MAPKAPK5_Hsap MSEE--------------------------------------------------------
MAPKAPK5_Mmus MSED--------------------------------------------------------
MAPKAPK5b_Spur MSLFTPITNLRLGGSTPIAPDNQAVYITEVDAQKRFARCGEPLIAMVCSDHTIKLVGKET
AqueK074_Aque MRRVSGA-----------------------------------------------------
*
MAPKAPK5_Hsap ------------------------------------------------------------
MAPKAPK5_Mmus ------------------------------------------------------------
MAPKAPK5b_Spur MSSAGQLKGHGGPVSGVKFAHRNPFTVFSSSRDGTVRCWDTRMKRNKAPQVFTGYEGNSF
AqueK074_Aque ----------------IDFVYKLPFWSYSRLQ----RREEALLTLPVASLLFGSITGNLI
MAPKAPK5_Hsap ---------------SDMDKAIKETSILEEYSINWTQ-----------------------
MAPKAPK5_Mmus ---------------SDMEKAIKETSILEEYSINWTQ-----------------------
MAPKAPK5b_Spur TSFD-------INSTDDILSAGTEAVDNDAYLMFWDRRSTNLLGTYKESHSDDITQVKFH
AqueK074_Aque NRKRSKPQNLSLMSKYERDPEFKKTSILDDYEIKWNR-----------------------
: .:: : * : * :
MAPKAPK5_Hsap -----KLGAGI-SGPVRVCVKKSTQERFALKILLDRP---KARNEV------RLHMMCAT
MAPKAPK5_Mmus -----KLGAGI-SGPVRVCVKKSTQERFALKILLDRP---KARNEV------RLHMMCAT
MAPKAPK5b_Spur PTKSSSLATGSTDGLVCVFDTSQTNEEDALVTTLNSE---SSVSHIDWCGTNSEYLYCLT
AqueK074_Aque -----SLGTGV-SGPVRLCIHRATGKEYALKLLLDRSDRKKAEIEA------TLHWRCSG
.*.:* .* * : * :. ** *: .: . : *
MAPKAPK5_Hsap HPNIVQIIEVFANSVQFPHESSPRA---------------------RLLIVMEMMEGGEL
MAPKAPK5_Mmus HPNIVQIIEVFANSVQFPHESSPRA---------------------RLLIVMEMMEGGEL
MAPKAPK5b_Spur HTETIRIFDAVESSEITK-FDSVRESLKEDRCKVDYLVDCFYHSGLKSLVVLGGTVGGDL
AqueK074_Aque GDHIVRIVDIYRNEIQQPGELSPKK---------------------RILLVMELMEGKEL
. ::*.: .. * : : *:*: * :*
MAPKAPK5_Hsap FH-RI-SQHRHFTEKQASQVTKQATLALRHCHLLNIAHRDLKPENLLFK-----------
MAPKAPK5_Mmus FH-RI-SQHRHFTEKQASQVTKQIALALQHCHLLNIAHRDLKPENLLFK-----------
MAPKAPK5b_Spur HLLTVGKDRLHFVHS----------LKGTHKGVVRCLHWDNQTETLVTGGEDSIVSAWQP
AqueK074_Aque FD-YI-SKRHHFTEHEASKYILQIVRGVQFCHRLNIAHRDIKPENLLLLKPA--------
. : ..: **.. . :. * * :.*.*:
MAPKAPK5_Hsap -DNS-LDAPVKLCDFGFAKIDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTP
MAPKAPK5_Mmus -DNS-LDAPVKLCDFGFAKVDQGDLMTPQFTPYYVAPQVLEAQRRHQKEKSGIIPTSPTP
MAPKAPK5b_Spur DRNANQSSSKKGSPAQTSRIRQGRRAEKRGSPV----KVLEAQKRQRREQKNLIQTSPRP
AqueK074_Aque -SNP-EDVVIKLSDFGFAKVDNGDLKTPQFTPYYVAPQVLEAQKRQKESLSGYK--HRTP
*. . * . ::: :* : :* :*****:*::.. .. *
MAPKAPK5_Hsap YTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRRKIMTGSFEFPEEEWSQISE
MAPKAPK5_Mmus YTYNKSCDLWSLGVIIYVMLCGYPPFYSKHHSRTIPKDMRKKIMTGSFEFPEEEWSQISE
MAPKAPK5b_Spur YTYDKGCDMWSLGVIIYIMLCGYPPFYPDTPSRQLSKDMRHKIMAGQYEFPTEEWSLISD
AqueK074_Aque YYYDKSCDIWSIGVIMYIMLCGYPPFYSEVPHQALSNRMKQKIMSADFDFPENDWKAVTD
* *:*.**:**:***:*:*********.. : :.: *::***:..::** ::*. :::
MAPKAPK5_Hsap MAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAE
MAPKAPK5_Mmus MAKDVVRKLLKVKPEERLTIEGVLDHPWLNSTEALDNVLPSAQLMMDKAVVAGIQQAHAE
MAPKAPK5b_Spur EAKDVVKRLLRVDPTERLTIEELCSHPWLRENSAPNTELHSPAIMLDKNMLDDAKQIHSE
AqueK074_Aque EAKDLIRKMLCVEPSERLSIEEVLHHPWLAQNASPNRDLNSPYLISDKDALVEVQGAHAK
***:::::* *.* ***:** : **** .. : : * *. :: ** : : *::
MAPKAPK5_Hsap QLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDS-VYIHDHENG--AEDSNVALEK
MAPKAPK5_Mmus QLANMRIQDLKVSLKPLHSVNNPILRKRKLLGTKPKDG-IYIHDHENG--TEDSNVALEK
MAPKAPK5b_Spur QLTAMRIPDKKVMLKPVAKANNPIVRKRILTRGQSIDN-KIGEEQPPKKQNRENSEGVTC
AqueK074_Aque LLQNFRRDDTGFYLKPLGQAKNPVLASRMKKQEEKKESGGAGNESEP-----SSSKAVQS
* :* * . ***: ..:**:: .* : :. .: ... .:
MAPKAPK5_Hsap LRDVIAQCILPQAGKGENE-----DEKLNEVMQEAWKYNRECKLLRDTLQSFSWNGRGFT
MAPKAPK5_Mmus LRDVIAQCILPQAGKGENE-----DEKLNEVMQEAWKYNRECKLLRDALQSFSWNGRGFT
MAPKAPK5b_Spur LRNIIAHCIVPP--KDANG-----EDALCELMKRACQYNRDCPSLDKALNNLSWNGEQFC
AqueK074_Aque LKSLMDVCNMPPPPPSLSSESSLSSSFLSESVKNALVLNEHNASLLKALEQESWNGNEFI
*:.:: * :* . . .. * * ::.* *.. * .:*:. ****. *
MAPKAPK5_Hsap DKVDRLKLAEIVKQVIEEQTTSHESQ
MAPKAPK5_Mmus DKVDRLKLAEVVKQVIEEQTLPHEPQ
MAPKAPK5b_Spur DKVDRSELALLLKDIVDQK-ERHEKC
AqueK074_Aque HQVNCKRLASSLQELIEQL-E----P
.:*: .** :::::::