IRAKk_c-1_Smoe  MRRIL---------------------------------------------------VELA
IRAKk_g_Smoe    ------------------------------------------------------------
IRAKk_e-2_Smoe  C------------------------------CMDNMMNRPGGETCSCVYPIEIGLLLDNV
IRAKk_b-2_Smoe  MDTYI-------------------------------------------------------
IRAKk_c-2_Smoe  MRRVL---------------------------------------------------VELA
IRAKk_b-1_Smoe  MDTYI-------------------------------------------------------
IRAKk_a-1_Smoe  MLMN------------------------------------------------------HS
IRAKk_a-2_Smoe  MLMN------------------------------------------------------HS
IRAKk_e-1_Smoe  HPG---------------------------CCVDNMMNRPGGETCSCVYPIEIGLLLDNV
IRAKk_f_Smoe    ------------------------------------------------------------
IRAKk_d_Smoe    MVFPSPPNAGIFFFLLRVCVSRSFYAGCDKVCSDPSVTTLPGTKCGCVIPMRVGLALEIP


IRAKk_c-1_Smoe  GDNTS-----------------------------EDN-----------------------
IRAKk_g_Smoe    ------------------------------------------------------------
IRAKk_e-2_Smoe  SSNFINSTVAFQHQLASQLKLQDPQVVITAFYYIS--TSELNMSIYLGPLVGVSFSSEEA
IRAKk_b-2_Smoe  ------------------------------------------------------------
IRAKk_c-2_Smoe  GDNTS-----------------------------EDN-----------------------
IRAKk_b-1_Smoe  ------------------------------------------------------------
IRAKk_a-1_Smoe  SNNSY-----------------------------SSP-----------------------
IRAKk_a-2_Smoe  SNNSY-----------------------------SSP-----------------------
IRAKk_e-1_Smoe  SSNFINSTVAFQHQLASQLKLQDPQVVITAFYYIT--TSELNMSIYLGPLVGVSFSSQEA
IRAKk_f_Smoe    ------------------------------------------------------------
IRAKk_d_Smoe    ISSFLSLVSELAMEIAFGISMQQMQVQIAAANSFGEDFSLTETKVNLVPL-GNAFRNQTA


IRAKk_c-1_Smoe  -----------------------------------LVLIIAIIIASAALV--LVAIAF-A
IRAKk_g_Smoe    ------------------------------------------------------------
IRAKk_e-2_Smoe  TSVKASLDAHKVRFNSSLVGNYTLLRFNLFGPEPVSP-SPSPVFAPSPSR--NQPLSTPT
IRAKk_b-2_Smoe  ------------------------------------------------------------
IRAKk_c-2_Smoe  -----------------------------------LVLIIAIIIASAALV--LVAIAF-A
IRAKk_b-1_Smoe  ------------------------------------------------------------
IRAKk_a-1_Smoe  -----------------------------------SP-TPRPVLPPPSLL--TLQISPPP
IRAKk_a-2_Smoe  -----------------------------------SP-TPRPVLPPPSLL--TLQISPPP
IRAKk_e-1_Smoe  TSVKASLDAHKVRFNSSLVGNYTLLRFNLFGPEPVSP-SPSPVFAPSPSR--NQPLSTPT
IRAKk_f_Smoe    ------------------------------------------------------------
IRAKk_d_Smoe    YHISQMFWGHRVPINEAYFVNYTVLYV-IYPGLPLAS-QNVNRIPPSDGKFPDQPLGVDI


IRAKk_c-1_Smoe  YYC--------------------------------------YLRHKARAPRQEVAEQAK-
IRAKk_g_Smoe    ------------------------------------------------------------
IRAKk_e-2_Smoe  NNQSSASERPKGKVRLGIILGVGIAI-VALLCLSILF-----IR--KLAPGNKESEEKA-
IRAKk_b-2_Smoe  -----------------------------------------------RSERDE-------
IRAKk_c-2_Smoe  YYC--------------------------------------YLRHKARAPRQE-------
IRAKk_b-1_Smoe  -----------------------------------------------RSEREE-------
IRAKk_a-1_Smoe  NNC----------------------------------------SGAGGEERDHI------
IRAKk_a-2_Smoe  NNC----------------------------------------SGAGGEERDHI------
IRAKk_e-1_Smoe  NNQSSASERPKGKVRLGIILGVGIAI-VALLCLSILF-----IR--KLAPGNKESEEKA-
IRAKk_f_Smoe    ------------------------------------------------------------
IRAKk_d_Smoe    FARRNRNLHPA-------FIAIITLSCVFLLILCLGVGWLITVRHRGRYKGHSELTEAAL


