Kinase Group CMGC

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Kinase Classification: CMGC

The CMGC group (named after the initials of some members) includes key kinases: the MAPK growth- and stress-response kinases, the cell cycle CDK (cyclin dependent kinases) and kinases involved in splicing and metabolic control.


Evolution

This is an ancient group, with several families found in most or all eukaryotes.

Families

There are 9 highly-conserved CMGC families:

CDK: Cyclin Dependent Kinases

CDKL: CDK-like Kinases

CK2: Cell Kinase 2 (Casein Kinase 2)

CLK

DYRK

GSK: Glycogen Synthase Kinase

Kinase_Family_MAPK: Mitogen-Activated Protein Kinase

RCK

SRPK: SR-rich protein kinase