Difference between revisions of "Kinase Subfamily MEK5"
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====Domain Structure==== | ====Domain Structure==== | ||
MEK5 kinases have an N-terminal PB1 domain that mediates dimerization with the upstream MEKK2 kinases, and a C-terminal kinase domain. | MEK5 kinases have an N-terminal PB1 domain that mediates dimerization with the upstream MEKK2 kinases, and a C-terminal kinase domain. | ||
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| + | ====Control of activity==== | ||
| + | As part of the ERK5 cascade, MEK5 is phosphorylated and activated by kinases [[Kinase_Subfamily_MEKK2|MEKK2]] subfamily kinases.. | ||
====Functions==== | ====Functions==== | ||
Revision as of 02:25, 6 December 2023
Kinase Classification: Group STE: Family STE7: Subfamily MEK5
MEK5 phosphorylates ERK5 as part of the ERK5-variant MAPK pathway
Evolution
MEK5 is found as a single copy, only in animals. It is secondarily lost from most insects and nematodes, along with its pathway members, MEK5 and MEKK2. Vertebrates have a single copy, known as MEK5, MAPKK5, or MAP2K5.
Domain Structure
MEK5 kinases have an N-terminal PB1 domain that mediates dimerization with the upstream MEKK2 kinases, and a C-terminal kinase domain.
Control of activity
As part of the ERK5 cascade, MEK5 is phosphorylated and activated by kinases MEKK2 subfamily kinases..
Functions
MEK5 is tightly linked to the activation of ERK5. See the ERK5 article for more information on functions of this cascade.
