MAP3K1_Mmus MAAAAGDRASSSGFPGAAAASPEAGGGGGGGGALQGSGAPAAGAAGLLREPGSAGRERAD
MAP3K1_Hsap MAAAAGNRASSSGFPGARATSPEAGG---GGGALKASSAPAA-AAGLLREAGSGGRERAD
MEKK1_Spur MAIAHLKLE---------------------------------------------------
AqueK225_Aque MEGAKQQK----------------------------------------------------
* * .
MAP3K1_Mmus WRRRQLRKVRSVELDQLPEQPLFLAAASPPCPSTSPSPEPADAAAGASRFQPAAGPPPPG
MAP3K1_Hsap WRRRQLRKVRSVELDQLPEQPLFLAA-SPPASSTSPSPEPADAAGSGTGFQPVAVPPPHG
MEKK1_Spur ----------KA-----------------------------------HLLEPLVVPFASL
AqueK225_Aque ------------DVPQPPVQPISL------------------------------------
MAP3K1_Mmus AASRCGSHSAELAAARDSGARSPAGAEP----------PSAAAPSGREM----ENKETLK
MAP3K1_Hsap AASRGGAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREM----ENKETLK
MEKK1_Spur ADDRGSDHVLAIAGGVEARVLRNHLLMPMEARSLN---------LSRELLLQSSSDKEMK
AqueK225_Aque ------------------------------------------------------------
MAP3K1_Mmus GLHKMEDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPIKGDGSEMNNLAAE
MAP3K1_Hsap GLHKMDDRPEERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAE
MEKK1_Spur RMSKLDDPLEKNAIREKLRGK---------------------------------------
AqueK225_Aque --------------------RILFAEDHQWLKVDTH------------------------
MAP3K1_Mmus PQGEGQAGSAAPAPKGRRSPSPGSSPSGRSVKPESPGVRRKRVSPVPFQSGRITPPRRAP
MAP3K1_Hsap SPGEVQASAASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAP
MEKK1_Spur -PGVRREGGDAPRTKGPMGSRPGSPTGG---------------------------HRRVP
AqueK225_Aque -----------------LSVCPGNGCSV--------------------------------
. **. .
MAP3K1_Mmus SPDGFSPY--SPEETSRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSC
MAP3K1_Hsap SPDGFSPY--SPEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSC
MEKK1_Spur SPNNDCLFTLAVGVLKKRVERALHARLFLLTQSGPNSFLIGGDSPDHKYKVTIGSQNCNC
AqueK225_Aque ------------------------------------------------------------
MAP3K1_Mmus GRGAFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVES------------LFQKYHSRRS
MAP3K1_Hsap ARGTFCIHLLFVMLRVFQLEPSDPMLWRKTLKNFEVES------------LFQKYHSRRS
MEKK1_Spur GKGPFCVHLLFVMLRVFKLAEDDNLLWNRTLKNYEVEL------------LFSKYEAMKK
AqueK225_Aque ----------------------DVCLYIRALCAHEIDQCPEYCSWCSKVRRWLRYHARSC
* *: ::* .*:: : :*.:
MAP3K1_Mmus SRIK-APSR----NTIQKFVS-RMSN-CHTLSSSSTSTSSSENSIKDEEEQMCPICLLGM
MAP3K1_Hsap SRIK-APSR----NTIQKFVS-RMSN-SHTLSSSSTSTSSSENSIKDEEEQMCPICLLGM
MEKK1_Spur KKLKHSPSQ----SSQRSRRS-SQSPSTSHLPRPSSPCPSTGSSDQREDEDLCPICLLEM
AqueK225_Aque KPKK-CPYNHFCNETQKKFFRRRMT-IPYSEQWSKGPTSSLH------------------
. * .* . .: :. : .. . .*
MAP3K1_Mmus LDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVE
MAP3K1_Hsap LDEESLTVCEDGCRNKLHHHCMSIWAEECRRNREPLICPLCRSKWRSHDFYSHELSSPVD
MEKK1_Spur VEGESLVECKNGCHNKLHHHCVAIWEGECKRQQEPMVCPLCRAIWADCAHENQEAGAASS
AqueK225_Aque ------------------------------------------------------------
MAP3K1_Mmus SPTSLRAVQQPSSPQQPVAGSQRRNQESSFNLTHFGTQQIPSAYKDLAEPWIQVFGMELV
MAP3K1_Hsap SPSSLRAAQQQTVQQQPLAGS-RRNQESNFNLTHYGTQQIPPAYKDLAEPWIQVFGMELV
MEKK1_Spur TP-------HPSTEQGPVEEEAGITESSRL-----------QTFQQKKEGWKEAFDNSLV
AqueK225_Aque ------------------------------------------------------------
MAP3K1_Mmus GCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGGSGGSLSAGAASGSSQPSISG
MAP3K1_Hsap GCLFSRNWNVREMALRRLSHDVSGALLLANGESTGNSGGSSGSSPSGGATSGSSQTSISG
MEKK1_Spur EAMFSRDWGIRENTLHSLSQQLASKLKHSR-E----------GLLNEPHDVETCEQCFQA
AqueK225_Aque -------------------------------SSASESSVSS-GSIPVGGAMGTTRHSITA
. . : . .: .
