_k-1_Smoe   MGNLWIV----A-I---SI---------A---LGMV-ILAPGR-----------------
IRAK-Un_bd_Smoe    MGLSDRGRNGSN-L---HL---------FPL-LVLV-AIGAAR-----------------
IRAK-Un_h_Smoe     MAGFLAL----I-L---SS---------L---WVL-LLLGGCH---------G------E
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  PSLSSKS-----------------------------------------------------
IRAK-Un_ap-2_Smoe  PSLSSKS-----------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    -------------------RNN--------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  D---GASPY-QC-PS-----------CGNAT-----------VPFPLSTDP-------S-
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    -------AL-QC-YP-----------VNQTTSYNSD-DLGDYWQYPLDTDG-------L-
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  S----S-GGGDI-KISS--RGD--------------------------------------
IRAK-Un_bk-1_Smoe  S----S-GGGDI-KISS--RGD--------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    -------------------QNS--------------------------------------
IRAK-Un_bg_Smoe    ---------LD-----A-------------------------------------------
IRAK-Un_cj_Smoe    E----E-------ARLD--RSDGRLRV------------GNPPARPSNSESLRRVLWGD-
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    E---NADPI-KS-FEVE---EE--------------------------------------
IRAK-Un_bv_Smoe    ----------------S--S----------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    EIAEGSYQP-QT-P-------------ELTV-----------VPPAFRTEE-------EF
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   E--AQASP--DCVYR-----------CGNTT-----------VPYPFFIAP-------S-
IRAK-Un_bx-1_Smoe  ----------------S--S----------------------------------------
LRR10a_d-2_Smoe    ---------VEC-L-REIK-----------------------------------------
IRAK-Un_cz_Smoe    ---------ATP-AVTTCP----------------D------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    S--ERATP--PCV-------------CFLAA-----------CPFNLTA-L-------D-
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ----------------S--S----------------------------------------
IRAK-Un_am-1_Smoe  D---GASPY-QC-PS-----------CGNAT-----------VPFPLSTDP-------S-
IRAK-Un_bj-2_Smoe  -------------------RSD--------------------------------------
IRAK-Un_bj-1_Smoe  -------------------RSD--------------------------------------
RKF3_a-2_Smoe      A----R-GDGDP-ASCSVDYSY--------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    --------------TLL--ASE--------------------------------------
IRAK-Un_t_Smoe     --------------TLL--ASE--------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  Q----Q-------RTLD--PTE--------------------------------------
IRAK-Un_bp-2_Smoe  Q----Q-------RTLD--PTE--------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    -------AF-QC-YH-----------VNQTTAYNSDDDLGDYWQYPLDTDG-------L-
IRAK-Un_h_Smoe     E----LEF---A-TSVD--TSD--------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------WL-R--------------GPADRCFMLVNASSTW--EE-SE---TSCR------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    --------D----NELVEFP----W-MITV--G---YDYFPEVS-SK---NSCLQ-----
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  -CGRP---------------------------------------D-Y-------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    -SGRY--------------------------------------------------T----
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  --------A----FALRHLR----Y-SLQV--R---NFYW--PKSAQ---DPCS------
IRAK-Un_bk-1_Smoe  --------A----FALRHLR----Y-SLQV--R---NFYW--PKSAQ---DPCS------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    --------K-----V---------------------RLYFT-------------------
IRAK-Un_bg_Smoe    ------------------------G-TSLQ--YVSFLA-----F---YSS----------
IRAK-Un_cj_Smoe    ----PGWRA----LAMRQAIVHLC-----L--H---VYYH--PRVIA---FPSGAFKVCH
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    --------T----WALLALKSAW-N-DMAE--H---LMSW--DPSKG---TPCGA-----
IRAK-Un_bv_Smoe    -----------------SL-----------------HHSW--RS----------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    GES---------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   -SPPP---------------------------------------S-H---HSCGHL----
IRAK-Un_bx-1_Smoe  ----------------ARLG----------------QHKE--SS----------------
LRR10a_d-2_Smoe    ------------------------S-SVTT--AGEYLQSW--DF-NTSAANICN------
IRAK-Un_cz_Smoe    -----GWL-R--------------GPADRCFMLVNASSTW--EE-SE---TSCR------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    --FTR---------------------------------------V-A---S---------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ----------------ARLG----------------QHKE--SS----------------
IRAK-Un_am-1_Smoe  -CGRP---------------------------------------D-Y-------------
IRAK-Un_bj-2_Smoe  --------A----AILLDVK----R-GLDP--RGEVLASW--VA-GK---DPCGA-----
IRAK-Un_bj-1_Smoe  --------A----AILLDVK----R-GLDP--RGEVLASW--VA-GK---DPCGA-----
RKF3_a-2_Smoe      --------VGAFSSTLDHCR----R-SPPG-------------KNSS---DCCS------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    --------A----YAMRHLR----Y-SLRI--R---DFYW--PK-TR---DPCL------
IRAK-Un_t_Smoe     --------A----YAMRHLR----Y-SLRI--R---DFYW--PK-TR---DPCL------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  --------V----EALRVFGSRIG-----L------SPAW--NFS-V---DPCSG-----
IRAK-Un_bp-2_Smoe  --------V----EALRVFGSRIG-----L------SPAW--NFS-V---DPCSG-----
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    -SGRW--------------------------------------------------A----
IRAK-Un_h_Smoe     --------I----AALRSFAAHIRH-DPSG--A---LRSW--RRD-E---EACT------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ---------------------------------------------------N--------
IRAK-Un_ca_Smoe    -----------------------------SS--S--------------------------
IRAK-Un_am-2_Smoe  -----------------------------------------------------AI-----
IRAK-Un_da_Smoe    -----------------------------KSGT---------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    -----------------------------AA-----------------------------
IRAK-Un_dq_Smoe    -----------------------------AA-----------------------------
IRAK-Un_dh_Smoe    -----------------------------------------------------GYWSNTT
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    -----------------------------RMGSSSRRSRRRRDPVALVCSIFFS-WVFA-
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    RLRFHSHALGSRFFLLSSRMKCGRRTRQERMGSSSRRSRRRRDPVALVCSIFFS-WVFA-
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   -----------------------------------------------------KL-----
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  -----------------------------------------------------AI-----
IRAK-Un_bj-2_Smoe  ---------------------------------------------------E--------
IRAK-Un_bj-1_Smoe  ---------------------------------------------------E--------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    -----------------------------FT-PPPRRFCRRGRA----------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ---------------------------------------------------LYG-WNNTA
IRAK-Un_bp-2_Smoe  ---------------------------------------------------LYG-WNNTA
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    -----------------------------------------------------GYWSNTT
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------NRSGHLASIT---SDAE-----------------------------VAF-----
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    -----S---------SC-------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ---------------LCR------QGNLELQALNGRYSIQRIDRESRNI-----------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ---------------YIE------LGDITFQLWFLTYD-------ARNFTLSLVA-----
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------AWRG----IQCD-EQGR-----------------------------VVG-----
IRAK-Un_bk-1_Smoe  ------SWRG----IQCD-EQGR-----------------------------VVG-----
IRAK-Un_ck_Smoe    --------AS----SSCVPGAGCPRA---LL-----------------------VFNISA
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ----------------C-------------------------------------------
IRAK-Un_cj_Smoe    --------AS----SSCVPGAGCPRA---LL-----------------------VFNISA
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    -----QGWVG----IKCR-RDNST-G---LV--------------------QVVS-----
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    --------------------------------------------SPSSI-----------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ---------------HCE------HGTLKLKISAASY-------RVLGF-----------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    -------FLG----VQCL-HPSEI---------------------------KVYS-----
IRAK-Un_cz_Smoe    ------NRSGHLASIT---SDAE-----------------------------VAF-----
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ---------------ACS------D-------------------RSEN------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ---------------MCR------QGNLELQALNGRYSIQRIDRESRNI-----------
IRAK-Un_bj-2_Smoe  -----DGFVG----VACD-SRGR-----------------------------VTN-----
IRAK-Un_bj-1_Smoe  -----DGFVG----VACD-SRGR-----------------------------VTN-----
RKF3_a-2_Smoe      ------ALLT------------------------------------------TFG-----
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   --------AG----AQCVPSRGCT-A---VA-----------------------FFNFT-
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ---------R----E---------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------DWRG----VLCE--NGR-----------------------------VVS-----
IRAK-Un_t_Smoe     ------NWRG----VLCE--NGQ-----------------------------VVS-----
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  PAERYQPASG----VQCD-CSGNS-S---VC-----------------------HVLR--
IRAK-Un_bp-2_Smoe  PAERYQPASG----VQCD-CSGNS-S---VC-----------------------HVLR--
IRAK-Un_k-1_Smoe   --------AG----AQCVPSRGCT-A---VA-----------------------FFNFT-
IRAK-Un_bd_Smoe    ---------------YIE------LGDITFQLWFLTYD-------ARNFTLSLVA-----
IRAK-Un_h_Smoe     ------AWSG----VECS-WIHGS-Q---GF--------------------RVVS-----
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    VK----------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    M-------REPTQEWELYRPVVLWTANRDRYFGEGATLD--FGADG------------EL
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  IH----------------------------------------------------------
IRAK-Un_bk-1_Smoe  IH----------------------------------------------------------
IRAK-Un_ck_Smoe    V-------DP--------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    V-------DP--------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    IVLPKASLD------------------------------------------------EIG
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    LS----------------------------------------------------------
IRAK-Un_cz_Smoe    VK----------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  VS----------------------------------------------------------
IRAK-Un_bj-1_Smoe  VS----------------------------------------------------------
RKF3_a-2_Smoe      I-----------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   --------QN--------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    IY----------------------------------------------------------
IRAK-Un_t_Smoe     IY----------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  L-------RDSSGNWEL---------------------LFSFRSEPWSKHDHWYTSSGIG
IRAK-Un_bp-2_Smoe  L-------RDSSGNWEF---------------------LFSFRSEPWSKHDHWYTSSGIG
IRAK-Un_k-1_Smoe   --------QN--------------------------------------------------
IRAK-Un_bd_Smoe    M-------REPTQEWELYRPVVLWTANRDRYFGEGATLD--FGADG------------EL
IRAK-Un_h_Smoe     IR----------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------SHC---------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    IV------RENGLTV------------W-----STGT-----------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------LAGLKRTVAGMAQPSFSVDPLRSL
IRAK-Un_bk-1_Smoe  ------------------------------------LAGLKRTVAGMAQPSFSVDPLRSL
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    NLTQLTV---------------------------LYLQ----------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------LPG---------------------
IRAK-Un_cz_Smoe    ------------------------------------GHC---------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------LQG---------------------
IRAK-Un_bj-1_Smoe  ------------------------------------LQG---------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------LSGLKRTLVGMARPTLALDNLQGL
IRAK-Un_t_Smoe     ------------------------------------LSGLKRTLVGMARPTLALDNLQGL
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ILIQPTVLVRNSLVVHEVSLASHIFFSYVANTNNSNIG----------------------
IRAK-Un_bp-2_Smoe  ILIQPTVLVRNSFVVHEVSLASHIFFSYVANTNNSNIG----------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    IV------RENGLTV------------W-----STGT-----------------------
IRAK-Un_h_Smoe     ------------------------------------LP----------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ----------TGVFD--PCWVGAV----ISNTSRGVLWRWSDCHV---------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ----------------ILYRIDECS-------QVLTMW----------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    -----------AGKGVTEMCITNLGNLLLRNSTDHIIWQSF-------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  PLLRYLNASGFHARGLLPYWIGELS-------QLQVLDLSS-CS----------------
IRAK-Un_bk-1_Smoe  PLLRYLNASGFHARGLLPYWIGELS-------QLQVLDLSS-CS----------------
IRAK-Un_ck_Smoe    ------------------------S-------SLQVIYD---------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ----------IGLLQIVP------------------------------------------
IRAK-Un_cj_Smoe    ------------------------S-------SLQVIYD---------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ---------QNQLVGKIPAELCDLT-------ALEALYLHS-NYLTGPIPPELGRLKKLA
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ----------AGLHGSFPRG----------------------------------------
IRAK-Un_cz_Smoe    ----------TGVFD--PCWVGAV----ISNTSRGVLWRWSDCHV---------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ----------RGLEGSIPAAIGELS-------SLTALYLHY-------------------
IRAK-Un_bj-1_Smoe  ----------RGLEGSIPGAIGELS-------SLTALYLHY-------------------
RKF3_a-2_Smoe      GLADYLRRSGGFEFADLPTANACLK-------SFQAELDSHGT-----------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------E-------QLNTVFT---------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    PALRLLNATGFVMLGTLPDWIGQLS-------ALQVLDFSA-CS----------------
IRAK-Un_t_Smoe     PALRLLNATGFVMLGTLPDWIGQLS-------ALQVLDFSA-CS----------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ---------INRLRGPLPASFGRLT-------QLRSMGIGT-NY----------------
IRAK-Un_bp-2_Smoe  ---------INRLRGPLPASFGRLT-------QLRSMGIGT-NY----------------
IRAK-Un_k-1_Smoe   ------------------------E-------QLNTVFT---------------------
IRAK-Un_bd_Smoe    -----------AGKGVTEMCITNLGNLLLRNSTDHIIWQSF-------------------
IRAK-Un_h_Smoe     ---------KSLL-----------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ---------RWNFSFASSNCSSS-------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------NS--ST------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  --------------------------------VISSMPLA----------P---------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------DSPSDTIPMQ----------VAFKPGNRL-
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  -------GLQGSIPDSLGQLRQLKFLSLSGNNLTGGLPYS----------L---------
IRAK-Un_bk-1_Smoe  -------GLQGSIPDSLGQLRQLKFLSLSGNNLTGGLPYS----------L---------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    VLLLFSNELTGSIPETLANLTNLEALVLSENSLSGSIPPA----------I---------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    --------------------------------ISEPLPAD----------P----KVRFT
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   --------------------------------TR--------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ----------------LRKCSSLTGLDLSSNFFTGPIPAD----------L---------
IRAK-Un_cz_Smoe    ---------RWNFSFASSNCSSS-------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ---------------------------------FARIP----------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  --------------------------------VISSMPLA----------P---------
IRAK-Un_bj-2_Smoe  ------------------------------NSLSGSIPSS----------L---------
IRAK-Un_bj-1_Smoe  ------------------------------NSLSGSIPSS----------L---------
RKF3_a-2_Smoe      -----------------------------GTDFVRDCPFEPPMFVQSPICA---------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    --------INGSVPGGIGQLGSLRRLSLARNDLMGGIPAS----------I---------
IRAK-Un_t_Smoe     -----------------------------INGLDGSV-----------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  --------------------------------LTGSLPPE----------I---------
IRAK-Un_bp-2_Smoe  --------------------------------LTGSLPPE----------I---------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------DSPSDTFPIQ----------VAFKPGNRL-
IRAK-Un_h_Smoe     ---------EG-------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    -----------LSSM-------------------------------------F-------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ---------ASCTTLDAI---N-PSP-ASGG----------------------SGGLVLN
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------VSWASLKD-SSRG----------------------SYSLAME
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ---------GNLVALEAL---N---LSSNG----------------------LSGGI---
IRAK-Un_bk-1_Smoe  ---------GNLVALEAL---N---L----------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    --------------R-------------------------------------L-------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ---------GSFPVLRVL---Y---LDSNNLSGLIPPEIGLLPCLQKLFSNNLQGPI---
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    RTAFCSDSLVQAVDLEQI---N-ML-----------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------SNVIII---D-PQG-CGGG----------------------GGAGVGG
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ---------CQM------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ---------SCCKRIDALVGIA-AAQ-HANS----------------------SGDLCLS
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ---------ASCTTLDAI---N-PSP-ASGG----------------------SGGLALN
IRAK-Un_bj-2_Smoe  ---------ASLTGLTDV---Y---LNVNK----------------------LSGAI---
IRAK-Un_bj-1_Smoe  ---------ASLTGLTDV---Y---LNVNK----------------------LSGAI---
RKF3_a-2_Smoe      ---------GVMNISDWK---R--------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ---RCCH-----------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ---------GNLSRLELL---D---LSGNM----------------------LSGVL---
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ---------GNLRFLEQL---Y---MDSSGL----------------------SGEI---
IRAK-Un_bp-2_Smoe  ---------GNLRFLEQL---Y---MDSSGL----------------------SGEI---
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------VSWASPKD-SSQG----------------------SYSLAME
IRAK-Un_h_Smoe     -------------------------------------------------------EL---
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ---QSQAFNVTSSNTILFLNCSSI------------LLRSPLNCS------------SSS
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ---ENRLALYFNS----------------------------------------------E
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ----------------------------------P-------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ----------------------------------P-------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    --------KQQLQNAIV-------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   AATAPSSFTI-SNNTNYALSFGNL------------LML--YGCTNNTACYNNCNFNSRA
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ---KPAAS-LCLSSLVAALDSNGVHPQASRACGVPMSLRGQCQCK------------AAA
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ---QSQAFNVTSSNTILFLNCSSI------------LLRSPLNCS------------SSS
IRAK-Un_bj-2_Smoe  ----------------------------------P-------------------------
IRAK-Un_bj-1_Smoe  ----------------------------------P-------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ----------------------------------P-------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ----------------------------------P-------------------------
IRAK-Un_bp-2_Smoe  ----------------------------------P-------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ---ENRLALYFNS----------------------------------------------E
IRAK-Un_h_Smoe     ----------------------------------S-------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  VCHRYIDSTPS----ASACRGDN-LCCSFTAGGS--------S-----------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    VYWSF-----ESDGGDPGS-------------SDLFAAVCWQR-----------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ---------GS--------------------FQA--------MRRLVTLDVSRNLLDGLP
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ---------PE--------------------IGN--------LQSLEILELSS-------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    -----------------------AANKAKES-----------A-----------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   VHWPY-----AA-GGQHGCGVTP-QCCYDLQFAS--------L-----------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------LPYL--------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    RV-RDIVGAPG-------FEGVVASCESFGGGEM--------N-----------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  VCHRYIDSTPS----ASACRGDN-LCCSFTAGGS--------S-----------------
IRAK-Un_bj-2_Smoe  ---------SQ--------------------LTS--------LRNLQALQLCC-------
IRAK-Un_bj-1_Smoe  ---------SQ--------------------LTS--------LRNLQALQLCC-------
RKF3_a-2_Smoe      ---------------------------------------------VVAP-----------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ---------PE--------------------LGR--------MASLRD------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ---------PE--------------------LGS--------LQRLQILSISD-------
IRAK-Un_bp-2_Smoe  ---------PQ--------------------LES--------LQRLQILSISD-------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    VYWSF-----ESDGGDPGS-------------SDLFAAVCWQT-----------------
IRAK-Un_h_Smoe     ---------PR--------------------LGL--------LSELRVLDLSA-------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    -------------------------------------------------GCVNLGEY---
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  RLGSGDGGGVNGSQPWFERIEVL-----------------------------DLSSNRIN
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    -----------------------------------------------------------R
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    --------------------------------------------------------NQLS
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    -------------------------------------------------VKLDLSQNNIS
IRAK-Un_cz_Smoe    -------------------------------------------------GCVNLGEY---
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  --------------------------------------------------------NDLS
IRAK-Un_bj-1_Smoe  --------------------------------------------------------NDLS
RKF3_a-2_Smoe      -----------------------DLDRALERSCGGDLSSALRCQSCTD------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ----------------------LDLSGNIF---SGPIPASLAVSSSSSLRSVRLSDNRLD
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  --------------------------------------------------------NNFN
IRAK-Un_bp-2_Smoe  --------------------------------------------------------NNFN
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     --------------------------------------------------------NRLS
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    -------------------CLSVSSMHGLVR-----------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    --------------------------DSLYSTPF--------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  -----------TSHTIR-TRTDG-------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ----------NG---LMSLDLQRNA---SMPG--------------------YEGFLSA-
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  GSLPPELGKLAS---LRVLDLSRNSLGGTIPAGIGSL-----------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    --------RFST---SSQLVSQYN-----------------QLGSGNN---SAQIFIPFD
IRAK-Un_cn_Smoe    --------------------------ETIASSDM--------------------------
IRAK-Un_bg_Smoe    PLPP--------------------------------------------------------
IRAK-Un_cj_Smoe    --------RFST---SSQLVSQYN-----------------QLGSGNN---SAQIFIPFD
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    GGIPPELGNMTS---LVHLDLQFNNLSGPIPPDISLLSRLEVLSLGYN---RLSGAIPYE
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    -----------DAETLR-SQ----------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ----------TA---LRDIDLGS-------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    GIIPQDLSQCLY---LNQLRLQRNRLEGGIPGQIGL------------------------
IRAK-Un_cz_Smoe    -------------------CLSVSSMRGLVR-----------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    -----------SSRCSR-CSAA--------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  -----------TSHTIR-TRTDG-------------------------------------
IRAK-Un_bj-2_Smoe  GPIPDALGHLGL---LNLLALQHNHLDGRIPASL--------------------------
IRAK-Un_bj-1_Smoe  GPIPDALGHLGL---LNLLALQHNHLDGRIPASL--------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   --------TFSV---NFAQLQQYN-----------------DLRSQDFVQAGQFIKIPFQ
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    GSVPENLTGWST---LQELALGKNLLAGELPGALQDL-----------------------
IRAK-Un_t_Smoe     ---PENLTGWST---LQELVLGKNLLAGELPGALQDL-----------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  GSV-DVLGNLSS---LQELTMEGNRFRGQLPSSLGALQNLTKLYIGDV---SAGARIPES
IRAK-Un_bp-2_Smoe  GSI-DVLGNLSS---LQELTMEGNRFRGQLPSSLGALQNLTKLYIGDV---SAGARIPES
IRAK-Un_k-1_Smoe   --------TFSV---NFAQLQQYN-----------------DLRSQDFVQAGQFVKIPFQ
IRAK-Un_bd_Smoe    ----------NG---LMSLDLQRNA---SMPE--------------------YQGFLSA-
IRAK-Un_h_Smoe     GLIPDEIAQLPK---LRSIDLSSNRLVGRIPTGNGNGNSLRS------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ---------------------------------LKMSMA--------EISR---------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ----------------------------ARLTKMDLSRNNLTGFLP-RELSSLAR-MEAL
IRAK-Un_bk-1_Smoe  -----------------------------SLTKMDLSRNNLTGFLP-RELSSLAR-MEAL
IRAK-Un_ck_Smoe    CQCVRK----VLQHNFPYEIAP-DDTTL----F-IIAQEKFQGLTRDDWIAEATP-LKD-
IRAK-Un_cn_Smoe    ---------------------------------IRVYHP--------DHHKVLAEYSGKA
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    CQCVRK----VLQHNFPYEIAP-DDTTL----F-IIAKEKFQGLTRDDWIAEATP-LKD-
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    VGLLFSLRLMYLPNNSLSGHIPADLEHLKMLTQVDLDFNELTGSIP-KQLGFLPN-LQAL
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ----------------------------------------------------LPR-LRD-
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  --------------------------------------------------GQLSS-LKHL
IRAK-Un_bj-1_Smoe  --------------------------------------------------GQLSS-LKHL
RKF3_a-2_Smoe      -----------------------------DVTRVVLELQGL-------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   CGCING----RLAHTFVFNNVS-QSDSF----A-SINTRYYHELSNVASMSVDP---SL-
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ----------------------------RNLTLLDLSLNNFTGTIP-PGLASLSS-LQSL
IRAK-Un_t_Smoe     ----------------------------RNLTLLDLSLNNFTGTIP-PGLASLSS-LQSL
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  LNRLSLLSRLSLRNCELSGSIP-DFSNMTRLVFIDLSFNQLTGVIP-SSLASLPS-LENL
IRAK-Un_bp-2_Smoe  LNRLSLLSRLSLRNCELSGSIP-DFSNMTRLVFIDLSFNQLTGVIP-SSLASLPS-LENL
IRAK-Un_k-1_Smoe   CGCING----RLAHTFVFNNVS-QSDSF----A-SINTRYYHELSNVASMSVDP---SL-
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    -IPE--------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  --------------------------------------------LGCSAYVS--------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    --------------------------------------------ESCQSSAP--------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  VLSHNEFY----------------------------------------------------
IRAK-Un_bk-1_Smoe  VLSHNEFY----------------------------------------------------
IRAK-Un_ck_Smoe    -------------------------------KNTIFAGLNVKVPVNCSCGNPDVDRSYG-
IRAK-Un_cn_Smoe    ELPRQAFK----------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    -------------------------------KNTIFAGLNVKVPVNCSCGNPDVDRSYG-
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    FLQQNKLQG-----KHVHFVSDQ-------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   --------------------------------------------FNCSGFSS--------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  --------------------------------------------LGCSAYVS--------
IRAK-Un_bj-2_Smoe  DLSFNSLS----------------------------------------------------
IRAK-Un_bj-1_Smoe  DLSFNSLS----------------------------------------------------
RKF3_a-2_Smoe      --SNSTSV----------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   -------------------------------NGQLFPGQPVNVLVNCSCGDPRFP-VFG-
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    DLSNNTFY----------------------------------------------------
IRAK-Un_t_Smoe     DLSNNTFY----------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  NIIWNSFNVSNAQGQ---TAAEMNCLETRMGCNAVDAGRNFELSIN--CGGPAVS-ADGM
IRAK-Un_bp-2_Smoe  NIIWNSFNVSNAQGQ---TAAEMNCLETRMGCNAVDAGRNFELSIN--CGGPAVS-ADGM
IRAK-Un_k-1_Smoe   -------------------------------NGQLFPGQPVNVLVNCSCGDPRFP-VFG-
IRAK-Un_bd_Smoe    --------------------------------------------ESCQSSAP--------
IRAK-Un_h_Smoe     ----------------------A-------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  V-----------VR------MD----QS--LDPRQ------WS--------------YGV
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    V-----------KR------FE----ML--RNTQN------FT--------------YGT
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ----------------------------------------------------------GS
IRAK-Un_bk-1_Smoe  ----------------------------------------------------------GS
IRAK-Un_ck_Smoe    -------------------------------------------LFA-TYVVQPGDT----
IRAK-Un_cn_Smoe    ----------------------------------------------------------GP
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    -------------------------------------------LFA-TYVVQPGDT----
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    -----------------------------------------------SAMDLSGNYLSGP
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    --------------------------EA--REKAD------WA--------------L--
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   L-----------VTTFKEKGED----VS--VEAREGLGLEWW------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    A-----------TR------LAASIAA---------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  V-----------VR------MD----QS--LDPRQ------WS--------------YGV
IRAK-Un_bj-2_Smoe  ----------------------------------------------------------GP
IRAK-Un_bj-1_Smoe  ----------------------------------------------------------GP
RKF3_a-2_Smoe      ----------------------------------------------------------GQ
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   -------------------------------------------LFM-TYPGQRGDL----
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ----------------------------------------------------------GP
IRAK-Un_t_Smoe     ----------------------------------------------------------GP
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  TFTEDSSSLSEAV--------------YYSNSSQS------WAVSSTGYVDFNGNTFNS-
IRAK-Un_bp-2_Smoe  TFTEDSSSLSEAV--------------YYSNSSQS------WAVSSTGYVDFNGNTFNS-
IRAK-Un_k-1_Smoe   -------------------------------------------LFM-TYPGQRGDL----
IRAK-Un_bd_Smoe    V-----------KR------FE----LL--RNTQN------FP--------------YGT
IRAK-Un_h_Smoe     ------------A--------------AFA-----------------GNPGLCGWPLD--
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  E-----------------LG--W-------------A-----------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    FL-KLNTMGDLTVYTWTTTGNYWYAAFNLSSNF-SCF-----------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  LPEGLTALKSMAF-------------LDLSSDYLNGTVPDEITYTTALAGNCFENV---A
IRAK-Un_bk-1_Smoe  LPEGLTALKSMAF-------------LDLSSDYLNGTVPDEITYTTALAGNCFENV---A
IRAK-Un_ck_Smoe    -------------------------------------------------------LSTIS
IRAK-Un_cn_Smoe    ITLEFSS-----------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------PPPE--------------------
IRAK-Un_cj_Smoe    -------------------------------------------------------LSTIS
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    VPPELGNCSLLTV-------------LNLADNLLTGTVPEELGSLSFLASLVLENNQLEG
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------KRVNW-------------R-----------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   L-----------------NG--S-------------C-----------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    --------------------------FNVADNRLSGPIPYTFHAF---------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ----------------------P-------------N-----------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  E-----------------LG--W-------------A-----------------------
IRAK-Un_bj-2_Smoe  IPAALNNLAQITV-------------LDVRSNKLSGYVPAGKRKLLIASNSNL-------
IRAK-Un_bj-1_Smoe  IPAALNNLAQITV-------------LDVRSNKLSGYVPAGKRKLLIASNSNL-------
RKF3_a-2_Smoe      QCVYVSCLYAAGV-------------VN----KLGPKEPSTAV-----------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   -------------------------------------------------------VRDVA
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    LPAAVSSLRGLLV-------------LNVSDNFLNDTVPAGTVAGAILSENCFVNA---S
IRAK-Un_t_Smoe     LPAAVSSLRGLLV-------------LNVSDNFLNDTVPAGTVAGAILSENCFVNA---S
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  -------------------------------------------------------VPTAA
IRAK-Un_bp-2_Smoe  -------------------------------------------------------VPTAA
IRAK-Un_k-1_Smoe   -------------------------------------------------------VRDVA
IRAK-Un_bd_Smoe    FL-KLNTMGDLTVYTWNTTGDYWYAAFNLSSNF-SCF-----------------------
IRAK-Un_h_Smoe     -----RECP------------------------------PSSI-----------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  RQRYQKDCQR-FYTSRGLELS---------------------------------------
IRAK-Un_bk-1_Smoe  RQRYQKDCQR-FYTSRGLELS---------------------------------------
IRAK-Un_ck_Smoe    ARFKV-------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ARFKV-------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    KVPSSLGNCSGLIAIRL---GHNRLTGTIPESFGLLTHLQTFDMSFNGL-----------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   TRFNT-------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    GQRSLSDCQA-FYAARGLVFQ---------------------------------------
IRAK-Un_t_Smoe     GQRSLSDCQA-FYAARGLVFQ---------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  TRVTGTRDSSLYQTA----------------------RASPTSLKYFGLGMVNGPYQVDL
IRAK-Un_bp-2_Smoe  TRVTGTRDSSLYQTA----------------------RASPTSLKYFGLGMVNGPYQVDL
IRAK-Un_k-1_Smoe   TRFNT-------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     -----ITTKKHYSSARRALLQ---------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ---------------------------------------------PPRELQCGG------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ---------------------------------------------LPQAQECGPYG----
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    --------------------------PDQQLLQRFNPHI-DFQRL---------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    --------------------------PDQQLLQRFNPHI-DFQ-----------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    -------------------------------TGK--------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ---------------------------------------------------CYR------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ---------------------------------------------PAAAGVAAA------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ---------------------------------------------PPRSCQEAV------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ---------------------------------------------PPRELQCGG------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   --------------------------TVQN-LTNYNPSLGNINSL---------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  HFAEIVIQDDSSGWTGLGRRFFDVYIQGSRVLQD----------FDIRAEANGSYIAIVR
IRAK-Un_bp-2_Smoe  HFAEIVIQDDSSGWTGLGRRFFDVYIQGSRVLQD----------FDIRAEANGSYIAIVR
IRAK-Un_k-1_Smoe   --------------------------TVQN-LTNYNPSLGNINSL---------------
IRAK-Un_bd_Smoe    ---------------------------------------------LPQAQECGQYG----
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ---------------ICNKGDGQCCPGSLNYQGGVCGARRPLPLDPRRCEPHEIVRMEGV
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  --------------------GEVGM------------LP---------------------
IRAK-Un_bk-1_Smoe  --------------------GEVGM------------LP---------------------
IRAK-Un_ck_Smoe    -------------------------------------IAQSIVF----------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    -IPPQIGLCKSLLSLALNDNALKGS------------IPTELTTLPILQF----------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    --------------------------------------------------------QKSY
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      -----------------------CV------------LG---------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   -------------------------------------SPDDRLF----------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    -------------------NASSFN------------LP---------------------
IRAK-Un_t_Smoe     -------------------NASSFN------------LP---------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  PF-PAQVSNNVLEIHLLWRGRGTCC------------SPAPLSFGPLISA----------
IRAK-Un_bp-2_Smoe  PF-PAQVSNNVLEIHLLWRGKGTCC------------SPAPLSFGPLISA----------
IRAK-Un_k-1_Smoe   -------------------------------------SPDDRLF----------------
IRAK-Un_bd_Smoe    ---------------ICNKGDGQCCPSSLDYQGGVCGARRPLPLDPRRCEPHEIVRMEGV
IRAK-Un_h_Smoe     -------------------DGATAP------------SPSQ-------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  --------------EGD----DCDT-------EDSSCRMDSTSGGFRCLCDPGYVWN---
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    DYFSTNFSREVPVVDESECRRRCE--------ENCSCMAA-FFKEKSCF-------QTHE
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    DFMAFQAEILMRAVE---------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   --------------EGS----LCA--------RNAMCVA-GTFGGHTCRCEEK-------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    --------------FVA----LASFEDFKSAMHKASCL-----------------FQLQP
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  --------------EGD----DCDT-------EDSSCRMDSTSGDFRCLCDPGYVWN---
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    DYFSTNFSTELPVVDESECRRRCE--------ENCSCMAA-FFKEKSCF-------QTHE
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    PIQSMITGEYT-------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ---------------V--------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------ASMAHNKLTGVIPPTLDSLAQLQVLNLEGNMLSGSIPAKVGAIRDLRE
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    -----------------------EDNQR--------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    --PKKLTGKFLSPRT------RPEDDVS--------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ----SDEGVC--------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ---------------I--------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------IRVR--------------------------------------------
IRAK-Un_bp-2_Smoe  ------------IRVR--------------------------------------------
IRAK-Un_k-1_Smoe   ---------------I--------------------------------------------
IRAK-Un_bd_Smoe    PIQSMITGEYT-------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    -------------------------------------GLL--------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ----------TATPIVGSSLG---------------------------------------
IRAK-Un_bk-1_Smoe  ----------TATPIVGSSLG---------------------------------------
IRAK-Un_ck_Smoe    -------------PA---KDS---------------NGLY--------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    LVLSSNRLSNNI-PS---SLGSLLFLTVLLLDKNNFTGTIPPTLCNCSSLMRLNLSSNGL
IRAK-Un_bv_Smoe    ----------WP-RC---------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------EYNT--------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ----------SP-PG---LLE---------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------MSLL--------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ----------SP-PG---LLE---------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ----------LTPPS---------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   -------------PA---TLA---------------NGTY--------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ----------TPM-----------------------------------------------
IRAK-Un_t_Smoe     ----------TPM-----------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  -------------PE---FDT---------------SGLI--------------------
IRAK-Un_bp-2_Smoe  -------------PE---FDT---------------SGLI--------------------
IRAK-Un_k-1_Smoe   -------------PA---TLA---------------NGTY--------------------
IRAK-Un_bd_Smoe    -------------------------------------GLL--------------------
IRAK-Un_h_Smoe     --------SPTP-PS---SNG-----------------SE--------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ----------------------ENC--GDRH----RF-----VC----------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ----------------------------------------VPS-----------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    --------------------------K---------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    --------------------------P--------------P------------------
IRAK-Un_cn_Smoe    -------------------------QTGDGDGWALNYVMDSPQ-----------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    VGEIPRLGSFLRFQADSFARNTGLCGP--------------PL-----------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    --------------------------A---------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    -------------TELSFAGNEALC--GAPL----GA-----NC----------------
IRAK-Un_cz_Smoe    ----------------------ENC--GDRH----RF-----VC----------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    --------------------------P---------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------ETGFAYSNNTGLCGVGFPS---------LPYCSGSGASSLQRPQPFGA
IRAK-Un_bj-1_Smoe  ------------ETGFAYSNNTGLCGVGFPS---------LPYCSGSGASSLQRPQPFGA
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   --------------------------P--------------P------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  --------------------------P--------------A------------------
IRAK-Un_bp-2_Smoe  --------------------------P--------------A------------------
IRAK-Un_k-1_Smoe   --------------------------P--------------P------------------
IRAK-Un_bd_Smoe    --------------------------K---------------------------------
IRAK-Un_h_Smoe     --------------------------A--------------PS-----------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------V-LA-TKE-GEC--I---RATNRK--AYLIVLIAVSCL-IL--VTALAIVIWLL
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    -------NKRE-ESGRSSSKR---KILRKP--WP--AAYVVAAI-LL-VAAAVMVLAVWK
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ----------------------------SDEGVCSSTGLASGGAVLA-A-I-LAT-AIFV
IRAK-Un_da_Smoe    -----------------------------------TLDEAR---GLM--VSLFFL-AVWP
IRAK-Un_dg_Smoe    ------------------------------------AASVISAA-V--FVVSIFQ---LL
IRAK-Un_dj_Smoe    --------------------------------------GVFGGL-GF-AFFLMLIE--L-
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ---------------VAK-TS---VGDSGNQA--LVYRVALPVLLPA-FVLLVAL-LAWI
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  -----------GR--LAGSSK---KSKKQH--VAAILGGILGSF-GF-IIAVVAIVHAFQ
IRAK-Un_bk-1_Smoe  -----------GR--LAGSNK---KSKKQH--VAAILGGILGSF-GF-IIAVVAIVHAFQ
IRAK-Un_ck_Smoe    ---------------YS--------SG-VR--RSTIVGASVGSILAV-LLAAAAG-MAFF
IRAK-Un_cn_Smoe    -------TT----TQLSYTAR---SAAVTA--LGAVCGVFVPGV-VF-L-GAVVLCCNFS
IRAK-Un_bg_Smoe    --------EQ-TPA-PPPLFS---KSRSIG--SGAIAGIAIGAL-AA-ISISIAV---LI
IRAK-Un_cj_Smoe    ------------------------------------------------RLIAQS--I-VF
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------RAS---SSGGPS--IPVIVGLSLAAAAGL-LFLITV--VACV
IRAK-Un_dk_Smoe    -------PF----------PR---CSAADPTG-EAVLGPAVAV-LAV-LVFVVLL-AKWF
IRAK-Un_bv_Smoe    ----------------CSSR----------------------SSAGLSKIPGAN--LASH
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ---------------KKL-DE---ESQK--RA---------EALTLV-N-T-MKK-ALVD
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   -------------------------FHGDPYRAGCRPGILAGATVLA-AVV-IAL-ALLA
IRAK-Un_bx-1_Smoe  -----------QQ--AASNQR---RSQRRP--TAAIVSSA--VGAGF-LLLVLV--LVIL
LRR10a_d-2_Smoe    --------KG-GAA-GAAAAH---RAARAR--TAVVAGVAAGGT-LA-LLAACFLCCWVA
IRAK-Un_cz_Smoe    ------V-LA-TKE-GEC--I---RATNRK--AYLIVLIAVSCL-IL--VTALAIVIWLL
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ---------------------------------------------LG-P--SGVV-FFVL
IRAK-Un_do_Smoe    ---------------DPI-NK---LAHQSPSPVTIVLAIGIGITG-A-TVA-ILL-VLVL
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  -----------QQ--AASNQR---RSQRRP--TAAIVSSA--VGAGF-LLLVLV--LVIL
IRAK-Un_am-1_Smoe  ---------------SST-GRDRFLARFSYTKMLALPGLASGGAVLA-A-I-LAT-ALFV
IRAK-Un_bj-2_Smoe  PGNAATVAQTV-AKRAPLSTN---SSSRIP--QMAVIGGVVAVT-GG-VLLAM--LMSFV
IRAK-Un_bj-1_Smoe  PGNAATVAQTV-AKRAPLSTN---SSSRIP--QMAVIGGVVAVT-GG-VLLAM--LMSFV
RKF3_a-2_Smoe      ----------------AGAPG---GSRGTD--AKLYIGIGVGGS-AI-ALAGALIACIFL
IRAK-Un_bo-2_Smoe  -------------------------GHKSH--AGAIAGAVVGAV-VL-VAISIG-LVSLC
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ---------------FSAGSD---GSGSSN--TGLIAGVAVGV-GVV-VLAAAVS-LVWF
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    --------------------------------GFVIAGN-------------------CC
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ----------------PTRRS---KSKPRH--LAVILGGTFGGL-GL-VLLVAALV--LL
IRAK-Un_t_Smoe     ----------------PTRRS---KSKPRH--LAVILGGTFGGL-GL-VLLVAALV--LL
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ---------------T---PS---PSS-DS--KVVPIGVGVGVS-VA-VVFLAAI-FAIL
IRAK-Un_bp-2_Smoe  ---------------T---PS---PSS-DS--KVVPIGVGVGVS-VA-VVFLAAI-FAIL
IRAK-Un_k-1_Smoe   ---------------FSAGSD---GSGSSN--TGLIAGVAVGV-GVV-VLAAAVS-LVWF
IRAK-Un_bd_Smoe    ---------------VAK-TS---VGDSGNQA--LVYRVALPALLPA-LVLLVAL-LAWI
IRAK-Un_h_Smoe     -------PSAAAAGSSPRHKG---RSRARRWGIGAALGVIAGSVSGV-LVGIIAR-AGII
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ----------------------------RR--RIRTIAVSVGAS-LV-GVALVIL-CVVL
IRAK-Un_ap-2_Smoe  ----------------------------RR--GIRTIAVSLGAS-LV-GVALVIL-CVVL