IRAKk_c-1_Smoe  -SVTSQ------SISLS-----RRS-SYN-GSTSEAQVFTYKQMQAATNNFTTSNEVGQG
IRAKk_g_Smoe    -------------------------------------VMDYKMLESATDRFSEENLIGEG
IRAKk_e-2_Smoe  -SLTKS-----------ASDPPQML-SLL-TRPTSTRIFSYEDLKEATNGFDPANLLGEG
IRAKk_b-2_Smoe  --------------------------------VSKAQVFTYKQLQSATNNFSPLNKIGHG
IRAKk_c-2_Smoe  ------------------------G-TYN-GSTSEAQVFTYKQMQAATNNFTTSNEVGQG
IRAKk_b-1_Smoe  --------------------------------VSKAQVFTYKQLQSATNNFSPLNKIGHG
IRAKk_a-1_Smoe  ----------------------------A-IKRPGPQPFSFHQLQIATNSFSERNIIGRG
IRAKk_a-2_Smoe  ----------------------------A-IKRPGPQPFSLHQLQIATNSFSERNIIGRG
IRAKk_e-1_Smoe  -SLTKS-----------ASDPPQML-SLL-TRPTSTRIFSYEDLKEATNGFDPANLLGEG
IRAKk_f_Smoe    -------------------------------------M----------------------
IRAKk_d_Smoe    ESCATKRSTTATLLSNSSRDSTSVSSSIVPYVSGSVRTFTLAEMTAATNNFNPSNVIGQG


IRAKk_c-1_Smoe  GFGSVFRGVLPDGRTAAIKQLDRGGKQGDREFRVEVDMLSRLHSPHLLELIGYCAD--QE
IRAKk_g_Smoe    GFARVYKAQLDDDHAIAVKKLSTENDQADEEFRAEINLMGRIHHPNLIALLGFSSQ--GE
IRAKk_e-2_Smoe  GFGRVYRGNLKDGMAVAIKRLSSGGHQGDKEFLVEVEMLSRLHHRHLVKLVGFFSSRDSS
IRAKk_b-2_Smoe  GFGLVYRGVLPDGRLAAVKLMDRQGKQGEREFRVEVDMLTRLHSPYLLDLIGYCAD--KD
IRAKk_c-2_Smoe  GFGSVFRGVLPDGRTAAIKQLDRGGKQGDREFRVEVDMLSRLHSPHLLELIGYCAD--QE
IRAKk_b-1_Smoe  GFGLVYRGVLPDGRLAAVKLMDRQGKQGEREFRVEVDMLTRLHSPYLLDLIGYCAD--KD
IRAKk_a-1_Smoe  GFGCVYRGILADGRVAAIKKLDLEGKQGEEEFRVEIEMLSRVQAPKLLELLGYCTE--DE
IRAKk_a-2_Smoe  GFGCVYRGILADGRVAAVKKLDLEGKQGEEEFCVEIEMLSRVQAPKLLELLGYCTE--NE
IRAKk_e-1_Smoe  GFGRVYRGNLKDGMAVAIKRLSSGGHQGDKEFLVEVEMLSRLHHRHLVKLVGFFSSRDSS
IRAKk_f_Smoe    ---------------VAVTLF--------AFFQAEINLMGRIHHPNLIALLGFSSQ--GE
IRAKk_d_Smoe    GFGRVYSGVLTDGTKIAVKVLIREDKQGDREFSAEVEMLSRLHHRNLVKLVGICTD--DD
                                *:. :          * .*:::: *::   *: *:*  :.   .

