Kinase Subfamily DYRKP

Potential plant homologues of human Dyrk1a (UniProt ID:Q13627) exhibits 31-60% sequence identity. At the same time, the similarity was 50-79% and 15% of gaps. All plant sequences are represented by proteins with unknown function (July 21-24, 2011), and have «Unreviewed» UniProt status. The Neighbor-Joining clustering of plant homologues and «Reviewed» DYRKs catalytic domains resulted in common clade. Based on common clustering the 34 plant homologues were identified, among them 18 potential plant DYRK-like kinases were represented by complete sequences (Fig).

KARPOV P.A., RAEVSKY A.V., ISAENKOV S.V., SPIVAC S.I., BLUME Ya.B. Identification of Plant Homologs of Dual Specificity Yak1-Related Kinase 1A. Proceedings of the International Moscow Conference on Computational Molecular Biology (MCCMB’11). 2011, Moscow, Rossia. – P.148-149. RAEVSKY A.V., ARPOV P.A., KORABLYOV M.D., ISAENKOV S.V., BLUME Ya.B. Prediction and Validation of Plant DYRK1A Homologs Spatial Structure. Proceedings of the International Moscow Conference on Computational Molecular Biology (MCCMB’11). 2011, Moscow, Rossia. – P.148-149.