Difference between revisions of "Kinase Family NDR"
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(Proposed AGC/NDR/RER subfamily for RIM15 and CC1G_14606) |
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| + | [[kinase classification|Kinase Classification]]: [[Kinase_Group_AGC|Group AGC]]: [[Kinase_Family_NDR|Family NDR]] | ||
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| + | The NDR family has the following subfamilies: | ||
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| + | ====[[Kinase_Subfamily_NDR|Subfamily NDR]]==== | ||
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| + | ====[[Kinase_Subfamily_LATS|Subfamily LATS]]==== | ||
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| + | *AGC/NDR/RER? | ||
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HI - my name is Jon Goldberg, a Bioinformatics Scientist at The Broad Institute. | HI - my name is Jon Goldberg, a Bioinformatics Scientist at The Broad Institute. | ||
I would like to propose a new NDR subfamily that would include Baker's Yeast RIM15 and C.cinerea CC1G_14606 currently at kinase.com. | I would like to propose a new NDR subfamily that would include Baker's Yeast RIM15 and C.cinerea CC1G_14606 currently at kinase.com. | ||
| − | AGC/NDR/RER, where RER indicates response regulator domain. | + | AGC/NDR/RER, where RER indicates the response regulator domain. |
It turns out that these kinases are pan-fungal orthologs: I have seen good copies in Dermatophytes, S.pombe, and others. I will provide evidence when I get time. Since they are pan-fungal and have an interesting domain architecture, I think they deserve their own subfamily. | It turns out that these kinases are pan-fungal orthologs: I have seen good copies in Dermatophytes, S.pombe, and others. I will provide evidence when I get time. Since they are pan-fungal and have an interesting domain architecture, I think they deserve their own subfamily. | ||
Latest revision as of 02:59, 6 January 2022
Kinase Classification: Group AGC: Family NDR
The NDR family has the following subfamilies:
Subfamily NDR
Subfamily LATS
- AGC/NDR/RER?
HI - my name is Jon Goldberg, a Bioinformatics Scientist at The Broad Institute.
I would like to propose a new NDR subfamily that would include Baker's Yeast RIM15 and C.cinerea CC1G_14606 currently at kinase.com.
AGC/NDR/RER, where RER indicates the response regulator domain.
It turns out that these kinases are pan-fungal orthologs: I have seen good copies in Dermatophytes, S.pombe, and others. I will provide evidence when I get time. Since they are pan-fungal and have an interesting domain architecture, I think they deserve their own subfamily.