IRAKk_c-1_Smoe  HRLLVYEFMPNGSVQEHLHSDGTSGRPPMLDWDTRMRVALDAARGLEYLHEMVSPPIIHR
IRAKk_g_Smoe    DRLLIYELMTNGSLQDQLQGPAQ---GAALTWHLRLKIALDAARGLEYLHDHCDPPVIHR
IRAKk_e-2_Smoe  QHLLCYELVPNGSLESWLHGRLG--ANNPLDWDTRMKIAIGAARGLAYLHEDCQPCVIHR
IRAKk_b-2_Smoe  YRLLVYSYMANGSLQEHLHSKGK----STLDWGTRILVAFDAAKGLEYLHEYVIPPIIHR
IRAKk_c-2_Smoe  HRLLVYEFMPNGSVQEHLHSDGTSGRPPMLDWDTRMRVALDAARGLEYLHEMVSPPIIHR
IRAKk_b-1_Smoe  YRLLVYSYMANGSLQEHLHSKGK----STLDWGTRILVAFDAAKGLEYLHEYVIPPIIHR
IRAKk_a-1_Smoe  HRLLVYEYMAKGNLQQHLYPDDDDHGFVPLDWTTRLKIALDAAKGLEFLHEFVTPPIIHR
IRAKk_a-2_Smoe  HRLLVYEYMAKGNLQQHLYPDEDDHGFVPLDWTTRLKIALDAAKGLEFLHEFVTPPIIHR
IRAKk_e-1_Smoe  QHLLCYELVPNGSLESWLHGRLG--ANNPLDWDTRMKIAIGAARGLAYLHEDCQPCVIHR
IRAKk_f_Smoe    DRLLIYELMTNGSLQDQLQGPAQ---GAALTWHLRLKIALDAARGLEYLHDHCDPPVIHR
IRAKk_d_Smoe    MRSLVYELIPNGSVDSHLHGDDK--KIAPLSWEARLKIALGAARGLAYLHEDSYPRVIHR
                 : * *. :.:*.::. *           * *  *: :*:.**:** :**:   * :***

IRAKk_c-1_Smoe  DFKSSNILLDDKFNAKVSDFGLAKLGSDKAGGHVSTRVLGTQGYVAPEYALTGHLTTKSD
IRAKk_g_Smoe    DFKSSNILLDEDFNAKLSDFGLALMVQEGA---GSLQLQGTFGYVAPEYILTGILTEKSD
IRAKk_e-2_Smoe  DFKASNILLEDNFQAKVADFGLAKQAPEGQTSYVSTRVMGTFGYVAPEYAMTGHLLVKSD
IRAKk_b-2_Smoe  DFKSSNILLDEHNDVVLADFGLAKTGADKIAGQPSTRVLGTQGYLAPEYAMTGHLTTKSD
IRAKk_c-2_Smoe  DFKSSNILLNDKYNAKVSDFGLAKLGSDKAGGHVSTRVLGTQGYVAPEYALTGHLTTKSD
IRAKk_b-1_Smoe  DFKSSNILLDEHNDVVLADFGLAKTGADKIAGQPSTRVLGTQGYLAPEYAMTGHLTTKSD
IRAKk_a-1_Smoe  DFKCSNILLDDKLNAKLSDFGLAKVGSNKVNGDVSTRVLGTHGYVAPEYVLTGHLTTKSD
IRAKk_a-2_Smoe  DFKCSNILLDDKLNAKLSDFGLAKVGSNKVNGDVSTRVLGTHGYVAPEYVLTGHLTTKSD
IRAKk_e-1_Smoe  DFKASNILLEDNFQAKVADFGLAKQAPEGQTSYVSTRVMGTFGYVAPEYAMTGHLLVKSD
IRAKk_f_Smoe    DFKSSNILLDEDFNAKLSDFGLALMVQEGA---GSLQLQGTFGYVAPEYILTGILTEKSD
IRAKk_d_Smoe    DFKSSNILLEDDFTPKVSDFGLAKAASEELTGHISTRVMGTFGYVAPEYAMTGHLLVKSD
                ***.*****::.    ::*****    :      * :: ** **:**** :** *  ***

IRAKk_c-1_Smoe  VYSFGVVLLELLTGRVPVDMKRPPGEGVLVSWALPRLTDRNKMVEIIDPRLNGQFAMKDL
IRAKk_g_Smoe    VYAFGVVLLELITGRKPIDVSMPTGCQSLVTWATPQLTDRTRLPLIVDAAIKDTVNLKQL
IRAKk_e-2_Smoe  VYSYGVVLLELLSGRKPVDMAQPTGQENLVTWARPVLKDVDRIYELADPRLNGQYPREDF
IRAKk_b-2_Smoe  VYSYGVVLLELITGRLPVDAKRPPGQNVLVNWALPRLTDREKLAQMVDPYLRSQYNMKEL
IRAKk_c-2_Smoe  VYSFGVVLLELLTGRVPVDMKRPPGEGVLVSWALPRLTDRNKMVEIIDPRLNGQFAMKDL
IRAKk_b-1_Smoe  VYSYGIVLLELITGRLPVDAKRPPGQNVLVNWALPRLTDREKLAQMVDPYLRSQYNMKEL
IRAKk_a-1_Smoe  VYSFGVVLLEILTGRVPVDMKRPAGEGVLVSWALPRLTDRDKLVGMVDQALAGQYSMKEL
IRAKk_a-2_Smoe  VYSFGVVLLEILTGRVPVDMKRPAGEGVLVSWALPRLTDRDKLVGMVDQALAGQYSMKEL
IRAKk_e-1_Smoe  VYSYGVVLLELLSGRKPVDMAQPTGQENLVTWARPVLKDVDHIYDLADPRLNGQYPREDF
IRAKk_f_Smoe    VYAFGVVLLELITGRKPIDVSMPTGCQSLVTWATPQLTDRTRLPLIVDAAIKDTVNLKQL
IRAKk_d_Smoe    VYSYGVVLLELLSGRKPVDMSRAQGQENLVTWARPLLTSLEGLDFLADPDLRSSVAPENL
                **::*:****:::** *:*   . *   **.** * *..   :  : *  : .    :::

