Kinase Family LRRK

Kinase Classification: Group TKL: Family LRRK

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Leucine Rich Repeat Kinases (LRRK) are intracellular TKL kinases and GTPases implicated in Parkinson's disease.

Evolution

LRRK are found in animals and other unikonts, but are lost from most fungi.

Domain Structure

LRRKs are usually long proteins, with N-terminal leucine-rich repeats, followed by ROC GTPase and COR domains, and then by a TKL Group kinase domain. There are two vertebrate genes (LRRK1 and LRRK2), and one homolog in both Drosophila and C. elegans but the family is expanded to 12 in Dictyostelium and 14 in sponge

References

1. Manning G, Young SL, Miller WT, and Zhai Y. The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9674-9. DOI:10.1073/pnas.0801314105 |