Kinase Family PSK

Kinase Classification: Group CAMK: Family PSK

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Evolution

PSK is found in holozoans (animals+choanoflagellates). It is lost from Drosophila. A mammalian-specific dupication gives rise to human PSKH1 and PSKH2. PSKH2 is lost in several lineages, and PSKH1 may be a pseudokinase in primates [1, 2]

Domain Structure

PSKs have an N-terminal myristoylation signal embedded in a short conserved domain, followed by another conserved motif and a CAMK-group kinase domain.

References

1. Caenepeel S, Charydczak G, Sudarsanam S, Hunter T, and Manning G. The mouse kinome: discovery and comparative genomics of all mouse protein kinases. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11707-12. DOI:10.1073/pnas.0306880101 |
2. Shrestha S, Byrne DP, Harris JA, Kannan N, and Eyers PA. Cataloguing the dead: breathing new life into pseudokinase research. FEBS J. 2020 Oct;287(19):4150-4169. DOI:10.1111/febs.15246 |