MEKK15_Mmus MNKNR---------------------LIHDFLGVVSRGDVECICGLIPEVHSVLGNLDFQ
MEKK15_Hsap ------------------------------------------------------------
MEKK15_Spur MISST-------------------------------------------------------
AqueK226_Aque MNGGTGKRTTYHKIAYDVLQSRRPQSAVDSLLEAAEIGDDRKLMELVSKYRTII---NLK
MEKK15_Mmus HPQTGNTPLITAAEENLAEVVEILLEGGADITLCNYSNQTALHVANGDIQRQLLAGKGIQ
MEKK15_Hsap ------------------------------------------------------------
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque CVSSGDTALITAARNGHSNIVEYLMKSGADPTLQNDIGENALDVAPPHIRDILLSQLSKE
MEKK15_Mmus APQ--MQLLRSSWLGDLKQLRHLLACEEFLDINFPNSHGLTPLMLAVRDVDLFESLD--L
MEKK15_Hsap -----MQLLQSSWQGDLEQVQHLLASEEFLDINFPNQHGLTPLMLAVRDVDLFESLD--M
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque RPSTANRLLQAAWLGDSVTVKKNLS-GGIINVNCKNSEGLTPLLLVTRDIKTFDKVHRVM
MEKK15_Mmus LTAYRPDEVLAELLRHHADPKLCDFSGKSAIHYVSQIESWRKQQLLDILMDSMPRPERHA
MEKK15_Hsap LTVYKPVEVLSQLLRHHADPKLCDFSGKSAIHYVSQIESSKKQQLLDILMSSMPKPERHA
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque KTDYDPLGVMQELLKHKADLRACDSNGRTALHLISNEGS---------------------
MEKK15_Mmus ESLLDICHEAGSTPME-MTVSQTENLTLQSISSSEDFDLEDDFSPFILAREGAAPRG--E
MEKK15_Hsap ESLLDICHDTNSSPTDLMTVTKNQNIILQSISRSEEFDQDGDCSHSTLVNEEEDPSGGRQ
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque -----------SSVG-AVQAKKVVSLLLQNGSSTNITDKNGY-TPLHIAA----------
MEKK15_Mmus NWPRRTEGVEIIVTFPPD--PLQEASQEDLKESNQVTSEHQEREQVHPVSPPDDAEMVGL
MEKK15_Hsap DWQPRTEGVEITVTFPRDVSPPQEMSQEDLKEKNLINSSLQEWAQAHAVSHPNEIETVEL
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque ------------------------------------------------------------
MEKK15_Mmus TGRMLTTQPSLLKTDGSSEELCGVDVALSPPRPCLDSSLAASAAGEVAPCVLKEQQRQSD
MEKK15_Hsap RKKKLTMRPLVLQKEESSRELCNVNLGFLLPRSCLELNISKSVTREDAPHFLKEQQRKSE
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque ------------------------------------------------------------
MEKK15_Mmus EFPTSDISYSSRRTGLPLPPLSCLPMRSCIFNMEKSPKSPRHRERKVPSLSLSVPKLLEP
MEKK15_Hsap EFSTSHMKYSGRSIKFLLPPLSLLPTRSGVLTIPQNHKFPKEKERNIPSLTSFVPKL---
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque ------------------------------------------------------------
MEKK15_Mmus LSRPLSQSAEFSSSKNHQEVTQEGPVEHTLRGSNCTLWSRNMCSFRKSGKQG----VAES
MEKK15_Hsap -SVSVRQSDELSPSNEPPGALVKSLMDPTLRSSDGFIWSRNMCSFPKTNHHRQCLEKEEN
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque ------------------------------------------------------------