IRAK-Un_aw_Smoe    VYRRKRRRRRSRRA----------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    FYKAKRLRAGQSE-----------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  VHKRRSRRAMKRAS----------------------------------------------
IRAK-Un_da_Smoe    IRWRRKSRKGKSRSVHDIPSTPKDIPEVRTEPSARISRRPPSFDTFEYSVRRNSSSFRIF
IRAK-Un_dg_Smoe    IMIHRRLKAGKHHV----------------------------------------------
IRAK-Un_dj_Smoe    L-RRYGGRDGAGSS----------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    CWKKSLEKAGGESD-----------------------K----------------------
IRAK-Un_dp_Smoe    --RKELHRQCSKTQ-----------------------L----------------------
IRAK-Un_bk-2_Smoe  LRDRRRRRRSSSS-----------------------------------------------
IRAK-Un_bk-1_Smoe  LRDQRRRRRSSSS-----------------------------------------------
IRAK-Un_ck_Smoe    LWKRKHLQQDEKND-----------------------RLP--------------------
IRAK-Un_cn_Smoe    VLPVKRSKIQPSE-----------------------------------------------
IRAK-Un_bg_Smoe    LWRHKQVKQRDD------------------------------------------------
IRAK-Un_cj_Smoe    VPAKDE-----KND-----------------------RLP--------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    LSRRKGKAKSRSV-----------------------------------------------
IRAK-Un_dk_Smoe    HLRPVQVTYDPSE-----------------------------------------------
IRAK-Un_bv_Smoe    PRRRRRRARPRTL-----------------------------------------------
IRAK-Un_ay-2_Smoe  ------NSIV--------------------------------------------------
IRAK-Un_ay-1_Smoe  ------NSIV--------------------------------------------------
IRAK-Un_df_Smoe    EIRRRKEMENRIEL-----------------------Q----------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ARSRHHRRRLSTTF-----------------------R----------------------
IRAK-Un_bx-1_Smoe  VYRRVKRSSARTI-----------------------------------------------
LRR10a_d-2_Smoe    LGGQRRRRKSGAEL----------------------------------------------
IRAK-Un_cz_Smoe    VYRRKRRRRRSRRA----------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    RWRWRPRRKVSDS-----------------------------------------------
IRAK-Un_do_Smoe    LLQRKREESVPLWN-----------------------K----------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  VYRRVKRSSARTI-----------------------------------------------
IRAK-Un_am-1_Smoe  VHKRRSRRAMKRAN----------------------------------------------
IRAK-Un_bj-2_Smoe  WFRRHKQRISSTH-----------------------------------------------
IRAK-Un_bj-1_Smoe  WFRRHKQRISSTH-----------------------------------------------
RKF3_a-2_Smoe      FHRRRKKRELVQS-----------------------------------------------
IRAK-Un_bo-2_Smoe  LMRVRHWPSATSD-----------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   CMRRSKKKKVAKY-----------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    SIRHAAKAQISRE--------------------------P--------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    IR-KHERRPAREPP----------------------------------------------
IRAK-Un_t_Smoe     IR-KRERRPAREPP----------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  FIRKRRRLKYGQD-----------------------------------------------
IRAK-Un_bp-2_Smoe  FIRKRRRLKYGQD-----------------------------------------------
IRAK-Un_k-1_Smoe   FMRRSKKKKVAKY-----------------------------------------------
IRAK-Un_bd_Smoe    CWKKSLEKAGGESD-----------------------K----------------------
IRAK-Un_h_Smoe     VYKRARAKNGPI------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ILRKKRNRKASRE-----------------------------------------------
IRAK-Un_ap-2_Smoe  ILRKKRNRKASRE-----------------------------------------------


