p70S6Kb_Hsap -----------------------MAAVFDLDLETEEG--SEG----------------E-
p70S6K_Hsap MRRRRRRDGFYPAPDFRDREAEDMAGVFDIDLDQPEDAGSED----------------E-
p70S6Kb_Mmus -----------------------MAAVFDLDLETEEG--SEG----------------E-
p70S6K_Mmus MRRRRRRDGFYLAPDFRHREAEDMAGVFDIDLDQPEDAGSED----------------E-
R04A9.5_Cele MKQ---------------------------------------------------------
S6kII_Dmel MADV-----------------SDPSELFDLELHDLE--LQDDKARDSDD-----------
YBR028C_Scer MI-------------------------FSLDEELHRVSLDDKKNDIKVDYSSAIYNDIN-
p70RSK_Spur MAG--------------------HAGVFDLELCEHDEKANEC------------------
Y47D3A.16_Cele MA-----------------------DVFEFELEGHESQASPQRHAYHYD---------NC
AqueK024_Aque MSDPD------------------LA--DGLELDQEE-IGSDD----------------E-
p70S6Kb_Hsap --GEPELSP--ADAC-P--L--AELR-AAGLE--P-------------------------
p70S6K_Hsap --LEEGGQL--NES-----M--DHGG-VGPYE-LG-------------------------
p70S6Kb_Mmus --GEPEFSP--ADVC-P--L--GELR-AAGLE--T-------------------------
p70S6K_Mmus --LEEGGQL--NES-----M--DHGG-VGPYE-LG-------------------------
R04A9.5_Cele ------------------------------------------------------------
S6kII_Dmel ----DRIEL--DD----VDL--EPE-LCINLH-QD-------------------------
YBR028C_Scer --HEQGSSITYEESINHLSVHSNAI-PLNGMSPAHRMRRRSSAYSKFPILTPPNTRRFSI
p70RSK_Spur --LSDSDDM--QDEGAEG----DSY-LADGA--YE-------------------------
Y47D3A.16_Cele TEIMEDDHM--YSNVADGQI--SAPPPSSSY--ME-------------------------
AqueK024_Aque --VEEMMDG--TLIEDNSGL--VSGG-V-NID-ST-------------------------
p70S6Kb_Hsap -----V-GHYEEVE-----LTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQ-G
p70S6K_Hsap -----M-EHCEKFE-----ISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-G
p70S6Kb_Mmus -----V-GHYEEVE-----LTESSVNLGPERIGPHCFELLSVLGKGGYGKVFQVRKVQ-G
p70S6K_Mmus -----M-EHCEKFE-----ISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVT-G
R04A9.5_Cele ------------VS-----MQKFEKLFYPDDVAPKDFERLKLVGEGGYGKVFQVRKQT-G
S6kII_Dmel -----T-EGQETIQ-----LCEENVNPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTA-G
YBR028C_Scer TGSDAMRTNTNRLSITPQDIISSNIGENELSRNLHDFKPVRVLGQGAYGKVLLVKDV---
p70RSK_Spur -----S-IEVEEVS-----LSEETVNPGTEKVGPTDFQLLKVLGKGGYGKVFQVRKTT-G
Y47D3A.16_Cele -----D-PMMESIQ-----LCASAINPPNVRVGPEDFQLLKVLGKGGYGKVFQVRKTT-G
AqueK024_Aque -----A-GCLETLD-----ITPESINNTPEKIGPDCFELLKVLGKGGYGKVFQVRKRTGG
.. : *: ::*:*.****: *:.
