BCK1_Scer MPFLRKIA----G--TAHT-----------------------------------------
SSK2_Scer MSHSDYFNYKPYGDS----------T-----------------------EKPS--SSKM-
SSK22_Scer MMMDILNTQQQKAAEG-------GRV-----------------------LAPHTISSKLV
STE11_Scer MEQTQTAEGTDLLIGDEKTND---LPFV---------------Q----------------
6622_Tthe MSMFDKEYDKK-GFD--------I-------------------------KQIQSPILKL-
7147_Tthe MGCGASNHKGEVA-------------------------------------EPRS------
11359_Tthe MGICGAKMKI-VA-------------------------------------EPVQ------
15684_Tthe MGSSFSNSCAKSK-------------------------------------QK-K------
18758_Tthe MKNQEFNNSAQKSS------------------------------------TYKLPIKKN-
23105_Tthe MRTYKFIIDQKIDEN--------L-------------------------KVLKKEEAKL-
29763_Tthe MGNNLLNACKNTS-------------------------------------APTD------
MEKKalpha_Ddis MSWLNNPSQ-NF-VD----------P----------------------------------
CC1G_12014_Ccin MGSVDLRGQLPFPTGPTISLD---PPPGTTFAESLKAWTDNHVA----------------
CC1G_10524_Ccin MDSRPASTLRT-L-----------------------------------------------
CC1G_13687_Ccin MRKHNPTLYTLSERDSDDINDDDENV-----------------SWQHEEHDPV-PGPS--
CC1G_10513_Ccin MSEDVRNGKIH-G--RKYF-V---------------------------------------
GK078_Glam MGVGASSVPGNATSEHIDGS----------------------------------------
*
BCK1_Scer ------------------------------------------------------------
SSK2_Scer RQSSSSSSSR-LRSESLGRNSNTTQARVASSPISPGLHSTQYFRSP--------------
SSK22_Scer KRLSSHSSHKLSRSDLKA------------------------------------------
STE11_Scer --------------------------LFLEE-IGCTQYLDSFIQCNLVT-----------
6622_Tthe YQN---------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe SMGS-------------------T--------IGCWI--SSAKRKNFLFT----------
23105_Tthe HQGN-------------------N-------KISLIV--NNH-IQQFEIKATLPFSNRSN
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis -----------------------------------------FIRIKCIL-----------
CC1G_12014_Ccin --------------------------RWLSD-MKCGMHAEVF-RINDIR-----------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin NVSASSNLNRSVRSSLKGRQSS--------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer -------------------------------------------------------NAV--
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------EEEIKYL---------------DK
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ---------------------------------------------TGKT--PE-------
15684_Tthe ---------------------------------------------EN----KS-------
18758_Tthe ----------------------------------------REIPFSEDT--PNQMNK---
23105_Tthe FKPPLYRGNAHLLVANGKKNHSLSIHHPHHFHLNNNGNHLKVIPTTNKK--PKNLNSN--
29763_Tthe ---------------------------------------------QND---GD-------
MEKKalpha_Ddis ------------------------------------GDDIRIIKFNSNISYGGLMNQLEQ
CC1G_12014_Ccin ------------------------------------GDVLLEL---------------DQ
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------A---------------NR
GK078_Glam ------------------------------------------------------------
BCK1_Scer --HSRSDSNS--------------------------------------------------
SSK2_Scer --------YS----PGE------------------------------------SPLNTVQ
SSK22_Scer ------------------------------------------------------------
STE11_Scer DILIALGVNK----IGDRL----------------------------------KILRKSK
6622_Tthe -AKQEINNKS-----D-NIFSPSLNSQNIQSS--------------------KKIY--QH
7147_Tthe -----------------RFIFL--NA--------------------------------IQ
11359_Tthe ------------------------NN--------------------------------RQ
15684_Tthe -----------------NMISP--EQ--------------------------------MQ
18758_Tthe --------IE-----G-KKTIF--NR--------------------------KTT---IQ
23105_Tthe -NNNSINNIS-----I-NH--SNSNSINLQSNIPNSFHRPQSPVVLNISSDRHNLY--QQ
29763_Tthe -----------------NDQT----Q--------------------------------KE
MEKKalpha_Ddis DFQCPISIHQYEDYEGDKVTVK--SKDDIMEALTMYFE--------------LKALNPTK
CC1G_12014_Ccin DTLKEMNIVS----IGDRI----------------------------------RILNAVK
CC1G_10524_Ccin QT--------------W-------------------------------------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin GSDSENDSDD----DNDKP----------------------------------PIFNSYH
GK078_Glam ------------------------------------------------------------
BCK1_Scer -------------------------------SVKFG--HQPTSS----------------
SSK2_Scer LFNRL--------------------PGIPQGQFFHQ--NA--------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer SFQRDKRIEQVNRLKN--------------------------------------------
6622_Tthe QL-QPLQLV--------------------------------------QKDDQK-------
7147_Tthe QF-QQFRLE--------------------------------------QKENQV-------
11359_Tthe KK-QKQ------------------------------------------------------
15684_Tthe NK-ESSNLT--------------------------------------QKLDN--------
18758_Tthe QK--QNQLQQ-Q-----------------------------------QVQQQT-------
23105_Tthe QQ-QQYSFQH-------------------------------------QAHNQI-------
29763_Tthe KQ-EKRKLE--------------------------------------RKKNQR-------
MEKKalpha_Ddis IISTKFFLKQ-LPPQ-----------------------SQPLSSSLSPTQSLILNNNNNN
CC1G_12014_Ccin LLRQRAAARTPSPIHV----------------------TRPTAS---------------H
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin YSAPYHSKPPPTDPYDHHPPALRTDLGS---SYVQDHNHRPSLS----------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer --------------VASTKSSSKSPRATSR----------KS------------------
SSK2_Scer --------------ISGSSS-SSARSSRRPSNIGLPLPKNPQQSLPKLSTQPVPVHKKVE
SSK22_Scer --------------LGGSET-I----S---------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis SNNNLMNMNMNMNLNMN-SNNSSGSSSSNN--IVI--PQQQG------------------
CC1G_12014_Ccin TRTGS--ENLSLEQGVASGRGHSRKESTRP--PPI--TIHPN------------------
CC1G_10524_Ccin --------------------AVPFRETVP-------------------------------
CC1G_13687_Ccin -------------------------HS---------------------------------
CC1G_10513_Ccin --------------SPSSLSSHAADESTPP----------PP------------------
GK078_Glam ---------------------------------LLPVPQLERDKL---------------
BCK1_Scer IYD--DIR---------------S-----------------------QFPN---------
SSK2_Scer ASKT--ESEIIKKPAPVNSNQDPLLTTPTLVISPELASLNTTNTSIMSTPQNITNQTSNK
SSK22_Scer -----------------------------------------------DGPSQL-------
STE11_Scer ---------LMEKV----------------------------------------------
6622_Tthe --------EHKKKPQ------------------------------------SIQ------
7147_Tthe --------QKNK------------------------------------------------
11359_Tthe ------------RQN------------------------------------NI-------
15684_Tthe --------NIQD-MN------------------------------------T--------
18758_Tthe ---------IQN-SN---------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe --------NKSD-FG------------------------------------S--------
MEKKalpha_Ddis NRKGSNAPP-LRTPPPSPPSS---------------------------------------
CC1G_12014_Ccin ANKG-DLPDLIREPPPDSASGRSM-----------------------MAP----------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin -----------------------------------------------KVPTNVN------
CC1G_10513_Ccin TPGV-SLP---------------L-----------------------ASPP---------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ---------------------------------------LTPNSTSSQFYESTPVIEQSF
SSK2_Scer HIPTRSQPNGSTSSSTLQDIVTTNSSQRSVGHHGGSTTSLRTYKKQYVLNEQLYLRKMRN
SSK22_Scer -----------------------------------------TFKDRYVFNESLYLKKLKK
STE11_Scer ------------------------------------------------------------
6622_Tthe ---------------SSDR-----------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------SPKNS-
CC1G_12014_Ccin -------------------------------------------PPVR----PLPVPQNAT
CC1G_10524_Ccin -----------------------------------------------------PVP----
CC1G_13687_Ccin ---------------TKQDIY-------------------SQFVKRYRTKEHRYVDEMED
CC1G_10513_Ccin ---------------------------------------TIPAKPVHPLHEALPINDRHY
GK078_Glam ------------------------------------------------------------
BCK1_Scer ---NWTTDDHISA-G-TLENP-TSFTNSSYKNDNGP------------------------
SSK2_Scer ---RAND-DYYTRGIV-ASSN--------FEDDE--E-----------------------
