Kinase Subfamily KACAD

Kinase Classification: Group PKL: Family CAK: Subfamily KACAD

This Article is a STUB.

KACAD is a CAK kinase fused to an ACAD (acyl-coA dehydrogenase) in many eukaryotes, and also found in some bacteria.

Evolution

KACAD is found in in most eukaryotes and some bacteria.

ACADs Two human acyl CoA dehydrogenases (ACADs) lack the typical ACAD N-terminal domain, replacing it with a PKL kinase domain that is most similar to a subset of uncharacterized bacterial CAK kinases. This ACAD-CAK hybrid is seen in most eukaryotes other than insects and some fungi. No substrate is known, and their functions are obscure. These were originally described based on remote homology searches for novel kinases ({Kannan, 2007 #232}{Briedis, 2008 #318}). All appear to be catalytically active (Fig. 1).