IRAKk_c-1_Smoe  IQIAAIAAMCVQPEADYRPFITDVVQSLVPLVKHNRP----------MR-VSSSPSFLHA
IRAKk_g_Smoe    FQVAAVAVLCVQSEPSYRPLIGDVVNSLIPLVPCELGGA--------LR-AID-PA----
IRAKk_e-2_Smoe  AQVAAVAAACVAPEANQRPTMGEVVQSLKMVQHSNEYTHSGERENMTVETPVS-PSMSDG
IRAKk_b-2_Smoe  VQVAAIAAMCVQPEPDYRPLITDVVQSLIPLVRQRRMGT-------PKR-SVSSPRCVSS
IRAKk_c-2_Smoe  IQIAAIAAMCVQPEADYRPFITDVVQSLVPLIKHNRP----------MR-VLSSPSFLHA
IRAKk_b-1_Smoe  VQVAAIAAMCVQPEPDYRPLITDVVQSLIPLVRQRRMGT-------PKR-SVSSPRCVSS
IRAKk_a-1_Smoe  IQVAAIAAMCIQPEADYRPLMIDVVQSLAPLVKQRLQ-----------------------
IRAKk_a-2_Smoe  IQVAAIAAMCIQPEADYRPLMIDVVQSLAPLVKQRLQ-----------------------
IRAKk_e-1_Smoe  AQVAAVAAACVAPETNQRPTMGEVVQSLKMVQHSNEYTHSGERENMTVETPVS-PSMSDG
IRAKk_f_Smoe    FQVAAVAVLCVQSEPSYRPLIGDVVNSLIPLVPCELGGA--------LR-AID-PS----
IRAKk_d_Smoe    ARVAAIASMCVRPEVSQRPFMGEVVQALKLVCSDMDV-EEGET-SGASN-SVSSPEAKAK
                 ::**:*  *: .* . ** : :**::*  :

IRAKk_c-1_Smoe  -TVT--------------------------------------------------------
IRAKk_g_Smoe    --GAT-------------------------------------------------------
IRAKk_e-2_Smoe  -TFATSW--------------------------------------NNHNTRQTSATFESD
IRAKk_b-2_Smoe  -LL---------------------------------------------------------
IRAKk_c-2_Smoe  -IVT--------------------------------------------------------
IRAKk_b-1_Smoe  -LL---------------------------------------------------------
IRAKk_a-1_Smoe  ------------------------------------------------------------
IRAKk_a-2_Smoe  ------------------------------------------------------------
IRAKk_e-1_Smoe  -TFATSW--------------------------------------HNHNTRQTSATFESD
IRAKk_f_Smoe    --GAT-------------------------------------------------------
IRAKk_d_Smoe    VTAASTSRQREWDFLSYRSSSDFDDQQKSLRNHQRQQGQGGNFSASSALLRQVSASFGRH


IRAKk_c-1_Smoe  --------------------VKSSSAESGSSDCRSSHVSF
IRAKk_g_Smoe    ------------------------------AANSHSQHGV
IRAKk_e-2_Smoe  GTS---SFFSSGPFSGLAALDEGEDAQRGPTMSEDLLEGR
IRAKk_b-2_Smoe  ---------------------KSPTTQSPAL-KANIKTLQ
IRAKk_c-2_Smoe  --------------------VKSSSAESGSSDCRSSHVSF
IRAKk_b-1_Smoe  ---------------------KSPTTQSPAL-KANIKTLQ
IRAKk_a-1_Smoe  ------------------------------------NRTG
IRAKk_a-2_Smoe  ------------------------------------NRTG
IRAKk_e-1_Smoe  GTS---SFFSSGPFSGLAALDEGEDAQRGPTMSEDLLEGR
IRAKk_f_Smoe    ------------------------------AANSHSQHGV
IRAKk_d_Smoe    SAPEPLKFFNKS--ERFLTLPPGSASEHGVHHYRESTVWP