MEKK15_Mmus WPSQEMEGWDKTKTSGFKEGPSLFSCESVKEDTTPTERERDSGYHVSEM---------QR
MEKK15_Hsap WKSKEIEECNKIEITHFEKGQSLVSFENLKEGNIPAVREEDIDCHGSKT---------RK
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque -----------------KNGHTAIIVALLEEG------ETDIDCRGGENRDTPLIISVRE
MEKK15_Mmus -GGEDSQYLSSRKKESWTARVVERDSGVEHPILCKLLEVSNSEMTPAEEKEIGNENVPDA
MEKK15_Hsap PEEENSQYLSSRKNESSVAKNYEQDPEIVCTIPSKFQETQHSEITPSQDEEMRNNK-AAS
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque GHKETAEYLLSKGADVTLT----------------------------ADS--GDT-----
MEKK15_Mmus KSNSVHKSG--------AMEPHAASEEVSVPKNGPSVNSDGPAEEL-EGHRDIEQNRKIP
MEKK15_Hsap KRVSLHKNE--------AMEPNNILEECTVLKSLSSVVFDDPIDKLPEGCSSMETNIKIS
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque -ALSVAKTSSMTALIKDAWDKSIASEPIGAPCEGSGTESDSN----------TDINTDLN
MEKK15_Mmus MEEETNPEMNGVVPLTHIAFPGEGTSKGPARAEPHLQRRKRPAQNSNSFNLLAHREHDKL
MEKK15_Hsap IAERAKPEMSRMVPLIHITFPVDGSPKEPVIAKPSLQTRKGTIHNNHSVNIPVHQENDKH
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque ADTDTDTDLAGTVTA---------------------------------------------
MEKK15_Mmus QTNTHRTKLDSRTKARNRAPPNLMVSIQASIKPNMHKNSIKTQVFPALELIDHRPHPSSK
MEKK15_Hsap KMNSHRSKLDSKTKTSKKTPQNFVISTEGPIKPTMHKTSIKTQIFPALGLVDPRPWQLPR
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque --------------------PFFITQNNGQLRSSRSLSEIATRSIERVG-----------
MEKK15_Mmus FQRRAPL-TEKKSTHQTQKPKKQAFPRIGKHAGIKKPGIPLSAETTDPRLHFLDLKYSDM
MEKK15_Hsap FQKKMPQIAKKQSTHRTQKPKKQSFPCICKNPGTQKSCVPLSVQPTEPRLNYLDLKYSDM
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque -------------------------------------------QETMTRLESVDNNDKYM
MEKK15_Mmus FKEINSASNGPGIYEMFGTPVYCHIREAERHDHRCYREIRTAPSGRCVVNKCQSSESDRC
MEKK15_Hsap FKEINSTANGPGIYEMFGTPVYCHVRETERDENTYYREICSAPSGRRITNKCRSSHSERK
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque -------------TRQSSTPDHSQYSEVEADDEQEYNKISKRH-----------TPARRR
MEKK15_Mmus SNSRARLLQKRQHIKPPKPLHGLRQKHRGFISKDKGCKDMGGH-----TEDSVSEPDGQM
MEKK15_Hsap SNIRTRLSQKKTHMKCPKTSFGIKQEHKVLISKEKSSKAVHSNLHDIENGDGISEPDWQI
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque SLLRQSLITSKRNTTNAES--ALRRSQLAL------------------------------
MEKK15_Mmus KSPGNDFLSSKDDAQLMHLIPIPELSPEQKAPAPVSDLSIVEEIFTE---ECADEEGILN
MEKK15_Hsap KSSGNEFLSSKDEIHPMNLAQTPEQSMKQNEFPPVSDLSIVEEVSME---ESTGDRDISN
MEKK15_Spur ------------------------------------------------------DRSLST
AqueK226_Aque -----------------------------SGGGSSSTLSVVKEEYSSSDKTLTPTDGRPD
.
