Difference between revisions of "Kinase Family PSK"
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====Evolution==== | ====Evolution==== | ||
| − | PSK is found in holozoans (animals+choanoflagellates). It is lost from Drosophila. It is duplicated in mammals, giving rise to human PSKH1 and PSKH2. PSKH2 is lost in several lineages, and PSKH1 may be a pseudokinase in primates <cite>Shresta</cite> | + | PSK is found in holozoans (animals+choanoflagellates). It is lost from Drosophila. It is duplicated in mammals, giving rise to human PSKH1 and PSKH2. PSKH2 is lost in several lineages, and PSKH1 may be a pseudokinase in primates <cite>Caenepeel, Shresta</cite> |
====Domain Structure==== | ====Domain Structure==== | ||
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====References==== | ====References==== | ||
| + | <biblio> | ||
| + | #Caenepeel pmid=15289607 | ||
| + | #Shresta pmid=32053275 | ||
| + | </biblio> | ||
Revision as of 21:46, 19 March 2023
Kinase Classification: Group CAMK: Family PSK
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Evolution
PSK is found in holozoans (animals+choanoflagellates). It is lost from Drosophila. It is duplicated in mammals, giving rise to human PSKH1 and PSKH2. PSKH2 is lost in several lineages, and PSKH1 may be a pseudokinase in primates [1, 2]
Domain Structure
Functions
References
- Caenepeel S, Charydczak G, Sudarsanam S, Hunter T, and Manning G. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11707-12. DOI:10.1073/pnas.0306880101 |
- Shrestha S, Byrne DP, Harris JA, Kannan N, and Eyers PA. Cataloguing the dead: breathing new life into pseudokinase research. FEBS J. 2020 Oct;287(19):4150-4169. DOI:10.1111/febs.15246 |