IRAK-Un_aw_Smoe    --------------P--S------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    --------------T--MG-N---------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  -----------------RA-QEL--A---------L------------------------
IRAK-Un_da_Smoe    KHGDVVESSSLDYSP--PVTDTEMAV---------S----Q-DSESN---S------GTT
IRAK-Un_dg_Smoe    --------------L--PV-AS---------------------------GG------G--
IRAK-Un_dj_Smoe    --------------S--GA-PIL--A---------D-------SSST---A------AA-
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    -----------------ED-EE--------------------------------------
IRAK-Un_dp_Smoe    -----------------EL-G---------------------------------------
IRAK-Un_bk-2_Smoe  --------------S--KD-DRG--S---------Q---------QT---G------GSM
IRAK-Un_bk-1_Smoe  --------------S--KD-DRG--S---------Q---------QT---G------GSM
IRAK-Un_ck_Smoe    -------------SP--AA-SST--V---------S----A-L-RKA---S------GVL
IRAK-Un_cn_Smoe    --------------E--KP-----------------------------------------
IRAK-Un_bg_Smoe    --------------E--QG-MIL--Q----------YIIFGVDVIVFHADS------G--
IRAK-Un_cj_Smoe    -------------SP--VA-SST--V---------S----A-L-RKA---SGTPTPSGVL
IRAK-Un_v-2_Smoe   ----------------------L--A---------K------------------------
IRAK-Un_de_Smoe    --------------S--EL-REP--A---------A----P-I-R-M---N------GLD
IRAK-Un_dk_Smoe    --------------N--VP-GK--------------------------------------
IRAK-Un_bv_Smoe    --------------C--RC-HT--------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    --------------C--K--AEA------------E------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   --------------SMRDA-KQL--A---------K------------------------
IRAK-Un_bx-1_Smoe  --------------S--PA-SE--------------------------------------
LRR10a_d-2_Smoe    --------------E--EE-LLD--N------------------AWL--RR------I--
IRAK-Un_cz_Smoe    --------------P--S------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    --------------E--SS-----------------------------------------
IRAK-Un_do_Smoe    --------------D--SA-LDV--W---------Q------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  --------------S--PA-SE--------------------------------------
IRAK-Un_am-1_Smoe  -----------------RA-QEL--A---------L------------------------
IRAK-Un_bj-2_Smoe  --------------D--SS-GG---IKVAIMDILSPEQTKSKSGGD---GGGK----GSS
IRAK-Un_bj-1_Smoe  --------------D--SS-GG---IKVATMDILSPEQTKSKSGGD---GGGK----GSS
RKF3_a-2_Smoe      --------------S--LV-----------------------------------------
IRAK-Un_bo-2_Smoe  --------------T--AS-SD-------------P------S-----------------
IRAK-Un_dc_Smoe    -----------------K--AEA------------E------------------------
IRAK-Un_k-2_Smoe   --------------P--MD-MEV--T---------S----A---DTK---H------GLM
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    -----------------AD-R-------------------------S-------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    --------------K--KS-DEA--M---------A----G--GAAA--GA------GAG
IRAK-Un_t_Smoe     --------------K--KS-DEA--M---------A----G--GAAA--GA------GAG
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  --------------E--ED-----------------------------------------
IRAK-Un_bp-2_Smoe  --------------E--ED-----------------------------------------
IRAK-Un_k-1_Smoe   --------------P--MD-MEV--T---------S----A---DTK---H------GLM
IRAK-Un_bd_Smoe    -----------------EE-EE--------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  --------------A--LS-----------------------------------------
IRAK-Un_ap-2_Smoe  --------------A--LS-----------------------------------------


IRAK-Un_aw_Smoe    --------------------------------------------SSMVPLSSLRLFTLDE
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    -----------------------------------------SCIIQPEFENSPRYFKLKE
IRAK-Un_ca_Smoe    -------------------------------------------------IPAMASRTLT-
IRAK-Un_am-2_Smoe  ------------------------------------------IMSNAGGGKTSRIFTAGE
IRAK-Un_da_Smoe    -----------------------------------V-SFTP-QQQVSSYLGWGNWYCLEE
IRAK-Un_dg_Smoe    -------------------------------------TKGKESLVKGAVRGHVLSFTLQE
IRAK-Un_dj_Smoe    -----------------------------------A-AAAE-LSVANLLRQVLRDFSYQQ
IRAK-Un_dm_Smoe    ------------------------------------------------EPIAIKQYMLKE
IRAK-Un_ag_Smoe    -------------------------------------------------AK-FASWSIYE
IRAK-Un_dq_Smoe    -------------------------------------------------ARFASSWSIYE
IRAK-Un_dh_Smoe    -------------------------------------------LEMSLRDCMPRRFTYKE
IRAK-Un_dp_Smoe    -------------------------------------------QSARKSLSQVRQFSFQE
IRAK-Un_bk-2_Smoe  RH------------------H-----------DQ-----EQ-ANVTVNLACIGEAFSFAQ
IRAK-Un_bk-1_Smoe  RH------------------H-----------DQ-----EQ-ANVTVNLACIGEAFSFAQ
IRAK-Un_ck_Smoe    RS----------------NIS-----------S--T-TSVR-SAISDIALEKSIEFSLHE
IRAK-Un_cn_Smoe    ------------------------------------------------RLHTRRQFSLEE
IRAK-Un_bg_Smoe    -------------------------------------SDMSEPLRNWEVPQGIEMFSLDQ
IRAK-Un_cj_Smoe    RS----------------NIS-----------S--T-TSVR-SAISDIALEKSIEFSLHE
IRAK-Un_v-2_Smoe   ------------------------------------------LVSRTGSSKAVTLFSYKD
IRAK-Un_de_Smoe    SSTI----------------LSDQFSTNHDHHA--VEIWHP-KPA-SVFHPGITKFSYKE
IRAK-Un_dk_Smoe    ----------------------------------------------MVVFVNNFVCDYDD
IRAK-Un_bv_Smoe    ----------------------------------------------------------RF
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------REANRQQLLKYTQFTFEE
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------LVSRTGSSKAVTLFSYKD
IRAK-Un_bx-1_Smoe  ----------------------------------------------QQSPIRLRRFSYRE
LRR10a_d-2_Smoe    -------------------------------------KSPSAVLVS-MFEQPIVKIRLSD
IRAK-Un_cz_Smoe    --------------------------------------------SSMVPLSSLRLFTLDE
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    --------------------------------------------V-YN-MGNPRLFTYNE
IRAK-Un_do_Smoe    ------------------------------------------GSGNKKALRALRRFKYSE
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  -------------------------------------------------VPQFREFSFEQ
IRAK-Un_av-1_Smoe  -------------------------------------------------VPQFREFSFEQ
IRAK-Un_bx-2_Smoe  ----------------------------------------------QQSPIRLRRFSYRE
IRAK-Un_am-1_Smoe  ------------------------------------------IMSNAGGGKTSRIFTAGE
IRAK-Un_bj-2_Smoe  LH----------------LVA-----------PLAM-QSINAPKSLVGSSMRSFQYRLEE
IRAK-Un_bj-1_Smoe  LH----------------LVA-----------PLAM-QSINAPKSLVGSSMRSFQYRLEE
RKF3_a-2_Smoe      -------------------------------------------GLSRMPNLGLIKFSFEE
IRAK-Un_bo-2_Smoe  --------------------------------------AQEGAIAAAVEAQHAKQFAFQE
IRAK-Un_dc_Smoe    ------------------------------------------REANRQQLLKYTQFTFEE
IRAK-Un_k-2_Smoe   QSTFLRVSYRFVNDAGLLHSP-----------S--V-GSVP-AGLSGFAVDKSVEFTYDE
IRAK-Un_bo-1_Smoe  --------------------------------------------AAAVEAQHAKQFAFQE
IRAK-Un_cb_Smoe    ---------------------------------------------GGFEGRNPLIGAFHE
IRAK-Un_cs_Smoe    ---------------------------------------------------QPMEFDPKG
IRAK-Un_cu_Smoe    AA----------------TTS-----------GTGQ-PVVP-PAVAVKMSSIGESFTFSQ
IRAK-Un_t_Smoe     AA----------------TTS-----------GTGQ-PVVP-PAVAVKMSSIGESFTFSQ
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  --------------------------------------------L-RSLEAKPNLYSYND
IRAK-Un_bp-2_Smoe  --------------------------------------------L-RSLEAKPNLYSYND
IRAK-Un_k-1_Smoe   QSTFLRVSYRFVNDAGLLHSP-----------S--V-GSVP-AGLSGFAVDKSVEFTYDE
IRAK-Un_bd_Smoe    -------------------------------------------LEMSLRDCMPRRFTYKE
IRAK-Un_h_Smoe     ------------------------------------------------IFFHKLTPKMLA
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    -------------------------------------------------------YTFST
IRAK-Un_ap-1_Smoe  --------------------------------------------W-LPPDCKARKYSYEQ
IRAK-Un_ap-2_Smoe  --------------------------------------------W-LPPDSKARKYSYKE


IRAK-Un_aw_Smoe    LRI-ATNNFGMEN---R-------L-------RGST-------------FKGIL-SDG--
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    -------------------------GRG---GFASV-------------YKGVI-D---N
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    LCE-IASNIERK------------LDE----D-LAL-------------FS----REL--
IRAK-Un_ca_Smoe    ------------K---L-------MESG---ATPSRSKPRKNPSAEKSQCPGITPLP--G
IRAK-Un_am-2_Smoe  MKR-ATNNFSKER---L-------LGTG---GFGEV-------------YKGTL-DDG--
IRAK-Un_da_Smoe    LEI-ATGGFSERN---I-------IGEG---GYGIV-------------YKGAV-SD--G
IRAK-Un_dg_Smoe    VEL-LSEGFS--N---L-------IGQG---STNRV-------------YKGIL-SDG--
IRAK-Un_dj_Smoe    LHQ-ATNGFAQGN---L-------LREG---LFAGT-------------LGG----D--G
IRAK-Un_dm_Smoe    LEE-AI-----GI---K-------IAEG---GFGYV-------------YRGTL-INR--
IRAK-Un_ag_Smoe    NRE-VLARYAVLD---P-------IGSG---AYSDV-------------YHGKRRDD--G
IRAK-Un_dq_Smoe    NRE-VLARYAVLD---P-------IGSG---AYSDV-------------YHGKRRDD--G
IRAK-Un_dh_Smoe    LEQ-ITGGFSK-----C-------LGQG---GYGSV-------------YRGSL-EDG--
IRAK-Un_dp_Smoe    MEL-ATNGFSENR---R-------LGDG---GFGTV-------------YAGTL-GGG-G
IRAK-Un_bk-2_Smoe  LQR-STQDFNPVN---L-------IKAG---HTGDL-------------YRGIL-DG--G
IRAK-Un_bk-1_Smoe  LQR-STQDFNPVN---L-------IKAG---HTGDL-------------YRGIL-DG--G
IRAK-Un_ck_Smoe    LVA-ATNNFNETN---K-------IGQG---GYGSV-------------YYGYF-RD--Q
IRAK-Un_cn_Smoe    LRE-ATMDFSPAN---V-------VSD----SDGNV-------------FRGTL-QDG--
IRAK-Un_bg_Smoe    ISK-ATSGFSKEC---E-------VGCG---GFGRV-------------YRGNL-EDG--
IRAK-Un_cj_Smoe    LVA-ATNNFNETN---K-------IGQG---GYGSV-------------YYGYF-RD--Q
IRAK-Un_v-2_Smoe   LER-ATKDFSPAQ---M-------LGHG---GHGTV-------------YKGKL-PDG--
IRAK-Un_de_Smoe    IQR-ATKNFT--T---L-------VGSG---AFGPV-------------YKATP-SPSSP
IRAK-Un_dk_Smoe    IVA-ATGGFDDSH---L-------LGKG---GFGAV-------------YDAVL-PD--G
IRAK-Un_bv_Smoe    PKR-SSPPPPEHN---L-------LGTG---GFGKV-------------YRGIL-PG-EN
IRAK-Un_ay-2_Smoe  ---------------------------------DTH-------------TQGVI-D---S
IRAK-Un_ay-1_Smoe  ---------------------------------DTH-------------TQGVI-D---S
IRAK-Un_df_Smoe    LRD-IADNFSENN---K-------IGEG---SYGHV-------------YKGTL-HR---
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     -----------SS---L-------LGMG---SFHRS-------------FLPRT-A-E--
IRAK-Un_bb_Smoe    -----------------------------------A-------------MQGVL-KD--G
IRAK-Un_v-1_Smoe   LER-ATKDFSPAQ---M-------LGHG---GHGTV-------------YKGKL-PDG--
IRAK-Un_bx-1_Smoe  LRS-ATGRFSDSH---K-------LGQG---GFGSV-------------FKGTL-KN--G
LRR10a_d-2_Smoe    IAA-ATAGFSRDA---V-------IAMS---RTGVF-------------YKATL-RDG--
IRAK-Un_cz_Smoe    LRI-ATNNFGMEN---R-------L-------RGST-------------FKGIL-SDG--
IRAK-Un_e_Smoe     ---------------------------------------------------GIL-QDG--
IRAK-Un_dn_Smoe    LSV-ATDSFSEEN---Q-------LGQG---GFGVV-------------YKANL-KD--G
IRAK-Un_do_Smoe    IEK-ATNHFHSLI---G-------QGRG---AASAV-------------YRAKF-KDG--
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  LRE-ATNGFSADY---I-------VSESGDKAPNHV-------------YKGRL-DQN--
IRAK-Un_av-1_Smoe  LRE-ATNGFSADY---I-------VSESGDKAPNHV-------------YKGRL-DQN--
IRAK-Un_bx-2_Smoe  LRS-ATGRFSDSH---K-------LGQG---GFGSV-------------FKGTL-KN--G
IRAK-Un_am-1_Smoe  MKR-ATNNFSKER---L-------LGTG---GFGEV-------------YKGTL-DDG--
IRAK-Un_bj-2_Smoe  LEV-ATNYFSDKY---L-------LARK---SSLSI-------------YRAVV-RDG--
IRAK-Un_bj-1_Smoe  LEV-ATNYFSDKY---L-------LARK---SSLSI-------------YRAVV-RDG--
RKF3_a-2_Smoe      IKA-GTQNFSSKN---F-------IGEG---GYGRV-------------YRGVL-AKRGN
IRAK-Un_bo-2_Smoe  LDH-ATKGFNPSN---L-------IGRG---RFGLV-------------YKGLL-EDG--
IRAK-Un_dc_Smoe    LRD-ITDNFSENN---K-------IGEG---SYGHV-------------YKGTL-HR---
IRAK-Un_k-2_Smoe   LSA-ATGNFSISN---K-------IGEG---GYGAV-------------YYGEI-RD--Q
IRAK-Un_bo-1_Smoe  LDH-ATKGFNPSN---L-------IGRG---RFGLV-------------YKGLL-EDG--
IRAK-Un_cb_Smoe    KGDVVAGKYRIVG---V-------LGSG---GVGVT-------------YEAET-EQ--G
IRAK-Un_cs_Smoe    IEL-ITGCFHKVVTRMRVPSSSDGSNDL---IELVV-------------YKGVL-G--RS
IRAK-Un_cu_Smoe    LVR-ATQEFSSSN---F-------IKAG---HSGDL-------------YRGVL-DG--G
IRAK-Un_t_Smoe     LVR-ATQEFSSSN---F-------IKAG---HSGDL-------------YRGVL-DG--G
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  LKI-ATRGFAPEN---K-------LGQG---GFGSV-------------YKGVL-PN--G
IRAK-Un_bp-2_Smoe  LKI-ATRGFAPEN---K-------LGQG---GFGSV-------------YKGVL-PN--G
IRAK-Un_k-1_Smoe   LSA-ATDNFSISK---K-------IGEG---GYGAV-------------YYGEI-RD--Q
IRAK-Un_bd_Smoe    LEQ-ITGGFSK-----C-------LGQG---GYGSV-------------YRGSL-EDG--
IRAK-Un_h_Smoe     FLD-SPESFQQMP---L-------LGAG---GAGKV-------------YKAVL-EG--G
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    LLA-ATKNFHAAN---K-------LGEG---GSAVV-------------YKGII-QT--I
IRAK-Un_ap-1_Smoe  LQE-ATKGFHKDN---L-------VGRG---GFASV-------------YKGVI-D---N
IRAK-Un_ap-2_Smoe  LQE-ATKGFHKDN---L-------VGRG---GFASV-------------YKGVI-D---N


