IRAKj_c-2_Smoe MRGKNAGSSSCGSPALGILTAMSIGIGRWIVLGVV---VIAGAAAAVDPTERAVLDAMIQ
IRAKj_a-2_Smoe MKLKKK-----------------HPAALLLLL---VASVLAMALAQTDSAELQVLQNFLK
IRAKj_a-1_Smoe MKLKKK-----------------HPAALLLLL---VASILAMALAQTDSAELQVLQNFLK
IRAKj_d-2_Smoe MERFRAGAMAAA----------RNPWKKLLLLVLLLVSLHWRCSATTNPGDLAVLQSFLQ
IRAKj_b-1_Smoe MEQHS--------------------WKYFLLLGVL----LVSAAAETDPVDAEALQSFQK
IRAKj_d-1_Smoe MERFRAGAMAGA----------RNLWKKLLLLALLLVSLHWRCTATTNPGDLAVLQSFLQ
IRAKj_b-2_Smoe MEQHS--------------------WKYFLLLGVL----LVSAAAETDPVDAEALQSFQK
IRAKj_c-1_Smoe MRGKNAGSSPRGSPALGILTAMSIGIGRWIVLGVV---IIAGAAAAVDPTERAVLDAMIQ
*. ::* . * .:. : .*: : :
IRAKj_c-2_Smoe GLTNGALL-GWGSGDPC--SWKHIQCRGQSIIGIAVESLGLVGTLPGNLNKLANLEYLGL
IRAKj_a-2_Smoe GVKNPALLDSWTGSDPCGSNWKHIKCQGSSISALQVAGLALGGTVAPDLNKLKNLENLQL
IRAKj_a-1_Smoe GVKNPALLDSWTGSDPCGSNWKHIKCQGSSISALQVAGLALGGTVAPDLNKLKNLENLQL
IRAKj_d-2_Smoe GIDQKSVLTNWKNSDPCGDRWIHIKCTGAAVTALEMNNLQLGGTVTPDINKLSSLDSLQL
IRAKj_b-1_Smoe GLSNGEIL-QWSGTDPCGAAWKHVQCRGKSVTGIDVAFLGLQGIVSPSLNRLSNLEYLGM
IRAKj_d-1_Smoe GIDQKSVLTNWKNSDPCGDRWIHIKCTGAAVTALEMNNLQLGGTVTPDINKLSSLDSLQL
IRAKj_b-2_Smoe GLSNGEIL-QWSGTDPCGAAWKHVQCRGKSVTGIDVAFLGLQGIVSPSLNRLSNLEYLGM
IRAKj_c-1_Smoe GLTNGALL-GWGSGDPC--SWKHIQCRGQSIIGIAVESLGLVGTLPGNLNKLANLEYLGL
*: : :* * . *** * *::* * :: .: : * * * :. .:*:* .*: * :
IRAKj_c-2_Smoe QFNGFHGALPSLSGLKNLRTVYLNSNNFATIPGDFFRGLDSLMVIYLDHNNLNGT-AGWQ
IRAKj_a-2_Smoe QGNGFTGSLPSLSGLSQLQTALLSGNSFDTIPGDFFTGLSALTEIYLDDNPLNKSSGGWM
IRAKj_a-1_Smoe QGNGFTGSLPSLSGLSQLQTALLSGNSFDTIPGDFFTGLSALTEIYLDDNPLNKSSGGWM
IRAKj_d-2_Smoe QQNGFTGSLPSLSGLTSLSRAYFGGNSFDTIPGDFFTGLTNVMEIFLEDNHVNST-QGWS
IRAKj_b-1_Smoe QGNALSGSMPSLAGMANLKIAYFDNNDFSSIPGDFFAGLESLEAIYLDNNPLNGT-AGWE
IRAKj_d-1_Smoe QQNGFTGSLPSLSGLTSLSRAYFGGNSFDTIPGDFFTGLTNVMEIFLEDNHVNST-PGWS
IRAKj_b-2_Smoe QGNALSGSMPSLAGMANLKIAYFDNNDFSSIPGDFFAGLESLAAIYLDNNPLNGT-AGWE
IRAKj_c-1_Smoe QFNGFHGALPSLSGLKNLRKVYLNSNNFATIPGDFFRGLDSLMVIYLDHNNLNGT-AGWQ
* *.: *::***:*: .* . :..*.* :****** ** : *:*:.* :* : **
