Kinase Family Trbl
From WikiKinome
Kinase Classification: Group CAMK: Family Trbl
Trbl ("tribbles") is a family of pseudokinases involved in protein interactions and ubiquitination.
Evolution
Trbl is found throughout animals. Nematodes have a highly divergent member, originally classified as Other-Unique. Vertebrates have 3, TRBL1, TRBL2, TRBL3.
Domain Structure
Trbl has a divergent kinase domain, followed by a COP1 degron, and a unique C-terminal tail.
Functions
Modulation of CEBP function is conserved in C. elegans, helping to define the highly divergent gene nipi-3 (K09A9.1) as a member of the Trbl family [1, 2].
References
- Kim KW, Thakur N, Piggott CA, Omi S, Polanowska J, Jin Y, and Pujol N. Coordinated inhibition of C/EBP by Tribbles in multiple tissues is essential for Caenorhabditis elegans development. BMC Biol. 2016 Dec 7;14(1):104. DOI:10.1186/s12915-016-0320-z |
- McEwan DL, Feinbaum RL, Stroustrup N, Haas W, Conery AL, Anselmo A, Sadreyev R, and Ausubel FM. Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway. BMC Biol. 2016 Dec 7;14(1):105. DOI:10.1186/s12915-016-0334-6 |