IRAK-Un_aw_Smoe    V-LVAVKKLERSS-----------------FQSRKEFLAEM------------------N
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    H-FVAVKYLTSSD--------------LSD-KARRDFENEV------------------S
IRAK-Un_br-2_Smoe  -----------------------------------AWIEHV------------------K
IRAK-Un_bw_Smoe    S-KVVVKRLEA-A--------------R---QGL---KQFM------------------R
IRAK-Un_ca_Smoe    L-QVRIPRQVD-----------------------LQV-AR--------------------
IRAK-Un_am-2_Smoe  V-VVAIKLAKLGN--------------IK---GRDQVINEV------------------R
IRAK-Un_da_Smoe    T-MVACKYLTNK-----------------D-QAEKEFLVEV------------------E
IRAK-Un_dg_Smoe    M-EVAVKKLKQDV--------------SECSDVEASFRFQM------------------E
IRAK-Un_dj_Smoe    KEAVVIKSVE----------------------SREMFDAEV------------------A
IRAK-Un_dm_Smoe    Q-EVAIKVRSSTS--------------SQ---GLREFTAEL------------------T
IRAK-Un_ag_Smoe    L-HVALKEVHDGK--------------S-SS---REL-AAL------------------Q
IRAK-Un_dq_Smoe    L-HVALKEVHDGK--------------S-SS---REL-AAL------------------Q
IRAK-Un_dh_Smoe    N-QVAVKKLQGS---------------NQ---TSRDFYAEL------------------A
IRAK-Un_dp_Smoe    D-VVAVKLLHRSP--------------QQ---ASPQFMAEI------------------D
IRAK-Un_bk-2_Smoe  L-LVVVKRVDVTS----------------L--KKDFLLSEL------------------E
IRAK-Un_bk-1_Smoe  L-LVVVKRVDVTS----------------L--KKDFLLSEL------------------E
IRAK-Un_ck_Smoe    --KLAVKRMN-------------------M-QATKEFLSEL------------------K
IRAK-Un_cn_Smoe    R-VVVIKKKVS--------------------------ELEL------------------D
IRAK-Un_bg_Smoe    R-TVAIKQASAKS-----------------KQGQREFRNEI------------------Q
IRAK-Un_cj_Smoe    --KLAVKRMN-------------------M-QATKEFLSEL------------------K
IRAK-Un_v-2_Smoe   R-DVAVKRINHIS--------------SH---GIEQVLNEV------------------K
IRAK-Un_de_Smoe    T-RLAVKVLSST----------------SK-QGEREFQTEV------------------S
IRAK-Un_dk_Smoe    S-HLAVKRLRNE----------------NV-ANDPSFEAEI------------------S
IRAK-Un_bv_Smoe    S-PVAIKKMVRD----------------SH-QGEREFLAEL------------------Q
IRAK-Un_ay-2_Smoe  H-VVAVKYLTSSD--------------LSE-KARLDFENEV------------------S
IRAK-Un_ay-1_Smoe  H-VVAVKYLTSSD--------------LSE-KARLDFENEV------------------S
IRAK-Un_df_Smoe    T-NVAVKVLRHDS--------------WQ---GPQEFEQEVRKLTRISKISNEHGKIKVE
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     K-PLALKK----S--------------RA---GDKSLVKEL------------------S
IRAK-Un_bb_Smoe    S-EVAVKQLDLHS----------------K-QGQREFVNEL------------------S
IRAK-Un_v-1_Smoe   R-DVAVKRINHIS--------------SH---GIEQVLNEV------------------K
IRAK-Un_bx-1_Smoe  Q-HIAVKKLDTA----------------SL-QGEREFMNEL------------------S
LRR10a_d-2_Smoe    S-VLAVKKLRRAA--------------MH-SAGEKHFRSEM------------------E
IRAK-Un_cz_Smoe    V-LVAVKKLERSS-----------------FQSRKEFLAEM------------------N
IRAK-Un_e_Smoe     T-VVAIKRSKSSA--------------NFG-VMDEQFLNEI------------------T
IRAK-Un_dn_Smoe    T-QVAVKKLSLHS----------------K-QGKQEFVNEL------------------N
IRAK-Un_do_Smoe    L-VAAVKRFHAAP--------------Q-P-QSEEEFKNEA------------------H
IRAK-Un_br-1_Smoe  ----------------------------------------V------------------K
IRAK-Un_av-2_Smoe  R-WIAVKKFPKTA-----------------WPDARQFMDEA------------------F
IRAK-Un_av-1_Smoe  R-WIAVKKFPKTA-----------------WPDARQFMDEA------------------F
IRAK-Un_bx-2_Smoe  Q-HIAVKKLDTA----------------SL-QGEREFMNEL------------------S
IRAK-Un_am-1_Smoe  V-VVAIKLAKLGN--------------IK---GRDQVINEV------------------R
IRAK-Un_bj-2_Smoe  S-TAVIKYFTKTR--------------F-V-GGEEEFEAAL------------------S
IRAK-Un_bj-1_Smoe  S-TAVIKYFTKTR--------------F-V-GGEEEFEAAL------------------S
RKF3_a-2_Smoe      S-EVAVKVMKASS----------------K-ENNAEFLNEV------------------E
IRAK-Un_bo-2_Smoe  T-IVAIKTRAS--------------------APTQEFVTEV------------------V
IRAK-Un_dc_Smoe    T-NVAVKVLRHDS--------------WQ---GPQEFEQEVRKLTRISKISNKHGKIKVE
IRAK-Un_k-2_Smoe   --KLAIKKMN-------------------M-QATREFMSEL------------------K
IRAK-Un_bo-1_Smoe  T-IVAIKTRAS--------------------APTQEFVTEV------------------V
IRAK-Un_cb_Smoe    D-AVAIKAMSLRN--------------MKGWKDLDLFEREA------------------R
IRAK-Un_cs_Smoe    --EVLV-----------------------E-CGKGDFKDRM------------------T
IRAK-Un_cu_Smoe    V-LVVVKRIEVAK----------------M--KKDLLTLEL------------------E
IRAK-Un_t_Smoe     V-LVVVKRIEVAK----------------M--KKDLLTLEL------------------E
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  T-IVAMKELSSKS----------------N-QGTREFLNEV------------------T
IRAK-Un_bp-2_Smoe  T-IVAMKELSSKS----------------N-QGTREFLNEV------------------T
IRAK-Un_k-1_Smoe   --KLAIKKMN-------------------M-QATREFMSEL------------------K
IRAK-Un_bd_Smoe    N-QVAVKKLQGS---------------NQ---NSRDFYAEV------------------A
IRAK-Un_h_Smoe     M-EVAVKRIPIQPPEPPSSSDASRSSGKGS-FGKRHTVAEM------------------E
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    G-PVAIKFLQIKA--------------H-S-ISNEEFINEV------------------S
IRAK-Un_ap-1_Smoe  H-FVAVKYLTSSD--------------LSD-KARRDFENEV------------------S
IRAK-Un_ap-2_Smoe  H-FVAVKYLTSSD--------------LSD-KARRDFENEV------------------S


IRAK-Un_aw_Smoe    RIARLR-HP----SLV-------------------AVIGCCYDH----------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    TICLLQ-HK----NVV-------------------KLFGFCSEK----------------
IRAK-Un_br-2_Smoe  EIVCLR-DA----HLS-------------------RILGFSFTT----------------
IRAK-Un_bw_Smoe    TIGSVR-HQ----NLV-------------------KLQGYGAH-----------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  VLSQVN-HR----NLV-------------------RIWGCCVDTG---------------
IRAK-Un_da_Smoe    TIGRVR-HK----NLV-------------------KLLGFCAEG----------------
IRAK-Un_dg_Smoe    LLSRVH-HQ----HLA-------------------NLVGICDEK----------------
IRAK-Un_dj_Smoe    MLAGLG-HSSSANRFV-------------------QIIGICSSSSAGGGGGGGGDCADGH
IRAK-Un_dm_Smoe    LLSKIR-HP----NLV-------------------PLLGYCTEGQ---------------
IRAK-Un_ag_Smoe    LLTNS---S----HVV-------------------QLLDHVW-----------------L
IRAK-Un_dq_Smoe    LLTNS---S----HVV-------------------QLLDHVW-----------------L
IRAK-Un_dh_Smoe    SLARTN-HL----NLV-------------------KFIGFCAEGP---------------
IRAK-Un_dp_Smoe    ILSRFK-HP----NLV-------------------QLLGCSTDG----------------
IRAK-Un_bk-2_Smoe  FFSKAS-HT----RLV-------------------PLLGHCLER----------------
IRAK-Un_bk-1_Smoe  FFSKAS-HT----RLV-------------------PLLGHCLER----------------
IRAK-Un_ck_Smoe    ILSRVH-HS----NLVFSQALYFQLTPTIIFLLQVQLIGYCTV-----------------
IRAK-Un_cn_Smoe    ILLRIR-SA----SIV-------------------NLVGFSSD-----------------
IRAK-Un_bg_Smoe    LLSRLH-HR----HLV-------------------RLLGFCQSG----------------
IRAK-Un_cj_Smoe    ILSRVH-HS----NLVFSQALYFQLTPTIIFLLQVQLIGYCTV-----------------
IRAK-Un_v-2_Smoe   VLLSVS-HP----NLV-------------------QLLGCCLEVY---------------
IRAK-Un_de_Smoe    LLGRLH-HK----NLV-------------------NLVGYCTDR----------------
IRAK-Un_dk_Smoe    TLGLIK-HR----NLV-------------------SLKGFYCSA----------------
IRAK-Un_bv_Smoe    IISKRS-HR----NLV-------------------PLRGWHCARD---------------
IRAK-Un_ay-2_Smoe  TICLLQ-HK----NVV-------------------RLFGFCSEK----------------
IRAK-Un_ay-1_Smoe  TISLLQ-HK----NVV-------------------KLFGFCSEK----------------
IRAK-Un_df_Smoe    VLSRLH-HP----HIV-------------------LLLGGNPE-----------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     LLARLH-HA----YLV-------------------NLVGYCAQ-----------------
IRAK-Un_bb_Smoe    IITSIQ-HK----NLA-------------------KLRGYCLDR----------------
IRAK-Un_v-1_Smoe   VLLSVS-HP----NLV-------------------QLLGCCLEVY---------------
IRAK-Un_bx-1_Smoe  IMGSMASSP----FVV-------------------GLIGFCAET----------------
LRR10a_d-2_Smoe    ALAKVR-HR----NLV-------------------PLLGYCIAG----------------
IRAK-Un_cz_Smoe    RIARLR-HP----SLV-------------------AVIGCCYDH----------------
IRAK-Un_e_Smoe     ILSQVN-HR----NLV-------------------KLKGWCMDTR---------------
IRAK-Un_dn_Smoe    IITGIR-HR----NLA-------------------MLHGYCVEA----------------
IRAK-Un_do_Smoe    FLGRLH-HR----HLV-------------------SLRGFCMRKN---------------
IRAK-Un_br-1_Smoe  EIVCLR-DA----HLS-------------------RILGFSFTT----------------
IRAK-Un_av-2_Smoe  GVGQVR-HE----RLV-------------------NLIGCCCEG----------------
IRAK-Un_av-1_Smoe  GVGQVR-HE----RLV-------------------NLIGCCCEG----------------
IRAK-Un_bx-2_Smoe  IMGSMASSP----FVV-------------------GLIGFCADS----------------
IRAK-Un_am-1_Smoe  VLSQVN-HR----NLV-------------------RIWGCCVDTG---------------
IRAK-Un_bj-2_Smoe  SFVQLK-HD----NLV-------------------KLKGFCCVQ----------------
IRAK-Un_bj-1_Smoe  SFVQLK-HD----NLV-------------------KLKGFCCVQ----------------
RKF3_a-2_Smoe      VINRVR-HR----NLL-------------------SVRGACVHAN-------------GP
IRAK-Un_bo-2_Smoe  NLSQLR-HK----NVV-------------------SLLGFCQE-----------------
IRAK-Un_dc_Smoe    VLSRLH-HP----HIV-------------------LLLGGNPE-----------------
IRAK-Un_k-2_Smoe   VLTHVH-HT----NLV-------------------QLIGYCTV-----------------
IRAK-Un_bo-1_Smoe  NLSQLR-HK----NVV-------------------SLLGFCQE-----------------
IRAK-Un_cb_Smoe    VLKSLQ-HS----GIP-------------------EYIDFFEIEN--------------E
IRAK-Un_cs_Smoe    ALW-SP-HP----NIV-------------------RLLGFCTSP----------------
IRAK-Un_cu_Smoe    VFGKAS-HT----RLV-------------------PLLGHCLEM----------------
IRAK-Un_t_Smoe     VFGKAS-HT----RLV-------------------PLLGHCLEM----------------
IRAK-Un_dd_Smoe    --------------------------------------GG-CQ-----------------
IRAK-Un_bp-1_Smoe  VISAVQ-HR----NLV-------------------KLHGCCIEG----------------
IRAK-Un_bp-2_Smoe  VISAVQ-HR----NLV-------------------KLHGCCIEG----------------
IRAK-Un_k-1_Smoe   VLTHVH-HT----NLV-------------------QLIGYCTV-----------------
IRAK-Un_bd_Smoe    SLARTN-HL----NLV-------------------KFIGFCAEGP---------------
IRAK-Un_h_Smoe     TLGKIR-HV----NLA-------------------WLYAYILKP----------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    TISYLQ-HK----NLI-------------------RLVGFCCEG----------------
IRAK-Un_ap-1_Smoe  AICLLQ-HK----NVV-------------------KLFGFCSEK----------------
IRAK-Un_ap-2_Smoe  TICLLQ-HK----NVV-------------------KLFGFCSEK----------------


