Difference between revisions of "Kinase Family LRRK"
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[[kinase classification|Kinase Classification]]: [[Kinase_Group_TKL|Group TKL]]: [[Kinase_Family_LRRK|Family LRRK]] | [[kinase classification|Kinase Classification]]: [[Kinase_Group_TKL|Group TKL]]: [[Kinase_Family_LRRK|Family LRRK]] | ||
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'''L'''eucine '''R'''ich '''R'''epeat '''K'''inases (LRRK) are intracellular TKL kinases and GTPases implicated in Parkinson's disease. | '''L'''eucine '''R'''ich '''R'''epeat '''K'''inases (LRRK) are intracellular TKL kinases and GTPases implicated in Parkinson's disease. | ||
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====Domain Structure==== | ====Domain Structure==== | ||
LRRKs are usually long proteins, with N-terminal leucine-rich repeats, followed by ROC GTPase and COR domains, and then by a [[Kinase_Group_TKL|TKL Group]] kinase domain. There are two vertebrate genes (LRRK1 and LRRK2), and one homolog in both Drosophila and C. elegans but the family is expanded to 12 in Dictyostelium and 14 in sponge | LRRKs are usually long proteins, with N-terminal leucine-rich repeats, followed by ROC GTPase and COR domains, and then by a [[Kinase_Group_TKL|TKL Group]] kinase domain. There are two vertebrate genes (LRRK1 and LRRK2), and one homolog in both Drosophila and C. elegans but the family is expanded to 12 in Dictyostelium and 14 in sponge | ||
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==== References ==== | ==== References ==== | ||
Latest revision as of 08:09, 9 February 2022
Kinase Classification: Group TKL: Family LRRK
Leucine Rich Repeat Kinases (LRRK) are intracellular TKL kinases and GTPases implicated in Parkinson's disease.
Evolution
LRRK are found in animals and other unikonts, but are lost from most fungi.
Domain Structure
LRRKs are usually long proteins, with N-terminal leucine-rich repeats, followed by ROC GTPase and COR domains, and then by a TKL Group kinase domain. There are two vertebrate genes (LRRK1 and LRRK2), and one homolog in both Drosophila and C. elegans but the family is expanded to 12 in Dictyostelium and 14 in sponge