SSK22_Scer ---TALD-DYYTRGIK-LTNR--------YEEDDGDD-----------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ---PTASQ-VSTPEP-GITHAL-----KRIYMGFTLQTLQINVSVAAASGPARRLGGHPY
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin FRSDPDS-HYYHKGLGQLVDV--------GDASDDED-----------------------
CC1G_10513_Ccin ---PDVH-QTSARGG-TVTNMLTNL--RNWRHGSTPRT----------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------SSLSD------------SRKSSGG
SSK2_Scer -------------------------------------NFSNKGEDDLELEMDDLLKVE-G
SSK22_Scer -------------------------------------EIIRLS--------------N-G
STE11_Scer ----------------------------------SSLST--------------ATLSMNS
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin AMPSVQATLHPPTGLQNPNLSPIDEHFAAAGQNSSSTSTPSPPSQPYRSYTPAN----AY
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin -------------------------------------YMSLIG--------------G-N
CC1G_10513_Ccin ---------------------PVEASAARRPRTSPSVSTPD------------SAVSSNS
GK078_Glam -------------------------------------------------------GL---
BCK1_Scer NSVN-------------------------SL-------------S---------------
SSK2_Scer EDKDNDFNFGYNFITSSTKNNENVVSMSLNYLKGKLDWLRDVNNDQPCEIEDEEWHSILG
SSK22_Scer DRIDEDLHSGVKFFSTTPYC-------------------RKMRSD---------------
STE11_Scer E----------------------------LI-------------P---------------
6622_Tthe --ILSKDYSKGKIF----------------------------QIQ---------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin NTPS------------------------LDD-------------I---------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin DGIIEG--------------------------------------S---------------
CC1G_10513_Ccin N----------------------------LP-------------N---------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer -FD---KLILS-W-DPTDPDEWTMHRVTSWFKFH----DFPESWIL-FF--------KKH
SSK2_Scer SEDLLSKLL--Q--NPMVN-----------------------------------------
SSK22_Scer -SD---ELA--W--NEIAT-----------------------------------------
STE11_Scer -EK---HCVIFI-LNDGSA---KKVNVNGCFNADSIKKRLIRRLPH-ELLATNSNGEV--
6622_Tthe -KD---EM----------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin -RK---KIVKFVIPEEGTS---YMIDVTNCSSGQEVIEKVLKKIGKGGFRGIDNDGHGD-
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin -MD---EMAHPV--TEKDQ-----------------------------------------
CC1G_10513_Ccin -PD---KILICVT-TEADPERLNIVDVSGAKDATSIRESILSKVPY-SFSAVSSSILTRH
GK078_Glam ------------------------------------------------------------
BCK1_Scer QLFGHRFIKLLAYDNFAVYEKYLPQTKTASYTRFQQLLKKTMTKNVTNSH----------
SSK2_Scer -----------------------------NRFEWQTMLSKVLKGDIVRNEKTKIANQGKG
SSK22_Scer -----------------------------ERFKWQSMLARVLKGDIVKGEKTRIANQVKK
STE11_Scer ---------TKMVQDYD-------------------------------------------
6622_Tthe ----------------------------------------------------------SG
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ----------------------------------------------------------HN
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin -----RDDGSLNVDGWA-------------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin -----------------------------RRLEWQSLLSSVLSGEVLKSEKTRLAVALDS
CC1G_10513_Ccin -----QTNLLDGLNRYS-------------------------------------------
GK078_Glam ------------------------------------------------------E-----
BCK1_Scer ---------I------------------------------------------RQKSA-SK
SSK2_Scer PGFN-TQFSD------------------------------------------DIWIE-LK
SSK22_Scer PGLN-KELSD------------------------------------------EIWLE-LK
STE11_Scer ---------V------------------------------------------F--VLDYT
6622_Tthe FA--INNFNNNN-KL----------------SAFQSYPQSPTYKDQFNC-KLQ-------
7147_Tthe ----------------------------------------------------K-------
11359_Tthe --------NQ------------------------------------------Q-------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe NS--NNNNNNNNNNTNNNCNNVGLGGNFGQLGFMRDRPQR---KNRHNSIKLI-------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ---------V------------------------------------------Y--LASGE
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin FGDEQNNFNM------------------------------------------NIWLG-IR
CC1G_10513_Ccin ---------I------------------------------------------Y--LTEIG
GK078_Glam ------------------------------------------------------------
BCK1_Scer LKSSRSSSES-----IKSKLKNSKSQ------EDISNSRSTSESAL--------------
SSK2_Scer AWMNGRTVED-----QNKSLRIFRD-STDSVFQEIMAFKLEDN--M--------------
SSK22_Scer AWLNGRTMQE-----MEQSLTYLRD-SSDSVFEEIMKFQIPQGKIL--------------
STE11_Scer -KNVLHLLYDVELVTICHA-----------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin -ESPSEPLTETQLLNICNA-----------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin AKFHGRSIEE-----EKRKLDEKRIRIVDGVIDEIMNFRVVQDEAA--------------
CC1G_10513_Ccin ASVIGDPLNDERLLDLVQRQGDSRGT------LKFFVSRSTKEQIPPPPQQMPPPFPFPY
GK078_Glam ------------------------------------------------------------
BCK1_Scer --SPTK----------------------S----------GPSKTDE----------KNFL
SSK2_Scer ---SADEAAETIKSLVDKYYRVLNLWPNI-----KRMHAEKPITKT----------EAFR
SSK22_Scer ---SLDALEAILQDLMNRYHSVVSYWPNL-----KKMYKDKPITNT----------AEFT
STE11_Scer ---NDR----------------------VEKNR---------------------------
6622_Tthe --------SKQSEET-------------------------------------PTQK----
7147_Tthe --------NKQSEDV-------------------------------------V-------
11359_Tthe --------NKLGEE----------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe --------KQKAEHS-------------------------------------VSSK----
29763_Tthe ---------VHAEDI-------------------------------------IEKK----
MEKKalpha_Ddis --------------------------------------------------------PPFL
CC1G_12014_Ccin ---PDH----------------------PARERGLAVRRLRRQEDRSGSPLA--------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ---PTNSAMKQVTNILHRLDVAQSLYPHL-----KAFYLDKPKAQE----------GPFQ
CC1G_10513_Ccin VEQPTH----------------------PA---ILPLRPRRRPRSRQGSVSSVSSEQPAE
GK078_Glam ------------------------------------------------------------
BCK1_Scer -------HSTSTHQKTKSASSLYRRSFISLRGSSS-SNASSAKSPSNIKLSIP-ARPHSI
SSK2_Scer N-------RIDTLNSWLNFKFNFDTNIAYLKKWIVGNKELES------------------
SSK22_Scer A-------RIDVMNSWLNFKTNLTLRRQELDDWINRFSPIS-------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis -------GNNS-------NTSINILDFYSLNGSNN-NSGGTG------------------
CC1G_12014_Ccin ----RNLQPPT-QPTSKATKRASSISILSGLGVRN-------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin A-------RCDALNTWFTILSSLKRHLTRLRRWTGSDS-LDV------------------
CC1G_10513_Ccin LGYDADLDNPDDSRKSSRQQNHSSRSHLTGPGISP-PSPGPLRRPPNGPLPIAPLGPPSA
GK078_Glam ------------------------------------------------------------
BCK1_Scer IES-----NSTLT--KSASPPASPS-YPSI-FRRHHKSSSSESSLLNSLFGSGIGEEAPT
SSK2_Scer ---TTEVDNTTVNL-DDPAV-FAT-NCKRF-AEQIMKEKDIEL-----------------
SSK22_Scer -----SSDNCQEDF-DGVPQ-WNC-KMKIL-AEQLMKEKNIES-----------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ---------------------------------------Q--------------------
23105_Tthe ---------------------------------------Q--------------------
29763_Tthe ---------------------------------------E--------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ---NHPNPNSEITVTSQGSV-EHP-DGTSF-VERLLKEESMQR-----------------
CC1G_10513_Ccin SHSNYPHPPSPI---SQGHV-SKPPTPPTFFHDRPHLPSASRSTYI--------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer KPNPQGHSLSSENLAKGKSKHYETNVSSPLKQSSLPTSDDKGNLWNKF----------KR
SSK2_Scer -IFQKKI-FFPLAPWILKAKFFFLKYQKTWNELNLSYLDQDLEFLLMFPMRLVKDIILIR
SSK22_Scer -IFQKKI-FYPLSPWMFKLKLHFIVYRETLTKMNIKYPYERLRSLLAFPVYLIKEVILTR
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin -TFEKGF-LVTVHAFLGTVRDAHVNLAAQLKEMNLPTFENELVPLISFPTKLAQASLRLR
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer KSQIGVPSPNTVAYVTSQETPSLKSNSS-TATLTVQTAD--V-------NIPSPS---SS
SSK2_Scer LSYAKKIQN-PTLMMIDQMMDDFSTYIKLAVQMKFTVAS--Y-------CN-----DWFF
SSK22_Scer LSYARKLKN-PTMMMIDQMIDDFNAFIRLSVQLKYTLTK--Y-------CS-----NLPF
STE11_Scer ------------------------------------------------------------
