Kinase Family GASK

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Kinase Classification: Group Atypical: Family FJ

The FJ kinases are a recently-emerging family of atypical PKL-fold kinases which function in the Golgi to phosphorylate secreted proteins and sugar residues on glycoproteins and are sometimes secreted. The founding member, Drosophila four-jointed phosphorylates a cadherin substrate on the extracellular domain and is implicated in planar cell polarity.

Distinct subfamilies, Kinase_Subfamily_FJ, FAM20AC and FAM20B are found in bilaterian animals and some in lower animals, and unclassified homologs have also been found in Trypanosomes.