p70S6Kb_Hsap TNLGKIYAMKVLRKAKIVRNAKDT-------------------------AHTRAERNILE
p70S6K_Hsap ANTGKIFAMKVLKKAMIVRNAKDT-------------------------AHTKAERNILE
p70S6Kb_Mmus TNLGKIYAMKVLRKAKIVCSAKDT-------------------------AHTRAERNILE
p70S6K_Mmus ANTGKIFAMKVLKKAMIVRNAKDT-------------------------AHTKAERNILE
R04A9.5_Cele EDKGTIYAMKVITKRKVTGTEKDL-------------------------RHARDERKILE
S6kII_Dmel RDANKYFAMKVLKKASIVTNQKDT-------------------------AHTRAERNILE
YBR028C_Scer -NTSKLYAMKQLRKAEILISQTATDSKREDEDKNDGNNNDNDDGLSKRLERTFAERSILS
p70RSK_Spur KDSGKIFAMKVLKKAKIVRNQKDT-------------------------AHTKAERNILE
Y47D3A.16_Cele SDNGQIFAMKVLQKATIVRNQKDT-------------------------AHTKAERNILE
AqueK024_Aque KDKGRIFAMKVLKKASIVRSKKDT-------------------------MHTRSERNILE
: . :*** : * : . . :: **.**.
p70S6Kb_Hsap SVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGH
p70S6K_Hsap EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH
p70S6Kb_Mmus SVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGH
p70S6K_Mmus EVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGH
R04A9.5_Cele TINSPFLCDLHYAFQTNEKLYLVLEFLHGGELYTLLERKSDWPEEYARFYLSEIILAIEH
S6kII_Dmel AVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGH
YBR028C_Scer EIEHPNIVKLFYSFHDNSKLYLLLQYIPGGELFYHLKEHGTLDETTVSFYAAEISCALRF
p70RSK_Spur AVQHPFIVDLHYAFQTGGKLYLILAYLGGGELFMHLEREGIFMEDTACFYLSEIVLALEH
Y47D3A.16_Cele AVKSPFICDLLYAFQTGGKLYLILEYLSGGELFMHLEREGMFMENVAKFYLSEIVVSLEH
AqueK024_Aque AIQHPFIVSLLYAFQTNGKLYLILDYLSGGELFALLEREGVFLEDTASFYLAEITLAIGH
:: * : .* *:*: . ****:* : ****: *:... * . ** :** :: .
p70S6Kb_Hsap LHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAV----------THTFCGTIE
p70S6K_Hsap LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTV----------THTFCGTIE
p70S6Kb_Mmus LHSHGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAI----------THTFCGTIE
p70S6K_Mmus LHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTV----------THTFCGTIE
R04A9.5_Cele LHGHDIVYRDLKPDNVMLNLAGHVVLTDFGLCKYKLKKGEK----------TLTFCGTHE
S6kII_Dmel LHKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIV----------THTFCGTIE
YBR028C_Scer LHTKGVVYRDLKPENCLLNQRGHLVLTDFGLSKKSANDSAVDEEDPENVNALYSIIGTPE
p70RSK_Spur LHKLGIIYRDLKPENIMLNKQGHVVLTDFGLCKESLEEGSM----------THTFCGTIE
Y47D3A.16_Cele LHQQGIIYRDLKPENILLDAYGHVKLTDFGLCKEEIEGDQK----------THTFCGTIE
AqueK024_Aque LHSNGIIYRDLKPENIMLNGKGHVVLTDFGLSKESLHGEAT----------TNTFCGTIE
** .::******:* :*. **: ******.* . :: ** *
p70S6Kb_Hsap YMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKL--ALPPYL
p70S6K_Hsap YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL--NLPPYL
p70S6Kb_Mmus YMAPEILVRTGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIKGKL--VLPPYL
p70S6K_Mmus YMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKL--NLPPYL
R04A9.5_Cele YMAPEMIRKVGHDHAVDVWALGILMYDMFMGGPPFTGETPADKDKSILKGKV--RLPPKL
S6kII_Dmel YMAPEILTRSGHGKAVDWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKL--NLPAYL
YBR028C_Scer YCAPEILLGKAYSQNCDWYSLGCLLYDMLVGKPPYTGSNHKVIINKIQQNKQGPKIPFYL
p70RSK_Spur YMAPEIVSRSGHGKDVDWWSLGALMYDMLTGGPPFTAENRKKTIEKILKGKL--SLPPYL
Y47D3A.16_Cele YMAPEILMRCGHGKAVDWWSLGALMFDMLTGGPPFTAENRRKTIDKILKGRL--TLPAYL
AqueK024_Aque YMAPEILQRIGHGKAVDWWSLGTLMYDMLTGAPPFCADNRKKTIDRILHGRL--YLPPYL
* ***:: .:.: * ::** *::**: * **: ... . * : : :* *
p70S6Kb_Hsap TPDARDLVKKFLKRNPSQRIG---------------------GGPGDAADVQRHPFFRHM
p70S6K_Hsap TQEARDLLKKLLKRNAASRLG---------------------AGPGDAGEVQAHPFFRHI
p70S6Kb_Mmus TPDARDLAKKFLKRNPTQRIG---------------------GGLGDAADVQRHPFFRHI
p70S6K_Mmus TQEARDLLKKLLKRNAASRLG---------------------AGPGDAGEVQAHPFFRHI
R04A9.5_Cele SASGKDLIKRIIKRDPTLRIT--------------------------IPDIKEHEFFEEI
S6kII_Dmel TPEARDLVRRLMKRQEPQRLG---------------------SGPEDAAAVQIHPFFKHV
YBR028C_Scer SEGMKDILNALLKKETAKRWNVDKYWAKTGANNKPTKSKKKKSGAARTSLFTEHFIFRKI
p70RSK_Spur THEARDLVRKLLKRHISARLG---------------------SGPEDATRIRKHPFFRHV
Y47D3A.16_Cele SNEARDLIKKLLKRHVDTRLG---------------------AGLSDAEEIKSHAFFKTT
AqueK024_Aque TADAKDIIKKLLKRHPPNRLG---------------------SGPEDNKPIKEHRFFKMI
: :*: . ::*:. * . * :*.
p70S6Kb_Hsap NWDDLLAWRV----DPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDT------ALSES-A
p70S6K_Hsap NWEELLARKV----EPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDS------TLSES-A
p70S6Kb_Mmus NWDDLLARRV----DPPFRPSLQSEEDVSQFDARFTRQTPVDSPDDT------ALSES-A
p70S6K_Mmus NWEELLARKV----EPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDS------TLSES-A
R04A9.5_Cele DWDKLMAHDF----EPPFKPTLANLEDVSHFDESFTSIAPEESPCKA------ITTYTHV
S6kII_Dmel NWDDVLARRL----EPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDT------TLSES-A
YBR028C_Scer DWKLLESGQLQKTTLGPIVPVITDLELAENFDTEFTSMSYEETYTDSKPININSVSK-SP
p70RSK_Spur KWDDVLARKG----EPPITPAVVNEEDVSQFDSKFTKQTPVDSPDDS------MLSES-A
Y47D3A.16_Cele DWNLVYARQL----EAPFKPNIENDEDTSLFDARFTKMTPVDSPCET------NFSLN-G
AqueK024_Aque NWEDLFNQKV----EPPFKIPVRGDDDVSQFDTKFTTLLPVDSPVDT------TISAS-A
.*. : *: : . : .. ** ** :: .: :
p70S6Kb_Hsap NQAFLGFTYVAP-SVL--------------------------------------------
p70S6K_Hsap NQVFLGFTYVAP-SVL--------------------------------------------
p70S6Kb_Mmus NQAFLGFTYVAP-SVL--------------------------------------------
p70S6K_Mmus NQVFLGFTYVAP-SVL--------------------------------------------
R04A9.5_Cele LELFLLFFSMSP-EENGRILNKNKNQSKVMPNLNVKSDMVLTEEEIKKYNGKVLALHRLL
S6kII_Dmel NLIFQGFTYVAP-SIL--------------------------------------------
YBR028C_Scer -DMFKGFSYKASGSYL--------------------------------------------
p70RSK_Spur NQIFLGFTYVAP-SVL--------------------------------------------
Y47D3A.16_Cele DNPFVGFTYVAP-SVL--------------------------------------------
AqueK024_Aque DMNFKGFTYIAD-SFL--------------------------------------------
* * : .
