View source for Kinase Subfamily NEK10

__NOTOC__
[[kinase classification|Kinase Classification]]: [[Kinase_Group_Other|Group Other]]: [[Kinase_Family_NEK|Family NEK]]: [[Kinase_Subfamily_NEK10|Subfamily NEK10]]

NEK10 is involved in UV radiation response and cilium biology.

====Evolution====
NEK10 has been found in animals and algae, and is single copy in all genomes. It is lost from insects and arachnids, including Drosophila.

====Domain Structure====
Unlike other NEKs, NEK10 has the kinase domain in the middle. Armadillo repeats are present upstream of the kinase domain, which is followed by a long poorly conserved region and then by a conserved region that is not a known domain.

====Functions====
Like other NEKs, NEK10 is associated with cilium biology in multiple species. Mutations in human NEK10 are associated with cilium function in lung <cite>Chivukula</cite> and with Primary Ciliary Dyskinesia <cite>Mutairi</cite>. The worm homolog, nekl-4 localizes to the base of cilia and implicated in microtubule glutamylation and ciliary integrity <cite>Power</cite>. Protein Interaction mapping shows few associated proteins, but one, KIAA0586, is a conserved centrosomal protein that functions in ciliogenesis and responds to hedgehog signaling. Both KIAA0586 and NEK10 are expressed particularly highly in testis.

Human NEK10 is also implicated in the DNA damage response, similar to other NEK subfamilies: UV radiation induces NEK10 to bind Raf-1 and induce MEK1 autophosphorylation, to activate the G2/M cell cycle checkpoint <cite>Moniz</cite>. NEK10 also phosphorylates p53 on Y327F and this enhances its transcriptional activity <cite>Haider</cite>

====References====
<biblio>
#Haider pmid=32561851
#Moniz pmid=20956560
#Chivukula pmid=31959991
#Mutairi pmid=32414360
#Power pmid=33064774
</biblio>