IRAKj_c-2_Smoe LPDDVQFSTKLVNLSLTNTSLGGPIPEFLGTMASLKVLNLAYNSLTGGLPASFKDSAMTQ
IRAKj_a-2_Smoe LPAEIQNSSLLSTLSITNTSLGGSIPGFLGQMESLKVLNVAYNRISGGIPSSFGSSNLAE
IRAKj_a-1_Smoe LPAEIQNSSLLSTLSITNTSLGGSIPDFLGQMESLKVLNVAYNRISGGIPSSFGSSNLAE
IRAKj_d-2_Smoe LPADIQHCSNLQTLSITNTTLGGTIPGFLGTMSSLKNLYLAYNTLRGGIPATFAGSNLIK
IRAKj_b-1_Smoe LPVDISHLGALANLSLTNSSVVGSIPAFLGAMPHLKVLNLAYNRLTGGIPPSFVSSNLVQ
IRAKj_d-1_Smoe LPADIQHCSNLQTLSITNTTLGGTIPDFLGTMSSLKNLYLAYNTLRGGIPATFAGSNLIK
IRAKj_b-2_Smoe LPVDISHLGALANLSLTNSSVVGSIPAFLGAMPQLKVLNLAYNRLTGGIPPSFVSSNLVQ
IRAKj_c-1_Smoe LPDDVQFSTKLVNLSLTNTSLGGPIPEFLGTMASLKVLNLAYNSLTGGLPASFKDSAMTQ
** ::. * .**:**::: *.** *** * ** * :*** : **:*.:* .* : :
IRAKj_c-2_Smoe LEVNNM----ALGGSIDVVGGMTSLAQLWLQGNQFTGTIPVGLSNAVAMADLRLNDNKLK
IRAKj_a-2_Smoe FRANNQQN-PVLSGPITVVGTMQSLRVLWLHVNRFSGSIPDGLGEALSLQELKLNDNQLT
IRAKj_a-1_Smoe FRANNQQN-PVLSGPITVVGTMQSLRVLWLHVNRFSGSIPEGLGEALSLQELKLNDNQLT
IRAKj_d-2_Smoe FQANNQQGNEPLTGSIDPVASMQSLTTLWLHVNQFSGVIPPGLGNLSSLQDLKLNDNEFV
IRAKj_b-1_Smoe LQANNMQG-PVLTGPIDAVGGMGSLVQLWLQVNEIAGTIPPGLGNALALQDLKLNDNRLT
IRAKj_d-1_Smoe FQANNQQGNEPLTGSIDPVASMQSLTTLWLHVNQFSGVIPPGLGNLSSLQDLKLNDNEFV
IRAKj_b-2_Smoe LQANNMQG-PVLTGPIDAVGGMGSLVQLWLQVNEIAGTIPRGLGNALALQDLKLNDNRLT
IRAKj_c-1_Smoe LEVNNM----ALGGSIDVVGGMTSLAQLWLQGNQFTGTIPVGLSNAVAMADLRLNDNKLK
:..** * *.* *. * ** ***: *.::* ** **.: :: :*:****.:
IRAKj_c-2_Smoe GVVPN-FTALP-LSHFSVTNNNLMGPIPLLRATNTDGFGGNKFCQSEAGKACSAEVTALL
IRAKj_a-2_Smoe GTIPPSLANLPALKNFTVKNNLLVGEIPVFKDTVGFEYARNNFCKSSPGEACARDVTALL
IRAKj_a-1_Smoe GTIPPSLANLPALKNFTVKNNLLVGEIPVFKDTVGFEYARNNFCKSSPGEACARDVTALL
IRAKj_d-2_Smoe GVVPQSLTQLPALKNFTIKGNMLVGPMPELGFS--YDGSTNGFCQATPGLPCDPRVTALL
IRAKj_b-1_Smoe GPIPASLAELP-LAILSVDNNELIGVLPAFKPATKVLATGNNFCQAVPGLRCSHDVETLL
IRAKj_d-1_Smoe GVVPQSLTQLPALKNFTIKGNMLVGPMPELGFS--YDGSTNGFCQATPGLPCDPRVTALL
IRAKj_b-2_Smoe GPIPASLAELP-LAILSVDNNELIGVLPAFKPTTKVLATGNNFCQAVPGLRCSHDVETLL
IRAKj_c-1_Smoe GVVPN-FTALA-LSHFSVTNNNLMGPIPLLRATNTDGFGGNKFCQSEAGKACSAEVTALL
* :* :: *. * ::: .* *:* :* : : * **:: .* * * :**
