Kinase Family Alpha
From WikiKinome
Kinase Classification: Group PKL: Family Alpha
The progenitors of this family are the myosin heavy chain kinases (MHCKs) of Dictyostelium discoideum and the eukaryotic elongation factor 2 kinase (eEF2K) found in most eukaryotes. Several other mammalian genes have been found to be homologous to these, including the channel kinases Chak1 and Chak2, which are multi-pass transmembrane proteins which act as kinases and as ion channels. Crystal structure of the CHAK1 gene [2] shows a PKL fold, and catalytic activity has been demonstrated for many members of this family.