6622_Tthe ---------------------------------SQNQPLYRLPN--N-------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------P-----------------
18758_Tthe -----------------------------GASLSVLQSG--Q-------ALPKL------
23105_Tthe -----------------------------ISSINILQSH--NPNYQKHNIIPSLIESPIT
29763_Tthe -----------------------------I------------PR----------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin -------------------------------------PD--K-------VLGD-------
CC1G_10524_Ccin -----------------------------------DLPG--R-------LLPQP------
CC1G_13687_Ccin LDYVGKLEPDVDVLIIDQMTEDLKLNIGLACTLKRQYQA--F-------LAPDPDGNWAL
CC1G_10513_Ccin -----------------------------------DKYG--Q-------VLPAPP---P-
GK078_Glam ------------------------------------------------------------
BCK1_Scer PPPIPKTANR-------------------------------SLEVISTEDTPKISSTTAS
SSK2_Scer KVKID-------------------------------------------------------
SSK22_Scer DVDFD-------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe --------------------------EANPF-------K---DG----------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe KSSHNHNNHSNINGNFSSNDHTSDLDKANNS----SNTN---NGT---ISNINI------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ---SSSPHNS--------------------------------------------------
CC1G_13687_Ccin PPCIS-------------------------------------------------------
CC1G_10513_Ccin PPPLSSPRRGDF------------LDEPNSSLSPLAHIRSGS------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer FKETYPDCINPDKTVPVPVNNQKYSVKNFLLDQKFYPLKKTGLNDSENKYILVTKDNVSF
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer -------------------------------------------------LIFVSKDQT--
6622_Tthe -----------------------------------------------NQ-LQIQNDNIKA
7147_Tthe ----------------------------------------------------IQ-----D
11359_Tthe --------------------------------------------------LNNSKKDE--
15684_Tthe ------------------------------------------------------------
18758_Tthe ---------------------------------------------------KIQNDS---
23105_Tthe -----------------------------------------------SN-IQIMNNSSSN
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis --------------------------------------------SNNNGIGSSSREIT--
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin -----------------------------------------DAGAEREQ-LLIASEQAEA
GK078_Glam ------------------------------------------------------------
BCK1_Scer VP-LNLKSVAKLSSFKESALTKLGINHKNVTFHMTDFDCDIGAAIPDDTLEFL-------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ---------------------------------------------PSDK-----------
6622_Tthe IKLE----------------------------------------SDQK------------
7147_Tthe LDAQ----------------------------------------EDIRT-----------
11359_Tthe ---------------------------------------------KAHK-----------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe NNTN----------------------------------------SNQN------------
29763_Tthe ---Q----------------------------------------EEQSD-----------
MEKKalpha_Ddis ---------------------------------------------PPLR-----------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin A--------SQQRRRRDASLTRLRA------------------EPSRDNLSLLSRNRKPT
GK078_Glam ------------------------------------------------------------
BCK1_Scer -----------------------KKSL---------------------------------
SSK2_Scer ------------PEFDHTVVEGLEYFFSILELRILYSGKNSFKTSKEPDLLLKYWEMFRN
SSK22_Scer ------------PTFENTVIEAIRYLFFLLNLKLIDSSKQNF---KAPDLLLKYWDHLKN
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------SISQ----------------LQSP------------------
7147_Tthe ------------------VVSQ----------------LKE-------------------
11359_Tthe ------------------IQSS----------------QKN-------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ---------------------V----------------NNAA------------------
23105_Tthe ------------------GNSS----------------SQNY------------------
29763_Tthe --------------------SS----------------SQQM------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ------------EDYDSTILEALTQFFKLLHWKLKSGVKGIY--LKETDVLEAQWATYND
CC1G_10513_Ccin PTDPNDWTFINPPDTNIPVTEPLRSGEPIWPTKTLASS----------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ----------------------------------------------------FLNTSGKI
SSK2_Scer VGYYIDDAGELIAAEFTKLTLRLVHRLHAYLLRQQNTPPKLENE----------------
SSK22_Scer TGHYINGAETVIPNEFLKLTLRLVHKLQFYLLKQQNFPPTFANA----------------
STE11_Scer ----------------------------------------------------AISTSKKL
6622_Tthe -------------------------------------RVRIKT-IQK-NMK---------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe -------------------------------------------------QQ---------
18758_Tthe -------------------------------------NQNLGESSTAEKAV---------
23105_Tthe -------------------------------------NNSNNQ-NQN-NSI---------
29763_Tthe -------------------------------------NGFDGQSYQS-NEI---------
MEKKalpha_Ddis ----------------------------------------------------TPPGSP--
CC1G_12014_Ccin -----------------------------------------PP-----------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin VSLT-AGGSSLVAEHLCSLTNKLMVRVTNYFDTQVRVPLSDKQS----------------
CC1G_10513_Ccin ----------------------RGHRSQMFARVPKQPPQSLPSSSTESRSSSSRSASKPI
GK078_Glam ------------------------------------------------------------
BCK1_Scer YIKDQMKLQQKPKPAPLTSENNVPLKSVKSKSSMRS----------------GTSSLIAS
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer YLRTL-----------------------SALSQVGP----------------SSSNLLAQ
6622_Tthe ------------------------------SPTYQNLN-----------KEKLSQNDLA-
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------NLSINN------------------------
18758_Tthe ------------------------------EEQERK----------------KPQGFVE-
23105_Tthe ------------------------------SSSFQNIGGHQNNFPISTESNRNSINNLS-
29763_Tthe ------------------------------NSTYNQ----------------GSENHLN-
MEKKalpha_Ddis -------------------------------------------------------RFALN
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin --------------------------------AL--------------------------
CC1G_13687_Ccin ---------------GNQS-NG------------GP----------------VTSSAPSS
CC1G_10513_Ccin YLPKAVHS-KPPDSYPKGTSSTVPLKSLGKGKSM--------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer TDDVSIVTSSSDITSFDEHASGSGRRYPQTPSYYYDRVSNTNPTEELNYWNIKEVLSHEE
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe --------------DFENQQNQ--------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe --------------KIR-------------------------------------------
23105_Tthe --------------SINNNNNI--------------------------------------
29763_Tthe --------------KMRKS-----------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer NAPKMVFKTSPKLELNLPDKGSKLNIPTPIT-----EN------ESK-SS------FQ-V
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer -------------------------------------NKGISHNN-AEGK------LR-I
6622_Tthe -------------------NGEKIKTEQNKIDNEGQF---QVQNE-E-EQ------IS-P
7147_Tthe -------------------------------------------------L------IF-I
11359_Tthe -------------------------------------------------V------IV-Q
15684_Tthe --------------------------------------------K-QEET------IV-P
18758_Tthe -----------------------------QLKNVNAK---QVEND-QQQN------IN-V
23105_Tthe -------------------NNSCSNTNHNNKSNLSSY---KRQEK-K-YRISKTQILF-P
29763_Tthe -----------------------------------QH---NKYSK-KNRH------IV-N
MEKKalpha_Ddis -------------------------------------NSNSNSNS-SVNN------IP-T
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin -------------------------------------D------N-A-------------
CC1G_13687_Ccin -------------------------------------NSGKASSDA-TTSG-----QRLT
CC1G_10513_Ccin -------------------------------------D------N-L-RQ------FS-Y
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------LR-K-DE--GT-EIDFNHRR----
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------DN-TEKD--RI-RQIFNQRP----
6622_Tthe ------------------------------------IK-NKIN--KI-QSINAIIPEKY-
7147_Tthe ---------------------------------------------------IYT------