IRAK-Un_aw_Smoe    --GERYIAYEYIANGP-LDLWLHDPV----------------------RRGTLD-WRTRM
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    --EHKLIVCEFIENGN-LSEALFSSPD---------------------KGLELN-WTARY
IRAK-Un_br-2_Smoe  --DEKLVVYEIQANGS-LDRLLYGRSR---------------------DRPPLD-WATRV
IRAK-Un_bw_Smoe    G-QHYYRVCG--ISGS-LLR---SMK-----------------------QQALR-WERRW
IRAK-Un_ca_Smoe    -------------------------------------------------RA---QLGHEI
IRAK-Un_am-2_Smoe  ---EPLVVYEYIPNGT-LYEWLHV---------------------G---RGFLD-WRSRL
IRAK-Un_da_Smoe    --DHRILVYEYVNNGN-LDEWLHGKTS---------------------RFKTPS-WDSRM
IRAK-Un_dg_Smoe    --QERMLLFQYAPNGT-LFENLHTG------------------------DENLS-WKQRM
IRAK-Un_dj_Smoe    A-QRMLLVLRQMPNGD-LASALRRGDEFK---SSDGETSESSDSSSAGSAKPLD-WITRF
IRAK-Un_dm_Smoe    ---HEMLVYPYMSNGT-LQDRLYG---------------------EAATRKPLD-WQTRL
IRAK-Un_ag_Smoe    H-PGVLLVLEFL-PGS-LAEVIEERK-----------------------EIPFQEFEAR-
IRAK-Un_dq_Smoe    H-PGVLLVLEFL-PGS-LAEVIEERK-----------------------EIPFQEFEAR-
IRAK-Un_dh_Smoe    --RKRLLVYEFVANGS-LEKWIFVDGGGDDDSS----------SQQQDGSGGLS-WDFKF
IRAK-Un_dp_Smoe    --QSLLLVYEFVGNGT-LADHLHT------------------------KKSRLP-WLTRL
IRAK-Un_bk-2_Smoe  E-NEKFLVYKYMQHGD-LARALHRKIVPS---------------PPKDILQSLD-WITRL
IRAK-Un_bk-1_Smoe  E-NEKFLVYKYMQHGD-LARALHRKIVPS---------------PPKDILQSLD-WITRL
IRAK-Un_ck_Smoe    --ESLFLVYEFVDNGT-LAQHLHSTT-----------------------RPPLS-WSSRI
IRAK-Un_cn_Smoe    A-QQKCLVFDYMHLGR-LSRRLFDDT-----------------------LPPIS-WGNRL
IRAK-Un_bg_Smoe    --KNQV------------------------------------------------------
IRAK-Un_cj_Smoe    --ESLFLVYEFVDNGT-LAQHLHSAT-----------------------RPPLS-WSSRI
IRAK-Un_v-2_Smoe   ---DPLLVYEFVPNGT-LAEHLQR---------------------E-R-GDGLD-WFTRV
IRAK-Un_de_Smoe    --RERMLVYEYMSNGS-LEKLLYND---------------------K--REALS-WSERV
IRAK-Un_dk_Smoe    --QEKLLFYDYMPCGS-LHDVLHGGGVA-----------------SASPSTLLS-WMARL
IRAK-Un_bv_Smoe    H-RELVLVYDYMPQGS-VESALFHK---------------------G-DALLLL-WDARL
IRAK-Un_ay-2_Smoe  --EHKLIVCELVENGN-LSDALFELLTRV---S----------SISVRNDLQLD-WTARY
IRAK-Un_ay-1_Smoe  --EHKLIVCELVENGN-LSDALFEIMKRV---S----------SISVWKDLQLD-WTARY
IRAK-Un_df_Smoe    ---KKCLVYEYLENGS-LEDRLFC---------------------KD-DSPPIS-CLTRY
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ---EQLLAFEFMENGS-LFDCLFK---------------------KP--EIRLD-WFLRI
IRAK-Un_bb_Smoe    --DDRILVYEFLENKS-LDQLLFESAT----------------------GIFLD-WPTRF
IRAK-Un_v-1_Smoe   ---DPLLVYEFVPNGT-LAEHLQR---------------------E-R-GDGLD-WFTRV
IRAK-Un_bx-1_Smoe  --KRKMLVYEFMANRS-LQEVLFDE---------------------K-HSVVLQ-WERRA
LRR10a_d-2_Smoe    --NERLLVYKHMPCGN-LYNRLHTAAAST---P--------GDSSSGSTSGRLD-WAARL
IRAK-Un_cz_Smoe    --GERYIAYEYIANGP-LDLWLHDPV----------------------RRGTLD-WRTRM
IRAK-Un_e_Smoe     RNAPPLLVYEYVTNGT-LLEHLQC---------------------K-RGVVPLG-WEQRL
IRAK-Un_dn_Smoe    --NERLLVYEFLENGS-LDSALFQSS------------------------SALN-WQSRF
IRAK-Un_do_Smoe    ---ERFLVYDFMENGS-LKERLHLHH-------------------RGRSNGTLS-WQRRL
IRAK-Un_br-1_Smoe  --DEKLVVYEIQANGS-LDRLLYGRSR---------------------DRPPLD-WATRV
IRAK-Un_av-2_Smoe  --DERLLVAEYMPNDT-LTKHLFHWE-----------------------KQPMQ-WSMRL
IRAK-Un_av-1_Smoe  --DERLLVAEYMPNDT-LTKHLFHWE-----------------------KQPMQ-WSMRL
IRAK-Un_bx-2_Smoe  --KRKMLVYEFMANRS-LQEILFDE---------------------K-HSVVLQ-WERRA
IRAK-Un_am-1_Smoe  ---EPLVVYEYIPNGT-LYEWLHV---------------------G---RGFLD-WRSRL
IRAK-Un_bj-2_Smoe  GGLQCYLVYDFVPNGS-LFEHLHGPS-----------------------VSPLD-WGTRV
IRAK-Un_bj-1_Smoe  GGLQCYLVYDFVPNGS-LFEHLHGPS-----------------------VSPLD-WGTRV
RKF3_a-2_Smoe      D-SQHILVYDYMPNGC-LKTYLSS--------------------------GTLS-WQQRR
IRAK-Un_bo-2_Smoe  H-DHQMLVYDYLPNGS-VSSHLCDPNG--------------------NPTGELD-FKQRV
IRAK-Un_dc_Smoe    ---KKCLVYEYLENGS-LEDRLFC---------------------KD-DSPPIS-CLTRY
IRAK-Un_k-2_Smoe   --DSLFLVYEYVDNGT-LSHHLRGSA-----------------------PSRLT-WNQRI
IRAK-Un_bo-1_Smoe  H-DHQMLVYDYLPNGS-VSSHLCDPNG--------------------NPTGELD-FKQRV
IRAK-Un_cb_Smoe    K-DKGFYIVQKVAKGKSLAKLV-EEG-----------------------W-RVS-EQEVK
IRAK-Un_cs_Smoe    --FLHALVMPLEKRGC-LKGMVLD--------------------------GSLG-WKQRV
IRAK-Un_cu_Smoe    D-ELKFLVYKYMPNGD-LGQALHKKVVPS---------------PPADILQSLD-WITRL
IRAK-Un_t_Smoe     D-ELKFLVYKYMPNGD-LGQALHKKVVPS---------------PPADILQSLD-WITRL
IRAK-Un_dd_Smoe    ------------------SDVISS------------------------------------
IRAK-Un_bp-1_Smoe  --SHRILIYEFLENNS-LHQALLKPKE---------------------RVIHFD-WPTRF
IRAK-Un_bp-2_Smoe  --SHRILIYEFLENNS-LHQALLKPKE---------------------RVIHFD-WPTRF
IRAK-Un_k-1_Smoe   --DSLFLVYEYVDNGT-LSHHLRGSA-----------------------PSRLT-WNQRI
IRAK-Un_bd_Smoe    --RKRLLVYEFVPNGS-LEKWIFGDDGGDD-SS----------SQQQDGSGGLS-WDCKF
IRAK-Un_h_Smoe     --DAHLLLYQYMPRGS-LQDVLARV---------------------RDGAMELE-WSARQ
IRAK_Un_dd_Smoe    ---------EFVPNGT-LAEHLQR---------------------E-R-GDGLD-WFTRV
IRAK-Un_bf_Smoe    --EHRLLVYEFLENNS-LALAILSGPN----------------------KLYIP-WAKRY
IRAK-Un_ap-1_Smoe  --EHKLIVCEFIENGN-LSDALFRSPD---------------------KGLELN-WTARY
IRAK-Un_ap-2_Smoe  --EHKLTVCEFIENGN-LSDALFRSPD---------------------KGLELN-WTARY


IRAK-Un_aw_Smoe    QIAVTAAQGIAYLHDQV---KPHVIHRDIKASSILLDDKF--------------------
IRAK-Un_co_Smoe    --------------FAA---SPPIYHRDVKSSNILLDEKL--------------------
IRAK-Un_ax_Smoe    NICVGVAQGLAYLHGETS--QATIVHRDIKALNILLASNL--------------------
IRAK-Un_br-2_Smoe  RIATDAARGLAFLHERS---PTKLMYKDFRTFNVHVDKEL--------------------
IRAK-Un_bw_Smoe    RIAADIARGLDYLHGGC---KDQVLHLDIKPQNILLDASF--------------------
IRAK-Un_ca_Smoe    QDSREIARGICFLHEEC---STRVLHLAINPQNTLLAENF--------------------
IRAK-Un_am-2_Smoe  RIALQTAEGLAYLHSAA---YPPIYHRDVKSSNILLDNSL--------------------
IRAK-Un_da_Smoe    KIILGTAKGLAYMHEAI---EPKIVHRDIKASNILLDSHW--------------------
IRAK-Un_dg_Smoe    RIIVGAAYGLAYLHHLC---NPPVIHGDLRSRNILLTEDF--------------------
IRAK-Un_dj_Smoe    KIAIGVAEALAFLHHDC---SPAVIHRDLKSSSVFLDEGY--------------------
IRAK-Un_dm_Smoe    SIAIGAARGLNFLHTSG---PRPIIHRDVKSSNILLDDSM--------------------
IRAK-Un_ag_Smoe    NWMEQILKAVAECH------SAGILHRDLKPSNLLISSDG--------------------
IRAK-Un_dq_Smoe    NWMEQILKAVAECH------SAGILHRDLKPSNLLISSDG--------------------
IRAK-Un_dh_Smoe    RIAVGTAQGLCYLHEEC---AEKIIHLDLKPENVLVDIGF--------------------
IRAK-Un_dp_Smoe    AIAIDIAQVLAYLHSY------SILHRDVKSTNVLLDEGF--------------------
IRAK-Un_bk-2_Smoe  KIAIGAAEGLSYLHHEC---SPALVHRDIKATSILLDDKF--------------------
IRAK-Un_bk-1_Smoe  KIAIGAAEGLSYLHHEC---SPALVHRDIKATSILLDDKF--------------------
IRAK-Un_ck_Smoe    QIAMDAARGLEYIHEHA---KPTYIHRDIKSTNILIDKNF--------------------
IRAK-Un_cn_Smoe    RIALQISRAVEYLHTYA---EPHIVHLNISAENVLLDGSW--------------------
IRAK-Un_bg_Smoe    --------------------------RRILASRQFIGMCL--------------------
IRAK-Un_cj_Smoe    QIAMDAARGLEYIHEHT---KPTYIHRDIKSTNILIDKNL--------------------
IRAK-Un_v-2_Smoe   AIAAEAAQGIAYLHSRS----PPIYHRDVKSTNILLDGEF--------------------
IRAK-Un_de_Smoe    QIAKDVSRGIEYLHDGA---VPPVIHRDIKSANILLDNSM--------------------
IRAK-Un_dk_Smoe    RIAVGTARGLLYLHEGC---SPRIIHRDVKSSNILLDSDM--------------------
IRAK-Un_bv_Smoe    RILSGLAAALIYLHEDW---EQQVIHRDVKCSNVMLDEEF--------------------
IRAK-Un_ay-2_Smoe  NICVGVAQGLAYLHGETS--QVTIVHRDIKALNILLASDL--------------------
IRAK-Un_ay-1_Smoe  NICVGVAQGLAYLHGETS--QATIVHRDIKALNILLASDL--------------------
IRAK-Un_df_Smoe    QIAVEVGTALLFLHKAK---PQPIVLRDLKPSNILLDKNY--------------------
IRAK-Un_bt_Smoe    -------RGLKYLHEIV---SPLIIHRDFKSSNILLADKF--------------------
IRAK-Un_r_Smoe     RIAAQAARGLEYLHIYA---SPQILHRDVKAANILLDKDW--------------------
IRAK-Un_bb_Smoe    QIVLGVANGLAYLHEGS---QKQIIHRDIKASNILLDHKL--------------------
IRAK-Un_v-1_Smoe   AIAAEAAQGIAYLHSRS----PPIYHRDVKSTNILLDGEF--------------------
IRAK-Un_bx-1_Smoe  KIVADVARALAFLHGKC---EPPIVHGDVKPSNVLLGADF--------------------
LRR10a_d-2_Smoe    KVAVGTARGLAWLHHSC---NPRLVHKGITSASILLDEDL--------------------
IRAK-Un_cz_Smoe    QIAVTAAQGIAYLHDQV---KPHVIHRDIKASSILLDDKF--------------------
IRAK-Un_e_Smoe     QIVIETAEALAYLHSVA---APPIYHRDVKSSNILLDDSL--------------------
IRAK-Un_dn_Smoe    QITIGIARGLAYLHEES---HFQIIHRDIKASNVLLDAKL--------------------
IRAK-Un_do_Smoe    QIAIEVATGMEYVHCYC---EPPLCHGNLKSSNILLDENF--------------------
IRAK-Un_br-1_Smoe  RIATDAARGLAFLHERS---PTKLMYKDFRTFNVHVDKEL--------------------
IRAK-Un_av-2_Smoe  RVALYIAQALEHCSN-----NNRRLYHDLNAYRVLFDQVLFNPFRSLLVYALTAAVLQDG
IRAK-Un_av-1_Smoe  RVALYIAQALEHCSN-----NNRRLYHDLNAYRVLFDQVLFNPFRSLLVYALTAAVLQDG
IRAK-Un_bx-2_Smoe  KIVADVARALAFLHGKC---EPPIVHGDVKPSNVLLGADF--------------------
IRAK-Un_am-1_Smoe  RIALQTAEGLAYLHSAA---YPPIYHRDVKSSNILLDNSL--------------------
IRAK-Un_bj-2_Smoe  QIAHGVAKGLDYLHRNG---EQ-VI---VWASNVLLDESY--------------------
IRAK-Un_bj-1_Smoe  QIAHGVAKGLDYLHRNG---EQ-VI---VWASNVLLDESY--------------------
RKF3_a-2_Smoe      KIAIGIAVGINYLHNEV---EPSIIHRDIKPSNILLDEDL--------------------
IRAK-Un_bo-2_Smoe  AIALGAARGLEYLHSGN---PP-RVHQDFKTSNVLLDENL--------------------
IRAK-Un_dc_Smoe    QIAVEVGTALLFLHKAK---PQPIVLRDLKPSNILLDKNY--------------------
IRAK-Un_k-2_Smoe   QIALDAARGLEYIHEHT---KPTYIHRDVKSPNILIDKRL--------------------
IRAK-Un_bo-1_Smoe  AIALGAARGLEYLHSGN---PP-RVHQDFKTSNVLLDENL--------------------
IRAK-Un_cb_Smoe    DIAIEILDVLKYLGS-L---RPPVIHRDIKPDNIILDEATG-------------------
IRAK-Un_cs_Smoe    KIIKGLALALDHLHDARNVLGFQVLHLGVRLENVWVAEDY--------------------
IRAK-Un_cu_Smoe    KIAIGVAEGLSYLHHEC---VPPLVHRDVQASSILLDDKF--------------------
IRAK-Un_t_Smoe     KIAIGVAEGLSYLHHEC---VPPLVHRDVQASSILLDDKF--------------------
IRAK-Un_dd_Smoe    -------------RGSQ---VGTIIRRDLRPHNILLTHDY--------------------
IRAK-Un_bp-1_Smoe  NICVGIARGIAYLHEES---LPRIVHRDIKASNVLLDKTL--------------------
IRAK-Un_bp-2_Smoe  NICVGIARGIAYLHEES---LPRIVHRDIKASNVLLDKTL--------------------
IRAK-Un_k-1_Smoe   QIALDAARGLEYIHEHT---KPTYIHRDVKSPNILIDKRL--------------------
IRAK-Un_bd_Smoe    RIAVGTAQGLCYLHEEC---ADRIIHLDLKPENVLVDIGF--------------------
IRAK-Un_h_Smoe     RIATGMVRGLKYLHYDC---SPKILHRDLKTSNILLDEEL--------------------
IRAK_Un_dd_Smoe    AIAADAAQGIAYLHSRS----PPIYHRDVKSTNILLDDES--------------------
IRAK-Un_bf_Smoe    EICLGVARGIAYLHEES---RTRIVHRDIKASNILLDKEF--------------------
IRAK-Un_ap-1_Smoe  NICVGVAQGLAYLHGETS--QATIVHRDIKALNILLASNL--------------------
IRAK-Un_ap-2_Smoe  NICVGVAQGLAYLHGETS--QATIVHRDIKALSILLASNL--------------------
                                               .      .

