Kinase Family CCK4

Kinase Classification: Group TK: Family CCK4

These receptor tyrosine kinases uniquely recognize and signal downstream of extracellular collagen.

Evolution

TAMs are vertebrate-specific, with three members in tetrapods and four in most fish. A possible TAM has been seen in the invertebrate chordate, Ciona intestinalis.

Domain Structure

TAMS are single-pass transmembrane proteins, with extracellular Ig and FN3 domains, and an intracellular tyrosine kinase domain.

Function

====References===-

1. Exposito JY, Larroux C, Cluzel C, Valcourt U, Lethias C, and Degnan BM. Demosponge and sea anemone fibrillar collagen diversity reveals the early emergence of A/C clades and the maintenance of the modular structure of type V/XI collagens from sponge to human. J Biol Chem. 2008 Oct 17;283(42):28226-35. DOI:10.1074/jbc.M804573200 |