MAP3K1_Mmus DVV--EACCSVLSIVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLRPVVDTI
MAP3K1_Hsap DVV--EACCSVLSMVCADPVYKVYVAALKTLRAMLVYTPCHSLAERIKLQRLLQPVVDTI
MEKK1_Spur DMITMESGFMMVAMACSDPVYKVYVAALRVLRTLLMCSHCSTEDQQAQLRKWLQPVMSAI
AqueK225_Aque ------------------------------------------------------------
MAP3K1_Mmus LVKCADANSRTSQLSISTVLELCKGQAGELAVGREILKAGSIGVGGVDYVLSCILGNQ--
MAP3K1_Hsap LVKCADANSRTSQLSISTLLELCKGQAGELAVGREILKAGSIGIGGVDYVLNCILGNQ--
MEKK1_Spur LVKSADGNRRTAQLSVSAMFELARGDSGELAVSKELSCSSCIGLGSLDYILSCLISDIQI
AqueK225_Aque ------------------------------------------------------------
MAP3K1_Mmus -AESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQS
MAP3K1_Hsap -TESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTDVSQAEPVEIRYKKLLSLLTFALQS
MEKK1_Spur NVGETSWQHILGCLCVLERVFSDFPERFV---ITEDHSSEVEKASKIECLVSIATCVSSY
AqueK225_Aque ------------------------------------------------------------
MAP3K1_Mmus IDNSHSMVGKLSRRIYLSSARMVTAVPAVFSKLVTMLNASGSTH-FTRMRRRLMAIADEV
MAP3K1_Hsap IDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEMLSVSSSTH-FTRMRRRLMAIADEV
MEKK1_Spur LNSSHTRMCKIAKKISVTVAKILVADASGFARICDMMRTLESREVGSRMLRRLQKILDEY
AqueK225_Aque ------------------------------------------------------------
MAP3K1_Mmus EIAEVIQLGVEDTVDGHQDS-LQVLAPASCL---ENSSLEHTVHREKTGKGLSATRLSAS
MAP3K1_Hsap EIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENSSPECTVHLEKTGKGLCATKLSAS
MEKK1_Spur EGAQDE---------------------------AAREREDAAVHGHDEGGGVCDDERDGR
AqueK225_Aque ------------------------------------------------------------
MAP3K1_Mmus SEDISDRLAGVSVGLPSST-----TTEQPKPAVQTK--GRPHSQCLNSSPLSH-AQLMFP
MAP3K1_Hsap SEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTK--GRPHSQCLNSSPLSHHSQLMFP
MEKK1_Spur RNGM---LSNI-------------------------------------------------
AqueK225_Aque --------------------------AGPGPSSTCRWGCSEEAKCCESGNC---------
MAP3K1_Mmus APSAPCSSAPSVP-----DISKHRPQAFVPCKIPSASPQTQRKFSLQFQRNCSEHRDSDQ
MAP3K1_Hsap ALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQTQRKFSLQFHRNCPENKDSDK
MEKK1_Spur -QDSPCAAE-------NTNVSSRRY-----------------------------------
AqueK225_Aque ------------------------------------------------------------
MAP3K1_Mmus LSPVFTQSRPPPSSNIHRPKPSRPVPGSTSKLGDATKSSMTLDLGSASRCDDSFGGGGNS
MAP3K1_Hsap LSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNSMTLDLNSSSKCDDSFGCSSNS
MEKK1_Spur ---------------DHAITPSRPSLRDNADGCFP-------------------------
AqueK225_Aque ---------------CHEPHPHDM--------ASPSSSSSSLVLSSSY-ITS--------
* * .
