Kinase Subfamily MAK
MAK is found in all eukaryotes examined to date. Vertebrates have two copies: MAK and ICK, while most invertebrates have one copy.
All MAK kinases have an N-terminal kinase domain and a variable length (~100-300 AA) C-terminal tail without any known domains.
All MAK kinases have a TEY motif in their activation loop. The Y is autophosphorylated, while the T is phosphorylated by CDK20 (CCRK) . Protein phosphatase 5 (PP5) binds to and can dephosphorylate ICK on T157
C. elegans dyf-5 (M04C9.5) is well-characterized for it's role in regulating flagellar length, and the localization of several other proteins in the flagellum (cilium). Dyf-5 is expressed under the control of the flagellar transcription factor, DAF-19.
Yeast IME2 is involved in meiosis and pseudohyphal growth
Human ICK (Intestinal Cell Kinase)
Human MAK (Male germ-cell Associated Kinase) is expressed almost exclusively in germ cells of the testis. In rodents, it associates with the synaptonemal complex (paired chromosomes) during meiosis. Mouse MAK is also expressed in developing sensory epithelia, including photoreceptors, olfactory receptors and the respiratory tract . In the retina, MAK is found in the connecting cilia and outer-segment axonemes of photoreceptor cells and loss of MAK results in longer cilia 
Mde3 and Pit1 in Schizosaccharomyces pombe
dyf-5 encodes a putative MAP kinase orthologous to human MAK/ICK (OMIM:154235), Chlamydomonas reinhardtii LF4, and Leishmania mexicana MPK9; DYF-5 negatively regulates cilial length, restricts KAP-1 to middle ciliary segments, is required for normal localization of six IFT components, and is required for OSM-3 to comigrate normally with IFT particles; DYF-5 is also required for dye-filling of amphid and phasmid neurons and for normal chemotaxis, dauer formation, and male mating; DYF-5 is expressed in head neurons (including amphid neurons), tail neurons (including phasmid neurons), CAN cells, excretory canal neurons, posterior lateral ganglion neurons and in many male tail cells; dyf-5 mutant cilia are abnormally elongated, either failing to enter the amphid channel or accumulating IFT proteins at their distal ends, whereas DYF-5 overexpression results in truncated cilia; the dyf-5 promoter region contains an X-box, predicted to be bound and transcriptionally activated by DAF-19, and dyf-5 is regulated by DAF-19 in vivo; dyf-5 animals are slightly shorter than normal. [details]
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