Difference between revisions of "Kinase Family AKT"
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[[kinase classification|Kinase Classification]]: [[Kinase_Group_AGC|Group AGC]]: [[Kinase_Family_AKT|Family AKT]] | [[kinase classification|Kinase Classification]]: [[Kinase_Group_AGC|Group AGC]]: [[Kinase_Family_AKT|Family AKT]] | ||
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====Evolution==== | ====Evolution==== | ||
Latest revision as of 05:24, 21 February 2023
Kinase Classification: Group AGC: Family AKT
Evolution
Akt is found across most eukaryotes, usually single copy, but with 3 members in vertebrates, Akt1, Akt2, Akt3. S. cerevisiae has 3 putative Akt or SGK homologs, YPK1/2 and SCH9, though their sequences are not definitively in either family. All three lack the characteristic Akt PH domain and have weakly-predicted C2 domains at their N termini.
Domain Structure
Akt proteins all have an N-terminal PH domain followed by a kinase domain with the typical AGC-group kinase C-terminal extension. The PH domain in Dictyostelium is cryptic, but detectable by remote homology methods.
