Difference between revisions of "Kinase Subfamily Kit"
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Latest revision as of 06:39, 9 February 2022
Kinase Classification: Group TK: Family PVR: Subfamily Kit
Kit is a vertebrate-specific subfamily of receptor tyrosine kinases, including the human genes kit, Flt3 and Fms/CSF1R, involved in blood cell development and various other functions.
Evolution
The three kit family members are found in all vertebrates, but not in any invertebrate. They likely arose as a tandem duplication of an ancestral PVR gene, which was then double-duplicated by the whole genome duplication at the base of the vertebrates. Duplicate kit and fms genes are found in fish.
Domain Structure
The extracellular region consists of 5 Immunoglobulin repeats, flanked by a signal peptide and a transmembrane region, while the intracellular region encodes a kinase domain and several other important short functional motifs.