IRAK-Un_aw_Smoe    HGRVMGVGLASVVPWEAA---YE-------------------------------------
IRAK-Un_co_Smoe    TANVADFGISKVVPIDS---TRIS------------------------------------
IRAK-Un_ax_Smoe    EAKISDFGLARLIQEDR---SYIS------------------------------------
IRAK-Un_br-2_Smoe  RARLMGYGFTQSLEEKIL--TRC-------------------------------------
IRAK-Un_bw_Smoe    GAKICDFGLERVDHEK----NSVS------------------------------------
IRAK-Un_ca_Smoe    GVKIADVGLSRWRM----------------------------------------------
IRAK-Un_am-2_Smoe  VARVCDFGLSRLAEPDL---SHVS------------------------------------
IRAK-Un_da_Smoe    NAKVSDFGLAKFLGCEK---THVM------------------------------------
IRAK-Un_dg_Smoe    AAKVWAMVVPIAGSSEL---ALVRK-----------------------------------
IRAK-Un_dj_Smoe    EVRLGSFGKACRQQYG--------------------------------------------
IRAK-Un_dm_Smoe    NARVADFGFSRFAPQEDD--SLVS------------------------------------
IRAK-Un_ag_Smoe    VLKVADFGTALVLPVEN---VEEALK----------------------------------
IRAK-Un_dq_Smoe    VLKVADFGTALVLPVEN---VEEAVKD--------SSSGK--------------------
IRAK-Un_dh_Smoe    VPKIADFGLSKLMNREVT---YLQ------------------------------------
IRAK-Un_dp_Smoe    HAKLGDFGLSKAAAAAAAVEGHV-------------------------------------
IRAK-Un_bk-2_Smoe  EVRLGSLSEARIQDGGVHP--NLI------------------------------------
IRAK-Un_bk-1_Smoe  EVRLGSLSEARIQDGGVHP--NLI------------------------------------
IRAK-Un_ck_Smoe    HAKVADFGLSKLTETGM---TSIS------------------------------------
IRAK-Un_cn_Smoe    NAKLSGFGRAQSSSVA----IKPA------------------------------------
IRAK-Un_bg_Smoe    KDYL--------------------------------------------------------
IRAK-Un_cj_Smoe    HAKVADFGLSKLTETGM---TSIS------------------------------------
IRAK-Un_v-2_Smoe   NTKVGDFGLSRTALTEA---SHVS------------------------------------
IRAK-Un_de_Smoe    TARVADFGLSKEVSPVV-------------------------------------------
IRAK-Un_dk_Smoe    EPHIADFGLARLVENNA---TH--------------------------------------
IRAK-Un_bv_Smoe    RARLGDFGLARTASHDV---SS--------------------------------------
IRAK-Un_ay-2_Smoe  KPKISDFGLARLIQQSR---SYIS------------------------------------
IRAK-Un_ay-1_Smoe  KPKISDFGLARLIQQSR---SYTS------------------------------------
IRAK-Un_df_Smoe    NSKISDVGLARFMPGDET--SVRS------------------------------------
IRAK-Un_bt_Smoe    NTKVSDFGLAKLGLDKA-------------------------------------------
IRAK-Un_r_Smoe     NAHLSDFGFSLSPS-GNT--TQLA------------------------------------
IRAK-Un_bb_Smoe    HPKISDFEISKLFNQEK---GFTS------------------------------------
IRAK-Un_v-1_Smoe   NTKVGDFGLSRTALTEA---SHVS------------------------------------
IRAK-Un_bx-1_Smoe  GAKLADFGLARVKTQES---AAVDERERNDDFGKLSRGGAATPSSIGGGQDDDEEWSKLS
LRR10a_d-2_Smoe    EPRITDFGLARLIVTGR---GRPGGA----------------------------------
IRAK-Un_cz_Smoe    HGRVMGVGLASVVPWEAA---YE-------------------------------------
IRAK-Un_e_Smoe     SAKVADFGISKLVGTGDAATTHVS------------------------------------
IRAK-Un_dn_Smoe    QPKISDFGLSKLFDLDG---KHVV------------------------------------
IRAK-Un_do_Smoe    VAKVSKDGDTVFLFLV-FFISTSS------------------------------------
IRAK-Un_br-1_Smoe  RARLMGYGFTQRFMNPSS--LMVRSK----------------------------------
IRAK-Un_av-2_Smoe  DPRLSCFGLMKNSRDGKS---Y--------------------------------------
IRAK-Un_av-1_Smoe  DPRLSCFGLMKNSRDGKS---Y--------------------------------------
IRAK-Un_bx-2_Smoe  GAKLADFGLARVKTQES---AAVDERERNDDFGKVSRGGAATPSSIGGGQDDDEEWSKLS
IRAK-Un_am-1_Smoe  VARVCDFGLSRLAEPDL---SHVS------------------------------------
IRAK-Un_bj-2_Smoe  NALVSSWGHNKVLADEL---VYAN------------------------------------
IRAK-Un_bj-1_Smoe  NALVSSWGHNKVLADEL---VYAN------------------------------------
RKF3_a-2_Smoe      NARVADFGLAKISPEGMS---HLT------------------------------------
IRAK-Un_bo-2_Smoe  VAKVTDVGLSKLLVTSH---NAMP------------------------------------
IRAK-Un_dc_Smoe    NSKISDVGLARFMPGDAT--SVRS------------------------------------
IRAK-Un_k-2_Smoe   RAKVADFGLTKLTESGA---GSVS------------------------------------
IRAK-Un_bo-1_Smoe  VAKVTDVGLSKLLVTSH---NAMP------------------------------------
IRAK-Un_cb_Smoe    KVKVVDFGAVQDTTSSA---TF--------------------------------------
IRAK-Un_cs_Smoe    TPKLAGFYSCKIRRSRK---SIS-------------------------------------
IRAK-Un_cu_Smoe    EVRLGSLSETREQGGEAQP--GLI------------------------------------
IRAK-Un_t_Smoe     EVRLGSLSETREQGGEAQP--GLI------------------------------------
IRAK-Un_dd_Smoe    APMVGDFGLARWHTSSQ---PA--------------------------------------
IRAK-Un_bp-1_Smoe  NPKIADFGLAKLFKDHQ---THVS------------------------------------
IRAK-Un_bp-2_Smoe  NPKIADFGLAKLFKDHQ---THVS------------------------------------
IRAK-Un_k-1_Smoe   RAKVADFGLTKLTESGA---GSVS------------------------------------
IRAK-Un_bd_Smoe    VPKIADFGLSKLMNREVT---YLQ------------------------------------
IRAK-Un_h_Smoe     EAHLGDFGLAKALPDGM---TH--------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    NARVSDFGLARLLKDGD---THLS------------------------------------
IRAK-Un_ap-1_Smoe  EAKISDFGLARLIQEDR---SYIS------------------------------------
IRAK-Un_ap-2_Smoe  EAKISDFGLARLIQEDR---SYIN------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  QSAYGTEADTWSKISPSEIDCRSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGN
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  QSAYGTEADTWSKISPSEIDCRSEISFDGTGQGQAGIKNFLGRKKPWGQRKASASPSSGN
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ---------------------------------------------------KKLKGGAEF
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  GKNSNNGSRDWWWKQESSGQQGGGGGEFSIREYIVDWVSCENRRGRSRTREWPWNAASS-
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  GKNTNNGSRDWWWKQESSGQQGGGGGEFSIREYIVDWVSCENRRGRSRTREWPWNAASS-
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    --------------------------SAATS-----------------------------
IRAK-Un_dq_Smoe    DRFGSGKKLDSEEIEAWLQGGSFKLKSAATS-----------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  --------------------GTAGAAAAGTSSEGKNNVKKKKKQARSGSLEWWAECDDDD
LRR10a_d-2_Smoe    --------------------------G-G-------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  --------------------------VLA-------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  --------------------GTAGAAAAGTSSEGKNNVKKKKKQARSGSLEWWAECDDDD
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGELTSNETNNNNRKGGRLFETWSRESLSG
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ELAKRIKAEQKRKKNREWWSGEMQRGKEWWSGELTSNETNN-NRKGGRLFETWSRESLSG
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    SEQQPETMVPAQIRGSKSYDRLEIE-----DSGTEVSPRVSDAEEEEDGARSRNDRYSDG
IRAK-Un_dq_Smoe    SEQQPETMVPAQIRGSKSYDRLEIE-----DSGTEVSPRVSDAE----------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ELTR-----RRRRERSRSHS----RDWWSGDLVSR-------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ---------------------------------ER-------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ELTR-----RRRRERSRSHS----RDWWSGDLVSR-------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    --------------------------------------------------------RTVV
IRAK-Un_co_Smoe    --------------------------------------------------------T-TL
IRAK-Un_ax_Smoe    ---------------------------------------------------------TRA
IRAK-Un_br-2_Smoe  --------------------------------------------------------CSLC
IRAK-Un_bw_Smoe    ---------------------------------------------------------TVM
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  --------------------------------------------------------T-CA
IRAK-Un_da_Smoe    ---------------------------------------------------------TRV
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    --------------------------------------------------------V-EV
IRAK-Un_ag_Smoe    EWEKTSNKDSDWYKSSKMWWCSSQVG-----------------------NDDFRGEMTDC
IRAK-Un_dq_Smoe    -------------------------EEEDVLSFSLSQSSKMWWCSSQVGNDDFRGEMTDC
IRAK-Un_dh_Smoe    --------------------------------------------------------MTSM
IRAK-Un_dp_Smoe    --------------------------------------------------------SIGA
IRAK-Un_bk-2_Smoe  ---------------------------------------------------------MRF
IRAK-Un_bk-1_Smoe  ---------------------------------------------------------MRF
IRAK-Un_ck_Smoe    -----------------------------------------------------LTQPTRL
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    -----------------------------------------------------LTQPTRL
IRAK-Un_v-2_Smoe   --------------------------------------------------------T-AP
IRAK-Un_de_Smoe    -------------------------------------------------------PTSGI
IRAK-Un_dk_Smoe    -------------------------------------------------------LTTGI
IRAK-Un_bv_Smoe    -------------------------------------------------------RTTTL
IRAK-Un_ay-2_Smoe  ---------------------------------------------------------TRA
IRAK-Un_ay-1_Smoe  ---------------------------------------------------------TRA
IRAK-Un_df_Smoe    --------------------------------------------------------T-SP
IRAK-Un_bt_Smoe    -----------------------------------------------------------G
IRAK-Un_r_Smoe     ----------------------------------------------------------TM
IRAK-Un_bb_Smoe    ---------------------------------------------------------TVI
IRAK-Un_v-1_Smoe   --------------------------------------------------------T-AP
IRAK-Un_bx-1_Smoe  -----------------------------------------------------VSSTPSM
LRR10a_d-2_Smoe    --------------------------------------------------------KSNS
IRAK-Un_cz_Smoe    --------------------------------------------------------RTVV
IRAK-Un_e_Smoe     --------------------------------------------------------TLRI
IRAK-Un_dn_Smoe    ---------------------------------------------------------SKV
IRAK-Un_do_Smoe    --------------------------------------------------------S-RP
IRAK-Un_br-1_Smoe  ---------------------------------------------------ILTRCCSLC
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  -----------------------------------------------------VSSTPSM
IRAK-Un_am-1_Smoe  --------------------------------------------------------T-CA
IRAK-Un_bj-2_Smoe  ---------------------------------------------------------IKT
IRAK-Un_bj-1_Smoe  ---------------------------------------------------------IKT
RKF3_a-2_Smoe      ---------------------------------------------------------TRV
IRAK-Un_bo-2_Smoe  ---------------------------------------------------------SAN
IRAK-Un_dc_Smoe    --------------------------------------------------------T-SP
IRAK-Un_k-2_Smoe   -----------------------------------------------------LTQPTRL
IRAK-Un_bo-1_Smoe  ---------------------------------------------------------SAN
IRAK-Un_cb_Smoe    -------------------------------------------------------IGSTV
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ---------------------------------------------------------TRL
IRAK-Un_t_Smoe     ---------------------------------------------------------TRL
IRAK-Un_dd_Smoe    -------------------------------------------------------VETKS
IRAK-Un_bp-1_Smoe  ---------------------------------------------------------TRV
IRAK-Un_bp-2_Smoe  ---------------------------------------------------------TRV
IRAK-Un_k-1_Smoe   -----------------------------------------------------LTQPTRL
IRAK-Un_bd_Smoe    --------------------------------------------------------MTSM
IRAK-Un_h_Smoe     -------------------------------------------------------VTTQV
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ---------------------------------------------------------TRV
IRAK-Un_ap-1_Smoe  ---------------------------------------------------------TRA
IRAK-Un_ap-2_Smoe  ---------------------------------------------------------TRA


IRAK-Un_aw_Smoe    AGTHGYLAPEF-----V--------------Y-RNE---LTTKSDVYSFGVLMLELISGR
IRAK-Un_co_Smoe    RKSRSIS-----------------------------------------------------
IRAK-Un_ax_Smoe    AGTVGYLALEY-----A--------------L-SGQ---FTEKADVYSFGILVLEILSGR
IRAK-Un_br-2_Smoe  LKVAAYAAPEL-----L--------------Q-RGTQSLPSPKSNVWSFGVVLLEILTGR
IRAK-Un_bw_Smoe    RGTPGYMAPEW-----L-------------------------HSGVGGFG--LLELVSGR
IRAK-Un_ca_Smoe    ----------------------------------MK---VSDKLDVYSFALCWKWLPDYK
IRAK-Un_am-2_Smoe  QGTLGYLDPEY-----Y--------------R-KYQ---LTDKSDVYSFGVVLLELVTSQ
IRAK-Un_da_Smoe    MGTFGYVAPEY-----A--------------N-TGL---LNERSDVYSFGVLLMEVVTGR
IRAK-Un_dg_Smoe    --TGGYVDPEI-----V--------------H-RGV---YSRAGDVFSFGVLLLEVLSGK
IRAK-Un_dj_Smoe    ----------------------------------SD---VFPVYDIYCYGKVLLDLVSGL
IRAK-Un_dm_Smoe    RGTTGYLDPEY-----Y--------------M-TQV---LTTKSDVFSFGVVLLEIVCGR
IRAK-Un_ag_Smoe    VGTRWYKAPEL-----L--------------YGSTS---YNFAVDLWAVGCILGELIQGE
IRAK-Un_dq_Smoe    VGTRWYKAPEL-----L--------------YGSTS---YNFAVDLWAVGCILGELIQGE
IRAK-Un_dh_Smoe    RGTPGYLAPEY-----L--------------Q-VGT---ITEKSDVFSFGVLLLEIITGC
IRAK-Un_dp_Smoe    QGTAGYLDPEY-----H--------------Q-CYA---LTDKSDVYSFGVLLMELITAK
IRAK-Un_bk-2_Smoe  LRSRSQTSEQD-----P--------------D-SPV---ASCAYDVYCFGKVLLELVSGK
IRAK-Un_bk-1_Smoe  LRSRSHFLLKRCLFFRV--------------D-SPV---ASCAYDVYCFGKVLLELVSGK
IRAK-Un_ck_Smoe    VGTFGYMSPEY-----A--------------R-YGD---VSPFLDVYSFGVVLFEIISAQ
IRAK-Un_cn_Smoe    ----------L-----K-------------------------LQDVYSFGSLVLELVTGK
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    VGTFGYMSPEY-----A--------------R-YGD---VSPFLDVYSFGVVLFEIISAQ
IRAK-Un_v-2_Smoe   QGTPGYVDPDY-----H--------------Q-SFQ---LSDKSDVYSFGVVLVEMITSM
IRAK-Un_de_Smoe    KGTFGYTDPEY-----I--------------F-TKV---FNEKSDVYSFGVLLFELMSGR
IRAK-Un_dk_Smoe    AGTLGYIAPEV-----V--------------S-TCR---LSEKTDVYSFGIVLLELLTGR
IRAK-Un_bv_Smoe    AGTLGYIAPEV-----G--------------V-TYK---FTPASDVYSYGVVTLEVVTGR
IRAK-Un_ay-2_Smoe  AGTAGYLAPEY-----A--------------L-YGQ---LTVKADVYSFGILVLEIISGR
IRAK-Un_ay-1_Smoe  AGTAGYLAPEY-----A--------------L-SGQ---LTEKADVYSFGILVLEIISGR
IRAK-Un_df_Smoe    VGTFAYIDPEY-----Q--------------R-EGS---FNAKSDVFAFGIILLQLLTAT
IRAK-Un_bt_Smoe    LGTQGYVAPEY-----V--------------K-NIS---LRSFL----------------
IRAK-Un_r_Smoe     VGTPGYMDPEY-----F--------------Q-TAK---FTTKSDVYSFGVVLLELLTGR
IRAK-Un_bb_Smoe    AG----------------------------------------------------------
IRAK-Un_v-1_Smoe   QGTPGYVDPDY-----H--------------Q-SFQ---LSDKSDVYSFGVVLVEMITSM
IRAK-Un_bx-1_Smoe  RGTVCYVAPEY-----G--------------G-GGV---LTEKSDVYSFGVLLLVVVSGR
LRR10a_d-2_Smoe    DEDGFYVPPED-----YSTTYSLSRATSMSAA-STT---ATPKGDVYAFGVVLLELVTGR
IRAK-Un_cz_Smoe    AGTHGYLAPEF-----V--------------Y-RNE---LTTKSDVYSFGVLMLELISGR
IRAK-Un_e_Smoe     QGTPGYCDPEL-----M--------------T-TFR---LTDKSDVYSFGVVLLELVTGQ
IRAK-Un_dn_Smoe    AGTFGYMAPEY-----A--------------V-HRR---LSPKADVFSFGVPVLVILSGR
IRAK-Un_do_Smoe    VPYSGYVDPEF-----S--------------H-TGV---LTEKSDVYSFGVLLLELVSSR
IRAK-Un_br-1_Smoe  LKVAAYAAPEL-----L--------------Q-RGAQSLPSPKSNVWSFGVVLLEILTGR
IRAK-Un_av-2_Smoe  STNLAYTPPEY-----L--------------R-TGR---VTPESVIYSYGTVLLDLLSGK
IRAK-Un_av-1_Smoe  STNLAYTPPEY-----L--------------R-TGR---VTPESVIYSYGTVLLDLLSGK
IRAK-Un_bx-2_Smoe  RGTVCYVAPEY-----G--------------G-GGV---LTEKSDVYSFGVLLLVVVSGR
IRAK-Un_am-1_Smoe  QGTLGYLDPEY-----Y--------------R-KYQ---LTDKSDVYSFGVVLLELVTSQ
IRAK-Un_bj-2_Smoe  SAMLGYLAPEY-----G--------------V-IGH---LHEKSDVYAFGILLLELLTGR
IRAK-Un_bj-1_Smoe  SAMLGYLAPEY-----G--------------V-IGH---LHEKSDVYAFGILLLELLTGR
RKF3_a-2_Smoe      AGTPIYMAVEY-----A--------------L-YGQ---CSDKVDVYSFGVLLLELMSGR
IRAK-Un_bo-2_Smoe  GSSSHFADPAA-V---Y--------------N-TYR---VDPKSDVYSYGVFLLELISGR
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   VGTFGYMPPEY-----A--------------R-FGD---VSPKIDVYSFGVVLYEIISAK
IRAK-Un_bo-1_Smoe  GSSSHFADPAA-V---Y--------------N-TYR---VDPKSDVYSYGVFLLELISGR
IRAK-Un_cb_Smoe    VGTYGYMAPEQ-----F--------------Q-N-R---ATLQTDLYGLGGTLLFMLSGR
IRAK-Un_cs_Smoe    -GTGSQEDLEI-----I--------------S-KQDCEGVTDKMDVLGFGFLVLEITSGR
IRAK-Un_cu_Smoe    LRLSQTTEQGD-----Q--------------G-SAV---ASCAYDVYCFGKVLLELVTGK
IRAK-Un_t_Smoe     LRLSQTTEQGD-----Q--------------G-SAV---ASCAYDVYCFGKVLLELVTGK
IRAK-Un_dd_Smoe    S--------------------------------------LHDVALCYTSGV---------
IRAK-Un_bp-1_Smoe  AGTIGYLSPEY-----A--------------M-RGQ---LTEKADVYSFGVLVLEIVSGR
IRAK-Un_bp-2_Smoe  AGTIGYLSPEY-----A--------------M-RGQ---LTEKADVYSFGVLVLEVVSGR
IRAK-Un_k-1_Smoe   VGTFGYMPPEY-----A--------------R-FGD---VSPKIDVYSFGVVLYEIISAK
IRAK-Un_bd_Smoe    RGTPGYLAPEY-----L--------------Q-VGT---ITEKSDVFSFGVLLLEIITGC
IRAK-Un_h_Smoe     AGTIGYIAPEY-----H--------------Q-TCK---FTVSSDVYSMGIVLGVLISGR
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    AGTFGYLAPEY-----A--------------L-RGK---LTEKADVYSFGILLLEILSGR
IRAK-Un_ap-1_Smoe  AGTVGYLAPEY-----A--------------L-SGQ---LTEKADVYSFGILVLEILSGR
IRAK-Un_ap-2_Smoe  TGTVGYLAPEY-----A--------------L-SGQ---LTEKADVYSFEILVLEILSGR


IRAK-Un_aw_Smoe    KPAMPVD--VVDW-------------QTIF-EW-AT-PLV--------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ISMDFTL--SDGD-------------SFLL-ERVTW-N----------------------
IRAK-Un_br-2_Smoe  QNRDEMF--AVEE-------------QDLV-GW-TA-PYLA-------------------
IRAK-Un_bw_Smoe    KVVALPS--SAVITSPG--------EDGLIMSS-C----WE-------------------
IRAK-Un_ca_Smoe    LSIPVCL--AGGA-------------QS---SWR-H-E----------------------
IRAK-Un_am-2_Smoe  KAIDFSR--DQDD-------------INLA-MY-VI-AR---------------------
IRAK-Un_da_Smoe    DPVDYSR--PPGE-------------VNLV-DW-LK-L----------------------
IRAK-Un_dg_Smoe    QAFS--EET-----------------GMLV-EW-AQ-QFLQ-------------------
IRAK-Un_dj_Smoe    DISSCC---DGFG-------------EAWL-HR-AL-PLME-------------------
IRAK-Un_dm_Smoe    EPLNLRR--PRSE-------------ASLV-DW-VT------------------------
IRAK-Un_ag_Smoe    PLFPGAS--DIDQ-------------LSRV-VRV-L-GVPNETIWPGISSLPDYDKICFN
IRAK-Un_dq_Smoe    PLFPGAS--DIDQ-------------LSRV-VRV-L-GVPNETIWPGISSLPDYDKICFN
IRAK-Un_dh_Smoe    RNKYMSS--DYL---------------R---SF-SL-GDF--------------------
IRAK-Un_dp_Smoe    PAVDFSR--ERV---------------NLA-PY-AV-GML--------------------
IRAK-Un_bk-2_Smoe  LGISGTM--DPGA-------------DTWV-ET-IL-PLID-------------------
IRAK-Un_bk-1_Smoe  LGISGTM--DPGA-------------DTWV-ET-IL-PLID-------------------
IRAK-Un_ck_Smoe    EAIVRTQ--SGILSNKDE----QKGLATLF-ED-VLQD-D--------------------
IRAK-Un_cn_Smoe    ASSDRKH--KREALA-------------AI----------E-------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    EAIVRTQ--SGILSNKDE----QKGLATLF-ED-VLQD-D--------------------
IRAK-Un_v-2_Smoe   KVVDFTR--DKRE-------------VNLA-AL-AV-GK---------------------
IRAK-Un_de_Smoe    HPQHGLM--D---Y-V--------Q---MA-SL-GV------------------------
IRAK-Un_dk_Smoe    KPLVLGN--LGE-------------IVSVT-TW-VK-A----------------------
IRAK-Un_bv_Smoe    RVIGSSK--EKDH-----------NAWLLV-PW-VE-E----------------------
IRAK-Un_ay-2_Smoe  KNMDFS------E-------------FFLL-EW-AW-N----------------------
IRAK-Un_ay-1_Smoe  KNMDFTL--LDSE-------------FFLL-EW-AW-N----------------------
IRAK-Un_df_Smoe    SPVGII-------------------------HK-VS-TA---------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     QAMLGSE-------------------RSLV-SW-VL-LQ---------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   KVVDFTR--DKRE-------------VNLA-AL-AV-GK---------------------
IRAK-Un_bx-1_Smoe  RPLQVVA--APLSE-F--------ERANLI-SW-AR-H----------------------
LRR10a_d-2_Smoe    RPNDVAARSSSSR-------------RSLV-DW-IG-ELFK-------------------
IRAK-Un_cz_Smoe    KPAMPVD--VVDW-------------QTIF-EW-AT-PLV--------------------
IRAK-Un_e_Smoe     KPLDFGR--ESSR-------------VNLA-FY-SL-PL---------------------
IRAK-Un_dn_Smoe    KCVDLAR--SSGQ-------------EHIV-QM-TW-K----------------------
IRAK-Un_do_Smoe    PVTTAG---D----------------KHIL-DW-AH-EFY--------------------
IRAK-Un_br-1_Smoe  QNRDEMF--AVEE-------------QDLV-GW-TA-PYLA-------------------
IRAK-Un_av-2_Smoe  HIPPS-HAL----------------------------DLI--------------------
IRAK-Un_av-1_Smoe  HIPPS-HAL----------------------------DLI--------------------
IRAK-Un_bx-2_Smoe  RPLQVVA--APLSE-F--------ERANLI-SW-AR-H----------------------
IRAK-Un_am-1_Smoe  KAIDFSR--DQDD-------------INLA-MY-VI-AR---------------------
IRAK-Un_bj-2_Smoe  KPMYADG--SSLSVT------------NLA-NF-VR-PLFD-------------------
IRAK-Un_bj-1_Smoe  KPMYADG--SSLSVT------------NLA-NF-VR-PLFD-------------------
RKF3_a-2_Smoe      SALDTSQ--ENPV------------HYHIV-DW-AW-SLV--------------------
IRAK-Un_bo-2_Smoe  QAINRSR--PAQPSP------------GIV-EW-AR-SLQE-------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   DAIVRTV--EGDDSNPDPTQRVAKGLVMMF-DT-ALKS----------------------
IRAK-Un_bo-1_Smoe  QAINRSR--PAQPSP------------GIV-EW-E-------------------------
IRAK-Un_cb_Smoe    SPATFPQ--KRLR-------------VDFQ-NFV-S------------------------
IRAK-Un_cs_Smoe    ELQSN--PEEM---------------IQLA----------E-------------------
IRAK-Un_cu_Smoe    LDISGTS--DPNA-------------DAWL-EW-AL-PLID-------------------
IRAK-Un_t_Smoe     LDISGTS--DPNA-------------DAWL-EW-AL-PLID-------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  DNLDTSL--PTEM-------------VYLL-EW-AW-H----------------------
IRAK-Un_bp-2_Smoe  DNLDTSL--PTEM-------------IYLL-EW-AW-H----------------------
IRAK-Un_k-1_Smoe   DAIVRTV--EGDDSNPDPTQRVAKGLVMMF-DT-ALKS----------------------
IRAK-Un_bd_Smoe    RNKYMSS--DYL---------------R---SF-SL-GGF--------------------
IRAK-Un_h_Smoe     EPTDEFF--KDF-------------PGGIV-PW-MC-Y----------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    SSIDFEL--PPEK-------------SFLL-EW-AW-E----------------------
IRAK-Un_ap-1_Smoe  ISMDFTL--SDGD-------------SFLL-ER-AW-N----------------------
IRAK-Un_ap-2_Smoe  ISMDFTL--SDGD-------------SFLL-ER-AW-N----------------------