11359_Tthe ------------------------------------AN-SKIN--K--------------
15684_Tthe ------------------------------------TS-PKTQ--K--------------
18758_Tthe ------------------------------------NN-SKVN--KL-QSPATTMAF---
23105_Tthe FNSKENICDPESQNAAQNSSSKNNTSNACNQNQSNHNSSQKIN--NI-------NNSHYG
29763_Tthe ------------------------------------NL-VNGQ--N--------------
MEKKalpha_Ddis ------------------------------------NN-NNNNHHHIIHQLNLNSPS---
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ------------------------------------D-----------------------
CC1G_10513_Ccin ------------------------------------NS-SKAP--TI-KPPHPQLPS---
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe -----------L--------------------PKTPSGEKFHQKQESSRP----------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ----------------------------------------T-------------------
18758_Tthe ---------RSL------------------------------------------------
23105_Tthe SNSNNLHALKLI--------------------SHN--------------PKIVNNQNFEE
29763_Tthe ----------------------------------------Q-------------------
MEKKalpha_Ddis ---------PPPPLRTPP------------------------------------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ---------RPPVVREPVYLAAGSFGVPKSYEP---------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe --------------KHNEDI----------------------------------------
23105_Tthe DVILFNKAISQPTEVLREQMALGTPPQLAAYTTSATTDTIHRQSFRIKHYNLSSRQSSRG
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------PRAIRPLPVQGSHYPQSPDANSRS
GK078_Glam ------------------------------------------------------------
BCK1_Scer -------ESPYTKPELAPKREAPKPPAN---------T---SP-Q-------RTLSTSKQ
SSK2_Scer ---------------------A--------------------AAEKWLVQIFEILGSMKR
SSK22_Scer ---------------------S--------------------EAEKWLSSIFENLGAMKR
STE11_Scer -------PSEFISTNL--AGYFPHT-----------------------------------
6622_Tthe ----------SSG-----------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe GLKSTQTSDPISSL----------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis -------P--------SPPSSSP-PSSSPQSSFIFEQTDFHFE-E-------LS--KNNS
CC1G_12014_Ccin ----------------SPSNEAPSPPPP--P----------LW-Q-------SGAGNAKR
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ---------------------G--------------------QIINWYSKILDGVRLRYR
CC1G_10513_Ccin GFPSYGKPSPYMPTPL----------STNLTSPNRDMYGRDHP-P-------RPLSASD-
GK078_Glam ------------------------------------------------------------
BCK1_Scer -------------NKP----------------------IRLV-RASTKISRSKRS-----
SSK2_Scer --KLNRFTNILTKAF----------------------------QNFVRYKIED-H-----
SSK22_Scer --KLNRFSNILVKAF----------------------------QNSAVYQINH-N-----
STE11_Scer --DM--------------------------------------------------------
6622_Tthe -----RNQNF-----I----------------------IKMV-NNHNYSDVNH-I-----
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe -----QTHNN-----IGESISQSNTNNNTNQLYYELGDLSPC-NKHQNPPQYH-YHHNNF
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis PKNS---NFLNTIDQP----------------------HQIYQPH---------------
CC1G_12014_Ccin PSKL---RNFFGQRPP----------------------SELITDH---------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin --KLQRFARVLTQRF----------------------------SNSAEYSIDD-V-----
CC1G_10513_Ccin -------------------------------------------NHTTSPTYSQR------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ---------------------KPLPPQLLSSPIEASSSSPDSLTSSYTPASTHVLIPQPY
SSK2_Scer ---------------------N--------------------------------------
SSK22_Scer ---------------------A--------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ---------------------H--------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe NQNNFPYNYNFNQKSSSNINSS--------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis -------------------------------------------------------QPHYQ
CC1G_12014_Ccin -------------------------------------------------------LPEFF
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ---------------------AM-------------------------------------
CC1G_10513_Ccin --------------------------------------------SNQSPSYGGTMS----
GK078_Glam ------------------------------------------------------------
BCK1_Scer KGANDVMR----RLKTDQDSTST-S-P---------------------------------
SSK2_Scer --------YLLKQLKETG-HFLIYTGGYLEQNGTYLIGSPELLGCKDDDILRIIKNSDIG
SSK22_Scer --------QLVKKLKDAH-YFLVYSGNTFESSGVYMFAAPELLGCDNDTILRILRNKSIG
STE11_Scer ------KR----LQKTMRES----------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis QQQ--QQQ----QMYNFNQ---------------------PLSP-SPPL-QSQQKQQ---
CC1G_12014_Ccin PMA--EKK----VLRTARHSILLRS-GTLKRQSALSGGSIQLPP-PPPL-PSRFSTS---
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin -------DHLINLLVLTD-HFLVYT-QTMEEESIYIVASGSLYD-RPDLIRRILVE-AFH
CC1G_10513_Ccin --------------------------P----SRSYG-----IGG-PRTL-----------
GK078_Glam --------------------------AAVDQSGISLLAAGDN------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer CDLVPK-----------------------------LEINNSLTIY--NALDDNWNSNSSL
SSK22_Scer CDLVPK-----------------------------LDIGNNLNVY--DITTKETDLNILV
STE11_Scer ------------------------------------------------------------
6622_Tthe --------------------------------------NNNLNNA--NNGS---------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe --------------------------------------QLYLNNY--EDHEEEDE-----
23105_Tthe --------------------------------------NNNINNAHLNYGS---------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis -----QQ-----------------------------------------------------
CC1G_12014_Ccin -----TQGSGCRRSMSPGRASITSL---PPPPLPEK------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin VDEI--------------------------------------------------------
CC1G_10513_Ccin ------------------------LHHSGHSDRSSD------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer GSDISNDGTPFYYI-KNDLT---TQPR-SYNGNRVNREPDFENSRSTEEEFYELETRLNS
SSK22_Scer SKGEDSKGIPYYRVVANSSSDLDRHAH-QSKKKNFSTDPFDQHLDEKNNEVFELEVALSS
STE11_Scer ------------------------------------------------------------
6622_Tthe ----------------------N-TV-IRLQSKEISDT----------------------
7147_Tthe ---------------------------IKI------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ----------------------E-EIEYKI------------------------------
23105_Tthe ----------------------N-HV-NNQQGRILSSR---------------SANKISQ
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ----------------------------------DEGEPI--------------------
CC1G_10524_Ccin --------------------------------------P---------------------
CC1G_13687_Ccin --------------------------A-SEEGG----------VRAVSADY--LLHDSDE
CC1G_10513_Ccin ----------------------------------VPSGPETSNSTPPRTPISPVSCKSSP
GK078_Glam ------------------------------------------------------------
BCK1_Scer SLKMKQKVNRSNS-TVSTSNSI------------------------FYSPSPLLK-----
SSK2_Scer LGYV-LVLTPQEP-LLWEGEMYNLSDNKTIKPE--GLNLKVIPNSIDLMCQGSSYALEYQ
SSK22_Scer LGAL-VVLYPGEP-VVWDGPVYKLPGNNLFASNEMDLGKIGNPNTLILLNQGSNYALTYQ
STE11_Scer ------------------------------------------------------------
6622_Tthe -------------PKS--------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe NMIKKIIRQPSTHIQSEEGNS-IIRRGN-IQ-----------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ------------------------P--RM----SL----STDDGH---------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin VGYL-LVLTPHTP-FIWHGRVMFVPVPNI----SL----DLKEGRIRLIADGSYGRLNYA
CC1G_10513_Ccin AGKMPLVIEPSSP-ASDSGNATYIS--NV----SS----VDSEKTIREDDKTQLA-----
GK078_Glam ------------------------------------------------------------
BCK1_Scer --------RGNSKRVVSSTSAADI-------------------FEENDITFADAP-----
SSK2_Scer CDRFQ-------------------------------------------------------
SSK22_Scer IDKFN-------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe --------------------------------------QNR----------EEKYQES--
7147_Tthe ---------------------------------------------------ESKFSPS--
11359_Tthe --------------------------------------Q--K--------MQKNNAKS--
15684_Tthe --------------------------------------Q--E--------EKQVCNIS-N