IRAKj_c-2_Smoe GFLGGI-GFPDSIIADWSGTDPCA-----------VTWVVCDRT-----AVIGLKLERNQ
IRAKj_a-2_Smoe HFLAGV-GYPDSLTSSWIGNDPCGTSGSNGSSGSAWLGISCGSTPGTTSNVTVINLASSQ
IRAKj_a-1_Smoe HFLAGV-GYPDSLTSSWIGNDPCGTSGSNGSSGSAWLGISCGSTPGTTSNVTVINLASSQ
IRAKj_d-2_Smoe DFAGAADAFTSPCMTTWKGNDPCS-----------WTGINCVR-----GTVTTIQLPNCQ
IRAKj_b-1_Smoe EFIGEF-GYPASIVSSWKGDDPCL-----------WTGIVCDSG----KRVSVIDLAGSQ
IRAKj_d-1_Smoe DFAGAADAFTSPCMTTWKGNDPCS-----------WTGINCVR-----GTVTTIQLPNCQ
IRAKj_b-2_Smoe EFIGEF-GYPASIVSSWKGDDPCL-----------WTGIVCDSG----KRVSVIDLAGSQ
IRAKj_c-1_Smoe GFLGGI-GFPDSIIADWSGTDPCA-----------VTWVVCDGT-----AVIGLKLERNQ
* . .:. . : * * *** : * * :.* *
IRAKj_c-2_Smoe LAGTLSPAVAGLADLRFVMLSNNNLSGSIPPEFATMKSLKTLDLRNNSLSGPMVKF-SGV
IRAKj_a-2_Smoe LNGTLSAALGNLTTLTTLRLSDNKLEGLIPESLAKLPSLQSVDLSNNLFSAPVPAFPSSV
IRAKj_a-1_Smoe LNGTLSAALGNLTTLTTLRLSDNKLEGLIPESLAKLPSLQSVDLSNNLFSAPVPAFPSSV
IRAKj_d-2_Smoe LNGSISTALANLTGLTALDLRNNHISGLLPAAIVQIPTLRNLNLFRNRLSGPLPPFPSGL
IRAKj_b-1_Smoe LVGRLSPALVNLTALTVLRLNGNNISGGIPPVLTSMKSLQQVDLHNNNLSGDLPQFPESV
IRAKj_d-1_Smoe LNGSISTALANLTGLTALDLRNNHISGLLPAAIVQIPTLRNLNLFRNRLSGPLPPFPSGL
IRAKj_b-2_Smoe LVGRLSPALVNLTALTVLRLNGNNISGGIPPVLTSMKSLQQVDLHNNNLSGDLPQFPESV
IRAKj_c-1_Smoe LAGTLSPAVAGLADLRFVMLSNNNLSGSIPPEFATMKSLKTLDLRNNSLSGPMVKF-SGV
* * :*.*: .*: * : * .*::.* :* :. : :*: ::* .* :*. : * ..:
IRAKj_c-2_Smoe TVLVDGNPLLN-TAPAGSAP--A----------------TTPSPPSPPGTPPPPGTQDDS
IRAKj_a-2_Smoe KLNIAGNPLTP-AA----SP------GTSP--PGGTSGG-------PAATPDGQATATT-
IRAKj_a-1_Smoe KLNIAGNPLTP-AA----SP------GTSP--PGGTSGG-------PAATPDGQATATT-
IRAKj_d-2_Smoe QVNVDENPLTP-VSP-ASGS------GASP---SGSSGT------QAPGSPNAPSGAEQ-
IRAKj_b-1_Smoe KTNFQGNPLLLQSLPPVTSP------PVAPAQPSGSSGGGGG-------AKNTNTTVANN
IRAKj_d-1_Smoe QVNVDENPLTP-VSP-ASGS------GASP---SGSSGT------QAPGSPNAPSGAEQ-
IRAKj_b-2_Smoe KTNFQGNPLLLQSLPPVTSP------PVTPAQPSGSSGGGGG-------AKNTNTTVANN
IRAKj_c-1_Smoe TVLVDGNPLLN-SPP-GSAPVPPSSSPAAPAAPAGSAPATTPSPPSPPGTPPPPGTQDDS
. *** .. :
