Kinase Group TK
This group phosphorylates almost exclusively on tyrosine residues, as opposed to most other kinases that are selective for serine or threonine. The group appears to be the youngest of kinase groups, as it is absent from plants and unicellular organisms like Dictyostelium and yeast.
Families
This group is very well studied, and quite diverse, and so has the largest number of distinct families of any group.
Receptor Tyrosine Kinases (RTKs)
FGFR
Fibroblast Growth Factor Receptors.
VEGFR
Vascular Endothelial Growth Factor Receptors. Three of these, in vertebrates, control the develoment of the vascular system (blood) and lympatic system, and are important targets for anti-angiogenesis drugs for cancer. No clear VEGFR exists outside of vertebrates, but Drosophila has a pair of genes that appear to be intermediate between VEGFR and PDGFR families
PDGFR
Platelet-derived growth factor receptors. In vertebrates, these include a pair of PDGFRs, as well as the realted receptors fms (CSF1R), kit and flt3, growth factor receptors involved in blood cell development, testictular development and some other processes. As above, insects have receptors that are intermediate between PDGFR and VEGFR families.
EGFR
Epidermal Growth Facor Receptors. (also in invertebrates...)
Tie
This pair of vertebrate-only receptors is involved in angiogenesis.
Trk
Neurotrophin receptors; important growth factor receptors that act on neuronal cells.
Eph
Ephrin receptors guide maping of optical neurons to the brain, among other functions. Invertebrates have just a single member of the family, which explodes into 14 members in vertebrates.
Fak
DDR
Ror
Ret
Met
Lmr
Non-receptor tyrosine kinase families
Src
Jak