18758_Tthe --------------------------------------N--R--------EDTQFSD--E
23105_Tthe --------------------NNKLNQQVNAIVRKNSYWQNQREQLERKKKKEKSMISS--
29763_Tthe --------------------------------------Q--K--------EEDKFSHS--
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin -----------------------------------------------------S------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin KQVFSDCME---------------------------------------------------
CC1G_10513_Ccin --------ALLN--------------------------------NMNALMSSDRLPVSAS
GK078_Glam ------------------------------------------------------------
BCK1_Scer ----------------P----MFD---SDDSDDDS---SSSDDI----------------
SSK2_Scer ---------------------QIS---G-SS----------VSFLEKKSSSETVKNNL--
SSK22_Scer ---------------------QTV---G-DS----------VSFIEKRCSLNSIESSL--
STE11_Scer ------------------------------------------------------------
6622_Tthe YNEIKDR----ID-TQ---NSQQIGDSLQNLDEE--------------------------
7147_Tthe KGNILA--------N-------------QNLDGS--------------------------
11359_Tthe DSQLEA--------N-------DQCSQIQDLDGI--------------------------
15684_Tthe EIQLEK--AAPVTPQI--------------------------------------------
18758_Tthe SA------NSPNKSNKFQLSSSDASNGLQSTNGKS------INLLQQK------------
23105_Tthe NNDVTETHHTIIAAQQ---NQQTEPFSIDDQEEE--------------------------
29763_Tthe ES--EH--PSPKQGGE---NAEKEADSLQITYFY--------------------------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ---------------ID----L-H---SDDDDDDI---PL--------------------
CC1G_10524_Ccin ----------------D----YSD---SDDDD--S---IW--------------------
CC1G_13687_Ccin ---------------------LVE---G-DDDNSGVEPLYLTCLVETQAHLPSVNREL--
CC1G_10513_Ccin ETSMAV---------ND----LSS---SDESDYEG---SGGTWIKPYQDRPPSARPELTK
GK078_Glam ------------------------------------------------------------
BCK1_Scer IWSKKKTAPE-------TN-----------------------------------------
SSK2_Scer -------------------------------------------------QRINKAYFRCT
SSK22_Scer -------------------------------------------------QKINKAYYKLT
STE11_Scer -------------------F---------------------------------RHSARL-
6622_Tthe -----------------QK-----------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe --------------KENQA-----------------------------------------
23105_Tthe -----------------NK-----------------------------------------
29763_Tthe -----------------FK-----------------------------------------
MEKKalpha_Ddis -------------------QQQQQQQQQQPQQQQQQQQQQQQQQQQQQQQQF-NNSFENG
CC1G_12014_Ccin --S-ASVAPRLLPPIETGSF---------------------------------SQSME--
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin -------------------------------------------------RKIVRATNRLA
CC1G_10513_Ccin LRTDLPSTPD-------P------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer -----------NE-NKKD------------------E-----------------------
SSK2_Scer YSVLKNYTKIVTTFKKVSPVNDLLNNIFLFGRDFGLNFLRINVANNEKRSIIILLMMRLS
SSK22_Scer YTVLNNYKGILGSFMKQCPGNELLNSIFMFGRDFGRSFLKYNAFSSKRKYVIIFLMVKLG
STE11_Scer --------SIAQR-RPLS-----------------AESN------------------NIG
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------------------
MEKKalpha_Ddis --------GIKLP-RPLS-----------------PTFL------------------NIN
CC1G_12014_Ccin --------EITGS-RPAS------------------RAT------------------SIG
CC1G_10524_Ccin -----------QA-RPRE------------------R-----------------------
CC1G_13687_Ccin ESIVDSVHHVKRSLRGASNSQDLLGNWYLFASEHGAHAHRYMEKSSLARF--NRLLVKLA
CC1G_10513_Ccin -----------AD-KVRE------------------E-----------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------KSDNSST----HSDE---------------------
SSK2_Scer IGWL--------KFLAEDCDPTDQRVFRWCV----TSMEFAM------------------
SSK22_Scer MNWL--------KFLVEECDPTDQRTFRWCV----LAMDFAM------------------
STE11_Scer DILLKHSNAVDMALLQGLDQ----TR-LSS------------KLD---TTKIPKLA----
6622_Tthe -------NE----------------------------------K---QISEQKQNK----
7147_Tthe ------------------------------------------------------------
11359_Tthe --------D----------------------------------GS--EVFQVQMQR----
15684_Tthe -----------------------------------------------NLEEEQFKK----
18758_Tthe -------NT----------------------------------Q---QQEELISVN----
23105_Tthe -------NQ----------------------------------H---LL--FKF-P----
29763_Tthe -------NV----------------------------------I---QVEEIRQLK----
MEKKalpha_Ddis NN-----------------------I-INS------------NLN--------NNN----
CC1G_12014_Ccin SKRL--------SFMSELRS----KRDRSDTASMMTVDEITAEVESRRVSKMPDMS----
CC1G_10524_Ccin ------------------------QPRRSSGQR---------------------------
CC1G_13687_Ccin VSWA--------SFICDDCDPTDRKTFKWTV----NSLEFIM------------------
CC1G_10513_Ccin ------------------------RPNPSASQSQGYQNG----------------GPSSQ
GK078_Glam ------------------------------------------------------------
BCK1_Scer -----------IFYDSQTQD--KM---------ERKMTFRPSPEVVYQNLEKFFPRA-N-
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ----PNSNQNI---S----SKIQS---------L-----------------NYIN-E-ER
7147_Tthe ------------------------------------------------------------
11359_Tthe -------------------SNLQS---------D-----------------GY-------
15684_Tthe -------------------E--NS---------D-----------------AY-------
18758_Tthe ----NSNAKNIDFYKDESKN--NQ---------EEK---------------KTFKNDQDQ
23105_Tthe ----SKD----------------E---------K-----------------QFFIQH-DK
29763_Tthe -------------------N--NN---------D-----------------KY-------
MEKKalpha_Ddis ------------------------------------------------------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin YQLPPPQ----RFPPGNQQH--RDHRVSGFADGDDDWAPRPPPEDVYDRLEEFFPEH-D-
GK078_Glam ------------------------------------------------------------
BCK1_Scer -LDKPIT-----------EG---IASPT-----SPKSLDSLLSPKNVASSRTEPSTPSRP
SSK2_Scer ------------------HMVSGWNILAL----DECQFSSLKQKISECMSLLISHFDII-
SSK22_Scer ------------------QMTSGYNILAL----NVKQFQELKERVSVCMSLLISHFDVM-
STE11_Scer ---------------------------------H--------------------KRPED-
6622_Tthe ELDSSPIEQGQNS---KLK-----------------------DKNNDKQN----------
7147_Tthe ------------------------------------------------------------
11359_Tthe ---------------------------------------------RDR------------
15684_Tthe ---------------------------------------------FTREQ----------
18758_Tthe IIQTKSIRERFSLP-----------------EKPKDSQIPPIKEI---------------
23105_Tthe NIDQANINRRDNSPKLCLNISNNNNLNTINTNNPKSSKRTSIGRISQKQQQLLAHQPVH-
29763_Tthe ---------------------------------------------FTKED----------
MEKKalpha_Ddis ---------------------------------N--------------------------
CC1G_12014_Ccin ---------------------------------NANDLEGWTKVENAASFDTAPTVPAD-
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ------------------QRTK-RNILHI----PDDQFELLKAKVGHCMSLLINHFDIL-
CC1G_10513_Ccin -LDKLVI-----------EANSGGNSPT-----NPEPTTAIPTPVSANATVIMPQHPHR-
GK078_Glam ------------------------------------------------------------
BCK1_Scer VPPDSSYEFIQDGLNGKNKPLNQAKTPKRTKTIRTI--AHEASLARK-------------
SSK2_Scer ---------------------------GAR-SIEVEKINQQARSNL-DLEDV----FDDD
SSK22_Scer ---------------------------GAR-ATEAENGMQQARLNI-DTEEN----IDEE
STE11_Scer -------------------------------NDAIS--NQLELLSV-ESGEE----EDHD
6622_Tthe ------------------------------------IIKEQ------------SQN----
7147_Tthe ------------------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------YIKVQ-------------------
18758_Tthe ----------------------------------------S------------RAN----
23105_Tthe -----------QVQVQQ-------------------NINQQ------------HQQ----
29763_Tthe ------------------------------------Q-----------------------
MEKKalpha_Ddis -------------------------------------------NNN-NNNNN----NNNN
CC1G_12014_Ccin -------------------------------EVEVD--DDEATLAT-EDDED----EDED
CC1G_10524_Ccin ------------------------------------------------------------
CC1G_13687_Ccin ---------------------------GAR-SNMEAKMEKEKQEML-LRSKVVDSRLDEE
CC1G_10513_Ccin ---------------------------RHKKSIRIV--AQEQKRKMNDQTSR----VDPA