IRAKj_c-2_Smoe GNRTRPN-SPQASS-KFPIVGVAVPIAGVVSLALVAGVFIFFLCCRHKGKHQASRSSSSG
IRAKj_a-2_Smoe ---R---------SKRVNAGPIVGVVVGLVALL-LVLFGICLLVYKKKGRKFLRLQGSNT
IRAKj_a-1_Smoe ---R---------SKRVNAGPIVGVVVGLVALL-LVLFGICLLVYKKKGRKFLRLQGSNT
IRAKj_d-2_Smoe --ST---------RRKVSPAAVAVPVVGAVAAV-AAAVSV-FVMCRRKRPRFMRVQSSSA
IRAKj_b-1_Smoe --ATAAEVLPRSHHNSVKAGLIAGPVVGAVSLL-AIGLALSFLFYKRSEKRFVRVQG-PT
IRAKj_d-1_Smoe --ST---------RRKVSPAAIAVPVVGAVAAV-AAAVSV-FVMCRRKRPRFMRVQSSSA
IRAKj_b-2_Smoe --ATAAEVLPRSQHNSVKAGLIAGPVVGAVSLL-AIGLALSFLFYKRSEKRFVRVQG-PT
IRAKj_c-1_Smoe GNR--TN-SPQASS-KFPIVAVAVPIAGAVSLALVAGVFIFFLCCRHKGKHQASRSSSSG
. :. :.* *: . : :: ::. : ..
IRAKj_c-2_Smoe MLVHPRN--SNSDPDMVKVSVTRTA---------EPNGGGNHSGPSGDVHVVEAGNLVIS
IRAKj_a-2_Smoe VVVHPRTDNSSDDPEVVKIVVNNNMITS----DNSDTQSRANSGPSDHVQVVEAGNLVIS
IRAKj_a-1_Smoe VVVHPRTDNSSDDPEVVKIVVNNNMITS----DNSDTQSRANSGPSDHVQVVEAGNLVIS
IRAKj_d-2_Smoe IVVHPRD--SSFERETVKLPTS--------------VAKEGHSGPSE-V-RVETGNLVIS
IRAKj_b-1_Smoe MVVHPRD--SSSE-DIVKIIVPGGAGNNVNSRSLVETAS-VNSNGT-DVQVVEAGNLVIS
IRAKj_d-1_Smoe IVVHPRD--SSFERETVKLPTS--------------VAKEGHSGPSE-V-RVETGNLVIS
IRAKj_b-2_Smoe MVVHPRD--SSSE-DIVKIIVPGGAGNNVNSRSLVETAS-VNSNGT-DVQVVEAGNLVIS
IRAKj_c-1_Smoe MLVHPRN--SNSDPDMVKVSVTRTA---------EPNGGGNHSGPSGDVHVVEAGNLVIS
::**** *. : : **: . :*. : * **:******
IRAKj_c-2_Smoe IQVLRDATKNFSRDTILGRGGFGVVYKGVLDDGTSIAVKRMEASTVVSSKGLSEFHAEIA
IRAKj_a-2_Smoe IHVLREATKNFSEATILGRGGFGVVYKGVLDDGTAIAVKRMESNCVVSNKGLGEFQAEIA
IRAKj_a-1_Smoe IHVLREATKNFSEATILGRGGFGVVYKGVLDDGTAIAVKRMESNCVVSNKGLGEFQAEIA
IRAKj_d-2_Smoe IHVLRKATNGFSENSILGRGGFGVVYKGELDDGTKIAVKRMES-AVVNNKGLSEFQAEIQ
IRAKj_b-1_Smoe IHVLRNATRNFSEETVLGRGGFGAVYRGQLDDGTNIAVKRMEASSVVSSKGVSEFHAEIA
IRAKj_d-1_Smoe IHVLRKATNGFSENSILGRGGFGVVYKGELDDGTKIAVKRMES-AVVNNKGLSEFQAEIQ
IRAKj_b-2_Smoe IHVLRNATRNFSEETVLGRGGFGAVYRGQLDDGTNIAVKRMEASSVVSSKGVSEFHAEIA
IRAKj_c-1_Smoe IQVLRDATKNFSRDTILGRGGFGVVYKGVLDDGTSIAVKRMEASTVVSSKGLSEFHAEIA
*:***.**..**. ::*******.**:* ***** *******: **..**:.**:***
