BCK1_Scer WMKGEMIGKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQ--------------------
SSK2_Scer WQKRNFIGGGTFGRVYSAVDLDNGEILAVKEINIQDSK----------------------
SSK22_Scer WQKRSFIGGGTFGQVYSAINLENGEILAVKEIKIHDTT----------------------
STE11_Scer WLKGACIGSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQ
6622_Tthe AQVGELIGQGAYGRVYKGFVKSTGKFIAIKEMKEEMMLG---------------------
7147_Tthe YKKCELIDKGAYGKVYKGIDTITNQVVAIKYIEITGT-F---------------------
11359_Tthe FKKGHIIDRGSYGEVYQCLEVNTGQLYAIKTIRKNKD-K---------------------
15684_Tthe ---DKILGKGTFGTVVLGHNKNTGEIVAVKLIETQYD-R---------------------
18758_Tthe WKSGDFIGAGSFGQVFTAMNCNTGEIFVVKKIMVHGQ-S---------------------
23105_Tthe VELRELLGEGAYGKVYKGFIKKTGKFIAVKQLKLGLKDN---------------------
29763_Tthe WQSGEVLGTGSFGQVILGMNIDTGEFMAVKQVHIGGYNQ---------------------
MEKKalpha_Ddis WQKGQILGRGGYGSVYLGLNKDTGELFAVKQLEIVDINSD--------------------
CC1G_12014_Ccin WIKGALIGAGSFGKVYLGMDASNGLLMAVKQVELPQGDG---------------------
CC1G_10524_Ccin WIRGELLGKGSYGRVYLALNATTGEVMAVKQVELPKTPSD--------------------
CC1G_13687_Ccin WQQGRFIGAGAFGSVYLAMNLDSGSLMAVKEIKFQELS----------------------
CC1G_10513_Ccin WVRGELIGKGTYGRVYLALNATTGEMIAVKQVELPQTPSD--------------------
GK078_Glam YSLGRIIGHGSFGQVYLALEHLTGKLLAVKEMVVKNCS----------------------
:. * :* * .. . .:* :
BCK1_Scer --------------N--EAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKN--NIYSLF
SSK2_Scer ------------------SMQKIFPLIKEEMSVLEILNHPNIVSYYGVEVHR--DKVNIF
SSK22_Scer ------------------TMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHR--DKVNIF
STE11_Scer QEKIEDVGAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEG--GNLNIF
6622_Tthe -----------------EDAHSLLESICKEIQLLKQLSHKNIVNYIGSKKQE--GSVYIY
7147_Tthe -----------------EEVKKEINSLKKEIVLLKKLNHQNIVKYYDFEISDDKSGVDII
11359_Tthe -----------------AVLEKEVQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGINII
15684_Tthe --------------------KQKYKSIIDEVKILKQMRHKNIVRYYGIQEHKAKDHIGIV
18758_Tthe -----------------KLDKEFLDEQEKELRIMQTLSHKHIIQYKGHERQQ--DCLCIF
23105_Tthe -----------------NKLQEKLEQYLQEIALLNHLEHPNIVKYYDCKHEE--DNILIY
29763_Tthe -----------------KDRQEKIQQIQSEIEALRNFSDKNIVRYIGIKKSE--TSINIF
MEKKalpha_Ddis -----------------PKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQ--SFLSVF
CC1G_12014_Ccin --------------PSQERKKSMLSALEREIELLKVLQHENIVQYLYSSSDD--EYLNIF
CC1G_10524_Ccin --------------KMKPQQLDVMKALKFEGDTLKDLDHPNIVSYLGFEESQ--DYLSIF
CC1G_13687_Ccin ------------------GLPNLYAQIKDELSVMEMLHHPNVVEYYGIEVHR--DKVYIF
CC1G_10513_Ccin --------------RNDSRQNTVVQALKLESETLKDLDHPHIVQYLGFEETP--ANLSIF
GK078_Glam --------------------REVLEAIDAETRILINLRHPNIVNIYDIEVSDDGNKLLIV
* : . ::: . :
BCK1_Scer LEYVAGGSVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMK---------AD
