Kinase Family IRAK

Kinase Classification: Group TKL: Family IRAK

This page is in early draft format.

Evolution

IRAKs are found in metazoans, including 4 genes (IRAK1-4) in vertebrates, single genes in flies and worms, and expansions elsewhere. A very large expansion of IRAK genes is also seen in plants.

Domain Structure

Metazoan IRAK genes typically have a N-terminal death domain followed by a kinase domain, though several species have duplicates that lack the death domain or have a second kinase domain.

References

1. Manning G, Young SL, Miller WT, and Zhai Y. The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9674-9. DOI:10.1073/pnas.0801314105 |