Kinase Family PVR
From WikiKinome
Kinase Classification: Group TK: Family PVR
These growth factor receptors signal during angiogenesis and other tissue growth responses. In humans, it consists of three subfamilies:
Evolution
PVRs are found many metazoans, including insects and vertebrates, and maybe in nematodes. Within the vertebrates, it appears that a tandem triplication of a single PVR gene gave rise to the founding members of the Kit, PDGFR, and VEGFR subfamilies, which then later expanded during the whole genome duplications early in vertebrate evolution[1].
Domain Structure
PVRs are transmembrane receptors containing a signal peptide, followed by an array of immunoglobulin repeats, a transmembrane region, and a kinase domain.