IRAK-Un_aw_Smoe    --------------QSQQLQEIIDPSL--T----------SIP-----------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------VFQSGHLLEMIDKRL--D----------VDD-----------------
IRAK-Un_br-2_Smoe  --------------NDKKLFLVVDPEL--K----------GMF-----------------
IRAK-Un_bw_Smoe    ---------------QKRLSGVTCCSITLI----------EE------------------
IRAK-Un_ca_Smoe    ------------KLRSGKLMEMLEEE----------------------------------
IRAK-Un_am-2_Smoe  -------------TERGDVMDVVDKRL--L----------DFHNGDN-------------
IRAK-Un_da_Smoe    ------------MLATRRMDDIADPRL--E----------EK------------------
IRAK-Un_dg_Smoe    --------------SRDRMMDLVDKSM--S----------NV------------------
IRAK-Un_dj_Smoe    ------------FGKRDAFLRLVDPTL--V----------LDED----------------
IRAK-Un_dm_Smoe    -----------------NIQSIIDPSI--S----------ASYT----------------
IRAK-Un_ag_Smoe    DDRPPVTLARILPRASGEALRLIEKLL---------------------------------
IRAK-Un_dq_Smoe    DDRPPVTLARILPRASGEALRLIEKLL---------------------------------
IRAK-Un_dh_Smoe    -------------SRQKSFTKSISKTR--KNLCDGGSSGGVADK----------------
IRAK-Un_dp_Smoe    --------------QAGAFEQIIDPHL--E----------AARN----------------
IRAK-Un_bk-2_Smoe  ------------RHEKENLSKIVDSSL--L----------VDDD----------------
IRAK-Un_bk-1_Smoe  ------------RHEKENLSKIVDSSL--L----------VDDD----------------
IRAK-Un_ck_Smoe    ------------TNGKERLRDLMDPRL--G----------DN------------------
IRAK-Un_cn_Smoe    ---------------AGMGHTIMDKRL--E----------NE------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------TNGKERLRDLMDPRL--G----------DN------------------
IRAK-Un_v-2_Smoe   -------------IATDCLDEIIDPAL--M----------IQACRN--------------
IRAK-Un_de_Smoe    ------------DEENSDWIELLDSRL--N----------GNC-----------------
IRAK-Un_dk_Smoe    ------------MNQQGKGMETFDSEL--A----------SSS-----------------
IRAK-Un_bv_Smoe    ------------QYAAGKLLGVVDPR----------------------------------
IRAK-Un_ay-2_Smoe  ------------AFQSGNLQEIIDKRL--E----------VGE-----------------
IRAK-Un_ay-1_Smoe  ------------AFQSGNLQEIIDKRL--E----------VGD-----------------
IRAK-Un_df_Smoe    -------------VDQGHLMEILDTSA--G-----------EWP----------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     -------------RGKSNTCSLFDPRI--F----------LPEN----------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   -------------IATDCLDEIIDPAL--M----------IQACRN--------------
IRAK-Un_bx-1_Smoe  ------------AAQAGRGLDLVDPLL--A----------GAY-----------------
LRR10a_d-2_Smoe    ---------------SGHVSEAVDPSL--V----------AEASVLLAAGNGDSS----N
IRAK-Un_cz_Smoe    --------------QSQQLQEIIDPSL--T----------SIP-----------------
IRAK-Un_e_Smoe     -------------IRMEMIEELVDPKM--G----------VVSA----------------
IRAK-Un_dn_Smoe    ------------LCEAGKLDECVDWKL--G----------SDY-----------------
IRAK-Un_do_Smoe    ------------NFSDARLVEMVDSTL--R----------DQID----------------
IRAK-Un_br-1_Smoe  --------------NDKKLFLVVDPEL--K----------GMF-----------------
IRAK-Un_av-2_Smoe  --------------RGKNILMLMDSYL--E----------GQF-----------------
IRAK-Un_av-1_Smoe  --------------RGKNILMLMDSYL--E----------GQF-----------------
IRAK-Un_bx-2_Smoe  ------------AAQAGRGLDLVDPLL--A----------GAY-----------------
IRAK-Un_am-1_Smoe  -------------TERGDVMDVVDKRL--L----------DFHNGDN-------------
IRAK-Un_bj-2_Smoe  ---------------SGHLDTAIDPSL--G----------TKF-----------------
IRAK-Un_bj-1_Smoe  ---------------SGHLDTAIDPSL--G----------TKF-----------------
RKF3_a-2_Smoe      --------------KAGRLPEIIDEKI--R----------DSDP----------------
IRAK-Un_bo-2_Smoe  --------------SSSSMEGMVDKSL--V----------GT------------------
IRAK-Un_dc_Smoe    ------------------------------------------WP----------------
IRAK-Un_k-2_Smoe   ------------PDATENLKKLVDPAL--G----------TD------------------
IRAK-Un_bo-1_Smoe  --------------SSSSMEGMVDKSL--V----------GT------------------
IRAK-Un_cb_Smoe    --------------ASPSMTRVVEKLL---------------------------------
IRAK-Un_cs_Smoe    --------------QKLAIERWIDPRI--R----------GV------------------
IRAK-Un_cu_Smoe    ------------RHNKEGIMKLVDPSL--I----------VDED----------------
IRAK-Un_t_Smoe     ------------RHNKEGIMKLVDPSL--I----------VDED----------------
IRAK-Un_dd_Smoe    ---------------GGRCLGFIDKEL--Y----------ELS-----------------
IRAK-Un_bp-1_Smoe  ------------LYENNRPLELLDPEV--P-----------EF-----------------
IRAK-Un_bp-2_Smoe  ------------LHENNRALELLDPEV--P-----------EF-----------------
IRAK-Un_k-1_Smoe   ------------PDATENLKKLVDPAL--G----------TD------------------
IRAK-Un_bd_Smoe    -------------SRQKSFTKSISKTR--KNLCDGGSSGGIADK----------------
IRAK-Un_h_Smoe     ------------LVQSGQELRGIDPTL--L----------KPAARGGGEGGGDDTLGQTP
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------LYEEGQWLDLVDEKL--P----------PET-----------------
IRAK-Un_ap-1_Smoe  ------------VFQSGHLLEMIDKRL--D----------VGD-----------------
IRAK-Un_ap-2_Smoe  ------------VFQSGHLLEMIDKRL--D----------VGD-----------------


IRAK-Un_aw_Smoe    ------APAHIQMLVDLIYSCTQHVASMR-PRMSYVVHQLDQLKDVA-ALATLEP-T---
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ----ERDIHEMERVFLVALHCTHASGSRR-PSMFRVVGMLMGDMEMV-A---PSP-----
IRAK-Un_br-2_Smoe  ------PARSVSLFAKLAAQCLQRDPAAR-PSMDQVVQSLEHVQAER-DH-HIKL-F---
IRAK-Un_bw_Smoe    --------DLSEQRAKEMLLCACHEQLQR-PSIGGALKMLE-------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  -AFEVVTRETIVGVVMLALNCLRESKDER-PTMKEVSDELNYIIETY-------------
IRAK-Un_da_Smoe    -----PSPRALKKALITAFQCVHPDVRKR-PTMGHVVHLLEAENFQL-PD-VQKHSF---
IRAK-Un_dg_Smoe    ------CPMELYSVCELARLCTQRESSSR-PSMRDVSDLLVQSLAI--PAEA--------
IRAK-Un_dj_Smoe    -----H-VKELMLLAVIAKSCLDPEHAQH-QTMSNVLHMLQNPAFF--------------
IRAK-Un_dm_Smoe    -------PEAMWRVVEVAYASVETCSARR-PDMAGVVKELDDALIIE-NNA-SQYML---
IRAK-Un_ag_Smoe    ----------------------VYDPASR-LSASQALS----------------------
IRAK-Un_dq_Smoe    ----------------------VYDPASR-LSASQALS----------------------
IRAK-Un_dh_Smoe    ----Y-QAAGMERLKAVAYLCVQDDPDMR-PSMSTALKMMEGLIELP-ETP-PLSSL---
IRAK-Un_dp_Smoe    ----CMVRAMALRVAEIAFQCLAANPEDR-PRMGEVAAALIHV-----------------
IRAK-Un_bk-2_Smoe  -----L-LEEVWAVAIVAKMCLNPKPSRR-PAIRQVLKALENPQRVV-REE-NF------
IRAK-Un_bk-1_Smoe  -----L-LEEVWAVAIVAKMCLNPKPSRR-PAIRQVLKALENPQRVV-REE-NF------
IRAK-Un_ck_Smoe    -----YPLEAAWSLAKLAGACTKENPELR-PNMRTVVVALMTLMH---------------
IRAK-Un_cn_Smoe    --------NQIAKMGEIAAWCMSD-STRQ-PSMVEVSSTLSQVTAMV-LRS-A-------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    -----YPLEAAWSLAKLAGACTKENPELR-PNMRTVVVALMTLVH---------------
IRAK-Un_v-2_Smoe   ----PVVRCMIQRMAELAFRCLAHEKDAR-PSMAEVFDEVEGIRHSC-LSP-GDHS----
IRAK-Un_de_Smoe    ------NLQELAKLASIAHRCVRKDPETR-PPMREIVQWLSRFGM---------------
IRAK-Un_dk_Smoe    ----PSSGPVLVQMMQLALHCTSDWPSRR-PSMSKVVAFLELLQESL-LR-EEE--E---
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  -----REIHEIKRVFTVALHCTQASQNKR-PVMYKVVGMLMGDMDIS-GT-ISKPGF---
IRAK-Un_ay-1_Smoe  -----QEIHEIKRVFTVALHCTQASQNKR-PVMYRVVGMLMGDMDIS-GT-ISKPGF---
IRAK-Un_df_Smoe    -------LAAATQLACIGLNCAEVQRKNR-PELENVLQMLETMNHLF-RSE-ERPKS---
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     -------SAALEEVLRLALQCTSFDAEHR-PTISSIATTLELKTIFQ-QSG--T-TI---
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ----PVVRCMIQRMAELAFRCLAHEKDAR-PSMAEVFDEVEGIRHSC-LSP-GDHS----
IRAK-Un_bx-1_Smoe  ------SKEQATLFISLALLCLQRVPSLR-PSMSDVVKIFSGEAELP-AL-PFE--F---
LRR10a_d-2_Smoe    G--SSGRRREVMQVLKIACSCVLSFPKER-PSMYEVYHMLRAVGEDYYPVENLNP-LHNH
IRAK-Un_cz_Smoe    ------APAHIQMLVDLIYSCTQHVASMR-PRMSYVVHQLDQLKDVE-SLQPRQQ-Q---
IRAK-Un_e_Smoe     -----VERCSVARVAALADKCLAECGANR-PKMREVVEELTSIREEM-RS----------
IRAK-Un_dn_Smoe    ------DPDEVYRMVHIALLCTQEREELR-PVMSDVVTMLLGRLDLH-PLPTHAPGT---
IRAK-Un_do_Smoe    -------PDELKKIITVSRLCSQSEAASR-PSMKQVVNLLLDNAIAI-FPP-LSFSA---
IRAK-Un_br-1_Smoe  ------PARSVSLFAKLAAQCLQRDPAAR-PSMDQVVQSLEHVQAER-DH-HIKL-F---
IRAK-Un_av-2_Smoe  ------SNDDGTELVRLASRCLQYEPRER-PTAKMLVQALLPLQKQA-DVPSYVL-M---
IRAK-Un_av-1_Smoe  ------SNDDGTELVRLASRCLQYEPRER-PTAKMLVQALLPLQKQA-DVPSYVL-M---
IRAK-Un_bx-2_Smoe  ------SKEQATLFISLALLCLQRVPSLR-PSMSDVVKIFSGEAELP-AL-PFE--F---
IRAK-Un_am-1_Smoe  -AFEVVTRETIVGVVMLALNCLRESKDER-PTMKEVSDELNYIIETY-------------
IRAK-Un_bj-2_Smoe  ------SATGAIGMASIAFSCVAPVPQLR-PSMGQVVQRLYEIETLA-DGA-G---A---
IRAK-Un_bj-1_Smoe  ------SATGAIGMASIAFSCVAPVPQLR-PSMGQVVQRLYEIETLA-DGG-GG--A---
RKF3_a-2_Smoe      -----AAIVLQQRFVLVGILCAHLLVAVR-PPISQALKLLEGNDTIP-PIP-DR------
IRAK-Un_bo-2_Smoe  --------EEAGTLLLLGLHCTAQSPEKR-PTMSQVSQQVERILDKE-RGG-I---V---
IRAK-Un_dc_Smoe    -------LAAATQLACIGLNCAECQRKNR-PELENVLQMLETMNHLF-RSE-ERPKS---
IRAK-Un_k-2_Smoe   -----YPFDSIWKLAKLAEACTQETPENR-PNMRAVVVALMTLCSTT-QE-L---DF---
IRAK-Un_bo-1_Smoe  --------EEAGTLLLLGLHCTAQSPEKR-PTMSQVSQQVERILDKE-RGG-I---V---
IRAK-Un_cb_Smoe    ----------------------EPAPEDRYQSADEVIRALQDGE----------------
IRAK-Un_cs_Smoe    ------PEMEARRMIQMSMLCLQSNPEAR-PSMGKLIPAVQ-------------------
IRAK-Un_cu_Smoe    -----L-LEEVWAMAIVAKLCLHGRASKR-PQIRHVLKALENPQRVT-REE-NF------
IRAK-Un_t_Smoe     -----L-LEEVWAMAIVAKLCLHGRASKR-PQIRHVLKALENPQRVT-REE-NF------
IRAK-Un_dd_Smoe    ----LRNRRV-ISINSF-LYTGLRGPVNR-PRIRSILSNI--------------------
IRAK-Un_bp-1_Smoe  ------DEGEVLRVIQVALLCSQALASAR-PTMSHAVAMLLGTATID-VT-SLQPGY---
IRAK-Un_bp-2_Smoe  ------DEGEVLRVIQVALLCSQALASAR-PTMSHAVAMLLGTATID-VT-SLQPGY---
IRAK-Un_k-1_Smoe   -----YPFDSIWKLAKLAEACTQETPENR-PNMRAVVVALMTLCSTT-QE-L---DF---
IRAK-Un_bd_Smoe    ----Y-QAAGMARLKAVAYLCVQDDPDMR-PSMSTALKMMEGLIELP-ETP-PLSSL---
IRAK-Un_h_Smoe     GFANLDEITEMKRAMRIACLCTKLNPQDR-PSTKDVLVMLNPGKLEN-V-----------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    -----CPKEELQRVMTVSLICTQGAPSAR-PAMSRVVAMLLGDIAPT-LD-ITRPGF---
IRAK-Un_ap-1_Smoe  ----ERDIHEMERVFLVALHCTQASGSKR-PSMFRVVGMLMGDMEIG-GT-ISRPGF---
IRAK-Un_ap-2_Smoe  ----ERDIHKMERVFLVALHCTQASGSRR-SSMFRVVGMLMGDMEIG-GT-ISRPGF---


IRAK-Un_aw_Smoe    ------------------------------SSS-TA-SSSS----SSEAM----------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------DAS----AGSD----SRKPL----------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------WFF-FP-A-----KVSKKI-----------
IRAK-Un_dg_Smoe    --------------------------------------AAP-------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    --------------------------------S-MD-S----------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    --------------------------------H----------------F----------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------TAS-LR-RS--SHSSWNGSL----------
IRAK-Un_bk-1_Smoe  ------------------------------TAS-LR-RS--SHSSWNGSL----------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   --------------------------------P-IR-D----------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------SK----------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------LCD-LR-Q----------------------
IRAK-Un_ay-1_Smoe  ------------------------------LCD-LR-Q-------N--------------
IRAK-Un_df_Smoe    --------------------------------A-AP-T-----------L----------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     --------------------------------N-LQ-E-----------V----------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   --------------------------------P-IR-D----------------------
IRAK-Un_bx-1_Smoe  ------------------------------SP-------------S--------------
LRR10a_d-2_Smoe    ARNHQFQQQQRPRRSGRKFFGNRCGDQEEHDLESGGAQAAP----APPPL----------
IRAK-Un_cz_Smoe    ------------------------------QQQ-IQ-----------E-V----------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------YLK-T-------------------------
IRAK-Un_do_Smoe    --------------------------------T-IK-D-----------DDGDGDGDGKQ
IRAK-Un_br-1_Smoe  ------------------------------DAS----VGSD----SRKPL----------
IRAK-Un_av-2_Smoe  ------------------------------GI-----PRGE----TLPPL----------
IRAK-Un_av-1_Smoe  ------------------------------GI-----PRGE----TLPPL----------
IRAK-Un_bx-2_Smoe  ------------------------------SP-------------S--------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------SA----------------------------
IRAK-Un_bj-1_Smoe  ------------------------------SA----------------------------
RKF3_a-2_Smoe      ------------------------------PPP-YI-FA--GHTLV--------------
IRAK-Un_bo-2_Smoe  ------------------------------AA----------------------------
IRAK-Un_dc_Smoe    --------------------------------A-AP-T-----------L----------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------AA----------------------------
IRAK-Un_cb_Smoe    ------------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------SSS-LR-SRTSSHSSWNASL----------
IRAK-Un_t_Smoe     ------------------------------SSS-LR-SRTSSHSSWNASL----------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------FAA-LQ-N-------AAPGF----------
IRAK-Un_bp-2_Smoe  ------------------------------FAA-LQ-N-------AAPGF----------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    --------------------------------H----------------F----------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------LPD-L-------------------------
IRAK-Un_ap-1_Smoe  ------------------------------LFD-LR-Q-------N--------------
IRAK-Un_ap-2_Smoe  ------------------------------LFD-LR-Q-------N--------------