SSK2_Scer MEYCEGGSLAALLEHGRIEDEMVTQVYTLQLLEGLAYLHESGIVHRDVK---------PE
SSK22_Scer MEYCEGGSLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIK---------PE
STE11_Scer LEYVPGGSVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIK---------GA
6622_Tthe MEYMPGGSISEMLKKYGGFDEEVIQKFVKQLLEGLIYLHSKGVIHRDLK---------GA
7147_Tthe LEYVPNGSLRMALNKQRCFDETKAAIYTKQVLEGLDYLHKNNIIHRDLK---------GA
11359_Tthe LEYVSGGSIRQMLDKFGKFNEKVISIYTNQVLQGLKYLHSNHVFHRDIK---------GG
15684_Tthe CEYVSGGSLWRLIQKFGKFSEPLIRKYTTDILYGLQYLHYHGITHRDIK---------GA
18758_Tthe LEYMSEGNIDQMLKKFGPLEEQTIKVYARQILSGIQYLHSQKVIHKDIK---------GA
23105_Tthe MEQMPGGSLSSMLEKFGRFEEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGA
29763_Tthe LEYVPGGSISSLLYRYGKFNETLIRKFTQQILKGLEYLHAHEIIHRDIK---------GA
MEKKalpha_Ddis LEYIPGGSISSLLGKFGAFSENVIKVYTKQILQGLSFLHANSIIHRDIK---------GA
CC1G_12014_Ccin LEYVPGGSVATLLSNYGAFEEPLVRNFVRQILQGLSYLHERDIIHRDIK---------GA
CC1G_10524_Ccin LEYVPGGTVGSLLVKNGRLREEVTKSWLRQILQGLDYLHGKGILHRDLK---------AD
CC1G_13687_Ccin EEYCQGGSLAALLEHGRIEDERILQLYTVQMLDGLSYLHSQGIVHRDIK---------PD
CC1G_10513_Ccin LEYVPGGSIGSCLHKHGKFSENVTKSFTGQILSGLEYLHSKGILHRDLK---------AD
GK078_Glam MDFIAGGSLASLSKSFKGIPEILCRRYARQILEAIKHMHRQNVAHLDLK---------CS
: *.: * ::: .: .:* : * *:*
BCK1_Scer NLLLDQDGICKISDFGISRKSKDI--YS-------------------------------N
SSK2_Scer NILLDFNGVIKYVDFGAAKKIANN--GTRLASMNKIENADGEHEDVTHVSDSKAVKNNEN
SSK22_Scer NILLDFNGIIKYVDFGTARTVVGS--RTRTVRNAA----------------VQDFGVETK
STE11_Scer NILIDIKGCVKITDFGISKKLSPL--NK-----------------------------KQN
6622_Tthe NILSDGQGNVKLADFGAARNIENI-LQH-S-------------------------LSQSE
7147_Tthe NLLLDAEGRAKLTDFGTAKQIEFD-LRK-SQVK--E-------------------EDIAK
11359_Tthe NILIDTDGTIKLTDFGTLKLHKKD-AYI-NHSK-SQ----------------SQLSHNQL
15684_Tthe NILVDSDGVCKLADFGLAKSISQE-IDE-------------------------------G
18758_Tthe NILVGSDGIVKLSDFGCAKQLELT-LNS-----------------------------NKE
23105_Tthe NILTDGNGTVKLADFGAARYRDTI-CLP-T-------------------------ADGSE
29763_Tthe NVLVDKDGNCKLADFGSAKKIVEE----------------------------------KG
MEKKalpha_Ddis NILIDTKGIVKLSDFGCSKSFSG--IV--------------------------------S
CC1G_12014_Ccin NILVDNKGGVKISDFGISKKVDDN-LLG----------------------------GNRL
CC1G_10524_Ccin NILVDHSGVCKISDFGISKKAGEI--NR-----------------------------A-K
CC1G_13687_Ccin NILLDQLGRIKFVDFGAAKILAKN--QHTLQRSRRST-------DAA----FNAANGIGV
CC1G_10513_Ccin NILVEMTGICKISDFGISKRTDDL--HG-------------------------------G
GK078_Glam NIMIGGDGLVKLVDFGTATRLARDDIINELQRRKETE-ADPKKPG------L-PSEAAKK
*:: * * ***
BCK1_Scer SDMTMR-GTVFWMAPEMVDT-K-QGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVV---AA
SSK2_Scer ALLDMM-GTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEMITGRRPWANLDNE---WA
SSK22_Scer SLNEMM-GTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNE---WA