GK078_Glam ---------------------------------------------Y-DNYDN----EDD-
BCK1_Scer --------NS--VKLKRQNTKMWGTRMVEVTEN---------------------------
SSK2_Scer MM-------------LQVNSEF---RVQSIMELEERIKRNP-HQTGKVI-------DDSD
SSK22_Scer AT-------------LEINSRL---RLEAIKTLEKTMKRNP-RQMGKVL-------DATD
STE11_Scer FF-----GED--------------------------------------------------
6622_Tthe ---------------------Q---RQESSMMLQTASEKKEINNLKYIIESN------NL
7147_Tthe --------------------------------------------------AN--NIKEDE
11359_Tthe --------------------------------------------------VN--FNNQDY
15684_Tthe --------------------------------------------------QY--LVNEET
18758_Tthe ---------------------S---Q------KDN-----STSQSPSILA------QS--
23105_Tthe ---------------------Q---QQQQLQQIQQIQNKFPQFNLQSQLQSNGQNILNSI
29763_Tthe --------------------------------------------------E-------YY
MEKKalpha_Ddis NN-----NNN-NN-------------IIQHTD----------------------------
CC1G_12014_Ccin DS-----DD---------------------------------------------------
CC1G_10524_Ccin --------------L---------------------------------------------
CC1G_13687_Ccin DFPPCPSGEEGSWYLDGSTRKFWDRVSKALQELEERTVVIP-QYRGKVL-------DDEK
CC1G_10513_Ccin PY-----GQN--AMLRKRNTKMWGSKLEEVTTMQV-------------------------
GK078_Glam --------------------------------------------------------NEDK
BCK1_Scer -HMVSIN-KAK----------------------------NSKGEYKEFAWM----KGEMI
SSK2_Scer KGNKYLV--SL----------------------------ASSISNVSMRWQ----KRNFI
SSK22_Scer QGNKYLL--SL----------------------------ASSLSNVSMRWQ----KRSFI
STE11_Scer ---SDIV--SL----------------------------PTK-IATPKNWL----KGACI
6622_Tthe NQNN-NN----------------------------------SSSNDYLDAQ----VGELI
7147_Tthe NQNN-Q-------------------------------------NIQLKRYK----KCELI
11359_Tthe DRNG-DM-SC-----------------------------RNQETKRVLTFK----KGHII
15684_Tthe QLKE-QI-ELE----------------------------NQMG---KQKWIPGKTDDKIL
18758_Tthe ---E-LE-NSK----------------------------AEASLQKIVKWK----SGDFI
23105_Tthe NQNN-NLFSLNQMSTLLNIKTLSIKKAISNDYSNRHDDIMITGTNPFHDVE----LRELL
29763_Tthe EKKY-YN-EKK----------------------------VQPPKDKNIRWQ----SGEVL
MEKKalpha_Ddis FPSLIIN--EH----------------------------EELISNHNIKWQ----KGQIL
CC1G_12014_Ccin --------DFG----------------------------IAIPTRTNNKWI----KGALI
CC1G_10524_Ccin ---------PY----------------------------QRSFVKPTFQWI----RGELL
CC1G_13687_Ccin LEDRSLV--FL----------------------------ASSSSNISIRWQ----QGRFI
CC1G_10513_Ccin RTSSTIP-ESP----------------------------SSAGSPPTFKWV----RGELI
GK078_Glam RPDR--E--FS----------------------------PPKPRQRHLKYS----LGRII
:
BCK1_Scer GKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQ---------------------------
SSK2_Scer GGGTFGRVYSAVDLDNGEILAVKEINIQDSK-----------------------------
SSK22_Scer GGGTFGQVYSAINLENGEILAVKEIKIHDTT-----------------------------
STE11_Scer GSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIEDV
6622_Tthe GQGAYGRVYKGFVKSTGKFIAIKEMKEEMMLG----------------------------
7147_Tthe DKGAYGKVYKGIDTITNQVVAIKYIEITGTF-----------------------------
11359_Tthe DRGSYGEVYQCLEVNTGQLYAIKTIRKNKD-K----------------------------
15684_Tthe GKGTFGTVVLGHNKNTGEIVAVKLIETQY-------------------------------
18758_Tthe GAGSFGQVFTAMNCNTGEIFVVKKIMVHGQS-----------------------------
23105_Tthe GEGAYGKVYKGFIKKTGKFIAVKQLKLGLKDN----------------------------
29763_Tthe GTGSFGQVILGMNIDTGEFMAVKQVHIGGYNQ----------------------------
MEKKalpha_Ddis GRGGYGSVYLGLNKDTGELFAVKQLEIVDINS----------------------------
CC1G_12014_Ccin GAGSFGKVYLGMDASNGLLMAVKQVELPQGDGP---------------------------
CC1G_10524_Ccin GKGSYGRVYLALNATTGEVMAVKQVELPKTPSD---------------------------
CC1G_13687_Ccin GAGAFGSVYLAMNLDSGSLMAVKEIKFQELS-----------------------------
CC1G_10513_Ccin GKGTYGRVYLALNATTGEMIAVKQVELPQTPSD---------------------------
GK078_Glam GHGSFGQVYLALEHLTGKLLAVKEMVVKNC------------------------------
. * :* * .. . .:* :
BCK1_Scer ---------NEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKN--NIYSLFLEYVAGG
SSK2_Scer -----------SMQKIFPLIKEEMSVLEILNHPNIVSYYGVEVHR--DKVNIFMEYCEGG
SSK22_Scer -----------TMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHR--DKVNIFMEYCEGG
STE11_Scer GAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEG--GNLNIFLEYVPGG
6622_Tthe ----------EDAHSLLESICKEIQLLKQLSHKNIVNYIGSKKQE--GSVYIYMEYMPGG
7147_Tthe ----------EEVKKEINSLKKEIVLLKKLNHQNIVKYYDFEISDDKSGVDIILEYVPNG
11359_Tthe ----------AVLEKEVQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGINIILEYVSGG
15684_Tthe -----------DRKQKYKSIIDEVKILKQMRHKNIVRYYGIQEHKAKDHIGIVCEYVSGG
18758_Tthe ----------KLDKEFLDEQEKELRIMQTLSHKHIIQYKGHERQQ--DCLCIFLEYMSEG
23105_Tthe ----------NKLQEKLEQYLQEIALLNHLEHPNIVKYYDCKHEE--DNILIYMEQMPGG
29763_Tthe ----------KDRQEKIQQIQSEIEALRNFSDKNIVRYIGIKKS--ETSINIFLEYVPGG
MEKKalpha_Ddis ---------DPKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQ--SFLSVFLEYIPGG
CC1G_12014_Ccin --------SQERKKSMLSALEREIELLKVLQHENIVQYLYSSSDD--EYLNIFLEYVPGG
CC1G_10524_Ccin -------KMKPQQLDVMKALKFEGDTLKDLDHPNIVSYLGFEESQ--DYLSIFLEYVPGG
CC1G_13687_Ccin -----------GLPNLYAQIKDELSVMEMLHHPNVVEYYGIEVHR--DKVYIFEEYCQGG
CC1G_10513_Ccin -------RNDSRQNTVVQALKLESETLKDLDHPHIVQYLGFEETP--ANLSIFLEYVPGG
GK078_Glam ------------SREVLEAIDAETRILINLRHPNIVNIYDIEVSDDGNKLLIVMDFIAGG
* : . ::: . : : *
BCK1_Scer SVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMK---------ADNLLLDQD
SSK2_Scer SLAALLEHGRIEDEMVTQVYTLQLLEGLAYLHESGIVHRDVK---------PENILLDFN
SSK22_Scer SLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIK---------PENILLDFN
STE11_Scer SVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIK---------GANILIDIK
6622_Tthe SISEMLKKYGGFDEEVIQKFVKQLLEGLIYLHSKGVIHRDLK---------GANILSDGQ
7147_Tthe SLRMALNKQRCFDETKAAIYTKQVLEGLDYLHKNNIIHRDLK---------GANLLLDAE
11359_Tthe SIRQMLDKFGKFNEKVISIYTNQVLQGLKYLHSNHVFHRDIK---------GGNILIDTD
15684_Tthe SLWRLIQKFGKFSEPLIRKYTTDILYGLQYLHYHGITHRDIK---------GANILVDSD
18758_Tthe NIDQMLKKFGPLEEQTIKVYARQILSGIQYLHSQKVIHKDIK---------GANILVGSD
23105_Tthe SLSSMLEKFGRFEEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANILTDGN
29763_Tthe SISSLLYRYGKFNETLIRKFTQQILKGLEYLHAHEIIHRDIK---------GANVLVDKD
MEKKalpha_Ddis SISSLLGKFGAFSENVIKVYTKQILQGLSFLHANSIIHRDIK---------GANILIDTK
CC1G_12014_Ccin SVATLLSNYGAFEEPLVRNFVRQILQGLSYLHERDIIHRDIK---------GANILVDNK
CC1G_10524_Ccin TVGSLLVKNGRLREEVTKSWLRQILQGLDYLHGKGILHRDLK---------ADNILVDHS
CC1G_13687_Ccin SLAALLEHGRIEDERILQLYTVQMLDGLSYLHSQGIVHRDIK---------PDNILLDQL
CC1G_10513_Ccin SIGSCLHKHGKFSENVTKSFTGQILSGLEYLHSKGILHRDLK---------ADNILVEMT
GK078_Glam SLASLSKSFKGIPEILCRRYARQILEAIKHMHRQNVAHLDLK---------CSNIMIGGD
.: * ::: .: .:* : * *:* *::
BCK1_Scer GICKISDFGISRKSKDI--YS-------------------------------NSDMTMR-
SSK2_Scer GVIKYVDFGAAKKIANNGT--RLASMNKIENADGEHEDVTHVSDSKAVKNNENALLDMM-
SSK22_Scer GIIKYVDFGTARTVVGSRT--RTVRNAA----------------VQDFGVETKSLNEMM-
STE11_Scer GCVKITDFGISKKLSPL--NK-----------------------------KQNKRASLQ-
6622_Tthe GNVKLADFGAARNIENIL--QHS-------------------------LSQSEFCNSIK-
7147_Tthe GRAKLTDFGTAKQIEFDL--RKSQVKE---------------------EDIAKMNKSLK-
11359_Tthe GTIKLTDFGTLKLHKKDAYINHSKSQS-------------------QLSHNQLDYGTIQS
15684_Tthe GVCKLADFGLAKSISQEI--D------------------------------EGQLKLPQ-
18758_Tthe GIVKLSDFGCAKQLELTL--N----------------------------SNKEMNKTLK-
23105_Tthe GTVKLADFGAARYRDTIC--LPT-------------------------ADGSEFCNSIK-
29763_Tthe GNCKLADFGSAKKIVEE----------------------------------KGHNDSIR-
MEKKalpha_Ddis GIVKLSDFGCSKSFSGI--V--------------------------------SQFKSMQ-
CC1G_12014_Ccin GGVKISDFGISKKVDDNL-LGG----------------------------NRLHRPSLQ-
CC1G_10524_Ccin GVCKISDFGISKKAGEI--NR-----------------------------A-KAHTGMK-
CC1G_13687_Ccin GRIKFVDFGAAKILAKNQH--TLQRSRRST-------DAA----FNAANGIGVMSNGLT-
CC1G_10513_Ccin GICKISDFGISKRTDDL--HG-------------------------------GAFTAMQ-
GK078_Glam GLVKLVDFGTATRLARDDIINELQRRK-ETEAD--PKKPG-----LPSEAAKKFNLGIK-
* * ***
BCK1_Scer GTVFWMAPEMVDT-K-QGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVV---AA-MFKIGK
SSK2_Scer GTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEMITGRRPWANLDNE---WAIMYHVAA