p70S6Kb_Hsap -----------------DSIKEGFSFQPK-----------------------LRSP----
p70S6K_Hsap -----------------ESVKEKFSFEPK-----------------------IRSP----
p70S6Kb_Mmus -----------------DSIKEGFSFQPK-----------------------LRSP----
p70S6K_Mmus -----------------ESVKEKFSFEPK-----------------------IRSP----
R04A9.5_Cele SNKVKKYRKLDENVDYIEFVQKGFMYLLSIGRQEYNKNAMNRSNEFEWKIPKLEEPENIQ
S6kII_Dmel -----------------EDMHRANRM--P-----------------------ARSP----
YBR028C_Scer -----------------E------------------------------------------
p70RSK_Spur -----------------ESMHQKVHHFTK-----------------------VRSP----
Y47D3A.16_Cele -----------------EMMNKGGHGGIS----------------VA---HLASSM----
AqueK024_Aque -----------------EDVYSHSVSSPS-----------------------SYR-----
:
p70S6Kb_Hsap ------------------------------RRLN--SSPRAPVSPLKFSPF-----E--G
p70S6K_Hsap ------------------------------RRFI--GSPRTPVSPVKFSPG-----DFWG
p70S6Kb_Mmus ------------------------------RRLN--SSPRTPISPLKFSPF-----E--G
p70S6K_Mmus ------------------------------RRFI--GSPRTPVSPVKFSPG-----DFWG
R04A9.5_Cele DVNLFEETEPEKFTKGYIKEELPDKICSTVRKV--IKIPRSALEKVGVRLHD-----DEQ
S6kII_Dmel ------------------------------RRTPR-QLPDSSFR-LQFPSA-----NV--
YBR028C_Scer ------------------------------------------------------------
p70RSK_Spur ------------------------------RKIPGSISPRSAISPAKTPQT-----QFA-
Y47D3A.16_Cele ------------------------------SRAGAAKSPRKPGDPETASILHGGHSNLFG
AqueK024_Aque ------------------------------NRP--LRSPHKHLSPVTTETN-----QVFG
p70S6Kb_Hsap FRPSP-------SL----------------------------------------------
p70S6K_Hsap RGASA-------ST----------------------------------------------
p70S6Kb_Mmus FRPSP-------GP----------------------------------------------
p70S6K_Mmus RGASA-------ST----------------------------------------------
R04A9.5_Cele -KPTHLLSDDIKTEPIEEATHVNVIQTPSWKPKFQCISDLLKDDTTDFDCEMSLGSSVLF
S6kII_Dmel -GAN---------APLA-------------------------------------------
YBR028C_Scer ------------------------------------------------------------
p70RSK_Spur -------------------FDEDLLTKPS----------------------------SSR
Y47D3A.16_Cele HGPNS-------EAPQA--FGYGIGSQMT----------------------------TTT
AqueK024_Aque FNAPS---------PLT----------------------------------------VSS
p70S6Kb_Hsap ------PEPTE------LPLPPLLP-----------------------------------
p70S6K_Hsap ------ANPQT------PVEYPMETSGIEQM-----------------------------
p70S6Kb_Mmus ------PEPME------PSLPPLLPS----------------------------------
p70S6K_Mmus ------ANPQT------PVEYPMETSGIEQM-----------------------------
R04A9.5_Cele DRPDS-SLPIKKICPGF-----------PKK----ATEVGGRAEGAVHGWFSYKSYHLIY
S6kII_Dmel ------MHGHS------Q------RSGMFAR-----------------------------
YBR028C_Scer ------------------------------------------------------------
p70RSK_Spur AAPSS-ARPIQ------PIEEAMDTS-----------DG--ASN----------------
Y47D3A.16_Cele AGGAGIQQPYQSFSGGYPEDDAMDTSTPRASESRETTTGNGSTT----------------
AqueK024_Aque TAASSLLYTQ---------S-----------TIMEETSG--NST----------------
p70S6Kb_Hsap ------------------------------------------------------------
p70S6K_Hsap -----------------------------------DV-----------------------
p70S6Kb_Mmus -----------------------------------PP-----------------------