STE11_Scer KRASLQ-GSVFWMSPEVVKQT---ATTAKADIWSTGCVVIEMFTGKHPFPDFSQM---QA
6622_Tthe FCNSIK-GSLYWMAPELIKNE---KHGRRIDVWSLGCTVIEMASAQHPWENIKKF---SD
7147_Tthe MNKSLK-GTPNWMAPEVIERT---GHTTSADIWSIGCIVIEMITGKPPYPGLSAK---EV
11359_Tthe DYGTIQSQKPFWTAPEVLKNED--SHDASSDIWSVGCLVIEMITALPPYYNLNDKSS-QE
15684_Tthe QLKLPQ-GTPNWMAPEVCRS----GTCRFSDIWSLGCTVYEMITGKPPFSNFLAE---TI
18758_Tthe MNKTLK-GSVPWMSPEIVTQT---KYDTKADIWSFGCTILEMAQAEAPWSNYQFDNPIAA
23105_Tthe FCNSIK-GSLYWMAPELLNQE---SHGRKSDIWSLGCTMIEMATGKHPWPDCRTF---PQ
29763_Tthe HNDSIR-GTPYWMAPETIKQL---GSG------SIGCTVIEMATAKPPWADKSPI---QA
MEKKalpha_Ddis QFKSMQ-GTPYWMAPEVIKQTG-HG--RSSDIWSLGCVIVEMATAQPPWSNITEL---AA
CC1G_12014_Ccin HRPSLQ-GSVFWMAPEVVKQT---GHTKKADIWSVGCLVVEMLTGEHPWAQLTQM---QA
CC1G_10524_Ccin AHTGMK-GTSFWMAPEILSPGE-KGYDVKVDIWSVGCVAVEMWTGKRPWYGHEWW---PV
CC1G_13687_Ccin MSNGLT-GTPMYMSPEMIKNDR-RGRHGATDIWSLGCVILQCATGRKPWSNLDNE---WA
CC1G_10513_Ccin AFTAMQ-GTVFWMAPEVINTQK-KGYNFKIDIWSVGCVVLEMWGGRRPWTGQEMV---TV
GK078_Glam FNLGIK-GSPYWIAPECVRSTL-YD-IFKADIWSIGCLFIEMFTTYPPFFQFKQV---PA
. : :** : ** : *:
BCK1_Scer -MFKIGKSKSAPPIPEDTLPLISQIGRNFLDACFEI----------------------NP
SSK2_Scer IMYHVAA-GHTPQFPTKD--EVSSAGMKFLERCLIQ----------------------NP
SSK22_Scer IMYHVAA-GRIPQLPNRD--EMTAAGRALLGKVFGS----------------------RP
STE11_Scer -IFKIGTN-TTPEIPSW----ATSEGKNFLRKAFEL----------------------DY
6622_Tthe -LANAVIEQQPIPIPQH----LSEECKDFISKCCT----------------------YDK
7147_Tthe -FTKIASG-----------------------GCLQ----------------------TDP
11359_Tthe -ITKYIMDGNIPNFPEK----LSEQCLEFLQKTLK----------------------VNP
15684_Tthe -ILRVGLLKQPPQFLENL--QISEKLSDFLLHCFQ----------------------IKP
18758_Tthe -IMKIGLSDEIPQIPET----ISPDLNQFIRKCLQ----------------------RDP
23105_Tthe -LALIVKTNQCPPIPEH----LSDECKDFIRQCCT----------------------FDK
29763_Tthe -MFYIANAQQPPPIPEH----LSPVCKDFISKCLKYQNQIELVDLTKTQQILFLQFRINP
MEKKalpha_Ddis VMYHIASSNSIPNIPS----HMSQEAFDFLNLCFKR----------------------DP
CC1G_12014_Ccin -IFKIGSS-ARPTIPSD----ISAEAQDFLQKTFEI----------------------NH
CC1G_10524_Ccin -LMKVAEDKSPPPIPEDI--PMGHLAQSFHNQCFRP----------------------DP
CC1G_13687_Ccin IMFHIGVSTQHPPLPEPG--QLSPLGIDFIKQCLTI----------------------DP
CC1G_10513_Ccin -MFKLYEAKLPPPVPDDV--VLSELGDDFRRKCFAIFMTDG--------------ACSNP
GK078_Glam LLYHIATITEPPGLPE----TMSDEGRDFLSKCLQI----------------------NP
:
BCK1_Scer EKRPTANELLSHPFS
SSK2_Scer SKRASAVELLMDPWI
SSK22_Scer H------------YE
STE11_Scer QYRPSALELLQHPWL
6622_Tthe KMRPKSQQLFNHPFL
7147_Tthe KKRLTTSQLLKTPFI
11359_Tthe KERATVNELIQLKFI
15684_Tthe EERWNVDQLLQHPFI
18758_Tthe SKRPTATELLNDSFL
23105_Tthe KERPTADVLLKHPFL
29763_Tthe NDRYNVRQLLNHPFI
MEKKalpha_Ddis KERPDANQLLKHPFI
CC1G_12014_Ccin ELRPHAAELLQHPWL
CC1G_10524_Ccin ADRPHASVMLKHPYL
CC1G_13687_Ccin TFRPSAKELMDHPWM
CC1G_10513_Ccin DERPPAAELRLHPYL
GK078_Glam EARASVDDLLAHPWV
: