Difference between revisions of "Kinase Family CCK4"
From WikiKinome
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Latest revision as of 05:51, 9 February 2022
Kinase Classification: Group TK: Family CCK4
These receptor tyrosine kinases uniquely recognize and signal downstream of extracellular collagen.
Evolution
TAMs are vertebrate-specific, with three members in tetrapods and four in most fish. A possible TAM has been seen in the invertebrate chordate, Ciona intestinalis.
Domain Structure
TAMS are single-pass transmembrane proteins, with extracellular Ig and FN3 domains, and an intracellular tyrosine kinase domain.
Function
References
- Exposito JY, Larroux C, Cluzel C, Valcourt U, Lethias C, and Degnan BM. Demosponge and sea anemone fibrillar collagen diversity reveals the early emergence of A/C clades and the maintenance of the modular structure of type V/XI collagens from sponge to human. J Biol Chem. 2008 Oct 17;283(42):28226-35. DOI:10.1074/jbc.M804573200 |