p70S6K_Mmus -----------------------------------DV-----------------------
R04A9.5_Cele TKLIMIMGSIPSNKRIMSESQVRRELNASFARNCHPTAIGMQKLSERCGIRYKTIFDNFE
S6kII_Dmel --------------------------------A--TP-----------------------
YBR028C_Scer ------------------------------------------------------------
p70RSK_Spur --------------------------------AT--------------------------
Y47D3A.16_Cele --------------------------------TTRPS-----------------------
AqueK024_Aque --------------------------------MIKAP-----------------------
p70S6Kb_Hsap ------------------------------------------------------------
p70S6K_Hsap ------------------------------------------------------------
p70S6Kb_Mmus ------------------------------------------------------------
p70S6K_Mmus ------------------------------------------------------------
R04A9.5_Cele TIRKDGKIECETNDACCRIREFLSRETDTTSYIEITNEVQTVLEDEIELHLLSRKRFTLG
S6kII_Dmel ------------------------------------------------------------
YBR028C_Scer ------------------------------------------------------------
p70RSK_Spur ------------------------------------------------------------
Y47D3A.16_Cele ------------------------------------------------------------
AqueK024_Aque ------------------------------------------------------------
p70S6Kb_Hsap ----PPPPSTTAPLPI--RP---PS-G-------------------------------TK
p70S6K_Hsap ----TMSGEASAPLPI--RQ---PNSG-------------------------------PY
p70S6Kb_Mmus ----SPPPTSTAPLPI--RP---PS-G-------------------------------TK
p70S6K_Mmus ----TVSGEASAPLPI--RQ---PNSG-------------------------------PY
R04A9.5_Cele YVHVIMEKTDLAPSYI--RA---QYENWRRKLSTKDRGSWKIGDSEAGLNKYFAKNNKPG
S6kII_Dmel ----PHHMQTFAPR--P------S-PA-------------------------------QD
YBR028C_Scer ------------------------------------------------------------
p70RSK_Spur --------------------------------------------------------A---
Y47D3A.16_Cele ----NVGSSASTPIPLPKRVIKLPHTH---T-------------------------S-TQ
AqueK024_Aque ----VVNGSDHSHIPLLK-GINSIRTN---E-V----------------------DK-GN
p70S6Kb_Hsap K-----------------------------------------------------------
p70S6K_Hsap K-KQ-------------------------------------AFPM--------------I
p70S6Kb_Mmus K-----------------------------------------------------------
p70S6K_Mmus K-KQ-------------------------------------AFPM--------------I
R04A9.5_Cele V-RQREKIAKKLGLSERQVRNYFNKKRITERKLKVWKDAPKDFLTLSKQTVDEMMKIAEE
S6kII_Dmel E-----------------------------------------------------------
YBR028C_Scer ------------------------------------------------------------
p70RSK_Spur ------------------------------------------------------------
Y47D3A.16_Cele NAQY-------------------------------------SFML--------------L
AqueK024_Aque LVSP-------------------------------------GFNLKLS----------PP
p70S6Kb_Hsap SK---------------------------R-GRGRPGR
p70S6K_Hsap SK---------------------------RPEHLRMNL
p70S6Kb_Mmus SK---------------------------K-GRGRSGR
p70S6K_Mmus SK---------------------------RPEHLRMNL
R04A9.5_Cele RRKPNDEYIQIANRLGVSHITLCSFIDWQKSIYAGKAK
S6kII_Dmel MM---------------------------D-VQGLPMV
YBR028C_Scer -----------------------------------KYF
p70RSK_Spur -------------------------------AKTSGYR
Y47D3A.16_Cele LL---------------------------NVSLFFHFF
AqueK024_Aque AN---------------------------RP-AHLGLS