Difference between revisions of "Kinase Subfamily IP3K"
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Latest revision as of 01:36, 23 April 2014
Kinase Classification: Group PKL: Subfamily IPK: Subfamily IP3K
IP3K is a non-protein kinase that phosphorylates inositol (1,4,5) tri-phosphate on the 3 position, to create Ins(1,3,4,5)P4.
Kinase Domain
The IPPK kinase domain is most similar to that of PIPK, which is itself a remote member of the PKL fold, and related to other inositol phosphate kinase families [1, 2]. SCOP classifies both IP3K (called IPK) and PIPK in the SAICAR synthase-like superfamamily with similarity to both the PKL and the ATP-Grasp folds. This was first predicted by deep sequence comparison [3] and confirmed by a crystal structures [1, 2, 4]. Like PIPK kinases, the N-lobe is closer to PKL while the C-lobe has similarities to the ATP-Grasp fold. The K72, D166 and D184 catalytic residues of PKLs are well conserved in IP3K [3].
Evolution
The family is found in most eukaryotes, and has three copies in human (ITPKA, ITPKB, ITPKC).
Naming
As with most inositol kinases, IP3K have several names, I3P3K, IP3-3K, ITPK (inositol-trisphosphate 3-kinase) and 1D-myo-inositol 1,4,5-trisphosphate 3-kinase. While human names are named with the root ITPK, this is also the name of a different family of lipid kinases.
References
- González B, Schell MJ, Letcher AJ, Veprintsev DB, Irvine RF, and Williams RL. Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase. Mol Cell. 2004 Sep 10;15(5):689-701. DOI:10.1016/j.molcel.2004.08.004 |
- Miller GJ and Hurley JH. Crystal structure of the catalytic core of inositol 1,4,5-trisphosphate 3-kinase. Mol Cell. 2004 Sep 10;15(5):703-11. DOI:10.1016/j.molcel.2004.08.005 |
- Cheek S, Ginalski K, Zhang H, and Grishin NV. A comprehensive update of the sequence and structure classification of kinases. BMC Struct Biol. 2005 Mar 16;5:6. DOI:10.1186/1472-6807-5-6 |
- Takazawa K, Perret J, Dumont JE, and Erneux C. Molecular cloning and expression of a human brain inositol 1,4,5-trisphosphate 3-kinase. Biochem Biophys Res Commun. 1991 Jan 31;174(2):529-35. DOI:10.1016/0006-291x(91)91449-m |