SSK22_Scer GTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNE---WAIMYHVAA
STE11_Scer GSVFWMSPEVVKQ---TATTAKADIWSTGCVVIEMFTGKHPFPDFSQM---QA-IFKIGT
6622_Tthe GSLYWMAPELIKNE---KHGRRIDVWSLGCTVIEMASAQHPWENIKKF---SD-LANAVI
7147_Tthe GTPNWMAPEVIERT---GHTTSADIWSIGCIVIEMITGKPPYPGLSAK---EV-FTKIAS
11359_Tthe QKPFWTAPEVLKNED--SHDASSDIWSVGCLVIEMITALPPYYNLNDKSS-QE-ITKYIM
15684_Tthe GTPNWMAPEVCRS----GTCRFSDIWSLGCTVYEMITGKPPFSNFLAE---TI-ILRVGL
18758_Tthe GSVPWMSPEIVTQT---KYDTKADIWSFGCTILEMAQAEAPWSNYQFDNPIAA-IMKIGL
23105_Tthe GSLYWMAPELLNQE---SHGRKSDIWSLGCTMIEMATGKHPWPDCRTF---PQ-LALIVK
29763_Tthe GTPYWMAPETIKQL---GS------GSIGCTVIEMATAKPPWADKSPI---QA-MFYIAN
MEKKalpha_Ddis GTPYWMAPEVIKQ---TGHGRSSDIWSLGCVIVEMATAQPPWSNITEL---AAVMYHIAS
CC1G_12014_Ccin GSVFWMAPEVVKQ---TGHTKKADIWSVGCLVVEMLTGEHPWAQLTQM---QA-IFKIGS
CC1G_10524_Ccin GTSFWMAPEILSPGE-KGYDVKVDIWSVGCVAVEMWTGKRPWYGHEWW---PV-LMKVAE
CC1G_13687_Ccin GTPMYMSPEMIKNDR-RGRHGATDIWSLGCVILQCATGRKPWSNLDNE---WAIMFHIGV
CC1G_10513_Ccin GTVFWMAPEVINTQK-KGYNFKIDIWSVGCVVLEMWGGRRPWTGQEMV---TV-MFKLYE
GK078_Glam GSPYWIAPECVRSTLY--DIFKADIWSIGCLFIEMFTTYPPFFQFKQV---PALLYHIAT
. : :** : ** : *: :
BCK1_Scer SKSAPPIPEDTLPLISQIGRNFLDACFEI----------------------NPEKRPTAN
SSK2_Scer -GHTPQFPTKD--EVSSAGMKFLERCLIQ----------------------NPSKRASAV
SSK22_Scer -GRIPQLPNRD--EMTAAGRAFLERCLVQ----------------------DPTMRATAV
STE11_Scer N-TTPEIPSW----ATSEGKNFLRKAFEL----------------------DYQYRPSAL
6622_Tthe EQQPIPIPQH----LSEECKDFISKCCT----------------------YDKKMRPKSQ
7147_Tthe G-----------------------GCLQ----------------------TDPKKRLTTS
11359_Tthe DGNIPNFPEK----LSEQCLEFLQKTLK----------------------VNPKERATVN
15684_Tthe LKQPPQFLENL--QISEKLSDFLLHCFQ----------------------IKPEERWNVD
18758_Tthe SDEIPQIPET----ISPDLNQFIRKCLQ----------------------RDPSKRPTAT
23105_Tthe TNQCPPIPEH----LSDECKDFIRQCCT----------------------FDKKERPTAD
29763_Tthe AQQPPPIPEH----LSPVCKDFISKCLKYQNQIELVDLTKTQQILFLQFRINPNDRYNVR
MEKKalpha_Ddis SNSIPNIPSH----MSQEAFDFLNLCFKR----------------------DPKERPDAN
CC1G_12014_Ccin S-ARPTIPSD----ISAEAQDFLQKTFEI----------------------NHELRPHAA
CC1G_10524_Ccin DKSPPPIPEDI--PMGHLAQSFHNQCFRP----------------------DPADRPHAS
CC1G_13687_Ccin STQHPPLPEPG--QLSPLGIDFIKQCLTI----------------------DPTFRPSAK
CC1G_10513_Ccin AKLPPPVPDDV--VLSELGDDFRRKCFAIFMTDG--------------ACSNPDERPPAA
GK078_Glam ITEPPGLPE----TMSDEGRDFLSKCLQI----------------------NPEARASVD
. *
BCK1_Scer ELLSHPFSEVNET-FNFKSTR---------------------------------------
SSK2_Scer ELLMDPWIVQIREI-AFGDDS---------------------------------------
SSK22_Scer ELLIDPWMIQIREI-AFGNSE---------------------------------------
STE11_Scer ELLQHPWLDA--------------------------------------------------
6622_Tthe QLFNHPFLQK--------------------------------------------------
7147_Tthe QLLKTPFILRKKIRR--PLS-------Q------NSL-----------------------
11359_Tthe ELIQLKFIAEPDLIE-LTSE-------Q---YSPNQVKSGMFQSQTSLGFVQREFPNNKN
15684_Tthe QLLQHPFIVDTDIEK--NEK-------SS-TLTRK-------------------------
18758_Tthe ELLNDSFLA---------------------------------------------------
23105_Tthe VLLKHPFLN---------------------------------------------------
29763_Tthe QLLNHPFILGKRLTH--VSQ---PGR-QLPLITEEAT----VDYQTSSPDKRKE------
MEKKalpha_Ddis QLLKHPFIMNLDDNIQLPT------------ISPTT----TL------------------
CC1G_12014_Ccin ELLQHPWLSKKGK-KAA-------------------------------------------
CC1G_10524_Ccin VMLKHPYLEIQSP-WVFNWDDLADNSRP-PRIYPELVP--PV------------------
CC1G_13687_Ccin ELMDHPWMLDLQAA--LEDDG----------L----------------------------
CC1G_10513_Ccin ELRLHPYLELPPG-WTF-------------------------------------------
GK078_Glam DLLAHPWVAMVNLT--FGIHP----------LVPDKP---AV------------------
: :
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ----------------------------VSQE---------------ELLE-Q-------
11359_Tthe GLRIQNDFYNDEPPQFMRDA-------GFFENQDNYNANKNDRNREDESLI-D-------
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ------------------------------------------------FLT-RGESRGNT
MEKKalpha_Ddis ----------------STNTTNTTATTTTTNNATNSNINQQQQQQQQQPPTRT-------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ----------------VRER-------TVTQSTFKANGPPTEKPRAHKPPLEP-------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ---------------SGREA--------------------HLQQSIDAPPSLA-------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe -------------------------IQSIQQGQNIQQEYSRINKGSQPLIKGNSSQSIKV
11359_Tthe -------------------------LKGLSVIQND-KQFKKMTRDNTPLSKNNQQQQ---
15684_Tthe --------------------------------------RN--------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe LFHEENSMKDTLTEKTLVFSVKTKTHKSQKSRKSIRL-RESDGENSQDSIDLGKSKNMNN
MEKKalpha_Ddis ------------------------------------QR-VSISAG-------------SS
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin -------------------------LKIPAYGPTSTQRKPSVNGAGPPVV-----WITPP
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer -----LAK-----------FIKSND-KLNSS-----------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe PQIISNQNA----------------------------------SSQPLIVNK--------
11359_Tthe ----QNYNF----------------------------------EDQIHYIDKIHQKEQLA
15684_Tthe ------------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe PRPLNPQPK----------------------------------MIQ--------------
MEKKalpha_Ddis NN--KRYT-----------PPIST--STSSSSSSILNNFSINIILPINLIILIFREIKPN
CC1G_12014_Ccin -------A-----------AAAAAA-AAASA-----------------------------
CC1G_10524_Ccin NTPRRTAK-----------PEDSSA-STSTSD----------------------------
CC1G_13687_Ccin ---------------EIATSPRPD--TQS-------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam -------TSKADKLLGLFTKTKDTDVTQS-------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ---------------------PNPYLEYQYKNQQKYQEYQDSQ-----------------
11359_Tthe FDNQIKRIMLESKQNF--NEARDEYQQQLM------------------------------
15684_Tthe -----------------------ASIKKQYKKNSSSSSSGDNI-----------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe -----------------------PSIDKNKDNNDNSSKSSDSSRSSSNSSNSQERTKNNT
MEKKalpha_Ddis FVNTLSRVCKHWKQIIDDDELWNKYCSDRLINKSKFEESITWK-----------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin --------AAPW------------------------------K-----------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ------IDQ---LKERTKSL----------------------NRFANEHKSST--QNDKQ
11359_Tthe -------SQ---LKEFE---------------------------------DKT--QQDQN
15684_Tthe ------VNA---LQEQPSKH----------------------ELFINQQQQLSQQQQIVQ
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe QISYTGTDA---MPIRKKQV----------------------TPFSLSHKQSSLNQQ--Q
MEKKalpha_Ddis ------SNY---IKIYKQQKVWFHN----------------------KLNHSTLKGHDKG
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------STSKRRL--------VIVNPDLDDDIGPAPQNTPPKPKFVYTPPPLPDPPQPPY
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe QNQIRKIDQQTNKNINAEDEILQIAKQ---VKRQQ------------EYVQANVNPGYDQ
11359_Tthe QQNQNNVKKQEQK--DVEDEILDLIKK---KKNKRKQGNNAGANTPQQNKNSSTSTFDT-
15684_Tthe QNQQQIVQQNQQSNLTTTFTVN--VKN---NQNKRDSLRTILEESNQQYSGKSPSLFYEE
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe RQQPQSLQIQQPSEYSGTKSVY--T-----SEIDRDKSSII--TKQQSYTSQNSSEGGRQ
MEKKalpha_Ddis VFCVKLIDDQGMVLSGGEDKKLKVWDI---------------------------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ASSPRPLRHAVSTSFASVSSMGSISSKAGSPS----------------RPRALVDPGLSS
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe Y-IF----K---PQVESN--------------VI-------KFS-NKDH-----------
11359_Tthe --SM----QNPPPQVRYQ--------------V--------LFNNPKDNYKFLSQDETIQ
15684_Tthe Y-SFQDNNP---KDPSIQ--------------SIEGQ-KLSVFYNPDQT------NSSIQ
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe NNKLLENNQ---NQLPTN--------------GIKSQERVNSPFKTQNG------NANNN
MEKKalpha_Ddis ----------------------------------------------------------S-
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin T-RTP-------PRPLPNPLSPPLGRSPAPLPV---------LPSPSKR------RGSS-
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe -----------DVHSNNQNDFNP-------------------------------------