IRAKj_c-2_Smoe VLTKVRHRHLVALLGYCIEGNEKLLVYEYLPNGTLAQHLFER---GAKPLDWKRRLVIAL
IRAKj_a-2_Smoe VLTKVRHRHLVALLGYCIEGNEKMLVYEFMPQGTLSQHLFEAAKCGYPPLDWKQRLSVAL
IRAKj_a-1_Smoe VLTKVRHRHLVALLGYCIEGNEKMLVYEFMPQGTLSQHLFEAAKCGYPPLDWKQRLSVAL
IRAKj_d-2_Smoe VLTKVRHRHLVALLGYCIDGNEKLLVYEYMPQGTLSQHLFEFAKHGYHHLTWKHRLSIAL
IRAKj_b-1_Smoe VLSKVRHRHLVALLGYCIDGNEKLLVYEYLPQGALSHHLFEYRRMRLKPLEWKRRLAIAL
IRAKj_d-1_Smoe VLTKVRHRHLVALLGYCIHGNEKLLVYEYMPQGTLSQHLFEFAKHGYHHLTWKHRLSIAL
IRAKj_b-2_Smoe VLSKVRHRHLVALLGYCIDGNEKLLVYEYLPQGALSHHLFEYRRMRLKPLEWKRRLAIAL
IRAKj_c-1_Smoe VLTKVRHRHLVALLGYCIEGNEKLLVYEYLPNGTLAQHLFER---GAKPLDWKRRLVIAL
**:***************.****:****::*:*:*::**** * **:** :**
IRAKj_c-2_Smoe DVARGMEYLHELAHRSFIHRDLKPSNILLDDDYRAKVSDFGLVKLAPEGKYSIETRLAGT
IRAKj_a-2_Smoe DVARGMEYLHGLAHRSFIHRDLKPSNILLGDDLRAKVSDFGLVKLAPEGKYSVETRLAGT
IRAKj_a-1_Smoe DVARGMEYLHGLAHRSFIHRDLKPSNILLGDDLRAKVSDFGLVKLAPEGKYSVETRLAGT
IRAKj_d-2_Smoe DVARGIEYLHGLAHKSFIHRDLKPSNILLDDTLHAKVADFGLVKLAPEGKVSVETRLAGT
IRAKj_b-1_Smoe DVARGMEYLHGLAYKSFIHRDLKPSNILLDDDLRAKVADFGLVKLAPEGKYSVETRLAGT
IRAKj_d-1_Smoe DVARGIEYLHGLAHKSFIHRDLKPSNILLDDTLHAKVADFGLVKLAPEGKVSVETRLAGT
IRAKj_b-2_Smoe DVARGMEYLHGLAYKSFIHRDLKPSNILLDDDLRAKVADFGLVKLAPEGKYSVETRLAGT
IRAKj_c-1_Smoe DVARGMEYLHELAHMSFIHRDLKPSNILLDDDYRAKVSDFGLVKLAPEGKYSIETRLAGT
*****:**** **: **************.* :***:************ *:*******
IRAKj_c-2_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLMELITGRRALDESQSEENMHLVTWFRRTH--QG
IRAKj_a-2_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLMELITGRRALDETQAEENMHLVTWFRRST--AN
IRAKj_a-1_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLMELITGRRALDETQAEENMHLVTWFRRST--AN
IRAKj_d-2_Smoe FGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRQALDTSRSEETMHLPTWFKRMR--VN
IRAKj_b-1_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLLELISGRRALDESQPEENMHLVTWYRRITSSSS
IRAKj_d-1_Smoe FGYLAPEYAVTGRVTTKVDVYSFGVILMELITGRQALDTSRSEETMHLPTWFKRMR--VN
IRAKj_b-2_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLLELISGRRALDESQPEENMHLVTWYRRITSSSS