MAP3K1_Mmus GNAVIPSEETVFTPVEDKCRLDVNTELN-SSIEDLLEASMP-SSDTTVTFKSEVAVLSPE
MAP3K1_Hsap SNAVIPSDETVFTPVEEKCRLDVNTELN-SSIEDLLEASMP-SSDTTVTFKSEVAVLSPE
MEKK1_Spur ------------------TRTDSNEQTNVSDLSDLSSASPTTPCDNPICFKSEVAS-SPK
AqueK225_Aque ------------------------SYSQ-DIIQRALDERLP-ETETEV------------
: . :. . . :. :
MAP3K1_Mmus KAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSA-SQDALPIVPQLQVENGEDIII
MAP3K1_Hsap KAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSA-SQDALPIVPQLQVENGEDIII
MEKK1_Spur KRMAAFDFTLPGVGSKNCKDEVEAEEAEALAIAMEASMHTQCVLPCVPGLRTERDGDVII
AqueK225_Aque ------------------KAYIETKKQIRLAL----------------------------
* :*::: **:
MAP3K1_Mmus I--QQDTPETLPGHTK-AKQPYREDAEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVT
MAP3K1_Hsap I--QQDTPETLPGHTK-AKQPYREDTEWLKGQQIGLGAFSSCYQAQDVGTGTLMAVKQVT
MEKK1_Spur KIDHKNSTEEVDGVVSPRSKQYTESQNWTKGAILGTGAFSSCYMARDVKTGTLMAVKQIS
AqueK225_Aque ---------------LERHKFYQEGVHWERIKQLGCGSSGTTYCIRDRETSFWLALKE--
: * *. .* : :* *: .: * :* *. :*:*:
MAP3K1_Mmus YVRNTSSEQEEVVEALREE---IRMM-GHLNH-PNIIRMLGATC----EKSNYNLFIEWM
MAP3K1_Hsap YVRNTSSEQEEVVEALREE---IRMM-SHLNH-PNIIRMLGATC----EKSNYNLFIEWM
MEKK1_Spur FCRNNAGDQEDTMEEIKKE---IKLM-ATFDH-PHIVRLMGATQ----HDAHFNVFVEWM
AqueK225_Aque --------EQESLTAVNETLISLRLSSSSKDHPPNIVEFYGASLLPLQVETKLQLFLELM
::: : :.: ::: . :* *:*:.: **: .:: ::*:* *
MAP3K1_Mmus AGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRI
MAP3K1_Hsap AGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDSTGQRLRI
MEKK1_Spur PGGAVSTLLKDFGAFSNAVTVKYIHQVCLGLAYLHDNRVIHRDLKGANLLMDSTGHHLRI
AqueK225_Aque PCCLQ-SYLYNGGPLSVEDAHNYACQLFDALDYLHA----------GNLLIDENVQRLKV
. * . *.:. . :* *: .* *** .***:*.. ::*::
MAP3K1_Mmus ADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAK
MAP3K1_Hsap ADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAK
MEKK1_Spur ADLGTAGKMNADITRTDEFKGQFLGTISFMAPEVLRGEPYGRSCDIWSVGCCIIEMCTTK
AqueK225_Aque TDFGCSQVLEDSHQGYCMRGDANAGTVHYNPPEHYSEFRCSYALDIWQAGCCIIAMVTGR
:*:* : : . . **: : .** . : *:*..**.** * :
MAP3K1_Mmus PPWNAE------------KHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQ
MAP3K1_Hsap PPWNAE------------KHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQ
MEKK1_Spur PPWNNT------------AISNHYQLLFKIASANGPPPIPESLSPALRDITLRCLEAEPS
AqueK225_Aque RPWRSMYLDCRERRYRAEVQQSQIQQ---ICKVPYSHHVPGFLDPALQQLVQQCLSIDYR
**. ..: *... . :* *.*.*:::. :**. :
MAP3K1_Mmus DRPPSRELLKHPV-----------------------------------------------
MAP3K1_Hsap DRPPSRELLKHPV-----------------------------------------------
MEKK1_Spur ARPGVMELLKHPA-----------------------------------------------
AqueK225_Aque RRPSLKDCLGLLAQSDVVSDSCKGQWLSHLGLQPTCFSSSSSPAPKSFLVDIYLGSYVHY
** : * .
MAP3K1_Mmus -------------------------------------FR---------------------
MAP3K1_Hsap -------------------------------------FR---------------------
MEKK1_Spur -------------------------------------FT---------------------
AqueK225_Aque SHYSLLPGWLGSVSCDSHVTYSQLHELIRNSIPVTQLFRSMEFGLCDNLPNLIWQKSSIN
*
MAP3K1_Mmus -------------------------------TTW
MAP3K1_Hsap -------------------------------TTW
MEKK1_Spur ------------------------------QMKR
AqueK225_Aque HGTSDTTSEDIIQLSRPKGTDAIDSSKGVVVIVE