Difference between revisions of "Kinase Subfamily CDK16"
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The kinase domain is in the middle with typically 100-150 AA of sequence N-terminal and about 40 AA C-terminal without known domains. | The kinase domain is in the middle with typically 100-150 AA of sequence N-terminal and about 40 AA C-terminal without known domains. | ||
====Function==== | ====Function==== | ||
− | + | CDK16 is activated by Cyclin Y to which it binds both in the kinase domain and N-terminal unique region. CDK16 members are not associated with cell cycle and are expressed in post-mitotic tissues like brain and testis | |
====References==== | ====References==== | ||
<biblio> | <biblio> | ||
</biblio> | </biblio> |
Latest revision as of 07:28, 12 November 2021
Kinase Classification: Group CMGC: Family CDK
CDK16 (PCTAIRE)
Evolution
CDK16 is found in most animals and choanoflagellates, but is lost in Drosophila. Three members (CDK16, 17, 18 or PCTAIRE1, 2, 3; PCTK1, PCTK2, PCTK3) are found in mammals. Within the CDK subfamilies it is most closely related to the animal-specific CDK14 (PFTAIRE) subfamily.
Domain Structure
The kinase domain is in the middle with typically 100-150 AA of sequence N-terminal and about 40 AA C-terminal without known domains.
Function
CDK16 is activated by Cyclin Y to which it binds both in the kinase domain and N-terminal unique region. CDK16 members are not associated with cell cycle and are expressed in post-mitotic tissues like brain and testis