IRAKj_c-1_Smoe FGYLAPEYAVTGRVTTKADVFSFGVVLMELITGRRALDESQSEENMHLVTWFRRTH--QG
*****************.**:****:*:***:**:*** ::.**.*** **::* .
IRAKj_c-2_Smoe RESFARMIDPALLE--GTEDKVEGIYTVAELAKHCTAREPYNRPDMGHAVSVLAPLVEQW
IRAKj_a-2_Smoe KEGVRKLIDPAIE----SDDNFASISVVAELAGHCTAREPYQRPDMGHAVNVLSPLVEHW
IRAKj_a-1_Smoe KEGVRKLIDPAIE----SDDNFASISVVAELAGHCTAREPYQRPDMGHAVNVLSPLVEHW
IRAKj_d-2_Smoe RETFRSSLDPVLE---VTDEEFESICSVAELAGYCTMREPYQRPDMSHAVNVLAPMVERW
IRAKj_b-1_Smoe KESLLRIIDPVLGVGDVTGDVFHSVYTVSELARHCTAREPYQRPDMGHAVSVLSPLVDQW
IRAKj_d-1_Smoe RETFRSSLDPVLE---VTDEEFESICSVAELAGYCTMREPYQRPDMSHAVNVLAPMVERW
IRAKj_b-2_Smoe KESLLRIIDPVLG----VGDVFHSVYTVSELARHCTAREPYQRPDMGHAVSVLSPLVDQW
IRAKj_c-1_Smoe RESFARMIDTALLE--GTEDKVEGIYTVAELAKHCTAREPYNRPDMGHAVSVLAPLVEQW
:* . :*..: : . .: *:*** :** ****:****.***.**:*:*::*
IRAKj_c-2_Smoe KPTASDGEETKGIDLNVSLPQALKQWQASDDSN---------L--DDSQASIPTRPVGFA
IRAKj_a-2_Smoe KPV-DYEDESGGIDLDVPLPQAVKRWQELDSGGGGGGAA-AVW--SDTQSSLPPRPSGFA
IRAKj_a-1_Smoe KPV-DYEDESGGIDLDVPLPQAVKRWQELDSGGGGGGAA-AVW--SDTQSSLPPRPSGFA
IRAKj_d-2_Smoe KPSMDFDAEEGGIDLGLSLSEALRRWQESETG----------M--DETRTSLPTRPPGFA
IRAKj_b-1_Smoe KPADQDGEESAGIDLSLTLPQALKKWQASEEDSSSGAASRRMLDDYDSHDSLPTRPAGFA
IRAKj_d-1_Smoe KPSMDFDAEEGGIDLGLSLSEALRRWQESETG----------M--DETRTSLPTRPPGFA
IRAKj_b-2_Smoe KPADQDGEESAGIDLSLTLPQALKKWQAYEEDSSSGAASRRMLDDYDSHDSLPTRPAGFA
IRAKj_c-1_Smoe KPTASDGEETKGIDLNVTLPQALKQWQASDDSN---------L--DDSQASLPTRPVGFA
** . * ****.:.*.:*:::** : . ::: *:*.** ***
IRAKj_c-2_Smoe DSFTSSDAR
IRAKj_a-2_Smoe ETFTSEDAR
IRAKj_a-1_Smoe ETFTSEDAR
IRAKj_d-2_Smoe DSFSSTDVR
IRAKj_b-1_Smoe EAFTAADGR
IRAKj_d-1_Smoe DSFSSTDVR
IRAKj_b-2_Smoe EAFTAADGR
IRAKj_c-1_Smoe DSFTSSDAR
::*:: * *