Kinase Subfamily CDK7

Kinase Classification: Group CMGC: Family CDK: Subfamily CDK7

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Evolution

CDK7 is found in most eukaryotes, typically as a single-copy gene. A number of basal lineages, including ciliiates and Giardia sp. lack CDK7 and also lack the repeat region of RNA polymerase 2 which is a major CDK7 substrate.