MEKK15_Mmus DDSLTQSLGDLKEPEGLHPQ------APLVPSENS-WAVLSEKRSGKRVSPEKHNVEPLD
MEKK15_Hsap NQILTTSLRDLQELEELHHQ------IPFIPSEDS-WAVPSEKNSNKYVQQEKQNTASLS
MEKK15_Spur NTT---------------------------------------------------------
AqueK226_Aque NDDTIKSRRDLKSRDNLIKSRCDSRHDTMIPSYYDELAT--ASNNDEYIT---------S
:
MEKK15_Mmus KINAEQMFPGYLEFDSLSEKSKTLVSFSSCSFQENLERAPSPTEQHWARSLEQDSLENNS
MEKK15_Hsap KVNASRILTNDLEFDSVSDHSKTLTNF---SFQAKQESASSQTYQYWVHYLDHDSLANKS
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque NIGSRTPFPYHLLADTSGSG----------------------------------------
MEKK15_Mmus TTYQTFGK-------ISQEILDPGKNEELTDELLGCLVEELLALDEKDNNSCQIMTNEAD
MEKK15_Hsap ITYQMFGKTLSGTNSISQEIMDSVNNEELTDELLGCLAAELLALDEKDNNSCQKMANETD
MEKK15_Spur ------------------------------------------------------------
AqueK226_Aque --------------PRKTSGIDSGH-----------------------------------
MEKK15_Mmus AKNLNLVFSRRGNTIEELGRETTDVKLQRCINGFRIYD-EENFLTSNEKKTLSDKSLNHE
MEKK15_Hsap PENLNLVLRWRGSTPKEMGRETTKVKIQRHSSGLRIYDREEKFLISNEKKIFSENSLKSE
MEKK15_Spur ---------------------------------------------------VSE--SEGT
AqueK226_Aque ----------------------------------EG-ESEESE-SSSEEEEEREE-QEET
: :
MEKK15_Mmus EAIFWTKGEILGRGAYGTVYCGLTSLGQLIAVKQVALDTSDKLATEKEYRKLQEEVDLLK
MEKK15_Hsap EPILWTKGEILGKGAYGTVYCGLTSQGQLIAVKQVALDTSNKLAAEKEYRKLQEEVDLLK
MEKK15_Spur ELLHWKKGNLLGKGAFGTVYCGLTNTGQLLAVKQVELSEIDKEKAKQQYLKLQEEVQLLK
AqueK226_Aque EELRWKKGKLLGRGAYGKVYEGLLDTARLIAVKEVELEVEDNEKALVQFKKIQLEVDILR
* : *.**::**:**:*.** ** . .:*:***:* *. :: : :: *:* **::*:
MEKK15_Mmus ALKHVNIVAYLGTCLEENTLSIFMEFVPGGSISSIINRFGPLPEMVFCKYTRQILQGVAY
MEKK15_Hsap ALKHVNIVAYLGTCLQENTVSIFMEFVPGGSISSIINRFGPLPEMVFCKYTKQILQGVAY
MEKK15_Spur TLRHKNIVGFLGVSLEDNVVNIFMQFIPGGSIASLLARFGSLDETVFCRYTKQILEGTQY
AqueK226_Aque SLSHKNIVQYLGTSINETIVYIFMEYITGGSLQSILKRFGSLNEKTIVRYVRQMGRGLNY
:* * *** :**..:::. : ***:::.***: *:: ***.* * .: :*.:*: .* *
MEKK15_Mmus LHDNCVVHRDIKGNNVMLMPTGIIKLIDFGCAKRLAWAGLNGTHSDMLKSMRGTPYWMAP
MEKK15_Hsap LHENCVVHRDIKGNNVMLMPTGIIKLIDFGCARRLAWAGLNGTHSDMLKSMHGTPYWMAP
MEKK15_Spur LHENNVIHRDIKGANIMLMSTGVIKLIDFGCAKRLCIQISRS--QNVLKSMRGTPYWMAP
AqueK226_Aque LHNNGVIHRDIKGANVMVSAHGTVKLIDFGCAKRHCLDQSLG-----FHSVRGTPYWMAP
**:* *:****** *:*: . * :********:* . . ::*::********
MEKK15_Mmus EVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPARFSEP
MEKK15_Hsap EVINESGYGRKSDIWSIGCTVFEMATGKPPLASMDRMAAMFYIGAHRGLMPPLPDHFSEN
MEKK15_Spur EVIMETGHGKKSDIWSIGCTVFEMATRKPPWADMPPMAAIFAIGSGDP-VPQLPVKFSED
AqueK226_Aque EVICGRGYGRKSDIWSLGCTMYEMIFTRPPWGDLPPEAAMFKIGLGQS-LPPLPKNSSME
*** *:*:******:***::** :** ..: **:* ** :* ** . *
MEKK15_Mmus AADFVRLCLTRDQHERPSALQLLKHSFLKR------------------------------
MEKK15_Hsap AADFVRMCLTRDQHERPSALQLLKHSFLERS-----------------------------
MEKK15_Spur ARMFVNACLTRDQDERATASELLKHPFIKRRKERGREHYHQTRISSTSLEDGPIVFREQP
AqueK226_Aque LISLYTACLKSDPGQRPTAQEVLDHAFLQK------------------------------
: **. * :*.:* ::*.*.*:::
MEKK15_Mmus -------------------S
MEKK15_Hsap -------------------H
MEKK15_Spur ISRDSAESKGRKNYAPHEFR
AqueK226_Aque -------------------K