IRAK-Un_aw_Smoe    ---TMT------------------------IRSA--------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ---IEA------------------------LREC--------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ---------------------CLIS-----LA----------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ---IGS------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ---F---------------LG---------YR----------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ---FGS------------------------WRHSSSETVIPA-TLKEESLQPDHYG--G-
IRAK-Un_bk-1_Smoe  ---FGS------------------------WRHSSSETVIPA-TLKEESLQPDHYG--G-
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ---IK-------------------------ID----------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ---F---------------LC---P----ILQ----------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ---FGKLLSNSLCLVLFSELR---PEVVDLIR----------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ---IK-------------------------ID----------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ---VLA------------------------APDV--------------------------
IRAK-Un_cz_Smoe    ---VYP------------------------ARDA--------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    HRRVN-------------------------SD----------------------------
IRAK-Un_br-1_Smoe  ---IEA------------------------LREC--------------------------
IRAK-Un_av-2_Smoe  --ALSP------------------------LGEA--------------------------
IRAK-Un_av-1_Smoe  --ALSP------------------------LGEA--------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ---F---------------LC---P----ILQ----------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    --------------------------------------------------------SPVV
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ---FGS------------------------WRHSSSENVIASGVLREEYVGGGGGGGGG-
IRAK-Un_t_Smoe     ---FGS------------------------WRHSSSENVIASGVLREEYVGGGGGG--G-
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ---Y---------------TDA--------LV----------------------------
IRAK-Un_bp-2_Smoe  ---Y---------------TDA--------LV----------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ---F---------------LG---------YR----------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ---------------------------------------ASSIRKHS---HSQGSFQDHG
IRAK-Un_bk-1_Smoe  ---------------------------------------ASSIRKHS---HSQGSFQDHG
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    AGESFFDYAAKSRKPYGTKVVLTRFPDSLTISIPRAGV-GAAAAT--------G------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    -----------------------------------GGGGGDPSRKHSGTSHSQGSITGEQ
IRAK-Un_t_Smoe     -----------------------------------GGGGGDPSRKHSGTSHSQGSITGEQ
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ------------------------------------------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ---------------------------AATTTTTMI--------E---------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ---------------------------SSPGAA--V--------A---------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    -----------------E-----L--ESSEGDG--IVQA---------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    -----------------------S------KVK---------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  HHHRRPGSSEIFPEPL--------------------------------------------
IRAK-Un_bk-1_Smoe  HHHRRPGSSEIFPEPL--------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ---------------------------------------------S--------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   -----------------E-----V------KIS-----V---L-----------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    -----------------------------QLLL--L------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ----------------------------PEQTG--I------------------------
IRAK-Un_df_Smoe    -----------------VI---IL------EF----------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     -----------------NITSLSL------QLN-----IGALL-----------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   -----------------E-----V------KIS-----V---R-----------------
IRAK-Un_bx-1_Smoe  ----------------------------PPGCG--F------------------------
LRR10a_d-2_Smoe    ---------------------------A-EAAA--I--------A---------------
IRAK-Un_cz_Smoe    ---------------------------RSKE-----------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    -----------------D------------SLS-----I---HSAT--------------
IRAK-Un_br-1_Smoe  ---------------------------SSPGAA--V--------A---------------
IRAK-Un_av-2_Smoe  ---------------------------CSRNDL--T--------AVHEILVKTGYKDDEG
IRAK-Un_av-1_Smoe  ---------------------------CSRNDL--T--------AVHEILVKTGYKDDEG
IRAK-Un_bx-2_Smoe  ----------------------------PPGCG--F------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ---------------------------------------------T--------------
IRAK-Un_bj-1_Smoe  ---------------------------------------------T--------------
RKF3_a-2_Smoe      -----DG-----------------------------------------------------
IRAK-Un_bo-2_Smoe  ---------------------------------------------G--------------
IRAK-Un_dc_Smoe    -----------------EV----M------EY--------PVI-----------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ---------------------------------------------G--------------
IRAK-Un_cb_Smoe    TF----------------------------------------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    SFHRRPGSSEIFPEPVED-----VPVK---ASS--L------------------------
IRAK-Un_t_Smoe     SFHRRPGSSEIFPEPVED-----VPVK---ASS--L------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  -----------------K-----M--ASNKSSS--I------------------------
IRAK-Un_bp-2_Smoe  -----------------K-----M--ASNKSSS--I------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    -----------------------S------KVK---------------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    --------------------------------------------------VKPA------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  --------------------------------------------------IHPA------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ----------------------------------------------------PA------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    --------------------------T------------------AASADDDPG------
IRAK-Un_cz_Smoe    ----------------------------------------------------PA------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    --------------------------------------------------GIP-------
IRAK-Un_br-1_Smoe  --------------------------------------------------IHPA------
IRAK-Un_av-2_Smoe  TDNELSFQVWTKQMQDVLNSRKRGDASFRDKDFKSAIDCYTQFVDVGTM-VSPTVFARRS
IRAK-Un_av-1_Smoe  TDNELSFQVWTKQMQDVLNSRKRGDASFRDKDFKSAIDCYTQFVDVGTM-VSPTVFARRS
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  --------------------------------------------------A---------
IRAK-Un_bj-1_Smoe  --------------------------------------------------A---------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  --------------------------------------------------E---------
IRAK-Un_dc_Smoe    -----------------------------------------------------A------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  --------------------------------------------------E---------
IRAK-Un_cb_Smoe    -------------------------------------------------------A-LAW
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    ---------------------------------------------------LPSIV----
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------------------------------------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  LAYLLSELPEAALRDAMQAQYVHPE---------WPTAFYLQAAA---------------
IRAK-Un_av-1_Smoe  LAYLLSELPEAALRDAMQAQYVHPE---------WPTAFYLQAAA---------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------------------------------------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    NSFLLLWTFGAP------------LPFVFFSIPFWFVGYGLSKDALSALTVTTFIE----
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    -------------------------------------------------------NFALN
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------------------------------------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------------------------------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    ------------------------------------------------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     -----------------------------LDGLDLHGVY--K------KLNK--------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    -----------------------------SDGYT----Y--EYDAIIRW-----------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    -------------------------------------------------LTKRYFSIEWK
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    HLNLVKFIGFCPRKRLPIYEFVPNGSLEKW----IFGNDRWIGWLVFK------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    --------------------H-------------REPDA---------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    --------------------F-------------RRSSS---------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    --------------------------------------------LH--------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ----ELIPRLKLLLEDQIDKH-------------RRRKDQAGDRFI--------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    --------SFS-------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    -----------------L-----------------QKSD-----AS--------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    VRNRRR-----------------------------------------IKSCCIREGVKVH
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    --------------------FRIAVGTAQGLCYLHEEC------ANKIIHLDLKLENILV
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    ------------------------------------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  ------------------------------------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ---------------------------KEARPEPLER-----------------------
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ---------------------------I-------K-AFP--------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    ------------------------------------------------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------------------------------------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------------------------------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------------------------------------------------
IRAK-Un_df_Smoe    -P-------------------------L-------EIF----------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     -P-----------------------GDF-------T-DVL--------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------------------------------------------------
IRAK-Un_bx-1_Smoe  ------------------------------------------------------------
LRR10a_d-2_Smoe    ------------------------------------------------------------
IRAK-Un_cz_Smoe    ------------------------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------------------------------------------------
IRAK-Un_br-1_Smoe  ------------------------------------------------------------
IRAK-Un_av-2_Smoe  ------------------------------------------------------------
IRAK-Un_av-1_Smoe  ------------------------------------------------------------
IRAK-Un_bx-2_Smoe  ------------------------------------------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  ------------------------------------------------------------
IRAK-Un_bj-1_Smoe  ------------------------------------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    -P-------------------------M-------T-N----------------------
IRAK-Un_k-2_Smoe   ------------------------------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    DFGGGLELVEKNWLVNEISSFLGIPP-----PPP--------------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------------------------------------------------
IRAK-Un_t_Smoe     ------------------------------------------------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------------------------------------------------
IRAK-Un_bp-2_Smoe  ------------------------------------------------------------
IRAK-Un_k-1_Smoe   ------------------------------------------------------------
IRAK-Un_bd_Smoe    DV-----------------------GFV-------P-KIADFGLSKLIARWHSIGWQNLL
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    -----------------IN------F----------------------------------
IRAK-Un_co_Smoe    ------------------------------------------------------------
IRAK-Un_ax_Smoe    ------------------------------------------------------------
IRAK-Un_br-2_Smoe  -----------------FS------T----------------------------------
IRAK-Un_bw_Smoe    ------------------------------------------------------------
IRAK-Un_ca_Smoe    ------------------------------------------------------------
IRAK-Un_am-2_Smoe  ------------------------------------------------------------
IRAK-Un_da_Smoe    ------------------A-PSAKPQQREPPDETNASSPAIRRIIQYAGGIYSYVHIALV
IRAK-Un_dg_Smoe    ------------------------------------------------------------
IRAK-Un_dj_Smoe    ------------------------------------------------------------
IRAK-Un_dm_Smoe    ------------------V------P-------F--------------------------
IRAK-Un_ag_Smoe    ------------------------------------------------------------
IRAK-Un_dq_Smoe    ------------------------------------------------------------
IRAK-Un_dh_Smoe    --------------LPSSS------T-------S--KS----------------------
IRAK-Un_dp_Smoe    ------------------------------------------------------------
IRAK-Un_bk-2_Smoe  ------------------------------------------------------------
IRAK-Un_bk-1_Smoe  ------------------------------------------------------------
IRAK-Un_ck_Smoe    ------------------------------------------------------------
IRAK-Un_cn_Smoe    ------------------------------------------------------------
IRAK-Un_bg_Smoe    ------------------------------------------------------------
IRAK-Un_cj_Smoe    ------------------------------------------------------------
IRAK-Un_v-2_Smoe   ------------------C------S-------V--DD----------------------
IRAK-Un_de_Smoe    ------------------------------------------------------------
IRAK-Un_dk_Smoe    ------------------T------D-------R--------------------------
IRAK-Un_bv_Smoe    ------------------------------------------------------------
IRAK-Un_ay-2_Smoe  ------------------------------------------------------------
IRAK-Un_ay-1_Smoe  ------------------N------D-------T--------------------------
IRAK-Un_df_Smoe    ------------------L------R-------L--P-----------------------
IRAK-Un_bt_Smoe    ------------------------------------------------------------
IRAK-Un_r_Smoe     ------------------I------S-------L--ND----------------------
IRAK-Un_bb_Smoe    ------------------------------------------------------------
IRAK-Un_v-1_Smoe   ------------------G------S-------V--DD----------------------
IRAK-Un_bx-1_Smoe  ------------------K------S-------R--------------------------
LRR10a_d-2_Smoe    -----------------AA------K----------------------------------
IRAK-Un_cz_Smoe    -----------------L------------------------------------------
IRAK-Un_e_Smoe     ------------------------------------------------------------
IRAK-Un_dn_Smoe    ------------------------------------------------------------
IRAK-Un_do_Smoe    ------------------T------A-------T--SN----------------------
IRAK-Un_br-1_Smoe  -----------------FS------T----------------------------------
IRAK-Un_av-2_Smoe  -----------------LA------K----------------------------------
IRAK-Un_av-1_Smoe  -----------------LA------K----------------------------------
IRAK-Un_bx-2_Smoe  ------------------K------S-------R--------------------------
IRAK-Un_am-1_Smoe  ------------------------------------------------------------
IRAK-Un_bj-2_Smoe  --------------DAGFS------S----------------------------------
IRAK-Un_bj-1_Smoe  --------------DAGFS------S----------------------------------
RKF3_a-2_Smoe      ------------------------------------------------------------
IRAK-Un_bo-2_Smoe  ------------------------------------------------------------
IRAK-Un_dc_Smoe    ------------------L------R-------L--E-----------------------
IRAK-Un_k-2_Smoe   ------------------S-----------------------------------------
IRAK-Un_bo-1_Smoe  ------------------------------------------------------------
IRAK-Un_cb_Smoe    ---------------------------------------VLE------------------
IRAK-Un_cs_Smoe    ------------------------------------------------------------
IRAK-Un_cu_Smoe    ------------------GSGDNNGS-------S--NN----------------------
IRAK-Un_t_Smoe     ------------------GSGDNNGS-------S--NN----------------------
IRAK-Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bp-1_Smoe  ------------------Q------I-------S--------------------------
IRAK-Un_bp-2_Smoe  ------------------Q------S-------S--------------------------
IRAK-Un_k-1_Smoe   ------------------S-----------------------------------------
IRAK-Un_bd_Smoe    YIFTHQHLHDSNTDPPALS------S-------F--SS----------------------
IRAK-Un_h_Smoe     ------------------------------------------------------------
IRAK_Un_dd_Smoe    ------------------------------------------------------------
IRAK-Un_bf_Smoe    ------------------------------------------------------------
IRAK-Un_ap-1_Smoe  ------------------------------------------------------------
IRAK-Un_ap-2_Smoe  ------------------------------------------------------------


IRAK-Un_aw_Smoe    --------------LGLDFFF----I--AFVF---Q---R-FS------TSSVEHGSRS
IRAK-Un_co_Smoe    --------------------------------------------------YVEYTRNTC
IRAK-Un_ax_Smoe    ----------------------------------------------------GLASSLI
IRAK-Un_br-2_Smoe  --------------VNGTHVQ----K--KIVT---R---I-IK------TLCSSPGTFD
IRAK-Un_bw_Smoe    -------------------------------------------------------EVAT
IRAK-Un_ca_Smoe    -------------------------------------------------EGAAGNGGYL
IRAK-Un_am-2_Smoe  ---------------------------------------------------DTAEVYKF
IRAK-Un_da_Smoe    RWRPRGR--------------S----T---SR-QWK-----SP------VNFHMRGDSE
IRAK-Un_dg_Smoe    ------------------------------VS---S---P----------VTLRGLMEG
IRAK-Un_dj_Smoe    ----------------------------------------------------LALAGQG
IRAK-Un_dm_Smoe    --------------------------D---PS---P-----AF------SETLDSPHPR
IRAK-Un_ag_Smoe    ------------------H-E--FF-----------SGRASSI------DAWLNAGSRK
IRAK-Un_dq_Smoe    ------------------H-E--FF-----------SGRASSI------DAWLNAGSRK
IRAK-Un_dh_Smoe    ------S--------------KF---S---FS---------SV------DETSTLVFIN
IRAK-Un_dp_Smoe    -------------------------------------------------------AEEP
IRAK-Un_bk-2_Smoe  -------------------------------------------------EGQQHHQHHS
IRAK-Un_bk-1_Smoe  -------------------------------------------------EGQQHHQHHS
IRAK-Un_ck_Smoe    -----------------------------------------------------NTASNS
IRAK-Un_cn_Smoe    ---------------------------------------K--K------QRPPPGKSRD
IRAK-Un_bg_Smoe    ------------------------------------------------------AGFGV
IRAK-Un_cj_Smoe    -----------------------------------------------------NTASNS
IRAK-Un_v-2_Smoe   ------G--------------D-------------F-----AF------LFFQSLLTPR
IRAK-Un_de_Smoe    ---------------------------------------------------KHSISMVI
IRAK-Un_dk_Smoe    ------A--------------D----Q---QS---E-----KI------SLPSDDMMER
IRAK-Un_bv_Smoe    ----------------------------------------------------------L
IRAK-Un_ay-2_Smoe  ---------------------------------------------------NSEQTSIS
IRAK-Un_ay-1_Smoe  -----------------------------------H-----TP------FIETKSAKDN
IRAK-Un_df_Smoe    ---------------------------GGDGI---------PC------DRVGRIHVRV
IRAK-Un_bt_Smoe    -----------------------------------------K-------NHHIFLPGMH
IRAK-Un_r_Smoe     ------K-D------------N---LS---NL---S-----IL------ALLSVSFINI
IRAK-Un_bb_Smoe    ---------------------------------------------------------TM
IRAK-Un_v-1_Smoe   ------C--------------D-------------F-----AF------LFFQSLLTPR
IRAK-Un_bx-1_Smoe  ------R--------------K----A---SA---E---------------HVAVDMPS
LRR10a_d-2_Smoe    ------------------------------AS---S---S-EQ------TGVQMQRLNA
IRAK-Un_cz_Smoe    -----------------------------------------IT------VQSEIMESLF
IRAK-Un_e_Smoe     ------------------------------------------F------LDSGEVTSRV
IRAK-Un_dn_Smoe    ------R--------------T----S---SS---T-----GN------RCSIEVFSAR
IRAK-Un_do_Smoe    ------A-KNLFLFSTSPHAPS-------------FSSY--ST------YSPSYSLRFS
IRAK-Un_br-1_Smoe  --------------VNGTHVQ----K--KIVT---R---I-IK------TLCSSPGTFD
IRAK-Un_av-2_Smoe  --------------L-GMETD----A--KDML---K---E-GA------AMDMKRQNLS
IRAK-Un_av-1_Smoe  --------------L-GMETD----A--KDML---K---E-GA------AMDMKRQNLS
IRAK-Un_bx-2_Smoe  ------R--------------K----A---SA---E---------------HVAVDMPS
IRAK-Un_am-1_Smoe  ---------------------------------------------------DTAEVYKF
IRAK-Un_bj-2_Smoe  --------------S-GEECT--SY-----------PTRQ-QA------AYAEMLDYGR
IRAK-Un_bj-1_Smoe  --------------S-GEECP--SY-----------PTRQ-QA------AYAEMLDYGR
RKF3_a-2_Smoe      ------E--------------EV---N---LF------------------SSSSQTSAP
IRAK-Un_bo-2_Smoe  ---------------------------------------G-AT------VVTLGSELFK
IRAK-Un_dc_Smoe    ------N-K------------N---LTPNRVV---R-----SA------ICEWRAPKLP
IRAK-Un_k-2_Smoe   --------------------------T---SS---Q-----SN------AQLRGLVSGR
IRAK-Un_bo-1_Smoe  ---------------------------------------G-PT------VVTLGSELFK
IRAK-Un_cb_Smoe    ------------------E-T--FV-----------DNRAWDRERDFWGRDRDFHDDFW
IRAK-Un_cs_Smoe    ------------------------------------------------------MNGSV
IRAK-Un_cu_Smoe    ------NSV------------KL---R---QYQQQQ-----QQ------QQSWYLNPDR
IRAK-Un_t_Smoe     ------NSV------------KL---R---QY------------------QQQQQQQQV
IRAK-Un_dd_Smoe    ----------------------------------------------------SVTLERS
IRAK-Un_bp-1_Smoe  ------R--------------S----P---SS---V-----TS------NSNLPMNQPR
IRAK-Un_bp-2_Smoe  ------R--------------S----P---SS---V-----TS------NSNMPMNQPR
IRAK-Un_k-1_Smoe   --------------------------T---SS---Q-----SN------AQLRGLVSGR
IRAK-Un_bd_Smoe    ------R--------------MLSETS---NS---Q-----AQ------ATSKNHRKPH
IRAK-Un_h_Smoe     -------------------------------------------------RPMEELLRDG
IRAK_Un_dd_Smoe    --------------------------------------------------------CRL
IRAK-Un_bf_Smoe    -------------------------------------------------KHAALSKVTS
IRAK-Un_ap-1_Smoe  -------------------------------------------------LEESKSFTET
IRAK-Un_ap-2_Smoe  -------------------------------------------------LEQSKSLTKT