11359_Tthe HNEILLKKQYNDIQQP-ELDQSPQASKQNHSQNQVIPLSKFNSLKQQQENQEEAQNKTQE
15684_Tthe A-----------------------------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe Q-----------------------------------------------------------
MEKKalpha_Ddis ------GNHHHNHHSGIVGSISKK-----------------SGLN-------------II
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ------RDRSHTVHT---------------------------------------------
CC1G_13687_Ccin --------------E---------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ----------TIAKN---------------------------------------------
BCK1_Scer --------------------------------------KLR-------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ---------------------------LRSNSRQNTYSQLKIQPDIHANNQNEFNQQRNN
11359_Tthe KNDYIIDNSKVNESSGQIIQQDLHH--VSS-QG-KSLKKVESSE----------------
15684_Tthe ----------------------------KQNIVKEG----------------LENQLYTN
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe ----------------------------QSNINKNGMSHFSNGVTSSANNNNDNNNDGAN
MEKKalpha_Ddis NNNNSNNSNS------------------S-SNSSSS------------------------
CC1G_12014_Ccin --------------------------------------SAA-------------------
CC1G_10524_Ccin --TFDASASKLYEEGNPTAKASVHNLPIS-SSGSRTIRRLPISP-----------QQLNH
CC1G_13687_Ccin --CSG---DS------------------S-TTY---------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam --WFG---KS------------------K-ANLSQSIRNLQAS-----------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe --------SRQ-----------------NTYSQQKGQQPQQPFRSSLVDIKDEDDMDTTE
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------S-----------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe LIRNYDSNSSN-----------------SSNKQNENNQKKQEAPIYVQNIASNNNSQNHN
MEKKalpha_Ddis -----------NSRYLFSLKGHSGCIKSVDYQRQSGSDVSRVFT----------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin --------GRPAT---------------TTTPSMPGSSTPRPLR----------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe -MIRRSQKSLTL-------LKSKYKNLNEASS----------------------------
11359_Tthe -------KKLQI-------LQSDPLSLTSLGI----------------------------
15684_Tthe ----DQK-----------SKGQKYKPVNSNAFL---KDDIEEDQENQQQLPNDNFQ-TSQ
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe LILTQSQQQITLGQKQADRKSQKLRELNDSSSSSSSRPASKSPQPNQNNLPNLSKNSQSK
MEKKalpha_Ddis ---------------------------------------------A--------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ---------------------------------------------PQKSVPDVSIFAFSR
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ----------------------------QGKDNQIASQNEQA--LS----N---------
11359_Tthe ----------------------------GGFDKFNVDHQDQI--LY----N---------
15684_Tthe N---------------------------NGLQDGLLKQQQQQ--IY----N---------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe N---------------------------ASIDKSAIEQKKQE--AA----Q---------
MEKKalpha_Ddis SADFTCKIFSLKTKKTLFTYTNHQEAV---TCINYLGDVENKCITSSLDKTIQLWDAETG
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin DAYHSRHHPSFKSKSNRPLYTSRGSFDSEPEDINGASDNDSVSST----STTHTKHPQRG
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ----------------------------AK------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe -------------YHLNHSQKQNHKSSYEDL------DIE------------LPQESK--
11359_Tthe -------------YKINQ--IQPKKSGRHQRNKTDQIG-------------------QNH
15684_Tthe -------------NTFNINANK--IDEVDGE------DDEENQDSPEKKNKKFQYQQ---
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe -------------KQLI-Y-----IDCYDDE------DEDEE------------------
MEKKalpha_Ddis SCLSTLRGHTGGIYCVKTDQVATHGNGYNHL------------------VVSA---S---
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin ESLLAMRPRTEDVY--------------KDL------------------EAWFPNHD---
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ---------EVPISRNVGRQNSQITISKEQPLQQESVTEEVIETNQSEPQEENEYLKHEN
11359_Tthe NQNEASFFKEVKRDMNGGNRDNLVTYSSKE-IQSDLNIED--------------------
15684_Tthe --------QDQNIPRNQTRSNSKVRIPS---------------KNNIKTKETDEYEEEEN
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe --------EEVQFHFDQTAVDSIMRHQG---------------NQNINNNNTQTYTNKTN
MEKKalpha_Ddis --------VDK-------------------------------------------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin --------LDR-------------------------------------------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam --------IDL-------------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe KVITTKAA----------------------------------------------------
11359_Tthe ------------------------------------------------------------
15684_Tthe DMLNSKCLRGIPTERKYDEIV---------------------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe SEYNRNARKTVDSQQQPSQLVDTTADSFNRDKFGKLRFSKPTSPKQLNTQVSGTNFNNNS
MEKKalpha_Ddis -----------------------TSNVW--------------------------------
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin -----------------------PVDGA--------------------------------
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam -----------------------NEDEL--------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe ------------------------------------------------NVQRMMLNKQ--
11359_Tthe ------------------------------------------------------------
15684_Tthe ------------------------------------------------DVKINAVFEH--
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe FDQIAIDNKTVITDNTNKNKIGSLKQEQVK---EYSKYFGQGQRSRNDDYKTSSIDQH--
MEKKalpha_Ddis -------------DTRSSSKVRSFTQHTEDVLCCYVFD-QKVVTG-----------SCDG
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin -------------DTPASGALEP-RHHRVDVR------------------------KS--
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam -------------D----------------------------------------------
BCK1_Scer ------------------------------------------------------------
SSK2_Scer ------------------------------------------------------------
SSK22_Scer ------------------------------------------------------------
STE11_Scer ------------------------------------------------------------
6622_Tthe ------------------------------------------------------------
7147_Tthe -LA----NKQQKQQQNFIP----------NKY--FEHQNQVINTD---------IAQRER
11359_Tthe ----------------------------------IN-QSNIENI----------------
15684_Tthe -NIS---NLY-KQNSNFIV----------GSKS---------------------------
18758_Tthe ------------------------------------------------------------
23105_Tthe ------------------------------------------------------------
29763_Tthe -I-I---NQYMQQKQNSHN----------NENNNNNNNN-SPYND---------LTRHID
MEKKalpha_Ddis TI-KLWDIGTGKTISTFIPSETRQKNYVWTVQFD---QSKIISSGKTGIIRIWDIYNERD
CC1G_12014_Ccin ------------------------------------------------------------
CC1G_10524_Ccin -I-RMIAKEQNRR-SHNDPASSRRRTML------------------------WNTHM---
CC1G_13687_Ccin ------------------------------------------------------------
CC1G_10513_Ccin ------------------------------------------------------------
GK078_Glam ------------------------------------------------------------
BCK1_Scer -------------------------------------ITSQENKTE
SSK2_Scer -------------------------------------SSTDTEERE
SSK22_Scer -------------------------------------KDQVPILSS
STE11_Scer -------------------------------------------HII
6622_Tthe -------------------------------------------KYS
7147_Tthe NIRIQEQQEFIQDKIKRQQMWEEELKR----ELEYQKQNPPPYLKY
11359_Tthe ----HKNGQYDENNI--NNLSRSSLNRKH--KKENNSNNIFIENFF
15684_Tthe ------------------NQFEFQMPVYE--DYQESSLPSPQKKSQ
18758_Tthe --------------------------------------------EN
23105_Tthe --------------------------------------------GD
29763_Tthe SINI-------------DDYSESQFESYN--SKEARSKQNIITKNY
MEKKalpha_Ddis SRSIGGHHE---------TIFSLQFNN-QKLITGSLDKLVKIWSID
CC1G_12014_Ccin -------------------------------------SSTNDSPSS
CC1G_10524_Ccin -------------------------------EELSSDKRKDSMPRF
CC1G_13687_Ccin --------------------GSLAV------------PTETNSNGS
CC1G_10513_Ccin ----------------------------------------TSFTSD
GK078_Glam ------------------SLFELALPK-EDLSFIVLQHDKILDAGI