Difference between revisions of "Kinase Family CCK4"
From WikiKinome
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[[kinase classification|Kinase Classification]]: [[Kinase_Group_TK|Group TK]]: [[Kinase_Family_CCK4|Family CCK4]] | [[kinase classification|Kinase Classification]]: [[Kinase_Group_TK|Group TK]]: [[Kinase_Family_CCK4|Family CCK4]] | ||
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These receptor tyrosine kinases uniquely recognize and signal downstream of extracellular collagen. | These receptor tyrosine kinases uniquely recognize and signal downstream of extracellular collagen. | ||
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====Evolution==== | ====Evolution==== | ||
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====Function==== | ====Function==== | ||
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<biblio> | <biblio> | ||
#Exposito pmid=18697744 | #Exposito pmid=18697744 | ||
</biblio> | </biblio> | ||
Revision as of 05:51, 9 February 2022
Kinase Classification: Group TK: Family CCK4
These receptor tyrosine kinases uniquely recognize and signal downstream of extracellular collagen.
Evolution
TAMs are vertebrate-specific, with three members in tetrapods and four in most fish. A possible TAM has been seen in the invertebrate chordate, Ciona intestinalis.
Domain Structure
TAMS are single-pass transmembrane proteins, with extracellular Ig and FN3 domains, and an intracellular tyrosine kinase domain.
Function
====References===-
- Exposito JY, Larroux C, Cluzel C, Valcourt U, Lethias C, and Degnan BM. Demosponge and sea anemone fibrillar collagen diversity reveals the early emergence of A/C clades and the maintenance of the modular structure of type V/XI collagens from sponge to human. J Biol Chem. 2008 Oct 17;283(42):28226-35. DOI:10.1074/jbc.M804573200 |
